Ferroptosis – Could This Be The Root Cause Of Your Symptoms?

Bob Miller, CTN

It’s a pleasure to be here. It’s good to see you again. We go back many, many years.

Dr. Kelly Halderman

As we do this. It’s just a pleasure. And I know that you work so hard and so fast and so quickly, you and your team that I kind of fell off the educational that education that you put out and the content and you’ve come so far. And so today we’re going to talk about a topic that I’m really admittedly know nothing about. And that’s exciting for me because a lot of the guests, most of the guests, we talk about things and I’m pretty well versed in. But this concept of ferroptosis, am I saying that right? We’re going to get into that and how it’s relevant to chronic disease. And I know you biopsy a lot of very sick people, but I do think it’s relevant in thyroid health. I’m sure people like me. When I had Lyme, I got Hashimoto’s. And so really this topic is relevant for again thyroid health. But I’m certain start us off by telling the audience about yourself, about your practice and how, how you’re, how you’re managing to find all these new neat pathways and things like you do.

Bob Miller, CTN

Absolutely. Well, I will make this very short because people want to hear a subject, and I’m a traditional natural path from Trinity’s School of Natural Health. Been doing this for about 25 years and maybe around 17 or 18 years ago got very fascinated by genetics. And it was love at first sight. As I often say, that started looking at something as simple as homocysteine and then learning that there’s genes related to that. And at the time we had 23 and me where you could download their data and we started out by making a simple little spreadsheet. I mean, it wasn’t too simple, but we made a spreadsheet and we used that to analyze the data. And when you think of genetics, you often think of things like 23 me, where you learn your ancestry, or you think of seeing a professional geneticist that looks for your for your disease. States. What we’re looking at is quite different. We’re just looking at what we call function, how the body’s functioning. And we’ll get into that a little bit as we go along. And then I started studying Lyme disease that I was very fortunate. 

I on two occasions won the research award and I lad’s conference we’ve been at speaking around the world on the genetics as it relates to Lyme disease. Then we started getting involved in more toxicity or mycotoxins and we’re just about ready to launch a new study on that, where we’re going to look at the IG and the IG markers in various mold patients and then look at their genetics to see if there’s any patterns. So probably by maybe mid to late summer, we’ll have that we’ll have that study out. So then I started my own software that we couldn’t use a spreadsheet. So I started an online software program that measures genomics. We’ll look at that later. And now we have hundreds of doctors out using that. We have online certification courses. But the bottom line is it’s all about contribution to humanity, making sure that in this toxic world we’re living in, we have the ability to get rid of these things. One of my favorite jokes when talking to people is I say I was born in 1954 and back then Earth was a different planet. We didn’t have all the environmental factors that we have today. And that is taking a terrible toll on people, which is going to relate to what we’re going to speak about today. And that is a ferroptosis.

Dr. Kelly Halderman

Okay, great. And I will say that I have taken the training course. I have used the software. I am a believer. And I he personally changed my life and my health of knowing about my age. Fijians really. Bob I have a lot of gratitude toward you for your research. I am one of those people that have been touched personally by your work. So again, just very grateful for you to be here today and now to get into this topic. So let us in. I’ll give you the floor.

Bob Miller, CTN

All right. Well, we’re going to do a screen share here.

Dr. Kelly Halderman

Okay.

Bob Miller, CTN

And let’s see, lecture on the right screen. You’re seeing the screen, okay.

Dr. Kelly Halderman

Yes, I am.

Bob Miller, CTN

Okey dokey. So the topic is Ferroptosis and many people are saying what? Because it is a new form of non programed cell death. And of course you always want to mention this is education, informational purposes. We’re not giving any medical advice here, telling people how to treat disease. Here’s a little graphic we had made some time ago. And you can see it’s the two scuba divers underwater playing a 3D chess game. And that’s why we say Ferroptosis, a 3D chess game played underwater. And the environmental and genetic factors that impact it. Now, the main topic we’re going to be talking about is ion. It’s interesting, Dr. Kelly, that you brought up the HIV gene because that is one of the key players in what’s happening here. But first, we’re going to state the obvious. We need iron. Two, it’s a mineral that the body needs for growth and development that helps maintain your healthy blood. It’s a central element for almost all living organisms your body uses to make hemoglobin. It’s stored in the body as ferritin in your body. You need some iron to make some hormones so clearly needed. It’s not bad unless it goes off into something called ferroptosis. And even interesting as we get into that, we’ll find that there are times that even this ferroptosis can be beneficial. But for most of our discussion today, we’re going to be discussing how it can really create havoc for us. So here’s a definition and we say Ferroptosis when iron goes bad, here’s key words. 

It involves oxidative damage to the cell membranes leading to cell death. It’s iron dependent and it’s distinct from what we think of as apoptosis. The normal death of the cells. If plays an important role in the development of various inflammation related diseases, it’s involved in the progression of inflammation such as autism, which is surprising, which of course is going through the roof acute injury, acute kidney injury, rheumatoid arthritis, substance, sepsis and many of the neurodegenerative diseases. Now, I’m going to draw here, if I can, let me get the drawing tool and you can see why. Now we’re going to be causing we’re calling this the 3D chess game. So there’s an enzyme called Knox in ad oxidase. And as you know, Dr. Kelly, I’ve been talking about this for years. This is an enzyme this I like to say it’s our friend, unless it isn’t. And what I mean by that is that when we’re faced with a pathogen, what an amazing immune system we have, it says, Oh, there’s somebody here that doesn’t belong here. Let me grab some oxygen and something called Ned and make something called superoxide, which is a nasty, free, radical. Now, when we’re faced with some kind of pathogen or virus or bacteria, we want this to happen. If this didn’t happen, we die of infection. So it’s our friend. So I often say, though, unless it isn’t, because there’s now so many environmental factors and when we do, our case study will show that there’s so many factors that will upregulate the Knox enzyme. And it was many years ago, I’m sure you remember this, Dr. Kelly, we talked about the ATP Steel that that ATP, which is needed for so many factors, is used by this to make this superoxide then an enzyme called sudi makes hydrogen peroxide and then iron comes along and makes what’s called a hydroxyl radical endotracheal. You remember years ago when we were presenting, we talked about the Fenton reaction, nothing, nothing new here. So if you over absorb iron or you don’t clear your hydrogen peroxide, Fenton reaction goes on. So we’ve been talking about that for years. Here’s the new part. When we don’t handle our fats properly, our polyunsaturated fatty acids through another enzyme called a lox that we’ll talk about that can get upregulated, it will show in the church how they can get upregulated. We make a very toxic substance. 

Phospholipid I do peroxide and this is where we do membrane damage and we create ferroptosis. Now, what makes this complex is that the body is amazing and has ways to calm this down. There’s an enzyme called giga found peroxidase number for the combs this down co Q10 which we all know about, combs it out, but it’s got to be the right form of co Q10 and something called tetrahedra Brompton B H for all of those on that down. Now there’s many environmental factors that will stimulate, including things like Mycotoxins, Lyme disease, COVID virus. You can have genetic factors where this is Upregulate, you can have genetic factors where you don’t clear hydrogen peroxide. And as you mentioned, you can over absorb iron. You could have multiple genetic factors where you don’t handle your fats properly. You can have many genetic factors where you don’t make enough to live without peroxidase work. You can even have genetic factors on coke, you tend and genetic factors on page four. So there’s a heck of a lot that can go wrong here. Dr. Kelly If any one of these is not doing its job properly, we are going to be experiencing Ferroptosis. Would you agree this is a fairly complex, fairly complex.

Dr. Kelly Halderman

But Bob, you have an amazing gift to really simplify it. I would say, in terms of making it practical and relevant.

Bob Miller, CTN

Well, thank you. Now, here’s what can happen. And I think this is just the tip of the iceberg. This can be a fact. You went on to say this is de facto, but if I factor in Alzheimer’s and Parkinson’s, brain tumors, heart disease, heart failure, osteoporosis, pancreatic issues, kidney issues, kidney injury, gastrointestinal inflammatory, bowel disease could affect the liver. Chronic liver disease, respiratory lung cancer and things like age related macular degeneration and glaucoma. And I think this is relatively new. I mean, the scientists have only been studying this for a short period of time. That’s why we haven’t heard much about it. But there’s now evidence, even with stroke, that all of these can be created by Ferroptosis as being a factor. Now, I just want to pull this slide up very quickly. This is a slide we’ve been using for years, but it just shows how we can get extra hydrogen peroxide. Yes, that’s the same thing that you put on a cut. So when we create superoxide, there’s an enzyme called Saudi that makes the hydrogen peroxide. Then we need catalase, glutathione, peroxidase and throw a dioxin to turn it into water or water and oxygen. If we don’t, here comes iron hydroxyl radicals. And we’ve been again, we’ve had this in the software talking about this for probably the last ten years, but now we’re taking it to the next step that if we don’t use the fats properly, we create this ferroptosis. Now, I’m going to show you just a couple of slides. And again, this is all relatively new things. So what’s the conclusion? And by the way, if anybody just types those words into the search engine, this study will come up. We just take a couple of keywords here. Our study systematically elucidated the intricate correlation between ferroptosis and autism spectrum disorder. So this may be one of the things that’s causing the rise in autism. 

Clearly not the only thing. But in some cases, it’s a factor. And here they’re talking about an autism group showed a significant increase in the percentage of cells undergoing cell death. The autism group also had lower levels of ptosis, therefore suggesting the role of other cell death pathways. So their bottom line is they believe that Ferroptosis plays a role in autism disorder. Now, this is quite fascinating. This is a relatively recent study. Is ferroptosis a key component in the process leading to multi-organ damage in COVID 19. So the study says there’s the possibility that SARS-CoV-2 may trigger Ferroptosis in the cells of multiple organs, thus contributing to multi-organ damage. Because, as we know, some people and this was only published in October of 21, so as we know, you know, some people get COVID and they’re like, well, that was no big deal. And others are like, yeah, I didn’t feel so good for a little while. Others are incredibly sick on ventilators and dying, so why not disparity? And there’s clearly more than just ferroptosis. We don’t want to make that claim, but I would supposition that in some of the people that are really struggling more so than others, they may have been set up genetically and environmentally that this process was already going on. And then the proverbial bucket is full. Something else comes along, fills the bucket, and turns it over the edge. That makes sense.

Dr. Kelly Halderman

Yeah, definitely that makes sense. And I think that is a quandary of why, you know, we have risk factors. Obviously, as we went through the pandemic, we knew that being overweight and other chronic illnesses would contribute to morbidity mortality. But I’ve never heard of this. But it makes complete sense. And maybe those people who we are just confused. I was having dinner with a friend and he was telling me about his friend who was perfectly healthy in his early forties and was in a coma for for several days and ended up having, you know, coming out but is now in kidney dialysis. And so this could be that missing link. It would be really interesting to run genetics.

Bob Miller, CTN

Yeah, that’s not the answer for everybody, but I think.

Dr. Kelly Halderman

It’s the clue. Yeah.

Bob Miller, CTN

Factor. And here’s another study. We’re not going to read the whole thing, the biological processes ferroptosis involved in the pathology of COVID 19 and their conclusion that ferroptosis was involved in COVID 19 disease. And the function of core in these are it’s another gene. They become a new research a new research aspect of this disease. So clearly, this could be why some people are struggling. Now, another subject that we could spend a whole hour on now, days on actually would be massive activation. So this has now become a huge problem. You know, when you talk to doctors who’ve been practice ing for for 20 years or more, you ask them how much mass l’activation did you see 20 years ago? And it’s like maybe one or two a year. And now it’s like maybe it’s 30 to 40% of the people who come in the door. So it’s in case anybody doesn’t know, mast cells are white blood cells. And again, they’re are friends unless they’re not meaning that if they’re overactive, they can create all kinds of problems. So this is referring to prostatitis, but I think of it, I’ve seen other literature that shows that this ferroptosis starts the process of making the mast cells be overactive and the mast cells activate ferroptosis this cycle, this osteoporotic bone loss from excess iron accumulation is driven by that. An ATP drug today has triggered ferroptosis in osteoblasts. And again, this was just February of this year. I mean, this is brand new research. 

This is something that’s just coming to the fore. And for everyone in functional medicine, I think they need to start looking at this ferroptosis in its role in epilepsy. So we won’t read the whole thing. But there’s, there’s the abstract where they’re talking about they believe this is playing a role in epilepsy, neurally radical diseases, intracerebral hemorrhage, strokes, epilepsy, neurogenic diseases, traumatic brain injury and brain cancer may also be related. Again, relatively new January of 21. Here’s an article ferroptosis in COVID 19 related injury, a peripheral nerve injury. So if anybody’s watching this, if they want to read it, maybe they can pause or just put these words into a search engine and you can read the study. We don’t have time today to look at each of these. But the interesting homocysteine, we know it’s not it’s not good. And there’s a book out there that talks about how the higher the homocysteine, the sooner you die from all causes. And again, Dr. Kelly, we were talking about homocysteine years ago as it relates to methylation. Interestingly, in addition to all the other stuff that it does, it it induces ferroptosis by helping break down glutathione. Peroxidase four Here’s an article on lung diseases inflammatory arthritis, a promising future for arthritis. If we can get this under control. Organ fibrosis as a ferroptosis involved in an intestinal epithelial cell, death in ulcerative colitis and again inflammatory bowel disease is increasing dramatically among young people. This used to be for the, you know, the older crowd. 

And now teenagers and younger are getting inflammatory bowel disease. Now, we’re going to slow it down here just a little bit, and I’m going to walk you through the map. So we created a map that shows the potential for Ferroptosis. And I do believe we’re the first ones that have done this, that have actually looked at all of the genes that are involved. So we’re going to start up here and let me get my drawing tool there, and we’re going to start with an enzyme called Tina Fey tumor necrosis factor alpha. And perhaps people have heard of that. And again, I’m going to use this same phrase again, it’s our friend, unless it isn’t. So when we’re faced even with a cancer cell or other pathogens, Tina Fey says, Oh, something’s wrong here. I need to make inflammation and it will stimulate. And if Kappa B, then it will stimulate the Knox enzyme, and then that will stimulate something called Interleukin six, and that begins a cascade of inflammation. Now, interestingly, mycotoxins virus lipopolysaccharide rides clostridia glyphosate and Lyme disease will all stimulate this. However, we’ve talked earlier, there’s a gene called HSV that’s involved with the ovaries, with the absorption of iron. There are genetic mutations that will cause this to be upregulated very prominent in the English and the Irish and the Ashkenazi Jews. 

Now what’s interesting is particularly among the the Irish, many people might remember that the reason people came to America from Ireland was the potato famines. Interestingly, the women who had the over absorption of iron during a famine were the only ones healthy enough to have babies. So consequently, by natural selection, people of English and Irish descent often have this gene. Now there’s a disease called hemochromatosis, where when you get the mutation from both parents, it’s very serious and it can be life threatening. And people have to do phlebotomy on a regular basis to get rid of the iron. However, even a single copy can be mild and it won’t be fair. It won’t be hemochromatosis, but it will cause you to absorb more iron. And then I’m going to talk later. There’s a couple of other snips or gene steps, mutations that can cause disruption of the iron. So then we stimulate the NF Kappab, then we stimulate Knox, and that’s what we spoke about. Now, interestingly, there’s a whole bunch of other things that can go on here. Electromagnetic fields. You know, we all love our cell phones. Dr. Kelly We have them with us every day. We’re sending text messages, we’re checking our email. We love them, but we may find over time that if we’ve got mutations in the CAC in a1c genes or just too much exposure, look what it does. It stimulates the Knox enzyme, then dopamine. We need dopamine to feel good about ourselves. However, there’s genetic mutations where you don’t clear dopamine out of the body or turn it into norepinephrine. Excess dopamine stimulates the Knox enzyme. Another process is when we get things like sulfites, which is in red wine and even some foods like garlic, there’s an enzyme called zoox that needs to turn it into sulfates. 

So we do a process called salvation, phase to salvation. And then there’s actually enzymes that transport molybdenum, which is the cofactor for salts. If something goes wrong here, NOx enzyme gets upregulated. And then finally what a miracle the body is. We there’s enzymes called him oxygen. He’s here to take what’s called him that comes from glycine in something called seasonal C away from our Krebs cycle and we go through these eight steps here to make the heme. Then there’s enzymes called him oxygenate and I don’t have it on this chart, but it actually makes something called Biliverdin and Bilirubin that interestingly calms this down. I know a lot of people are saying bilirubin. Isn’t that what goes high when people have liver problems or when a baby’s born? Absolutely. But in small amounts, it’s right up there with. Good. Now, for those of you who really want to dig into this, you know, I just did a 45 seconds. If you go on YouTube and search Carnahan for Dr. Joe Carnahan and he meets me. We talk for about 90 minutes on this subject where we really dig into this in depth and talk about all the things that can happen in through here. Now, there’s also enzymes called keep one and Nerve two and Nerve two controls the turning on of all year and oxidant, but it also will impact something called G six PD that makes that any BPH that we spoke about earlier and we need any EPA for this heme oxygenate enzyme people of southern Italian, Native American, African, South American oftentimes have mutations on g six PD that they don’t make enough of this and then they’re in trouble. And there’s an enzyme called p0r that places this electron. And on here you can have a problem there as well. So you can see there’s so many things, Dr. Kelly, that can go wrong here that do not allow you to hold this back. So then when you live in a multi health or you get Lyme disease or you get a virus or you get too much glyphosate in you, this whole thing takes off. And if anyone already has this upregulated, they’re in a boatload of trouble. That makes sense.

Dr. Kelly Halderman

Absolutely. And I did some research about a year ago on Knox, just it was researching for a talk. And I just wanted to give a little brief information. And I found it very interesting that the pharmaceutical industry is extremely interested in creating drugs that shut off. KNOX. I mean that, right? I mean, that that doesn’t surprise us, right? As practitioners whatsoever. But I’m sure you’re going to tell us about some of the products, too, or let us the listeners know that there are things we can do about this. And Bob is going to go through a case study and show us that there’s nutrients. And like you said, like some of our own things that we produce in the body, so.

Bob Miller, CTN

Mm. Yeah, absolutely. We, I formulated about two years ago a product called up in ADP to protect that actually has things in it that slow down the Knox enzyme. So interestingly things like spiraling you know AC DC lycopene from tomato they all slow down the Knox enzyme and I’m going to be reformulating that in the in the near future. Okay so then we get our superoxide and interestingly, this is a really important genetic mutation and cool one because NQ Oh one inhibits or breaks down superoxide. All right then the, the journey continues. We make the hydrogen peroxide, as I showed you earlier, we need catalase and we can have mutations on catalase. There’s a whole new subject called thrive dioxin that I am absolutely fascinated by. No one’s talking about throw it out. So and we need to because this takes care of inflammation inside the cell and clears hydrogen peroxide. Now, clinical observation only, I’m finding that there’s two pathological evidence based snips on NRT and too. And the people who have both of these homozygous or the ones that are in dire straits stopped doctor hopping from one person to another, can’t seem to get any help because they can’t take care of the inflammation inside the cell. So this is a big one that we’ve got to spend some time on. Sure. 

So Chlorophyll is the master antioxidant and there’s a glutathione peroxidase, one that uses glutathione. And it will also clear the hydrogen peroxide homocysteine that stimulates the hydrogen peroxide. Now, we could do a the whole lecture just on the value and you know, in the holistic field is becoming quite popular to talk about the benefits of taking gluten. So as we know, gluten comes from cysteine glycine and glutamate and it these enzymes assemble it. Okay, and this is GC age. Then as we know the found is a master antioxidant has a spare electron when it does its job it becomes oxidized, meaning it lost it. We then need an enzyme called GSR to take this oxidized glutathione and recharge it. Well, guess what? We can have genetic mutations on GSR that we don’t do a good job replacing it or recycling it. So as the thyroid becomes popular, there’s a lot of good around products out there. So someone thinks I’m flamed an equal failed. Sometimes it works beautifully, sometimes it backfires because if you don’t recycle, you’re going to fail. When you take glue to fail, this seems like such an oxymoron, but if you take all the fail and you don’t recycle it and you just get down to here, this actually creates inflammation. I mean, isn’t that an oxymoron that under the wrong conditions, taking you to fail can make you more inflamed?

Dr. Kelly Halderman

Yeah, that’s really interesting. And when I was in clinical practice, I would use the doctors data to see the different levels of their risk reduced versus oxidized. Because it’s so important, because again, like you said, it will, it’ll work against you. And so with that, with the GSR that’s in your software, all these then yourself are okay. And then okay, great.

Bob Miller, CTN

All right then we need glutathione oxidase for to calm down this ferroptosis. So here you can now get to the point where you’re going to see where the ferroptosis occurs and that is where the hydroxyl radicals combines with your fats to make the ferroptosis. Now remember I said bh4 is one of the cool factors. One of the cool factors, one of the factors that reduces ferroptosis and we will get into them all today. But all these enzymes are responsible for making bh4. So if you’ve got genetic issues that you don’t make enough for and you’ve got ferroptosis going on, you’re not holding it back. Now, additionally, there’s nitric oxide inside the body and that’s what gas the dilates, the blood vessels. There’s two nitric oxide enzymes. One is called Enos or Nash two, and one is called Nash three. So Nash three is what makes the nitric oxide, the dilates, the blood vessels won a Nobel Prize in 1998. However, there’s a Nash two that makes a lot of nitric oxide to kill pathogens. This will probably be the fourth or fifth time I’m going to say this a good thing. Unless it isn’t. So if this guy is upregulated or it’s overstimulated by histamine, it runs too fast, runs out of bh4, which is the cofactor, then hang on to your head rather than making nitric oxide, it makes superoxide. So I’m sure there’s a lot of people that have probably tried this. 

They see that arginine turns into nitric oxide, so they think, Hey, I’m going to take arginine and get more nitric oxide, and all they do is get cold sores and feel worse, right? Because they’ve run out of bh4. So we got to make sure before you start taking arginine that you’ve got to look for end in ADP. H So, so what we’re finding is that many of the people that are struggling with their mast cells are activated. They’re stimulating ion us. They have cold hands and feet. And then this Enos suppresses their Enos and then this can lead to two blood clots and the iron acts can lead to what’s called platelet activation. And then when we get the mast cells and there’s a genetic mutation called kit that can cause that to be upregulated, we make histamine. There’s all kinds of genetic mutations. We don’t clear our histamine, and therefore the histamine stimulates the in us. And then finally, when this TFA is upregulated by iron or some mica toxin, it stimulates an enzyme called play to the pulls arachidonic acid out of the cell membrane. I’m doing a lot of tests called a major. Can we just prick your finger and it measures your your good fats in the arachidonic acid? I am stunned by how many people have arachidonic acid through the roof off the charts. And that can happen because there’s enzymes called fatty acid saturations that take your omega threes and turn them into useful things that knocks down inflammation. So I’m sure there’s probably somebody listening to this who says, you know, I learned all about the benefits of fish oils. I started taking them and I felt worse than most people hit me.

Dr. Kelly Halderman

That’s B So you just explain to me what’s company.

Bob Miller, CTN

Yes, but we need to look at your fads. But I don’t have it on this chart. But any deep age is also the cofactor. So if NOx is upregulated.

Dr. Kelly Halderman

And it’s stealing all that energy, right? That it doesn’t hit. Wow, that’s cool.

Bob Miller, CTN

Then these are not even a benefit. And they’re worse by taking fish oils and people are confused. I hear all this good stuff about fish oils. Why do I feel worse? Well, if your ATP age is gone or these fads enzymes are gone, and many of the people we see are struggling, they might have what’s called homozygous meaning for both mother and father on every one of the fat snips. That seems to be a common theme in people that are struggling. We need to hold back the plate, too, and then if we don’t, we get the arachidonic acid that combines with the hydroxyl radical to make your ferroptosis. And then finally, Dr. Kelly, everybody knows about the benefits of coconut in, you know, it helps provide energy inside the cell. You know, the no news there but most coke you turn your purchase if you look very closely it says ubiquity now and there’s another version of Coke. You turn cold, you become normal, not very common. And the reason they sell ubiquity is because we, your body, will turn it into the form that it needs sometimes. So if you’ve got mutations on NQ O one or mutations in all of these guys right here or you’re not getting any delivered because you’re not making it or stealing it, we don’t get that precious form of ubiquity. And guess what? Ubiquity all does. It calms down ferroptosis.

Dr. Kelly Halderman

Just to stay right here for a second, Bob. I see the problems because of what you’ve taught me about the age for like this is this is very hard to just magically like have enough beads for. There’s a lot that goes into it. You’re, you’re uncoupled. You have a lot of the histamine, the mast cells. There’s a lot of work there. I also see the glut of science of just not taking it willy nilly, not taking because it can backfire. You don’t have enough needles. You’re not going to recycle. It’s like I feel like our most hopeful way to see if everyone’s looking at the the graphic here of kind of calming that people or age is is maybe to really get your genetics test done and Bob’s going to go through that it’s the gold standard and to make sure you’re taking that right coke you Coke you tend to my would that be I mean are you a fan then of coke you ten.

Bob Miller, CTN

Oh absolutely the right coke you ten ubiquitous all and then another interesting source of B four is just royal jelly. Okay, that is what you know, that’s what they give the bees. The worker bee gets the regular honey, the royal the the queen bee gets the royal jelly. It’s a naturally occurring source of b h for a product. The Beach four is complex and we’re tweaking a formula to see if we can boost this. But if you can, you know, stop this process, slow this down, if you can make sure the iron’s under control, you’ve got enough glutathione, you’ve got enough coke, you ten, enough bh4, and you don’t have nasal uncoupling and there are nutrients. We actually formulate a product called Z knows that sole purpose is to slow down the iron aisles enzyme so interesting some people they’ve got gain of function on us like a function on in us. They get cool hands and feet, they take l-arginine and they feel worse. Now, interestingly, if somebody finds this whole subject very fascinating, again, go to YouTube. Carnahan’s the RNA, any JM Enos I.R.A. s and I discovered we spent, I think about an hour and 40 minutes with Dr. Jill, believe it or not, just talking about this and, and you can have what’s called gain of function on the anus, where the anus is trigger happy. So if that anus is trigger happy, anything that comes along, they would normally stimulate it to be helpful. It’s overactive. That’s why we often say that everything you really need to learn you learned Goldilocks to three bears. Not too much, not too little, not too hot, not too cold. So without anus, we probably die of infection. But when I ask is upregulated, it depletes our bh4. It stops, it slows down our circulation, sets us up for blood clots, steals the bh4 that we need to calm down the ferroptosis and bh4 is also needed to make serotonin and dopamine. Now, Dr. Kelly, how rampant is depression in the country right now?

Dr. Kelly Halderman

Oh, my goodness. It’s very sad. Very sad.

Bob Miller, CTN

And it is very sad. So one of my four famous words are for people who are depressed is it’s not your fault if you don’t have enough b h for it’s like having a brain spanking new car without any gas. So if your beach four is depleted, you’re not going to make serotonin. Now, everything I’ve told you up to this point is based upon, you know, peer reviewed literature. I’m just going to go off the tree a little bit, give about Miller opinion. So this in three bucks will get you a cup of coffee. But I think the body’s pretty intelligent and it will prioritize the use of bh4. So I have a sneaking suspicion is just hypothesis that if the body’s inflamed with this ferroptosis it’ll say Sorry, I got to keep you from burning up if you’re not happy. Too bad, but we’ve got to take care of this first. So and I’ve run that by a couple of physicians and they all say that makes sense, that the body would prioritize what needed to be done, particularly when when that ferroptosis can be so complex. So I know we just, you know, did a two day lecture and 25.

Dr. Kelly Halderman

Excellent. Well done. Well done.

Bob Miller, CTN

Now, just so people understand now, this would be particularly for practitioners. If you’re a practitioner listening to this and you’re intrigued, you know, we’re not I’m not going to go through each of these, but each of these little green boxes is supplements that we made that can actually support that function. So like we said, protect to hold this down cytochrome six to calm this down h marxist just to help here. Cribbs heme assist to support here. So we actually made products like that design us to calm this down. Now obviously you don’t take all of these, but you use genetics to see where the problem is. And then you put these in a targeted form. So each of these is a separate supplement. Like, for example, we got mast cells, there’s a AMC stabilizer, there’s two side products, there’s glutathione icon education. That’s not good I that supports blue without these ways to protect for me. MF calm down dopamine support salvation and you know doctors have to learn where you need to jump in. So this is not a hub. What do you do for Ferroptosis? It’s like, I don’t know, it’s individualized. So you could see 30 people, right? And different solutions. That’s why it is a little bit complex. Now we’re going to do a quick case study, very sad case. 24 year old female chronic inflammatory demyelinating polyneuropathy rheumatoid arthritis, Lyme mast cells, ehlers-danlos hearts and Crohn’s. Oh my goodness. So what I’m going to do is a actually now bring in my software. Now this is the functional genomic analysis software. And you know, Dr. Kelly, in the past, we just had reports, we now have interactive maps.

Dr. Kelly Halderman

Okay.

Bob Miller, CTN

So you can actually map this thing out and then you can see what’s going on. So, for example, this young lady. Oh, you know what? Let me just do one other thing first. I’m getting ahead of myself here. This is her. A magic want. The omega threes should be 8 to 12%. She’s coming in at 4.18. We make a 6 to 3 ratio. That should be 3 to 5 was 8.5. But hold on to your hat. Arachidonic acid, that should be 2.5 to 11. The chart only goes up to 32. She was 42.9.

Dr. Kelly Halderman

Oh, my goodness.

Bob Miller, CTN

Yeah.

Dr. Kelly Halderman

Wow.

Bob Miller, CTN

And then glyphosate, which is Roundup, should be around 0.4 somewhere around there. Again, off the chart at 3.6.

Dr. Kelly Halderman

Oh, that’s sad.

Bob Miller, CTN

Yeah, it’s very sad. Now let’s look at why this may have happened. Firstly, the upon one is the enzyme that clears glyphosate and this one has a pathological downregulation so she’s got a mutation there then is whole pathway here. So you see a cool filling and software. When I click on Eleanor, it actually brings up over on the right the genetic mutations. And these are now all the pathological evidence based ones. Oh yeah. We have someone with their masters in now in genetics who’s helping with the research. So we’re not just listing all the snips, we’re looking the ones that are pathological. So you can see here that she’s going to have a hard time and then look what happens when we get to the heme oxygen she’s homozygous. Both parents get a mutation mutation on all of them. So not holding back the information then the IL six is likely upregulated. Oh, by the way, there’s another Dr. Jill video on IL six or somebody wants to watch that Carnahan Hannah l6. So then she’s stimulating the NOx. I remember we talked earlier about sulfates not turning into sulfates. Look at this. Both parents gave a mutation on the sulfate to something likely sensitive to MF, not turning dopamine into inactive metabolites, all of that stimulating NOx. Now we didn’t talk about the sirtuins yet, but the sirtuins are interesting enzymes and they are being studied intently for their impact on the body’s health. One in particular called Sirt, one hold back nf Kappa B Knox supports OD two and also supports Enos.

Dr. Kelly Halderman

Is that the resveratrol linked.

Bob Miller, CTN

And intermittent fasting could bless her heart. Both parents gave her a mutation. No. Wow. And if you look at this pie chart here, only 1.5% of the people in the software have it. Wow. And if we do a a bell curve, you can see that 76% of the people out of 52,000 don’t have any mutations at all. She’s down here with 1.7% of the population in the software, which is really sick. People. So bless her heart, cert one’s not doing its job. Then she’s going to make hydrogen peroxide catalase double mutation that she doesn’t cure it clear that you have enough catalase to clear glue without peroxide peroxidase one you can see a mutation over here.

Dr. Kelly Halderman

Bob, did she have any early graying of her hair? Did you notice?

Bob Miller, CTN

No. What was interesting and again, this is just a excellent question. This is just a Bob Miller clinical observation. When people have hydrogen peroxide high and they don’t have this going on, they really prematurely appears as though one is hydrogen peroxide very quickly combined with iron. They don’t. Great. But again, that’s just a clinical observation from somebody who just looks at these all day. The three a dioxin. You can see here that these are the evidence based pathological her three thrive dioxins not working so she’s overproducing this not clearing through the redox and not clearing through catalase, not clearing through lithium peroxide is one. Then look at the iron. This is a evidence based transfer factor that only happens in point 5% of the population ferritin, light, chain transfer and factor. Oh, so there’s no evidence base there, but a couple others that are research. So More than likely she’s got hydroxyl radicals going on and we already saw that the arachidonic acid is through the freaking roof. Okay. 

And when we look at her fans enzymes, you can see not too bad on the fat enzymes, but you see some people that have mutations on all of those. But I believe what’s happening is the environmental factors are stimulating the arachidonic acid to come out of the body. And then when we look at the age for you can see that this MTA GFR e 1298 and DHEA fa can impede the body’s ability to make beach four then on the highest to on the nost two side double mutation on the gain of function on not to move. So this is going to be running quickly depleting B for that. You’re not making enough up. She’s very depressed obviously. Yeah. Yeah. So then that B Beach four is not being made adequately being chewed up by nasty two. These two are probably competing and not able to cut back that ferroptosis then clearly when you’re exposed to all these things, you’re making a lot of histamine and these are the genes that are related to clearing histamine. This is a pathological one. Histamine Methyltransferase clears histamine Sirt1 controls the MTA and MLB, the control system. And so the ability to clear histamine is compromised.

Dr. Kelly Halderman

Then you’ve got that come right. Didn’t she have comp where she wasn’t clearing for her comp was right in estrogen. Yeah. So that’s yeah.

Bob Miller, CTN

Yeah. And then the sirt1, as we said, controls now three so clearly cold hands and feet and poor circulation which has its own set of challenges. So then not too bad on the CO Q10, but a little weakness on nerve to the controls and one so likely not too much of a problem here for some folks this is the main issue. Personally, I’m a train wreck in here. That’s why I take 400 milligrams of you bacon all every day. So her weakness, though, is that she’s creating all this the beach for is not being made being used by us. So she’s likely just having all this inflammation inside the body that she can’t she can’t function. So that’s how you can determine what’s happening and then make a custom made. Oh, finally, the GSC enzyme is what assembles the ingredients to make sure that they are struggling and then also struggling recycling fluid. Now male spoke this is unprecedented that we’re able to take a peek at that these kind of things. So just a quick commercial we’re not going to, you know, be big on this. But if you’re a practitioner, somebody, this is not for the public. So practitioners only, this is the software we use functional genomic analysis. We’ve been at it for, oh, over 12 years and I think we’re up to around 3.5 million of investments into the software. The new Drake Research Institute is who does the research? The software is our cloud based software that organizes, interprets the snips. This is just the genetic test. Your functional genomics, we have our own genetic test and then the supplements we use our functional genomic nutrition. And interestingly, we’re not going to get into that today, but we even have the ability to custom make something that is individualized for the person. Again, if you’re a practitioner, we have online training, an online certification course first couple of modules are free to see if it’s for you. It’s not for the faint of heart. It’s for those who are serious. 

That was the DNA test. And then just another plug here for the software. If you’re a practitioner, you can do a 30 day free trial. And so if you take the the course and get the free trial, you can learn how to use it. Now, one of the comments we often hear is this is incredible, Bob, but it’s a little complex, which we are working on what are called executive reports. And I’m hoping they’ll be ready by maybe early mid-summer where there will be logic in there. That’ll actually logic I put in there that just brings attention to what things they should look at. So for the person who’s overwhelmed. So stay tuned for that. So we’ve got reports for the patient and health professionals, the pyramid pie charts, bell curves that you saw, pathway maps, dynamic messages that the jump in based upon that that individual guidance on supplements you can private label them if you want custom make you know for some people they’ll they’ll look at a supplement that’s excellent and they’ll say oh I can’t take fill in the blank right. Oh so, so then you can make a custom that’s actually manufactured for them that takes those things out or combines things together. There’s just a couple of things. There’s the recycling of the glue, the found barracks, and I tried superoxide dismutase, but we have a quite a list of supplements. And if anyone is watching this who’s not a practitioner and says, I’d like to take a look at that, you can give us a call. Tree of Life is our is our company and townhall.com is the website 7177332003. The genetic test measures 250,000 snips totally confidential. You don’t have to worry that it’s going to go anywhere. And also, we’re not geneticists. We’re just looking at function. So as I like to tell everybody, we’re not going to drop any bombs on you. We’re not going to tell you that looks like you’re getting a serious disease. We’re just looking at how you might be making quality free radicals, not nothing. Oxidants, detox pathways. So I like to tell everybody we have no bad news. The only bad news we could ever give you would be like, I’m sorry, I don’t see anything to help you with, but everything we find we could compensate for.

Dr. Kelly Halderman

Right? And knowledge is power and specific knowledge about your genetics. Biochemistry can give you the tools. You know, we see so many people who have been from doctor, doctor, doctor, because they’re applying protocols to that person, not principles. And this the way that Bob goes about this in really getting to the bottom in that personalized way and then digging in that way, I mean, you could see from that case study we talk about in the book, the thyroid debacle, Dr. Eric and I about cellular hypothyroidism and how the root cause there’s not just one usually it’s a lot of different things that are happening to cause the cellular stress. We just had that case report looking at all of those factors that were playing into this particular woman’s cellular stress, inflammation, those pathways. And I mean, that’s very powerful. And I’m sure, you know, your software keeps advancing. And I will say that it’s not as steep of a learning curve if you’re a practitioner as you’d think. Bob makes it very simple and clickable and, you know, suggest that, okay, if this is awesome, you might want to go see Blood Labs. So there’s a lot of nuances that are brought in to really help you. So, Bob, I felt that it just keeps getting easier and easier to use your software and to help people. So I think that’s it I think that you did a phenomenal job of a brand new topic that is obviously playing a role based on not your opinion, Bob, but the studies that you showed us and how it’s involved autism, rheumatoid arthritis and cancer, it’s that graphic really blew my mind. And so I’m just very grateful for your time, for your expertize. I’m so glad that you told everyone where they can find you. If you want to have Bob look over your genetics and help you out with that with the structure function, I know that you helped me many years ago where I let you do that a word. You sat me down with my genetic report and told me to do this, this and that, and it really, really helped my health. So I thank you so much for your time today. I really appreciate it.

Bob Miller, CTN

It was a lot of fun. Thank you for the opportunity.

Dr. Kelly Halderman

You’re welcome. Take care. Thank you for joining me. Dr. Kelly Halderman on the Thyroid series for the DrTalks podcast. I hope you found this episode informative and engaging, and if you did make sure to subscribe to our podcast so you don’t miss out on future launches. Don’t forget to follow DrTalks on social media platforms, including Tik Tok, LinkedIn, Twitter and Instagram to stay informed about our latest updates and events. For more information on thyroid conditions and other health topics, visit our blog at DrTalks.com/blog, where you’ll find a wealth of in-depth articles and resources to help you manage your health effectively. If you want to learn more about the latest medical breakthroughs, how to prevent, treat and reverse chronic conditions, sign up for one of our free summit at DrTalks.com/calendar. You’ll find that DrTalks Summits feature some of the leading health experts in the world, and they’re a great way to stay up to date on the latest research and protocols. Thanks again for tuning in. We look forward to bringing you more valuable insights in our next episode. We’ll see you next time on the DrTalks podcast.