Photodynamic Therapy: Explore This Innovative Cancer Treatment

Michael Weber, MD

Thank you for inviting me.

Michael Karlfeldt, ND, PhD

Yes. I just want to let everyone know that Dr. Weber is somebody who is leading the field of photodynamic therapy or photobiomodulation. He truly is a pioneer of modern laser therapy. There are a lot of people, I would not say a lot of people, but there are some people who do the research at the honor university level. But to bring it into the practical and clinical aspects, Dr. Weber is leading the field in the world for that. Dr. Weber has been working on, say, just a little bit about the background. Dr. Weber has been working as a medical director in Germany for more than 20 years. Is it 30 or 40?

Michael Weber, MD

33.

Michael Karlfeldt, ND, PhD

Yes. Today, he manages three medical centers for general and internal medicine, pain therapy and naturopathy, acupuncture, and photodynamic tumor therapy. Besides his medical degrees, Dr. Weber holds a Diploma in Biochemistry, which made him a decisive contributor to the research and development of new laser technology. As president of the International Society for Medical Laser Applications and coeditor of several international medical journals, his focus is on research and the publication of new methods. For this purpose, Dr. Weber collaborates with numerous international institutions and universities. The patented Weber needle technology, which I use in my clinic and which was developed by Dr. Weber himself, allows us to apply highly focused and efficient lasers of different wavelengths for the benefit of our patients’ health. Well, this is the technology that I feel is the future of medicine: using light to impact the body and change cellular function, as well as going after things that we do not want to have there, such as viruses, pathogens, tumors, etc. This is going to be an exciting conversation.

Michael Weber, MD

Okay.

Michael Karlfeldt, ND, PhD

Tell me a little bit about modern laser technology and what it can do for the body. I know that that is a very broad question. But if you can just give a little bit of an overview of what laser technology can do for a human being,

Michael Weber, MD

There have been lasers on the market for maybe 30 or 40 years already, and the first lasers were already developed in the 1970s in Hungary. They used lasers first for stimulation of wound healing; for example, some years later, lasers were used for treatment, for pain, to improve muscle spasms, microcirculation, and everything else. But when people hear something about lasers, they always think of surgical lasers. What is used in surgery could be an insert to cut the tissue and regulate the tissue. Of course, there are many lasers on the market for those purposes: surgery, dermatology, and ophthalmology. A lot of these are so-called hard lasers and strong lasers. They are completely different from what we are doing. First of all, we have to distinguish between the strong, hard lasers with which we can destroy the tissue and the so-called low-power or low-level lasers, which have a more healing effect on the body. These lasers bring energy into the body, and the energy is used for the body, for regeneration, for regeneration of the mitochondria, to give more energy, so it is used for healing, not for the destruction of anything. We know today that lasers have a lot of benefits for the body, especially low-level lasers. They have been widely used in the last ten, 20, or 30 years, not only for wound healing but for so many things in dermatology, including organs, and what is very important are also new colors and wavelengths.

In the beginning, 20 years ago, we had only red lasers in the infrared. But now we have the full spectrum of colors. We have blue, green, and yellow ultraviolet. With this kind of laser, we can stimulate a lot of healing and energizing processes in the body. The main source of our life energy is in the mitochondria, where we produce our life energy. We know today that the different molecules or complexes in the mitochondria are so-called chromophores because they were developed over millions of years in the solar spectrum. We know today that, especially in the mitochondria, when we bring the light inside the mitochondria, we can increase a lot of energy in the body, the so-called ATP, or what our normal life energy is, and therefore we need the special colors because the different chromosomes have different absorption spectra. If you compare, for example, the chlorophyll in nature in green plants, they absorb the red and blue light from the sun. In the mitochondria, we can see that we need all different colors.

However, the problem still is that light has to go into the body. But unfortunately, and there are many devices on the market for that when you bring to light only from the surface and the body, it will not penetrate deeply enough, especially the wonderful short wavelength blue or green. What we have developed are new devices with which we can bring the light deeper into the body, ideally anywhere, so we can bring it directly into the bloodstream using specific steroid catheters. We can bring it with so-called fiber optics. There are needles deep in the spine to regenerate spinal problems. We can bring it everywhere in the body today. That is a new development from the last 20 years. The regenerative effects on the body are called photobiomodulation. That means we give light and induce biomodulation. But mainly, it is the modulation of the mitochondria that provides the whole body with low-level light. It is a regenerative tool for our body for many, many healing purposes, and we want to increase the power of the cells. 

We want to induce healing regenerative processes through the regenerative effects of lasers, which we call photobiomodulation. However, we can also use the same light not for regeneration but for the destruction of the bad cells in the body; cancer cells, bacteria, viruses, etc. are not phototherapy. We call it photodynamic therapy because we induce dynamics in the body. But this works only if we combine the laser light with the photoactive substance, as I told you. Already,  we have chlorophyll in nature, and we have similar products. What we can bring into the body, maybe on the skin, or inject into the body is that those substances can bind to malignant cells, for example, tumor cells, but also bacteria, viruses, fungi, and other microbes, making them light-sensitive. When we then give the right light according to the absorption spectrum of the substance, we can induce the production of reactive oxygen radicals, which can then kill cancer cells or microbes. That is different from what we always have to keep in mind. We have phototherapy for regeneration, and we have photodynamic therapy for the treatment of cancer or bad infections. That is something we have developed in the last 20 years. We have gained a lot of experience today. We are happy that we have different photosensors. We have derivatives from chlorophyll; we call them chlorins. We have derivatives from the hair molecule; we call them hematoporphyrin. We have other natural substances: curcumin and riboflavin; which is vitamin B2. Hypericin is from the St. John’s Wort plant. There are a lot of different substances that we can use in photodynamic therapy.

Michael Karlfeldt, ND, PhD

Tell me a little bit about what does a photosensitizer do?  Do you take that orally in a pill, or you get it intravenously, or you can inject it directly around a tumor site? What is it, how does it get into the tumor, and what does it do in the body and to the tumors?

Michael Weber, MD

Yes. There are different options. Mostly the photosensitizer, especially somebody who has deep-seated cancer in the body. We have to inject it, and we have to give it into the bloodstream. That is also an interesting option because we know that later metastasis, which can develop from cancer, comes from circulating tumor cells in the bloodstream, or maybe so-called tumor stem cells. What we are doing, is we give the photosensitize that we inject them, and then it is in circulation for a certain time, and then we can irradiate the blood, and if there are some circulating tumor cells in the bloodstream, we can destroy them and clean the blood first with so-called intravenous laser therapy with the right wavelength. According to the absorption spectrum of the photosensitizer. If we use, for example, curcumin, we need blue light. If we use vitamin B2 or riboflavin, we also need blue light. For hypericin, we use yellow light. For chlorophyll derivatives, we would use red light so we could apply all the different lasers. Fortunately, we have set up the new devices with the full spectrum of light so that we can use them for all different substances. But when you ask me what is happening, first of all, it is in the bloodstream, and then it takes only a certain time. It depends some photosensitizers need 3 hours others, 10 hours or one day or so they can enter into the tumor cells.

There are different mechanisms by which they can enter the tumor cells. We know, for example, that chlorophyll derivatives mainly bind to higher-expressed LDL receptors. There is receptor binding, which then brings the substance into the tumor cell. There are different options. For example, the different photosensitizers, for example, Indocyanine green. We use them in nanoparticles, liposomes, or micelles. We know that the capillaries in the tumor are different from the normal capillaries. They have gaps inside small holes so that the bigger particles can enter through the tumor cells but not in the healthy tissue. We must have no side effects on healthy tissue. We call it the EPR effect. This is an enhanced penetration and retention effect. Another option is that there are different ways to induce causes of active transport into the tumor cell, but once these photosensitizers are in the cell, we can irradiate and destroy the cell by using the right light. The most interesting thing and this is just two years after anemone therapy from chemotherapy, is that chemo and PDT photodynamic therapy both have the same effect of killing tumor cells alone.

But that chemotherapy also kills our immune system, and that is exactly what we need for the treatment: when you use photodynamic therapy and you request the cells and the damaged materials, then the body can take up the macrophages. For example, this material will lead to dendritic cells producing antigens, and they will connect with specific T cells and activate them so that the T cells have enough of a secondary effect on the tumor and also maybe on the metastases, which are somewhere out in the body. That is the most interesting thing about photodynamic therapy, which stimulates the immune system, and that is the difference from chemotherapy. Today we just discussed it. It is a very interesting approach, maybe to combine photodynamic therapy with different immunotherapies.

Michael Karlfeldt, ND, PhD

Yes, to me, that is just the fascinating component because when it is so, it works as a vaccine, but it is not a vaccine that you have formulated based on what you think is there or based upon what was there three months ago. It is a vaccine that is formulated based on what is in the body at that moment. then you activate the immune system to make it stronger and be able to be more intelligent. Then it looks at all these fragments of the tumor that you kill, and then it can produce the appropriate antigens and the appropriate antibody response, and then go and hunt the rest of the body for whatever that is.

Michael Weber, MD

Exactly. That is why an auto-immune vaccine is so important. What we are producing is an amazing idea. Maybe we can enhance this process by adding some modern immunotherapeutics, which we normally use to activate T-cells or to prevent the inactivation of the different T-cells. What about the checkpoint inhibitors, for example? What we use anyway is used in normal cancer therapy, and that is a wonderful combination, and that is something we are doing a lot of research on at the moment, so if we can maybe improve the reaction and enhance everything by combination with special immunotherapy, and this is also something else, what we have to consider is that we can stimulate, of course, the photosensitizers, which binds to the tumor cells or maybe microbes with the appropriate light or laser light. But we can also stimulate this with autism in general, and we call it sonodynamic therapy because, most of all, it is a subset of photosensitizers that are not only photosensitized; it is sound-sensitized. We can activate them with light and with ultrasound, and maybe with one megahertz, they can deeply penetrate the body, go through the bones, and even into the brain.

So this is a wonderful combination, and the effect is very similar. We also produce oxygen radicals, but we also produce so-called microbubbles, which then let the cells explode. That is the modern combination, what we are working on, and that is the new therapy. Another key is that we need enough oxygen in the body. I think everybody knows that tumor cells can live and grow without oxygen. They have different metabolisms for glucose, and we have to make sure that we have enough oxygen in the body. We give people oxygen for breathing during the treatment. We put them in the hyperbaric chamber, or there is also a new protocol that we can mix hydrogen peroxide with hyaluronic acid and inject that directly into the tumor. Anyway, what you asked me before is that we can give the photosensitizer maybe externally, as a cream on the skin has been on the market for a long time, our clinic can inject it into the body to go deeper, and we can also inject it directly into the tumor. Yes. The good thing is that we have developed this invasive laser technology device, and it is still the only one on the market in the world with which we can use ultrasound-guided long needles of any size to go deeply into the body to stimulate maybe the product in the pancreas or on the kidney, something we never can do from outside. That is the new technology that we have developed in Germany.

Michael Karlfeldt, ND, PhD

It is so exciting. When you bring in that to photosensitizer just to clarify the point a little bit, when you do the photosensitizer intravenously or orally, it then accumulates, preferably into the tumors because of the vascularity that exists and because they have holes in the blood vessels so then it accumulates more in the tumor tissue. I also heard somewhere that it was about 50 times more likely to enter tumor tissue than healthy cells. Then, because the photosensitizer was there, that tissue became very sensitive to the light that you shine on it. Then when you shine that light on it and you have oxygen in that tissue, it causes it to oxidize, which is chemo’s oxidizing therapy, but this becomes an oxidizing therapy that is very targeted and does not impact a lot of the other healthy cells. It will impact some, but not to the same extent as chemotherapy.

Michael Weber, MD

I think that is a good development from the last few years to make the photosensitizer more specific, that it only completely goes into tumor cells and not into healthy cells. For example, there is one substance that is still approved on the U.S. market, the so-called photo-free nano, and I used it many years ago, but I never liked it because a lot of the substance also binds to healthy tissue. You have always had to expect collateral damage, and it also makes the skin so light-sensitive that people have to stay for weeks in the darkroom after this. The new chlorine e6, or maybe the so-called indocyanine green. They are very specific. then maybe there is still a little bit of light sensitivity for a day or so. But we do not have these problems anymore. That is also a good development from the last few years.

Michael Karlfeldt, ND, PhD

So in the market, when you think of laser therapy, you see people out there with red and infrared, mostly. But the beauty you mentioned is that you brought out the full spectrum of it, and we recognize that we are living in life, we are born in light, we develop in life and mitochondria are the bacteria that existed in light. So it makes sense that we need the full spectrum. We need the whole sunlight spectrum, not just the red infrared. There are then other effects, and let us say we just step away from the photodynamic; there are other effects and other frequencies on the body that can be regenerative and restorative for the mitochondria and other things as well.

Michael Weber, MD

Exactly. That is right. As you said, we are always to think that we are made from everything; every cell in our body is developed into the sun spectrum. Everything in the body will absorb something in the spectrum and use it. We can especially see it in the mitochondria, and we know the different complexes where we metabolize glucose and produce ATP, our life energy. We see that the different complexes absorb the light from the sun’s spectrum. This makes a lot of sense because they are all developed into a certain spectrum, and many people work on stem cells today and want to push the stem cells to grow. We speak about regenerative medicine, and it is the same thing. That this therapy or these regenerative therapies are working. We have to bring the right light energy directly into the cells in the body. Not only red or infrared light shines on the skin to induce all the sweat-regenerative processes. So that is the other. We can, and that is a good thing. We can use all these different spectral colors for maximum regeneration. Is it stem cells or platelet-rich plasma? What we are doing today for regeneration objectively in joints or on the spinal something. On the other hand, we can use all the different colors from the spectrum to stimulate the different photosensitizers for the destruction of malignant or other bad cells in the body, and that is a good thing. We can use it in both ways. 

Michael Karlfeldt, ND, PhD

It is, and as we are understanding it more, we are using it clinically, and you are seeing more and more of the effect, and that is what is so exciting about it. Tell me a little bit about the green and the red and the different effects that they have on stem cells. You brought up stem cells, we all know that we want to live longer, and our brains want to function longer. The healthier the tissue we have, the less likely we are to get cancer. Healthy stem cells become important. I know that people understand that one spectrum or one part of the spectrum has one effect, and another part of the spectrum has another effect, and they are very complementary. Tell me about green and red and how they are complementary to stem cells.

Michael Weber, MD

Yes. Stem cell therapy has also been done for many years, and if you look in the literature, sometimes the results are good, sometimes not. It is very different. Now, more and more in the last few years, you can find new publications and research about laser-stimulated stem cells and what the lasers are doing when you make stem cells. Maybe you will use cord stem cells, for example. We prefer autologous stem cells. What we normally perform on the fatty tissue, so-called adipose-derived stem cells, never has a side effect because it is your material. We inject them into the blood, or we inject them into a joint on the spine or something. Then we hope that they will survive there and grow and maybe differentiate in your tissue, or if they show muscle tissue, but this is a very energized process. We want the stem cells first to survive to grow, proliferate, and differentiate; these are all energizing processes. We have supplied them with enough energy to believe that this therapy is working, and the best energy is light because they have a lot of mitochondria, and the mitochondria deliver the energy that they need to grow so we can use the light that we are today bringing outside and everywhere inside the body to give them the energy they need and make the therapy successful. You asked me about the green light. Red and infrared have a long history, as has green light. We know that green light improves oxygen supply anyway.

You can compare it with the green plants outside, which produce oxygen, and it is easy to keep in mind. The hemoglobin can carry more oxygen. Blue light itself affects killing bacteria, but blue light can also enhance the microcirculation a lot because it can deliver free nitric oxide. What we produce in the body during walking, not nitric oxide, is normally bound to have more hemoglobin, but when irritated with blue light, it immediately opens up the microcirculation. They also have a yellow light, which is quite new, and yellow has a huge anti-inflammatory effect on the body. We also now have UV light, which can kill microorganisms, and maybe metastases in the body. But the key is the general effect of the different light when we give it to the tissue or the blood. But the key for me is always the mitochondria. Today, mitochondria and therapy are the best things. When we speak about anti-aging, as you said, everybody wants to live longer and would pay billions for five more years and a good quality of life. When we look for different complexes in the mitochondria, they absorb the different colors of the sun spectrum. Red, and infrared, as we have known for a long time and new research from the last two years in the Stem Cell Center at the University of Johannesburg in South Africa, can show on the one hand, red infrared enhances the proliferation of the stem cells, but the green enhances the differentiation of the stem cells.

There is only one way, and there is not enough research about blue. But I know that next time we will also find that the other colors also work similarly. The key is the mitochondria. The mitochondria, determine the end of our life expectations because we call mitochondria factories with limited lifetimes, and in all mitochondria cells we have a lot of mutations in the mitochondrial DNA, and then the mitochondrial function will go down at the end they will die, and at the end, we will die. The key is to keep the mitochondria, especially in general, but also especially for stem cells, and I am sure that in the next few years we can do a lot in this field and write new research work that we can improve. Also, using, for example, intravenous laser therapy to enhance growth factors in the bloodstream cytokines, we can even enlarge the telomeres, the telomeres that are the small tails of our genes. What determined their breaking down step by step during our lives is that when you are born with short telomeres, you die early. with long telomeres from your parents, you live longer. We have new data that maybe the telomeres, first of all, will not break down so quickly, especially blue light nitric oxide, is doing this. But we have also seen that they can even go longer. Again, it is amazing data, and that is what we are following up on now in the next studies, which is what we are just initiating here. 

Michael Karlfeldt, ND, PhD

That is also fascinating, as we are talking about the two aspects of photobiomodulation, which is a regenerative aspect, and photodynamic therapy, which is more of the destructive way we go after things that we do not want. We then bring in photosensitive disorders to be able to be more targeted and more effective and reach the target tissue more efficiently. But then, going back to regenerative medicine, we have stem cells; we have people do PRP; we do it at our center; and we have stem cells. Then combine that with other factors like light to make them more effective, give them more energy to be able to, and also be able to use differentiate better light. I apologize for jumping back and forth, but I am doing that because I want people to feel how you distinguish between the two. The photobiomodulation and photodynamic therapy and how light benefits both. Let us go back to photodynamic therapy. With that, the key, as we mentioned, is using photosensitizers.

What are some you mentioned in some photosensitizers: curcumin, riboflavin, which is vitamin B2, and chlorine have ICG in the nano-nized form, which I know is a later development, and 5-ALAs are the newer ones that are out. I would not say out on the market, but because it seems you are the one that is driving, even though there is a lot of research and clinical applications of it, it seems you are the one driving that. Is there anything new on the market that is exciting and has a promise?

Michael Weber, MD

Now, what was new in the last two or three years, first of all, the 5-ALA is 5-Aminolevulinic Acid. This is a top substance that is produced in our own body in the cells, and normally some molecules are put together step by step and they will form at the end of porphyrin, which then gets iron and heme. The 5-aminolevulinic acid is the basic molecule for setting up our heme for the hemoglobin, so it is a natural substance. The key is that cancer cells, for example, cannot metabolize the heme to the 5-ALA because of the step where iron is integrated into the porphyrin molecule that picks up oxygen in the blood. This enzyme is not working, so it will lead to an accumulation of the precursor of the heme; we call it the Protoporphyrin IX. What we are doing today is that we now have available 5-ALA as a drinking solution, and you can drink it, and then it will accumulate in the tumor cell, but differently. We know that different carriers bring in the tumor. So and then in the tumor cell, it will accumulate, but it cannot metabolize to hemoglobin because this enzyme, which puts iron inside, is not working in the tumor cell. That is a big advantage. We have a great accumulation, which makes the cancer cells extremely light-sensitive. Then we can stimulate with red light which has been used for a long time by neurosurgeons, for example. We always, before they make the head, evolve, or remove a brain tumor, let the people drink it. Then that can irritate the open brain with the blue light see exactly red fluid is a sense because you can also lose photodynamics for diagnostics. We call it PDD, photodynamic diagnostic, and you can make it the therapy; we call it PDT for photodynamic therapy. But they used it only for diagnostic purposes, not for therapy. But now there are already new publications, and they are doing the same thing. 

What we have already been doing for seven years now is putting some interstitial needles in the brain tumors and stimulating them with red light to destroy the tumor lots of effort in photodynamic therapy. Another thing is that we just spoke about it. There is a new development at the university in Rotterdam, the Netherlands. They have set up a new combination of different chlorine and the other substance, porphyrin, and this should be extremely effective. Also, it is now available as a capsule. That is the next step of research—what we can hopefully do together, you and maybe some other centers in America. I have great hope that we can because, in photodynamic therapy, when you look in the literature, you will find thousands of publications. This is not an alternative. Always an alternative therapy—vitamin C infusions or something that is not bad, but this is something that is not accepted in the medical world.

But photodynamic therapy is done in many big universities worldwide because, everywhere you can read it, it is the best cancer therapy. After all, as we spoke about, it causes cancer and stimulates the immune system. However, you can read everywhere; there are limitations. The limitations are that we don’t have all the different laser lights, and we are not able to bring the laser light deeply into the body to bring it to a sufficient concentration to stimulate the sensitizer in the tumor and that is exactly what we have developed. With the invasive technology that we can bring, which every color that can even not penetrate all the skin close to or directly inside the tumor, we have to develop all this equipment. That is the biggest invention from the last few years, I think. that can bring us extremely far forward. I have great hope, and it is always step-by-step. Cancer therapies complicate the best researchers who have been working on cancer for 50 years, and we still don’t have a cure for everyone. But this can be a very important tool. I am working on that because I believe in it because I am a practitioner, and similar to you, I see it in my patients and do not have any more experiments in the laboratory. We have the patients, and we can see exactly in each patient with so many different tumors what is working and what is not working. That is the big challenge for the next few years: getting it more specific and successful.

Michael Karlfeldt, ND, PhD

Yes. As you mentioned, we have not figured out the riddle of cancer yet. But all the failures that we have—those are the ones that drive us to push further. But having said that, all the successes that we have make it exciting and make us want to push further. For instance, a patient came in just a few months ago, dealing with metastatic cancer in the liver, gallbladder, etc. Yes, and also another patient; at the same time, you are all over the bone marrow. They were told that they were not going to live for another month, but they were still around and doing well. Yes, they come in not looking very good, not having energy, and they are in extreme pain and cannot move around. 

Now, they are back to work and living and enjoying life, but they lack the energy that they want, and that was because they could not do any chemotherapy, so this was the only option. So, those are the exciting things that make you feel like you are on the right track. But we have not, we cannot, and we have not figured out all the solutions, so that does not mean that we can; we have figured out how to help everybody. But at least this is a big part of the puzzle. Tell me a little bit about some of your experiences, what you have seen with cancer patients and the benefits, and what you experienced because you are treating so many people with some of the most severe cancers that have failed in the medical field.

Michael Weber, MD

First of all, again, I want to emphasize that I am not completely against chemotherapy. People must know that we are normal medical doctors and that sometimes we need chemotherapy, or maybe we should use chemotherapy in the beginning to reduce the tumor burden in the body or not. We also know that in some cases, leukemia, Hodgkin’s, lymphoma, or something else can be very helpful. Sometimes I use chemo myself, mostly in a low dose because chemo drugs can also work as photosensitizers, as we call them, chemo sensitizers. We can make them even stronger with light, but reduce the dose now. I have not completed it. Sometimes I have patients; who have chemo, and sometimes in between, they come to me, and we let PDT know. In some cases, it is really necessary, and I don’t want to say we have a wonderful life; we don’t need all this. We can cure everybody with photodynamic therapy. Cancer treatment is complicated; we know this, and we also always have to combine different things because we are not treating only the disease. We always have to treat the whole person, and we call it individualized therapy. We may have to use a special diet. Psychology is very important. Also, there are some alternative things, like vitamin C or minerals, or there are different things, and they can be very helpful.

I think you are also using different things, individualized for each person. But anyway, the PDT is the main thing, and what we have seen, for example, is exactly what you said. Sometimes the patients there in Germany say, “Aus der therapie” that is, you are out of therapy. Now the oncologists say you have everything and go home and take pain medication, and then we cannot do anything. We always get patients like this. Of course, these are the most complicated patients. When I get a patient with a small node in the breast and nothing else in the body, this is not difficult to treat. The success rate is very high with photodynamic therapy. Unfortunately, we get patients with bone metastases and lung and everywhere, sometimes in the body. But anyway, we have always seen patients do amazing things. I remember one patient with breast cancer lung metastasis and hip joint metastasis, and, of course, we can use the different lasers now; we can put needles on the hip joint. For the lung, we can use special fiber optics to know what the people can and what we can put in the bunker system using an endoscope. But in the easiest case, you can also swallow the fiber optics and irradiate the lung from the esophagus. This is very effective, and there are always patients for whom we have amazing results. However, I want to emphasize that we should not expect that we can cure everyone quickly. But if we are able, if we can give patients maybe a year or two years or more life, and the great thing is with good life quality, and this therapy leads to good life quality. Maybe with chemo, we can do the same thing now, but bad life quality is not enough.

That is the most important thing. When I remember a lot of hopeless cases, especially when they have metastases in the brain, you cannot do anything normally. But now we have indocyanine green that can enter the brain. We have helmets with infrared lights that can go into the brain. We have ultrasound, which we can use on the bones and also on the brain. We do occasionally see process stabilization. The patients can still live and enjoy their lives. We always see this, but not always. But anyway, what I can say in general is that most of the patients, or nearly all of the patients, who have improved their quality of life, feel more energized, can eat better, can move better, and because the laser also provides energy, of course, to the body, as we spoke about before, I think that is a huge advantage for the patients.

Michael Karlfeldt, ND, PhD

You have clinics—yours and mine—that people can go to. In addition to that, people can utilize natural photosensitizers or a laser watch that I know that you develop so that people post-treatment, or if they do not have access to a center they can incorporate and receive a tremendous amount of benefits where you can then have a laser watch and treat the blood as it passes by here, so whatever cancer cells or whatever pathogens, whatever it is, will then be impacted as it is passing by and just circulating.

Michael Weber, MD

Yes, that is the main thing when people stay one or two weeks in our clinic and then they go home, and then they ask me, Well, what else can be done when the therapies are finished? Or can we not do anything at home? Of course, the good thing is that many of the photosensitizers who do not want to use curcumin, riboflavin, or chlorophyll this is available orally as capsules. People can take it home without any side effects. You can, and they are not expensive. Then, one hour after absorption, they can use, for example, the laser watch and then irradiate the blood, stimulating the immune cells in the blood. When the cancer cells are circulating on the stem cells, they bind to the photosensitizers. You can clean all the time to prevent the development of new metastases, as well as the laser. What you give into the bloodstream is energizing the blood and has better microcirculation and oxygenation, as we spoke before.

The post-treatment, and people who have a brain issue after the treatment can still use the helmet for stimulation because the infrared blood can penetrate a certain amount in the brain. What I am also doing may be interesting for you. There are quite cheap ultrasound devices on the market. What a now give the patient that takes home and they can take the pills because they don’t have the fiber optics needle that they can put in the body, but the one that makes it a solar device that can go 20, 30 centimeters. Now they will take home a solar device so they can treat themselves not only with the watch but also with the home solar therapy. Also, this is a very good step forward. I have heard from several patients in the last few weeks that they are enthusiastic about the success rate, and that is also something, and it is not expensive. You can rarely sell them for three or four hundred Euros, which is not a lot of money.

Michael Karlfeldt, ND, PhD

Yes, that is what is so exciting about this field—how it is evolving so quickly and how much research has been done all over the world about photodynamic and photobiomodulation. It is so exciting. Well, Dr. Weber, thank you so much for everything that you are doing to drive this technology forward and to make it available to people in a form that has never been available before. Thank you so much.

Michael Weber, MD

Thank you so much for the invitation to this interview, and yes, I am looking forward to great cooperation with you and some other colleagues in the future, I am sure we could move a lot of things forward for our patients.

Michael Karlfeldt, ND, PhD

Wonderful. Thank you.

Michael Weber, MD

Okay. Thank you. Okay, bye.