Mast Cell Activation

Mold

Day 2 Mini Presentation – Reversing Mast Cell Activation and Histamine Intolerance Summit

Reversing Mast Cell Activation and Histamine Intolerance Summit 2022

And this is a great diagram from his paper. So there are three major phases. That's what I want you to see here. So there's cell danger response 1, 2 and three. This cell danger response is really what happens in our bodies when we have an overwhelming number of threats and those threats. We can distill down into primarily three categories toxins. Those can be chemicals, metals, mold toxins, pathogens, bacteria, viruses, parasites of candida, fungal colonization. But fungal colonization and tick borne infections are really big triggers of this and that the third are stressors. And we're talking about stressors, we're talking about emotional stressors, mental stressors, physical stressors, injuries, surgeries were talking about traumas. So when these things all stack up, you know, we can stay ahead, we can stay ahead and navigate. But eventually there's the straw that breaks the camel's back. When that happens, we tip into what's called cell danger response. So this is a response, a metabolic response to protect. So it's protective to protect our bodies all the way down to the cellular level from harm from these stressors, pathogens, toxins. And I think of it like we go into a lockdown response away that you could think about this is that if you had if your body was a really complex factory and a line went down here or a line went down there, you could keep producing things, you could keep the biochemistry is going to keep working. 

You just get that line repaired would be okay. But if a fire breaks out, you're not going to keep running the serial down the line, you're going to shut things down and get that fire out. So one cell danger response is triggered the body goes through and at the cellular level, we go through these different stages. And what this is showing us is that there's a number of biochemical changes required for us to heal. I want you to understand this because there's so many things that people of mast cell activation syndrome are doing to keep backfiring. Backfiring And this is what helps us understand the right order of operations. And I'm going to share a lot more detail about that with you in many presentations I do for you on day seven. 

So I hope you join me then. If you've ever been someone or seen someone who became bedridden after a glutathione ivy or got way worse from high dose method, full aid or methyl B 12, what likely happened was that those things were it's not that those things are bad. They're wonderful healing agents but it's that they introduced likely at the wrong time for that person. And that's really what I want to get at for you in the summit is doing things for the right things in the right order at the right time. Alright so I'm not gonna get into all the in depth of these three phases because Eric Gordon is going to cover that for you. But what we're talking about here is going to set the stage for every talk that you're listening to in a cell danger response. We have these biochemical changes. We get stiffening of cell membranes, methylation changes. We get glutathione production changes. Gene expression changes, vitamin D. Goes down. We get an increase of histamine through what's called H. D. C. 

So our bodies make histamine and then that triggers more mast cell activity and other so called cinephiles. You're going to learn about on day four we have an alteration was called him activity that can produce what's called preference. Trip to fan gets shunted away from making melatonin to these neuro inflammatory compounds that you can imagine. If we're not making melatonin we're gonna sleep well. We start to accumulate metals in the tissues. And all of this is protective. Why would this be happening? Well pathogens enter into ourselves through the cell membrane. So if you stiffen them it's like putting up a castle wall around it and keeping them out certain pathogens will use methylation to replicate. So we cut them off from that. Increasing the mast activity is going to increase the immune response to go after these toxins. 

And these pathogens the metals accumulate become some pathogens feed on metals and you want to tuck those into the tissues to protect yourself not have them being circulating through the bloodstream and excreted through the urine. People even get bowel changes including the micro microbiome. They get mitochondrial changes, talk about sleep cycle and fatigue levels change and you get major epigenetic that means gene expression changes. Any of this sounds like what you're going through. I would imagine at least some of this you can resonate with. So this is why many people who are sensitive with massellis. You struggle with things like fossil title Colin. If that supplements brought into early. Well that's going to start to soften the cell membrane. But if you have pathogens and don't want them getting in Things like high dose methylation support early on can be hard to hard for people to take very sensitive B6 can support an increase of that. Histamine production. 

So some people are fine with it but some people have trouble with it. For some low carbs are a problem and that's where it can affect the heme pathway that I talked about before. Metal detoxing before mold is addressed can be problematic antimicrobials for the gut before getting the mold toxins out with binders, mitochondrial supports too early can backfire. And what's happening is as we if we do this in the wrong order, they can start working against cell danger response. Now, I'm not saying that these are problems for everybody. They're not really talking about the sense of people who are having trouble taking things and figuring out why everything keep backfiring. You want to give you a model for this? So the real problem we talked about yesterday now we're really getting into why cell danger response tells us that mast activation syndrome. These gut imbalances, these hormones, these sleep issues. They're not the problem. 

They are expressions of protective expressions of what's really happening underneath. So really understand the mast cells. What's happening with them is to protect us. It's the underlying pathogens, toxicity stressors, the genetic weaknesses that get highlighted that are the problem. So according to this model, mast activation syndrome is an expression of cell danger response and I like to use this image. This is a block game. And in the scheme, mold and lime are at the bottom. Let's call lime actually tick borne illnesses. Once you get those you start getting stacked up things like nervous system dysregulation mast cell activation cell danger response turns on can get anxiety and SIBO and parasites and Candida and HPA access issues which can lead to things like chronic fatigue, insomnia, viruses like Epstein Barr, thyroid imbalances and other hormone imbalances. 

Many people are getting stuck trying to work too far up here and if we want this whole tower to fall over, which I know that's not the goal in jingle, but that's what we want is we want to get all of these things knocked off the board. It's like the mold, the tick borne infections, the nervous system dis regulation the cell danger response. They've nailed them all down and we've gotta get that nail out and we've got to deal with what's down here at the bottom most route layers and then as you do that, the other things can start to clear up and fall away. So what I'm getting at is that mold and tick borne pathogens are some of the biggest imp actors driving cell danger response along with trauma and chronic stress. So we address those, we can unravel the cell danger response and these biochemical changes can go back to balance. 

So just to recap particular mold toxicity, the tick borne infections, the trauma, the stressors these primary route drivers aren't addressed. It's very hard to fix chronic Epstein barr. It's actually hard to address the tick borne pathogens when mold toxicity hasn't been addressed. It's very hard to get to see bone of the gut issues, hormone imbalances, sleep issues. It's hard to get rid of mast cell activation, histamine intolerance if you're dealing with solicitor lates or dealing with him pathway issues or heavy metals. So I'm gonna be getting into a little more detail about these things that are many presentations as we go. But I want to get you to the talks for today and just a reminder. You can find all of your discount codes, your links and special additional downloads at mastcell360.com/summit, enjoy the talks. I hope you have a wonderful day and I will see you tomorrow

<h6>Beth O’Hara, FN</h6>
Now, here's what we're going to cover today. We're gonna be talking about an introduction to cell danger response, setting the context for today. This is important for you. Even if you're not going to listen to that talk, I want you to understand mast cell activation syndrome from this context. But then if you want to understand this in more depth, you do want to check out Dr. Eric Gordon's talk on it. He's going to go very in depth on cell danger response. So let's look at this a little bit. What is this? This model completely changes how we think about things like mast cell activation syndrome. Now, I'm gonna show you a diagram here and I don't want you to worry about all the words on there. Just want to show this as a visual to capture your attention about How we can think differently about things like mast cell activation syndrome. But let me tell you where this came from. This was developed by Robert Navio and it was first published in his paper, metabolic features of the cell danger response in 2014. This diagram that you see here is from the 2019 paper, incomplete healing as the cause of aging, the role of the Mitochondria and cell danger response.

https://d1tnc8rqovg0h0.cloudfront.net/2022+Summits/Mast+Cell+Summit/Transcripts/Mast+Cell+Summit+2022+-+Beth+O'Hara%2C+FN+Day+2+Mini+Presentation+Transcript+File.pdf

Beth O’Hara is a Functional Naturopath, specializing in complex, chronic cases of Mast Cell Activation Syndrome, Histamine Intolerance, and Mold Toxicity. She is the founder and owner of Mast Cell 360, a Functional Naturopathy Practice designed to look at all factors surrounding health conditions – genetic, epigenetic, biochemical, physiological, environmental, and emotional.

Day 2 Mini Presentation – Reversing Mast Cell Activation and Histamine Intolerance Summit

Beth O’Hara, FN

Summary

Content Provided By

Beth O’Hara, FN