Full Transcript Podcast Introduction and Regenerative Medicine Overview 0:00 Hey there, welcome to the Recharged Biomedical Podcast. 0:03 I'm Dr. 0:03 Edward Park, and if you're curious about regenerative medicine, you've come to the right place. 0:08 We're diving into the latest breakthroughs in telomerase activation, stem cell exosomes, and all the cutting edge science that's shaping the future of 0:15 healing and longevity. 0:16 Let's get started. 0:18 Hi everybody, this is Dr. 0:19 Ed Park, the host of the Recharged Biomedical Podcast, and today I thought we would just improvise a lecture of frequently asked questions. 0:28 I just finished an eight week improv comedy course, which was great. 0:31 I won't burden you with my attempts at humor. 0:34 If it comes in, I will apologize in advance. 0:37 The first question I get a lot is going to be frequently asked questions is what is an exosome?
What Exosomes Are and How They Signal Healing 0:43 So exosomes are how cells talk to each other. 0:47 That's all plants and animals. 0:49 And interestingly, although they observed it for nearly 100 years, they thought it was poop until about 20 years ago. 0:56 They said, what if we strain the broth that these cells are growing in and melt the capsules of these invisible 100 nanometer spheres? 1:05 and they found that there was purpose there. 1:07 There were notes, and these notes, they tend to be microRNA. 1:11 So microRNA is something that, bear with me, is a little complicated, but basically in your cells, some cells throughout your body, 1:20 They're kind of in an adult resting phase. 1:23 So if you block the blockers of their de-differentiation, then they can de-differentiate. 1:29 So a lot of these microRNAs block the programs that keep you mature and normal, and they make those local cells act young and robust and regenerate like 1:38 they're in utero. 1:39 And that can look like regeneration of joints, nerves, blood vessels. 1:44 So it could have some really potent eutaining effects, if you will. 1:47 Another question you might ask, well, how is that different from stem cells? 1:51 Well, stem cells are attracted to areas of inflammation. 1:55 So if you get a paper cut or get stabbed, your body will be inflamed and it'll send exosomes from the stem cells. 2:04 But really, the stem cells, whether you get them from yourself or from another person, their actions are mediated by exosomes. 2:11 So the exosomes are the songs of healing. 2:14 Your stem cell will go there, release exosomes, and it'll teach the local knee cartilage or the finger laceration to heal faster. 2:24 So the local stem cells will act primitive and immature and grow. 2:30 All right. 2:31 So the question is, well, what's the practical difference? 2:36 Well, the practical difference is that stem cells are usually more costly. 2:40 I just did a phone call with a consultant who has a machine, but very few people have a machine to test cell viability. 2:50 So when you thaw out a vial of someone's stem cells, you don't know how good the product is or how viable or even if they're alive.
Exosomes vs Stem Cells 2:58 So it tends to be quite a bit more expensive. 3:01 In chondrodistinction, exosomes are not alive. 3:04 They don't have mitochondria cell machinery, pathways. 3:08 They're very tiny and they're literally invisible. 3:11 So when I melt a vial, it should be clear. 3:13 If it's cloudy, I know something is above 200 nanometers, which is the limit of light detection. 3:20 So the reason we don't use stem cells is because, number one, they will be rejected by your immune system because they have self-identifying antigens. 3:29 And the youngest and most potent ones are from a newborn placenta, which is what we use, single donor placenta. 3:36 So why not just get the effective message across? 3:40 It's kind of like you can play a song by the Rolling Stones or you can hire the remaining Rolling Stones to come to you. 3:46 It's more expensive. 3:47 They might not even play as well as they used to. 3:50 So you might as well just get the songs from a newborn baby placenta because you're healing in my case, you know, almost 59. My punch that's packed inside 4:01 the X-Somes is weaker. 4:02 All right, so a question might be, well, what about PRP? 4:07 Well, PRP is even further up the chain. 4:09 So PRP, they take out your blood, and we did a great episode with Dr. 4:13 Gelber on the Recharged by My Podcast explaining this. 4:16 It causes inflammation, which brings in your stem cells, your 59-year-old stem cells, and then it releases your 59-year-old exosomes. 4:24 So it can work. 4:25 I just had a recent patient who had a terrible intertrochanteric band or the side of the thigh pain as she did PRP and it made it worse for four weeks 4:36 and now it's getting better after an exosome shot. 4:38 So it's a Faustian bargain when you trigger intentional inflammation, it usually goes well, it can go poorly as well. 4:45 And the other question you might ask, well, what about steroids? 4:48 Well, steroids, when I took the class seven, eight years ago to train in ultrasound guided injections, the Marine Corps doctor said, 4:55 you got to be careful with tennis elbow. 4:57 As we know, some cases of steroid ejection will cause atrophy and rupture. 5:02 Why is that? 5:04 Well, because steroids cause a decreased inflammation, yes, but they also cause atrophy of these organs, including, but not limited to the ligaments,
PRP and Steroid Injections Compared 5:14 tendons, and the cartilage. 5:16 So this is well known, even though they're paid for, they are not FDA approved, nor is there evidence showing that they will help. 5:23 Steroids have their place in acute inflammatory conditions like gout, pseudo-gout, rheumatoid arthritis. 5:29 But again, it's a Faustian bargain because in the long run, it will lead to more disc problems in the back, more knee cartilage erosion, 5:38 so not recommended. 5:39 But in the old days, that's all we had before the orthobiologic revolution. 5:43 And so that's the problem. 5:45 You might ask, well, how do I know this is going to work? 5:48 Well, you really don't. 5:49 As in anything in life, it's an asymmetric risk. 5:52 I would say certain areas are more likely to work. 5:55 The older you are, the more damaged it is, the less likely. 5:59 But you have to define your end point. 6:00 I mean, an improvement in function, a decrease in pain. 6:04 And even radiographic improvements are all great, but you have to be realistic. 6:08 Like you can't refurbish a house in a day. 6:11 So I always tell people if it gets better, then consider repeating it in two or three months. 6:17 We can still see effects up to two or three months. 6:20 And if it doesn't get better or gets worse, which I rarely ever see, then just bail and forget the exosomes. 6:28 You might ask how much does it cost? 6:29 Well, it depends really on how many vials I need to thaw out for you, because they're very expensive. 6:35 That is the main part of the procedure. 6:38 I, unlike a lot of other doctors, don't charge more for more areas. 6:42 Although I think if you're doing more than five areas, it's too much homework for the body. 6:47 And so probably limited to that. 6:48 So there's one milliliter and five milliliter products, and there's one triple concentrated, five triple concentrated. 6:55 It's basically a multiplier of how many vials I need to bring to treat you. 7:01 So just FYI, that could look like 500 to like 6,000 and up. 7:05 But if you're talking about stem cells, you're in the ballpark of five to 10,000 usually. 7:11 If you're talking about these mu cells, which they allege through good research out of Japan, mu cells are de-differentiated stem cells that can become tissue. 7:23 And that was the misunderstanding that we held for years. 7:26 In fact, in my first book, I thought that mesenchymal stem cells went to the sites and then grafted and differentiated into muscle tissue because we know
Treatment Expectations, Cost, and Mu Cells 7:37 they can do that in vitro or in the glass in the petri dish and indeed it's one of the very interesting things I learned at the Hong Kong International 7:48 Stem Cell Research Conference. 7:51 They have booths and vendors that have cookbook recipes on how to de-differentiate any cell and then make it into any cell type. 7:59 It's really quite remarkable. 8:01 Indeed, you can find my blog about curing diabetes. 8:05 They have a brilliant doctor out of Peking University who cured type 1 diabetes by de-differentiating your cell and doing the steps to make it a pancreatic 8:15 islet cell and implant it in your rectus sheath. 8:18 And I think actually in Germany, they're commercializing this. 8:21 But it's basically at the time last year, they were seven for seven for cures, which is astounding. 8:27 So yeah, cell differentiation, mu cells, they charge 30 to 40,000, I think. 8:32 I think it's way too much. 8:34 And the three or four people I've talked to didn't have dramatically good results at all. 8:38 So I would say that's probably not ready for prime time. 8:41 A question I have, well, how do I learn more? 8:44 You should purchase my book, which is also audio book, Existone Songs of Healing. 8:49 You can go on my website and I go over the different treatment areas. 8:53 If you're a doctor, you can take my online training course and the full tuition of which is credited back as purchase credit for exosomes. 9:00 Yeah. 9:01 And then the Recharge Bible Medical podcast and my YouTube channel, DRPARK. 9:05 You can like and subscribe and we have a lot of content there. 9:08 So another question is, well, my friend did this. 9:12 My other doctor recommended that. 9:14 What's the deal? 9:15 Why are there so many brands? 9:17 Well, I'll tell you this, it's not hard to make an exosome. 9:20 All you gotta do is have a stem cell and then you filter out what's in its broth every couple days. 9:27 The main thing, the reason why they're so expensive is the quality control, right? 9:31 Because you're only as good as your worst batch. 9:34 A patient told me two years ago that in Japan, there were some fatalities from a contaminated batch and now the notion of exosomes is quite looked down 9:43 upon there. 9:43 So that can happen. 9:44 And so for my practice for the last seven, eight years, it's really only been one brand. 9:50 And I would say estimate there's been 30 brands, half of them have gone out of business or pivoted. 9:57 I would say that quality control is a function of your supporting cast. 10:01 So the brand I use has six PhDs, 40 employees, multiple redundant quality control. 10:07 They have eight giant cryogenic freezers. 10:10 They keep track of their lots and the quality in perpetuity. 10:14 So if there's ever a problem, which is hard to imagine there would be because of the sterility conditions, but they definitely are on top of it.
Learning More and Brand Quality Control 10:21 The conversation I just got off with from the stem cell advisor, He said he visited a guy who I think I know he didn't want to mention his name. 10:30 And sometimes these labs are in kitchenettes and strip malls next to check cashing places and they are far from sterile. 10:38 And it's really just a money grab. 10:40 So really for me, you know, even if one patient gets hurt. 10:44 That's one too many. 10:45 Unfortunately, if you find out a lot of the successful brands in the market are actually white label, which means they have no control over the manufacturer, 10:53 what they're doing. 10:53 And so they have to trust the manufacturer and they just are marketing firms. 11:00 So anyway, without naming names or alienating people, that's my impression. 11:04 It's better to have somebody that has scale and high levels of quality control. 11:11 All right. 11:11 So you might ask, well, how do I get a treatment? 11:14 Why don't you start by getting a consultation? 11:16 So do a little due diligence around reading the book, listening to the book, watching some videos. 11:24 And then you can always go to our website www.rechargebiomedical.com slash contact hyphen us. 11:31 And there you can book a complimentary 20 minute zoom console where we really. 11:37 Go through all your medical history and how eczems may help you. 11:41 And it's a super efficient thing. 11:43 It's very low pressure and it's often quite enjoyable to get to know each other and, and find out how we can help if at all. 11:52 Last week, I released a video of my mom who is 88 and she drives several hundred miles a week back and forth to the casino where she loves her slots. 12:03 And I think that her lifestyle as an independent 88-year-old woman is really a testament to how well she's doing. 12:11 Does she have medical problems? 12:12 Sure. 12:12 She has some heart arrhythmia. 12:15 It used to be high blood pressure, now it's low after 40 exosome shots. 12:20 But so far she's very independent, very sharp, and very full of life. 12:24 So it's something that I think can help. 12:28 in a way, like a panacea. 12:31 And I think more is more. 12:33 And so if you'd like to address that in terms of health and wellbeing, get in touch with me as well. 12:38 Because the only patients that I've seen, other than mom and two others that we talked about last week, they really have had transformations in their vascular system, 12:48 their hormones, resumption of a premature menopause out of menopause, erectile dysfunction, hair repigmentation, I think people really, 12:59 if you tell them, hey, give me this amount of money and in a year you'll look and function eight years younger, they do it. 13:06 But people are. 13:08 quite complacent by nature. 13:10 And so they tend to think, well, I'm feeling good.
How to Get a Consultation and Patient Examples 13:12 Why should I spend more money? 13:14 So they don't see the big picture. 13:15 And the people with the deep pockets, you know, some of them also don't want to take that point because they're like, well, 13:21 I should save my money and buy more real estate. 13:23 But in the grand scheme of things, I have a very dear friend who is in the struggle with stage four cancer. 13:32 And I think that nothing really is more important than your health. 13:36 And you realize that all too late. 13:38 So anyway, this was my improvised sort of lecture on exosomes. 13:43 I know it may come off as a bit salesy. 13:46 It was not my intent. 13:47 I am a believer. 13:48 I think that exosomes can help a lot. 13:50 They've helped me. 13:51 They've helped hundreds of my patients in thousands of encounters. 13:55 And so if you're at all curious about this, plenty of content on DARK65 YouTube. 14:01 Join my sub stack at d-r-e-d-p-a-r-k, and we set out private emails. 14:06 And we also have monthly Ask Anything webinars. 14:09 Yeah, I think that's kind of what I wanted to say. 14:12 Oh, finally, are they safe? 14:14 Yes, I think they're very safe. 14:15 I've only had one serious complication, which could have happened with steroids or hyaluronic acid that was a knee infection. 14:21 you know, out of probably seven, 800 knees. 14:23 I don't, maybe I'm not sure, but I think they're very safe. 14:27 They're very anti-inflammatory. 14:28 And again, they can't be rejected because there's no self-adjective. 14:31 So for all intents and purposes, you start healing for a time like a newborn baby. 14:37 So what could be better than that? 14:39 All right, well, that's about it. 14:41 If you have any other questions that weren't addressed, I'm sure you could contact me at rechargebiomedical.com slash contact hyphen us and there's a form 14:51 for either booking an appointment or for asking me a question. 14:55 And we usually get back to pretty quickly. 14:57 I'm Dr. 14:57 Ed Park. 14:58 I'll see you in the next episode of the Retired Biomedical Podcast. 15:02 I'll be attending a conference next week and I hope to find other great guests. 15:06 If you haven't been watching, you've been missing out. 15:08 We've done psychedelic assisted drug therapy. 15:12 We've done EMF. 15:14 poisoning and control mitigation. 15:16 We've done mold infections. 15:18 We've done treatment of autism. 15:20 A lot of the sort of fringe areas that these experts have brought to you through our Recharged Biomedical Podcast, I think it's a great service. 15:29 And unfortunately, as most patients eventually come to realize, the doctors don't really have the bandwidth or the interest to dig a deep dive into your case,
Safety, Ethics, and Closing Thoughts 15:38 always adding prescriptions and counting the days to retirement. 15:43 So you have to be the quarterback of your own healthcare. 15:46 And part of that is just learning some of these fringe things and keeping them in your pocket. 15:50 I wanted to fly out to Hawaii. 15:52 My friend is not contacting me, but. 15:55 You know, there's a couple of really interesting fringe cancer treatments. 15:58 So as with everything, the advanced guard, the extremes, that's where the progress is. 16:04 And there's a lot of resistance to those treatments. 16:07 I hope that exosomes are more mainstream. 16:09 I know the fact that we interviewed Dr. 16:12 Gelber and he's a believer as an orthopedic surgeon. 16:15 I know one of my patients. 16:17 Her ex-husband is orthopedic surgeon. 16:19 They say they talk about exosomes all the time. 16:21 Indeed, after going to two exosome international conferences, one stem cell conference, there is no disagreement that this is not a fringe startup out 16:30 of Silicon Valley or whatever, central Linux. 16:33 This is basic science and there's no reason why it wouldn't work. 16:37 When I go to these conferences, they're very hostile towards me because they're like, well, what, what right do you have to do this? 16:44 And that's very legitimate. 16:45 I, again, I make it a point not to overcharge people like these mu cells. 16:51 And I make it a point to treat multiple areas as an added value. 16:56 And I never over promise and we always disclose fully it's not FDA approved or standard of care. 17:03 So we do what we can to be ethical. 17:06 But again, no one will argue that it doesn't work. 17:09 They will argue that the quality control isn't there, the scientific proof isn't there, except in animals. 17:14 But again, I'm a believer and I think people do have the right to try what they can to mitigate and to improve their health. 17:21 So, all right. 17:24 I think that's enough. 17:25 I'll see you in the next episode of the Recharge Biomedical Podcast. 17:28 And thank you for liking and subscribing. 17:31 I've spent years studying how cells age and why we age and about cell communication. 17:38 Exosomes are now changing the way we understand cell communication and providing an opportunity for us to reverse some of these problems. 17:45 Pick up a copy of Exosomes, Songs of Healing, and in simple English, I explain how this is working and why this is the future of medicine. 17:54 go to www.rechargebiomedical.com, subscribe to my sub stack at d-r-e-d-p-a-r-k, and watch my YouTube channel at drpark65. 18:07 Thanks so much. 18:08 Thanks for tuning into the Recharge Biomedical Podcast. 18:11 If today's episode got you thinking, you'll love my book, Exosomes, Songs of Healing. 18:16 It's packed with cool analogies, full color illustrations, and all the science you'll need to understand how exosomes are changing the game in aging and 18:25 regenerative medicine. 18:26 You can grab it in paperback, ebook, or audiobook, whatever works for you. 18:30 Now head over to www.rechargebiomechanical.com to check it out. 18:36 And don't forget to like and subscribe so you never miss another episode. 18:41 See you next time.
Comments