Deepen Your Knowledge: Alpha Synuclein Part 2

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Summary
  • Deepen your understanding of Alpha Synuclein’s role in neurobiology
  • Explore advanced research findings related to this protein
  • Learn about potential therapeutic approaches targeting Alpha Synuclein
  • This video is part of The Parkinson’s Solutions Summit
Transcript
Kenneth Sharlin, MD

I’m Dr. Ken Sharlin. I’m gonna talk a little bit about alpha-synuclein and whether or not it has a normal role to play in the brain, or in the body and the answer is yes, although its exact function is not fully understood. In its normal state, alpha-synuclein is a soluble protein that’s abundant in the brain, particularly in the presynaptic terminals where the nerve cells hold things like dopamine, and it’s involved in the release and regulation of neurotransmitters. The proposed normal functions of alpha-synuclein include number one, the regulation of neurotransmitter release. Alpha-synuclein is thought to be involved in the regulation of neurotransmitter release, particularly dopamine. It may play a role in maintaining proper synaptic vesicle function and neurotransmitter release, which are essential for normal brain function. Number two synaptic plasticity. Alpha-synuclein has been implicated in modulating synaptic plasticity, which refers to the ability of synapses or the connections between nerve cells to change their strength and connections in response to nerve cell activity. This process is crucial for learning memory and normal brain functioning.

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