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Joel Kahn, MD, FACC of Detroit, Michigan, is a practicing cardiologist, and a Clinical Professor of Medicine at Wayne State University School of Medicine. He graduated Summa Cum Laude from the University of Michigan Medical School. Known as “America’s Healthy Heart Doc”. Dr. Kahn has triple board certification in Internal... Read More
Barrie Tan, PhD is hailed as a trailblazer and the world’s foremost expert on vitamin E. A scientist first, Dr. Tan earned his PhD in Chemistry/Biochemistry from the University of Otago, NZ in 1978 and spent several years as a professor at UMass. Dr. Tan has committed himself to the... Read More
- Learn how statin medications lower LDL-cholesterol to reduce heart disease risk and impact the production of essential compounds in the body
- Understand the lesser-known effects of statins and why this matters for overall health
- Discover how GG-Pure, a vitamin from the Amazon, helps restore balance by replenishing the beneficial compounds reduced by statins
- This video is part of the Reversing Heart Disease Naturally Summit 2.0
Joel Kahn, MD, FACC
Alright, everybody. You got to sit down. Buckle up and get out a pad of paper or a notepad. If you were at the Reversing Heart Disease Naturally Summit, you saw one of the most energetic presentations from this wonderful gentleman, who is a year smarter. He’s not a year older. He’s a year smarter this year. Dr. Barry Tan, T-A-N, PhD. He hardly needs an introduction.
He’s a world-famous researcher, scientist, and businessman. He is the founder and chief scientist at American River Nutrition in Massachusetts. We just had the opportunity to be together at a world-famous longevity and anti-aging conference. Everybody wants to be around. Dr. Tan. It is like Ringo Starr and Paul McCartney of nutrition, anti-aging, and science, and that’s true. I got a chance to say hello, but I had to push people left and right.
He’s made major contributions in the field of vitamin E. Maybe you’ve heard of tocotrienol and an incredible plant from the Amazon called the Annatto Plant—this gorgeous red, flowery plant. But now he is an expert on how to handle some of the good and bad of statin medication. Statins, lipitor, and restore. I spend every day talking to patients, and the number one conversation we have is with the doctor, why am I having trouble with my statins my brother had a statin, and everybody seems to have a story about these drugs, even though in conventional cardiology they are still widely used, and I use them too. Dr. Tan, thank you for being here.
Barrie Tan, PhD
Thank you. Thank you for the kind introduction. We are looking forward to maximizing this wonderful time we have together.
Joel Kahn, MD, FACC
Well, thank you. Tell us a little bit. Let’s focus on this conversation. Everybody listening knows that heart disease remains the number one killer of men and women in the Western world. Everybody knows, I’m sure there are things called risk factors—smoking, diabetes, elevated blood pressure, but certainly elevated LDL cholesterol—that promote that chance your arteries get clogged up, and you, God forbid, have a stroke, a heart attack, a bypass, a stent, or don’t survive. Controlling these risk factors is the goal. If you can control your diet, exercise, stress management, or weight loss, that’s great.
But some people have genetic reasons. Their LDL cholesterol won’t go down, or they don’t respond completely to lifestyle. We have 40 years of data showing that lowering LDL cholesterol in a heart patient is one measure to lower their risk of heart disease. Tell us, in the liver, how do we make cholesterol, which is where most cholesterol is made, and how do statins work? You can be brief. Most people have a clue about this.
Barrie Tan, PhD
Yes. I think the easiest way I can do this is for everybody in the United States. All of us here know about Interstate 95. Easier to fly to Florida. One in every three Americans traverses that highway. that in the human body is a pathway called the mevalonate pathway. This is a pathway to making cholesterol, and without cholesterol, we cannot live; we just have to have cholesterol made. If you think of Maine to Florida and just think of it pictorially metaphorically, it worked. When they came up with this statin drug; it blocked it in Boston. They block it in Boston.
Just think of it. If you block it in Boston, then the traffic is going to be reduced. Then some way in Virginia, Washington, and D.C., that is the making of CoQ10 and CoQ10 drops. Everybody knows that when we take statin drugs, CoQ10 drops. Then some way in Atlanta, Georgia, muscle myopathy, a muscle problem happens. Where does cholesterol drop? The cholesterol drop is probably in New York. You’ve got a picture. Statin hits in Boston. Cholesterol drops in New York City, and in Washington, D.C., CoQ10 drops. then in Atlanta, a muscle problem happens.
Joel Kahn, MD, FACC
This is just everybody listening. It’s hard when we’re doing this just by conversation. We need to get out an old-fashioned folding map. I suggest Dr. Tan draw all this on a map of the idea that there are steps to create cholesterol. But from what you just said, I don’t think everybody knows the same pathway. I tell patients it’s a fork in the road; here’s cholesterol production. But here’s some other good stuff: CoQ10, and protein formulation. These are fancy words I’ve had to learn from you. We’re going to talk in a minute about testosterone production. You may want to block the fork in the road that leads to LDL cholesterol, but you don’t want to block the fork in the road that leads to CoQ10, and other good things. But when you take a statin like Lipitor, you block them both. Don’t you?
Barrie Tan, PhD
Yes. You block them both because statin is in Boston. If you hit statin in Boston, then in New York City, and then in Washington, D.C., and then in Atlanta, everything got blocked because you blocked it high. Where is cholesterol? Cholesterol sideways to New York City and then in Virginia, that’s where CoQ10 drops. People know about that, and then in Atlanta, muscle problems. Cardiologist knows about that, and they care for that patient. Somewhere, there would also be testosterone, and you’re going to ask me that.
But before this, no wonder people don’t know about this, that is why I’m trying to get you to notice that. When you leave New York City, before you get to Washington, D.C., the interstate passes through Philadelphia. Philadelphia, my friend. What is that thing in Philadelphia called? That is a compound called GG, Geranylgeraniol. That is it. If you hit it in Boston, cholesterol drops in New York City, and then we jump into Washington, D.C., and CoQ10 drops.
Now I’m here to tell you that Philadelphia thing, GG, it dropped. Now we have this GG, a small molecule once and forever to put it in because this GG in Philadelphia is responsible for the making of CoQ10. Because CoQ10 is down-streaming in Virginia, and then the muscle making, which is in Atlanta, is also dependent on GG. Therefore, I will produce a paper and study this scientifically. Why, if you add back GG in Philadelphia, it will fix the problem of CoQ10 in Virginia and fix the problem with a muscle in Atlanta. It will not go back upstream. You can only control it downstream. That’s how it works. I gave you a simplistic picture of this mevalonate pathway. It is very important in our body. That’s why I chose Interstate 95, the most traveled highway in the United States.
Joel Kahn, MD, FACC
Again, just because I’m learning with you, everybody is listening when you’re on I-75 highways making cholesterol in your liver. There’s a fork in the road. There’s a fork. We don’t hear much from doctors. That makes for good stuff. But when you take Lipitor, Crestor, Zocor, or Pravachol, you’re lowering your LDL cholesterol, and you’re robbing your body of good things. We’re calling that good pathway the GG pathway, but we’re blocking it now.
What did you discover? You have already been researching this plant from the Amazon called the Annatto, and you’ve learned how to create incredible, high-quality vitamin E products from the Annatto plant in the Amazon. But what did you discover that’s relevant to this production that was in those test tubes you were working with? What did you find there?
Barrie Tan, PhD
Before I leave, this is a picture of Annatto. It’s beautiful like that. We use our natural color for coloring cheese. This is a natural color. I removed the color and then discovered tocotrienol special Vitamin E. and then there is the special GG in it. When I studied this, what did I discover? When do I use GG? In the human body, GG is used to make two, three, or four things that I know well. One of them is GG is part of the building block of CoQ10. I cannot say it any simpler. It is just part of your building block. Since your audience can see this visually, I will segue, that here with my yellow pen, that’s the structure of GG. Then the background is the structure of the CoQ10. This is the molecule of CoQ10 in GG. If you look at the black-and-white molecule here, it is about two and a half times the length of GG, which is that of CoQ10. GG is the building block of CoQ10.
Why did people not hear about it before? Because my company, American River Nutrition, is first in class, We are the first company in the whole world to make these compounds from these Annatto plants that you saw. That is, it says one. The other thing that we found we can do is remember, that GG is in Philadelphia. It makes CoQ10 in Virginia, and then it also makes in Atlanta, the skeletal muscle protein. If you zap statin in Boston, everything goes down.
The reason CoQ10 goes down is because it zaps GG in Philadelphia. Therefore, there isn’t enough GG to make CoQ10. It is that simple. if you zap GG, it is not available to make skeletal muscle protein. That’s why doctors care for patients because they have statin-associated muscle symptoms. Now the audience can Google SAMS, Statin-Associated Muscle Symptom, you put SAMS you can read about it. The two things. The third one is also simple. Many of the audience know that you should take Menaquinone to make strong bones and strong muscles and menaquinone-4.
Joel Kahn, MD, FACC
Okay, that’s menaquinone-4. People have heard of vitamin K2. This is a version of vitamin K2.
Barrie Tan, PhD
K2 and the vitamin K2, the entire tail of vitamin K2 is GG. Therefore, if you zap the GG, the body is unable to make adequate MK-4 for vitamin K2. What does that mean? That means that the bone may begin to be more porous. That means that calcium is littered in the arteries, kidney stones, and gallstones. The balance of the calcium is not in the bone; it is in the soft tissues, and you don’t want so much calcium in the soft tissue. I gave you three or four good examples. If you leave GG by itself, it does those three or four things.
If you messed up the GG, then you are unable to make CoQ10 properly and unable to make MK-4 properly, unable to make skeletal muscle, probably. Now keep in mind that, as we age, we already don’t make enough GG, and what do you have? Because low GG means low energy and a low CoQ10 means low energy. We have less. MK-4, we have calcification of the artery. Then we have a loss of muscle mass, we call it sarcopenia. Those will have nothing to do with drugs. However, if we do with drugs, then we have a decimation of GG. If you decimate GG, then the worst thing can happen. SAMS can happen. CoQ10 dropped for the first time.
I’m telling the audience you already know if you take statin drugs, CoQ10 drops. I’m telling you the reason your CoQ10 drops when you take that drug is because that is so successful, not only in lowering cholesterol but also in lowering GG, and because you lower GG, that is the reason why CoQ10 drops. I explained to you why CoQ10 dropped and that’s because of GG. Until now GG is simply not available. I thought it would be a very powerful supplement to add CoQ10 and GG together. GG for the first time and the CoQ10, we use the most potent CoQ10, and that is Ubiquinol. Right now we’re doing a clinical study using ubiquinol, the best forms of CoQ10 and GG together.
Joel Kahn, MD, FACC
Again, everybody should write this down. Dr. Tan did not say that statins are evil, but he’s giving the most honest assessment that when you’re blocking the pathway that leads to making LDL cholesterol to help your arteries, you’re blocking this GG pathway. Now he’s talked about how that can rob your body of CoQ10, a very important antioxidant that gives you energy and may be one of the strongest longevity vitamins on the planet. I’m talking about actual scientific literature from Sweden and other studies. You’re blocking MK-4, which is a version of Vitamin K2, and you might want that Vitamin K2 for your bones in your muscles, but you’re blocking it if you take the statin blindly. You’re blocking potentially, protein and testosterone development.
Here comes the Annatto plant—that beautiful red plant. You can add back the GG, that you’re losing with age and you’re losing with your Lipitor, Crestor, and Statin. But you get the best of the world. You drop your cholesterol, but you add in the precursors, or you keep making those four big, helpful products.
Now, some people will say, How come my doctor didn’t tell me about this? How come I haven’t heard about this online you just shared it with me because you’re so up to date and I’m pretty up to date. You just published the paper a week ago, and when people are listening to this, it’ll be a couple of weeks ago. But it’s only recently that you tested on humans. What happens to testosterone levels? Both men and women need testosterone. When you add in this new vitamin you’ve created called GG, or the brand that Xtendlife makes called GG Pure. What happens to testosterone levels in human studies that you’ve just completed and published?
Barrie Tan, PhD
Thank you so much for asking this question when we did the interview. When we planned for this interview. This is not in the picture yet, but it’s just recently been published. It’s very simple. If you use Interstate 95, Remember, Atlanta is making muscle somewhere next to Virginia, where they make a CoQ10 that’s segue on that interstate; I think it’s 85 there. They come off a 95, which is the same way they make MK-4 and vitamin K2. Sorry, you’re asking about testosterone; the testosterone piece is after Atlanta. It is almost in Miami. Miami, remember, Interstate 95 is from Maine to Miami. I’m from Maine to the Florida Keys. In Miami, almost at the very end, testosterone is being made, and we get people this GG, then we found out that for men who are low in testosterone, GG increases by approximately 15 to 20%. To me, this is very dramatic.
I talk about that increase that is in the biochemistry textbook, but I have to sho clinical study. For the first time, we gave to healthy men and healthy women, particularly healthy men who have low testosterone, meaning that they are about 35 years old and older with testosterone, which is lower, can increase this testosterone. This pro-tends to increase the retention of muscle mass and the increase of energy and ability to thrive. The original finding in the animal study came from a Japanese scientist and was not originally from me. Initially, they used MK-4 and found out about MK-4 increases in testosterone in animals, and they said, Wait a minute, MK-4, the whole technology, why don’t we just test their GG and see if it would do the same?
They did that, and the GG also did MK-4 increasing the testes to increase the production of testosterone. We did this in a human study and found an increase. This is the study we published a few weeks ago. We’re going to put out a press release if the audience believes we don’t sell finished products. We do clinical studies based on this. If you come to American River Nutrition, we will post this, and you can download the whole paper and read it by yourself. What I’m telling you is that while we’re at this, we’re not even yet published. We already have the data, but it is not yet published. Would you go back to Virginia again where CoQ10 is made? Of course, I am curious and passionate about it. If you get people GG, will they increase their CoQ10 or not? We give them the GG, and you know what? The CoQ10 increased about a little bit above 20%, or 22%.
Ladies and gentlemen, this is as good as it’s ever going to get. Notice how I said I did not give these people CoQ10. I gave these people GG. We get them. We helped with this biohacking device. You give people GG, and you’re able to understand the biochemistry of the body. The body will use and employ the GG, correct the metabolism optimally, and allow the body to make CoQ10. This is as good as it is ever going to be. But I’m not saying that people now can take GG and don’t take CoQ10. I don’t know that yet. Therefore, we should have a product of GG and CoQ10. Together, you’re optimally allowing your body to metabolize, to have the best amount of CoQ10, as ubiquinol, and the best amount of GG because GG goes further than CoQ10. GG can protect the muscle. GG can protect the bone, and CoQ10 protects the muscle. Together, this is a truly good combo.
Joel Kahn, MD, FACC
People listening, this is how we try to bring high-quality people to interviews and high-quality content. But if you can, number one, there’s maybe you want to be on a GG product alone or a GG-Plus Ubiquinol product, which is called Xtend-Quinol, made by Xtendlife because you just want to optimize your GG pathway for all these wonderful products and you want to optimize your CoQ10 Level. We can’t make any claims that this is a longevity product that’s always nearly impossible to determine, but it might be because it’s going to support so many important processes.
But we’re talking about, I think, 40 million Americans on statins, and so few of them even take CoQ10 to protect themselves. But they certainly don’t take this combination of CoQ10, and GG called Xtend-Quinol. Or maybe you already have a bottle of CoQ10 you like. You just add in GG Pure, and you make your combination in GG Pure, which is also available from Xtendlife. But now you’re supporting and you’re telling us there’s new clinical data. I’ve always wondered about this. If I give a patient GG Pure, will they raise their CoQ10, blood level? 20% is a big raise. If I give a patient a GG Pure, will I raise their testosterone level, for which many men and women need a little boost? This is crazy good.
Barrie Tan, PhD
Yes.
Joel Kahn, MD, FACC
We’re talking about the way we should practice medicine. We have a theory. You had a theory. You come up with a product, then you do the scientific study, and you publish it. You don’t just say yes. Bravo, Dr. Tan.
Barrie Tan, PhD
Yes. Thank you. Before I go, if you order this from Xtendlife, I have sent them the paper so you can have Xtendlife send you the paper that I published. I’m not telling people who take Statins not to take CoQ10 and only GG because Statin is such a powerful drug. I don’t know if giving them GG alone can circumvent, but it will circumvent the muscle problem. But I don’t know for sure if it can circumvent the CoQ10 thing, and hence, there’s an option for people to take GG alone if they want to address the muscle problem or to protect the muscle as well as the blood level of CoQ10. There’s the option of this CoQ10 plus GG together, so I’d leave it.
However, if there are people who are taking Statins, I’m not advising them not to take the statins. If they are on Statins, then managing muscle problems, have them consider taking GG and the paper that I publish in a very well-known journal. Explain why they need to take it. By the way, to put where the research is, we’re doing yet another study, a clinical study in Texas, whereby we have people; listen to this carefully. We have people on Statin. They have heart problems under the care of a cardiologist who has confirmed myopathy. One group is a placebo. One group is then on a GG to see that if they’re on GG, they have confirmed myopathy. To see if the GG would reduce the muscle problem. If that study comes, it will most likely take another year to come out. I would be glad to tell you this, but given the fact that I’m willing to do this study, I’m willing to game it to find it. Does it do the job or not? If it doesn’t do the job, I want to quit the claim. If it does do the job, then I should let people know. I’m systematically done blow by blow out is clinical studies. Thank you, Dr. Kahn, for allowing me to have this half hour to chat with your listeners on this. This is wonderful.
Joel Kahn, MD, FACC
Exciting. Again, being an actual doctor who treats patients, I just finished a whole day of patients today, and the questions that all the time about Statins and complications, if you can’t tolerate a Lipitor or a Crestor, which might cost you $6 a month, the next choice is sometimes medications that are five $600 a month, and they’re hard to get approved by insurance.
When we’re talking about the potential in your study, you’re doing may show it. Add in a GG Pure, which is not five or $600 a month, or add in Xtend-Quinol, both products by Xtendlife from New Zealand, but they ship easily by DHL all across the United States so rapidly, and at a very reasonable price, you’re protecting your body and still getting the benefit from the Statin.
Neither you nor I are saying don’t take a statin. We’re just saying to take it in a way that is, the new paradigm. The problem is that if all the people listening go to their cardiologist or their internist, they’re not going to know this. We always say a new concept in medicine can take 17 years to become routine. Maybe in 2041, I think I did the math. It’s been 17 years now; hopefully, Dr. Tan and I will do another interview in 2041. Maybe by then, it’ll be routine. It’ll be called Lipitor-Quinole GG. It’ll just be routine. But it’s going to take a while to get everybody educated. I want to thank you because this is so exciting, and your upcoming research means we’re going to need to have you back next year for 3.0. But I think everybody learned a lot. Your map analogy is great, but just a fork in the road goes to cholesterol, and we like the Lipitor, block that. We just don’t block testosterone protein, MK-4, K2, and CoQ10, and by adding in GG there and Xtend-Quinol, which is GG Plus CoQ10, you get the best of both worlds.
Barrie Tan, PhD
Yes.
Joel Kahn, MD, FACC
Yes. I’ll just ask you; maybe this is too personal. Are you on a statin yourself?
Barrie Tan, PhD
I don’t mind. Full disclosure: I have genetic hypercholesterolemia, and the doctor put me on Statin, and from day one, I have been taking it. I do not have a muscle problem. I’m thankful that sometimes people are genetically disposed to duty. I have been taking 150 milligrams of GG. I also take about 300 milligrams of CoQ10, so it works just fine. I’m grateful. Nothing is a problem with me. They check my bloodwork. I don’t have any high muscle breakdowns. My CoQ10 is checked periodically. It’s quite on the high side, so I’m grateful. It’s good. No problem with any muscle problems,
Joel Kahn, MD, FACC
After you do this human Statin muscle aching study you mentioned, which we all want to hear about when it’s done, maybe we can do some research looking at the potential that GG and CoQ10 have some anti-aging effects. Whether it be on epigenetic age, telomeres, or some other measure, I think it’s very possible that this could have profound implications. But we have to test it.
Barrie Tan, PhD
Yes, we have to do it. Another time when we talk, you can ask me because you are very interested in anti-aging. I know that GG in animal studies and tocotrienols in animal studies have anti-aging implications because they work in so many functions in our body. Overall, the function is to reduce inflammation and the longevity of the animal. Both increase the length of their lives as well as the quality of their lives. That’s what I call anti-aging—both the length and the quality of daily life.
Well, thank you so much for having me on. I hope that your audience is well blessed. If I ever run into the listener when I’m doing a book signing or talking about that, come up and say, Hi, I would love to meet you in person sometime. I go to different trade shows periodically, and I can do that, so bless you and have a wonderful new year, and be all good and healthy.
Joel Kahn, MD, FACC
Thank you for all the contributions you have made. They’re going to help so many people. Thank you so much. Have a good evening.
Barrie Tan, PhD
Thank you.
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If you are not in statins will these be helpful?
If someone is taking a statin ,theid blocks both the good and bad cholesterol , is that what you were saying at the beginning of this interview