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The Genetics of GLP-1s: Why Two People on the Same Dose Get Different Results
Which medication, not just whether to medicate, may be a genetic question. The GLP1R gene encodes the receptor semaglutide binds to, so a less functional receptor means the drug has less to work with. Tirzepatide adds a second target, GIPR, and variants there shape how well that second mechanism lands. Dr. Gibson's point is that most prescribing today is driven by availability and insurance when the panel may have something useful to say first. "GLP-1 medications don't selectively burn fat." I asked Dr. Gibson to say that twice because people still don't believe it. Research shows a meaningful share of the weight lost on these medications is lean mass, and it gets worse without deliberate protein intake and resistance training. Variants in TRHR and IGF2 influence how well someone holds onto muscle in a caloric deficit, which is a conversation that belongs before the first injection, not after. The rebound after stopping is biology snapping back, not weakness. If FTO, the leptin receptor, or HTR2C are working against you, the medication compensates for those variants, it doesn't correct them. The people carrying the heaviest satiety burden are the ones most dependent on the drug to feel full at all, and therefore the ones facing the steepest rebound risk. Which is exactly why the real protocol gets built during the medication window, not after it closes.
Exosomes and Autism: What I Saw in 20 Patients
Autism has a strong inflammatory and immune component. Dr. Nikogosian describes severe autism as genetic susceptibility combined with environmental triggers. Together these drive chronic neuroinflammation and immune dysfunction that disrupt brain development and destabilize neural networks. Exosomes may work through microRNA “signatures,” not single targets. Exosomes are tiny vesicles secreted by mesenchymal stem cells. Their microRNA cargo fine-tunes gene expression across entire pathways, which may suit a complex, polygenic condition like autism. Early observations are encouraging, but the questions are still open. All 20 patients in his case series reported some improvement, most consistently in motor planning and autonomic regulation. He has seen no serious adverse events across 88 treatments. But this is an uncontrolled case series, there are no human trials of exosomes in autism, and the ideal treatment interval is still unknown.
The Midlife Reset: Hormones, Health & Feeling Like Yourself Again
Understand why feeling different in midlife deserves closer attention. Sleep disturbances, brain fog, mood changes, and declining energy can accompany hormonal fluctuations during perimenopause. Recognizing these changes can help women better understand their symptoms and seek appropriate care. Discover how individualized hormone care may help women feel more like themselves again. Learn why evaluating symptoms, medical history, and relevant laboratory findings matters when considering estrogen, progesterone, testosterone, or other treatments, and why no single approach works for everyone. Recognize why menopause can be a new chapter rather than simply a period of decline. Explore how addressing troublesome symptoms, prioritizing sleep, and making informed treatment decisions can support quality of life during midlife and the years that follow.
Mold, Chronic Illness, and the Future of AI in Medicine
Understand why mold-related illness requires looking beyond a single symptom or diagnosis. Discover how gut health, hormonal changes, environmental exposure, and emotional stress may overlap, complicating decisions about where to begin treatment. Learn why identifying and addressing environmental exposure is central to mold-related care. Understand how water damage, indoor humidity, and HVAC contamination can contribute to hidden moisture problems, and why testing and professional environmental assessment can help guide decisions. Discover how personalized assessment and AI-assisted tools may improve complex patient care. Learn how practitioners can use clinical histories, laboratory information, and AI-generated summaries to organize treatment decisions while maintaining professional oversight and direct patient communication.
Who Decides What You’re Allowed to Know About Your Health? How to Take Back Control
PFAS in the water. Pesticides on the plate. Plastic in nearly everything. Rules about what you're allowed to buy — and even what you're allowed to read — that seem to change every year. The more you learn, the easier it is to feel like nothing you do could possibly matter. Dr. Robert Verkerk has spent roughly 40 years working where health, ecology, and policy collide. His answer isn't to fix everything. It's to start with the one thing you can reach: yourself.On this episode of The Deeper Healing™ Podcast, host Danielle Howley sits down with Dr. Robert Verkerk, founder and Executive and Scientific Director of the Alliance for Natural Health International (ANH), for a conversation that moves from the halls of regulators to your kitchen table. Robert pulls back the curtain on what he describes as regulatory overreach — the restrictions he sees affecting natural health products, practitioners, and even access to health information — and explains why he believes informed choice is worth fighting for. Then he brings it home. Using the familiar oxygen-mask analogy, Robert makes the case that caring for yourself isn't selfish; it's where every bigger change starts. "You can't help someone else in that condition." He walks through the basics he considers foundational — sleep, nutrition, movement, stress, food and water quality, and everyday environmental choices — and explains why trying to change everything at once tends to backfire, and why finding your biggest "levers" and building tiny, sustainable habits may get you further. Robert also shares his framework of four foundations of health — energy, structure, environmental information, and gene expression — and how he connects them to resilience, adaptability, and our relationship with the natural world.The takeaway is a hopeful one: you don't need a perfect environment to begin. You need a first step. This episode shares professional perspectives, commentary on health policy and regulation, and general information about environmental health. It is for informational purposes only and is not medical advice. Individual experiences and outcomes vary. The discussion does not establish any environmental exposure, supplement, natural health product, dietary practice, or other approach discussed as a cause, prevention, or treatment of any disease or medical condition. No statement in this episode should be interpreted as a recommendation to start, stop, or change medical treatment.
Proactive Bone Health and Osteoporosis Prevention
Discover why bone health deserves attention long before an osteoporosis diagnosis. Bone development begins early, while hormonal changes around perimenopause and menopause can contribute to bone loss. Knowing your individual risk factors can help you have earlier conversations about screening and prevention. Learn how resistance, impact, and balance training can support stronger bones and help reduce fall risk. The right exercise depends on your current bone health and abilities, and professional guidance can be especially valuable when osteoporosis or osteopenia is already present. Understand why a DEXA score may be only one part of evaluating bone health. Additional measures of bone quality and bone turnover, along with nutrition, absorption, underlying health issues, and fracture risk, may help clinicians develop a more individualized approach to treatment.
What Eating Only Safe Foods Can Do to Your Nutrition
Real physical or emotional distress when food looks or smells different than expected. Missing entire nutrient categories. Avoiding restaurants, parties, and travel because of what the food situation might be. An adult quietly building a life that works around it without naming it. It’s not about vanity. It’s a nervous system managing and surviving. #Neurodivergent #Neurodiversity
How to Fast Without Sacrificing Muscle
Discover why more fasting is not always better. Jim LaValle explains why extreme daily fasting patterns may increase metabolic stress for some people, while a more natural 12- to 14-hour overnight fast may better align with circadian biology and long-term health. Understand why protein and growth signaling require balance. Muscle is critical for healthy aging, but constantly stimulating pathways such as IGF-1 and mTOR through excessive intake may work against longevity goals. Uncover how fasting can function as a metabolic reset. Periodic fasting may support autophagy, improve metabolic signaling, reduce what Jim calls “metaflammation,” and help people rebuild a healthier relationship with food without sacrificing lean muscle.
Helping Families Reduce Childhood Eczema Triggers
Discover why pediatric eczema care may need to consider the skin microbiome, gut health, nutrition, stress, and environmental exposures—not only lotions and topical treatments. Understand how skin pH and Staphylococcus aureus colonization may influence eczema, and why Dr. Temple discusses microbiome balance and hypochlorous acid in skin care. Learn how reducing added sugar and processed foods while introducing simple “plant points” may help families build dietary diversity without overwhelming picky eaters.
The Better Question: What’s the Secret Saboteur to Longevity and Wellness?
Encapsulated Toxins May Be Hidden From Standard Testing. Dr. Erika Schultz explains her framework for how repeated exposure to toxic metals may lead the body to surround deposits with fibrous or fatty tissue. Once encapsulated, these metals may no longer appear in standard blood testing while potentially continuing to affect surrounding tissue. The Vagus Nerve May Be a Critical Link Between Toxic Burden and Chronic Symptoms. The episode explores the vagus nerve's role in communication between the brain and organs, as well as its connection to the body's inflammatory response. Dr. Schultz discusses how potential damage to the nervous system may contribute to symptoms involving energy, cognition, digestion, hormones, immune function, sleep, and more. Deep Detoxification Requires Sequence, Not Speed. Dr. Schultz explains The Resiliency Method® as a three-phase approach: first supporting drainage and elimination, then creating the biological conditions for cellular detoxification, and finally addressing deeper encapsulated toxins. She emphasizes that the process is individualized and designed to allow the body to lead rather than aggressively forcing toxin release.
Welcome to the Women’s Health Show with your host Dr. LaKeischa
I'm Dr. LaKeischa, integrative GYN, speaker and best selling author. I help ambitious women who are struggling with depleting hormones, get their hormones balanced, regain mental sharpness and have energy to last the entire day.