Researchers have been struggling to find an effective, affordable method to reverse the age of our cells.
A new study unveiled six “chemical cocktails” that could reverse the age of cells in animals.
David A. Sinclair, PhD, and his team at Harvard had previously been able to show that gene therapy could help reverse aging. In the new study, they found six different combinations of small molecules were able to have a similar effect, and it’s much more affordable.
In both mice and monkeys, the researchers found that aging could be reversed in less than a week with these chemical cocktails.
In one news report, Dr. Sinclair stated, “This new discovery offers the potential to reverse aging with a single pill, with applications ranging from improving eyesight to effectively treating numerous age-related diseases.”
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What Are Chemical Cocktails?
A “chemical cocktail” is a mixture of different chemicals. When chemical cocktails get developed for research or medicine, the goal is to have some chemicals amplify the positive effects of others.
Dr. Sinclair and his team intensely studied different chemicals before developing their chemical cocktails. The six chemical cocktails they developed had some incredible results.
These cocktails improved the effectiveness of “nucleocytoplasmic compartmentalization,” or NCC for short. NCC is incredibly important because it facilitates the movement of proteins in and out of the nucleus of a cell. Age-related diseases are linked to dysregulation of NCC.
Basically, these chemical cocktails make your cells healthier. They allow your cells to keep the internal organizers and protein transporters healthy.
However, it is important to note that a lot more work is needed.
Luigi Fontana, MD, PhD, is the chair of Translational Metabolic Health at the Healthy Longevity Program at Sydney University. In one article, Dr. Fontana stated that, “These are just preclinical data that must be validated in well-designed and adequately powered human randomized clinical trials. It is essential to rely on rigorous scientific research and evidence-based studies before drawing conclusions about the effects of such molecules on human health.”
What Happens Next?
The next steps will be very exciting. Clinical trials will tell us:
1) If affordable, small-molecule cocktails can reverse aging in humans
2) If there are specific medical conditions that the chemical cocktails could treat
3) The side effects of the chemical cocktail use in humans
Dr. Sinclair’s study unlocked a new vault of possible solutions to aging.
Effective treatments for age-related diseases and age-related deterioration are much closer than before. Be sure to keep an eye out for the future studies related to the work done by Dr. Sinclair and his team.
It is possible that they have found a path to whole-body rejuvenation.
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References
Yang J, Petty CA, Dixon-McDougall T, Lopez MV, Tyshkovskiy A, Maybury-Lewis S, Tian X, Ibrahim N, Chen Z, Griffin PT, Arnold M, Li J, Martinez OA, et al. 2023. Chemically induced reprogramming to reverse cellular aging. Aging (Albany NY) 15:5966-5989. Read it here.
Mikhail A. 2023. Harvard scientists have identified a drug combo that may reverse aging in just one week: ‘A step towards affordable whole-body rejuvenation’. FortuneWell. Read it here.
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