Full Transcript Introduction to Detoxification and Methylation 0:02 Hi everyone, I'm Dr. 0:03 Mima and welcome back to the next episode. 0:07 Today we're going to be talking about detoxification in a lot of detail. 0:12 Uh, today we are going be focused on detox as a function of the body, a very important function in functional medicine. 0:22 It's probably one of most important functions in the And I'll be walking you through all the different detoxification pathways. 0:29 We'll working through this information together. 0:33 And we'll really focus in a lot of detail on methylation. 0:36 I know many of you who are in the functional medicine community or who are patients of functional medicine, you've heard about the word methylation. 0:46 But the majority of the population doesn't know what methyilation is. 0:50 So we're going to dive really deep into that today. 0:52 Probably more information than you're ever going want to know about detox and methyulation, but it'll give you the whole picture, 0:59 the why behind all of this, why we check for these genes and what they really mean, and you can do to identify whether or not you might have a particular 1:10 genomic need for detoxification support. 1:13 Not everyone needs to be doing a heavy detox like this, but when you do have a compromised gene, it makes a lot of sense to understand it, 1:24 identify it and then start to supplement in a way that's truly targeted so that you're not just shooting in the dark. 1:32 You have an approach that is precise and accurate. 1:35 So let's get started. 1:37 So today we're gonna talk about the detoxification pathways from genomics to cellular renewal and how every cell in your body detoxes every second. 1:48 This is not just the liver. 1:50 Every single cell is detoxifying. 1:54 In methylation, this process that we are going to talk today slows down. 1:59 What happens is that toxins start to accumulate inside your And as those toxins accumulate, hormones also start to recirculate and DNA repair starts to falter. 2:14 So tonight, we're going to explore how your genes, your nutrition and your daily rhythm determine your body's ability to cleanse, 2:22 renew and protect itself. 2:25 Remember that every cell in your body performs detoxification. 2:28 They're breaking down hormones, they're processing nutrients and they are clearing out environmental toxins all the time. 2:37 The methylation cycle is the body's master switch for these processes. 2:42 and it links energy and metabolism and also hormonal balance, mood regulation, and longevity. 2:49 So all these really important functions in the body are essentially controlled by this concept of detoxification. 2:57 You can imagine that us humans living in this world today We really have to understand what this is in order to support our longevity because without optimal detoxification, 3:09 we really don't get to live a healthy life or a long life that's healthy. 3:14 So this a key to longevity. 3:19 There are five key genes that we're gonna focus on in this particular session. 3:24 Now, when you do your genomics report, we gonna have many more genes than this because there are multiple different SNPs, 3:31 specifically small nucleotide polymorphisms that you can look at in the detox pathway that give you a lot of information about the body.
Case Study: Symptoms, Labs, and Genomic Clues 3:40 This is just an overview looking at five keys SNP to give some concept in general about what these mean, and how you can start to work with them. 3:50 Together they're going to determine how efficiently your body can methylate, detoxify, and renew. 3:57 So we'll start first with a case study and this might be somebody like you. 4:02 There is a cases that I'm working with of a 44 year old woman who presented with fatigue, insomnia, hormonal imbalances. 4:11 She's got bloating and food sensitivities, chemical and histamine intolerance, a family history of breast cancer and has a high amount of stress and emotional 4:22 exhaustion that she often carries. 4:24 We did some deep labs on her and other providers have also worked with her. 4:29 Oftentimes in functional medicine, we have many labs that people have done and they're coming in with. 4:35 And part of my role is to look at that in a lot more detail as a comprehensive, inertial consultation. 4:43 So we looked and saw that she had elevated MMA and FIGLU. 4:48 These are all part of the blood reproduction and clearing cycles and part hemoglobin. 4:58 So MMOA and figlu were both elevated and they're blocked essentially by methylation. 5:04 I'm sorry, there's a blocked methylation pathway causing it. 5:09 She also had low glutathione and a high lead and mercury, essentially signifying a detoxification overload. 5:17 And these are all the variants that were present when we looked a little further at the genomics. 5:23 She also had been receiving some hormone replacement therapy to try to support her symptoms and also has some histamine intolerance that had developed. 5:34 Again, a key gene that we can test and analyze when we're looking at your genome, we could look at the DAO and the histamines inside the body. 5:46 Now, what this really means is that her detox engine was underpowered and the genes that are responsible for methylation and detoxification in her body 5:56 were all operating below their capacity and leading to fatigue, mood changes and toxin accumulation. 6:04 Once her methyulation and antioxidant pathways were supported, her energy, focus and her sleep started to improve. 6:12 So this is an example of how when you do a deeper dive of the genomics, you can really start to understand what the causes of those symptoms like the fatigue, 6:23 the mood changes, and the toxin accumulation that was leading to her feeling overwhelmed and tired. 6:30 And when treat appropriately, You can change that and suddenly have energy, focus and improved sleep. 6:38 So here's what the methylation cycle really is. 6:41 And again, this is a lot more biochemistry than you probably wanna know, but this the core science behind methylation pathways. 6:50 Again, these are occurring in every single cell in the body, right? 6:54 So they're not just a part of the liver or part a certain organ function, they are happening in everything single cells, 7:02 in this particular cycle. 7:04 So imagine that all the cells in your body are going through this. 7:09 So here we have a methylation cycle, what's called the transulphuration cycle and the folate cycle. 7:15 And they're all connected. 7:16 We're going to break that down and show you what that means in a lot of detail. 7:22 First, there's something called a methionine synthase, which is the number one over here. 7:27 This essentially remethylates homocysteine and turns it into methione. 7:33 In order to do its function as an enzyme, again, inside every single cell, it requires B12 and methyl tetrahydrofolate. 7:42 These are essential co-factors that are needed in order for this enzyme to doing its job. 7:49 The next one is BHMT, which is number 2 here. 7:54 That enzyme actually converts homocysteine into methionine and uses betaine. 8:00 again, a co-factor that you find in your diet and you'll find it in supplements, and this is primarily occurring in the liver and in kidneys. 8:09 The third one, which is number three over here, essentially is responsible for converting homocysteine into cystothionine over there, 8:21 so that's number 3 here. 8:23 This particular enzyme requires B6 and PLP as part of the cofactors for it to function optimally. 8:33 And then there's the famous MTHFR. 8:36 So notice there are other enzymes also part this pathway that we don't talk about as much, but they're equally as important.
Methylation Cycle Overview and Key Enzymes 8:42 Now Mthfr produces methyl tetrahydrofolate. 8:48 This is the number four over here, and that's its job over is to produce this. 8:55 In order to do so, it requires riboflavin and FAD. 9:00 These are also important cofactors that are part of this pathway. 9:05 And then the last but not least, this last enzyme is converting cystothionine to cysteine and glutathione. 9:12 So most of us have heard about glutothione and how important that is for detoxification. 9:18 Well, in order for that to be produced properly in the body, you also need these other co-factors like B6 and PLP that are responsible for its production. 9:29 So this is again coming from some excellent science, relatively new frontiers in nutrition, 2023. And we're going to get into this in a lot more detail, 9:39 but just to really emphasize that this is advanced science, it may not have made it into your primary care doctor's office. 9:48 It is a very common functional medicine focus, and it is very important part of our health and well-being. 9:57 So when we think about our health and our longevity, we really should be also focusing on these detoxification pathways. 10:06 Now, I've only highlighted five key very important snips, but like I said in the beginning, there are many more that are also responsible for those other 10:17 enzymes that we talked about and other aspects of this pathway in every single cell of your body and how detoxication is occurring. 10:27 So, let's get down to the details here. 10:30 Now, MTHFR, that first gene we talked about, is the gatekeeper. 10:35 This is methylene tetrahydrofolate reductase, and it functions by converting folate, vitamin B9, into its active methyl form, 10:47 which is 5MTHF, which donates methyl groups to restart the cycle. 10:53 So without enough methylfolate, the body can't produce SAMe, which is what is called a universal methyl donor. 11:02 This is important for your mood, your focus, because when MTHFR is slow, Because of genetic predispositions, you can have a homozygous or heterozygos mutation 11:14 causing you to have certain variant that is actually causing the enzyme to be depleted or slower. 11:21 You're gonna have reduced methafolate production that causes sluggish methylation. 11:27 you'll have elevated homocysteine which causes inflammation, poor detox of hormones and toxins in neurotransmitters, low energy. 11:37 lots of anxiety and depression, and increased cancer and cardiovascular risk. 11:43 So this is not something that you should ignore. 11:45 And again, I really see this time and time again that primary care doctors are not aware about this risk, but it does make you more susceptible to the 11:56 things I just mentioned. 11:58 So how do you support this pathway? 12:01 You support the pathway by using methylated B vitamins like methylfolate and methylcobalamin. 12:07 You can also use dark leafy greens, beets, and legumes and avoid synthetic folic acid because that can actually block the receptors. 12:18 So you might be taking synthetic folic acid thinking you're doing yourself some good, but if you don't know that you have this gene, 12:25 it can actually be causing problems. 12:28 So MCHFR is the ignition key of methylation. 12:31 If it's slow, the whole engine is going to lag, right? 12:36 So that's why it is one of the first enzymes we talk about and the set of snips that we look at when you are looking at your genome. 12:43 The other two, MTR and MTRR, are also relatively well known but not as commonly as MTHFR, but equally as important. 12:53 So these specific reductase and synthase enzymes, these enzymes are used in vitamin B12 conversion to homocysteine. 13:03 So these enzymes use vitamin B12 to convert homocysteine back to methionine, keeping the methylation cycle moving. 13:15 So you can be giving yourself B-12 and not be getting good results if you don't know what's happening with these particular enzymes. 13:23 MTR needs B 12 to perform its conversion. 13:29 regenerates B12 to keep MTR working. 13:32 When they're sluggish, the homocysteine rises and that causes inflammation and poor circulation. 13:39 When DNA repair slows, there's a higher oxidative stress and cancer risk, energy drops, and there is fatigue and brain fog. 13:48 And often there are neurotransmitter and hormone synthesis that's faltering that causes mood swings and PMS. 13:56 So these are often responsible for mood swing and the neurotransmitters effects that we're looking for when we think about our health and well-being. 14:04 So the gut and the brain are important, but these are also important in terms of neurotransmitter production and how you feel with your mood, 14:14 how your energy is, whether you have focus and concentration, and you're repairing your DNA. 14:20 So these very important functions in the body, right? 14:23 And super important for longevity. 14:26 That's why looking at this part of your genome can be very helpful. 14:31 Now, we support this by using B12. 14:36 B-12 is basically in the form of methylcobalamin, which is the active form, or hydroxyclobalamin which, is gentle for sensitive patients. 14:47 We can support these pathways. 14:49 So, if you're sensitive to normal methylcobalamine, you might want to use hydroxylcabalamine. 14:56 There's also riboflavin B2 that can help recycle B12 efficiently, and choline and betaine like the form of TMG can bypass the pathway if it's sluggish.
MTHFR, MTR, and MTRR: Folate and B12 Support 15:11 So when you're thinking about the genetics of your pathways, once you know that you might have a deficiency, not everyone has this, 15:21 but if you do, then there are targeted ways that we can use nutrients and supplements to essentially promote these pathways in a way that's gonna make 15:33 you start to feel better. 15:37 Next, we're going to look at another very important SNP, which is AHCY. 15:42 This is considered the bridge between methylation and detoxification. 15:47 So this is adenosyl homocystenase, AHcy, and its function is to convert Sa, a precursor, into homocysteine. 16:01 allowing the cycle to then continue. 16:04 Now, if this particular enzyme is slow, then the SA starts to build up and it blocks methylation, like we said earlier. 16:14 It's like a traffic jam in the middle of the detox highway. 16:17 Why this matters is that this AHCY connects methyulation to glutathione production. 16:25 which we know from what we said earlier, glutathione is a master detox molecule in the body. 16:32 So this is the connector between these two pathways. 16:36 When it's slow or low, both methylation and detoxification will stall. 16:43 Things like toxins, hormones, and neurotransmitters start to accumulate in Symptoms of this slowdown essentially show that you could have fatigue despite 16:57 B vitamin use, chemical or medication sensitivity, a poor response to detox supplements, histamine reactions or inflammation flare-ups, 17:06 And to support it, we use magnesium, taurine, NAC and choline to open up those AHCY bridges. 17:16 We can also use sulfur-rich foods like onions, garlic and cruciferous vegetables, and glutathione precursors like vitamin C, 17:25 selenium and glycine. 17:27 AHcY is the biochemical bridge between clean energy and cellular waste removal. 17:36 Next, let's talk about calm T. 17:38 Calm T is the calming gene. 17:41 This is catechol-O-methyltransferase. 17:44 The function of this gene is to use SAMi from methylation to clear cationolamines in the form of dopamine, norepinephrine and estrogen metabolites. 17:55 When calm t is slow, the stress hormones linger longer and anxiety, insomnia and irritability develop. 18:03 When estrogen metabolites build up, PMS, breast tenderness and fibrocystic changes occur, and the mood may swing between focus and overwhelm. 18:14 When calm tea is too fast, catecholamines get cleared too quickly, fatigue gets resulted, as well as low motivation and low dopamine tone. 18:26 So this is another enzyme that we want to focus on when we think about detoxification. 18:32 And how do we support this? 18:33 Well, we can use things like magnesium. 18:37 We can give you supplementary SAMe and also B2 to bring these functions back into balance. 18:45 This is also why you want a limit caffeine and stimulants. 18:48 You might want add nutrients that are calming like glycine, theanine B6 and zinc. 18:56 We'll also want to support estrogen clearance with dim flaxseed and fiber. 19:01 So calm tea regulates how we process life's chemistry in the gene. 19:07 It's a gene basically of calm, focus, and resilience. 19:13 So now there's a lot of information about these top five genes, and this is how they flow in the pathway. 19:20 You'll see here that you've got the MTRR, HCY, COMT, are all involved in the production of glutathione, as well as the methylation of nucleic acids that 19:37 are involved due in DNA reproduction, neurotransmitters, and xenobiotics, So whether it's breakdown of the food that you're eating, 19:50 breakdown toxins, production of neurotransmitters, or the replication of DNA, methylation is a critical part of body. 19:59 And these are the compounds and components that make up that pathway. 20:04 In order for them to function optimally, we really have to be thinking about those nutrients and cofactors that we just talked about. 20:14 So how does methylation detoxification and brain chemistry connect?
AHCY and COMT: Detox, Histamine, and Hormones 20:22 Well, here's how they're connected. 20:25 Folate from greens is converted to methyl tetrahydrofolate. 20:29 So when you eat a bunch of green leafy vegetables, you're getting that folate, right? 20:33 So that fallate needs to then convert into methyl-tetra-hydropholate. 20:38 This step requires the enzyme MTHFR. 20:42 Methyl tetrahydropholate supplies the main methyl fuel that's needed to run the methylation cycle. 20:50 Methionine or the methylation cycle is the second step. 20:56 So the methyl fuel converts amino acid methionine into what's called SAM. 21:01 And SAM is the body's primary methyl donor. 21:05 It supports DNA repair, neurotransmitters, and hormone metabolism. 21:11 So this is how the brain starts to get connected to the detoxification cycles, right? 21:17 SAM as necessary for the production of new brain neurotranmiters, as well as hormone balance. 21:24 So all of this is a very important part of the different pathways around hormones as well as neurotransmitters and brain function, 21:31 brain health. 21:33 Homocysteine must be recycled properly to prevent its buildup because build up of homocystein can be quite harmful. 21:42 And recycling requires vitamin B12, MTR, MTRR enzymes. 21:49 And then there's the trans-sulfuration pathway or detox pathway that we talked about in the beginning, where homocysteine goes down this pathway and it 21:59 turns into cystein that's then used to make methionine. 22:03 So that needs to work optimally, otherwise you have a buildup of homocysteines. 22:07 Glutathione is the final production from cysteine to glutathion, and it's the key antioxidant for detoxification and inflammation control in the body. 22:18 And for this to work properly, we need vitamin B6. 22:21 So this just really emphasizes and shows how important these cofactors are within every single cell in body and how these vitamins are. 22:31 B2, B 6,B9,and B12 are critical to keep methylation running optimally. 22:38 And if any part of this slows down, methylation weakens, detoxification drops, and homocysteine starts to rise. 22:48 So let's get into how all these different genes that we talked about are connected and what are some ways that can actually support them individually. 22:57 To summarize, MTHFR we've talked is one of the most important parts of these pathways. 23:03 Activates folate and starts the methylation. 23:07 If it's underactive, you often have fatigue, high homocysteine buildup, and hormone build up as well. 23:15 So when I often work with people's hormones, I do check the detoxification pathways I prefer to take a look at this because it gives us a lot of input 23:25 and insight on how to support you when you're taking these hormones. 23:29 Otherwise, you can have hormones start to build up in the body and not clear properly if your detoxification pathways are not working well. 23:38 MTHFR also supports methylfolate and leafy greens. 23:44 Next we have MTR, which converts homocysteine into methionine. 23:49 Now when this is not working properly, you have fatigue, anxiety, and inflammation. 23:55 And what supports it best is B12, folate, and beta-ene. 24:00 So these are things that we can get in our food or take as supplements to support this particular enzyme and to prevent the fatigue and anxiety and the inflammation. 24:10 You can see that that is a common part of the symptoms of fatigue in both the pathways. 24:17 In MTRR as well, you're seeing low energy and poor detox because this is important for regenerating B-12 in order to use it in the MTR. 24:28 So to treat low M-T-R-r, we'd want to give B12, right? 24:34 So B-12 hydroxymethyl forms are important, and also B2 is another enzyme that you can use, I'm sorry, another cofactor that she can used to support this enzyme. 24:47 Next is AHCY. 24:49 This converts SAH into homocysteine. 24:55 So this particular enzyme is responsible for detoxification and congestion of that occurs when it's not functioning optimally. 25:05 You can have a histamine overload. 25:09 also when that's not functioning properly. 25:12 How do we treat it? 25:13 Well, oftentimes magnesium, NAC and taurine can be quite helpful in patients with this particular mutation. 25:23 And then the next one is calm tea. 25:25 This clears dopamine, estrogen and stress hormones. 25:30 When it's no functioning optimally, we have anxiety, PMS and sleep issues. 25:35 And to support it, we will give magnesium, salmi, B6, calm, and make sure the environment is calm.
Applying the Pathways to the Case Study 25:44 Not just calm the supplement. 25:46 So calm tea can be very helpful when functioning optimally to prevent anxiety, PMS, sleep disturbances. 25:57 Now let's go back to our case that we started with, that 44-year-old woman. 26:01 Now in this patient, she had MTHFR and MTR variants that were showing slow methylation, causing fatigue and also changes in the red blood cell size, 26:12 mastocytosis. 26:15 AHCY variant was also present causing a methylated backup and low glutathione. 26:20 COMT showed slow variants that led to estrogen buildup, causing some of her symptoms in terms of hormones, and MTR variants impaired recycling, 26:31 creating elevated homocysteine and inflammation. 26:36 So what's the outcome? 26:39 When these pathways were supported with methylated nutrients like B12 and folate and magnesium and sulfur foods as well as antioxidants, 26:48 She had clearer energy, better sleep, improved digestion, fewer histamine reactions, and a more stable mood. 26:56 So how do you support these pathways? 26:59 That's really the bottom line for this lecture is, what can we do? 27:04 So certainly there are detoxification protocols, when you work one-on-one with a provider, you get your genomics done, and we can have a much more customized 27:14 approach for your detoxication protocols. 27:17 In part two of our webinar series, in the Mastermind series Next year, I'll be sharing with you proprietary protocols for those who end up signing up for 27:28 the Mastermind membership. 27:31 We'll get into a lot more interesting detail there as well about ways to treat these different parts of detoxification. 27:41 But a very general approach that I think everyone can start with that doesn't require a genomics and customization is eating a rainbow of vegetables. 27:53 So when you eat the rainbow, you're getting all kinds of antioxidants and minerals, and we're feeding that detox enzyme pathway. 28:02 You also want to hydrate very well because water is your detox transport system. 28:08 Without water, we are not able to flush out the toxins that come through the detox pathways. 28:15 We need to move daily. 28:16 Sweating and circulation keep that lymphatic system clear. 28:21 So exercise all the time, daily, as much as possible, sweating, going to the sauna, the steam room, all very helpful. 28:31 Sleeping seven to eight hours every night. 28:34 Remember that your liver's detoxification pathways are optimal overnight. 28:40 So if you're not getting that overnight sleep, you are going to be losing those key detox hours overnight, and then breathe slowly. 28:50 Stress directly suppresses methylation. 28:53 You want to breathe very slowly when you working on your detoxifications and reduce that stress. 29:03 Now, what are some of the things you can do from a nutrition standpoint to help support these pathways and target detoxification? 29:12 You can't forget the protein, because protein in particular in the form of amino acids, we talked about the glycine, the cysteine.
Lifestyle and Nutritional Support for Detox 29:20 These are amino acid that are needed to create those cofactors and also to the enzymes that required in detoxifications. 29:28 They're actually made out of proteins and amino acids so we cannot ignore the importance of having optimal protein. 29:38 Cucifers like broccoli, kale, cabbage, These are also known as sulfurophanes. 29:45 Remember, we talked about the trans-sulfuration pathway. 29:50 This is why we wanna have cusifers in our diet. 29:54 Broccoli, kale, and cabbage are great for detoxification. 29:58 For those who are doing the Kosher Ayurvedic Health Program, I often encourage people to cook their cusefers to reduce the impact of having the extra raw 30:10 varieties on the systems of hormones like the thyroid. 30:15 Beets and greens are also wonderful and they are serving as methyl donors in these pathways. 30:22 So folate and betaine are coming from the beets in the greens. 30:27 And then having healthy fats supporting bile flow like olive oil and avocado are very important. 30:35 Fiber to bind to the toxins and to promote elimination. 30:40 You might want to also have some supplements to support you in the detoxification. 30:45 I often recommend some basic supplements for people once I know what's happening with your genome and understanding your health. 30:53 We can get more specific with the supplements, but this is a great start. 30:58 and it provides you with what you need in order to get going. 31:01 So activated B complex like B12, folate, B2, and B6, magnesium glycinate can be very helpful, NAC, vitamin C, selenium for glutathione support, 31:14 then having a sulfurofane like broccoli sprouts extract, as well as calcium deglutarate or DIM for hormonal metabolism. 31:23 For those of you who are part of the Mimosa community, I'll also be posting the full script link so that you can go ahead and see which supplements I recommend 31:34 for the community on the Substack newsletter. 31:38 So if you're not already signed up for that, encourage you to look at MIMOSA Longevity and Substac. 31:44 and you will be able to find the link to be to access these particular nutrients in case you'd like to do a detoxification for yourself. 31:56 Now, I've included some important references that are also available if you'd like to dive deeper into detoxification. 32:07 Some of the ones were referenced in this article. 32:10 Other ones are just key references to think about, including the importance of methylation and oxidative stress in chronic disease and also in cancer. 32:20 So again, very important to start to around detoxification and how, although it's something you can do on an everyday basis, 32:32 it does have some very deep and important roles in terms of cellular physiology, health, and longevity. 32:41 Think about it this way. 32:43 Your methylation genes are your body's blueprint for detoxication and repair. 32:50 When MTHFR, MTRR, HCY and COMT and also MDR are working in harmony, your body's systems become self-cleansing.
References, Takeaways, and Upcoming Hormone Lecture 33:05 Your mood, energy, hormones and longevity then start to flow together. 33:12 So it's important for us to understand what's going on underneath. 33:18 And this is kind of what I call looking under the hood to see what your detoxification pathways look like so that we can understand why symptoms are showing 33:27 up the way they are in you, why you might be more prone to certain diseases or certain viruses or pathogens. 33:34 All of that is often controlled and moderated by the detoxification pathways. 33:41 So once we know what's going on there, we can optimize those pathways and help you start to feel better. 33:50 Thank you so much for listening to today's episode on detoxification. 33:53 I'm Dr. 33:54 Meema Geer. 33:55 Again, this is the Mastermind series. 33:57 This is third of the year so far on Detoxification, the last two series were on personalized nutrition and circadian rhythm. 34:07 Those are available on the Substack as well. 34:09 Please go ahead and subscribe to the Mansa Longevity Substacks so you can stay connected and see all the information that's being released. 34:18 The next week, I want to just bring to your attention that we will be talking about This is going to be November 13th lecture, 34:31 how stress and hormones are important and how nourishment can actually balance those. 34:37 So we'll get into hormonal health in a lot of detail. 34:40 It's going be an exciting lecture talking about hormones like cortisol, thyroid and sex hormones, their interplay between stress, 34:48 diet and trauma. 34:49 And some key takeaways, like how stress reshapes hormonal balance, how food stabilizes the nervous system, and some practices for resilience. 35:00 Setting your nervous back into a state of reset right before Thanksgiving. 35:05 So that'll be our November lecture before Thanksgivings, so please don't miss that one. 35:11 We will not have the second November Lecture because we're taking a little break for Thanksgiving holidays. 35:16 and then we'll return for our last lecture in December, which is the fifth of the series. 35:23 Looking forward to seeing you next time when we talk more about hormones. 35:26 I'm Dr. 35:26 Meemah Gheer, and today's exciting episode of detoxification, all that you'd ever want to know about how methylation pathways and the detoxication genomic 35:37 snips work, I look forward seeing at the next mastermind.
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