Full Transcript Podcast Intro and Regenerative Medicine Overview 0:00 Hey there, welcome to the Recharged Biomedical Podcast. 0:03 I'm Dr. 0:03 Edward Park. 0:04 If you're curious about regenerative medicine, you've come to The Right Place. 0:08 We're diving into the latest breakthroughs in telomerase activation, stem cell exosomes, and all the cutting edge science that's shaping the future of 0:15 healing and longevity. 0:16 Let's get started. 0:18 Hi everybody, this is Dr Ed Park and today we're doing a lecture about facial rejuvenation, which is something that obviously everyone can benefit from. 0:28 The first slide shows me 20 years ago, 26 years, ago I was very obese. 0:34 I started taking TA-65 and I shed the visceral fat rather quickly. 0:38 But I don't think I looked that young. 0:39 Occasionally I will get carted for alcohol, which I do not understand. 0:45 Here is my picture from a year and a half ago. 0:49 Obviously, good favorable lighting. 0:52 If I had unlimited resources, I would probably do micro-nataling with exosomes more often. 0:57 So this is from my book, Telomere Tymons and the Telomeric. 1:03 And it just shows that telomeres shortening is at the heart of all diseases. 1:08 It's one disease, it affects all cells, especially stem cells.
Facial Rejuvenation and Aging Background 1:13 I believe that taking TA-65 has helped to slow that process. 1:18 When we look into what aging is, here's a list of premature aging syndromes. 1:25 And what you can't really read is the phenotype of osteoporosis, wrinkled skin, hair loss, and depigmentation. 1:34 These are all very typical of these premature aging syndromes. 1:37 And the gal to my side here has one of this and she's looking old, even though she is probably only seven years old. 1:46 And you can get this dyskeratosis congenita from any of these three components above me. 1:51 The reverse transcriptase enzyme, which prints out new telomeres, Which are the ends of chromosomes that protect them from damage. 1:59 Or the Turk template or the dyskaren key to the lock. 2:06 So everyone wants to look their best. 2:07 They want to like younger. 2:08 We've known about Botox for decades, fillers as well. 2:12 These are temporary solutions to a ongoing problem. 2:17 Of course we have the crow's feet, the frown lines, glabella area. 2:24 marionette lines this is all because of loss of elasticity thinning of the skin the sunken eyes is loss at the adipose fat pad then we have degradation 2:36 of extracellular matrix the stuff even in between the cells like hyaluronic acid This can be caused by glycation. 2:43 People say that inflammatory diets worsen it, which I probably have too much sugar in my diet. 2:49 Of course, UV, A and B, cell aging and stem cell attrition and damage, epigenetic changes, these are all constant work. 2:59 This graph shows that people spend a lot of money to try and look younger. 3:04 And it doesn't actually include it's the songs, which is also a billion dollar market. 3:09 And for good reason. 3:11 I want to take a detour to my most famous case, this guy Richard, who documented over the course of two weeks his improvement in everything. 3:20 And he basically had a leaky gut, and it was causing inflammation. 3:28 After exosome treatment, he must have sealed his gut. 3:32 So this lining here was letting food particles into his bloodstream, causing an allergic reaction. 3:38 I think the most prominent thing is two weeks later, this 49-year-old looked younger because you see all the inflammation, 3:47 swelling, the eczema, even the veins in his legs, spider veins went away, which was quite remarkable. 3:55 So inflammation is the result and cause of aging, we might say. 4:00 But ironically, Kim Kardashian is putting her blood on her face, her PRP, and getting microneedled.
Inflammation, Exosomes, and Skin Repair 4:08 So PRP got popular about 15 years ago. 4:11 They take your blood, they spin it, and they take this platelet-rich fraction and then they microneedle it into your face. 4:18 So how can inflammation reverse aging? 4:20 Well, we see the curve from my book, Exosomes, Salms, & Healing, And it shows that initially when you get an injury, there's inflammation, 4:28 which brings in your mesenchymal stem cells, They secrete exosome and shut down the inflammation and rebuild the tissue. 4:35 So the FDA has approved microneedling for scar or facial wrinkles, and that's for people 22 or older. 4:44 And that means they think it's safe and effective. 4:46 So even without exosomes or any biologics, just the fact of damaging causing inflammation will in most cases improve the appearance and that's because 4:57 of the natural human response to inflammation that is stem cell recruitment and secretion of exosomes. 5:05 Now what are we doing with laser and radiofrequency? 5:07 Now they have these Morpheus micro-needling with radio frequency. 5:11 We're just causing tissue damage by and large. 5:15 causing an injury, a burn, and these are some of the targets of a different wave race. 5:20 For many years, I practiced injections and also lasers. 5:23 I had an ND YAG 1064, had a KTP, an Erbian, which was great for resurfacing as well. 5:32 So again, in the context of exosomes, they could be such a great adjunct. 5:38 After you do your ablative procedure, you put exostomes on and it skips this whole hemostasis inflammation goes right to proliferation and remodeling. 5:48 That's how exocells work. 5:50 They change the way that the T cells are behaving to a more regenerative mode. 5:58 So it's good to be aware of the Fitzpatrick scale, type 1 to 6, according to someone's darkness or melanin content. 6:08 If you are lighter, it means your ancestors evolved in vitamin D poor areas, and so you need more vitamin d. 6:16 Of course, when you have more melanine, there is the risk of post-methylalanine hyperpigmentation. 6:21 As you see, this woman, probably South Asian, has some streaks from laser treatments. 6:27 And that's because the inflammation can cause post-inflammatory hyperpigmentation. 6:32 So you have to be cognizant in that. 6:35 Three plus four, five, six, the darker skinned people. 6:39 When I was doing laser, I would prevent this. 6:41 I found some obscure paper. 6:43 It was from a Southeast Journal. 6:46 Surprisingly, a lot of my dermatological patients They kind of said, oh, I got post-inflammatory hyperpigmentation. 6:54 And so the germs don't really know about this, but we would mix. 6:57 I would compound a bleaching cream, which prevents melanin synthesis and a steroid and start that around day 10. and that would obviate or preclude the 7:08 post inflammatory hyper pigmentation, even after very inflammatory laser treatments. 7:13 So what are we doing with exosomes? 7:16 Well, they're anti-inflammatory. 7:17 They regenerate skin, vasculature, and elasticity by leveraging the body's own natural systems, but without the inflammation. 7:24 Notice that when you do PRP, it's how you don't take Advil or Motrin for a week because they want the information. 7:31 We do not want information, we don' want to take that risk or that bargain. 7:35 So possible applications would be skin burns. 7:38 This patient to the left had a horrific burns on her face and we gave her weekly injections and it cleared up very, very nicely. 7:46 Eczema, which is something I've had lifelong, acne. 7:49 We also will see a treatment of my son who had acne as a teenager. 7:54 But it's a great adjunct anytime you're doing laser or, you know, any kind of healing procedure on the face. 8:01 I've taken up golf recently again, and you see these punch screens, they put holes in the green. 8:06 It's kind of the same process. 8:08 They want to bring air in and the damage to the greens brings in healing potential. 8:14 So what we're really doing with the micro-kneeling is causing holes, damage, physical damage. 8:20 And we are hoping that the inflammation again and then the proliferation comes in. 8:24 Fibroblasts, mosaical stem cells, exosomes, it's all very, very natural. 8:30 When we look at the cross-section of the skin, we have the outer sort of almost water-grouped layer. 8:34 There are water channels, but we want to make holes to seed the other skin. 8:39 So we need to get through the dry dead skin layer, the stratum corneum, and then under that is the epidermis and the dermis.
Microneedling Technique and Skin Prep 8:47 Stem cells are throughout, nerves are through out, largely in the germopapillae. 8:52 That's where a lot of stem cells reside. 8:55 Now, everything is a practice of medicine. 8:58 It's not a mastering of Medicine. 8:59 And when I first started out, I was using a lot of benzocaine, lidocane, tetrocane or BLT. 9:05 it's a common formula, 20% benzocate, 8-lido-8-tetra. 9:10 If something that you have to keep refrigerated in some cases, sometimes they can make it so you don't have refrigerate it. 9:17 And you can use an occlusion app like cellophane, 20 to 30 minutes is the max. 9:22 If you put it on longer, it will cause too much absorption. 9:25 You'll get a headache. 9:26 It's not great. 9:28 But it does work if you're going to go deep. 9:30 And what do we define as deep? 9:31 Well, if your going do fractional laser or something like even RF, Morpheus, these things hurt a lot. 9:38 Now if we're doing deep scar revision CO2, which I don't love, I love erbium better because it's more adjustable. 9:45 But you can look at the depth, right? 9:47 So the dermis is about a millimeter depth depending on the region. 9:51 And it's going to hurt. 9:52 So you're probably going need BLT. 9:54 These are the different depths. 9:56 The commonly used machines, we have a little radial dial that you could dial from 0 to 2.5 millimeters depth. 10:04 You have pretty precise control over that. 10:07 Skin cleansing is an interesting thing. 10:09 Of course, you want the person to cleanse their face, take off their makeup. 10:13 Some people use alcohol, other people don't like it, it smells, kind of stings. 10:19 It can sting, evaporates quickly, but it can be drying and irritating to the skin. 10:24 One really good option, which is less toxic, is hypochlorous acid, Skinsmart or Griotek, non-toxic, and you don't need to rinse it, 10:33 it'll evaporate off. 10:35 I prefer Betadine because I carry Betadyne all the time, but I also use a sterile normal saline to wipe it off afterwards because you want the Betadiene. 10:44 staining the skin, but that is very, very broad-spectrum antimicrobial. 10:49 The treatment, you'll see at the end, was done with chlorhexazine at first, then I encouraged my friend and nurse to use Betadine. 10:57 Chlorhexyzine is okay. 10:58 It is toxic if it gets in the eyes, so that's not great, or the ears. 11:03 You can dilute it all the way down to 0.05. Hypocleans is a commonly used one, again, we used to this in surgical prep. 11:11 but I don't like it near the eyes. 11:13 Witch hazel is something that Dr. 11:16 Martin recommended, but it's not that antimicrobial. 11:20 Probably better after treatment. 11:22 But keep in mind that this is not like a sterile procedure. 11:25 We're not really, you know, it's not going into the abdominal cavity or joint space, God forbid. 11:30 The skin, including the scalp, is very well vascularized and very resistant to infections. 11:35 Now, that said, if somebody has an active perpetic lesion, I would delay the treatment for another day because exosomes do shift the phenotype away from 11:44 antibody production into regeneration. 11:48 So this is the one I'm currently using. 11:50 They have a Dr. 11:51 Pen MAS. 11:53 I used to use seven, but the cord is a drag, the Cordless is easier. 11:57 they have nine, they had a ten, They're all running around $100. And the cartridges are only two or three bucks each. 12:05 The good thing is you can adjust the frequency and the depth quite easily. 12:09 So these are obviously sterile single-use things. 12:12 and I will use a urine cup. 12:16 These are also very good. 12:17 Anything that's sterile, we want to keep it as clean as possible. 12:21 The cosmetic brush is a great thing. 12:25 It's not strictly steriled, of course. 12:27 You could do that. 12:29 But it's very great for application. 12:31 it feels nice going on. 12:32 And that is what I use. 12:34 Alright, so when I was last year in Cancun giving lectures on exit songs, I met this guy, Scott Martin, who reps for another company. 12:43 And that's me singing Mariachi, but he gave a really interesting lecture about why not to use BLT and I did shift my practice. 12:50 So if I ever update the online training, I will include that because the BLT is cumbersome. 12:58 Again, there's some systemic absorption, but most importantly, it's acidic and it can kind of degrade the exosomes, which is what we want. 13:05 So I think of it like a creme brulee, right? 13:07 So you have that charred, very thin layer on top. 13:10 We're just trying to get more channels than what exists. 13:13 The water channels are there, but we're trying make thousands of little holes so that the exosomes can be put into the epidermis, 13:20 perhaps even the dermis. 13:21 And what you'll come to find is that if you do less than 0.5 millimeters, yeah, there are nerves, it's really quite painless. 13:29 With the exception of maybe an elderly person on the forehead, you might hurt a little bit, and you dial it back to 0,3. or under the eyes where it's very thin. 13:38 But in general, if you're keeping it under 0.5 millimeters, you don't need anesthesia and you are making the holes for the exosomes to go into. 13:46 This is years ago, what six years, ago my son was having nodulocystic acne and it was over a year. 13:52 He was trying to do oriental medicine, other things, lights didn't really help. 13:56 So antibiotics didn' help, benzoyl peroxide, alkyl hydroxy acid, all this stuff. 14:03 It's just part of being a teenager and having, hypertrophic Sabatia squats right so we decide to try micro needling we microneedle put some exosomes in
Treatment Demo and Results 14:14 there and the nodularity decrease the amount of inflammation decrease nine months later he was. 14:21 Much much better after just two treatments earlier. 14:24 This is one of my favorite patients. 14:25 She, she actually flew out the next day to have her son treated. 14:29 He had a terrible genetic accident, but Allegra had 11 kids, a former investment banker, wonderful person. 14:36 Even had multiple sclerosis, which she somehow. 14:41 flew to eastern europe and got treated with a interesting jugular venous stent but all that aside she said hey can you do anything to help my parents and 14:50 then she sent me a bunch of pictures i mean it's better light and makeup but at 49 with 11 kids Jess stated she had signs of aging and she was happy. 15:01 She did do the five mil higher priced version, but that was after one treatment in one month. 15:06 Just last year, our good friend Bob, his sister said, Hey, I got a spider bite two weeks ago. 15:17 But, um, they were talking skin graft. 15:19 She was hospitalized. 15:20 It was nasty. 15:21 So when I saw her on the day of treatment, this is what it looked like. 15:24 Clearly necrotic. 15:26 I just put a tiny bit of Luxir at the periphery and my goodness, six days later, it's like nothing had happened. 15:32 so it must have rebascularized the area and shut down the necrosis, which is remarkable. 15:40 So what are our options? 15:41 You know, we have the baby in the bath water. 15:44 So a lot of the products out there are lyophilized, let's say freeze-dried. 15:49 Like Benev, it comes from obese Korean men. 15:52 They do liposuction and they're maybe not stem cells. 15:55 There may be just adipocytes, maybe some rare stem cell in there. 16:00 And they collect the exosomes and then they freeze dry them. 16:04 Does that work? 16:04 Yeah, probably it helps. 16:06 The micro-needing itself is helpful, but the This is like a billion, multi-billion dollar company, and they just have good marketing and market share. 16:16 We use Luxir. 16:18 Luxier, of course, is micro-filtered, nanofiltered really, size exclusion and inclusion. 16:24 So what does that mean? 16:25 When you grow a stem cell, it secretes a bunch of stuff, even like the waste products, the products of apoptosis are in there. 16:33 Some people allege that it's better to have all the condition media, all of the products. 16:38 I don't necessarily believe that. 16:40 If we're looking for pure exosomes, we are looking at size, inclusion and exclusion. 16:44 So if you're just wanting a product for the face, the Chiara is not size inclusion. 16:51 Everything is smaller. 16:52 All the little stuff in the stew and the broth is in there. 16:56 If you do size inclusion, it's much more expensive, that's a pure product between 40 and 160 nanometers, let's say. 17:03 That's something you can give IV, even if I use it intrathecally in the joints, ultra-pure size-inclusion. 17:10 But if you're just allowing all the small stuff, molecules, little debris, That is a Kiara product. 17:16 And the Veev product is the legacy product, which has amino acids, and some of the sulfur moiety smell like rotten eggs, 17:23 so they put rose water. 17:25 Never use Veev internally, only topically. 17:28 So that's a good price point right there with the banana. 17:31 But if you want to do cheaper, like a series, a package of treatments once a month for three months, Kiara may be the way to go. 17:39 You can even dilute it and you can see your price points there for one to five, six to 14 and 15 plus. 17:46 And you could purchase that directly through us and the chips the next day too. 17:51 So that's really a lot of the products on the market are maybe not size inclusion filter. 17:56 So they are conditioning media and people say it's better. 17:59 I don't necessarily believe that. 18:02 When we do microneedling, I have a separate consent, which you can download from the online course. 18:08 Again, they'll wash your face and then we will clean with Betadine. 18:11 And then I use sterile normal saline to wash the Betadyne off because it can kind of stain. 18:18 You don't necessarily have to have 100% thaw because as you're doing it, it will thw. 18:22 But pour into the sterile cup and be careful that the weight of the cosmetic brush doesn't tilt the cup. 18:27 That's a disaster. 18:28 Usually won't. 18:29 I use steril ultrasound gel to glide. 18:32 You could argue that clogs the pores, but you'll see it in the video demo that you can wipe it off and you still have holes there. 18:40 Again the new technique, the crème brûlée technique is only 0.3 to 0,5 depth and it just feels like a cat licking you. 18:46 Really not painful at all. 18:48 We do section by section. 18:49 You can see this is the view of the provider. 18:51 I'll usually start on the forehead, one side and then make my holes clean with the sterile gauze and apply the excess. 19:00 So I'm going to do the other side of that forehead and we'll do that entire cheek. 19:04 we might need to adjust by the side the eyes or under the eye where it's thinner because it'll hurt more. 19:10 And then we'll do the application. 19:12 I'll be the other cheek and then I do a center of the face, nose, lips, chin. 19:16 And if we're doing, if you have enough product, we do that. 19:19 This is an upside down picture of me I took today. 19:22 You know, I'm 59, and I don't have great skin, eczema, a lot of inflammation, my diet, lifestyle, but I anticipate it'll get better even in the weeks to come. 19:32 So this is something you can do. 19:34 Microneedling is FDA approved with or without exosomes. 19:38 That's a different story. 19:39 There are lyophilized brands, but they come out to be the same price really as Chiara or Veve. 19:46 And so I tend to, you know, like to splurge and use the five nil Luxir and that is a good product.
Q&A, Course Promotion, and Closing Remarks 19:54 If you are interested in doing this, you can keep it on the download. 19:58 Just spend a hundred bucks to get a doctor pen and then order X-Somes. 20:02 I think you might like it. 20:03 Most people do. 20:04 We're going to watch a video demo of my last week's treatment. 20:07 And if you're interested purchasing, You can go to rechargephilemaple.com slash masterclass where we described the course. 20:13 It's online, 15 hours. 20:15 we just added an autism treatment modules. 20:18 You cannot download all of our forms for patient intake, pre and post consenting. 20:25 There's one sheet for your medical assistant to prep all the things and find your steps we take in the physical exam and you can buy excess homes and watch 20:34 video demonstrations there as well. 20:36 When you purchase the course you get a never-expiring credit which we will give you back as excess home purchases. 20:43 And you are also on our email list for learning about these monthly webinars. 20:50 So let's open it up to questions and I'm going to show you the video of my treatment last week. 20:56 If I can find it. 20:58 Let's see if I could find. 21:01 This is my face. 21:02 It's kind of ragged from a lot of sun exposure, eczema, inflammatory diet. 21:11 She's just prepping the skin with a little beta dye. 21:19 You could wipe it off with normal saline if you want. 21:22 Do you have normal Saline? 21:24 You need a normal Sally? 21:25 Just to wipe that off. 21:26 Okay. 21:29 So nurse Casey has applied the beta-diagnosis, just washing it with a little normal-saline. 21:40 And then she's going to apply gel to help it glide. 21:47 and then wipe the gel off and painted the exosomes with a cosmetic brush. 21:55 Because we don't go deeper than 0.5, it doesn't hurt. 21:59 There's no nerve endings, so we do not need to go use anesthesia, no benzocaine, lidocain, tetrocaine in this technique. 22:14 Okay, so just do like gel Mm-hmm. 22:17 Okay and then microneedle and paint. 22:21 But you have to wipe off the gel. 22:23 A little gel Just a little yeah, okay. 22:34 Then you mean the stamp, right? 22:36 No stamp just paint It doesn't hurt because it's only 0.4 millimeters. 22:50 Wipe off the gel with the dry sterile one. 22:53 Okay. 23:03 And then spray it. 23:05 That's it? 23:06 Painting, yeah. 23:21 I feel that a little bit in the under eye section just because the skin is thinner, but it still doesn't hurt. 23:27 And notice it's not bleeding. 23:34 So this technique, we're just penetrating the stratum corneum, just enough to plant the seeds, the exosomes. 23:43 So we're all finished up, even the neck. 23:46 Just getting all five CCs of the beautiful Luxier Pure Exosomes. 23:51 And hopefully it'll tighten and brighten everything up. 23:54 Thanks, Stars Casey. 23:56 Well done. 23:59 Okay. 24:01 You can see right after, there's really not much redness or irritation. 24:06 So painless, quick procedure. 24:08 Overall, I expect the results to be good, as they usually are. 24:12 That's it. 24:14 Microneedling with exosomes. 24:24 All right. 24:25 I guess we answered all the questions. 24:27 As Denise said, we have video demos of shoulders, knees, even epidural. 24:32 That IV, that's pretty easy to do, I hope. 24:35 Nasal is our most popular treatment, and we've been doing that a lot for neuroinflammation. 24:43 Okay. 24:44 That's pretty much it. 24:45 Everyone is completely satisfied. 24:49 No questions. 24:51 Alrighty. 24:52 Well, this is Dr. 24:53 Ed Park completing a lecture on facial rejuvenation. 24:57 And I think the sort of light motif I want to get into everyone is that you can't really stop aging. 25:05 But transiently, you could use inflammation, micro-needling, exosomes to kind of mitigate. 25:11 And I've been using TA65. 25:13 I believe that's been helpful. 25:15 It can read inches away like this because it kept my lens off. 25:20 So these are little hacks that we have. 25:23 Again, I don't think I'll be carded for alcohol. 25:27 for much longer, but I'm enjoying it while it's lasting. 25:30 So anyway, if you have any questions, you can contact me offline, Dr. 25:34 Park at rechargebiomechanical.com. 25:37 If you like this content, please like and subscribe and every month we'll do a different sort of provider webinar for you to learn. 25:45 Thanks everybody for attending and appreciate you. 25:48 We'll see you next time. 25:51 Many clinicians are getting interested in exosome therapy and they hesitate for good reason. 25:56 Questions like, does this work? 25:58 What forms do I need? 25:59 How much should I charge? 26:01 how do i stay out of trouble? 26:03 All these questions are addressed in my online course. 26:05 That's why I created it to help you get started. 26:08 The online Course is your permanent turnkey resource to get start either treating yourself, friends and family or to expand your practice and help more 26:18 people as well as increase your revenue. 26:21 Thanks for tuning into the Recharged Biomedical Podcast. 26:24 If today's episode got you thinking, you'll love my book, Exosomes, Songs of Healing. 26:29 It's packed with cool analogies, full color illustrations, and all the science you need to understand how exosome are changing the game in aging and regenerative medicine. 26:39 You can grab it in paperback, ebook, or audiobook, whatever works for you. 26:43 Now head over to www.rechargedbiomedical.com to check it out. 26:49 And don't forget to like and subscribe so you never miss another episode. 26:53 See you next time.
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