Full Transcript Longevity and immune aging overview 0:00 At the age of 20. 0:01 Our immune system has been formally 0:05 developed, and so we see a gradual decline 0:08 in immune function from the age of 20 to 50. 0:11 There's a drop and at 60, there's a significant drop. 0:15 Just because you're getting older and just because of how the body's 0:17 is wearing down. 0:19 People and patients in their 40s and 50s need to be thinking about this now. 0:24 In practitioners, especially mid-life crisis, 0:27 we need to look at how we support the immune system. 0:29 And no wonder 0:30 we see such a rise in chronic disease and cancer rates like never before. 0:34 That's the key to this whole thing, is how to get ahead of it. 0:37 So for the longevity discussion, we need to get this early. 0:40 We need to have this be part of the discussion. 0:42 And then we should hopefully see healthier, better aging 0:46 just instead of having people on feeding tubes 0:48 till they're 100 like we're talking quality of life, right? 0:50 What if aging isn't about slowing down but leveling up? 0:53 I'm Doctor Isaac Jones. 0:54 This is the Longevity Leaders podcast. 0:57 All right. 0:57 Welcome everyone. 0:58 This is the Longevity Leaders podcast. 1:00 I'm your host doctor Rudy Mueller. 1:02 And today we have with us Doctor Eric Zelensky. 1:05 Doctor Z and I go way back I mean, 8 to 10 years ago, I would say. 1:09 Yeah, he was a mentor for me and moving forward on a, a summit, 1:15 a successful summit. 1:15 And so it's great to reconnect with you. 1:17 And it's been a while has been, but it's wonderful. 1:20 I'd love to hear a little bit more about what you've been up to.
Podcast introduction and guest background 1:23 We were just talking about how you've got seven kids now, so that's 1:27 something that you've been up to. 1:28 But then professionally, I want to hear a little more about what you've been doing. 1:31 A lot of pickleball, a lot of babies. 1:33 I it's been fun, doc, I am going back to my roots. 1:36 You know, I cut my teeth in this industry 15 years ago 1:39 as a public health researcher. 1:41 And then I just got launched into this online world writing books and like you, 1:45 hosting summits and just being able to reach a lot of people 1:47 through content in education. 1:50 And there's always has been this call for me to get back to the research, 1:53 because that's I'm that guy that that enjoys reading PubMed research got. 1:57 Into. That. 1:57 And it's something that how God made me. 2:00 And so a friend of mine, Reggie Black, owns a company called BW labs, 2:04 and they sell a wonderful product called Beta Glucan. 2:07 He's like like, I want to do a research study 2:08 on this thing and what we've ended up doing. 2:11 I'm one of the lead researchers with Christie, a demo, 2:14 wonderful, wonderful integrative medicine. 2:18 PhD researcher from the University of Maryland. 2:20 And this is going to be a study that we're going to be evaluating 2:23 how beta glucan affects immunological and biological age. 2:27 And people taking a product. 2:29 So 60 people taking a product for 90 days, very few, as you know, 2:33 there's very few companies actually put their money where their mouth is, so 2:37 to speak, and say, look, 2:37 we're going to actually test our product on real people and see what it does. 2:41 So we partnered with Tru Diagnostics. 2:43 They're going through the immune age evaluation. 2:45 And we're just going to get a ton of data. 2:47 And right now we're sitting on some data. 2:49 And we can't wait to publish this paper in the next two months. Awesome. 2:51 So where are you with that clinical study? 2:53 Yeah, it's it's completed and we are now in the epidemiological stage right now. 2:57 The epidemiological epidemiologists are now looking at the data. 3:01 We're writing the intro, the conclusion. 3:04 And we're looking at how we can I mean, we're sitting on seriously 3:07 10 to 15 papers just from this one study because when you yeah, 3:11 we have over 80 biomarkers that we've evaluated on 60 different people. 3:15 So this one study is just going to give me a lot of work for the next few years 3:19 for sure. 3:19 Partnering with people like Doctor Jill Carnahan, doctor Bob Roundtree, 3:23 all these folks are gotten behind BW labs to educate on beta glucan. 3:28 So it's a wonderful team 3:30 that Reggie and the team have created as a medical advisory board.
Beta glucan research study and clinical setup 3:34 And I'm one of the researchers. So awesome. 3:36 Oh that's wonderful. Yeah. 3:37 And so with that, I mean, what really got you interested in this company? 3:41 What was the one thing from beta glucan or that you're looking at or researching? 3:46 I mean, was it something where you started out 3:47 looking at the hallmarks of aging and you see immuno senescence 3:51 as being one of the hallmarks that needs to be directed or addressed 3:54 and some sort of solution found for or like what really drove you 3:59 to finding the beta glucan as being an option for you. 4:03 It was a combination of things, quite frankly, is this is evolution 4:06 that I've uncovered and becoming very skeptical of the supplement industry. 4:11 Sure. 4:14 And I don't 4:14 want to just target the industry as a whole, 4:18 but we've traded big pharma for a big supplement. 4:22 And a lot of the supplement companies sell trash. 4:25 They're selling petrochemical based products. 4:27 And what we find is the efficacy 4:30 and the clinical outcomes change from dose to dose, batch to batch. 4:34 And when you talk to practitioners 4:36 they're like, yeah, I used to use this, but then it didn't work anymore. 4:38 Like why do you think that was the bottom line? 4:40 Purity standards and what BW labs has. 4:44 And there's only a handful of companies that I know that do this. 4:47 They actually have a purification spec. 4:49 Every batch is tested and their purification spec is 85%. 4:53 So they're beta glucan. 4:54 And beta glucan, by the way, 4:55 is extracted from cell walls of baker's yeast in this particular case. 4:58 And they purify it. 5:00 And what's left over is just some minor fiber and residual content. 5:04 You can never get 100% pure of anything, right? 5:06 Just think about your gasoline. 5:07 You'll never get 100% pure, right? 5:10 So 85% pure is the highest purity standard of anything on the market. 5:14 They actually have exclusivity. 5:16 No other company can sell it. 5:18 And when I started thinking about this, like you literally won't accept 5:22 and sometimes they've run out of product 5:23 like you literally won't sell something that isn't under 85% and you're like, no. 5:27 And we're like, why? 5:28 And I was having this discussion with them because the research doesn't support 5:32 a lower grade, because the difference between 85% pure 5:35 and 75% pure, that 10% difference is an 800% efficacy change. 5:40 So meaning 5:40 this most products on full script, most beta glucan that you see on Amazon, 5:44 they're selling anywhere from 60 to 75% pure, which 5:49 just to point out that doesn't mean it's contaminated. 5:51 I'm not saying it's bad, I'm just saying potency. 5:54 You literally have to take eight times as much of the product 5:58 to get the same efficacy as one dose of a product 6:02 that sells 85% pure. And that's just open up my mind 6:04 to just this concept of what am I taking every day? 6:07 What type of vitamin C, what, what type of protein? 6:10 And I started looking down the trail. 6:11 How are these supplements made? What am I putting in my body? 6:14 And then knowing the founder, knowing the owner, 6:18 seeing it behind the scenes, I'm like, I'm sold. 6:21 I get this, and it's really reshaped how I view supplements as a whole. 6:26 And that's not to say beta glucan. 6:28 Well, I do think it's special, 6:29 but the fact that this product does exist, it is available.
Why product purity and consistency matter 6:33 It's now on full script. 6:34 Docs can get in on wholesale affiliates. 6:37 You know, 6:37 our old world affiliates can promote it if they want to, as well as on Amazon. 6:41 But to have this available and the clinical outcomes, 6:44 especially of the integrative oncologists that I know that are taking it, 6:47 people like Doctor Michael Carl Feld and others, Doctor Jonathan Stegall, 6:51 who's based out of, I mean, educated from Yale and Harvard from Atlanta. 6:54 I mean, we're talking people that are utilizing 7:00 natural therapies to help their cancer patients 7:03 just not only minimize the risk of any sort of therapies that they're taking, 7:06 but actually to help with the disease itself, with consistency. 7:11 And for any doc has, you know, we need consistency 7:15 in if you're buying another product from a supplier 7:18 that changes on a regular basis, whether the spec is 85%, one batch 70 7:24 or the other, that's a huge clinical outcome difference, 7:27 which makes your job more difficult as a doc, because you can't be scientific. 7:31 You cannot trust that what you're giving is going to give you the desired result 7:34 that you want, and that causes frustration to the patient. 7:37 So that's one reason why I wanted to sink my teeth 7:41 into this project, especially because they already have 26 7:44 studies on this product alone, like the product itself, not beta glucan. 7:48 I mean, there's literally over 7:49 100,000 studies on beta glucan, but the actual product is in the bottle. 7:52 There's over 26 studies as it is. 7:55 That's pretty profound. 7:57 So I know what to say. 7:59 Everyone wants to be part of a winning team. 8:00 I mean, you know what I mean? Like, 8:01 how many sports players ditch their team to go try to win the Super Bowl. 8:05 So that's kind of what I did. 8:06 I'm like, hey, this this team is winning right now. 8:09 How do I be part of it? Well, I love that. 8:11 I mean, one of the things that is often overlooked 8:13 as a practitioner in this space, when you first get into it, 8:16 is the quality of the things that you're recommending. 8:18 Course, you know, and when you go to these CME events, 8:21 they're not able to put the product name up there. 8:23 Right? It's a vitamin C, it's a EGCg. Right. 8:27 So we don't know. 8:28 And then you go home and you start orient 8:29 this with what's not having the desired effect. Right. 8:32 So when you're looking at beta glucan I love the fact that they are testing 8:36 every single batch. 8:37 I mean, when you have the purity now you have a reliable standard 8:40 and you're going to get reliable results and a more consistent, 8:44 dosing recommendation. Right. 8:45 That's going to. Work. Yeah, that's the bottom line. 8:47 Makes our jobs a lot easier as a practitioner. 8:49 100%. Yeah, absolutely. 8:51 Well that's wonderful. So with this product, 8:54 what you mentioned cancer. 8:56 So what conditions are beta glucan is particularly 9:00 gravy in your product with from better, better way. 9:03 Beta labs is the practitioner line but better way. 9:06 Health is the line for consumers. 9:08 They have a practitioner exclusive line. Okay. 9:10 So we have the labs the the product itself. 9:14 I mean what are you studying are particular conditions. 9:17 Is it just looking at longevity? Yes. 9:19 What are some of those areas where if I'm practitioner 9:22 listening to this or I'm if a client listens, 9:24 I should be looking into potentially beta glucan being a good thing. 9:27 That could help me and my immune system. 9:29 If you're a medical doctor, nurse practitioner, chiropractor or other health 9:33 expert that's stuck in a broken system, there's a better way. 9:37 The Freedom Webinar shows you a proven five step system 9:42 to build a seven figure virtual health practice, or how to modernize 9:47 your current brick and mortar practice without the burnout. 9:51 Learn to create high ticket programs, automated income, 9:54 residual revenue, and attract clients.
Immune resilience, modulation, and beta glucan 9:58 Ready to work with you? 10:00 Book your million dollar strategy session today by clicking the link 10:03 in the description. 10:10 So the current research on beta glucan is pretty widespread 10:13 when it comes to general health and wellness. 10:16 Immune system function, which I want to cover in a minute because, 10:20 when we look at immuno senescence is one of the key hallmarks of aging, 10:23 we cannot discount that. 10:25 I mean, it's more important than what we initially thought, quite frankly. 10:27 And it is now becoming your immune system's age, which we do know 10:31 you can measure your immune system age is more accurate 10:35 than your biological age to determine longevity, 10:37 and this is becoming more common knowledge for people. 10:39 And this is something that we're trying to do. We're actually improving it. 10:42 We're trying to show what actually happens to people 10:45 when you do trigger what's known as immune resilience, 10:48 which I hope I have a minute to talk about in just a second. 10:52 So while we're talking, we just describe immuno. 10:54 So now we'll go there, but we're talking. 10:56 But to answer your other question, 10:59 the the research 11:01 behind this product because of what it does to the immune system specifically. 11:05 And we'll explain that again. 11:06 But Crohn's autoimmunity, no contraindications 11:10 because it's an immune modulator. 11:12 Is that an immune stimulant? 11:14 Heart disease Alzheimer's 11:17 dementia chronic disease and chronic inflammation obviously. 11:21 Right. We go back to cancer, wound healing. 11:24 We were doing a study on athletes as well. 11:27 And mega marathon athlete can't release his name, 11:30 but he just did an unbelievable crazy, awesome feat. 11:32 We're going to be on this podcast soon. 11:34 Like the ability to recover from just extreme emotional and physical stress 11:40 all at the core of your immune system and how your immune system is functioning. 11:44 So the reality is that stock and I didn't learn this in school, which I 11:48 and this isn't to knock the education that we receive, 11:52 especially medical doctors, because very few medical doctors 11:55 know about this in terms of the training that they receive. 11:59 They have to get continuing Ed to get this. 12:01 But we're taught that innate immunity is this immune system that is wonderfully, 12:07 proficient at helping the body fight off 12:11 threats that come to it on a regular basis adaptive immunity, basic immune system 12:15 function that adapts, that responds better, faster, quicker, 12:18 but up until recently, the innate immune system 12:21 has been known as not having any sort of memory. 12:24 Well, that's completely incorrect. 12:26 And we know that's incorrect. 12:27 And now that this concept of okay, your body can be 12:31 your immune system can be trained, essentially trained immunity that your, 12:35 your innate immune system, which before never had a memory, 12:39 which is focusing on natural killer cells and macrophages and other biomarkers 12:43 that kill and destroy, that actually can be smarter, more adaptive in the future. 12:48 Yes, that's a huge finding. 12:51 And the fact that there is something that I'm coining as immune fatigue, 12:55 but the the research is kind of silent on a phrase on this. 13:00 And someone needs to call this we can stress out 13:04 and we could cause our immune system to essentially create damage to itself. 13:09 And that's the precursor of autoimmunity. 13:12 So immune tolerance is this concept where the immune function will actually 13:15 start to interact with pathogens in a way that prevents inflammation. 13:19 Immune resistance is this concept that your immune system is just ramped up. 13:23 It's seek destroy, seek, destroy. 13:25 If immune system isn't tempered by this immune tolerance, what happens is 13:29 your body will become immune fatigued and that will create damage. 13:34 And so when we're looking at immune 13:36 boosters, that is the complete opposite concept of what we need to do. 13:39 And I was never taught that. 13:41 And how many well-intentioned people right now are popping the Vitamin C's 13:44 and the zinc and all the things 13:45 before they go on an airplane or, oh, it's flu, cold, Covid season, 13:49 pop this pill, pop that, boost my immune system. 13:52 You don't want to ramp up something for the sake of ramping up a it's ineffective. 13:57 Would be it could cause damage to immune system in the future. 14:00 And so there's something in the middle of all of this. 14:02 It's called immune resilience. 14:04 And immune resilience is a term that's well found in in the literature. 14:08 It's about ten, 15 years old. 14:10 It's still haven't gotten into the medical Journal Chronicles 14:13 to get into the medical schools yet, but it's the body's ability 14:17 to adapt to respond, to not be fatigued 14:20 and to have the immune function stay where it needs to be. 14:24 It's essentially immune modulation. 14:26 So when you look at immune system, you want to modulate it. 14:29 You want to create homeostasis, you want to regulate it. 14:32 And at the core is immune resilience and immune resilience. 14:36 Now because of that because it brings homeostasis. 14:40 You want to take products that quote stimulate immune function. 14:43 You want to take products that temper it down. 14:45 You want to take products that bring balance to all of it. 14:48 That becomes quite confusing to people because they all interact with each other. 14:52 I mean, give me a protocol that if someone that's thinking in terms of this 14:56 and so most folks aren't thinking in terms of that, 14:59 and that's why we're positioning, because out of everything that we've seen, 15:03 the baker's yeast derived beta glucan, because of the specific 1316 15:08 linkage, has the ability to work in all of those areas. 15:12 So it will it will stimulate an immune resistance. 15:15 It will stimulate immune tolerance, 15:17 it will stimulate immune training, and it will stimulate immune resilience. 15:20 And then you look at like, wow, it's not like a wonder drug. 15:23 It's just this very unique concept or this very unique chemical structure 15:28 because it has a specific lock and key linkage 15:33 with that in one C or three receptors, which are known as the glucan receptors. 15:36 And so it's like the body was made to interact with glue cans. 15:41 People have heard and maybe we should have mentioned this earlier. 15:45 Mushrooms have beta glucan, oats a beta glucan. 15:47 I don't know if, you know, 15:48 if you saw the recent study mind blowing oat beta glucan on a human trial. 15:53 And animal studies this year have been shown to actually help 15:55 the body detoxify and reduce exposure of PFOA forever. 16:00 Chemicals. Really? It acts. 16:02 Yeah. It helps. 16:02 It's the only thing that has been tested right now that can cleanse the body 16:06 of forever chemicals. 16:08 And it's just the glucan concept, the glucan linkage, 16:11 the glucan ability as a fiber, but to stimulate the immune system. 16:15 So you have oat beta glucan, 16:17 which is good for detoxification of forever chemicals, heart health. 16:20 That's what made Cheerios famous, right? Heart health. 16:22 And then you have mushroom beta glucan, which is great. 16:25 You have algae beta glucan, but baker's yeast specifically 16:29 has that special 1316 linkage 16:32 that works in a way that no other chemical that we can see in the plant. 16:36 It does. 16:37 And when you purify it, you take away all the other question. 16:40 We always get, well, it's made from yeast. 16:42 Well, there's no proteins. You're purifying it. 16:44 You're extracting it from the cell wall has zero, zero ability that we know 16:50 to have an allergic reaction or contract anyone, 16:53 even with immunotherapy specifically, even with autoimmunity, 16:58 because it's an immune modulator, it helps regulate. 17:01 And when you regulate the T cells of CD4 and the CD8 17:04 T cells, that's one of the key biomarkers in 17:09 immuno resilience and gene expression. 17:11 So I'm going to go more into this into the talk that we have today. 17:15 And I really wish we had more time. 17:17 But the reality is is through a wonderful, complex system 17:21 of metabolic reprograming shifting the energy in the mitochondrial function 17:25 to do what the immune cells need to do. 17:29 And what we're seeing with the CD4 CD8 balance, 17:33 practitioners can actually measure immune resilience now 17:37 in a way that we didn't think was possible. 17:39 And immune resilience. And this was the key. 17:42 A study was published from the University of Utah in April, 17:46 167,000 people, 17:48 roughly, that people with stronger 17:52 and more adaptive immune resilience 17:55 have a biological age jump of 15 years. 17:59 It's that important. 18:00 And what we're trying to do and what I'm trying to do in my own life is just to see 18:05 how am I interacting with my immune system in a way that supports it 18:10 to do its job, not to burden it because it's already burdened. 18:14 And we can go in all day long about environmental toxins and
Study dosing, results, and closing remarks 18:18 and whatever it is that people are doing to themselves or earning themselves. 18:22 But as a practitioner, 18:24 immune system function might not be at the forefront of what you're trying to do. 18:27 But I guarantee you, if you're not looking at it, 18:30 it's not going to help your patient get to the level 18:32 that they need to get to in the the speed that you want them to get to. 18:35 And I've talked to enough practitioners and be like, yeah, you know, we'll 18:38 worry about immune function as a wellness strategy post. 18:42 You know, post recovery. 18:44 No, no it needs to be part of it. 18:45 It is core function of how your body reacts and responds 18:50 at the epigenetic at the mitochondrial level. 18:53 And so when you have your immune system taking up 18:55 so much of your metabolic energy, this is really 18:58 this is quite frankly mitochondrial dysfunction 101. 19:01 And we're not having that discussion. 19:04 And the end of the day, the thing that just blows my mind 19:06 is what makes people live longer, healthier lives. 19:09 And we're starting to see that natural decline of immuno senescence 19:12 doesn't affect centenarians like it does the average person. 19:16 And the key part of that is immune resilience. 19:19 And their immune systems just adapt better so they recover quicker, 19:23 or they don't have the manifestation of cancer like the average person does. 19:27 This changes everything and it changes everything. 19:30 How we see the immune system and how we see our health. 19:32 And also for me, it changes 19:34 the products that I take and just open up this can of worms of like, 19:38 I need to be smarter, I just shouldn't work harder now. 19:41 Beautiful. 19:41 I mean, when we look at pharmaceuticals, we're either 19:45 trying to ramp up immune system function, we're trying to dampen it. 19:48 And then that same thing as you mentioned earlier with the supplements. 19:50 So what I'm hearing 19:51 you say is almost like beta glucan is the conductor to the orchestra. 19:55 That is our immune system. I'm going to take that. 19:57 I'm going to write that down. And, you know, I like it. 19:59 That's a good one. 20:00 Yeah I mean that that's essentially what it is. 20:02 We're able to ramp up when we need to ramp up. 20:04 We're able to calm and we need to calm. 20:05 But it's overall creating this immune resilience that, 20:09 will allow people to have an immune system that functions 20:12 appropriately when it needs to and how it needs to. 20:15 Yeah. Yeah. That's beautiful. 20:17 And to prepare people for the future. Sure. 20:19 And here's the big thing that we all need to realize at the age of 20, 20:22 our immune system has been formally 20:26 developed. 20:27 And so we see a gradual decline in immune function from the age of 20 20:32 to 50, there's a drop and at 60 there's a significant drop. 20:36 Just because you're getting older and just because of how the body's 20:39 is wearing down, people and patients 20:42 in their 40s and 50s need to be thinking about this now. 20:45 And practitioners especially midlife crisis. 20:48 We need to look at how we support the immune system. 20:51 And no wonder 20:51 we see such a rise in chronic disease and cancer rates like never before. 20:55 That's the key of this whole thing, is how to get ahead of it. 20:58 So for the longevity discussion, we need to get this early. 21:01 We need to have this be part of the discussion. 21:03 And then we should hopefully see healthier, better aging 21:07 just instead of having people on feeding tubes 21:09 till they're 100 like we're talking quality of life, right? 21:11 Right, right, right. 21:12 This is it's it's such a blessing. 21:14 So with the research that you've done in the, in compare or 21:17 pairing with and partnering with True Diagnostics, which is, 21:20 I'm assuming what you looked at when you're talking about the immuno. 21:22 Yeah. Age. Right. 21:24 What age groups were you looking at? 21:27 What kind of results? 21:29 What kind of dosing were you doing to be able to see the 21:32 I don't know because I know it's pre published. I don't know. Yeah. 21:34 Yeah yeah. 21:35 So you can't we did a broad spectrum of age. 21:38 The main thing was people have never taken the test before. 21:41 They never taken beta glucan before. 21:44 We're looking at all the different. 21:46 There's 75, again, 75 different biomarkers. 21:48 And we're looking at the organ, 11 different organ systems just to determine 21:52 the dosing was, 1000mg. 21:56 All right. So 1000mg. 21:57 So that would be two capsules. 21:58 So essentially the dosing is 500mg for every 50 pounds of body 22:03 weight for an individual. 22:04 So we wanted to give them a balanced dose. 22:07 It's more of a it it's not like a maintenance wellness dose. 22:10 It's not a chronic disease dose 22:11 that practitioner's like cancer or an integrative oncologist are using. 22:16 But it's one of those balance in between the two. 22:18 So that was that's the study 60 days 22:22 I'm sorry 60 people being on the product for 90 days. 22:26 And I believe the last person just gave in there or just submitted their report. 22:31 So it's always you got to wait for the last stragglers, right, right, right. 22:33 And again, it's really exciting. 22:36 The results are preliminarily pretty, pretty fun. 22:39 But, keep an eye out, keep a look out. 22:41 Check out BW labs.com. And of course disrupt. 22:44 And I hope we'll share more, 22:47 with what we're doing here with the conference and with your podcast. 22:50 So thanks again for having me. 22:51 Yeah, absolutely. My pleasure. I appreciate you being on here. 22:54 I appreciate all the work that you're doing. 22:55 I'm excited to see your research. 22:57 And it will be, as long as we're seeing the great results that I'm anticipating, 23:02 it'll be part of all of our protocols. 23:03 So thank you again, doctor Z, for being here. 23:05 Okay. 23:06 Thanks for listening to the The Longevity Leaders podcast. 23:09 A Longevity Leaders community is on mission to transform 100 million lives 23:13 by 2040. 23:15 If you enjoyed the show, please share this with somebody that you know, 23:18 especially another doctor or physician, but also click that follow button. 23:22 Until next time, stay strong and live long.
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