Full Transcript Introduction to CoQ10 and PQQ 0:00 All the antioxidants are great, but CoQ10 is just not only an antioxidant. 0:05 It is running your energy production and defending your cells at the same time. 0:08 That makes it very, very unique. 0:10 At the mitochondrial level, it simply is doing something different than other antioxidants. 0:14 it also is fat soluble and most antioxidants, including the master antioxidants, glutathione, are water soluable. 0:22 They do beautiful work in the parts of the cell where water soluble antioxidants work, but that's not where CoQ10 works. 0:30 It works in fatty membranes where an enormous amount of oxidative damage actually happens, including the membrane of your mitochondria and the surface 0:40 of you LDL particles. 0:42 Welcome to Vitality Radio, the podcast that helps you make sense of natural supplements and thrive without pharma drugs. 0:49 I'm Jared St. 0:50 Clair. 1:05 Hello and welcome to Vitality Radio. 1:07 I'm Jared St. 1:08 Clair. 1:08 It's good to be with you again. 1:10 Before I get into this, I want to thank a listener named Jackie. 1:21 because this whole episode is her idea. 1:23 So Jackie, thank you so much. 1:24 She wrote in and asked me to break down CoQ10 for her, asked if there was an episode, and I thought there isn't an episodes, 1:30 but there probably should be. 1:32 And I'm always looking for episode ideas. 1:33 If you have an idea, jump online, vitalitynutrition.com, open up a chat and say, Jared, tackle this one for me. 1:40 I won't always do it. 1:41 It depends on the episode and if I think it's something that's got some universal appeal. 1:46 This episode is interesting. 1:47 We're talking about coenzyme Q10 and also PQQ. 1:51 I'll talk about what those two things are. 1:56 And I'll explain to you why I think if, even if you're thinking, ah, any oxidants, CoQ10, I don't really need to hear about this. 2:01 Why this is a topic that I Think everybody does need To hear. 2:06 So like I say, if You want me to dig into something like this, please do. 2:10 I've been getting some great recommendations lately and I have done three or four shows based specifically on listeners like you saying, 2:17 Hey, Jared, i want to Hear more about This. 2:19 Let's talk about molecule Coq10 because I'm old enough to remember when Co Q10 wasn't a supplement. 2:26 But guess what? 2:27 It's always been a thing because our body actually makes this stuff and you've heard of it. 2:33 You've seen it in mass retailers. 2:35 That's in Costco about twice a year. 2:38 I go into Costco and I get this shuddery feeling like, oh my gosh, they've got all their supplements on deal and they're all up front and there on some 2:46 crazy price and it looks really appealing and some of their Supplements are fine and others of Their supplements are like And I've done shows on walking 2:54 through the Costco supplement aisle. 2:55 In fact, we'll link that episode. 2:57 Fact, I probably need to do another one because they're recycling things through there all the time and talk to you about which ones I think are fine and others, 3:04 which I. 3:05 We don't want to spend our money on because remember the biggest thing with Costco is this. 3:09 They're always looking to give you the very best price on the thing. 3:14 And when it comes to paper towels, that's a pretty useful thing when Most people are taking it because they're worried about cardiovascular wellness and 3:32 most people who are worried because it kills about a third of Americans.
What CoQ10 Does in the Body 3:36 So of course it's something that we should be concerned about. 3:39 But you know why else a lot of people take CoQ10? 3:41 Because they are on a statin drug and you may be one of those people and statins prevent the body from making CoQ10 or at least at its optimal dose. 3:51 So let's talk about this whole thing because there's this internal factory producing this thing. 3:57 And that's a theme that you'll hear from me often during our shows that a lot of what I talk About is stuff we can't get from inside our body. 4:04 We got to get it exogenously from outside and other stuff. 4:07 This stuff, we just don't make as much as we used to. 4:10 Maybe that is a hormone or maybe it's something like Coq10. 4:14 But CoQ10 sits right at the center of how your cells turn food and oxygen into usable energy. 4:23 And your ability, unfortunately, like so many things in health, peaks somewhere in your 20s and then slides downhill from there. 4:32 By the time you hit your late 30s, your 40s into your 50s your internal production has already dropped off meaningfully. 4:38 And that decline shows up first in the tissues that need the energy most, which is your heart, you brain, and your muscles where so much ATP is used. 4:49 There's a second wrinkle and it's big one. 4:51 And that's the one I mentioned about so many Americans taking statin drugs for cholesterol. 4:57 And, that drug actively works against your body's ability to make CoQ10. 5:02 So, today, I want to give you the real education on a few things. 5:06 What Coq10 actually is and why it matters. 5:08 Why does our body make it in the first place? 5:10 And what does out body do with it? 5:12 What's a difference between ubiquinol and ubiquinoe? 5:15 If you're familiar with CoQu10 and you've seen these two things, Sometimes they look interchangeable. 5:20 They're not. 5:21 We'll talk about that. 5:22 How to tell if you're getting a natural one made through a fermentation process or a synthetic one, made out of tobacco, 5:29 believe it or not, or potatoes. 5:32 And where PQQ fits into all of this. 5:35 If you've not heard of P Q Q, PQQ is pretty fascinating stuff. 5:39 And why I finally decided on the seventh version of Ultimate Vitality Multi to include both of these ingredients in the multivitamin and whether or not 5:48 the amount that's in there is good enough for what you're trying to do with CoQ10. 5:51 So that all ahead. 5:52 Let's get into Coq10, let's build this from the ground up because once you understand the mechanism, everything else in this episode should click into place. 6:02 Co Q10 is a fat soluble compound found in membranes of your mitochondria. 6:07 Boy, do we hear a lot about mitochondria nowadays, right? 6:10 This is the little energy plant inside your cells. 6:13 We all have heard of this, and lately, if you're listening to a lotta shows like Vitality Radio, you've heard about it a LOT. 6:18 You've got hundreds to thousands of them in a single cell, in an hard-working cell like a heart muscle cell. 6:27 Inside those mitochondria, there's an assembly line called the electron transport chain, and that assembly is where the real energy of your body gets made. 6:35 A molecule called ATP, adenosine triphosphate, which is the actual currency your cells spend to do everything that they do. 6:43 make your heartbeat, contract a muscle or filter your blood. 6:47 CoQ10's job on that assembly line is to be the shuttle. 6:52 It carries electrons from one station to the next. 6:54 Without it, the line stalls and ATP production drops. 6:58 So this isn't a nice to have nutrient that gives you a little boost. 7:01 it's a non-negotiable part of the machinery. 7:05 That's why your body bothers to manufacture it in the first place. 7:08 It's too important to leave to chance in the diet. 7:11 And it's why so many people actually start taking CoQ10 in their 30s, 40s 50s because they're noticing a significant drop off in a lot of these areas, 7:19 especially cellular energy. 7:22 Now here's the part that makes Coq10 special though. 7:25 This is the theme that I want you to carry through with me through this entire show because it wears two hats. 7:32 Hat number one is the one I just described, the bio-energetic, co-factor, central to making energy. 7:38 But hat number two is that it's a genuine antioxidant and it is often called one of the kings of antioxidants. 7:46 While it sits there in your membranes doing this energy job, it also neutralizing free radicals, unstable molecules that damage your cells and lead to 7:55 aging and oxidation. 7:57 It also helps to protect against the oxidation of your cholesterol itself. 8:02 which is a big deal, and we'll talk a little bit more about that when we talk about statins, the unstable molecules that damage your cells, 8:09 including the oxidation of your cholesterol particles, which we will talk more when talking about CoQ10 and statin drugs. 8:18 So this is a big deal for a lot of reasons, but two in particular, cellular energy and prevention of oxidation of the cells and the free radical damage 8:30 that happens there. 8:31 Because it's fat soluble, it makes it different than a lotta other antioxidant, concentrates in the organs that are the most metabolically demanding and 8:41 most membrane rich. 8:42 Your heart carries the highest concentration in your entire body. 8:46 That's no surprise. 8:48 because your heart never gets to rest. 8:50 Then your liver, then your kidneys, and your brain. 8:52 These are engine room organs. 8:55 They are the ones most exposed when your CoQ10 runs low. 8:59 And when you think about these things, liver kidney, brain, heart, pretty critical organs, right? 9:05 And it does run low. 9:07 Your natural production peaks young and declines with age. 9:10 Like I mentioned before, certain kinds of physical stress and certain medications pull it down even further. 9:15 So you have this essential dual purpose molecule that your body makes plenty of when you're 25 and noticeably less when your 50. five or 54 like I am. 9:27 That gap is the whole reason that we're having this conversation. 9:31 Now, there's two forms of CoQ10 out there, really three, but two primary forms and it gets confusing because it's kind of like vitamin C. 9:40 You've got Mineral ascorbate forms of vitamin C like we have in vital C and then you've got just ascorbic acid and they even have like liposomal vitamin 9:47 c They're all vitamin. 9:48 C, but they're different versions, right? 9:50 That's kind of how this is with coq10 There's ubiquinone and ubiquinal Now I say i'm old enough to remember when ubiquine known first came out co q10 I'm 10:00 also old. 10:00 Enough to remove when you pick when all came up But that's a much more recent thing and not a more recently discovery We'll talk about the difference between 10:07 those two but a More recent discovery in terms of how to make it so that we can take it as a supplement. 10:15 Now, if you walk into a store like Vitality Nutrition or you're scrolling around online at vitalitynutrition.com or some other website that sells supplements,
Ubiquinone vs. Ubiquinol 10:24 you'll see ubiquinone and ubiquinal and oftentimes both of them will say CoQ10 on the label. 10:31 and you'll usually see that there's a significant price increase between CoQ10 ubiquinone and Coq10-ubiquinol. 10:39 They are two forms of the exact same molecule and the difference comes down to a chemical state that that form may be found in. 10:47 Ubiquonone is the oxidized form, ubiquinal is reduced form meaning it's carrying a couple of extra electrons. 10:55 And here's the important part. 10:57 Inside that electron transport chain that I described, your body is constantly flipping this molecule back and forth between these two states. 11:06 Ubiquinone picks up electrons and becomes ubiquinol. 11:10 Ubiquanol drops them off and become ubiquanone over and over, thousands of times. 11:17 That flip is the actual work. 11:19 Both forms are real, both are useful, and your bodies needs the ability to cycle between the two. 11:26 When you take either one, your body can use it. 11:29 Take ubiquinone and a healthy body will convert a good portion of it to ubiquinole. 11:34 It's already in that reduced antioxidant ready state in the bloodstream of a health person. 11:40 Roughly 90 to 95% of the CoQ10 circulating is actually in ubiquinal form. 11:47 So that's the form the body prefers to keep on hand. 11:49 Now, it's not the same as like a methylated B vitamin, but it kinda is the thing. 11:54 Basically, the ubiquinol form has already had the work done. 11:59 And you'll learn here in a minute that age plays a major role in this as well, in terms of how well your body can make ubiquinol from ubiquinoe versus 12:07 just giving it ubiquinal in the first place, making the job much, much more simple. 12:12 Now, the practical question is, which one do you buy, right? 12:17 And this is what I believe you need to understand. 12:19 It's not a hard yes or no on ubiquitone versus ubiquinyl. 12:25 For a lot of people, especially if you're younger, I would say under 40 for sure, but even under 50 or 60, there's evidence that ubiquinone may be good enough. 12:35 But you have to ask yourself a couple of questions. 12:37 If your digestive system is in pretty good shape, things are humming along that way. 12:43 And like I say, you're under 60 for sure, but under 50 or under 40, even more so. 12:48 Ubiquinone, much less expensive, probably a very effective and efficient way to do this. 12:54 You also need less of it when you are under forty than when your over 40. Because again, your peak is about 25 years old. 13:00 So really anybody over 25 would probably benefit from some CoQ10. 13:05 We'll talk a little bit about that when we go into my multivitamin here in a minute. 13:11 If you're older, like me, I'm 54, so I would consider myself right at that borderline. 13:18 I think maybe 50 is the number that we should look at based on the research that I've done. 13:23 That over 50, ubiquinol is probably the optimal one to do. 13:28 Not that it's not better to use ubiquinal at a younger age. 13:31 In fact, if you are looking at it and saying, you know what, not too concerned about the difference in cost, which some people are, 13:36 some aren't, get it, supplements can get expensive, And this is why I'm having this conversation. 13:41 So otherwise, just I just say ubiquinols better buy it. 13:44 But I don't think everybody needs it necessarily. 13:46 And in fact, I included ubiquine known in the ultimate vitality multi because it's less expensive and I didn't want to drive the price of the multi higher. 13:55 There are a lot of people that use that multivitamin that are under 50 years old that maybe don t need that different form. 14:00 Right. 14:00 We'll talk about that again. 14:01 I m jumping ahead a little bit here. 14:03 Getting into the multi, but let's talk about this thing because cost matters and ubiquinol. 14:09 It's like double the cost in most cases, uh, somewhere close to that. 14:13 Anyway, I didn't actually look at it before we started to make exactly sure, But I think it's around that double ish price. 14:19 So I would say if you're under 50. and your gut is in pretty good shape, I would probably take ubiquinone, save the money, 14:26 get an optimal dose, and we'll talk about what an optimum dose is here in a minute. 14:30 If you're over 50 or if you are under 50 and you have a lot of gut issues, you may want to consider ubiquinole because ubiquinal is much more easily absorbed. 14:39 Your gut doesn't have to do as much work, so that's the gut side of it, you tend to just need more of the more usable form. 14:48 And there's evidence showing that people over 60 really benefit from a ubiquinol form versus a Ubiquinone form, so you just have to figure it out based 14:57 on that. 14:58 Under 50, good digestion, Ubicuinone, over 50 or bad digestion or both ubiquinol. 15:05 That's probably the easiest way to look at it. 15:06 CoQ10 can be produced two fundamentally different ways. 15:10 The first is a natural fermentation process. 15:12 Some of the best things in life are made through natural Digestive enzymes, systemic enzymes things like not all kinase, 15:21 so many wonderful things. 15:22 CoQ10 is not different that way. 15:24 You take specific forms of yeast and let them ferment and those yeast produce Coq10 as part of their own biology the same way that your cells produce it. 15:33 So that's the natural form, the closest thing to a bio identical and that is called the all transform of Co Q10. 15:42 That's a description of the molecule's shape, its actual geometry. 15:46 And it matters because the all-trans shape is the exact shape your own body produces, so it is bioidentical. 15:53 At the cellular level, your body recognizes it without any hesitation. 15:58 The second way is chemical synthesis. 16:00 Historically, this has been done from petroleum-derived starting material. 16:05 which is awful, or from a compound called Solanusol, which has pulled from tobacco stems and potato leaves, interestingly enough. 16:14 And it's built up through a chemical process in a lab. 16:17 The problem isn't just where it starts, because where is starts is not necessarily great, especially the petroleum option, 16:24 but it is what you end up with. 16:25 Synthetic production creates a mixture of shapes You get some of the correct all-trans form, the bioidentical stuff, but you also get the mirror image 16:35 known as the cis form which does not exist in nature and which your body did not evolve to use. 16:41 Cheaper synthetic material can carry a meaningfully High percentage of that unusable form, your body simply doesn't recognize and utilize those the way 16:52 that it does the natural shape. 16:54 So you paid for a certain number of milligrams, but a chunk of what you swallowed is a shape that your. 16:59 Doesn't even know how to use. 17:02 natural, fermented, all trans is the gold standard. 17:05 And there is a dominant name in the world for CoQ10, and that is called Kanika, a Japanese company. 17:11 It's K-A-N-E-K-a. 17:14 Now, most of what you see on the market will not say Kanik in bold print right on front of the label. 17:19 Some of it does, somewhere on in front on label, but it's going to say the brand name, right? 17:23 Solar Ray, Natural Factors, companies like that. 17:27 And then oftentimes it'll say Kanika lower and have a little symbol showing you there, or on the back in the supplement facts panel,
Natural vs. Synthetic CoQ10 17:34 it will say it's from Kanica. 17:36 Or sometimes it would say, It's all transform. 17:38 or sometimes It'll saying naturally fermented. 17:40 You're looking for some tell on label that tells you one of those things. 17:46 If it doesn't say any of things, a brand is not going to not brag about their quality of CoQ10. 17:53 If it doesn't say it's all trans, if it doesnt say its from Kanika, who is the pioneer in all this and makes the best CoQ10, 18:03 and it dosnt' say, or it doens't' naturally fermented, then you've probably got a synthetic Coq10. 18:08 So look for one of those things. 18:10 All trans. 18:11 Naturally fermented. 18:12 Kanica. 18:13 One or more of these things is what you want to see. 18:16 All that we carry at Vitality Nutrition, period, is that form. 18:21 We do not carry the synthetic form, I never have, and never will. 18:25 It is cheaper and you can get it on grocery store shelves, you find it at places like Costco and Walmart. 18:30 You don't want it. 18:31 So, don't waste your money. 18:33 Even if it's 20 or 30% cheaper, it is probably significantly less effective than that. 18:38 So that's what you're looking for when you are looking at CoQ10 in terms of quality. 18:43 Now, what about potency? 18:44 What's been studied? 18:46 And let's talk about this dosing thing because it's really important and it probably, well, the two most common things that I hear from people when they're 18:56 curious about CoQ10 is how much should I take and do I want the ubiquinol ubiquinoin form? 18:59 So we already talked about ubiquinal ubiquine and hopefully I made that clear enough. 19:03 The dosage is a little bit more tricky because depends on what you're taking Coq10 for. 19:07 I don't consider CoQ10 part of my vital five because I think everybody needs it, especially younger people as we discussed. 19:13 But it is one of those things that's a really powerful potential game changer in overall health and longevity for a variety of different reasons. 19:22 And so it should be on your list of things to at least consider as a preventative maintenance thing. 19:26 There are certain things it's very specifically good for, but the dosage really matters here. 19:32 So think of it in two tiers. 19:34 There's a foundational tier, the amount that supports just healthy energy production and antioxidant defense day to day for generally healthy adult who 19:42 wants to keep the tank topped off as their own production declines. 19:45 Who wants a powerful antioxidate to help with all the things that antioxidants help. 19:50 And that dose can literally be anywhere from about 30 milligrams, which is what I included in the Ultimate Vitality Multimedia. 19:55 All the way up to 100 or even 200 milligrams. 19:58 I think 30 to 100 milligrams is a good dose for just kind of basic foundational support and with a fat soluble fatty meal. 20:08 But then there are reasons why you might want to take a lot more than that. 20:11 The targeted tier would be things like cardiovascular health and cardiovascular disease. 20:18 In 2014, University of Copenhagen followed 420 people with significant heart challenges over two years. 20:24 They took 100 milligrams of CoQ10 three times a day. 20:27 So 300 total milligrams, of ubiquinone, on top of the standard care. 20:31 And the results were the kind that make cardiologists sit up and pay attention. 20:35 The group taking Coq10 had roughly half the rate of major cardiac events compared to the placebo group. 20:42 and about half the mortality. 20:44 9% of the people on CoQ10 died over those two years versus 17% on the placebo. 20:51 Their symptoms and their physical capacity improved right along with it. 20:54 This dose was 300 milligrams of ubiquinone specifically in people with cardiovascular challenges. 21:03 So these are people presumably with previous cardiac events, that sort of thing. 21:09 Then there's a piece of work that came out of Sweden published in 2013 the year before that paired 200 milligrams of CoQ10 with 200 micrograms of selenium 21:18 in a group of healthy older adults and followed them for about four years. 21:23 Pairing these two is clever because selinium feeds the enzymes that help keep Coq10 in its active ubiquinol form. 21:31 The result, the supplemented group had more than 50% lower cardiovascular mortality than the group taking placebo. 21:39 So almost exactly the same results, but over even an extended period of time. 21:44 And the part that genuinely struck me, when the researchers went back and checked years after the supplements had stopped, 21:50 that protection was still showing up more then a decade later. 21:54 That's a remarkable finding for two nutrients that you can get in a health food store. 21:59 Think about that. 22:01 So they took it for four years, but they had protective benefit for at least 14 years. 22:07 really, really impressive.
Dosage, Research, and Statins 22:09 It means to me that any CoQ10 is better than no Coq10. 22:13 And of course, consistent use would be the best of all worlds. 22:17 Higher potencies have shown up in other studies as well. 22:19 In 2005, in the University Hospital Zurich in Switzerland, 300 milligrams, again, a day was used with people dealing with recurring neurological head pain. 22:29 and there are other studies on migraines specifically as well. 22:32 And about 48% of the CoQ10 group cut the frequency of those episodes at least in half. 22:38 So about half of people got about 50% reduction in frequency versus only 14% in the placebo group. 22:47 Coq10 also runs all through the fertility research, where higher doses have been studied for egg and sperm quality, both situations where the energy demand 22:58 inside the cell is enormous. 22:59 That's the through line across every one of these. 23:02 Harder working tissue has to work. 23:05 And CoQ10 helps that tissue work harder at higher than the normal hundred milligram dose that we talked about or 30 milligram does that. 23:13 We talked. 23:13 So if you've got a cardiovascular concern, whether it's family history or actual history of your own, then Coq10 yes, 300 milligrams minimum. 23:22 And I would use that exact same strategy that I talked, depending on your age and your gut health. 23:27 whether you take CoQ10 as ubiquinone or ubiquinal. 23:30 If I personally were dealing with cardiovascular concerns, I would take ubiquinole period because it's obviously the best form and a heart attack or a 23:41 stroke can be the end, right? 23:42 So we don't want to mess around with it. 23:44 But if you're in the more preventative range, then ubiquine owner, ubiquina based on those criteria that I mentioned earlier. 23:51 And if your dealing head pain, migraines, neurological headaches, things like that, definitely worth a shot at 300 milligrams per day to see what it can 24:00 potentially do for you there. 24:01 Now, let's talk about this statin piece. 24:02 I don't want to go into too much detail here, only because I just did a whole show on statins. 24:06 And I'll refer you back to that episode in the show description as well. 24:10 But let just talk this so you actually understand the mechanism, because a lot of people know that statens reduce CoQ10. 24:16 That's actually, in fact, there are even cardiologists to their credit, even though they're still recommending statans, which I strongly disagree with, 24:22 that are also recommending at least Coq10 along with it. 24:25 They are the most prescribed drug in the country. 24:28 And then understand how they interact with CoQ10. 24:30 You just have to understand, how do they work, period. 24:32 Statins lower cholesterol by blocking an enzyme in your liver. 24:35 That rate limiting step of something called the mevalinate pathway. 24:40 that pathway is the production line your body uses to build cholesterol. 24:44 Block that enzyme, you make less cholesterol, which is exactly what the drugs are meant to do. 24:48 But guess what? 24:49 If you block the Mevalinate pathway, It's also how your body makes CoQ10. 24:54 They branch off of the same road. 24:56 So when a statin shuts down that early step, it doesn't just turn down cholesterol, It turns down your bodies own manufacture of Coq10 right along with it. 25:03 And we just talked about this, how protective of cardiovascular system and the heart specifically Co Q10 actually is. 25:12 So it's just like when they prescribe diuretic drugs for heart disease or for high blood pressure and that leeches more potassium out of the body, 25:23 more magnesium out the electrolytes out which leaves the heart more exposed. 25:27 It's the same thing with CoQ10 and cholesterol and cholesterol drugs. 25:33 Here we are trying to prevent heart disease with a statin drug by depleting perhaps the most protective antioxidant for the cardiovascular system. 25:45 So while I'm not your doctor and I am not the guy that says don't take these drugs, Well, I am the guy that says don't take these drugs, 25:51 but I'm not your doctor. 25:53 So I not saying that to you specifically. 25:54 I just generally saying I hate statins. 26:12 Gotta be on CoQ10. 26:13 It's as simple as that. 26:14 And I would recommend, again, all the criteria I mentioned earlier, which Coq10 you decide to use. 26:20 I'd recommend a minimum of 200 milligrams, and I actually think optimal is probably in that 300 milligram range, maybe even 400 milligrams. 26:29 There is some research, not as compelling because it's mixed on Parkinson's disease and slowing down Parkinson disease at high doses, 26:38 like 1200 milligrams of Co Q10, My dad had Parkinson's disease. 26:42 You may know I saw the withering effect of that disease that is brutal. 26:46 I wouldn't wish it on anybody. 26:49 And we don't know how effective CoQ10 is there, but I think if I were to deal with that, I would definitely at least give it a shot. 26:57 But the research is very mixed on that. 26:59 Whereas all of these other things are much, much more clear. 27:02 All right, so basically that's CoQ10, ubiquinone, Ubiquinol, which one, how much, all of that. 27:09 And then there's one more ingredient that is like besties with Coq10. 27:12 It's called PQQ. 27:15 Piroloquinolinequinone. 27:21 That's why they're called pqq. 27:23 it's found in foods like parsley, green peppers, Green tea, Kiwi and papaya. 27:28 and unlike Co Q10 your body does not manufacture it. 27:32 So if you want to get it, you gotta get into your diet or you got to supplement it. 27:36 CoQ10 works inside your existing mitochondria as we discussed. 27:40 PQQ does something Coq10 does not do, but that is clearly related to what Co Q10 is doing for your body. 27:48 Research was first published in 2010 on this because it is really a new discovery. 27:52 I never heard of Co P Q Q until about 10 years ago. 27:55 But the research is really cool. 27:57 This was done in the Journal of Biological Chemistry out of the University of California, showed that PQQ can actually stimulate the creation of brand 28:07 new mitochondria. 28:08 There's a technical term for this, mitochondrial biogenesis, but we're talking, it makes mitochondrion. 28:15 That is really impressive stuff. 28:17 PQQ helps to switch on the cellular machinery that builds new energy plants. 28:23 It works through a master regulator inside the cell, a signaling protein that tells the cells, make more mitochondria. 28:29 If you put those two facts side by side, you see why they're such a great team. 28:33 CoQ10 makes your current mitochondrial run better and it defends them. 28:37 And Pqq helps you build more of them and protects them too. 28:42 One optimizes the factory you have, the other one helps you open up new factories. 28:48 That's real synergy, not two things that happen to be marketed together, but two that work on different parts of the same problem. 28:54 And that problem, declining mitochondrial energy as we age is arguably one of most important stories in how we feel decade to decade. 29:05 On the human side, the cognitive research is where PQQ gets interesting. 29:09 In studies on middle-aged and older adults, Me? 29:13 20 milligrams of PQQ a day over about 12 weeks supported measurable gains in memory and attention compared to a placebo, 29:22 which tracks because your brain is one of those enormously energy-hungry organs that lives and dies by mitochondrial function. 29:30 And here's a detail that I love. 29:32 In some of that research, when they combined Pqq with CoQ10, the two together outperformed P qq on its own. 29:39 Different tools, same goal, better result when they work side by side. 29:44 So there's a branded form of PQQ called Bio P Q Q made in Japan through a natural fermentation process. 29:51 But, oh, and I forget to mention this, this is really important. 29:53 Almost all ubiquinol is naturally fermented. 29:57 Still look for that on the label. 29:58 Look for the Kanika, all that stuff, but there is not much synthetic out there. 30:03 And the same can be said about PQQ. 30:05 So you're not as worried about pqq, you are not worried as much about ubiquinol being synthetic, but you always just looking for a reputable brand like 30:14 Natural Factors, Solare, Vitality Nutrition, making sure you getting a high quality version of these things.
PQQ and the Antioxidant Team 30:20 So why would I select CoQ10 over other antioxidants if I'm just looking at it as an antioxidant? 30:25 I am not necessarily overly concerned about my cardiovascular wellness. 30:30 It's a little bit of a tough one, but I will tackle it because I think it's important and it is a common question. 30:35 Glutathione, Vitamin E, vitamin C, resveratrol, grape seed extract, azazanthin, zeaxanthan, lycopene, lutein. 30:44 So many antioxidants. 30:46 And it's not a competition. 30:48 There isn't really a winner and a loser here. 30:51 The antioxidant system is a team and the more antioxidants really the better. 30:54 But CoQ10 does hold a few positions on this team of antioxidants that others simply can't play, which is why I elevate it towards the top of the list as 31:04 antioxidants go. 31:05 And that's why it is one of these antioxidants, that is now in the ultimate vitality multi along with lutein and zeaxanthin, 31:12 and of course PQQ. 31:14 and we put 10 milligrams of PQQ in the multi. 31:17 which gives you half of that clinical dose, because I think at any age, 10 milligrams makes a ton of sense. 31:24 And if you want to take additional, now you can take half as much, take an additional 10 milligram. 31:28 Most PQQ on the market is a 10-milligram Pqq. 31:33 I noticed that when I was formulating the Ultimate Vitality Multi. 31:36 So I thought, well, this will keep people basically spend half-as-much money on your P Q Q. 31:40 If you decide that you wanna use P q q plus the ultimate vitality multi, which is what I'm doing, as of developing the new Multi and deciding to do this 31:51 episode on CoQ10 and PQQ, I am now a new user of extra Coq10 PqQ. 31:56 I was not someone using it before, but I've been converted. 31:59 And my wife and I now are both utilizing Co Q 10 and p q q and using a little less of the P Q. 32:05 Well, half as much of P q Q because of what's in the ultimate vitality Multi. 32:09 But I digress. 32:10 So I talked about the competition. 32:12 There isn't a competition, all the antioxidants are great. 32:15 But CoQ10 is just not only an antioxidant. 32:20 It is running your energy production and defending your cells at the same time. 32:24 That makes it very, very unique. 32:26 At the mitochondrial level, it simply is doing something different than other antioxidants. 32:30 it also is fat soluble and most antioxidants, including the master antioxidants, glutathione, are water soluable. 32:38 They do beautiful work in the parts of the cell where water soluble antioxidants work, but that's not where CoQ10 works. 32:46 It works in fatty membranes where an enormous amount of oxidative damage actually happens, including the membrane of your mitochondria and the surface 32:57 of you LDL particles. 32:58 At least I believe we know. 33:00 Your doctor's going to disagree with me here. 33:02 But the evidence agrees with that cholesterol on its own is not the enemy. 33:07 There are so many other things, but we do know that oxidized cholesterol known as VLDL is much more problematic than just LDL itself. 33:19 And CoQ10, the thing that statins prevent your body from making enough of is the primary defender of the LDL that you have keeping it from oxidizing and 33:31 actually causing real problems. 33:33 Do you see why statins just don't hold up and make as much sense as everybody tries to convince us that they do? 33:41 The other thing, and it's an important one, is that CoQ10 is an incredible teammate, not just with PQQ, but with vitamin E. 33:48 Vitamin E neutralizes a free radical and then it gets used up in that process. 33:53 and it has to be regenerated if it's going to go back to work. 33:56 And CoQ10 is one of the things that actually hands it back its charge and says, go do it again, vitamin E. 34:04 So Coq10 doesn't just fight on its own, it actually keeps teammates in the game longer. 34:09 And the fourth thing about CoQ10 that I think is so awesome is that it's the antioxidant that your body makes itself. 34:16 It makes less of as you age and that this common medication that, I hope, becomes less common, the more people find shows like mine, 34:24 statins drain from the body. 34:26 That combination, you make it, it central to energy, protects the fatty parts of your cells, recharges other antioxidants, 34:32 and it is declining right when you need it most. 34:35 is what earns it a place as an extraordinary antioxidant. 34:40 So I talked about the Multi and I won't belabor it too much. 34:42 I have an entire show where I talk about all the updates and upgrades to the multi, I'll link to that in the show description. 34:47 But basically I decided based on everything you just heard that CoQ10 and PQQ deserve a spot in The Ultimate Vitality Multi. 34:55 It's important to understand, too, that I would have put CoQ10 in the Multi years ago, but Coq10 was so much more expensive years. 35:04 It would've driven the price of the multi through the roof and it has come down in price. 35:08 Thankfully, competition has increased. 35:11 Kenneka is the kind of gold standard Co Q10 company, But they're not the only ones making a good natural one now. 35:16 And that's when the. 35:17 Price came down. 35:19 which is amazing. 35:20 So we finally had competition and the price dropped, supply and demand, all those things. 35:26 And CoQ10 became something I could throw into the multivitamin without increasing the prices, which was such a big factor for me because I still wanted 35:35 the multi to be this incredible value. 35:37 And I didn't put a massive quantity in. 35:39 A, I don't have a lot of space. 35:41 And B, it's still kind of an expensive ingredient. 35:44 But I did put what I thought for everybody is at least a baseline dose that would be useful. 35:49 That's the 30 milligrams, which is the first dose of CoQ10 that ever made it to the marketplace way back when. 35:55 Because there were good clinical studies showing that amount was helpful. 35:59 I put much higher dose as a percentage. 36:02 of PQQ, 50% of what the best studies show PqQ does. 36:06 And I did that A, because again, P Q Q is much more expensive than CoQ10. 36:10 So we're still keeping the price in check, but I felt P q q at 10 milligrams is fantastic across the board for everybody supportive of more mitochondria, 36:21 which we all want. 36:23 and I would say most of us probably feel like we need from an energy standpoint, but also it allows you to take half as much PQQ, 36:30 just 10 milligrams a day to get that optimal dose of 20 milligrams, which saves you money on the bottom line. 36:36 That's why they're in there. 36:38 And I hope that that all makes sense to you. 36:42 So Jackie, again, thank you for bringing this topic up. 36:46 I don't know why I didn't think do one right after I did the multi, but I all kinds of things filtering through my head all the time on what I'm going 36:52 to talk about on this show. 36:53 But again, if you are listening, whether you're someone who's already suggested a topic or there's a topics that you'd really like to hear about, 37:01 I'm all ears. 37:02 I would love to deliver a show that YOU want to here. 37:05 Reach out to me. 37:06 Either you can make mention on Spotify, you do it on YouTube, or you could do on our website, VitalityNutrition.com. 37:11 You can come into Vitaly Nutrition and tell us yourself or give us a call on the phone. 37:16 801-292-6662 I hope this episode was useful for you, and especially if it would be beneficial for somebody you know and care about, 37:24 please send it, share it. 37:26 Like it subscribe. 37:28 Give me a five star review. 37:29 Any of the things that helped this show grow. 37:31 I would greatly appreciate it until next time. 37:51 Hello, everyone. 37:52 I hope you enjoyed this week's episode of Vitality Radio. 37:56 Just a reminder that this podcast is for educational purposes only. 38:01 This podcast has not been evaluated by the FDA. 38:21 Thank you.
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