Biological Age Vs. Chronological Age: Epigenetic Strategies To Stay Younger, Longer

Introduction to epigenetic age reversal 0:00

We showed in our treatment group a epigenetic age reversal of over three years as compared to the control group. So it was the first study of its kind. That was the third looking at these epigenetic clocks in humans. But it was the first with a control group. So we could see that we did something differently than the control group did. It was also the first diet and lifestyle intervention. So it was it was a cool first and a lot of things. This is doctor talks. All right. Welcome everyone. This is Doctor Rudy Mueller.

And today we are joined by Doctor Kara Fitzgerald who is a leader in epigenetics and longevity research. Her groundbreaking clinical studies have shown that a targeted diet and lifestyle intervention in reversing biological age is possible, and we can get that reversal anywhere from 3 to 4 years, men and women, within just eight weeks of intervention. So Doctor Fitzgerald is the author of The Younger You and the companion cookbook Better Broths and Healing Tonics sharing the science behind her approach, really, to Aging and Reversing aging.

She's a natural path physician with extensive training in nutritional biochemistry, has contributed to key functional medicine texts, and was honored with the Rosalind Franklin Society Special Award in Science for her research. I have had the privilege of listening to Doctor Fitzgerald speak at numerous conferences, whether it be a forum or the Institute for Functional Medicine. So it's a pleasure to have you on today and to hear your expertise.

What biological age means 1:32

Doctor Fitzgerald. Yeah, it's great to be with you today. Thanks for inviting me on. Yeah, absolutely. So I think just to kind of start what when people hear biological age, you know, what should they be thinking? Biological age is. And then let's dive into a little bit more detail around epigenetics and longevity. Yeah for sure. So chronological age is the number of birthdays we've celebrated. You know we can't change that. It is what it is. Biological age is the rate that we're physically aging.

And that's where science is really putting a serious stake in the ground or many stakes in the ground, because it turns out that we have, say, in our rate of biological aging. I mean, we all know people who look older than their chronological age, and we know people who look younger than their chronological age. And there's actually a really interesting study suggesting that that's accurate, that if we look old, in fact, if you measure the rate of aging, that individual is probably aging at an accelerated rate.

So there's just an epic amount of science happening right now in investigating biological age and how we can, you know, slow it down. Yeah. And I think I mean, obviously you're leading that movement in your research. So when we're talking about your work, it really emphasizes the importance of epigenetics in aging. So could you explain to us a little bit about epigenetic modifications that really influence this aging process. And then what are some practical steps we can take that will positively affect our epigenetic expression.

Yeah. So I want to just I want to give a little bit of background. There's a little bit of a tussle happening in the scientific space right now as to, you know, there's a variety of tools around measuring biological age. The aging phenomena is incredibly complex. And so one of the things that we're doing is we're tightening up our terms. And what I would say that we showed in our research is that we slowed biological aging as measured by the epigenetic clock. So we changed specifically the epigenetic fingerprint of individuals stored something more useful.

How epigenetics shapes aging 3:40

It's it's incredibly important. But there's this there's this background tussle in the scientific community that makes me want to get my terms, you know, buttoned up. So epigenetics is above the genes. Epigenetics is the study of the scientists, the of all of the biochemical variables that are influencing gene expression. So we've got the same DNA really in every DNA carrying cell with the same thing. But an eye cell is very different than, you know, a skin or a muscle cell or a heart cell. I mean, it's very, very different.

And this is epigenetics. So we've got these biochemical marks allowing different gene patterns to be expressed in different cell types. It's extraordinary. And there is a continuum of epigenetic expression. So when an eye cell is not going to become a liver cell. So those epigenetic imprints are lasting, they're not changeable. And ISIL will always be in cell or retina cell or whatever, you know, whatever cell type you're you're thinking of. But then there's this area that's rich with change where how we eat, how we live, how we feel, what we're breathing.

You know, just if we're moving our bodies, the stress load that we're under, these variables can very profoundly influence epigenetics, i.e. influence gene expression. And it turns out that we just have an incredible amount of say in whether we're optimizing gene expression by our choices, our daily choices, our habits or not. And it turns out B's choices really make a difference in epigenetic clocks in the rate of biological aging. So this is you know, this science is new. It's exciting. Just as I preface, there's a lot of change and growth happening.

But the bottom line is that, you know, we're being validated over and over again. You know, things that our moms and our grandparents told us, you know, eat your vegetables, you know, exercise, just all of these, these this tried and true lifetime of wisdom. I mean, there's really some truth in this when we look at gene expression. So let me just put a pin in it there. And yeah you can ask me something some clarifying questions. Well I think you know, the importance of lifestyle and the impact on epigenetic age is I mean, it's the foundation, right?

We learn it through the Institute for Functional Medicine. We have that corps base that we need, the foundation that we need to be focused on, whether it be diet, lifestyle or exercise, sleep, stress, relationships, connection to religion, connection to purpose. So outside, I mean of those things, what are you really seeing that are making a big epigenetic shift when it's concerning biological age within your research? Just I want to say again, yeah, you know, putting it, looking at it through a functional medicine lens is is just so exciting.

You know, just to have the science, you know, validating what we've been teaching in the functional medicine model forever is ridiculously cool. So it turns out our dietary pattern, you know, what we think is healthy for the most part probably is the dietary pattern that we use in the younger you program is very dense in veggies, colorful green veg, lots and lots of them, fruits, berries, things like that. It's dense and high quality protein, mushrooms, a whole array of spices, things like rose, rosemary or turmeric.

You know, green tea, varieties of peppers. I mean, actually the list sort of goes on and on. Seeds, nuts, you know, fatty fish, etc.. So a dietary pattern. Eggs, let me say eggs, liver. If people are are willing to eat liver the dietary pattern there's a lot of options. So there's a lot of these nutrients that we've identified to be epi nutrients. That is they favorably influence epigenetics. They favorably influence gene expression. Probably the dietary pattern is doing the heavy lifting in our intervention.

So we've we have a paper in peer review right now looking at all of the elements of what we did to see which had the strongest influence on the epigenetic clock measuring bio age. And it was nutrients. In fact, it's a particular collection of epi nutrients that we call methylation adaptogens. These are phytochemicals. So, you know, compounds coming from plants. Polyphenols are one of the groups of these compounds. And so these these veggies really seem to do the heavy lift. I mean, we would argue that the whole dietary pattern together and not just isolating these nutrients is, you know, is where we see the benefit.

But when we look at the data, it suggests, you know, definitely your veggies, eat your colorful veggies, get your turmeric, drink some green tea, etc. that those seem to be particularly important players. I love it and you know, I remember, you know, Deanna minnick and her research around eating the rainbow. And so in integrating this with people in the research or people

Dietary patterns and epi-nutrients 9:00

that are going through the younger you program, their particular tips around how many blues or purples or greens or reds they should be trying to get in. So we want people. This is an eight week intensive program, and we'll just I'll underscore that one needn't live this diet all the time. You know, you're in and year out unless, you know, unless it really works for you. It may be something that you choose to do a couple times a year. We have people do that and repeat with us. But you're going to, you know, just hunker down and know you're going to be eating a good chunk of edges.

You're going to be doing like anywhere from 7 to 9 cups. You're going to be doing quite a bit of greens. Again, the colorful cruciferous, you know, sulforaphane is beautiful compound. That's an EP nutrient extraordinaire. So it's a matter of just kind of being with the idea that it's going to be a vegetable intensive moment, plus others. We're not leaving out protein, we're not leaving out good fats. And then just, you know, hunkering down and being willing to get those in. One of the cool, cool things about the book.

One of my favorite parts about the book, Younger You, is that we've got a 30 page epi nutrient appendix. So if you're wondering what to eat, what you can eat, we actually have a down and dirty diet that we're going to give your listeners the full program in a, you know, PDF reference. They can download it and they can see all of the target nutrients to go for. But if you want sort of the breadth of the nutrients in our in our book publication, that appendix is fabulous. So what kinds of greens do we know are epi nutrient extraordinaire, what kinds of colorful and cruciferous, etc.?

It's just it's just this massive 30 page nutrient appendix that only nutrient epi nutrient appendix that I'm aware of. But you can go in there and just make sure you're eating what you like. You can see what you're already doing. But yeah that's a it's it's it's a veggie intensive program. There's there's no no ifs ands or buts around that. Yeah. Nice. Nice. And I think one of the things that you emphasized earlier that I think is often overlooked is really the herbs and the spices and how much they can benefit.

So you mentioned rosemary and turmeric. There are any ones that any other ones that you're noticing are making and helping shift that or contributing to that shift in biological age. And if so, how are the mechanisms that they're that it's, you know, that you think it's performing to be able to do so? Yeah. I mean, name spice, you know, time, sage, Pepper, you know, a variety of peppers. I've lived here. I live in Mexico now. You know, arguably the pepper country in the world. There's hundreds of different pepper types.

And I have no doubt that they how's important, important, important epi nutrients. So our spice rack in general is just incredibly bioactive. It's just an EP nutrient, you know, wonder resource for us. So there's many, many, many they influence the enzymes involved in, you know, methylation involved in methylation, one of the fundamental biochemical processes that influenced gene expression, which genes are on and which genes are off. And so we want the best genes on the ones that are associated with health and longevity.

And we want the ones that promote disease to be really turned off. I mean, it's that simple. And so these nutrients seem to influence how that is happening. So there's two components. There's two nutrient classes in the diet we want to support. Again DNA methylation. More broadly we want to support this biochemical process called methylation. Foods like eggs, liver, leafy greens, mushrooms. Fatty fish can support methylation foundationally. And then you need to direct sort of how and where methylation is happening.

And that's this layer of nutrients. And to your point, spices are a rich, rich, rich, rich resource of these sort of traffic directors. So methylation we want methylation to be happening with the foods in our diet. We want to support methylation with the foods and then direct how and where methylation is happening specifically. So good genes are on. And then, you know, bad genes are off. And so we can do that through all of this information that we're getting from our food. But then circling back to a study that we've got in the works right now, those the class of epi nutrients called methylation adaptogens, the spices, the polyphenols, the colorful fruits and beds really seem to be, you know, extra important, beautiful.

And so one one tool that I've really utilized from I think your teachings and Diana teachings is providing our patients with food diary. Right. Might be mindful of what you're eating, but then also to be able to like grab a box of crayons or markers and then be able to label out, you know, I ate four greens today and two blues, purples, reds, oranges and then really track that over the week of that food diary to be able to see what kind of nutrients they're getting in, just as a way to take inventory of what you're doing before implementing a program like the younger you program, and then while you're implementing the Younger you program.

So I can appreciate so much how those polyphenols, those nutrients that were getting from those wide variety of vegetables and fruits and spices really can impact our, our epigenetics. And, you know, even the methylation, I like that. I mean, that's that's fabulous. That's a really, really nice tool that will, you know, will resonate with some people. And in doing this, I mean, that's one of the things that there's in the group we spend a good deal of time on. How do you get these in, you know, and what are the creative preparation methods, doing smoothies, etc., to make sure you hit the targets of the younger you program.

There's somebody there's a woman who reached out to us recently who has done an extraordinary job above and beyond, kind of reversing her biological age as measured by methylation, who just thinks about it in quantity. She's like, you know, I basically eat it pound of veggies a day. So you could do that. You could just pop them on the scale, measure out your veggies, and then just get that in over the course of doing the intensive program. Sure, sure. So when we're talking about nutrition, I kind of want to stay in this in this lane for a little bit.

Talked about 7 to 9 servings of vegetables, maybe a couple of fruits in there as well. Herbs and the diet being heavy in there. We talked you mentioned liver, which I definitely want to hit on liver because some people can't handle that. We talked about fatty fish or, you know, maybe potentially good, good lean protein sources, eggs being another one with the choline benefit, I would assume, for the methylation when we're talking about. So that's like what to eat. How about when to eat. Is there is there a fasting recommended with inside of this program.

And that within that eight weeks or or where do you see fasting fitting into something like this? Yeah. So in our research we've only it's a very gentle structure, intermittent fasting structure. So 12 hours on 12 hours off which, which some people would just call normal eating right stop after dinner basically. I mean I know today in this, you know, in that world we live in now, people are sort of north, you know, all day and all night. But we want people to have a hard stop, really, after dinner or maybe, you know, three hours before bedtime.

So just 12 hours on, 12 hours off. We wanted it to be just broadly adaptable. We really wanted this program to be doable, really by by virtually anyone. So we and the other pieces is that we didn't want to research. We didn't want to turn it into a fasting research study. So we just we just looked looked at this in it, you know, in what we know we can do. So we we actually worked on this program in our clinical practice for years before we got to research. And the design, as it is, was what was most broadly adoptable by our patient population.

Yeah, it makes a lot of sense. So I want to touch on before getting into the research itself and hearing about what kind of exciting things you were seeing there and then I'd love to hear a little bit more about the one that's in peer review currently. What about liver? So yeah it's funny. Yeah.

Vegetable targets, spices, and fasting 17:20

So it's funny. You know, I'm thinking when we originally submitted our paper that, you know, kind of put us on the map was I think it was the third paper ever really in the world to show this biological age reversal phenomenon measured by epigenetics. So, yeah, we got a lot of attention. But one of the peer reviewers said, you know, what's up with liver? You got some pushback from a peer review. It's really funny. But, you know, if you have a nutrition background, if you have a background with, you know, thinking about nutrition, biochemistry, thinking about nutrient density, you know, that liver is, I think, without exception, the most nutrient dense food on the planet.

I mean, it's a multivitamin in a food matrix. It's a multivitamin mineral, actually, there's there's plenty of minerals in it. So it's just this incredibly nutrient dense food, and it's delivered in a food matrix. So it's delivered with and, you know, all of these accessory compounds that help with bioavailability, that help you know, that deliver the appropriate nutrients and the appropriate structure for our body to use. I mean, we can't create that, you know, in a synthetic hell. I mean, we just can't do that.

I'm a fan of vitamins, you know, I take them myself. I prescribe them all of the time. But I definitely have a food first approach. And, you know, you can't beat liver. But how do you do it? You know, how do you actually take it? Our when we looked at adherence data in our, you know, two publications out now, one looking at men, one looking at women liver especially in the first study was pretty poorly adhered to. People don't like to eat it. Nobody knows how to cook it. It doesn't taste great. You know, for me, the only liver I like really is like liverwurst or Patty or something like that.

And it's. And it's hard to find, you know, really good, clean source paté sometimes. By the time we did the women's, we were recommending liver caps. So you can buy super clean sourced mostly from New Zealand liver capsules. And if you take, you know, you don't even have to take six. A serving size is six. You can take a little bit less than that to adhere to the our recommendations and hit your liver targets. And and that's what I do now like I'm not cooking liver you know and there's not a heck of a lot of pity that I found down here in Mexico.

So I do liver caps. Okay. Cool. All right. Yeah. So I'm German, and my dad was the first one born here from Germany and my family. So liver was something that he really enjoyed. So liverwurst. It sounds amazing to me, but I know what they do to those animals prior to getting the liver. I mean, they, they feed them all of this crap to be able to fatten the liver up anyway. So if you can, I mean, if you can find an organic source of liver, obviously that's what we're we're looking to target. But I love that we can do liver caps as well.

I know it's easy. You just have to make sure. And I talk about sources in the book a lot. It and you can get the book these days books for pretty cheap on Amazon. There's used available and there's the paperback is out now. But you need to make sure that that it's not defeated. So you can get this freeze dried non fatted liver. And you're good. You know it's it's liver in a capsule. It's it's you know it's freeze ride liver and a cap. You're basically getting you know exactly what we're recommending.

Yeah. Perfect. Yeah that's that's great because I can only just imagine my wife in the kit coming into the kitchen is me. I'm cooking up liver and her reaction to the smell of it. And if you can handle it, liver is a great source for for many vitamins and minerals. And if you can't, liver caps may be the way to go. Yeah. So with, you know, with your research on the methyl aging and aging reversal, can you talk to me a little bit about your study on that process and kind of maybe some of your trials and tribulations and the implementation?

I know the first studies with men. The second study was women with with women. And then what were the findings that really got you excited about, you know, where this was headed? So this was a program that I started thinking about. So I started to really keenly think about epigenetics, you know, gene expression through a functional medicine lens in, you know, maybe 2013, 2014. That's when the research was really sort of coming across my desk in a manner that really prompted me to stop and read it.

Most of the epigenetic science coming out at that time was looking at cancer, because cancer very potently hijacks epigenetics, hijacks gene expression from us, changes gene expression in the tumor microenvironment to push the cancer growth forward. So it really takes it over from us. And my biggest question was are we influencing this favorably or not in functional medicine? And my sense was that we, you know, that we were that was my hypothesis. And are we doing it favorably? As I teased that out, it prompted me to, with Romilly Hodges, the director of our nutrition programs, to create this diet and lifestyle pattern, I could see that we needed.

So methylation always needs to be supported as we age. We're not doing it as efficiently. DNA methylation is just one type of methylation process happening in the body. There's hundreds of enzymes doing all sorts of things, from metabolizing estrogen to making adrenaline and dopamine, etc., etc. that require methylation. And it's just a carbon with three hydrogens. Going back to really basic biochemistry from high school. But we're doing this process. We're either taking this carbon in three hydrogens and putting it on to change compound activity or taking it off, or we're making them in something called the methylation cycle.

As we age, we do this less efficiently. And this is this definitely shows up in DNA methylation. We do it less efficiently. So we knew foundationally we needed to support methylation. And so we include tons of methylation foods. And that includes livers. We talked about to your point eggs you know decent protein mushrooms greens etc. etc.. So there's tons of foundational support for methylation. And then we layered in optimizing methylation. And it's these cool polyphenol compounds that seem to direct traffic.

So that methylation is happening on the genome like where we want it to. And going back to cancer, which was our original question. There's also there was this a lot of in vitro. So cell studies or animal studies. So preclinical not looking in humans but showing that these polyphenols are really incredibly important players in allowing like those genes that the tumor microenvironment can turn off. I mean it's amazing. So we look at these beautiful polyphenol compounds and see that they've got this monumental epigenetic role in protecting us from cancer.

And we can actually see this in like the chronic diseases of aging more broadly. But the most of the science is looking at cancer. And so we built this program out sort of looking at the lens of cancer. Aging came in so biological age as something that could be reversed was a pipe dream. When we first started this investigation. I mean, we weren't we weren't even thinking about it when we midway, I mean, we so we knew that we would be able to measure that a clock was available and that we would be able to look at it.

Liver, methylation, and food sources 24:50

But I wasn't holding my breath around changing it. I did have I did expect or hope that we would be changing gene expression, changing epigenetics favorably. But in terms of changing the epigenetic clock, you know, we just hadn't seen that in humans. And Steve Horvath, really the father of this field, didn't think that it was possible in humans. So it was mid-way in our study that the first paper was released showing that these epigenetic clocks could be reversed in humans. And that was the Trim study led by Greg Fay.

And it was extraordinary. I mean, it was extraordinary. And we were underway already, but it made us, you know, it just was an exciting thing. And we were excited to look and see if we may have, you know, if we influenced the the first clock at all. So when we did, you know, when we finished our study and we started to do our analysis and saw that we in fact had a favorable influence on Steve Horvath clock on the it's called the multi, the pan tissue clock, the 2013 pan tissue clock. It was a big deal like it was.

It was really really exciting for us to to see that we had done that. And you know, you know commensurate to that finding the paper got a lot of just a lot of attention. It was very, very exciting. So we showed in our treatment group a epigenetic age reversal of over three years as compared to the control group. So it was the first study of its kind. So it was the first in a lot of ways it was the third looking at these epigenetic clocks in humans. But it was the first with a control group. So we could see that we did something differently than the control group did.

They didn't have that same change. And it was also the first eight diet and lifestyle intervention. So, you know, just it was a cool first in a lot of things and offer forever be grateful to, you know, Brant Ek at Meta who he was their CEO at the time who green greenlighted this. He gave us they gave us an unrestricted grant to study it. I mean, just I feel just enormously grateful for that and for their support in doing it. Super, super exciting. So yeah, it was it was a first for a lot. We've since gone on to not only tease out the heavy lifting nutrients, but we're also looking at.

So we started by looking at the clocks and now we're looking more broadly and we're writing up an iOS investigation. So this is called this is an EP genome wide association study. So beyond just those methylation marks associated with the epigenetic clocks, the next question is how are we influencing methylation more broadly or gene expression more broadly. And it turns out, you know, that original question looking at cancer and looking at some of the gene changes, we can see that our study, in fact, favorably influenced some of those genes that the tumor microenvironment takes over. So we're pretty excited about that.

And that's a fourth publication that will come out or that will we're writing right now, but we'll submit it in the not so distant future. So just all sorts of exciting things to investigate and unfold with, you know, with what we've created and what I like about the younger you program and the content of the book, and then the research that you've done in reading those reading the two that were published from the male study and the female study, was that it really is geared towards the things that are modifiable, that people can change rather easily.

It's not some expensive, you know, gray area intervention that we're that you're implementing to try to reverse biological ages, things that people can do today. Yeah, yeah, yeah. Well, and it's a healthy dietary pattern by any measure. And then of course we have. Yeah. It's just like it's like a one on one really healthy dietary pattern. You know it's good. It's good fats. It's rich in it's a little bit keto leaning. And we do have you know the triglycerides in our participants dropped significantly.

So we likely put them into some background ketosis. There's a gentle intermittent fasting structure. It's anti-inflammatory. It's hypoallergenic. So all of those really foundational and important things that, you know, as a functional medicine physician, are baked in to this dietary pattern and then layered in our, you know, basically every single bite, every morsel of food is is an EP nutrient is packed with a complex interplay of epi nutrients. That's the perhaps the unique angle that this dietary pattern has from, you know, other dietary patterns that we really built that with it, you know, with the epi nutrient influence in mind.

But it's also, you know, brick by brick layered into a just a smart dietary pattern that I think anybody trained in functional medicine would, you know, agree with. There's no alcohol for the eight weeks. I'm sorry, folks, after the eight weeks, yes, you can you can go back to drinking. But there's you know, it's anti-inflammatory. So we pull some foods out that you may love, but it's just again for the state week window. And then once you get to the other side of that, you know, you can bring them in depending on how your body responds to that.

And then just to your earlier point, we bring in lifestyle pieces as well. Do you want me to talk about those? Yeah. Are we are you ready to talk about this? So they're they're important. We've been giving the diet. We've been talking about the diet a lot here. So it turns out sleep is an epic nutrient. Exercises in epi, nutrient stress reduction, some kind of an intentional stress reduction practice or epi nutrients. That is, they move favorably DNA methylation and epigenetics more broadly. So all of the lifestyle components that we added to this intervention have research on them showing favorable changes with good habits and really conversely, negative changes with bad habits.

So if you're not sleeping well, you're you're aging.

Study design and age reversal results 30:40

You know, we know that this is true by many different measures, not just by epigenetics. But if you're not sleeping well, if you're not, you know, if you're not hitting your targets there, it's pro aging. Unfortunately, stress is potently pro aging again by many different measures, including the epigenetic clocks. High chronic stress. I'm not talking about short term sort of healthy stress of exercise or, you know, something exciting happening, but just that long term grind that so many of us in the US are exposed to that is incredibly pro aging.

Meditation, it turns out, is anti-aging. No great surprise there, you know, whatever that looks like. So we used a simple meditation exercise called the Relaxation Response, created out of Harvard many years ago by somebody named Herbert Scientist. Their name, Herbert Benson, the Relaxation Response. It's a simple breathing exercise, and we wanted people to do that a couple times a day. I think, you know, likely, I mean, and the research suggests that a good prayer practice, a yoga practice, a Thai chi park, like there's many ways we can we can do that.

But in our research today, we've used the Herbert Benson Protocol exercises and epi nutrient extraordinaire, I mean exercise, if you're looking at the epigenome, you know, looks like kale, I swear. Like it moves some of the same genes as, you know, a really good, you know, veggie choice does. It's amazing. It will help those negative cancer patterns that I talked about very potently. And one of the cool studies that I love so much is that it's most effective in older adults. So the epigenetic benefit of exercise is actually true the older you are.

How cool is that? So every element of the program is designed to optimize epigenetics and specifically DNA methylation. I like the reclassification of these lifestyle factors as epi nutrients. Right. Because all of them are are impacting that epigenetic or the epigenome. And also, you know, can be considered or thought of as a nutrient because of how it's impacting the epigenetics. So it's similar. I know, like if you could do a blind study and say, what's this budget? Or was this exercise, I mean, I don't know that you would always be able to tell the difference.

It's pretty cool. Yeah, that's really neat. You know, something that you mentioned earlier was community and connection and prayer practice. You know, like a connected. We obviously couldn't study that in a, you know, in a randomized control study like have, you know, the control group, no community, no contact. And then, you know, our group, lots of community, lots of hugs, etc.. But of course, those are important players as well, you know. And science bears that out. Yeah, I think, you know, a lot of the research that that the retrospective research looking at the blue zones and seeing all of the commonalities between these different areas, whether it's Okinawa or Seventh, the advantage of the Adventists.

Yeah. You know, they have that. They have the community. They have, you know, a higher power. They have prayer, they have movement involved. And it's not go out and let's jack up your VO2 max and see how great we can get that. Although I think that can be beneficial, not trying to take it away from it, but it's just movement, regular movement that we were designed functionally to do. So yes, that's right. I couldn't agree with you more. You know, on both ends, you know, if you're if you're up for some high intensity interval training yet smart.

We didn't we didn't put that into our program again because we wanted it to be broadly doable. So our exercise recommendation, it was simply, you know, a minimum of 30 minutes, five days a week with a perceived maximum exertion between 60 and 80, a perceived exertion between 60 and 80 of your max. So what you think is 60% to 80% of your max, and you choose what it is you want to do. So yeah, I'm an exercise. You know, I'm a committed, fairly intense exerciser. But, you know, for this program, we we're meeting people where they're at.

Yeah. And that's that's what's really nice about the program too. So to shift kind of gears from being, you know, more group oriented to maybe more personalized medicine, you know, obviously with the background and functional medicine. And we are implementing personalized interventions that are specific to an individual. I mean, are there are key markers that people should be monitoring to optimize their specific health or slow aging or reverse biological age? Such a good question. So I would say, yeah, I have a couple of thoughts there.

If you have the book or if you go to the website and on your summit page, there's a downloadable and you'll get all of the details to get over to my website and find these things. We have a biological age quiz. I mean, that could be the first entry point into this conversation. If you're completely new to thinking about biology, you could take this quiz and this would give you an idea of what your habits are looking like. You know? So it's I think it's very useful. And we've recently looked at it in relation to the one of the key epigenetic clock.

We're using this these days to see if there's any correlation. So we looked at 70 individuals who took our quiz and did this clock. And we saw that it's actually tightly correlated. It's that's great. I know we designed it you know with the best science. And we used a group of people to figure it out. It wasn't validated. But now we're actually validating it and seeing it tracked. So as far as a budget biomarker because it's 100% free, you could start with our quiz. But to that to you know, to your point, beyond that there are the clock that we use currently is something called the pace of aging, the pace of aging.

There's just great, great data on it. And I think it's a fun tool. I think it's an important tool that we can incorporate it into an overall wellness plan. People like, you know, to that end, people are welcome to work with, nutrition team in this space. But in terms of personal and, and I should say have a personalized bend towards, you know, the younger you dietary pattern based on what your that individuals findings are. But I would argue that, you know, all of us hopefully annually work with a functional medicine provider who can really kind of look under the metabolic hood, look at our essential and our conditionally essential nutrients, look at our oxidative stress markers, look at our inflammatory markers, etc..

You know, do a stool test, do an oral microbiome, you know, just kind of do a cast a net as appropriate and identify what's going on with that individual and correct those things. And then, you know, layer in specific, you know, biological age pieces or concurrently layer them in. But it's to your point that we the personalized approach is so, so, so, so important. Having somebody work with you as you and not just jumping towards the endless bio hacks that were being inundated with these days, you know, just who are you?

I, you know, just a quick a quick case from my practice because I have a lot of these bio hackers coming to see me now, which is fabulous. It's fun. I love working with them, but I look at each individual through a functional lens. And so this was somebody who came to me taking all of the sexy new biohacking supplements out there, and there's many of them not paying attention to the inflammation of allergies, you know, and we know that inflammation really of any form will drive aging forward. So she was defeating herself with these these sexy supplements.

But you know, it's fabulous. We identified it. We saw her individual needs corrected her her protocol. She can continue to do those those supplements. I actually just want I want a first actually work on our foundational stuff. And then we can bring those supplements back in. I'm not I'm not opposed to them, but it's, you know, it's that person. It's that it's that individualized component that we're so good at in functional medicine is that that I just think is essential. Absolutely. And it is so funny because you see the same thing. Right?

But be coming in with blue light, red light necklaces or wristbands or, you know, I mean, I think all of these things have their place methylene blue and taking different sense. And all of these, all these have their place. But really it is beginning at the foundation. And you're really hitting home and echoing what other speakers that we've had on this summit have said. It's the foundation that matters. And and what I really appreciate is how much the research that you've been able to do is backing that.

We I think we all intuitively knew it, but to be able to have it in the research is such a thing. Yeah. Really great. Yeah, yeah. Beside of outside of that foundation, now that we're kind of hitting on some of these, these bio hacks, how are you utilizing technology or AI to help with, you know, whether it's patient protocols or helping with reversing biological agent? Really leave this question very broad so that you can kind of take it where you would like. But I just like to get a little bit more insight from you on how you're utilizing technology.

Is it through biohazard AI? Is it a combination? Well, I don't do a lot of direct charting anymore. Yeah, it's just kind of a which is amazing. It's such a gift for those of us who are kind of lousy charters. So yeah, using AI there I am. We you know, we're using AI in our research for sure. We're using AI in researching patient cases. It's not it's not without pretty intense limitations.

Lifestyle factors, biomarkers, and personalization 40:40

So I would say that anybody who's really in there using it knows that the appropriate questions need to be asked. You always have to, you know, you have to check and recheck everything. So will it expedite the process? Yeah. In this amazingly useful way. In fact, we just looked at all of our genes that we changed in our, you know, initial cohort and compared them to another publication that just came out. I'm going to present this. And we used AI to do that investigation and to help us analyze what genes were doing what.

And, you know, we did it in 30s. Now all of that has to be validated. But, you know, I'll be presenting this. I'm leaving on shortly for a conference and I'll be showing. Wow. Here's all this. There's a lot of overlap. It was a polyphenol. It was an intervention using a polyphenol compound. And then our our protocol. And we can see that there's a bunch of gene overlap. And we did that using AI in about in about 30s. But you know, if we write that up for publication, which we might yeah, we have to do seriously due diligence, drill down and everything.

AI, I am thrilled about some of the technology. So the next generation MRIs with an AI overlay, forget about it for, you know, for brain MRIs, man, it's just game changing. It's game changing. It's game changing. There is using a coronary CT scan with an AI overlay is also game changing. To be able to really discern the type of plaque and the quantity of plaque and the danger associated with it. Game changing and it's only going to continue. So I am very much you know, Peter Diamandis has been talking about it for a while, like the, you know, the AI train is leaving and you really need to be on it.

So I'm very much a believer in that. We need to be kicking the tires of AI for sure, because the possibilities are massive and it's really, really exciting. And you've got to check you absolutely have to follow up with everything like it is. It seems like it's a lazy technology. You know, it's kind of going to give you the lowest common denominator body of information unless you really, you know, make it deliver the quality and caliber of information that you want. At least that's that's been my experience thus far.

But it you know, we use it all the time. We use it in, you know, in content we're developing and editing and just all sorts of stuff. Sure. Yeah. And I think that, you know, I think the most exciting area is going to be in that diagnostic perspective and being able to really quote unquote screen and really understand where we are with, you know, avoiding those big, big diseases that cause, you know, cardiovascular disease, the brain health, cancer. That's really where I think that next phase is going to be the big thing.

And then, yeah, yeah, you know, I think AI we're still really early on if I, you know, give an analogy. And I heard somebody else say this. So I'm not going to claim this is my own quite yet. I'll give it three more times and then I'll claim it as my own. But it's you know, it's like a word word processor or spell check. We're kind of in that area versus being able to, you know, put in a thought and dump out a bunch of a bunch of information when it comes to, in respect to being able to look at a person's labs and genetics and all of that and be able to spit out a protocol that's specific.

So there's a lot of there's a lot of expertise that needs to go into developing that personalized approach. Which individual. Yeah, that's right. We're not and we're we're not there yet. But you know what? I had a so I have a podcast that people can that people can find if they're interested. New fun new frontiers in functional medicine. And I talked to Nathan Price, who is tussling with this. So he was he's at the Institute for Systems Biology, and he's, you know, he's got Thorne as well. And they're working on a, quote, digital twin, which is it's just really cool.

It's really, really interesting. And so to be able to like throw interventions at that digital twin and see it's you. You know. Yeah you get so this digital twin is you and then you can yeah you can go in there and try different cocktails of interventions and see what's going to come, what's going to benefit. Yeah. So this you know hopefully he'll launch it. I had volunteered our clinic to be in the testing. I'll have to circle back and see that with it. But that's just incredibly exciting. You know what he's working on what he and his team are working on.

So if anybody wants to learn about that, that's a they could just go to the website or go to iTunes and just search on unique and Price Kara Fitzgerald and find that conversation. Yeah. And I'll just echo this. You have a great podcast with some really interesting people on there. So definitely if you want to continue to learn more about this, check out her Kara's podcast. Yeah, I think we've covered a lot here today. Is there anything additional that you really want to mention that you're excited about in this space?

And then I'll, you know, then I want you to open it up. And really, if people are interested in learning more about you. We've mentioned the podcast, we've mentioned the book, but where can they get more information? I am ridiculously excited about this space. So I just mentioned the conference that I'm preparing a slide deck for. And, you know, there was a time when I was presenting on the Younger You program, which, you know, we we called it the Methylation Diet and Lifestyle before it was christened the Younger You program.

And there was crickets like there was just nobody doing anything like it. And I think there was some, you know, there was some eyebrows like, what is this? And it was by the grace of, you know, getting this unrestricted grant that we got to really study it and contribute to the first data in humans. So as I was preparing this lecture, I just hopped into look at what's happening using, you know, nutrition and lifestyle interventions, looking at biological age as measured by epigenetics, looking at epigenetics more broadly and the influence of nutrition.

And there are study after study after study after study. So I limited it to 2000, 2000, 2022 to 2024. And there's just a ton. There's an explosion of research in looking at nutrients, looking at polyphenols, looking at lifestyle in humans in this space. And it was just really, really exciting to be able to, you know, report, I will go to this conference and just report on this explosion of science that's happening that we've been thinking about in functional medicine for so long. But the reality is there it is, you know, clinical study after clinical study.

And it's just and, you know, retrospective investigations and all sorts of stuff just, you know, to break neck pace, coming out looking at, you know, nutritional epigenetics. And it's very, very exciting and satisfying. I just, you know, I expect we'll just see this moving forward. And we want to continue to research. We're working on grants through the NIH. We're refining the program. So like the younger you 2.0 in the clinic, you know, thinking about personalized medicine, taking the younger you principles and really interpreting them through the individual.

So just creating a younger program that's individually tailored to that human sitting in front of you and their specific needs, I think I haven't tested it, but I think has the best chance of, you know, the most profound biological age, less epigenetic clock reversal.

AI, future research, and closing remarks 47:40

Certainly. You know, in patient after patient we see really good outcome using the dietary pattern interpreted for the individual. So I just you know, I'm very excited about the field. I'm just really, really excited. I think some of those more sophisticated and sort of out there hacks are probably going to come to pass and become a part of the functional medicine world as well. Those are still, you know, thinking about Yamanaka factors and so forth and so forth. They're not ready for prime time in humans at this point.

But I have my eye open on it, you know, and to your point, bringing AI in and doing the heavy lift for us. Yeah. You know, I've got my eye towards that as well. So it's a very exciting time. And then, you know, coming over to our website. So first of all we're going to gift you with the program. It's an awesome, beautiful PDF of all of the important elements of the program. So your listeners will are the people who are participating in the summit can download that and get it. And then if you want to have that interpreted for you by one of the nutritionists on my team, or one of the physicians who know this inside out and who've participated with me in the research around it, you can work with our clinic.

And then I'm also adding that we have that bio quiz. So get the download, it'll guide you over to the website. You can, you know, figure out what you want. And I think, you know, I think people will enjoy, you know, incorporating some of these younger elements into their lives. Well, certainly it's a very generous gift and greatly appreciate it. Thank you for your time today, Doctor Fitzgerald. Appreciate you. And yeah, I mean, it was a great interview, and I think that we've simplified things and the research that you've been able to provide with reversing anywhere from 3 to 4 years in the biological age is impactful.

And I love the fact that if I go into PubMed and I search epigenetic age or biological age and interventions or polyphenols, I'm probably going to see this hockey stick that really, you know, you were at the beginning of and now we're seeing more and more research. So it's so exciting. Yeah. Yeah really cool. Well thank you again I appreciate your time. Yeah. Thank you. Thank you for tuning in to Doctor Talks. We hope today's episode has enlightened and inspired you on your path to optimal health.

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