Full Transcript Introduction to Intravenous Cannabinoids 0:01 If you've been dealing with ongoing 0:01 If you've been dealing with ongoing symptoms for years, seen multiple 0:03 symptoms for years, seen multiple 0:03 symptoms for years, seen multiple doctors, tried different treatments, and 0:06 doctors, tried different treatments, and 0:06 doctors, tried different treatments, and you're still not where you want to be, 0:07 you're still not where you want to be, 0:08 you're still not where you want to be, today I want to introduce something I 0:09 today I want to introduce something I 0:10 today I want to introduce something I would seriously consider much earlier if 0:12 would seriously consider much earlier if 0:12 would seriously consider much earlier if I were starting over. Intravenous 0:14 I were starting over. Intravenous 0:14 I were starting over. Intravenous canabonoids, often referred to as PICO
What the Endocannabinoid System Does 0:17 canabonoids, often referred to as PICO 0:17 canabonoids, often referred to as PICO IV, because what I've seen over the 0:19 IV, because what I've seen over the 0:19 IV, because what I've seen over the years is that when you begin to 0:20 years is that when you begin to 0:20 years is that when you begin to understand how this system in the body 0:22 understand how this system in the body 0:22 understand how this system in the body actually works, you start to see 0:24 actually works, you start to see 0:24 actually works, you start to see possibilities that most conventional 0:25 possibilities that most conventional 0:25 possibilities that most conventional approaches completely overlook. And once 0:28 approaches completely overlook. And once 0:28 approaches completely overlook. And once you see it, you can't really unsee it. 0:30 you see it, you can't really unsee it. 0:30 you see it, you can't really unsee it. And that raises an important question.
Dr. Bloomu2019s Background and Channel Focus 0:33 And that raises an important question. 0:33 And that raises an important question. Hi, I'm Dr. Fred Bloom. I'm an 0:35 Hi, I'm Dr. Fred Bloom. I'm an 0:35 Hi, I'm Dr. Fred Bloom. I'm an integrative and holistic physician. And 0:37 integrative and holistic physician. And 0:37 integrative and holistic physician. And on this channel, we talk about complex 0:39 on this channel, we talk about complex 0:39 on this channel, we talk about complex chronic illness, root causes, and how to 0:42 chronic illness, root causes, and how to 0:42 chronic illness, root causes, and how to actually move forward when things 0:44 actually move forward when things 0:44 actually move forward when things haven't worked the way you expected. If 0:46 haven't worked the way you expected. If 0:46 haven't worked the way you expected. If you find this helpful, go ahead and 0:48 you find this helpful, go ahead and 0:48 you find this helpful, go ahead and like, subscribe, and feel free to 0:50 like, subscribe, and feel free to 0:50 like, subscribe, and feel free to comment as we go. I read them. What I
Why the Endocannabinoid System Matters 0:52 comment as we go. I read them. What I 0:52 comment as we go. I read them. What I want to talk about today is something 0:54 want to talk about today is something 0:54 want to talk about today is something that is still very misunderstood even 0:56 that is still very misunderstood even 0:56 that is still very misunderstood even among physicians and that is the 0:58 among physicians and that is the 0:58 among physicians and that is the endockinabonoid system. Most patients I 1:01 endockinabonoid system. Most patients I 1:01 endockinabonoid system. Most patients I see have never heard of it. Many doctors 1:03 see have never heard of it. Many doctors 1:03 see have never heard of it. Many doctors were never trained in it and yet it is 1:06 were never trained in it and yet it is 1:06 were never trained in it and yet it is one of the most important regulatory 1:08 one of the most important regulatory 1:08 one of the most important regulatory systems in the human body. That's not an 1:10 systems in the human body. That's not an 1:10 systems in the human body. That's not an exaggeration. This system is connected 1:13 exaggeration. This system is connected 1:13 exaggeration. This system is connected to essentially every major system 1:15 to essentially every major system 1:16 to essentially every major system neurologic, immune, hormonal, digestive,
How Dysregulation Shows Up in Chronic Illness 1:20 neurologic, immune, hormonal, digestive, 1:20 neurologic, immune, hormonal, digestive, and its job is very simple. Maintain 1:23 and its job is very simple. Maintain 1:23 and its job is very simple. Maintain balance, maintain stability, maintain 1:27 balance, maintain stability, maintain 1:27 balance, maintain stability, maintain what we call homeostasis. Now, here's 1:30 what we call homeostasis. Now, here's 1:30 what we call homeostasis. Now, here's where it becomes clinically interesting. 1:32 where it becomes clinically interesting. 1:32 where it becomes clinically interesting. If you've been dealing with persistent 1:34 If you've been dealing with persistent 1:34 If you've been dealing with persistent symptoms, not one symptom, but a 1:36 symptoms, not one symptom, but a 1:36 symptoms, not one symptom, but a pattern, fatigue, poor recovery, 1:40 pattern, fatigue, poor recovery, 1:40 pattern, fatigue, poor recovery, inconsistent function, things that don't 1:42 inconsistent function, things that don't 1:42 inconsistent function, things that don't quite make sense together. Very often, 1:45 quite make sense together. Very often, 1:45 quite make sense together. Very often, what I see is not just a single problem. 1:48 what I see is not just a single problem. 1:48 what I see is not just a single problem. It's a loss of regulation. And that's 1:50 It's a loss of regulation. And that's 1:50 It's a loss of regulation. And that's where this system comes in. Because the 1:52 where this system comes in. Because the 1:52 where this system comes in. Because the endockinabonoid system is not just 1:55 endockinabonoid system is not just 1:55 endockinabonoid system is not just another pathway. It's more like the 1:58 another pathway. It's more like the 1:58 another pathway. It's more like the system that helps coordinate all the 2:00 system that helps coordinate all the 2:00 system that helps coordinate all the other systems. And when that system is
Supporting Regulation with Pico IV 2:03 other systems. And when that system is 2:03 other systems. And when that system is not functioning optimally, things start 2:06 not functioning optimally, things start 2:06 not functioning optimally, things start to drift slowly at first, then more 2:09 to drift slowly at first, then more 2:09 to drift slowly at first, then more noticeably, and eventually you end up in 2:12 noticeably, and eventually you end up in 2:12 noticeably, and eventually you end up in a situation where everything feels off. 2:15 a situation where everything feels off. 2:15 a situation where everything feels off. But nothing is clearly wrong enough on 2:18 But nothing is clearly wrong enough on 2:18 But nothing is clearly wrong enough on standard testing, which is exactly where 2:21 standard testing, which is exactly where 2:21 standard testing, which is exactly where many of my patients find themselves. 2:23 many of my patients find themselves. 2:23 many of my patients find themselves. Now, here's the part that most people 2:25 Now, here's the part that most people 2:25 Now, here's the part that most people don't realize. Your body already 2:28 don't realize. Your body already 2:28 don't realize. Your body already produces its own canabonoids. You've had 2:31 produces its own canabonoids. You've had 2:31 produces its own canabonoids. You've had them since before you were born. They 2:33 them since before you were born. They 2:33 them since before you were born. They are essential for development, 2:35 are essential for development, 2:35 are essential for development, regulation, and survival. So, this is 2:38 regulation, and survival. So, this is 2:38 regulation, and survival. So, this is not something foreign. This is something 2:41 not something foreign. This is something 2:41 not something foreign. This is something foundational. And when that system 2:44 foundational. And when that system 2:44 foundational. And when that system becomes depleted, disregulated, or 2:47 becomes depleted, disregulated, or 2:47 becomes depleted, disregulated, or simply not functioning efficiently, the 2:49 simply not functioning efficiently, the 2:49 simply not functioning efficiently, the body loses some of its ability to 2:52 body loses some of its ability to 2:52 body loses some of its ability to self-correct. 2:53 self-correct. 2:53 self-correct. And that's where the concept of 2:55 And that's where the concept of 2:55 And that's where the concept of supporting that system starts to make 2:57 supporting that system starts to make 2:57 supporting that system starts to make sense. This is where Pico IV comes in. 3:00 sense. This is where Pico IV comes in. 3:00 sense. This is where Pico IV comes in. And I want to be very clear here. This
Why Route and Formulation Matter 3:03 And I want to be very clear here. This 3:03 And I want to be very clear here. This is not about recreational use. This is 3:05 is not about recreational use. This is 3:06 is not about recreational use. This is not about getting high. The formulations 3:08 not about getting high. The formulations 3:08 not about getting high. The formulations used in this context are 3:10 used in this context are 3:10 used in this context are non-csychoactive canabonoids. What we're 3:13 non-csychoactive canabonoids. What we're 3:13 non-csychoactive canabonoids. What we're talking about is using plant derived 3:15 talking about is using plant derived 3:15 talking about is using plant derived compounds to interact with a system that 3:18 compounds to interact with a system that 3:18 compounds to interact with a system that already exists in your body to support 3:21 already exists in your body to support 3:21 already exists in your body to support regulation, to support balance, to 3:25 regulation, to support balance, to 3:25 regulation, to support balance, to support the body's ability to do what 3:28 support the body's ability to do what 3:28 support the body's ability to do what it's designed to do. Now, why 3:30 it's designed to do. Now, why 3:30 it's designed to do. Now, why intravenous? Because route matters. When 3:33 intravenous? Because route matters. When 3:33 intravenous? Because route matters. When something is taken orally, it goes 3:36 something is taken orally, it goes 3:36 something is taken orally, it goes through digestion, metabolism, and 3:39 through digestion, metabolism, and 3:39 through digestion, metabolism, and there's variability. When something is 3:41 there's variability. When something is 3:41 there's variability. When something is administered intravenously, it becomes 3:43 administered intravenously, it becomes 3:43 administered intravenously, it becomes more direct, more controlled, and more 3:47 more direct, more controlled, and more 3:47 more direct, more controlled, and more predictable. And clinically, what I pay 3:49 predictable. And clinically, what I pay 3:49 predictable. And clinically, what I pay attention to is not just what something 3:51 attention to is not just what something 3:51 attention to is not just what something does in theory, but what patterns I see 3:54 does in theory, but what patterns I see 3:54 does in theory, but what patterns I see over time. And what I've seen is that 3:56 over time. And what I've seen is that 3:56 over time. And what I've seen is that when this system is supported 3:58 when this system is supported 3:58 when this system is supported appropriately, patients often describe
Entourage Effect and Multi-System Support 4:01 appropriately, patients often describe 4:01 appropriately, patients often describe something interesting, not dramatic, not 4:04 something interesting, not dramatic, not 4:04 something interesting, not dramatic, not extreme, but noticeable. They feel more 4:07 extreme, but noticeable. They feel more 4:07 extreme, but noticeable. They feel more regulated, more stable, more like 4:10 regulated, more stable, more like 4:10 regulated, more stable, more like themselves. And that's a phrase I hear 4:13 themselves. And that's a phrase I hear 4:13 themselves. And that's a phrase I hear often. Let's go a little deeper because 4:15 often. Let's go a little deeper because 4:16 often. Let's go a little deeper because this is where the pattern recognition 4:18 this is where the pattern recognition 4:18 this is where the pattern recognition becomes important. The endockinabonoid 4:20 becomes important. The endockinabonoid 4:20 becomes important. The endockinabonoid system works through receptors 4:22 system works through receptors 4:22 system works through receptors distributed throughout the body. And 4:24 distributed throughout the body. And 4:24 distributed throughout the body. And these receptors influence multiple 4:26 these receptors influence multiple 4:26 these receptors influence multiple pathways simultaneously. So instead of 4:29 pathways simultaneously. So instead of 4:29 pathways simultaneously. So instead of targeting one pathway, you're 4:31 targeting one pathway, you're 4:31 targeting one pathway, you're influencing a network. And when you 4:34 influencing a network. And when you 4:34 influencing a network. And when you combine multiple canabonoids together, 4:36 combine multiple canabonoids together, 4:36 combine multiple canabonoids together, CBD, CBG, CBN, and others, you create 4:41 CBD, CBG, CBN, and others, you create 4:41 CBD, CBG, CBN, and others, you create what's called an entourage effect, 4:43 what's called an entourage effect, 4:43 what's called an entourage effect, meaning they work together across 4:45 meaning they work together across 4:45 meaning they work together across different pathways at the same time. 4:47 different pathways at the same time. 4:47 different pathways at the same time. That's very different from most 4:49 That's very different from most 4:49 That's very different from most conventional approaches, which tend to 4:51 conventional approaches, which tend to 4:51 conventional approaches, which tend to be single target. And that difference 4:53 be single target. And that difference 4:53 be single target. And that difference matters because complex problems often 4:56 matters because complex problems often 4:56 matters because complex problems often require multi-system regulation, not 4:59 require multi-system regulation, not 4:59 require multi-system regulation, not single point intervention. Another 5:00 single point intervention. Another 5:00 single point intervention. Another pattern I've noticed is that many
Who May Benefit and Common Misconceptions 5:02 pattern I've noticed is that many 5:02 pattern I've noticed is that many patients who have been struggling for 5:03 patients who have been struggling for 5:04 patients who have been struggling for years are not necessarily missing one 5:06 years are not necessarily missing one 5:06 years are not necessarily missing one thing. They are missing coordination. 5:09 thing. They are missing coordination. 5:09 thing. They are missing coordination. Their systems are not communicating 5:12 Their systems are not communicating 5:12 Their systems are not communicating efficiently. Their recovery is 5:14 efficiently. Their recovery is 5:14 efficiently. Their recovery is inconsistent. Their responses are 5:17 inconsistent. Their responses are 5:17 inconsistent. Their responses are unpredictable. 5:18 unpredictable. 5:18 unpredictable. And when you start supporting regulatory 5:21 And when you start supporting regulatory 5:21 And when you start supporting regulatory systems instead of chasing individual 5:23 systems instead of chasing individual 5:23 systems instead of chasing individual symptoms, you sometimes see a shift. Not 5:26 symptoms, you sometimes see a shift. Not 5:26 symptoms, you sometimes see a shift. Not overnight, but gradually. and 5:29 overnight, but gradually. and 5:29 overnight, but gradually. and importantly more sustainably. Now, I 5:31 importantly more sustainably. Now, I 5:31 importantly more sustainably. Now, I want to be careful here because this is 5:33 want to be careful here because this is 5:33 want to be careful here because this is not for everyone and this is not 5:35 not for everyone and this is not 5:35 not for everyone and this is not something I would apply universally. So, 5:37 something I would apply universally. So, 5:37 something I would apply universally. So, let's talk about who should pay 5:39 let's talk about who should pay 5:39 let's talk about who should pay attention. If you're someone who has 5:40 attention. If you're someone who has 5:40 attention. If you're someone who has tried multiple approaches and things 5:42 tried multiple approaches and things 5:42 tried multiple approaches and things help a little but didn't fully resolve 5:45 help a little but didn't fully resolve 5:45 help a little but didn't fully resolve if your symptoms seem to involve 5:47 if your symptoms seem to involve 5:47 if your symptoms seem to involve multiple systems rather than one 5:49 multiple systems rather than one 5:49 multiple systems rather than one isolated issue. If you've been told your 5:52 isolated issue. If you've been told your 5:52 isolated issue. If you've been told your laps are normal but you don't feel 5:55 laps are normal but you don't feel 5:55 laps are normal but you don't feel normal, then this is something that may 5:57 normal, then this is something that may 5:57 normal, then this is something that may be worth understanding. Not necessarily 5:59 be worth understanding. Not necessarily 5:59 be worth understanding. Not necessarily jumping into but understanding. On the 6:02 jumping into but understanding. On the 6:02 jumping into but understanding. On the other hand, if someone is doing well, 6:05 other hand, if someone is doing well, 6:05 other hand, if someone is doing well, stable, recovering appropriately, this 6:07 stable, recovering appropriately, this 6:07 stable, recovering appropriately, this may not be necessary and that's 6:10 may not be necessary and that's 6:10 may not be necessary and that's important because good medicine is not 6:12 important because good medicine is not 6:12 important because good medicine is not about doing everything. It's about doing 6:15 about doing everything. It's about doing 6:15 about doing everything. It's about doing the right thing for the right person at 6:18 the right thing for the right person at 6:18 the right thing for the right person at the right time. There's also nuance 6:19 the right time. There's also nuance 6:20 the right time. There's also nuance here. This is still an evolving area. 6:23 here. This is still an evolving area. 6:23 here. This is still an evolving area. There's still education needed even 6:25 There's still education needed even 6:25 There's still education needed even among practitioners. There are still 6:27 among practitioners. There are still 6:27 among practitioners. There are still misconceptions. 6:28 misconceptions. 6:28 misconceptions. One of the biggest being that anything 6:30 One of the biggest being that anything 6:30 One of the biggest being that anything related to canabonoids is automatically 6:33 related to canabonoids is automatically 6:33 related to canabonoids is automatically recreational or psychoactive. That's 6:35 recreational or psychoactive. That's 6:35 recreational or psychoactive. That's simply not accurate. And that 6:37 simply not accurate. And that 6:37 simply not accurate. And that misunderstanding has slowed down 6:38 misunderstanding has slowed down 6:38 misunderstanding has slowed down progress in this area. Another important
Restoring Coordination in Complex Illness 6:41 progress in this area. Another important 6:41 progress in this area. Another important point, this is not a replacement for 6:44 point, this is not a replacement for 6:44 point, this is not a replacement for everything else. This is not a shortcut. 6:47 everything else. This is not a shortcut. 6:47 everything else. This is not a shortcut. This is not a standalone solution. It's 6:49 This is not a standalone solution. It's 6:49 This is not a standalone solution. It's one piece of a larger strategy and when 6:53 one piece of a larger strategy and when 6:53 one piece of a larger strategy and when used appropriately it can complement 6:55 used appropriately it can complement 6:55 used appropriately it can complement other approaches by improving regulation 6:58 other approaches by improving regulation 6:58 other approaches by improving regulation which then allows other therapies to 7:00 which then allows other therapies to 7:00 which then allows other therapies to work more effectively. If I look back at 7:02 work more effectively. If I look back at 7:02 work more effectively. If I look back at how I approached patients earlier in my 7:04 how I approached patients earlier in my 7:04 how I approached patients earlier in my career, I focused more on individual 7:07 career, I focused more on individual 7:07 career, I focused more on individual problems, infections, 7:09 problems, infections, 7:09 problems, infections, toxins, 7:11 toxins, 7:11 toxins, hormones, and those are still important. 7:13 hormones, and those are still important. 7:13 hormones, and those are still important. But what I've learned over time is that 7:15 But what I've learned over time is that 7:16 But what I've learned over time is that unless the system as a whole can 7:18 unless the system as a whole can 7:18 unless the system as a whole can regulate, you can correct individual 7:20 regulate, you can correct individual 7:20 regulate, you can correct individual pieces and still not get the result 7:23 pieces and still not get the result 7:23 pieces and still not get the result you're looking for. And that's one of 7:25 you're looking for. And that's one of 7:25 you're looking for. And that's one of the reasons this topic matters because 7:28 the reasons this topic matters because 7:28 the reasons this topic matters because it shifts the focus from fixing parts to 7:31 it shifts the focus from fixing parts to 7:31 it shifts the focus from fixing parts to restoring coordination. So the takeaway 7:34 restoring coordination. So the takeaway 7:34 restoring coordination. So the takeaway here is not that this is the answer. The 7:36 here is not that this is the answer. The 7:36 here is not that this is the answer. The takeaway is that this is a system that 7:39 takeaway is that this is a system that 7:39 takeaway is that this is a system that most people have never been taught about 7:41 most people have never been taught about 7:41 most people have never been taught about that plays a central role in how the 7:43 that plays a central role in how the 7:43 that plays a central role in how the body maintains balance and that can be 7:46 body maintains balance and that can be 7:46 body maintains balance and that can be supported in ways that are very 7:48 supported in ways that are very 7:48 supported in ways that are very different from what most patients have 7:50 different from what most patients have 7:50 different from what most patients have experienced. And I'll leave you with a 7:52 experienced. And I'll leave you with a 7:52 experienced. And I'll leave you with a few questions. Has anyone ever explained 7:54 few questions. Has anyone ever explained 7:54 few questions. Has anyone ever explained the endockinabonoid system to you in 7:56 the endockinabonoid system to you in 7:56 the endockinabonoid system to you in this way? Does this idea of regulation 7:59 this way? Does this idea of regulation 7:59 this way? Does this idea of regulation versus symptom treatment match your 8:01 versus symptom treatment match your 8:01 versus symptom treatment match your experience so far? And would you want me 8:04 experience so far? And would you want me 8:04 experience so far? And would you want me to go deeper into how this fits into a 8:06 to go deeper into how this fits into a 8:06 to go deeper into how this fits into a full treatment strategy? Because for 8:08 full treatment strategy? Because for 8:08 full treatment strategy? Because for many people, I see this is the moment 8:11 many people, I see this is the moment 8:11 many people, I see this is the moment where things start to make more sense. 8:13 where things start to make more sense. 8:13 where things start to make more sense. Not because it's complicated, but 8:15 Not because it's complicated, but 8:15 Not because it's complicated, but because it connects the dots in a 8:17 because it connects the dots in a 8:17 because it connects the dots in a different way.
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