Turn Back Time With Oral Peptides And Bioregulators

Kent Holtorf, MD

But thank you so much for having me. I just love this whole topic and how it’s just changing patients’ lives and transforming doctors’s practices, and you’re just a wealth of information as well. I was just honored to be invited to the Peptide Summit. Thank you.

Jen Pfleghaar, DO, ABOIM

Yes, of course, Dr. Kent. Now, one thing that I remember you speaking at ILADS, I remember stepping into the room, this was my first introduction to peptides and hearing your story about how sick you were how peptides changed your life, and how that pain that you had brought, the purpose of you getting peptides out to the masses through oral peptides. Could you go over that with our audience?

Kent Holtorf, MD

I’ll give you the short version. You probably heard the story, but, going through it,  I was born at like six months and was supposed to either die or be retarded. I have excuses for a lot of things and have always had weird things going on growing up, the very functional. No problem. But, like, one pupil was always bigger than the other. Like, half the side of my body would be freezing, half their young, and strange things like that. But then, as I started going through college or medical school, I got. Something’s going on. I’m just fatigued, and mentally, I couldn’t tolerate anything. Then it got worse and worse. I go to the university doctors, and they say, you’re depressed or stressed. Here’s an antidepressant. I’m not depressed. I just took them for short periods, and they didn’t do anything. It got so bad. We were just talking to a patient was just overwhelming to me, and so I said, I don’t know what I’m like; I can do medicine, but I say, Let me go into anesthesia because I want to talk to patients who are sleeping. But so, I started doing that, and it was ingrained in medical school, which I’m in at all hours, and I’m sure it is a place where anything alternative integrative functional means no evidence. It was very evidence-based. I’m still very evidence-based. What am I going to do? I’m not going to go to those quacks, but then, as I got sicker and sicker, I went let me snuck off. I didn’t tell anyone and went to some alternative conferences. I’m like, “What the hell? They’re more evidence-based. the stuff that they’re teaching us in residency,” 

So I ended up doing, I guess there’s the chronic fatigue syndrome. Again, all these syndromes have the same thing and the same underlying mechanisms. They just manifest differently. But then I form an optimization and thyroid optimization. High-dose T3 was a lifesaver. That was a major thing in some immune modulation and some antimicrobials.  I’m like, I’m a new person.  So I’m under anesthesia. I’m like, I hate anesthesia. No offense to an anesthesiologist. But it’s like, to me, it was mindless, like, here you go. and so I got out of anesthesia, went into family practice, and started essentially doing, I got one optimization, and just everything just took off, and that’s how I started a beer company, as well as having a hangover-free beer, double-blind, placebo-controlled studies. But, long story short, then, when I was married, I went through a very bad divorce, and this is what stress is, I’m telling you, especially emotional stress. Then I became bedbound, just horrible sweating, Allodynia where your skin you can’t even touch when it hurts, terrible cognitive function, night sweats, and muscle pain. I was just taking, like, ten showers at night, and all these things, I was just totally nonfunctional. I couldn’t stand up. I couldn’t breathe and went to the cardiologist, and he said, “Your heart is like, broke. It’s not filling. You maybe can get 10% better in ten years.

I couldn’t stand up. I couldn’t walk upright. I’m like, I’m not going to live like this. I decided on Halloween that I’d get myself to Halloween, and I’m going to end it. But I’ll try whatever till then. I went around the country and the world. I bought a lot of good treatments and dendritic cell therapy that were simulated for Lyme antigens with Omar down in Mexico. Ozone helped, and a lot of immune-monetary stuff helped. I was in Belgium and had some peptides I was reading about, and I got some peptides I wrote about and things that happened. Then, four or five days later, I just walked up the stairs. “Wait a minute. What the heck?” I’m like, trying to backtrack. Like, well, I don’t think it’s a peptide. What else did I do? It turns out again, it’s peptides. I’m like, I’m feeling so much better.  then started combining them, and then was able to, over time, bring them back to the US. then they started being available from some of the major company pharmacies. It just changed my life and practice as well.  I go into cardiologists, standing up, and he looks at me and goes, “You look pretty good,” Or something like that. I’m like, “Oh, yeah.” He goes, “Well, get on with 2D echo, and your heart’s normal.”

Did he ask me what I did? No, he goes, and I’ll see you in a year. But that’s the way that they work. But so I thought in the back of my mind that, this is going to help me one day. But people have had Lyme, Babesia, and Bartonella. It is horrible, and you can’t explain how bad you feel every day. The people are seeing this; everyone’s sick. I go to parties, and I have to bring lab slips because everyone’s like, “I’m sick. My daughter is sick.” It is terrible, it’s multifactorial. But you know, in the US, we have twice the level of chronic illness as any other developed country.

Jen Pfleghaar, DO, ABOIM

It’s crazy how sick people are. It’s great when we hear stories like yours about how you reversed the disease. You’re feeling so good that you’re running all these companies and advocating for patients. When we talk about peptides, we have to talk about the thymus. How do peptides help the thymus? What role does the thymus have in aging?

Kent Holtorf, MD

It’s very interesting. As you get older, your thymus modulates the immune system. It’s very complex. But a good way to look at it is to break down TH1. You can break it down and make it and adapt it. But clinically, this works better. TH1 gets stuff inside the cell. TH2 gets stuff outside the cell. Not a TH1 cell, but natural killer cells, a downstream marker for that. Natural killer cell function is our main marker for TH1, and then for TH2, is C48, and so what happens is that as the thymus involutes over time, it drops down to its lowest point, right around 40 or 45. That’s when you start getting all those diseases of aging. So the TH1 goes down now; you can’t fight intracellular infections. That’s also what fights cancer. But you have all this inflammation. it’s an H-phenotype. It’s a sick phenotype of the immune system. You can look and see. It’s the biggest determinant of your biological age is your immune system.

Jen Pfleghaar, DO, ABOIM

I can believe that. But even with younger people, we’re seeing an TH1 and TH2 imbalance. How would you explain that?

Kent Holtorf, MD

If everything is stressful, it will cause it to involute much quicker obesity, certain vaccinations, of how like that, that we were checking every time that, they got this procedure, that we would check their natural killer cell function and their coagulation, and we look at their blood on a live cell thing, and it would just natural killer cell function every time that did that. Their inflammation will go up, and their blood cells are certain to be clumping together. and all their coagulation markers would go up. So it just came out like it was two days ago, showing that if you had more than three boosters that you got printed in, if they came out with an almost count, like, what was the purpose of this? With a variant that’s much more lethal. The people who are vaccinated locally won’t recognize it. They will have no defense against it. It’s also like when you get the flu shot, you are twice as likely to get the flu the next year, I don’t want to have all the vaccines and stuff like that. People get crazy, but it’s everything: toxins, pesticides. We’re the toxins being put to death. and anytime you lower the immune system and have toxins, you set up autoantibodies. Then you get antibodies to the brain, and we can talk about the veteran stuff that we’ve been doing. But, yes, everything’s a vicious cycle. It’s also the food. It’s like we’re just being poisoned everywhere. The stresses, like, everyone just stressed out of their minds.  When I was growing up, we didn’t have computers. He’d send a letter off and wait two weeks, and I was carefree. Now it’s like, texting and social media. It’s like, we’re not made for that.

Jen Pfleghaar, DO, ABOIM

I agree and find it interesting because you said that when TH1 gets disrupted, there is more inflammation and more cancer. There’s this whole new turbo cancer thing. It’s like a real thing, and it’s acknowledged. Except no one’s admitting what might be causing this. 

Kent Holtorf, MD

Some thoughts, but it’s multi-factorial. But for myself and how I learned some immune modulation, I was on three and a half years of the highest dose IV antibiotics, like seven at a time, three times a dose that I wouldn’t give patients. It’s too dangerous, and it wouldn’t touch it. I was up in the ICU, and I remember the nurses were making a shift change, and so that Aids patients kept turning up negative for HIV and Savannah, my natural killer cell function was zero. It doesn’t matter how many antibiotics you take; you can’t kill it enough. You have to have an immune system here that takes over.  I had no immune system. Until I fixed that, and then that’s when I got better. I remember I had carotid gland inflammation, and I’m like, just like it was killing me. I went to the EMT, and he said, You got program information, take some antibiotics. I’m like, well, I’m on seven IV antibiotics. What would you suggest? He’s like, looks at me, and just walks out of the room.  

Jen Pfleghaar, DO, ABOIM

That’s a great point. Because a lot of the time, people are like, I have Lyme. I just want to kill it. They have chronic Lyme though, and I’m like, yes, there’s a place to hit it hard with antibiotics, but with chronic Lyme, you have to make sure your immune system is even ready to go. Like is good to go and your gut health. That’s why I love one of the oral peptides, BPC 157 because it can just give you that extra help to get someone who’s sick more balanced before you start attacking the problem.

Kent Holtorf, MD

It’s nice because it works for so many things, and it’s the rejuvenating hormone people think of as a gut hormone or their gut peptide. It heals that gut lining. Everyone has a leaky gut now, which means every brain improves a microbiome, and that gut-brain axis will regenerate nerves and the brain after traumatic brain injury. They cut the sciatic nerves of rats. You can do that with attorneys, too. 

Jen Pfleghaar, DO, ABOIM

With who?

Kent Holtorf, MD

You can do rats or attorneys. Either one. If they’re bathing, one dose of BPC grows together. If it doesn’t, if they don’t, it doesn’t. They just have so many things. Wednesdays are animal studies, but they gave rats with inflammatory bowel disease, and MS. They gave them all oral BPC treated both of them.

Jen Pfleghaar, DO, ABOIM

That’s amazing. You work with a lot of veterans who have a lot of post-traumatic stress disorder. What peptides do you find help with that? Because, like you said, stress is a killer. We ignore it.

Kent Holtorf, MD

People think stress lowers your immunity, but it doesn’t. It modulates that one. It lowers the TH1 but increases the TH2 inflammation. I’m not a veteran, but I just see the care they’re getting. It was just horrible. Our first patient is mom, she is here in the room. She works for us now. But it was a special force on special forces. They found him. He had terrible PTSD, anxiety, and cognitive dysfunction, he had allodynia, where you touch the skin, and it burns so badly. Then they find him face-down essentially pulseless, kidney failure, liver failure, heart failure, and rhabdomyolysis. They said he wasn’t going to make it. He put him in an induced coma and said, he was not going to make it. But they have special forces and he makes it. He had been in and out of the VA, seeing neurologists in and out, and no one was helping him. We’ll see him. Within, let’s see that the first visit we did, we had a we had a bunch of peptides, and we also had like a peptide cream and stuff. He has terrible allodynia. He couldn’t have a sheet or pant leg on his leg and he couldn’t flex his foot. And I’m talking to Gene’s mom at the time, and then I also see the other doctor in my office beating on his leg, and I’m like, “What are you doing?” He’s like, “It doesn’t hurt.” So we didn’t use any narcotics or ketamine or, like, local anesthetics when they came and it went away within like an hour. We got rid of his allodynia right off the bat. 

Over a four-day visit. He couldn’t read a book before, and then he could sit down and read a book. He could function. He could sleep. His life was just; he couldn’t do anything. He couldn’t even sleep and stayed in bed. He was just anxious and nonfunctional. When he went camping. like, either on the fourth visit, when they go camping, they don’t bring a sleeping bag, they don’t, and nothing like when I go camping I stay at a three-star hotel. But it was incredible. then we started seeing more veterans, and I thought they were going to be heterogeneous. They had all these different problems. and so we were covering everything. We were able to do more testing than they would do otherwise. We found out that they all had traumatic brain injury, and PTSD, and they were all disabled. So we found that they had tons of toxins, like huge levels of toxins, again. and normal people due to. But there’s just even, even higher. and they all had chronic Lyme, and, like, how do they get that? I’m looking in Afghanistan; there’s no one there. It’s just like and then, but I found out they were all trained at Fort Bragg in North Carolina, endemic for Lyme and they’ve been lying in the bushes for months. 

They got that before they got all the vaccinations and all the burn pits. If you look at the studies, if you have a chronic infection and toxins, and this was shown in Africa, where people worked in cobalt mines, they wouldn’t get autoimmunity unless they were exposed to malaria. But every single one of them had pains and had antibodies in their brains to norepinephrine receptors, dopamine, and serotonin. And how’s the VA treating them? Giving them antidepressants and psychotics. One of them’s not working there because their receptors are blocked, and about 16 meds a day are putting the gun in their mouth. It’s horrible. All these nonprofits are doing good things, but no one’s getting them better, and their care is just terrible. We saw more and more, and it was very interesting. and they also had their fit guys. They look very fit. Their telomeres were the lowest 2.5% in length. Their biological age was, whereas it was that they were much older. Another study was very interesting because they showed that if someone has a traumatic brain injury, it doesn’t revolve around Lyme, which was interesting, and they had that in the study. But, essentially, without exception, they all got dramatically better. 

Jen Pfleghaar, DO, ABOIM

That’s so amazing. Could you walk us through with these patients what peptides you found to help them? TB4, and probably KBV PDP.

Kent Holtorf, MD

We found that the nice thing about all these conditions is that they all have the same underlying issue. If you look at if they get immune dysfunction, whether it’s from aging your thymus involutes, or if you get stressed,  it makes it worse. Any traumatic brain injury, any emotional stress toxins, and then you get several things happen. You get pineal dysfunction and pineal hypothalamic pituitary hormone dysfunction. They’re often low in hormones, but it doesn’t look like it on a test. Like their thyroid, they’re all of that but their TSH is low normal, and their T4 is high normal. The doctors go, you’re high thyroid. No, that’s low because they have hypothalamic-pituitary dysfunction, low TSH, and low mitochondrial function. The T4 requires energy to get into the cell. It goes up because it’s not getting in. It’s up in the serum. But they also have low free T3 and high reverse T3. That’s how you can differentiate. They all have mitochondria dysfunction, which is a commonality of every chronic illness. They’ll get immune activation of coagulation. So the body will try to lay down fibrin trying to wall off that infection, which in the short run is good. But these bugs, and especially Lyme, have learned to hide in that fiber. They wrap themselves in fibrin, and so the body can’t get at it. It is also a barrier to not only nutrients getting into hormones and medicines but also waste products getting out. An option that normally takes two seconds to get into the cells could take up to two minutes, and we can do a little.

It’s almost like a parlor trick or test, but you can have a party. It’s not perfect because it also depends on motivation, but it’s pretty consistent to just show someone. If you have someone blow out all their air and you get a pulse ox, but hold their breath as long as they can. What will happen is that, as is normal, blood will go from your lungs to the heart and then from the vessels into the cells. That will drop after a minute or two, and it’ll start going down. It’s about 70’s or so. But for people who have this fibrine laid down, it barely budges in because the oxygen is taking so long to diffuse into the cells. Your pulse ox is 98. It’s not because it’s not getting into the cell. They don’t have what we will call air hunger and you give them a little heparin, and all of a sudden they go, Or along with, some of the vascular enzymes, lumbrokinase, nattokinase, bromelain, which also dissolves spike protein too but and also we’d have people that they’re not responding and then we check their coagulation IVs and then after we clean up this coagulation which you can check the markers D-dimer, prothrombin, antithrombin, thrombin-antithrombin complex, prothrombin fragment 1+2. Some things that you can look at, plus we have another coagulation test and, we look at their blood, it looks like chili sometimes, but, and you clean that up and things that didn’t work before, and now start working because they’re getting into the cell and with, the mitochondria dysfunction. We’ll also check everyone’s basal metabolic rate. We’ll check how many calories they burn over 24 hours by basic extrapolation. We find that they’re usually 25 to 40% low. How many calories were burned? If they have no mitochondrial function. They have a low, lower body temperature. and they all have low thyroid.

You have the mitochondrial function you can do on a controlled peptide; you can do T3, but the key with these guys is immune modulation, which we’re finding in almost everything. Whether it’s long COVID, MS, or ALS, we have people in wheelchairs coming. Any autoimmune, Hashimoto’s, you can name any of it, and you got so much immunity first and then, where we’re finding so, like, usually so think of, as the FDA, you and I guess to me, the peptides were safe and effective. They had to ban most of them. But so we lost those injectable immune modulators. But the nice thing is that there’s a replacement. For instance, there’s TB4-frag, Thymosin Beta 4 is an immune modulator and also has a rejuvenating factor. Thymosin Alpha 1, is approved in 38 countries for immune boosting and cancer because it is a booster of TH1, and they banned it as soon as they made the mistake of coming out showing they were safe and effective for COVID right off the bat. If that was safe and effective, they kicked off the vaccines. But then the Thymosin Beta 4 is multi-domain, meaning that they do several different things. It has a domain. The first four amino acids are the monitoring part. There’s a part that binds actin. There’s a part that stimulates mast cells. Then there’s a part of the ages on the other side, which is rejuvenating. So we’ll use the first part and isomer of the first part, which is about a half-life 20 times the half-life of the standard TB4-frag. So it boosts that one. then you get something like BPC will lower TH2 and have a lot of rejuvenating properties, it has multiple effects, and then KPV is the last three amino acids of Alpha1 is a stimulating hormone. It does not stimulate melanocytes. It’s amazingly anti-inflammatory, but it boosts the immune system. We’re having very good luck, two weeks ago or so, this person, in the blog Diary of Recovery. She was a mom, and her son had autism, so she had a blog and a big following. People trusted her, and then she got long-term COVID and KPV changed their lives. Then, all of a sudden, all these other people are taking it, and it’s just, I knew it worked, but it didn’t work that well. If you go to that Diary of Recovery, some very touching case studies on that. It’s also a more potent antifungal than fluconazole at one 1000 per dose. It’s a more potent antibiotic against staff at about 100 times per dose. You’re killing these bugs, lowering the inflammation, and boosting immunity. We use an isomer of that too that’s much more potent and resists breakdown. It’s an amazing study on, autoimmune and psoriasis and, all of those things.

Jen Pfleghaar, DO, ABOIM

It is amazing, especially the long COVID.  I’ve had to go outside the box to get these patients better and the vaccine injury from that. I don’t know, without peptides, how they would be back to work. I’ve had patients that were on disability, and when they came to me, we, well, we removed some root causes, some mold issues, and with peptides, it was just life-changing. It’s frustrating because a lot of the things you’re talking about, people might be listening, and they’re like, Well, I’m just going to go out and ask my doctor about the stuff. But unless you’re going to an integrative or functional physician, they’re probably not going to know what you’re talking about. You have to advocate for your health with these things.

Kent Holtorf, MD

That’s how the world changes—you no longer just listen to your doctor. I tell patients, don’t listen to me. Go check what I do. Ask me any questions. If I can’t answer, go somewhere else. Because. it’s to say if a doctor or some patient will say, My doctor says that he doesn’t know. Stay with that doctor. It’s a doctor’s; the less a doctor knows, the more adamant there. Typically. 

Jen Pfleghaar, DO, ABOIM

I agree, and they never call me back. Like conventional medicine, even though I’m a double-boarded doctor, they don’t call me back. Did they ever call you back? 

Kent Holtorf, MD

The patients, let’s say they’ve been beaten on the patient for ten years and patients are very sick. You get them better and send them back to that doctor. The patient thinks that the doctor is going to be happy.

Jen Pfleghaar, DO, ABOIM

No. They’re mad. 

Kent Holtorf, MD

We had a patient Hurthle cell cancer and a doctor. Like, we got to get this out this week, and then she called me. I said, it’s inflammatory cancer. I just maybe need two to three months, and we’ll see. She decides to do that and tells him she has a death wish. This is crazy. So we did the peptide treatment and we got a scan even earlier than we were going to, and it’s gone. She is so happy and shows her doctors, who have been my friends for 20 years, She goes all happy, running up to show him the scan, and he won’t come out of the back, and he’s told the receptionist to tell her you’re no longer a patient.

Jen Pfleghaar, DO, ABOIM

I don’t know why they’re so scared—maybe something that we weren’t brainwashed with in medical school that pharmacy is the only thing that works. And the big pharmaceutical stuff, why can’t you just realize that maybe you were duped? Sometimes I want my medical school loans, the rest of them that I have left paid off.

Kent Holtorf, MD

Do you have other doctors that work under you?

Jen Pfleghaar, DO, ABOIM

No, Kent. It’s sunny out today, but it’s hard to get people to move to Northwest Ohio.

Kent Holtorf, MD

It’s hard to get people to move to California. 

Jen Pfleghaar, DO, ABOIM

It depends on where. I was looking at this while speaking about toxins in Northwest Ohio. We have so much glyphosate. I tell my patients, well, the area we live in used to have tons of mold. then there with all this glyphosate, and I’m like, I have colleagues, and people just get better faster than here. When I work with people in health coaching from other states, they get better faster. I’m like, we just live in a toxic area. But yes, why is glyphosate still legal?  I have no idea.

Kent Holtorf, MD

I don’t think we have an opening if you want to come to California.

Jen Pfleghaar, DO, ABOIM

That would be a big change. I don’t know how that would work. I’ll think about it. 

Kent Holtorf, MD

Is anyone out there listening, we’re looking. Here’s the problem that we’re finding: our model has been trained by the doctors for like two years, and we can treat pretty much anything. Now the doctors are trained to use this algorithm because they can only do what the insurance company allows. This is what you have put in a box. You get this medication, and they don’t know physiology anymore.

Jen Pfleghaar, DO, ABOIM

I agree because they can’t even think. COVID, made me realize that, like so many doctors, they are just going through the motions. It’s not always their fault. Sometimes it’s because they have to see so many people and have no curiosity.

Kent Holtorf, MD

The incentives are wrong. The doctor who cares the least in the standard model does the best they can.

Jen Pfleghaar, DO, ABOIM

They should give out bonuses not based on whether all of your patients are up to date on all the things that they should do; how many don’t have a chronic disease? Who do you only see once a year for health visits? But we live in a broken system, and that’s why you’re like I said, an original gangster with all of this.

Kent Holtorf, MD

The doctor burnout rate is so high, it’s like 65% of doctors are depressed. They don’t want to work because we’ve given up control. And nine to five, they’re just told what to do. They don’t have any ability; their judgment doesn’t matter. It’s just paperwork, how much they can bill, and how fast they can see a patient. They don’t want to see a complex patient and clog up because they don’t get paid anymore for seeing a patient for long hours than for the hours they spend with a patient. And then you get immediately fired from Kaiser.

Jen Pfleghaar, DO, ABOIM

I’ve had it happen to my friends who are surgeons, and well, they looked for other jobs. They were like, I will not be in this toxicity. I am worth more than this because they were told they had to cut down on the time they talked to their patients. But anyway, we can’t talk about it because we could vent all day or I could. But can you talk a little bit about the different formulations of peptides? The difference between a natural isomer and a regular peptide.

Kent Holtorf, MD

We found that the big problem with oral peptides is that they generally get broken down in the gut. Now there’s BPC 157. The smaller the peptide generally gets less than three amino acids. It’s going to survive in general, or maybe, maybe not. What the body does is that if it wants to protect a peptide or a protein from being broken down in the gut because it’s a critical peptide or protein, it calls with capsid. It acetylates on one side and imitates on the other. It usually puts two caps on it instead of being a salt, and BPC 157 is interesting because it’s 14 amino acids, and it’s so in an aberration that it absorbs so well. But the studies show that every study that’s looked at compared it. The same study used oral acetylated BPC and injectables. It’s been equally potent. It’s worked as well for systemic illness whether you give it a shot or not. I would say that probably isn’t true if you’re injecting into a joint where you’re going to get higher punch rates or something like that. But so the company that had the patent on acetylated BPC, ran out.  So they came out with arginine BPC, and arginine will stabilize peptides in general.

But then they did a study where they put it in gastric juice with a low pH and said that the acetylated broke down and the arginine did not. That flew in the face of numerous third-party studies that BPC acetylated is stable in the gut. That’s where it’s made; they went over 24 hours and numerous times, and it was already stable. But even then, let’s say it wasn’t using a territory capsule. But now the big problem is that when it gets into the gut, arginine dissociates from the salt from the BPC, and now it’s just vulnerable and gets broken down. The people who use it, but then they called it stable BPC. Very good marketing. and most people that supply that they’ll add like a snack to it, which is a substance that breaks open the tight junction so it can absorb, which it helps it absorb, but you use it with people who have leaky guts. You’re trying to fix the tight junctions, and so you’re breaking them down so you can fix them. It’s just a little a little strange. When you when you look at the data. not only captures, but also the body will make certain isomers that they’re the same molecule, but they have a different twist to the amino acid. They’re like mirror images, and the body will have a certain percentage that has that. They tend to be more active and resistant to enzymatic breakdown because they don’t fit with those enzymes, but they’re often much more potent now; certain ones can be less potent. There’s, there’s studies and all those things. Getting the natural isomers can make a big difference, like the TB4-frag at 20 times the half-life. If you look at the graph or the KPD dramatically and much more likely activates it. It will attach the receptor with a much higher affinity and break down much slower.

Jen Pfleghaar, DO, ABOIM

That makes a lot of sense. Because, as you said, we have to move towards more of the oral peptides because a lot of the ones that were subcutaneously are being taken away, which is just ridiculous. 

Kent Holtorf, MD

We’ll see what happens with that. hopefully, change.

Jen Pfleghaar, DO, ABOIM

But for right now, we’re just doing the best we can and pivoting. Now there’s also something about which we talked a little about the summit with other people, bioregulators. There are peptides and there are bioregulators. Bioregulators are those shorter chains of amino acids.

Kent Holtorf, MD

The history is very interesting. In the Soviet Union, they realized that their submariners, their high-speed test pilots, and their astronauts were aging very quickly. So they went to the Soviet Military Gerontology, Khavinson said, “You fix this problem, so you better.” And I don’t know how many things he tried first, but he found that, in particular, he took fetal thymus and pineal gland extract and injected those in these people, and it essentially reversed it. Then they started finding other of these compounds. They didn’t know what they were. They were just extracted and highly purified, and they were only a military secret. They only gave it to the military and the Olympic athletes, and they did pretty well during that time. And so there are numerous ones for, like, almost every tissue. It gets very confusing because they have Russian names and there’s synthetic and natural. But the key ones that he found, the initial ones he found, are the pineal, which the synthetic one would be, epitalon, and the thymus, which would be, thymogen. Oral thymogen is about a hundred times as potent as, injectable thymus.

Then there’s one called vilon with 22 amino acids, and it has a brain aspect and a pineal aspect, and it’s amazing, like the thymogen, the studies on animals and humans dramatic reduction in cancer because, again, it’s raising all TH2, epitalon, lengthening of telomeres. It’s the control of all the hormones, which lowers inflammation, raises melatonin, and sets the circadian rhythm. especially when you take two things, like the epitalon and the thymic peptide, and say thymus, thymogen, and, like the human studies, they found a group of humans over 65 years with significant cardiovascular disease. They gave them six in six doses over 15 years, resulting in a dramatic reduction in cardiovascular disease mortality and morbidity, fewer infections, and higher quality of life. Their cardiovascular system got better, not worse. and there are so many things like that. Now the big thing with these bio-regulators is lowering and reducing the biological age. Now, we can check someone’s biological age based on telomeres, which are the little caps on the chromosomes, and every time it replicates them, they get shorter and shorter. As they get shorter, it messes up cells, or by methylation patterns. There’s a study to be published soon.

They had people; now it’s going to be about three years of different bioregulators, ten days, then rotating them, and they’re losing an average of five years biologically instead of gaining three years, and some are losing 14 years of age. Because the biggest correlation with chronic illness is age. So if you can de-age yourself, and as you de-age that immune system is so much better off, and one thing is for sure: this hit trial came out to rejuvenate the thymus, and they use growth hormone, metformin, and DHEA. But it’s like going through all that hassle like we have thymic peptides that are orally available in the gut. Just it’s like trying to stimulate the testicles that cost it. You can do that, but stimulating the thymus is a little bit more difficult. But we give testosterone for that, or we give estrogen. So just keep the thymic peptide, and if you combine the epitalon and the thymus, it’s probably the number one anti-aging thing that you could do.

Jen Pfleghaar, DO, ABOIM

It’s so exciting what we can do. You just need a good guide to walk you through this stuff. 

Kent Holtorf, MD

You’re so safe, too.

Jen Pfleghaar, DO, ABOIM

I want to end with you talking about the mold, the illness, and the whole trials update book that you wrote, and maybe some little pearls you can give us from that.

Kent Holtorf, MD

With SIRS, it’s also like. all of you with chronic fatigue syndrome and chronic Lyme.  Most people have SIRS Systemic Inflammatory Response Syndrome. It’s essentially people who think it’s mold, but it’s toxins. Toxins, along with an infection, cause all this immune dysfunction. and so Shoemaker has done so much for this area that it’s just incredible. But I looked at his program, and I had so many people coming in, and they’ve been sick for like eight years, ten years. But they’re like, “I know I’m gonna get better. I’m on these binders.” The mechanism of his protocol is to get rid of the mycotoxins. then that once you get rid of them, that will fix the immune system. But with a low immune system, you have inflammation; with a dysfunctional immune system, you have mitochondrial dysfunction. You can’t detox with an immune system like that. Why don’t we easily go after the immune system first and then add all these different areas or whatever is wrong? Let’s say it’s, epitalon, mitochondrial peptides, the kidney peptide I love because I had chronic kidney disease secondary to Lyme, Bartonella, and just totally reversed that.

But you fix the immune system first. But that’s a pinnacle, of his. So he’s trying to fix the immune system by getting rid of the toxin. But you can also get BPC 157 and other peptides that protect the body from toxins and fix the immune system. Now their mitochondrial systems are better. They get rid of the toxins and the heavy metals, and all of a sudden everything just starts coming back. So you don’t have to just try to get rid of all the mycotoxins that you are getting; so many people are getting so many other toxins. It reverses that whole thing. We find you can get people from A to B in months rather than years.

Jen Pfleghaar, DO, ABOIM

That makes a lot of sense. Those people are looking to recover quicker because they feel like such garbage. They can’t even get through their day.

Kent Holtorf, MD

We’ll have that available as a bonus gift.

Jen Pfleghaar, DO, ABOIM

That’s awesome. Thank you so much, Dr. Holtorf, for sharing your knowledge, your expertise, and being so passionate about what you do. We need it. We need a hundred million more doctors like you. Just being as passionate as you are. Tell everyone where they could work with you and where they can find integrative peptides.

Kent Holtorf, MD

We have about 20 new products scheduled to come out, which will be combinations of peptides, and bioregulators. The first one is a cognitive one, which is the brain bioregulator, the pineal, and the vascular. The vascular system is amazing because, with all of this, cardiovascular disease even brain disease. The lining of the vessels is inflamed, and that’s why it reduces that, and the studies are amazing. We have reversed cardiovascular disease, and cognitive dysfunction in pretty much everything. One has the cortex, which is the brain, the pineal, and the vilon. Then also a cerebral revelation, which is the brain peptides in the pineal, has the epitalon. Then we have a thyroid irregularity coming out. The problem with the natural ones is that they’re expensive. You have to extract those. We had some natural-made BPC from the pig gut. The company even said we would never do this again. It’s so expensive but we have it, so we can put it together. We’re going to have like three or four bioregulators together, and we’ll be able to sell them for the price of the natural. But we also do both. It’s very exciting with that. We’ve integrative peptides. We also have peptides coming out for pets. We have so many heartwarming stories with pets, which is cool. People like, humans; they’re probably jerks anyway, but animals and people will care about their animals more than they do themselves. So, that’s one of the few biological vets on board. We’re going to be doing clinical studies and all that. We’re looking forward to that. a lot of stuff in the pipeline.

Jen Pfleghaar, DO, ABOIM

Awesome. That is so exciting. I’m so excited about the new products.

Kent Holtorf, MD

And I forgot to mention that we’re also starting a year-long training.

Jen Pfleghaar, DO, ABOIM

That’s great.  Is anyone listening out there who’s a practitioner? If you want to learn how to use peptides, that would be a great course for you.

Kent Holtorf, MD

Or if you want a job.

Jen Pfleghaar, DO, ABOIM

Yes, exactly. awesome.  Thank you so much. It was great talking to you, as always.

Kent Holtorf, MD

Great. Thanks so much. great job with the summit, it’s something I’m looking forward to. Thank you.