Full Transcript Estradiol and Early Water Retention 0:02 Oh, the skin on my arms, my forearms so 0:02 Oh, the skin on my arms, my forearms so um thin or creepy because it actually 0:05 um thin or creepy because it actually 0:05 um thin or creepy because it actually looks a little bit more plump because 0:06 looks a little bit more plump because 0:06 looks a little bit more plump because it's holding on to that water into the 0:08 it's holding on to that water into the 0:08 it's holding on to that water into the muscle cell. 0:12 muscle cell. 0:12 muscle cell. Does estradile cause weight gain? What 0:14 Does estradile cause weight gain? What 0:14 Does estradile cause weight gain? What women on HRT need to know? Hi, I'm Dr. 0:17 women on HRT need to know? Hi, I'm Dr. 0:17 women on HRT need to know? Hi, I'm Dr. Valerie Davidson from the Progress Your 0:19 Valerie Davidson from the Progress Your 0:19 Valerie Davidson from the Progress Your Health podcast. 0:19 Health podcast. 0:19 Health podcast. >> And I'm Dr. Mackey from the Progressive 0:21 >> And I'm Dr. Mackey from the Progressive 0:21 >> And I'm Dr. Mackey from the Progressive Health podcast. Uh now, if there's ever 0:23 Health podcast. Uh now, if there's ever 0:24 Health podcast. Uh now, if there's ever a more um need to know or want to know 0:27 a more um need to know or want to know 0:27 a more um need to know or want to know controversial topic, I think this one's 0:29 controversial topic, I think this one's 0:29 controversial topic, I think this one's it. Oh, absolutely. I know when I'm 0:31 it. Oh, absolutely. I know when I'm 0:31 it. Oh, absolutely. I know when I'm talking with a patient and we might be 0:33 talking with a patient and we might be 0:33 talking with a patient and we might be talking about possibly introducing HRT, 0:35 talking about possibly introducing HRT, 0:35 talking about possibly introducing HRT, their first question is, "Am I going to 0:38 their first question is, "Am I going to 0:38 their first question is, "Am I going to gain weight?" And I always say, "No, 0:40 gain weight?" And I always say, "No, 0:40 gain weight?" And I always say, "No, that's the goal is not to gain weight, 0:42 that's the goal is not to gain weight, 0:42 that's the goal is not to gain weight, maybe to to lose weight, you know, 0:44 maybe to to lose weight, you know, 0:44 maybe to to lose weight, you know, because estradile can be a very slimming 0:46 because estradile can be a very slimming 0:46 because estradile can be a very slimming hormone." But I think sometimes it gets 0:48 hormone." But I think sometimes it gets 0:48 hormone." But I think sometimes it gets a bad rap where people think that it 0:50 a bad rap where people think that it 0:50 a bad rap where people think that it causes weight gain. But that's where we 0:52 causes weight gain. But that's where we 0:52 causes weight gain. But that's where we kind of wanted to break down a few of 0:53 kind of wanted to break down a few of 0:53 kind of wanted to break down a few of the fundamentals here. I mean, there's 0:55 the fundamentals here. I mean, there's 0:55 the fundamentals here. I mean, there's so much more we could go into, but a few 0:57 so much more we could go into, but a few 0:57 so much more we could go into, but a few few concepts that might make it seem 0:59 few concepts that might make it seem 0:59 few concepts that might make it seem like it's causing weight gain, but it's 1:02 like it's causing weight gain, but it's 1:02 like it's causing weight gain, but it's probably may not be. Now, everybody's 1:04 probably may not be. Now, everybody's 1:04 probably may not be. Now, everybody's different. Every individual varies, but 1:07 different. Every individual varies, but 1:07 different. Every individual varies, but I do know with estradiol is it has an 1:10 I do know with estradiol is it has an 1:10 I do know with estradiol is it has an effect on the kidneys and the kidneys 1:11 effect on the kidneys and the kidneys 1:12 effect on the kidneys and the kidneys will retain sodium. And with sodium, 1:15 will retain sodium. And with sodium, 1:15 will retain sodium. And with sodium, water follows sodium. So, you'll get 1:16 water follows sodium. So, you'll get 1:16 water follows sodium. So, you'll get some water weight. That's why women will 1:18 some water weight. That's why women will 1:18 some water weight. That's why women will say their rings are tight or their face 1:20 say their rings are tight or their face 1:20 say their rings are tight or their face looks fuller or they can notice lines on 1:23 looks fuller or they can notice lines on 1:23 looks fuller or they can notice lines on their where their socks were, you know, 1:25 their where their socks were, you know, 1:25 their where their socks were, you know, on their ankles and that's because there 1:27 on their ankles and that's because there 1:27 on their ankles and that's because there can be some aspect of water weight when 1:29 can be some aspect of water weight when 1:29 can be some aspect of water weight when you're first introducing estradiol.
Why Estradiol Can Seem Like Weight Gain 1:31 you're first introducing estradiol. 1:31 you're first introducing estradiol. >> Yeah. Now, you want to be careful and 1:32 >> Yeah. Now, you want to be careful and 1:32 >> Yeah. Now, you want to be careful and not reduce sodium too much. Sodium is 1:34 not reduce sodium too much. Sodium is 1:34 not reduce sodium too much. Sodium is >> Oh, don't reduce any sodium. Yeah. 1:36 >> Oh, don't reduce any sodium. Yeah. 1:36 >> Oh, don't reduce any sodium. Yeah. >> Sodium is uh sodium is necessary. This 1:39 >> Sodium is uh sodium is necessary. This 1:39 >> Sodium is uh sodium is necessary. This is just more of a response to the 1:41 is just more of a response to the 1:41 is just more of a response to the introduction of the estradiol which you 1:43 introduction of the estradiol which you 1:43 introduction of the estradiol which you don't really have a lot of control over. 1:45 don't really have a lot of control over. 1:45 don't really have a lot of control over. Um, some women are going to gain a 1:47 Um, some women are going to gain a 1:47 Um, some women are going to gain a little bit of weight, um, water 1:48 little bit of weight, um, water 1:48 little bit of weight, um, water retention weight, and some are not. 1:49 retention weight, and some are not. 1:50 retention weight, and some are not. >> Yep. That's why the 1:50 >> Yep. That's why the 1:50 >> Yep. That's why the >> You can't Sorry. You can't predict on 1:52 >> You can't Sorry. You can't predict on 1:52 >> You can't Sorry. You can't predict on who's that who that's going to be 1:54 who's that who that's going to be 1:54 who's that who that's going to be >> because I forgot to mention the breasts 1:56 >> because I forgot to mention the breasts 1:56 >> because I forgot to mention the breasts can feel a little bit fuller and they'll 1:57 can feel a little bit fuller and they'll 1:57 can feel a little bit fuller and they'll say, "Oh, you know, I have some breast 1:59 say, "Oh, you know, I have some breast 1:59 say, "Oh, you know, I have some breast tenderness." It might not be that the 2:00 tenderness." It might not be that the 2:00 tenderness." It might not be that the estradiol dose is too high because it's 2:03 estradiol dose is too high because it's 2:03 estradiol dose is too high because it's just starting. Is it could be because of 2:05 just starting. Is it could be because of 2:05 just starting. Is it could be because of that water retention? But like, yeah, 2:07 that water retention? But like, yeah, 2:07 that water retention? But like, yeah, like Dr. Mackey says, please have your 2:09 like Dr. Mackey says, please have your 2:09 like Dr. Mackey says, please have your goods your electrolytes, your good sea 2:11 goods your electrolytes, your good sea 2:11 goods your electrolytes, your good sea salt. Don't don't stop that. it might be 2:14 salt. Don't don't stop that. it might be 2:14 salt. Don't don't stop that. it might be a little bit more about dosage. So if 2:15 a little bit more about dosage. So if 2:15 a little bit more about dosage. So if you're just introducing estradiol into a 2:17 you're just introducing estradiol into a 2:17 you're just introducing estradiol into a woman that hasn't had any estradi or 2:19 woman that hasn't had any estradi or 2:19 woman that hasn't had any estradi or hasn't done any HR HRT, then they might 2:22 hasn't done any HR HRT, then they might 2:22 hasn't done any HR HRT, then they might have a more exaggerated response of that 2:25 have a more exaggerated response of that 2:25 have a more exaggerated response of that water weight. So you might want to go a 2:27 water weight. So you might want to go a 2:27 water weight. So you might want to go a little low and slow and work your way 2:28 little low and slow and work your way 2:28 little low and slow and work your way up. Oh, again this is for educational 2:31 up. Oh, again this is for educational 2:31 up. Oh, again this is for educational purposes, not for medical advice. We 2:33 purposes, not for medical advice. We 2:33 purposes, not for medical advice. We have that out there. But just some ideas 2:35 have that out there. But just some ideas 2:35 have that out there. But just some ideas when you're trying to avoid or minimize 2:37 when you're trying to avoid or minimize 2:37 when you're trying to avoid or minimize that water weight. Now women in 2:39 that water weight. Now women in 2:39 that water weight. Now women in pmenopause because their estradile is 2:41 pmenopause because their estradile is 2:41 pmenopause because their estradile is going up and down from their own ovaries 2:44 going up and down from their own ovaries 2:44 going up and down from their own ovaries they might notice water weight going up 2:46 they might notice water weight going up 2:46 they might notice water weight going up down and that is from their own estrogen 2:48 down and that is from their own estrogen 2:48 down and that is from their own estrogen but when you're doing HRT introducing 2:50 but when you're doing HRT introducing 2:50 but when you're doing HRT introducing estradiol you can have that water
Insulin Sensitivity, Glycogen, and Body Composition 2:52 estradiol you can have that water 2:52 estradiol you can have that water weight. 2:53 weight. 2:53 weight. >> Yeah. Uh now 2:55 >> Yeah. Uh now 2:55 >> Yeah. Uh now uh overall like you said estro estrogen 2:57 uh overall like you said estro estrogen 2:57 uh overall like you said estro estrogen is very uh a very uh weight a weight 3:02 is very uh a very uh weight a weight 3:02 is very uh a very uh weight a weight positive hormone right that's why a 3:04 positive hormone right that's why a 3:04 positive hormone right that's why a woman's going to weigh less at 25 than 3:06 woman's going to weigh less at 25 than 3:06 woman's going to weigh less at 25 than she does at 55 so it keeps you insulin 3:09 she does at 55 so it keeps you insulin 3:09 she does at 55 so it keeps you insulin sensitive now as you are transitioning 3:11 sensitive now as you are transitioning 3:11 sensitive now as you are transitioning into menopause you are automatically 3:13 into menopause you are automatically 3:13 into menopause you are automatically without even trying you're becoming more 3:15 without even trying you're becoming more 3:15 without even trying you're becoming more insulin resistant so starting HRT is 3:18 insulin resistant so starting HRT is 3:18 insulin resistant so starting HRT is actually a very good thing starting 3:19 actually a very good thing starting 3:19 actually a very good thing starting estrogen is going to minimize some of 3:22 estrogen is going to minimize some of 3:22 estrogen is going to minimize some of that um uh you know u 3:26 that um uh you know u 3:26 that um uh you know u increase in insulin resistance. 3:28 increase in insulin resistance. 3:28 increase in insulin resistance. >> And speaking of that, that's another 3:30 >> And speaking of that, that's another 3:30 >> And speaking of that, that's another aspect that women will notice in terms 3:32 aspect that women will notice in terms 3:32 aspect that women will notice in terms of the scale going up and saying, "I'm 3:34 of the scale going up and saying, "I'm 3:34 of the scale going up and saying, "I'm gaining weight on this estradile because 3:36 gaining weight on this estradile because 3:36 gaining weight on this estradile because what happens is the estradile helps your 3:40 what happens is the estradile helps your 3:40 what happens is the estradile helps your or it basically directs or it improves 3:42 or it basically directs or it improves 3:42 or it basically directs or it improves your insulin sensitivity in your muscle 3:44 your insulin sensitivity in your muscle 3:44 your insulin sensitivity in your muscle cells. So your muscles can those cells 3:47 cells. So your muscles can those cells 3:47 cells. So your muscles can those cells can grab glucose, blood sugar, right out 3:49 can grab glucose, blood sugar, right out 3:49 can grab glucose, blood sugar, right out of your bloodstream and put it right 3:51 of your bloodstream and put it right 3:51 of your bloodstream and put it right into the muscle cell and store it as 3:52 into the muscle cell and store it as 3:52 into the muscle cell and store it as glycogen. It's not fat. It's stored 3:55 glycogen. It's not fat. It's stored 3:55 glycogen. It's not fat. It's stored fuel, but it's not fat. Then your 3:57 fuel, but it's not fat. Then your 3:57 fuel, but it's not fat. Then your pancreas doesn't have to pump out so 3:58 pancreas doesn't have to pump out so 3:58 pancreas doesn't have to pump out so much insulin, which is then going to 4:00 much insulin, which is then going to 4:00 much insulin, which is then going to further propagate weight gain because 4:02 further propagate weight gain because 4:02 further propagate weight gain because insulin is the only hormone that causes 4:04 insulin is the only hormone that causes 4:04 insulin is the only hormone that causes direct weight gain. But let's say you're 4:07 direct weight gain. But let's say you're 4:07 direct weight gain. But let's say you're pulling in that glyco, you're pulling in 4:08 pulling in that glyco, you're pulling in 4:08 pulling in that glyco, you're pulling in that glucose into that muscle cell. You 4:10 that glucose into that muscle cell. You 4:10 that glucose into that muscle cell. You know, you're lowering your blood sugar, 4:12 know, you're lowering your blood sugar, 4:12 know, you're lowering your blood sugar, which is a really good thing. But at the 4:14 which is a really good thing. But at the 4:14 which is a really good thing. But at the same time, glycogen holds on to water. 4:17 same time, glycogen holds on to water. 4:17 same time, glycogen holds on to water. So women will notice over time. They're 4:19 So women will notice over time. They're 4:19 So women will notice over time. They're like, "The scale is still up five pounds 4:21 like, "The scale is still up five pounds 4:21 like, "The scale is still up five pounds or three pounds." I'm telling them, it's 4:23 or three pounds." I'm telling them, it's 4:23 or three pounds." I'm telling them, it's not fat. It's really because you're able 4:26 not fat. It's really because you're able 4:26 not fat. It's really because you're able to pull that glucose into your muscle 4:28 to pull that glucose into your muscle 4:28 to pull that glucose into your muscle cell and you can use it. Go work out, 4:30 cell and you can use it. Go work out, 4:30 cell and you can use it. Go work out, you know, go exercise. It's a good 4:31 you know, go exercise. It's a good 4:31 you know, go exercise. It's a good thing. It's actually increasing or being 4:34 thing. It's actually increasing or being 4:34 thing. It's actually increasing or being beneficial to your metabolic health 4:35 beneficial to your metabolic health 4:35 beneficial to your metabolic health overall. But there is that aspect of 4:38 overall. But there is that aspect of 4:38 overall. But there is that aspect of again water weight in your muscles. I 4:40 again water weight in your muscles. I 4:40 again water weight in your muscles. I will say just on a quick note, I know 4:42 will say just on a quick note, I know 4:42 will say just on a quick note, I know I'm going on and on here, but that women 4:44 I'm going on and on here, but that women 4:44 I'm going on and on here, but that women like it when their glycogen is full from
Fat Redistribution in Menopause and HRT 4:47 like it when their glycogen is full from 4:47 like it when their glycogen is full from that water, from that estradile. They'll 4:48 that water, from that estradile. They'll 4:48 that water, from that estradile. They'll say, "Oh, the skin on my arms here 4:50 say, "Oh, the skin on my arms here 4:50 say, "Oh, the skin on my arms here looking at my forearms doesn't seem like 4:53 looking at my forearms doesn't seem like 4:53 looking at my forearms doesn't seem like so um thin or creepy because it actually 4:56 so um thin or creepy because it actually 4:56 so um thin or creepy because it actually looks a little bit more plump because 4:57 looks a little bit more plump because 4:57 looks a little bit more plump because it's holding on to that water into the 4:59 it's holding on to that water into the 4:59 it's holding on to that water into the muscle cell." 5:01 muscle cell." 5:01 muscle cell." >> Yeah. Now, um again, woman doesn't 5:04 >> Yeah. Now, um again, woman doesn't 5:04 >> Yeah. Now, um again, woman doesn't necessarily care too much where the 5:06 necessarily care too much where the 5:06 necessarily care too much where the weight is coming from. after you've gone 5:08 weight is coming from. after you've gone 5:08 weight is coming from. after you've gone from 135 or 140 and you've gained 5 lbs. 5:11 from 135 or 140 and you've gained 5 lbs. 5:12 from 135 or 140 and you've gained 5 lbs. Either way, the scale has gone up. Okay. 5:14 Either way, the scale has gone up. Okay. 5:14 Either way, the scale has gone up. Okay. Um 5:15 Um 5:15 Um >> but they'll say, you know, my my body it 5:18 >> but they'll say, you know, my my body it 5:18 >> but they'll say, you know, my my body it looks better. Like they'll say, even 5:19 looks better. Like they'll say, even 5:19 looks better. Like they'll say, even though the scale is different, my body 5:21 though the scale is different, my body 5:21 though the scale is different, my body looks better. And that's because, you 5:22 looks better. And that's because, you 5:22 looks better. And that's because, you know, we're not chasing a number on the 5:24 know, we're not chasing a number on the 5:24 know, we're not chasing a number on the scale. Take it in the backyard, dig a 5:26 scale. Take it in the backyard, dig a 5:26 scale. Take it in the backyard, dig a hole, and bury your scale because it's 5:29 hole, and bury your scale because it's 5:29 hole, and bury your scale because it's messes with our psychology. It's really 5:31 messes with our psychology. It's really 5:31 messes with our psychology. It's really about being strong. Like what is it? Um 5:33 about being strong. Like what is it? Um 5:33 about being strong. Like what is it? Um skinny is a new strong 5:34 skinny is a new strong 5:34 skinny is a new strong >> or strong is a new skinny. 5:36 >> or strong is a new skinny. 5:36 >> or strong is a new skinny. >> Yeah. strong as it is getting especially 5:38 >> Yeah. strong as it is getting especially 5:38 >> Yeah. strong as it is getting especially now in the world and we'll talk about 5:40 now in the world and we'll talk about 5:40 now in the world and we'll talk about this uh in a couple of episodes. We're 5:42 this uh in a couple of episodes. We're 5:42 this uh in a couple of episodes. We're going to talk about how to minimize some 5:44 going to talk about how to minimize some 5:44 going to talk about how to minimize some of this weight gain and how to get rid 5:45 of this weight gain and how to get rid 5:45 of this weight gain and how to get rid of it if you have it. Um but in the 5:48 of it if you have it. Um but in the 5:48 of it if you have it. Um but in the world of GLPs, 5:50 world of GLPs, 5:50 world of GLPs, some of those things, you know, you're 5:52 some of those things, you know, you're 5:52 some of those things, you know, you're trying to solve one problem but 5:54 trying to solve one problem but 5:54 trying to solve one problem but potentially creating other problems, you 5:56 potentially creating other problems, you 5:56 potentially creating other problems, you know, depending on what's going on 5:57 know, depending on what's going on 5:57 know, depending on what's going on there, that could be, you know, very 5:59 there, that could be, you know, very 5:59 there, that could be, you know, very detrimental down the road depending on, 6:01 detrimental down the road depending on, 6:01 detrimental down the road depending on, you know, what the situation is. 6:02 you know, what the situation is. 6:02 you know, what the situation is. >> What What do you mean by that? Oh, as 6:04 >> What What do you mean by that? Oh, as 6:04 >> What What do you mean by that? Oh, as far as um how you lose weight and how 6:07 far as um how you lose weight and how 6:08 far as um how you lose weight and how you approach that, whether you're using 6:09 you approach that, whether you're using 6:09 you approach that, whether you're using a GLP or not, you know, that's what one 6:12 a GLP or not, you know, that's what one 6:12 a GLP or not, you know, that's what one of our future episodes are going to be 6:13 of our future episodes are going to be 6:13 of our future episodes are going to be kind of discussing that. 6:14 kind of discussing that. 6:14 kind of discussing that. >> We'll talk about menopause and GLPs and 6:16 >> We'll talk about menopause and GLPs and 6:16 >> We'll talk about menopause and GLPs and you know, proper ways to do that. One 6:18 you know, proper ways to do that. One 6:18 you know, proper ways to do that. One other aspect that women will notice too 6:21 other aspect that women will notice too 6:21 other aspect that women will notice too when they're taking estradi is which is 6:23 when they're taking estradi is which is 6:23 when they're taking estradi is which is a good thing is estradi redistributes 6:26 a good thing is estradi redistributes 6:26 a good thing is estradi redistributes where you're going to gain weight. So 6:28 where you're going to gain weight. So 6:28 where you're going to gain weight. So when the estrogen goes down, this 6:30 when the estrogen goes down, this 6:30 when the estrogen goes down, this happens in late pmenopause and 6:32 happens in late pmenopause and 6:32 happens in late pmenopause and pmenopause also and menopause that 6:35 pmenopause also and menopause that 6:35 pmenopause also and menopause that estrogen goes down, the body, if you're 6:37 estrogen goes down, the body, if you're 6:37 estrogen goes down, the body, if you're going to gain weight, wants to put it 6:39 going to gain weight, wants to put it 6:39 going to gain weight, wants to put it around your organs in the form of 6:40 around your organs in the form of 6:40 around your organs in the form of visceral fat or visceral atapost tissue, 6:42 visceral fat or visceral atapost tissue, 6:42 visceral fat or visceral atapost tissue, which is a very inflammatory that's a 6:44 which is a very inflammatory that's a 6:44 which is a very inflammatory that's a high-risisk factor for reducing your 6:46 high-risisk factor for reducing your 6:46 high-risisk factor for reducing your metabolic health, for diabetes, for 6:48 metabolic health, for diabetes, for 6:48 metabolic health, for diabetes, for cancer, for heart disease, for 6:50 cancer, for heart disease, for 6:50 cancer, for heart disease, for osteoporosis. We do not want visceral 6:52 osteoporosis. We do not want visceral 6:52 osteoporosis. We do not want visceral fat. So when you have that estradiol in 6:55 fat. So when you have that estradiol in 6:55 fat. So when you have that estradiol in your system, it's going to redirect it 6:57 your system, it's going to redirect it 6:57 your system, it's going to redirect it more towards like your muffin top, your 6:59 more towards like your muffin top, your 6:59 more towards like your muffin top, your um your bum, your thighs, your hips. 7:02 um your bum, your thighs, your hips. 7:02 um your bum, your thighs, your hips. >> Yeah. Um so it's it's really just how 7:06 >> Yeah. Um so it's it's really just how 7:06 >> Yeah. Um so it's it's really just how where your body stores the fat. Now the 7:08 where your body stores the fat. Now the 7:08 where your body stores the fat. Now the big difference though, why that's 7:10 big difference though, why that's 7:10 big difference though, why that's important. Now granted just said a 7:11 important. Now granted just said a 7:11 important. Now granted just said a little while ago, if the scale still 7:13 little while ago, if the scale still 7:13 little while ago, if the scale still goes up, we don't want that. But it's 7:16 goes up, we don't want that. But it's 7:16 goes up, we don't want that. But it's better in the short term to have more 7:18 better in the short term to have more 7:18 better in the short term to have more subcutaneous fat than it is to have more 7:21 subcutaneous fat than it is to have more 7:21 subcutaneous fat than it is to have more visceral fat accumulation because the 7:23 visceral fat accumulation because the 7:23 visceral fat accumulation because the longer that happens, the more uh 7:26 longer that happens, the more uh 7:26 longer that happens, the more uh delterious effects there could be from 7:27 delterious effects there could be from 7:27 delterious effects there could be from that.
Looking at the Big Picture on HRT and Weight 7:28 that. 7:28 that. >> Yeah. And I'll have patients and we I 7:29 >> Yeah. And I'll have patients and we I 7:29 >> Yeah. And I'll have patients and we I laugh with them a little bit because 7:31 laugh with them a little bit because 7:31 laugh with them a little bit because we'll look at their blood work, their 7:32 we'll look at their blood work, their 7:32 we'll look at their blood work, their metabolic blood work, and it looks 7:34 metabolic blood work, and it looks 7:34 metabolic blood work, and it looks amazing and I'll say, "Well, that 7:36 amazing and I'll say, "Well, that 7:36 amazing and I'll say, "Well, that that's, you know, that vanity fat that 7:38 that's, you know, that vanity fat that 7:38 that's, you know, that vanity fat that you have is just literally vanity fat. 7:40 you have is just literally vanity fat. 7:40 you have is just literally vanity fat. It's not visceral fat, which is 7:42 It's not visceral fat, which is 7:42 It's not visceral fat, which is inflammatory, which can create, you 7:44 inflammatory, which can create, you 7:44 inflammatory, which can create, you know, long-term health conditions down 7:45 know, long-term health conditions down 7:45 know, long-term health conditions down the road. 7:46 the road. 7:46 the road. >> Yeah. Now, we're not trying to minimize 7:47 >> Yeah. Now, we're not trying to minimize 7:47 >> Yeah. Now, we're not trying to minimize whether it's vanity fat or visceral fat. 7:50 whether it's vanity fat or visceral fat. 7:50 whether it's vanity fat or visceral fat. Um fat accumulation is fat accumulation. 7:52 Um fat accumulation is fat accumulation. 7:52 Um fat accumulation is fat accumulation. Yeah. Right. We don't um uh not 7:54 Yeah. Right. We don't um uh not 7:54 Yeah. Right. We don't um uh not minimizing the you know, the 7:56 minimizing the you know, the 7:56 minimizing the you know, the significance of that. However, 7:58 significance of that. However, 7:58 significance of that. However, metabolically and what it means um that 8:01 metabolically and what it means um that 8:01 metabolically and what it means um that you know, when it redistributes that 8:03 you know, when it redistributes that 8:03 you know, when it redistributes that way, um that's still a positive thing 8:05 way, um that's still a positive thing 8:05 way, um that's still a positive thing even though the scale it might have 8:07 even though the scale it might have 8:07 even though the scale it might have might have gone up a little bit. And 8:08 might have gone up a little bit. And 8:08 might have gone up a little bit. And some women are really sensitive to 8:10 some women are really sensitive to 8:10 some women are really sensitive to estradi when I put them on a little bit 8:12 estradi when I put them on a little bit 8:12 estradi when I put them on a little bit of estradi. And all of a sudden they're 8:13 of estradi. And all of a sudden they're 8:13 of estradi. And all of a sudden they're like, I feel like I've gained weight. 8:14 like, I feel like I've gained weight. 8:14 like, I feel like I've gained weight. And I'm like, well, that's probably some 8:16 And I'm like, well, that's probably some 8:16 And I'm like, well, that's probably some water weight because it's been a short 8:17 water weight because it's been a short 8:17 water weight because it's been a short amount of time. Or they'll say, oh, in 8:19 amount of time. Or they'll say, oh, in 8:19 amount of time. Or they'll say, oh, in the six months I've been on HRT and, you 8:21 the six months I've been on HRT and, you 8:21 the six months I've been on HRT and, you know, I gained weight. The HRT caused me 8:23 know, I gained weight. The HRT caused me 8:23 know, I gained weight. The HRT caused me to gain weight. 8:24 to gain weight. 8:24 to gain weight. >> And, you know, that's where we don't 8:26 >> And, you know, that's where we don't 8:26 >> And, you know, that's where we don't want to, you know, put the blame all on 8:28 want to, you know, put the blame all on 8:28 want to, you know, put the blame all on the estradile. When you're starting with 8:30 the estradile. When you're starting with 8:30 the estradile. When you're starting with a patient, you're considering HRT, you 8:32 a patient, you're considering HRT, you 8:32 a patient, you're considering HRT, you want to look at their metabolic status 8:34 want to look at their metabolic status 8:34 want to look at their metabolic status in the moment. 8:35 in the moment. 8:35 in the moment. >> Got Yeah. And granted, that's why pretty 8:38 >> Got Yeah. And granted, that's why pretty 8:38 >> Got Yeah. And granted, that's why pretty much in every patient, we go through 8:40 much in every patient, we go through 8:40 much in every patient, we go through some metabolic and inflammatory markers 8:42 some metabolic and inflammatory markers 8:42 some metabolic and inflammatory markers to see their status before starting HRT 8:45 to see their status before starting HRT 8:45 to see their status before starting HRT and then track that over time because 8:47 and then track that over time because 8:47 and then track that over time because menopause in general, like you've said 8:49 menopause in general, like you've said 8:49 menopause in general, like you've said before, is the biggest, you know, risk 8:51 before, is the biggest, you know, risk 8:51 before, is the biggest, you know, risk factor for age related disease. It's 8:53 factor for age related disease. It's 8:54 factor for age related disease. It's just going into menopause on its own 8:55 just going into menopause on its own 8:55 just going into menopause on its own without anything. Uh, you throw life and 8:58 without anything. Uh, you throw life and 8:58 without anything. Uh, you throw life and stress and sleep and all those things 8:59 stress and sleep and all those things 8:59 stress and sleep and all those things into it. So the woman's uh you know when 9:02 into it. So the woman's uh you know when 9:02 into it. So the woman's uh you know when she's in her mid-4s going into her early 9:05 she's in her mid-4s going into her early 9:05 she's in her mid-4s going into her early 50s, where is her metabolic status as 9:08 50s, where is her metabolic status as 9:08 50s, where is her metabolic status as she's getting ready to start HRT, the 9:10 she's getting ready to start HRT, the 9:10 she's getting ready to start HRT, the more metabolically insensitive she is, 9:13 more metabolically insensitive she is, 9:13 more metabolically insensitive she is, meaning the more insulin resistant she 9:15 meaning the more insulin resistant she 9:15 meaning the more insulin resistant she is, uh the more potentially dangerous 9:17 is, uh the more potentially dangerous 9:17 is, uh the more potentially dangerous that is or the more susceptible she 9:20 that is or the more susceptible she 9:20 that is or the more susceptible she could be to gaining weight. 9:21 could be to gaining weight. 9:21 could be to gaining weight. >> Yeah. And that's why when it's not just 9:23 >> Yeah. And that's why when it's not just 9:23 >> Yeah. And that's why when it's not just like here, take this estrogen and 9:24 like here, take this estrogen and 9:24 like here, take this estrogen and progesterone and go on your way. We'll 9:26 progesterone and go on your way. We'll 9:26 progesterone and go on your way. We'll see you in a few years or something. No, 9:27 see you in a few years or something. No, 9:27 see you in a few years or something. No, it's like, okay, we're going to use the 9:29 it's like, okay, we're going to use the 9:29 it's like, okay, we're going to use the hormones as a tool. What else are we 9:31 hormones as a tool. What else are we 9:31 hormones as a tool. What else are we going to work on metabolically to help 9:32 going to work on metabolically to help 9:32 going to work on metabolically to help that person so they don't continue 9:34 that person so they don't continue 9:34 that person so they don't continue gaining weight over the next six months, 9:36 gaining weight over the next six months, 9:36 gaining weight over the next six months, >> year, six years? You know, that's what 9:38 >> year, six years? You know, that's what 9:38 >> year, six years? You know, that's what we're that's where we're looking at is 9:40 we're that's where we're looking at is 9:40 we're that's where we're looking at is looking at it the big picture as opposed 9:41 looking at it the big picture as opposed 9:41 looking at it the big picture as opposed to someone which I've had people say, 9:44 to someone which I've had people say, 9:44 to someone which I've had people say, "Oh, I stopped the hormones because I 9:45 "Oh, I stopped the hormones because I 9:45 "Oh, I stopped the hormones because I thought it made me gain weight." Like, 9:46 thought it made me gain weight." Like, 9:46 thought it made me gain weight." Like, nope. You know, the we want to use it as 9:49 nope. You know, the we want to use it as 9:49 nope. You know, the we want to use it as a tool or maybe switch you to a 9:51 a tool or maybe switch you to a 9:51 a tool or maybe switch you to a different form that might be more gentle 9:52 different form that might be more gentle 9:52 different form that might be more gentle for you. There's so many different ways 9:54 for you. There's so many different ways 9:54 for you. There's so many different ways to do HRT. It's really trying to craft 9:56 to do HRT. It's really trying to craft 9:56 to do HRT. It's really trying to craft it for that particular individual, for 9:58 it for that particular individual, for 9:58 it for that particular individual, for their goals and their body. 10:00 their goals and their body. 10:00 their goals and their body. >> Yeah. And that honestly at the end of 10:01 >> Yeah. And that honestly at the end of 10:01 >> Yeah. And that honestly at the end of the day that that we're not even talking 10:03 the day that that we're not even talking 10:03 the day that that we're not even talking right now about the form of HRT, whether 10:06 right now about the form of HRT, whether 10:06 right now about the form of HRT, whether you know estrogen, progesterone, those 10:08 you know estrogen, progesterone, those 10:08 you know estrogen, progesterone, those do make a difference. Uh you know, but 10:10 do make a difference. Uh you know, but 10:10 do make a difference. Uh you know, but this one is just kind of a big picture 10:12 this one is just kind of a big picture 10:12 this one is just kind of a big picture view because there's no mechanism in the 10:14 view because there's no mechanism in the 10:14 view because there's no mechanism in the body that tells uh that estrogen tells 10:17 body that tells uh that estrogen tells 10:17 body that tells uh that estrogen tells the body or estradile tells the body to 10:19 the body or estradile tells the body to 10:19 the body or estradile tells the body to store fat 10:20 store fat 10:20 store fat >> directly. 10:21 >> directly. 10:21 >> directly. >> Yeah. Directly. uh it just 10:22 >> Yeah. Directly. uh it just 10:22 >> Yeah. Directly. uh it just >> there's some indirect little pathways, 10:25 >> there's some indirect little pathways, 10:25 >> there's some indirect little pathways, but 10:25 but 10:25 but >> and that's what most women are 10:26 >> and that's what most women are 10:26 >> and that's what most women are experiencing, you know, as you're 10:28 experiencing, you know, as you're 10:28 experiencing, you know, as you're starting HRT, it's going to, you know, 10:30 starting HRT, it's going to, you know, 10:30 starting HRT, it's going to, you know, your body has to have a chance to 10:32 your body has to have a chance to 10:32 your body has to have a chance to acclimate to some of those uh to that 10:34 acclimate to some of those uh to that 10:34 acclimate to some of those uh to that new addition of those hormones. 10:36 new addition of those hormones. 10:36 new addition of those hormones. >> So, I'd love to know any of you 10:37 >> So, I'd love to know any of you 10:37 >> So, I'd love to know any of you listeners or viewers your story. So, if 10:40 listeners or viewers your story. So, if 10:40 listeners or viewers your story. So, if you have any um if you feel comfortable, 10:42 you have any um if you feel comfortable, 10:42 you have any um if you feel comfortable, you can write it on you can write it on 10:44 you can write it on you can write it on 10:44 you can write it on you can write it on the comments below your story about 10:45 the comments below your story about 10:46 the comments below your story about weight gain or weight loss with 10:47 weight gain or weight loss with 10:47 weight gain or weight loss with Estradial. or if you don't, you know, if 10:49 Estradial. or if you don't, you know, if 10:49 Estradial. or if you don't, you know, if you want to be more anonymous, you can 10:51 you want to be more anonymous, you can 10:51 you want to be more anonymous, you can go on our website, 10:51 go on our website, 10:51 go on our website, progressyouhealth.com, and click on ask 10:53 progressyouhealth.com, and click on ask 10:53 progressyouhealth.com, and click on ask the doctor and you can write your story 10:55 the doctor and you can write your story 10:55 the doctor and you can write your story in there because I love to hear from all 10:57 in there because I love to hear from all 10:57 in there because I love to hear from all of you. 10:57 of you. 10:57 of you. >> Yeah. Now, granted, this is a really 10:59 >> Yeah. Now, granted, this is a really 10:59 >> Yeah. Now, granted, this is a really complicated topic and there's a lot more 11:02 complicated topic and there's a lot more 11:02 complicated topic and there's a lot more we could say about it. We just want to 11:03 we could say about it. We just want to 11:03 we could say about it. We just want to give an overview for now. Um, so yeah, 11:05 give an overview for now. Um, so yeah, 11:06 give an overview for now. Um, so yeah, like she says, write down in the 11:07 like she says, write down in the 11:07 like she says, write down in the comments below and uh we'll uh see you 11:09 comments below and uh we'll uh see you 11:09 comments below and uh we'll uh see you on the next on the next episode. So, 11:11 on the next on the next episode. So, 11:11 on the next on the next episode. So, until next time, I'm Dr. Mackey 11:12 until next time, I'm Dr. Mackey 11:12 until next time, I'm Dr. Mackey >> and I'm Dr. Valerie. 11:13 >> and I'm Dr. Valerie. 11:13 >> and I'm Dr. Valerie. >> Take care. Bye-bye.
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