Why Exercise May Be More Powerful Than Any Alzheimer’s Drug

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Dr. Perlmutter’s groundbreaking new book, Brain Defenders, is now available for pre-order. Discover how to protect your brain and future health – reserve your copy today at https://www.braindefenders.com.
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If you’ve followed my work for any length of time, you know that one of the central themes we return to on The Empowering Neurologist is this: your brain is far more adaptable, resilient, and improvable than conventional wisdom ever allowed us to believe.

This week, I’m thrilled to share a conversation with someone who has spent more than three decades proving exactly that. Dr. Majid Fotuhi, neurologist, neuroscientist, Harvard- and Johns Hopkins-trained physician, and now author of the new book The Invincible Brain, has dedicated his career to helping people reclaim their cognitive potential. His message aligns powerfully with the philosophy behind  my upcoming book, Brain Defenders: that the trajectory of your brain is not predetermined, and that meaningful change is possible at any age.

In our interview, we explore the groundbreaking ideas that shaped The Invincible Brain. Dr. Fotuhi lays out why intelligence is not fixed, how memory can be strengthened through surprisingly simple practices, and why Alzheimer’s disease is not the single, linear condition we once imagined, but rather a complex “soup” of abnormalities with multiple entry points for intervention.

This is an inspiring, practical, deeply insightful episode. I hope you’ll join us for this important conversation on how to build a brain that is stronger, sharper, and truly invincible.

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00:00 Intro
01:44 Choices influencing brain trajectory and resilience
04:25 Redefining intelligence beyond IQ
08:20 Synergy of memory and habit change
13:09 Challenging genetic determinism with epigenetics
18:00 Ad Break: Optoceutics
20:23 Alzheimer’s as a metabolic and inflammatory soup
29:45 Ad Break: Fresh Pressed Olive Oil
38:04 Exercise and metabolism in brain health
43:45 Ad Break: 3×4 Genetics
49:38 Brain training and five pillars of brain health
54:55 Mindset as key to becoming a superager
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Dr. Majid Fotuhi earned his PhD in Neuroscience from Johns Hopkins University in 1992 and his Medical Degree from Harvard Medical School in 1997. Currently, he serves as an adjunct professor at the Mind/Brain Institute at Johns Hopkins University, while also teaching at George Washington University and Harvard Medical School. With 37 years of experience in teaching, clinical practice, and neuroscience research, Dr. Fotuhi has pioneered a multidisciplinary approach to enhancing brain vitality and cognitive performance at any age.

His groundbreaking “Brain Fitness Program” combines a comprehensive baseline “Brain Portfolio” assessment with 12 bi-weekly brain training sessions. This program targets lifestyle optimization and cognitive stimulation to improve memory, focus, and overall brain health. Dr. Fotuhi’s program has delivered measurable success for patients dealing with memory loss due to aging, concussions, and ADHD, as documented in several peer-reviewed journals.

He is also the author of three books, including the highly acclaimed Boost Your Brain: The New Art and Science Behind Enhanced Brain Performance. Recognized as one of the leading experts in memory and successful aging, Dr. Fotuhi has delivered lectures at academic institutions and major organizations in over 20 countries – including a TEDx presentation in the Philippines. Passionate about sharing the latest discoveries in the field of brain rehabilitation and neuroplasticity, he has been featured in interviews with more than 50 prominent media outlets in the United States and around the globe.

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