Full Transcript Introduction to ProLon and L-Nutra 0:00 Hello everybody. 0:00 Welcome to a very exciting lecture, interview, conversation 0:05 reunion of two friends. 0:07 I get to speak to somebody who's so busy 0:10 and all over the world, doctor Williams Hsu is a medical doctor. 0:14 He's chief medical officer of L Neutra Health. 0:16 Many of you know for sure that I'll neutral. 0:19 There's a parent company for the commercial product that I post 0:23 about talk about podcast about all the time. 0:25 Prolong the five day fasting mimicking diet. 0:28 So, this gentleman that I'm talking to now is in charge of the science behind 0:34 what that product does in the other division. 0:37 The L neutral division. 0:38 We're going to talk about which many of you listening that are aware 0:43 that maybe 80% of Americans have a metabolic health problem. 0:48 There's a new term c am syndrome, cardiovascular, kidney, metabolic health. 0:53 And it's estimated that 80% of Americans fall. 0:57 Unfortunately, 0:58 and it's probably true of most of the Western world, 1:00 if you happen to be beaming in from somewhere 1:02 other than the United States, have a c k am syndrome. 1:06 So I think there are solutions we're going to talk about. 1:09 But let me first formally welcome you, all the way from cold, 1:13 still wintery, unfortunately. Boston. 1:15 Thank you for being here, Doctor Kahn. Thank you. 1:18 And, always such a pleasure to have a conversation with you. 1:22 Yeah. 1:23 And, you know, for people that are listening, 1:25 they may not know the term translational medicine, which is, 1:29 you know, basic science and early animal research if needed. 1:34 But trying to move that when appropriate into the human sphere. 1:38 And few companies have done 1:39 that as well, particularly if we talk about food as medicine. 1:42 This is a reversing heart disease naturally. 1:45 Summit. 1:45 So anything you can do with food 1:47 is undoubtedly going to fall under the natural column. 1:50 So your your whole entity does that so well of course 1:54 led in the scientific team by doctor Walter Longo. 1:57 But I think we see more of you though. Always hear him. 2:00 He's, still with his 2:01 his cells and his, mice and and then translate them into human. 2:05 So maybe if by chance, somebody listening isn't 2:09 familiar, let's just spend a moment on what pro on is. 2:12 I mean, what physically it is. 2:15 Briefly describe it and I'll be quiet. 2:18 Know the the fast moving diet, what we call FMD, it 2:21 really is, is a structural meal plan that essentially gives you 2:27 it really rejuvenates the cells from from that level, that gives you 2:32 the benefits of, of like a five day fast, except that you don't have to fast. 2:36 It's actually nutrition that flies under the radar.
How the fasting mimicking diet works 2:40 So the cells think that you're fasting when in fact you're getting nutrients. 2:44 Now why do we do this is because kind of the 2:46 the age old truth that the cells and the biological life 2:51 forms always have a way to deal with adverse environment. 2:54 And in the old days when food wasn't available, the cells had, you know, 2:58 through, in fact, every cell in the body respond to the stress of no food 3:03 and came up with a way to take that every stimuli 3:06 from the outside in turn into something that makes the cells younger. 3:10 And so this five day test, the mimicking diet would address 3:13 that cellular rejuvenation. 3:15 And and lowers the biological age. 3:17 And it actually has the potential to reverse many age related 3:21 chronic conditions, which we'll talk a little bit more later. 3:24 All right. 3:24 So we're talking about in fact my laptop, which I'm using via 3:30 the internet to speak to you, the miracles that we have nowadays 3:34 is resting on a box that says parole on it's science is not a diet, is it? 3:39 Actually raises my laptop. 3:42 I love 3:42 also, I always keep a full or an empty proline box around. 3:46 It's empty because I've used it. 3:48 The last time I did the five day fasting mimicking diet 3:51 was a group fast that I led, and that was in mid-January. 3:55 And I'll find another five days, probably in April, 3:58 to keep on track about 3 to 4 times a year doing this. 4:02 But, you know, it just sounds too good to be true. 4:05 That you can eat, 4:06 but the cells think you're fasting, but your body gets the benefits. 4:11 It's like, you know, there's a million pitches in the world. 4:14 I mean, how many patterns, how many dollars from the National Institute 4:19 of how many behind this that make it so different than, you know, 4:23 so many things you can just flip through on social media? 4:26 Yeah. Doctor can you're right. 4:28 There's there's so just a lot of noise out in the nutrition space and 4:32 and how do you trust it. 4:33 Who do you trust. 4:34 And and I think we tried to do this 4:38 by conducting, clinical trials that are of the highest rigor. 4:42 And so far we, this technology we call neutral technology, of the FMD, 4:48 it has over 130 global patents. 4:51 So in longevity, cardiovascular diseases, diabetes, 4:55 blood pressure, cholesterol, autoimmune cancer. 4:59 And so these are we've filed over 250 patents. 5:02 And so far 130 have been granted. 5:04 And so we're still waiting for new ones to come. 5:07 I've also we talked a little bit about, you talked a little bit 5:10 about translational medicine, but what we've done is taken a step further. 5:14 Now we've started our 48 clinical trials. 5:18 And so I don't think there's any other nutrition company 5:22 out there that's been so committed to the science 5:25 and the facts of our products, and that's a commitment 5:29 we've made and will continue to make to to our customers. 5:33 It's really, really remarkable. 5:35 And as we were just discussing for a moment before 5:38 we put Ricardas, I like to read the literature. 5:41 I have my various ways to stay up to date. 5:44 And, you know, it's remarkable how many, 5:47 you know, studies come out in a 12 month calendar. 5:50 You mentioned one that's probably about two and a half years now. 5:53 I don't have it open right in front of me. 5:55 But biological age reversal, the fact that you judge 5:59 humans, you calculated not just their chronological age. 6:03 Anybody can do that after your driver's license. 6:06 But did testing on their biological age. 6:08 And what did they do? 6:09 They did the five day program three months in a row. 6:12 Yeah. 6:13 It's actually two different studies, put together in a publication. 6:17 One involved, three cycle of SMD three cycles.
Biological age reversal research 6:22 The other study was a four cycles FMD. 6:24 And when they this is actually a true story. 6:27 You know, we submitted initially to to the journal. 6:30 The journal didn't believe it because it was too good to be true. 6:34 They actually asked for the second study to be combined with the first study 6:38 to show more power. 6:40 And lo and behold, I mean, the second study showed exactly 6:43 like the first study that is just merely 15 days of effort. 6:48 Just remember, the FMD is a five day kit, right? 6:50 So if you do it three times, there's a total of 15 days. 6:54 It was associated with a two and a half year reduction in biological age. 6:59 Now what's biological age. 7:01 Well, it's it's a way of looking at how old your body is. 7:05 Without just counting the calendars, because you could do it. 7:08 And you and I both have seen patients who are, let's say, 50 years old, 7:11 but they're have a body of 45 or 50 year old. 7:14 They have a body of a 16 year old. Right. 7:17 And so chronological age is actually a bad marker for health. 7:21 And so this paper was published by Yale and, 7:25 UCLA and USC together in this journal called Nature Communications, show 7:30 that merely three cycles of FMD lowers biological age by two and a half years. 7:36 I mean, it was among the top three papers downloaded for that year. 7:41 So it was a very impactful, publication, you know, and probably 7:45 everybody listening would like a bit younger of a body, 7:49 as I'm in my 66 approaching 67 year, 7:53 I can't claim everything is exactly as, you know, 7:57 it was 20 years ago, and I'm sure everybody listening late. 8:00 So even just, you know, starting to turn the dial back 8:04 rather than racing forward, which would inevitably does 8:08 and, you know, racing and not doing it with a medicine 8:11 that is of questionable risk benefit ratio. 8:15 I mean, the risk benefit ratio, the 15 days of using the prolonged 8:20 systematic food program is so much favoring benefit in so much 8:25 not favoring risk that it's really low stands me how remarkable it is. 8:30 And then it is. 8:30 This is where, where I think it's, is when nature meets, science. 8:35 Right? 8:36 We we discover what happened in nature 8:39 and by understanding its mental pathways and how the cells actually work, 8:44 we're able to bring out what, what sort of mechanism of healing 8:49 there are deep seeded in our DNA and, and activates it right by, 8:53 by providing nutrition below the detection, of the cells. 8:57 And so this is where I really 8:59 see a beautiful story of how nature has designed the body to be. 9:03 And yet we are leveraging technology and science to bring it out. 9:06 Yeah, that's something everybody listening should become very, very, you know, 9:12 adept with and incorporate in their life would be my recommendation. 9:16 Let me just ask you about one more recent paper of the dozens. 9:19 And does that are, connected to all new trials?
Autophagy and cellular rejuvenation 9:23 And that's one that you were a prominent author on in December of 25, 9:28 the effect of fasting, mimicking diet, markers of autophagy and metabolic health. 9:33 And we're going to talk more about metabolic health. 9:34 But yeah, there are probably some serious students 9:37 of longevity and aging that know all about autophagy. 9:42 And the Nobel Prize in medicine. 9:43 But there's clearly some of us saying that 9:45 are not using the word autophagy on a daily basis. 9:49 Yeah. 9:49 Tell us a little bit about autophagy and a little bit 9:52 about this study that you were author on. 9:57 Yeah. 9:57 This is a really an age old question is, you know, 10:01 how does fasting actually what do they do? 10:04 How do we know it works? 10:05 And and this work is really building upon the, the Nobel Prize in 2016, 10:11 given to Professor Toomey for discovering autophagy. 10:15 And let me explain a little bit, you know, when when, when in the nature, 10:20 when a cell is starved with no nutrients, the cell has to survive. 10:23 So what does it do? 10:25 The life form has to figure out what inside the cells 10:28 can I burn to provide nutrients so I can live another day? 10:32 Because the food is not coming from the outside. 10:34 It's very simple. 10:35 And so over time, the cells have developed mechanisms 10:39 where they take out things that are less valuable, you know, 10:42 misfolded protein or the mitochondria or structures in the cells. 10:46 There are just not broken. 10:48 There are broken and not valuable. 10:51 The cells go by to to take in them and burn those components. 10:56 To do what? To generate energy. 10:59 So the cell to live another day. 11:00 And that's a survival mechanism triggered by this external stress of that food. 11:05 And so the cells actually recycles, these, these less valuable parts. 11:10 The when food, you know, always do reoccur again. 11:13 Right. 11:14 To happen in the nature food, the rain comes the food becomes available again. 11:17 Now the cells actually have to 11:21 produce new parts that is recycled earlier. 11:25 So what you're doing is essentially 11:27 taking the older worn out parts you replaced with new parts. 11:31 And now we're doing this under control environment, 11:33 because now we're sneaking the food in right 11:35 through the fasting mimicking die nutrition. 11:38 And so now you're getting the benefits of that cellular recycling 11:41 while you're getting the food, you're getting the nutrition. 11:45 What what ingenious way of triggering 11:47 the these, bodies, the ability to heal. 11:50 Right. 11:51 And but not not through brute force, but through science, 11:54 through sneaking those nutrition underneath the detection of the cells. 11:59 And this is the story of the fasting mimicking diet. 12:03 If somebody wanted to who's listening right now. 12:06 So I'm going to embark on this five day fasting mimicking diet. 12:11 And I want to run a test to prove I'm in autophagy and renewing my cells. 12:16 I don't think that's quite yet available. 12:18 Correct? 12:19 No, this is actually a really difficult, research to do. 12:22 We had to engage with, with, initially University of Texas 12:26 and this and this Cedars-Sinai, researchers 12:30 to test to to test for this, not not clinically available yet. 12:35 We had to run through a lot of essays and complicated essays like LS3, B2, 12:41 versus one, I mean, complicated, you know, enzymes and so on, so forth 12:45 that we believe in the future. It might be possible. 12:48 But what this also tells us is that we're committed to showing, 12:51 demonstrating the evidence and the science behind the FMD. 12:55 And in fact, in the study, we show that autophagy 12:59 begins to be triggered, probably after three days of fasting. 13:03 And so day four, it of that day four days, day five of the people 13:07 who are taking prologs show a very remarkable 13:10 signal of autophagy flux, which is really 13:14 what is a hallmark of active autophagy. 13:17 We related we were elated to to see the results. 13:19 And now in front of the world, we can show a definitively 13:23 that as you go through this five day FMD, the cells go through 13:28 cellular autophagy, rejuvenation and repair. 13:32 And I just want to stress for people listening, you know, 13:35 there are many studies 13:36 that are done on the desktop, many studies done in animal models. 13:40 This was human data. 13:41 So although, you know, you and I doing the five days as you 13:45 mimicking food is medicine program cat run a task for autophagy. 13:50 We have reason to believe that it is a reachable goal. 13:54 And as you said, if you're just skipping a meal a day, 13:57 there may or may not be benefit to you and your metabolic health, but it's this 14:02 five day program that triggers these remarkable changes. 14:06 Well, there's people listening right now then.
Clinical programs for metabolic health 14:08 No, they're not metabolically healthy. 14:10 Again, I threw out the number 80% have this cardiovascular 14:14 kidney metabolic syndrome. 14:16 Other data in the United States says 14:18 93% of Americans are not metabolically healthy. 14:22 And, you know, you oversee a tremendous program under the name El health. 14:27 And I really suggest everybody listening when we're done. 14:30 Dash Neutra health.com and go read about it. 14:34 But these are programs based around the five day fasting minimum 14:38 King diet to address head on using food, 14:41 prediabetes, diabetes, metabolic syndrome and other disorders. 14:45 Tell us a little bit about that branch, which is not going to be talking 14:49 about prolonged because we're not using commercially available bodies. 14:54 But ultimately, 14:56 there are plenty of people who want to use medication 14:59 to treat chronic diseases, but they're also a large segment 15:03 of the population says, hey, you know what, all these chronic diseases, 15:07 why do I keep taking more and more medications? 15:10 I'll need to? Health was born out of that. 15:12 That angle that the body has an ability to heal. 15:16 And we know when we combine FMD 15:19 together with principles of lifestyle medicine, 15:23 focusing on exercise, stress and everything else, all the behavior change 15:26 when you put it together, especially when is supervised by a physician. 15:31 Oh so supported by a dietitian. 15:33 Now that is a very comprehensive and safe program to reverse, chronic diseases 15:39 such as type two diabetes, high blood pressure, or hypercholesterolemia. 15:44 And that is the program that we build. 15:46 It's a physician supervised. 15:49 You have a dietician that is personalizing the treatment, but also incorporating 15:53 the Smt 15:54 at his core within intention to reverse age related chronic planning diseases. 15:59 So these are you know, we're not talking about theoretical cancer. 16:03 These are programs that people can enroll in 16:07 either they can initiate that by going to the website. 16:10 I have prediabetes. 16:12 My doctor says I type two diabetes. 16:14 My doctor says I have a metabolic syndrome problem, 16:17 that you can enroll, you can be coached, you can stay in six months. 16:21 There's diabetes type two reversal programs for 12 months. 16:26 And they're available right now. Right. 16:28 That's that's absolutely right. 16:30 And sometimes, you know, we know that, you know, 16:33 if you just eat well and exercise well, you could achieve better health. 16:37 But the reality is it's difficult to do. 16:40 As can see, our program really understands 16:42 the pragmatic challenge of being living as a saint. 16:46 And so we try to use these neutral technology approach sets such as the FMD. 16:52 And especially, you know, combining high tech with high touch 16:56 delivery through a dietitian that can personalize to your need. 17:00 This is where we can treat the root cause of these conditions. 17:03 And in the hopes to reversing it. Wow. 17:06 And you have published data 17:09 on the impact of being involved in a program like this. 17:13 You know what? 17:14 What on average happens a hemoglobin A1, CA3 month marker, a blood sugar control. 17:19 What happens with medication lists in people, you know, rolling. 17:25 There are two different levels of evidence. 17:27 One is clinical trials. 17:28 And the clinical trials, run at a universities where you show, 17:32 for example, six months, but you pray to about 1.4 17:35 you once you drop, which is really impressive. 17:38 And in in those studies, about two thirds, 17:41 the people were able to experience a drop in medications. 17:44 And that's what a lot of the patients, while they want 17:47 freedom from the burdens of taking multiple medications, 17:51 now, the second level evidence would be what we call real world evidence. 17:54 In fact, we we presented the American Diabetes Association 17:58 last summer, from 200 of our diabetic, 18:02 patients in the program, which again, we show people, lot about, 18:07 about 10% of their body weight with less medications. 18:10 Again, about two thirds of the people, 65% of the people to 70% of 18:14 the people were able to reduce their diabetes, medication dependance. 18:19 And at the same time, blood pressure medicine was also decreasing. 18:23 There were losing weight, but they were maintaining muscle. 18:26 And that was a key point here. 18:28 I think this is not everyday weight loss, right? 18:30 It's a five day interventional nutrition that that was portable. 18:34 And then there's according to a protocol, 18:35 it's almost like a drug except it's actually nutrition. 18:39 And the results are astounding right. 18:41 People are distress. 18:42 The decreased of living with this condition. 18:45 It was improved less medications they lost. 18:48 People maintain muscle. 18:49 And that's exactly what we see as a better picture of health. 18:54 When all these parameters improved. 18:57 I'm just browsing as 18:59 we're talking the Al Neutra health.com, website. 19:03 And there's a tab called science. 19:05 I always like to go to tabs like that when I'm looking at a product website 19:09 or a educational website and just literally dozens of research papers 19:15 about weight loss, blood sugar control, preservation of muscle mass, 19:20 obviously the competitor out there is the pharmacologic approaches. 19:25 And certainly the GLP one class of drugs and related drugs. 19:29 But, you know, we all share this concern. 19:31 We don't really know very long term. 19:33 It's the exact opposite. 19:35 Our food is medicine. 19:36 It's, you know, stop eating food might be medicine. 19:40 It certainly is concerning about the, you know, the ratio of visceral 19:44 fat loss, subcutaneous fat loss and somatic muscle loss. 19:48 None of us want to necessarily end up frail. 19:52 But in the case of a person who has that hemoglobin 19:55 A1, C of 6.9 and maybe their endogenous says, 19:59 look at I read the literature of if we have your hemoglobin A1, z under 7% 20:05 and you're stable, that might be a reasonable end point. 20:08 Now that's still solidly type two diabetes, causing 20:13 probably nerve damage, arterial damage, chronic kidney damage, eye damage. 20:19 It's not normal. 20:20 You know, that person facing the choice of a GLP 1st May be self-pay, 20:25 may be insurance approved versus 20:28 getting involved in in a neutral outcome. 20:31 I mean, what have you seen? 20:32 What are your observations? 20:34 What are you doing in the clinic? 20:36 I think for too long, patients and clinicians have settled 20:39 for management, chronic management of of diseases. 20:43 Right. 20:44 Take 3 or 4 different medicines for blood pressure, you know, 1 20:47 or 2 medicine for cholesterol, maybe 3 or 4 different drugs for diabetes. 20:51 We settle because we've been too low. 20:55 You know, we just want to control symptoms and signs. 20:58 What we're seeing through the program is by addressing cellular aging, right. 21:03 And lowering the biological age by really driving cellular autophagy. 21:07 That's renewal on the level of the cells by really reprogram
Real-world outcomes and patient support 21:11 metabolism where you're losing fat preserving muscle. 21:16 But they are addressing these root cause. 21:17 What we're seeing in the program is 21:19 people are reducing their dependance on medications. 21:23 They're really reprograming their metabolism. 21:26 And this is where we're shifting from 21:29 from a secure model, truly, to a health care model. 21:34 And I believe that there are listeners out there. 21:37 They're looking for that kind of solutions. 21:39 And we provide the evidence that is safe and efficacious. 21:43 And, we would like to be part of your health care solution. 21:47 And again, I 21:48 really encourage everybody to look at what I consider the most scientific food 21:53 is medicine program called Dash Neutra and Neutra health.com. 21:58 I'm under a tab right now that says there's two programs, 22:03 the Diabetes Remission and Regression Program, a 12 month 22:07 coached program using the five day diet program. 22:11 And then there's one for cardio metabolic health. 22:14 You're not a type two diabetic, but you're in that great mass of Americans 22:19 and people living in a Western country that, lab work is 22:23 just disappointing, and you're stuck and you're looking for a solution. 22:26 And here is, again, the most science backed solution. 22:30 So you are enrolling new people. 22:32 If somebody were to reach out via the website, they could get in to. 22:37 Absolutely. 22:38 We are increasing the capacity because more and more people are really 22:42 looking for a non-pharmacological approach to chronic diseases. And 22:49 we're ready for you. 22:50 All right. 22:51 And I understand that people that are involved in the reverse 22:55 to diabetes type two diabetes program now, once a quarter, 23:00 you do a Q&A for them, which is very kind of you. 23:04 I think education and then empowerment is really part of the story. 23:07 And so, I also meet with them one on one as well. 23:11 And and, and quarterly engagement Q&A sessions where I present 23:16 the science and the publications, they're just increasing dialog. 23:19 And I believe that when people increase their knowledge, they feel empowered 23:24 and they'll have more strength 23:25 and more motivation to take care of their own health. 23:28 Yeah. 23:29 And just so people remember, if you get involved in this program 23:33 and one of the perks is contact with doctor Hsu. 23:36 Yeah. 23:37 I mean, the former Chief Joslin Diabetes Center, a board certified endocrinologist. 23:43 You know, it's not usually the kind of access 23:46 you get when you pick up a juice back at the local, 23:50 you know, organic store, and you're making some effort on your health. 23:54 This is a whole new level beyond it. 23:56 I heard about prolong and Al Neutra in 2008. 24:00 Light bulbs went off and very fortunately 24:03 attended a conference in USC and met Doctor Longo in the team. 24:07 And I have done this program, 24:09 so many times, and it's only getting better and better. 24:12 I just keep asking, can I buy the crackers? 24:15 I'm sure lots of people say, I can I get the alma, you know, unfortunately, 24:19 we've got a nice array of products under the proline name. 24:23 But again, you remember the sizing. 24:25 We're talking reversing disease. 24:28 It's the L neutral outcome site you want to go to. 24:31 So I appreciate you taking the time. 24:34 I'm sure it's always such a pleasure and an honor to speak to you. 24:38 And, the company is just exploding with such great science. 24:42 There's new papers. 24:43 We haven't even talked about the made headlines around the world and last month. 24:48 But we'll save that for a future interview, if that's okay. 24:52 That's 24:52 kind of thank you and appreciate that. 24:55 Or you bet, sir. 24:56 And stay warm. Thank you.
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