#24 – Microdosing Psychedelics: Evidence Updates, the Placebo Response, and the Neuroscience Behi…

Microdosing has gone mainstream and is often described as a tool for creativity, mood, productivity, and emotional healing. But what does the science actually say?

In this episode of The Trip Lab, I take an evidence-based look at microdosing psychedelics. We explore what microdosing is, how it differs from full-dose psychedelic therapy, and the proposed neurobiological mechanisms that have been suggested in the literature. I review what current clinical trials and placebo-controlled studies are showing so far, and where the data remains limited or inconclusive.

A central focus of this episode is the placebo response. Rather than treating placebo as “fake” or irrelevant, I explain how expectancy, meaning, belief, and context produce real, measurable changes in the brain and body. We discuss why placebo responses are especially strong in interventions involving consciousness, perception, and mental health, and how this helps explain why many people genuinely feel better with microdosing even when objective outcomes are mixed.

This episode separates enthusiasm from evidence, explores where microdosing may be helpful, where claims get overstretched, and what questions researchers are actively trying to answer next.

If you’re curious about microdosing and want a grounded, medically informed perspective that respects both science and lived experience, this conversation is for you.

For more from me beyond the podcast, come hang out on Between Mind & Body on Substack, where I share full podcast transcripts and deeper companion content, essays, physician-created guides, emerging research, and the questions medicine has not quite answered yet.

Substack: Between Mind & Body (https://drmaryella.substack.com)
Instagram: @drmaryella (https://www.instagram.com/drmaryella/)
LinkedIn: Mary Ella Wood, DO, ABOIM (https://www.linkedin.com/in/mary-ella-wood-do-aboim-060459287)

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