Enhance Neuroplasticity, Reduce Alzheimer’s Risk through Exercise

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Summary
  • The best exercise for brain health at any age.
  • How women and men differ in AD risk.
  • Combining cognitive training with physical training.
Transcript
Heather Sandison, N.D.

Welcome back to the Reverse Alzheimer’s Summit. I’m your host, Dr. Heather Sanderson, and I’m thrilled to have Dr. Sarah McEwen here today. Dr. McEwen is a cognitive psychologist and has 15 years of research experience in both academic and clinical settings. Dr. McEwen has a PhD in psychology and completed her NIH T32 fellowship in cognitive neuroscience in the UCLA Department of Psychology. She has extensive experience in human functional brain imaging in the fields of severe mental illness, neurodegenerative and neurocognitive disorders using innovative multimodal MRI approaches to identify brain changes in structural and functional connectivity and neurochemical markers of exercise dependent neuroplasticity. Dr. McEwen is a senior research scientist at the Providence St. John’s Health Center, Pacific Brain Health Center in Santa Monica, California, where she conducts precision medicine, randomized controlled trial research in patients with mild cognitive impairment and early Alzheimer’s disease. Dr. McEwen also serves as an editor for the peer reviewed journal “NeuroReport.” She is also an associate professor in the department of translational neurosciences, and neurotherapeutics at the St John’s Cancer Institute, and was previously a research scientist in the School of Medicine, Departments of Psychiatry at UCSD and at UCLA. 

While faculty at UCLA, she was the PI of an NIMH K1 and an NAR SAAD, Young Investigator Awards, and a prior primary investigator of a CTSI pilot study of a memory and exercise training program in older adults. She is currently a co-investigator on an NIMH R1 of exercise and cognitive training in psychosis patients and national Parkinson’s Foundation Award, looking at the differential effects of motor and aerobic fitness on brain circuitry in Parkinson’s patients, with mild cognitive impairment. Dr. McEwen is also currently the primary investigator of NIA R21, she’s conducting the Pacific Brain Health Center to study the effects of a digitally delivered home-based exercise and compensatory memory training program in patients with mild cognitive impairment. This is an important trial to conduct in this emerging field of combinational early cognitive remediation interventions in mild cognitive impairment, should prevent the progression to Alzheimer’s disease. She’s also passionate about advancing clinical care and treatment in an outpatient setting while also developing, studying, and implementing Novel Multimodal Lifestyle Intervention Programs. Dr. McEwen, welcome to the summit. That is impressive, by all.

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