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- Autism has a strong inflammatory and immune component. Dr. Nikogosian describes severe autism as genetic susceptibility combined with environmental triggers. Together these drive chronic neuroinflammation and immune dysfunction that disrupt brain development and destabilize neural networks.
- Exosomes may work through microRNA “signatures,” not single targets. Exosomes are tiny vesicles secreted by mesenchymal stem cells. Their microRNA cargo fine-tunes gene expression across entire pathways, which may suit a complex, polygenic condition like autism.
- Early observations are encouraging, but the questions are still open. All 20 patients in his case series reported some improvement, most consistently in motor planning and autonomic regulation. He has seen no serious adverse events across 88 treatments. But this is an uncontrolled case series, there are no human trials of exosomes in autism, and the ideal treatment interval is still unknown.
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