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Kent Holtorf, MD is the medical director of the Holtorf Medical Group (www.HoltorfMed.com) and the founder and medical director of the non-profit National Academy of Hypothyroidism (NAH) (www.NAHypothyroidism.org), which is dedicated to the dissemination of new information to doctors and patients on the diagnosis and treatment of hypothyroidism. He is... Read More
I am a board certified OB/GYN specializing in the fast-changing field of anti-aging medicine for men and women, and gynecological services based on nutritional and hormonal approaches. I believe in holistic, complete, and personalized care. Women of all ages can greatly benefit from natural methods of birth control, infertility treatments,... Read More
Many women have gone through incredible lengths to try and conceive. Failing to conceive through IVF treatments and other interventions can take a financial and emotional toll on couples. Join Dr. Uzzi Reiss, an internationally recognized obstetrician and gynecologist in discussing how peptides have increased fertility for many of his patients. He specializes in advancing medicine from a holistic and personalized approach and has written several books to help women empower themselves to take back their health! Read more about the symptoms in the DrTalks’s PCOS Guide.
Kent Holtorf, M.D.
Hi, it’s Dr. Kent Holtorf with another episode of the peptide summit. Today my special guest is Uzzi Reiss. He’s going to talk about infertility and how peptides can optimize your chance of getting pregnant, even after multiple fertility treatments. And it’s not just peptides as well, it’s numerous interventions, and we’ve seen the same thing that people try multiple IVFs, don’t get pregnant, come in, optimize a number of things, and they get pregnant naturally. And these fertility doctors are just missing it all. Then also we’re going to try to fit in finally breaking free from PCOS with peptides. So, Dr. Reiss has been been around—God, I’ve known him for I don’t know how long, seen him at all the conferences. He’s an esteemed, internationally recognized obstetrician and gynecologist. He’s an author and speaker after serving in the Israeli army as a paratrooper officer. He’s bad ass! Dr. Reiss began his studies in Italy and Israel, later completed his post doc work at New York’s Albert Einstein College of Medicine.
Over his career Dr. Riess remained at the forefront of medical innovation co-authoring research related to the role of prostoglandins and the cessation of premature labor. He has been in private practice for over 30 years. He’s basically the OB to the stars. He’s become a champion of the safety of [inaudible] hormones to treat PMS, menopause, other hormonal symptoms, the benefits of nutritional regenerative medicine. Indeed he has spoken widely to academic audiences—I’ve heard him speak a number of times, and he’s a great speaker—around the world, testing to how his approach to better the wellbeing and lives of thousands of women that he has treated. He’s the author of four highly acclaimed books, with the fifth, The Truth About Estrogen forthcoming in 2019. We’ll hear about that, which is a controversial topic, but he just packs in the literature and supports his stance with study, after study, after study. He shared his message of holistic wellness, empowering women to embrace their health and prevent disease. He’s married since 1982—maybe that’s your biggest accomplishment? No, kidding. But Dr. Reiss is the father of three grown children and grandparent to five and he lives in the Los Angeles area. Well, welcome. Uzzi, it’s so good to have you. Yeah, thanks for being on.
Uzzi Reiss, M.D.
It’s the end of a long day.
Kent Holtorf, M.D.
Yeah, let’s talk about infertility.
Uzzi Reiss, M.D.
Okay. Infertility is today a big issue because we conceive too late and the solution is very simple. You can’t get pregnant, we’ll do IVFs, and you’ll get pregnant. But this process is so complicated. It’s so expensive. It’s not successful all the time. The success is relatively low. Why? We forget simple things. Like, if you take infertility, it’s basically related to imbalance between antioxidants and free radicals in the blood. This imbalance causes problem with implantation, causes problems with fragmentation of the egg, causes pathology in the embryo, difficult for implantation. Every aspect of fertility gets affected by that.
Kent Holtorf, M.D.
Now is it that women are told, “Oh, you only have so many eggs and that’s it”?
Uzzi Reiss, M.D.
Well, we know it’s so much not true today.
Kent Holtorf, M.D.
Yeah.
Uzzi Reiss, M.D.
You’re doing more work with me about PRP and STEM cells. They take today, women in menopause, full blown menopause, not [inaudible] menopause and injecting STEM cells or PRP into their ovaries. And many times, and more now that the science is growing, they develop eggs that can be extracted, and later on manipulate it and put in the uterus. This 55 year old woman, who never wanted to get pregnant, and after she goes into menopause, tried to do anything she can. Here she’s is pregnant with the embryo that the egg was extracted after the woman was in menopause.
Kent Holtorf, M.D.
Well, no one believed them.
Uzzi Reiss, M.D.
And there are more and more places that are doing it now.
Kent Holtorf, M.D.
Well, it’s interesting—I’m jumping a little ahead, but like the study on Epitalon, this is a rat study, but they took menopausal rats. They gave them the Epitalon peptide, pineal peptide, so many anti-aging aspects of that and we’ll get into it, and about 80% of the rats started menstruating again and 25% had normal litters.
Uzzi Reiss, M.D.
I think what the Epitalon does is it affects the kisspeptin in the body. The kisspeptin is basically the major peptide that affects our endocrine system. When it’s not working, we have a lack of maturation of our sexuality, women don’t ovulate. I think that Epitalon helps it. Also, Epitalon corrects the circadian rhythm. We forget that we’re born to live in a rhythm, and the reason was very simple. In first hundred thousand years, all of them were in warm countries. We would wake up in the morning. We would be in the sun all day long, that builds a lot of melatonin. The minute the sun is down, we’d be in darkness until the next day. We haven’t lived like this for one single day.
Kent Holtorf, M.D.
No.
Uzzi Reiss, M.D.
One single day. We didn’t follow the circadian rhythm. But when you start to follow the circadian rhythm, suddenly things improved, significantly. So in the same way, if you can, you want to wake up in the morning to the sun and be in the sun. In the evening you want to keep everything low and dim and not light. Now, I first start with infertility with a lot of antioxidants. I measure them, but through the years—I do it for more than 30 years. Each time I added more things, peptides I haven’t used until five years ago. But we would take women, they were told they cannot conceive, and they have conceived because any specific antioxidant, quercetin,
Kent Holtorf, M.D.
Yeah.
Uzzi Reiss, M.D.
So antioxidant is so simple, it makes so much sense to do, to use. There’s never data that it creates problems.
Kent Holtorf, M.D.
Yeah, I feel like it kind of all fits together with—it’s like, everyone’s sick, you know? From whatever, toxin, pesticides, plastic, stress, not sleeping, but that immune modulation, mitochondrial dysfunction, it’s all causing all this reactive oxygen species and they’re just overloaded and they need tons of antioxidants. You look at—it’s nice, if you use some of the peptides and modulate the immune system, your body makes its own antioxidants.
Uzzi Reiss, M.D.
Indeed, indeed. When you deal with peptides you know that they constantly give antioxidants. How many people you see say, “All my life I take vitamin C. I take vitamin E.” Basically it doesn’t benefit them.
Kent Holtorf, M.D.
Yeah.
Uzzi Reiss, M.D.
When the body creates it through the peptide, then you benefit from it.
Kent Holtorf, M.D.
It’s all that.
Uzzi Reiss, M.D.
One arm is antioxidant. It’s a simple arm. The second arm is hormone. The data on human growth hormone and enhanced fertility is significant. This is a very important issue that I want to emphasize. There is tremendous amount of literature about human growth hormone improving every aspect of fertility. Not only there, in the very beginning of IVF, whenever IVF had increased the human growth hormone level and a woman received it, the success was significantly higher. So now, at a time that we know it, and we know about peptide, people started to give HGH peptide to infertility. Here we have to be very careful because when we do infertility, we want something that’s 100% hundred percent [inaudible]. We all like the HGH peptide, it was created out of the HGH molecule, because it’s more convenient and has less side effects, many times decreases significantly cancer in the body. But it can cause horrified anomalies.
Kent Holtorf, M.D.
What was that you said?
Uzzi Reiss, M.D.
It can cause a lot of anomalies, okay? And they even—HGH peptide that causes [inaudible] which is an anencephaly. So you have to remember, you have to use the classical HGH, not HGH peptide. Anything you use has to be bio-identical. It’s very important because people forget about it.
Kent Holtorf, M.D.
Because, yeah, even the fertility doctors have been using that.
Uzzi Reiss, M.D.
They use HGH now.
Kent Holtorf, M.D.
Yeah. I was just thinking, growth hormone is the one thing that can’t be given off label.
Uzzi Reiss, M.D.
Yeah. But they give it and they make the [inaudible], it’s ridiculous. It has to be started about six weeks to three months [inaudible], also with nutrients. They say you need at least three months of this nutrient to have effect. It’s not something that happens overnight.
Kent Holtorf, M.D.
Yeah. Because it changes protein synthesis, it’s got to do all its thing.
Uzzi Reiss, M.D.
Exactly.
Kent Holtorf, M.D.
Yeah.
Uzzi Reiss, M.D.
So this is really to make sure that you don’t use the HGH peptide.
Kent Holtorf, M.D.
Now, do you like using the growth hormone releasing peptides, growth hormone releasing hormones?
Uzzi Reiss, M.D.
Yeah, those ones can cause anomalies. Tesamorelin and anencephaly, a lot of anencepgaly. A lot of pup, like in mice, are born without a head. And it’s super strong, HGH peptide. [Inaudible]
Kent Holtorf, M.D.
Because it’s stimulating your own body’s production—
Uzzi Reiss, M.D.
It’s different. It’s not bio-identical so you don’t have to [inaudible]. I’ve used [inaudible] for about 35 years, I don’t remember ever an issue in terms of side effects. Another hormone that we forget about it all the time is melatonin. And again, when we talk about melatonin, we talk about the circadian rhythm. This is the most abused hormone in the body because we don’t have enough and I see the study, check your melatonin. Check you have more than enough melatonin. How we can have enough melatonin? We are not in the sun all day long. And the evening comes, we are in the light again, what is it? It doesn’t exist. Melatonin helps so many levels of fertility, melatonin can induce fertility.
Kent Holtorf, M.D.
Do you think it’s a combination of the sleep and the antioxidant that’s such a good intracellular antioxidant? And do you like Epitalon to raise that?
Uzzi Reiss, M.D.
It’s a big manipulator of estrogen. You know, you take melatonin—melatonin is [inaudible], it’s [inaudible]. All—every process that Estradiol is built, is either built from testosterone, or it’s built from estrone sulfate. All of them are manipulated by melatonin.
Kent Holtorf, M.D.
Interesting. What doses do you like to give?
Uzzi Reiss, M.D.
Okay. We know that 40 milligram, at one time, 40 milligram, causes infertility, especially in male. Okay? So best to dose—you always have to remember about these two doses. First the tolerable dose. Most people will not tolerate over 7, 8, 9 milligram. Like at 6 milligram I tolerate, at 7 within 5 minutes I’m in constant horror story. I immediately see myself in a grave trying to get out of the grave.
Kent Holtorf, M.D.
Really?
Uzzi Reiss, M.D.
And I use 40! Because when you go way beyond 8, you bypass the receptor.
Kent Holtorf, M.D.
Yeah.
Uzzi Reiss, M.D.
So if you into high dose of melatonin, that has a lot to do—we give it a lot to cancer patients. Kent Holtorf
Kent Holtorf, M.D.
Yeah, yeah.
Uzzi Reiss, M.D
Autoimmune disease, inflamed patients, 20, 40 milligrams will never give you side effects. Now we have to remember, we want to take it when it’s dark. When you take melatonin for sleep, melatonin helps you fall asleep, not stay asleep. So it can be repeated. DHA, it’s an incredible product, the data on DHA are significant. So many that fail IVF, came back to life with DHA. I think they used too high of a dose. They use a dose they give to people [inaudible] all over. For me, it’s overdosing it and shouldn’t be used.
Kent Holtorf, M.D.
What dose are the fertility docs doing? I know they give testosterone.
Uzzi Reiss, M.D
They give—okay, I’ll tell you something about testosterone. They give 75 milligram and it doesn’t make sense. It agitates, makes them irritable. You don’t want that. You want physiological dose that don’t get side effects.
Kent Holtorf, M.D.
Yeah, ’cause women will convert it to DHT, which is more potent.
Uzzi Reiss, M.D
People forget the DHEA decreases the secretory phase. It can block the production of progesterone so you can never give it alone. You always had to add progesterone when you give DHEA. So many times people say, “I added DHEA, nothing happened.” You always have to support it with progesterone.
Kent Holtorf, M.D.
Even at low doses?
Uzzi Reiss, M.D
You create. It affects the transfer of follicle to be ovulated. So always remember when you use DHA, also support—
Kent Holtorf, M.D.
I thought you were saying it’s very good to give for infertility?
Uzzi Reiss, M.D
It’s good, but it cannot be given alone. You have to support the progesterone in the body. Because it’s [inaudible], that’s the right term. It’s [inaudible] by itself.
Kent Holtorf, M.D.
Now—
Uzzi Reiss, M.D
If supported with progesterone, it’ll give you the benefit and will not have a drawback.
Kent Holtorf, M.D.
So that’s what’s happening with the PCOS patients? They get high DHEA, too high and they don’t—
Uzzi Reiss, M.D
You know, there are theories today, okay, about the PCOS. It’s interesting. They all thought that high DHEA typical to PCOS patient, it’s protective. It’s done as a cardiovascular protective tool. Also today there are people that claim that that’s the main reason for polycystic ovary and indeed to induce PCOS in mice, you give them high dose DHEA. So that hasn’t been solved yet, whether DHEA help or not help, but obviously there’s tremendous amount of data that if you take women that fail again, and again, and again, you put them on DHEA, many times they can escape the failure and this cycle can be saved.
Kent Holtorf, M.D.
Now, do you think part of it is—it’s great for one of the treatments for autoimmune disease?
Uzzi Reiss, M.D
Okay. DHEA does everything. It’s anti-autoimmune. So look, what we’re looking, anti-autoimmune, anti-inflammatory, anti-viral, anti-diabetic, and it’s an adaptogen. It’s an incredible adaptogen. Like when you take DHEA before you go to high elevation, you don’t feel the high elevation. So you take an incredible hormone that’s an adaptogen, you give it to women at a time of extreme stress, it’s anti-stressful. So I think it adds a lot of things to the whole ball game. Now, testosterone is also important but its use has to be very limited. Testosterone, especially in the very beginning of the follicular phase, the 4, 5, 6, 7, start to be in the selection of the dominant follicle and then IGF-1 takes over.
So this is one of the peptides that I’m using, IGF-1. I usually use it from day 7 to day 14, because that will select the dominant follicle. And again, we should use the pure IGF-1 and not the peptide IGF binding protein, because it’s not bio-identical. So, and I always—if I can, I add kisspeptin. Because kisspeptin is this miracle that can keep the endocrinologist or the fertility guy away. Because with kisspeptin—yeah. You keep him away because with kisspeptin you both develop the follicle and you release it and never with hyperstimulation. If we talk about PCOS there’s a pretty—I think it’s a 15 to 20%. Yeah, if you look for pure, pure, pure, it’s lower.
Kent Holtorf, M.D.
Right, right.
Uzzi Reiss, M.D
One of the only very dangerous issue with inducing fertility, hyperstimulation. Many of the women that have polycystic ovary, then they start to give them growing doses of estrogen, the body overreacts. And this is sometimes a life threatening situation. They have edema many times, they have kidney failure, they have liver failure. And it’s interesting, the closer they are to this critical situation, the more likely that they’ll conceive. But when we use kisspeptin, we don’t need it. The likelihood of those complications is so minimum.
Kent Holtorf, M.D.
How do you dose that?
Uzzi Reiss, M.D
I use 0.1 ML. There’s not too many studies, and I give it until a week after ovulation, because there’s a data that if you add it also a week after ovulation, you further increase the success of fertility. Now—
Kent Holtorf, M.D.
And just for everyone, so kisspeptin stimulates FSH, LH?
Uzzi Reiss, M.D
Yeah. Indeed. And it does it very good. We use it in men today. They took our hCG away, we have kisspeptin now.
Kent Holtorf, M.D.
I know, it’s getting crazy.
Uzzi Reiss, M.D
Now, as I was saying, what about the sort? And that’s—I’m going to introduce later. Mitochondrial peptide and infertility. If you take SS-31, it’s a major inner mitochondrial peptide. Basically every process in the body that gooes south, can reverse to a certain degree by SS-31. Prevent glaucoma, improve brain function, prevent otosclerosis, eliminate the form cell, eliminate arthritis, build muscle, break fat, decrease insulin resistancy, improve kidney function, prevent fibrosis of the kidneys, significantly decrease hypertension. So it kind of reverse pathological situations that we gain as we age. I think the next time that I have a fertility person, I will give them SS-31.
Kent Holtorf, M.D.
Yeah, it’s hard to get. It’s in clinical trials—
Uzzi Reiss, M.D
No, we get it though.
Kent Holtorf, M.D.
Yeah, and—
Uzzi Reiss, M.D
But again, it’s relatively expensive but overall then you don’t need to use a fertility drug. The whole process is not as expensive.
Kent Holtorf, M.D.
Because—and those fertility drugs are nasty. People feel terrible on them. There are huge swings and everything. And we’re finding the mitochondrial boosters are, I mean, the key to so many things.
Uzzi Reiss, M.D
Sure.
Kent Holtorf, M.D.
Like, we’ll use the 5-amino 1MQ which we have people with bipolar, OCD, chronic fatigue syndrome, Lyme, with all the diseases of aging neurodegenerative diseases. I mean, they all have chronic infections, the mitochondria shut down.
Uzzi Reiss, M.D
When you take it, in the morning you get up and suddenly you feel youthful. Much more youthful.
Kent Holtorf, M.D.
Yeah. Yeah. And then mitichondria shuts down, you have all this—it increases all the reactive oxygen species. Everything’s a vicious cycle. You get immune dysfunction. In fact, I’m giving a talk on thyroid. The biggest cause of low thyroid is mitochondrial dysfunction and immune dysfunction. Not Hashimoto’s, you know?
Uzzi Reiss, M.D
Now, if you look at this, we’re using a lot of [inaudible]. [Inaudible] is one of the tools which we use to eliminate senescence. So we talk about infertility and fertility creates new life, senescence is was is going to send us to hell or to heaven. And one of the things that is very successful is [inaudible].
Kent Holtorf, M.D.
So can you explain what senescence is?
Uzzi Reiss, M.D
Senescence is basically the deep aging of the body. That’s senescence, those are cells that don’t move anymore. They don’t do anything, just sit there and create problems and create inflammation, create cancer. So in Easter Island, they realised that everything that grows inside the ground of Easter Island
lives much longer. So you have a cockroach, you live 50% longer in the ground of Easter Island than anywhere else. Why? It’s suppressed the senescence process. So there’s a common term in infertility called RIF, recurrent implantation failure. And that’s driving them crazy because they have all those embryo and by all their calculations they’re healthy, they are good. We know they don’t have chromosomal anomaly, they are in perfect size. You implant them and they don’t take. You give [inaudible], they take. Because [inaudible] enters into the ratio of TH17 and theoretic. And—yeah. Also, suppresses deep endometriosis.
Kent Holtorf, M.D.
Yeah. So it’s similar, it sounds, to the Thymosins, right?
Uzzi Reiss, M.D
Especially if you have anything autoimmune. Look, I believe that most of the women today that come to infertility, they have certain degree of endometriosis because we were supposed to get pregnant, breastfeed, get pregnant, breastfeed, get pregnant, breastfeed, get pregnant. The first 5 year of medicine that I did younger residents in Israel, and in the place that most women, that’s what they did. They got pregnant at 16, 17, 18, 19, and then they got pregnant and breastfeed until their mid 40s. You never see infertility, you never see endometriosis. You never see breast cancer. You never see endometrial cancer. None of the disease that we see, but every month that women menstruate, they forget that there’s also retrograde menstruation, this blood that comes through the tube into the pelvic. And what is the blood that comes from the uterus? It’s live endometrial cells that get implanted. So there’s nearly always, if you take women over 30, they always have certain degree of endometriosis. That’s why, again, that’s why low dose naltrexone. That’s why then people put BPC.
Kent Holtorf, M.D.
So again, immune modulators—’cause yeah, it’s through to be auto-immune, correct? At least there’s evidence to that.
Uzzi Reiss, M.D
A lot of it is autoimmune. That’s why TB4 decreases the formation of scar tissue, the scar tissue is endometrial. This has a lot to do with it. That Thymosin α1 will be positive. It’s interesting, when it comes to infertility and you explain what they do, the women will take it. When we come to do restorative medicine and you want to suppress senescence and it’s a few basic things, they need it, they are reluctant. But with infertility, they are never reluctant.
Kent Holtorf, M.D.
Oh, ’cause they want it bad. It sounds like a lot of these treatments again are balancing this—we’re all—everyone’s sick with autoimmune, where that TH1 is too low, TH2 is too high.
Uzzi Reiss, M.D
Exactly.
Kent Holtorf, M.D.
It’s funny, it’s just everyone. So those treatments—and peptides I think are nice because they basically bring things back to normal, you know? Like the Thymosin α1 and Thymosin beta-4, TB4-FRAG, brings it up like this. BPC brings the TH2 down and brings it back to balance.
Uzzi Reiss, M.D
One of the most important peptide is CJC [inaudible], but if I do CJC [inaudible]
Kent Holtorf, M.D.
Just for the viewers, yeah, the CJC is a growth hormone releasing hormone with the growth hormone releasing peptide, so it will stimulate your own growth hormone production.
Uzzi Reiss, M.D
And it’s a really—it produces more glutathione. It’s not as impressive. I use so much growth hormone. Copyright Ⓒ 2020 by Dr. Kent Holtorf
Kent Holtorf, M.D.
You know what, I have to agree that a lot of patients do well with it, but I think we’re finding—especially the sick patients that have this immune dysfunction, that they do much better with straight growth hormone.
Uzzi Reiss, M.D
But for longterm outcome, it’s probably not as good. [Laughing]
Kent Holtorf, M.D.
I don’t know. People worry about cancer, there’s no study that’s ever shown growth hormone gives a cancer, you know?
Uzzi Reiss, M.D
No, but growth hormone peptide it showed that it decreased cancer.
Kent Holtorf, M.D.
Yeah.
Uzzi Reiss, M.D
100% it decreased cancer. The simple way to look at the safety of growth hormone. If I would be born 20 years later, I wouldn’t be 5’3″ today. I will be 5’9″, 6 feet. Why? They will give me at the age of five human growth hormone. So look, they take 5 year old kids and give them 10 to 30 folds the adult dose, not 1/10th of the adult dose.
Kent Holtorf, M.D.
Yeah, it’s the opposite.
Uzzi Reiss, M.D
10 to 30 fold the adult dose. And they give it until the age of 18, for 15 years, constantly. Those kids were monitored better than any other group. They monitor for life. They never show any increase in cancer right now.
Kent Holtorf, M.D.
Yeah, yeah.
Uzzi Reiss, M.D
25% of this group are children, but stopped to grow because of the use of chemotherapy. Those too get, at age of 5, this huge dose of growth hormone and they never show higher frequency of recurrence of cancer.
Kent Holtorf, M.D.
Yeah. Yeah. They have a brain tumor that they’re on it for that, less recurrence, and it’s interesting. So I’m doing a power point, which kind of goes with what you’re saying, how it’s kind of universal is that with Hashimoto’s and low thyroid that they have basically antibodies against the pituitary, low mitochondrial function, and they also— someone with Hashimoto’s, they don’t make growth hormone very well.
Uzzi Reiss, M.D
No, very low. They don’t make much growth hormone.
Kent Holtorf, M.D.
Endocrinologist have no clue on that, you know? And the [inaudible] is so wide, it’s nuts.
Uzzi Reiss, M.D
Also it’s the lectin that’s an inflammatory factor, but you can go and eliminate all the lectins out of your diet. It will not work unless you add Thymosin α1 or LVN.
Kent Holtorf, M.D.
It sounds like you use a lot of immune modulatory. You love the Delta sleep and then STEM cells, PRP. Why don’t we talk about the gut? Do you think the gut plays a part?
Uzzi Reiss, M.D
This is the ABC. There’s a data, this beautiful data, they took women that had thin lining and somehow, with whatever they did, gave tons of estrogen. They couldn’t thicken the gut unless they gave them a large dose of prebiotic and probiotic. But the gut is everything. If somebody comes to me and they want infertility, they have to do full gut evaluation. I haven’t seen a person over 25 in the last 30 years that had perfect gut. We don’t have perfect guts. They always have something not right there. And it’s not so complex to correct the gut. But so many people have fat malabsorption. You know, the body don’t absorb fat. We cannot get good immunity without absorption of fat. A lot of it.
So many people don’t have enough acid to break the protein. So many don’t have enough enzyme to enhance the digestion or sterilize the food. So many of us don’t have short chain fatty acids, and the short chain fatty acid feeds the brain of the gut. Feed the inner layer of the gut, that’s everything. Today, we see more and more pathology in the inner layer of the gut. You all will come and say, “We think that this person is obstructed.” It means it has obstruction in his bowel because nothing gets moved, he’s swollen, but they do study. They see no obstruction. They see no big vessel that comes to the gut occluded. But what they found, that more and more, what is occluded is a small vessel that comes from the most important layer of the gut. Those people are losing their gut. You operate on them and you see necrotic gut. By the way, if they would be given enough BCP, it would be safe.
Kent Holtorf, M.D.
Yeah.
Uzzi Reiss, M.D
Tremendously.
Kent Holtorf, M.D.
Yeah. And it’s that gut brain access. The problem—the gut affects the brain, but also the brain affects the gut and even like low thyroid. Yeah. The majority have SIBO in one study, you know? And there’s just—yeah, so it’s a vicious cycle. That’s why I like BPC and TB4-FRAG, is that you give those, it’s working on the brain and the gut. So it gets all that, heals the gut, heals the brain, and you get that stuff working. It’s that immune system, you know?
Uzzi Reiss, M.D
I know. It’s a very good balance. So it basically—I’m telling any general physician or any general person on [inaudible], if somebody has infertility, it’s like a disease. It’s like you have hypertension, it’s like you have a headache. You have to learn about the whole body, all the antioxidant, all the free radical. We have to learn about heavy metals. We have to learn how you digest your food, how your bowel works. And step by step, you can correct it and suddenly the infertility gets corrected.
Kent Holtorf, M.D.
Yeah. It’s like so many things that I think we’ve really become—with my history with Lyme and three and a half years of highest dose of IV antibiotics didn’t work, I learned it’s the immune system. We’ve become immune modulatory clinic, and lo and behold, everything gets better.
Uzzi Reiss, M.D
Without antibiotics.
Kent Holtorf, M.D.
Yeah.
Uzzi Reiss, M.D
Many times.
Kent Holtorf, M.D.
And I guess the thing with fertility, autoimmunity, I mean, depression–
Uzzi Reiss, M.D
an example, one example. One time I got a woman that came to me, she was from very—ex royalty family from Pakistan. She went to really the best clinic in the country. Avid, religious, Muslim. At the age of 39, the professor of this very well known and respected, looked at her and said, “You’ll never, ever get pregnant.”
Kent Holtorf, M.D.
Yeah.
Uzzi Reiss, M.D
She comes to me and I said, “You know, you’re perimenopausal. I’ve seen women like you getting pregnant. I cannot promise you, but there’s a lot of things that you’re going to do.” My pleasure was that everything I would tell her, she’ll do it to the line. As I started, I get a call from the family doctor in London. “Why are you seeing her? Why give her false hope? Because she was told by the most known fertility person she’ll never conceive.”
Kent Holtorf, M.D.
Yeah, yeah.
Uzzi Reiss, M.D
To make this story short, I was sitting in the most beautiful restaurant in Tel Aviv on a beach. I get a call from this doctor, she’s horrified. She says, “The pregnancy test is positive!” And a professor in New York say, “It’s paradoxical.” I said, “Okay, what do you want from me? Paradoxical pregnancy? Leave me alone!”
Kent Holtorf, M.D.
I haven’t heard of a paradoxical pregnancy.
Uzzi Reiss, M.D
Yeah, I haven’t heard either. Don’t you think you should have the curiosity of what I did?
Kent Holtorf, M.D.
No, they don’t!
Uzzi Reiss, M.D
They don’t want to change their paradigm. They don’t want to hear.
Kent Holtorf, M.D.
That’s what I can’t comprehend. I’ve said it on a number of things, but you send a patient back that a doctor—or the patient loves the doctor. They come to us, we get them better after 10 years of, whatever it is, and you think the doctor would go, “Oh, what’d you do?” No. It’s like, “It’s quackery.” If a doctor doesn’t know what it is, it’s quackery. “But I’m better!” “Oh, no. It’s just placebo.” You know? Or it’s a miracle, you know?
Uzzi Reiss, M.D
If they asked me what you did, I send them to pray—especially in cancer patient, I send them to pray. They pray, they pray, everything is good. The [inaudible] woman came back to me two years later. Now she’s in complete menopause and she wants to do it again. I said, “I can’t do it. The egg looks dead. It’s before the time that they would inject STEM cell or PRP to the egg.” She said, “Okay—” She begged me and I said, “Okay, we’ll do it again.” And that time, I started to help her and she got pregnant.
Kent Holtorf, M.D.
Really?
Uzzi Reiss, M.D
So you see, I don’t do it frequently. I will not because people may be disappointed. I don’t want to look like a quackery. Here, she told me, she signed to me that she knows that there’s no way she could get pregnant. She got pregnant. So you take somebody in complete menopause. So it’s not irreversible, it’s reversible. If you give the body the right nutrients, with the right balance, with proper immunity. And here was one thing, there’s a woman that knows, but it works for her, but people say it does not. [Inaudible]
Kent Holtorf, M.D.
You’re gonna make a lot of women’s day when this airs. When they—’cause they’ve been told, “Just forget it, lady. You can’t get pregnant.” So, that’s awesome. The life changing things that you’ve done for women. And we see it too with fertility, they’ve gone through so many in vitros and spent so much money, you know?
Uzzi Reiss, M.D
All this process of in vitro, it’s very emotional. Finally, they have an egg. Now the egg goes and every day they know what happened to the egg. How it grows, what number. When we were young and women had spontaneous abortion—women were younger, it wasn’t natural. “Okay, but next time I’ll get pregnant.” But here is mourning each time that this egg doesn’t progress, it’s a mourning process. They make it more difficult to handle it in the future.
Kent Holtorf, M.D.
It’s like a conveyor belt too. So it’s like, “Oh, I’m sorry. You can’t get pregnant.” You know? But I was curious, do you see the AMH go up—alpha-Melanocyte-stimulating hormone go up in these patients?
Uzzi Reiss, M.D
It goes up in the patient that you inject STEM cell and PRP to the ovary. It definitely goes up.
Kent Holtorf, M.D.
Yeah, we’ve seen—
Uzzi Reiss, M.D
I can tell you, it is a marker,
Kent Holtorf, M.D.
It’s a piece of the puzzle.
Uzzi Reiss, M.D
Yeah. If you have good AMH, you probably have better chance. One other thing that I want to mention when it comes to fertility. I think a much higher percentage of the population have PCOS. The classical PCOS, we don’t see anymore. There used to be a condition called Stein-Leventhal syndrome. That was the classical more genetic type of PCOS. Today it’s a combo.
Kent Holtorf, M.D.
Yeah.
Uzzi Reiss, M.D
But there are always a few things that people forget. They always thought when you had PCOS, you make too much estrogen. No. The granulosa don’t make enough estrogen, most of them are estradiol deficient. Significantly estradiol deficient, significantly.
Kent Holtorf, M.D.
But they’re even more of progesterone, yeah.
Uzzi Reiss, M.D
But you see like you take just vitamin D and correct it and the granulosa start to produce more vitamin D.
Kent Holtorf, M.D.
Yeah, and I even tell people your—
Uzzi Reiss, M.D
Take vitamin D and the granulosas work better.
Kent Holtorf, M.D.
Yeah. I tell them, “Your PCOS-like, or PCOS-variant.” I put that on the chart. Yeah, I don’t even know what to put. But yeah, they don’t meet the criteria, but they sure as heck got a lot of the kinda stigmata of it. And just super quick, ’cause I know you have to go, but kinda with PCOS sounds like resistance to all the antioxidants, immune—
Uzzi Reiss, M.D
All medicines, the insulin resistancy. [Inaudible] Unfortunately we don’t have Liraglutide
Kent Holtorf, M.D.
It’s amazing, so it’s epigenetic and changes their kids. Some things you’re exposed to will change your kids’ kids!
Uzzi Reiss, M.D
Exactly.
Kent Holtorf, M.D.
Yeah. And what was—I didn’t hear what you said you couldn’t get anymore.
Uzzi Reiss, M.D
What?
Kent Holtorf, M.D.
You said we used to—
Uzzi Reiss, M.D
Ah, Liraglutide. We cannot get Liraglutide. You cannot get. That was one of the nicest peptides. We used a lot of it because, yeah, there’s a lot of pharmaceutical Liraglutide, okay? The problem, even if the person has a lot of money, they will not approve it—you’re not sick enough! Your hemoglobin A1C has to be 8 in order to get Liraglutide.
Kent Holtorf, M.D.
Oh, it’s crazy. I’ve had people like, “I’m going to gain weight and get worse so I can get my medications approved.” It’s crazy. So you basically—you like the insulin and basic—it sounds like immune modulators, TB4, BPC, also AOD as well. STEM cells. Get your sleep!
Uzzi Reiss, M.D
Good mental attitude, eat well, sleep, be happy, be quiet, be relaxed, sleep. You understand? In PCOS, by the way, there’s so many sleep apnea, such high degree of sleep apnea in PCOS.
Kent Holtorf, M.D.
Yeah. Poor sleep will kill you.
Uzzi Reiss, M.D
Yeah.
Kent Holtorf, M.D.
Yeah. Now kisspeptin, you use it for that? ‘Cause I think I read a study where kisspeptin was high in PCOS. But is the body trying to—
Uzzi Reiss, M.D
You want to induce labor, even many endocrinologists, they induce labor only with kisspeptin because it doesn’t cause hyperstimulation syndrome. You see the fact it’s high, it doesn’t mean that you have too much. It’s high to try to change the condition that’s not working.
Kent Holtorf, M.D.
Ding, ding, ding, ding. That’s one thing that doctors don’t get. They’re just looking at labs and go, “You’re high. Let’s bring it down.” Like, why are you high? You know?
Uzzi Reiss, M.D
Exactly.
Kent Holtorf, M.D.
Yeah. I think that’s very, very profound. And do you use hormones in those patients? Well, what—? Both estrogen and progesterone?
Uzzi Reiss, M.D
Are you talking fertility?
Kent Holtorf, M.D.
Well, with PCOS.
Uzzi Reiss, M.D
PCOS, estrogen nearly all the time. They don’t have enough progesterone, rarely. That’s why they have irregular cycles, they hyper menstruate many times.
Kent Holtorf, M.D.
Yeah. Yeah. They don’t ovulate, they don’t make the progesterone.
Uzzi Reiss, M.D
Exactly. And you want—they have very low sex binding globulin. That’s why they [inaudible]. So, sometimes I’ll give them Estradiol in drop that goes sublingually. When you give it sublingually, one time shoot up and will increase the sex binding globulin and over all decrease the high dose of testosterone.
Kent Holtorf, M.D.
Yeah. Just on sex hormone binding globulin—and I think it’s a marker that doctors just don’t know about. It goes up in response to two things in the liver, estrogen and thyroid— Low thyroid and low estrogen, yeah.
Uzzi Reiss, M.D
Thank you very much. I was honored that you invited me. All the best to you. We’ll see each other. Have a good day.
Kent Holtorf, M.D.
Thanks for taking the time.
Uzzi Reiss, M.D.
Thank you. Bye bye.
Kent Holtorf, M.D.
Apreciate it. Alright, bye, bye. Bye Uzzi. Take care.
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