Full Transcript Introduction and reunion 0:08 Hi. Welcome to the Peptide Summit. 0:09 My name is Starker Matt Cook, and today 0:12 I'm very delighted to introduce you to, Doctor Kent Halter. 0:17 He was the host of the Peptide Summit last year, and, said this can be 0:22 piece of cake. Is going to take hardly no time. 0:24 You're gonna you're going to have a great time doing it. 0:27 And, and, it actually has been kind of 0:30 a highlight of our year, although it has done, big responsibility. 0:34 I, met Doctor Halter probably more than 12 years ago. 0:39 We were at, 0:42 at the coldest I. 0:43 Lads, meeting in the history of AI labs, 0:47 up and up in Banff, Canada. 0:50 And I actually remember how freezing cold it was. 0:53 And I think you you may even remember more how freezing cold that was. 0:58 I have a two degree temperature tolerance. 1:01 I'm like, this is unlivable. 1:03 People can't live here. 1:04 I went to get put gas in the car and, like, you can't breathe. And. 1:09 But I think some guy walked by and shorts. 1:12 Yeah, yeah. 1:13 It's like this is unlivable. 1:15 I think it was just, you know, I couldn't 1:17 believe it, but, Yeah, it's, Interesting. 1:21 Time flies, man. 1:22 I mean, I, I, I did lie to you and tell you as it's 1:26 a piece of cake that was. 1:29 But but, 1:31 in terms of medical, stuff, you've always told me the truth. 1:34 That I've actually loved. 1:36 My relationship with you was interesting. 1:37 We met, and, you were well, on your way of being a luminary 1:42 in taking care of patients with complex illness. 1:45 And, we sat together for that 1:48 meeting, and I would say, really? 1:51 I've been having conversations with you, 1:57 here and there over the 1:58 last decade, and I always look forward to them. 2:02 I always look forward to what I learn from them. 2:05 And then when, 2:07 when you speak about things and, we'll talk about a handful of these today, 2:12 I'll all here I was, you know, at the peptide some or peptide. 2:18 Symposium today for forum last year. 2:20 And I was like you were saying things and I just kept going, 2:23 oh, yeah, that's what I do. Oh, yeah, that's what I do. 2:25 Oh that's right, that's that is true. 2:27 And, and so I, I believe that 2:30 in terms 2:31 of thinking about complex illness, I think you're one of the most thoughtful 2:36 and wise and, imaginative, imaginative and incredible doctors in the world. 2:43 And so I'm super grateful that you exist and that, you're 2:47 continuing to work in this field and, you're an influence for me. 2:51 So, thanks for being here. 2:53 And thanks for taking the time of the. 2:55 Thank you so much. It's so nice of you, but, yeah, it goes both ways. 2:58 And it's interesting how when you kind of feel a certain way and go, 3:02 wait a minute, this isn't right. 3:03 Or kind of the standard, even like the integrative doctors are thinking 3:07 one way, like, wait a minute, that isn't right. 3:09 And then you and I end up saying, you know what? 3:13 That we both think that isn't right and this is the way it is. 3:17 So it's very cool to get that confirmatory, 3:20 you know, person like, hey, what do you think of this? 3:22 Like, wow, you thought the same thing where everyone else thinks this. 3:27 So, yeah, it it just, 3:30 I just love my, you know, relationship with you as well 3:33 and love, you know, throwing ideas back and forth and going, 3:37 yeah, I agree, you know, like, well, I thought that I'm 3:41 the only one thinking this, you know, and 3:44 I think so today we're, 3:47 we're going to talk about, sirs, 3:51 which is basically I'm going to let you define it and we'll kind of get into that. 3:56 We're going to talk about taking care of complex immune problems. 4:00 And, and I think, you know, I cried a 4:05 with a lot of gratitude, the opportunity that I, 4:08 we get to take care of these patients because I think in taking care 4:13 of these problems, it's helped us as we began to think about 4:18 the trajectory of where we're going over the next 4 or 5 years in terms of complex 4:22 immune problems, which is going to be thinking about things like Covid 4:25 long Covid and and, and the overlap 4:30 of everything from vector borne infections to water damaged buildings 4:35 to, to sort of the viral infections. 4:39 And then how the cancellation of all of those things impacts on our 4:43 biology and impacts both how we feel and then how our immune system works. 4:49 Yeah, I I've really found it's amazing is that 4:53 it's all the same underlying pathophysiology, 4:58 which goes along with aging. 5:00 Like, why does all this stuff happen?
SIRS and complex immune illness 5:02 You know, people that are unhealthy older, 5:05 and it just all fits and it kind of simplifies it. 5:10 And peptides are like the perfect thing to fix this, you know, immuno senescence, 5:16 T-cell exhaustion and everything is a vicious cycle in medicine. 5:20 And you find that all these illnesses are just different 5:24 parts of the same physiology. 5:27 Okay, perfect. 5:29 So then 5:31 given that, 5:33 let's start with more associated problems and sirs, 5:37 and tell us about that kind of at a high level that I think is going 5:41 to introduce us to sort of some biology, and then we'll kind of start to get into 5:46 some of the ways that we think about treating people and some of the ways that, 5:50 that expresses itself. 5:53 Yeah. 5:53 When I was, you know, seeing serious patients and, you know, 5:57 learning about Sears and Shoemaker and all his research and, 6:02 there were just a couple issues I had, like, is this really different? 6:08 You know, the chronic inflammatory response syndrome, 6:12 which whether you want to call it the cell danger 6:15 response or, you know, I want to have this new part 6:19 and I think it's really part of this elephant, 6:21 you know, everyone feels a different part of it. 6:23 And, and they all fit there. 6:26 All right. 6:27 But it's just the, these different parts. 6:29 And with the series, you try to put together, a whole thing. 6:34 And when you see these patients especially, 6:37 they've had underlying immune dysfunction before. 6:42 They've had, you know, diagnosed with mold toxicity. 6:44 Mold toxicity is a real thing. 6:46 It's very kind of, you know, the, the new thing. 6:50 But everything is multifactorial, right? 6:53 It's, you know, immune system, aging, inflammation, 6:58 stress, MRI from the environmental things. 7:02 I mean, they all add together, like, 7:04 I haven't seen a Sears patient that, you know, is mold toxic? 7:08 That doesn't have something else going on. 7:11 And and that's the thing. 7:12 So you get people in the same house 7:14 where everyone else is fine, but there's one person. 7:17 Well, what's 7:18 what's the difference, you know, and you really look at the immune system. 7:22 And we found that that is the core start of everything. 7:26 Yeah. 7:26 And so when, when you look at it as you age. 7:29 So there's basically two sides. 7:31 I mean there's a 7:32 and this is an oversimplification in anything with the immune system 7:35 is oversimplification because you have to because it's so complex. 7:39 But you look at the stuff inside the cell takes you to step outside the cell. 7:44 There's 17, 7:45 which, you know, causes more autoimmunity, which I thought was one before. 7:48 But so as you get older, any stress, any, 7:52 environmental toxins, 7:55 any emfs, whatever the one goes 7:58 down, THC goes up, and then you get reactivating infections. 8:02 You get you can't, basically detoxify mold. 8:07 And then you get, let's say, like an infection. 8:10 You're much more prone to it. 8:13 Let's say you get Covid, when you're prone 8:15 to long Covid, you get to reactivate infections. 8:18 You get, mitochondrial dysfunction, which then causes, pineal hypothalamic 8:24 pituitary hormone deficiencies across the board. 8:28 You get immune activation of coagulation, you get mitochondrial dysfunction, 8:32 you get, you know, basically everything's a vicious cycle and feeds on each other. 8:37 And then that suppressed immune system more you get more reactivated infections, 8:41 and it just goes around and around. 8:43 So it becomes the chicken or the egg. 8:45 Okay. What is the problem? 8:46 Is that the infection? Is it the mold? 8:48 Is it the, immune system? 8:51 Is it the mitochondria? 8:53 Is it the, pineal hypothalamic pituitary hormone dysfunction? 8:57 So it's all these. 8:59 Yeah. You can point to all these. These are dysfunctional. 9:01 This is what causes it. 9:04 But it's everything. 9:06 So you really have to treat multiple things. 9:11 But we're really finding is that the underlying key. 9:15 Basically pathophysiology is the immune system. 9:20 You fix that and it's like, you know, and you got mast cells. 9:24 You've got, you know, and you look at the natural killer cells, 9:28 they're just, you know, nonfunctional, it's with aging and immuno senescence 9:33 and with, like, any toxin or infection, 9:37 if it goes along for a prolonged period, 9:41 then the the T cells shut down. 9:44 So you get to it's called T cell exhaustion. 9:47 A lot of, money and research being put into this 9:51 and also immuno senescence, and your immune cell doesn't work. 9:56 And that is the whole key to everything. 9:59 Because you can't suppress the infection. 10:01 You can't suppress, 10:03 you can't get rid of the toxins, and you fix the immune system. 10:07 You're well on your way to getting better. 10:09 But if you don't, you're not going to get better. 10:11 You're going to be maybe feeling better here or there at fix. 10:14 This fixes to this. 10:16 But if you don't fix the immune system or if you kill everything, 10:19 get rid of every toxin. 10:21 Yeah, the immune system can come back. 10:23 But that's pretty inefficient way to try and do it. 10:27 You know? 10:28 And it's a little bit like my own self. 10:30 And that's where I think I really realize is 10:32 that, you know, I basically since birth, Lyme, Bubka, 10:36 Bartonella and did three and a half years, the highest dose, antibiotics. 10:40 You've heard the story before and I didn't touch anything. 10:45 Nothing was done by natural killer. 10:47 Cell function was zero, you know, and I was in the hospital. 10:50 There were times where for sepsis and the nurses would say, oh, this. 10:54 The Aids patient keeps turning negative for HIV. 10:58 And until I fixed my immune system, nothing worked. 11:04 So 100% good one. 11:07 So then, 11:10 what do you like to do to test the immune system? 11:14 And then we'll sort of get into. Then what? 11:17 How do we fix it? 11:19 That's a good question. 11:20 And, you know, I think and the problem is we don't have great tests and the tests 11:26 are a pain in the ass. 11:27 It just happens to be like, if you go to quest or LabCorp, 11:31 that natural killer cells function, 11:34 I think is the, biggest key. 11:37 But they screwed up 11:40 80% of the time. 11:42 You can do natural killer cell number, but it's the number. 11:46 Like, let's look at, like, the studies on chronic fatigue syndrome. 11:49 About 25% of chronic fatigue syndrome patients have low natural killer 11:52 cell number, about 75% of low natural killer cells function. 11:56 And that's looking at their standard reference ranges. 12:00 And I've talked to so with natural social function like quest 12:05 which they send out to national Jewish or I will see for a but another one. 12:11 But I called the medical director 12:14 there and just said your reference ranges are ridiculous based on the literature. 12:17 And he says, I know, but that's, you know, they each lab has defined their own 12:22 reference ranges, so they're like less like normal is greater than eight. 12:28 No, it's really greater than 30 is what the, the studies show. 12:32 But they have to do their own little reference ranges. 12:34 So because a problem when doctors, even if they do those tests it looks normal. 12:40 It's say they're ten. 12:42 It looks normal. No. 12:43 But it's, it's very, very low. 12:45 So there's problem with, 12:47 you'll get in the labs at Sephora even those, they screw that up. 12:51 Even showing growth factor beta. 12:55 Which you look for for H2. 12:56 So improve growth factor beta and see for a probably the best markers 13:01 to for one, is probably the downstream is natural killer cells function. 13:07 The cytokines can really lead you astray 13:10 because they are very difficult to do. 13:14 And also it's if one side, let's say is is low, 13:20 it will try to raise itself or suppress the other side, 13:23 and it will actually think the other, the will send you the wrong direction. 13:28 So it's not what the body's trying to do, it's what the body's doing. 13:32 Right. 13:33 So the cytokine tests tend to be, 13:36 but usually where at least they'll come out zero or, you know, all over the place. 13:41 But, so we'll look at those downstream numbers of what's really happening 13:45 with, with the body. 13:47 But in, in syrinx, has some, good tests that we're using more. 13:51 I've just started using them, but they look very promising. 13:55 Which ones are those? 13:57 It's. There are T-cell immunity test. 14:01 Are you just speaking of the T-cell? 14:04 Have you been using the in fact. 14:05 Oh. Lab T-cell immunity in terms of, for, for Lyme testing. 14:10 No. And I keep meaning to 14:13 because I've heard great things about it, but, no. 14:16 And I, they came to our office and, it sounds very good. 14:20 And I just kind of keep getting to that one. 14:24 I like to do from from the perspective of. 14:30 If I'm so if, 14:32 if we're thinking about like, immune problems that can affect people, then, 14:37 one thing could be water damaged buildings and then that, 14:41 that's mold, but that's potentially mold plus that kind of mix. 14:44 And people have been kind of hearing this potentially gram negative rods 14:48 if it's on the, the tickborne side, 14:51 then that could be and you know, this as well as me, 14:56 but it could be Borrelia, could be Bartonella, could be babies. 15:00 Yeah. Those are like the Holy Trinity. 15:03 And, and and then all of these other, 15:06 vector borne infections plus or minus Epstein-Barr and stuff like that. 15:12 You can 15:13 look at I genex well, look at the antibodies 15:17 to, to those, the in fact, I will lab 15:20 will look at the T-cell response to each one of those. 15:23 And so then if I, I'm really trying 15:24 to weigh in on that, then what I'll do is I'll look and I'll see. 15:29 Okay. 15:29 How are your B-cells making antibodies. 15:31 How are your T cells responding. 15:33 And then sometimes I'll see people that don't make any antibodies 15:37 that that would be a thought to be negative for Lyme. 15:41 But then I'll do the T-cell test. 15:43 And it's super positive. 15:45 And so and that has that's been an interesting piece. 15:50 And then that also can 15:53 are those the sicker patients that you see sometimes sometimes. 15:57 And so then that's an interesting sort of piece. 16:01 And the the, the, the fact that I brought up the mold 16:06 piece with it as is because there's so much overlap, I think a lot of the, 16:11 the people who really struggle on the vector borne side actually have mold 16:16 or are somewhere on the spectrum of chronic inflammatory response syndrome. 16:22 And then and, and then I agree with you is because it's the whole thing. 16:27 And then other other other stimuli that come in, whether that be the gut 16:31 or whether that be the Covid or whether that be other inflammatory, 16:36 other things that drive inflammation or drive toxicity or heavy metals. 16:41 But then were. 16:45 I think getting a better and better map and model 16:48 of what's actually happening now, because this kind of like, okay, 16:52 we can kind of delineate to the extent of the infections, 16:55 the extent of the toxins, the extent of and then begin to think about it. 17:01 But then, one topic 17:03 that we decided to talk about today was, binders 17:07 because in, in the, in the arc of these infections, 17:12 and toxins 17:15 one probably the, the most common treatment
Testing immune dysfunction 17:19 that people have used to for mycotoxins has been 17:23 to take a lot of different binders to bind those toxins out. 17:27 But you've got a little bit of a contrarian perspective on this. 17:29 So tell me about I hate binders, but no. 17:34 Yeah. 17:34 People are going to scream, but, the just, mentioned about the, 17:39 abusive with the with, you know, the positive, T-cell negative antibodies. 17:44 If you have low pH one, you can't convert 17:48 or you actually can't convert Idem, which is basically noncompliant. 17:53 Antibody is against a, infection or whatever it may be. 17:57 It just kind of holds on to it to IgG, which is, 18:00 complement, activating and kind of blows up the thing. 18:05 And also you just don't make antibodies in general with low t H1. 18:11 So it also goes to those are the patient low to H1. 18:15 They don't have any antibodies, you know. 18:17 And and those are the sickest patients. 18:20 It's funny. 18:20 It's like, you know, you look at a, Western blot and, you know, blot, 18:25 and six patients have no bands, you know, it's like, 18:29 yeah, you got and you got no bands, you know, and I, I've learned to. 18:33 It's like when I say, you know, chronic Lyme disease, I just 18:37 mean we don't even know what we're treating an infection. 18:40 You know, 18:41 it's just there's so many that we don't, we can't even test for there, you know, 18:45 hundreds and thousands of these things, and different strains and, and all this. 18:49 So and myself, you know, all I had was to start 18:53 with when I got very, very sick and Bedbound was 41. 18:57 Kill it all. Been on the exam. 18:59 And, and then when I treated my immune system, 19:03 I had eight bands and IgG after that, you know, so it it shows that, 19:08 you know, people with no immune system, you can't go by the immune response. 19:12 But yeah, with by our hold on a second before we go 19:16 in on that. 19:19 That's a crucial 19:21 I want you to talk a little bit more about that, 19:23 because that's a crucial fact for people to hear about when you start 19:27 to think about these problems. 19:28 Because I will often, 19:32 you know, get somebody that comes here and says, you know, I went to Stanford, 19:36 and I saw the ID there, and they said, I definitely don't have Lyme disease 19:41 because they did one test and then they didn't have any, 19:45 any bands or, and, and they had negative antibodies. 19:50 But then many times when you start to bring the immune system back, 19:56 all of a sudden those will appear in, in that first six months of treatment. 20:02 Yeah. 20:03 And, and that's, that's what we find. 20:04 And even with, 20:06 you know, Lyme disease we find if someone has Lyme disease 20:08 they probably have multiple other infections as well. 20:11 Right. 20:12 And or just so focused on one thing, which is why all these studies on, 20:18 you know, chronic Lyme disease is so controversial 20:21 because giving high dose antibiotics for a year or two, 20:26 well, it can help, but maybe it doesn't because 20:29 there's so much other stuff going on. 20:31 And, and I think we have so many infections. 20:34 And when you look at that, I really I don't even know if you even get rid of 20:39 I could treat myself or anyone else, you know, for chronic Lyme disease, 20:42 you get rid of it. 20:43 I don't know, I think you just end up suppressing so many things. 20:48 But as your immune system drops, then all this stuff starts coming out. 20:52 Because if you check out a Lyme Lyme disease patient, they have Epstein-Barr 20:56 positive, you know, CMV, HSV sick, because immune system can suppress it. 21:02 So but these are things that everyone has. 21:05 And I think so many people have Lyme disease 21:08 that never have symptoms, right, is that they suppress it 21:12 and they're fine unless they get all of a sudden 21:16 they get in an accident, emotional stress, which is a killer, 21:21 which suppresses the immune system, especially one doesn't suppressing it. 21:24 Some like like steroids, people think it modulates that. 21:28 It lowers at TH1. 21:29 So emotional stress, divorce, death. 21:34 You know, spouse or family, 21:37 you know, some single stressful event, another infection. 21:42 A, you know, accident, 21:46 a, motor vehicle that whatever it may be sets it off. 21:49 And all of a sudden they're like, oh my God. 21:51 And then now you're looking for all these things, but it's the immune system 21:54 that's been suppressing this stuff now releases all these things. 21:58 And like, I just saw a patient of a day who had, like, you know, positive, 22:03 you know, Borelli, Bubka, 22:06 Bartonella, Epstein-Barr, and, I mean, what do you think? 22:10 That's what happened. 22:11 They got all these different infections, and then they got sick. 22:14 No, it's the immune system drop. 22:16 And now these things came back out. 22:18 So go to the heart of the problem. 22:21 Not trying to kill other people, put them on, you know, foul side 22:24 and Valtrex and antibiotics and all these things. 22:27 Well, no fixed immune system. 22:30 And those things take care of you may have to help it 22:33 in, you know, treat these other infections in different ways. 22:37 But we use very little antibiotics now. 22:39 And no longer do we do that. 22:42 You know, I was kind of the, Horowitz pro, which he's, he's he's amazing. 22:47 But, you know, just doing just massive doses of everything, killing it. 22:52 And it can it can work, but 22:55 it's much easier to fix the immune system. 22:58 And then maybe a month or two of antibiotics or antivirals. 23:03 And we're that. 23:04 Maybe we don't even need that. 23:06 Now, I, I agree, I, I 100% agree and and 23:12 and but then you know with with that in mind then I like to, you know, I had this 23:16 great, lecture a Hopkins 23:19 professor that was speaking about Lyme and he said 23:23 and speaking about neurological, I mean, and he was talking about neurologic, 23:27 neurological, Lyme. 23:28 And he said, you need a model 23:29 for neurological Lyme and it's drug resistant, neurological TB. 23:33 And so then their model is you need to get penetration 23:37 into the central nervous system of anybody products. 23:41 And they basically would do like a this for antibiotic cocktails 23:45 that are trying to basically get penetration in their. 23:50 And there's an aspect of it that I liked. 23:54 But then I said what are the antibiotics that we use? 23:58 And so then one would be like ozone, 24:01 one would be thymus and alpha one one would be L L 37. 24:06 Yeah. 24:06 And so then suddenly we've got you know, potentially 24:10 one is, is is to some extent vitamin D would be like a low level. 24:15 You know what I mean. 24:16 And so then 24:17 we're thinking about all of these things then would we add in something. 24:21 Occasionally yes. But for the most part we're 24:26 I, I have not been profoundly impressed 24:29 that big antibiotic cocktails will be helpful, 24:33 but I will have been impressed that antimicrobial strategies. 24:37 And then often we'll do 2 or 3 herbal and herbal antimicrobials. 24:41 And so then between peptides and herbals and managing the immune system 24:47 and sort of thinking comprehensively and 24:51 paying attention to stress. 24:52 Even I, you know, I was a nervous about it. 24:54 I echo what you said about emotional stuff.
Infections, mold, and immune suppression 24:58 And, you know, I had always been a little nervous 25:02 about doing still a ganglion block and a lot of the 25:05 the big sort of emotional recess that we do. 25:09 And now we do with everybody that has Lyme 25:11 and they are some of our really great responders. 25:15 And it's because they're so there's 25:18 there's been there's such an impact 25:21 of this physiology on the emotional system. 25:25 And a lot of times emotional stress, just like you said, triggered that. 25:29 And then resetting that I do find then begins to reset. 25:33 All of a sudden 25:35 starts to come back. 25:36 I think that that's a great, treatment. 25:39 And not a lot of doctors can do that, you know? 25:42 But it is. 25:43 And they get hard wired 25:44 that way, and they're just, you know, they're fight or flight constantly. 25:48 And, and it's so hard to get someone better. 25:51 I have a couple patients that are at home, and they're like, living at home 25:57 with their parents, and their parents are totally emotionally dysfunctional. 26:01 So they're just in this, like, constant, just terrible, toxic environment. 26:06 And they're not going to get better. 26:08 You know, it is like so difficult, if not impossible 26:12 to get them better because they're just constantly, you know, stress, right? 26:16 Yeah. 26:16 That's what they need 26:17 is like to ganglion block or something to relieve that stress. 26:22 Good. 26:25 Binders. 26:27 Tell me about binders. You know, 26:31 with binders. 26:32 I'm very A.D.D., which is why I also bought into this. 26:36 And I'm not saying is wrong, but this massive antibiotics 26:39 only get so much better. 26:40 I'm going to do more antibiotics than the next guy. 26:43 I'm just going to destroy this thing. Right. 26:45 And, and then I'm like, with binders 26:48 and you know, I had did all these different one of my 26:53 no one gets better like it's a cycle now people coming in. 26:56 I've been on this for years. I'm. 26:57 Yeah, I think I'm better. 26:58 And, I'm like, how long has it been? 27:01 You know, four years. 27:02 And I'm like, okay, you know, and I, I think it's binders can help it. 27:08 No, no doubt. 27:09 And there's people that are just plastic binders. 27:11 But is that it's kind of like the same thing with Marcel. 27:16 It's the people with Marcel are looking to directly influence a mass. 27:20 So they're just, you know, okay. 27:21 Antique, you know, and, you know, anti-inflammatories and, and, 27:26 and they, you know, Marcel stabilizers and, and stuff. 27:31 But look upstream, that's what we need to do. 27:34 And so the body is not releasing the toxins 27:38 because of low energy, low mitochondria functioning. 27:41 You look at, on heavy metals that people 27:45 with low mitochondrial function can't get rid of heavy metals. 27:48 And you see this classically with autistic kids, right. 27:52 And if you look at autistic kids blood 27:54 and a Lyme patient, they're almost exactly the same. 27:58 They have the same immune dysfunction, they have the same 28:00 mitochondrial dysfunction. 28:02 And they can't eat. 28:03 Neither of them can dump heavy metals. 28:06 It's the same thing with mold toxins 28:09 is that they can't get rid of them because there's no cellular energy. 28:12 So if you fix the cellular energy and which means mitochondrial function, 28:17 moderate immune system, you can get rid of these things. 28:21 And instead of just trying to take the little scraps 28:24 that are coming out for years, when the cellular 28:27 you need the detox cellular, not what's in the blood 28:31 is what's in the cells as well what's what's what's basically the toxin. 28:35 And so I just think it's it's like they it can help, 28:40 but it's just an inefficient way. 28:43 You're not fixing the problem. 28:44 You're just trying to kind of stay even with a, 28:49 I think of a bucket with water and a hole in it, you know, 28:52 and you're just, you know, trying to make that hole a little bigger 28:55 instead of fixing, turning off the spigot, you know, 28:58 one, 29:02 You know, I have 29:03 been, you know, there is this huge conversation 29:06 on binders, and I've been somewhat skeptical of binders myself. 29:10 What what I've personally evolved into doing is, is that I work out, 29:17 and then I take a sauna every morning, and then I do a cold plunge every morning. 29:23 And what I'll do is I'll intermittently 29:27 take some bitters 29:28 sometimes as kind of the push to kind of get your bile duct empty, 29:32 and then I'll take a little charcoal, but basically, 29:36 I'll take charcoal, a lot of charcoal 29:40 and mineral water and, lemon 29:45 and then that, and then I'll take a modified Citrus Pact. 29:48 And with that, because that actually has these, 29:51 some anti-inflammatory, effects 29:54 that and let's say it's a mild binder, but it's an anti-inflammatory. 29:58 And I'll take that with a little charcoal and with the idea 30:01 that I'm catching any detox from my liver that happened overnight. 30:06 And I'm kind of in a detox kind of sauna experience. 30:10 And so then I'll do that as my, like, one binder thing, 30:15 but then I'm done at that point for the day with binders. 30:19 And so I basically take like two modified foods, citrus pectin and some charcoal. 30:23 And then that's it. 30:25 And as and, and I'll, I have to say 30:28 I'll feel better or I feel great when I do that. 30:32 But that's like a real light binding 30:36 group. 30:36 I mean, I, I really think, you know, we're going to see so many people 30:39 sick and I think you're already seeing it. 30:42 And we're just being bombarded with so many toxins 30:46 and emfs and pollution and, you know, heavy metals. 30:50 And it's like, you know, you go get sushi, like, I'll take I'll take some binders 30:56 when I eat sushi or something, you know, 30:59 but, it's just, we're, 31:02 we're, we're just being bombarded with so many toxins. 31:06 And I think you see that it's like I, you know, I carry lab slips in my pocket. 31:10 I go to a party because everything comes up and goes, 31:13 oh, my God, I'm so sick or my daughter's sick 31:16 or my friend's sick or whoever, someone is really sick. 31:21 Like in every family, it seems like now. 31:25 And we didn't have that 20 years ago, you know, 31:29 and all these, you know, conditions like, like Sears, we didn't, you know, 31:34 you never heard of that. 31:35 And molds been around forever, right? 31:38 And so then now if you're like, you and me 31:42 walking around in our lives, that's exactly right. 31:47 And that's kind of how I got into this, because basically, I would be taking care 31:51 of, like, families. 31:51 And then next thing you know, there's like somebody in every family with. 31:55 Yeah, one of these problems. 31:56 And so then it just became something that I had to figure out. 32:01 Like, Barb sent me up to Canada where I met you because we were trying 32:05 to figure out Lyme disease like 12 years ago, you know what I mean? 32:09 And so then that that happened 32:13 and at that time and then from that moment 32:17 until, like the last few years, 32:20 if I had $100 for every person that I heard 32:24 was on a protocol where they were taking binders, 32:28 and then they were hoping that they were going to take binders for a long time. 32:32 And that that was somehow going to bind out all of the mycotoxins in their body. 32:37 And then at some point, 32:38 they would be ready to take this magical peptide called VIP. 32:42 That was going to miraculously sort of solve everything. 32:47 Yeah. 32:49 You know, I would that would be, 32:52 you know, a lot and then the 32:55 and then you would say, well, are there 32:59 there must be thousands of people that you heard about that did that protocol. 33:04 And then that protocol was really, really amazing. 33:07 And then I would be like, I almost don't know anybody that did that. 33:11 And then that worked. 33:13 And I think that that and I'm guessing that that probably is a similar experience 33:17 that you had, which has led us both to try to kind of try to go 33:22 upstream and say, is there something else that might 33:25 help people feel better, which would be optimizing the immune system? 33:28 But tell me your perspective on that one. 33:31 No, I, I totally agree, same same experience 33:34 and I just started, you know, because I really respect 33:37 the shoemaker and all the research he's done and but I'm like, 33:40 does it make sense when I look at the what VIP does and it lowers 33:48 one, it lowers natural killer cell function raises to two. 33:53 And I'm like, I don't understand why this you know, 33:57 I understand why he says, don't give it with information to make it worse. 34:01 But if you get rid of everything, it's kind of like a, a steroid shot 34:07 where they're going to feel better, right, for a period of time. 34:10 But you're not helping them. 34:13 It's actually you're making them worse. So. 34:16 So VIP actually will suppress everything 34:21 and but do more of a suppress one tissue so people go, oh, I feel better. 34:26 But then they're never healed. 34:29 They're never over it. 34:30 And if they get it a moldy thing again, they're just really, 34:34 very likely to just, respond. 34:37 And, and so that's why it did make sense to me. 34:40 And so, you know, looking at, 34:44 looking at the studies that it. 34:47 Yeah, it can help people in the short run. 34:50 But you're making them worse in the long run. 34:54 And it also which I found out that it 34:58 dramatically increase your risk of many, many cancers. 35:02 Basically prostate 35:05 cancer, alley colon cancer. 35:08 And it makes sense because it's suppressing the natural killer 35:11 cell function, you know, and so it's something that 35:16 it doesn't make sense to me to use. 35:19 And it didn't. 35:20 And then but I had some some people say they felt better, but it's interesting. 35:25 So another doctor, came up to me 35:28 and said, you know, then she treats Lyme, she had Lyme. 35:31 And, all this, and she was feeling much better. 35:34 But then she did some sprays of VIP for a number of days, and all of a sudden 35:40 she just crashed and she has not been and she's had it's 35:44 been months and she's just been horrible and she's feeling fine.
Why binders and VIP fall short 35:49 And I'm like, it makes sense with the what VIP does. 35:53 So she was good. 35:55 But she says, oh, you know, VIP it better. Boom. 35:58 It just said it like this. 35:59 Which the last thing you want to do it does exactly. 36:03 It stimulates the, immune response 36:07 is, which is the same thing as T-cell exhaust, 36:11 immuno senescence and what you don't want, but it can make you feel better 36:15 in the short run. 36:16 But in the long run, it's a negative. 36:18 But then and I would would say 36:21 that they're the one of the theories is, is 36:25 that with chronic inflammatory response syndrome, what happens is, is that 36:32 at a genetic level, 36:33 the transcriptome gets upregulated and all of these inflammatory genes. 36:38 And so then what we find is, is that, it's almost like we got driven 36:44 into fight or flight and we start to print the the more inflammatory genes 36:49 and there's this test called the gene that, we'll try to look at that. 36:54 And, and one of the theories is, is that, 36:57 if you could bind 37:01 and detox people to the point that they would be ready to take the dip, 37:05 then that would down regulate basically about transcriptome. 37:10 Yeah. 37:11 And I think the that's the thing is, when you look at the IP, 37:15 an ideal situation, it may be helpful, 37:19 but it especially about inflammation though, which everyone has, 37:24 especially given the factor beta that it sends it off. 37:28 In this you know, inflammatory T2. 37:32 But in the short run it. 37:35 Yeah, it may be good, but you know, you look at the, 37:39 genomic effects of these, you know, 37:42 bio activators and, you know, Mylan, you know, 37:48 t before Prime BG damage in, BPC, I mean, they're gonna 37:53 they're really modulating genes and that that's the thing. 37:56 And and you're I totally agree, everything's about the genome 38:00 and it's what is upregulated down regulated. 38:04 And that's really nice about the peptides. 38:05 And you look at like by long time a gene there with the upregulate 38:11 like 450 immune genes 38:14 and down regulate like you know 50 genes. 38:17 Something like that. 38:18 And and everything is epigenetic. 38:21 You know, or most things. 38:23 I mean, in the, in the long run that that is the key. 38:27 And so then 38:28 within and what a read I would say. 38:32 And I was this was kind of like my, 38:37 my thing that I wanted to say to you, 38:40 which is, is that. 38:44 I know that we both have hundreds 38:47 and hundreds of examples of just walking around our life, 38:51 and then you hear somebody go, oh, I, did all of this stuff. 38:56 And then I took VAP, and then I got worse. 38:59 And and whether they took it at the beginning, middle or the end, 39:04 even though I was supposed to 39:05 be at the end, and even when they thought they were at the end, they got worse. 39:09 Villain. 39:10 But also like Crested Genzyme again. 39:16 The, the neurological bio regulators, 39:20 when patients who are really sick start taking those, they start to feel better 39:26 and those patients start to feel better, like they, like the majority, 39:31 I find feel better, that they tend to be sort of on the anti-cancer 39:35 end of the spectrum, and they're regulating gene expression. 39:39 And I think a safer, more functional way. 39:42 People feel better. 39:43 You know, I, 39:46 I heard you give a lecture where you you told you mentioned a case of, 39:52 somebody who started to have less Potts physiology. 39:57 That's postural orthostatic hypotension when they were taking, Valen 40:02 and then I also have echoed the same thing. 40:05 I had the same thing, where we started to use by regulators 40:10 for people with really substantial, problems, 40:14 both on a long Covid and, and sort of a chronic Lyme perspective. 40:19 And so then I, I just, I was like, oh, this information has to get out 40:25 because I think it's an alternate perspective on how to think about stress. 40:31 And, and then the, 40:33 the intriguing aspect is, is that the peptide 40:38 component of treating Sirs is actually moved up to the front 40:43 because we're trying to 40:44 regulate at a, at a epigenetic level 40:47 and at, at at cell physiology immune level. 40:51 And then that really is the foundation of where 40:56 I think we should be thinking about these complex problems. 41:00 I, I totally agree. 41:01 And and that's the key word foundation of and that's the thing 41:05 I'm like, damn, this is become the foundation of everything, you know. 41:09 And whether it's, you know, it's talking about the patient 41:13 to call the Alzheimer's and, all these, whether it's neurocognitive disease, 41:17 autoimmunity, serious, chronic Lyme is affects the immune system, 41:23 you know, and you can do these things right off the bat, totally safe. 41:27 We have, the risk of side effects is so low 41:31 and and I think that's the word that has to get out. 41:34 You're right. 41:35 And it's changed our practice. Like, I can't 41:39 fathom 41:40 not using peptides to treat patients, you know. 41:43 And yeah, there's other treatments and I love ozone and 41:46 but they are all the all my favorite treatments are immune monitoring. 41:49 It turns out right. 41:51 Yeah 100%. Yeah 100%. 41:54 So then what. 41:59 Clue clue us in. 42:00 Because then we could go down this road a little bit. 42:03 What is immune modulation? 42:06 Because then in a way, all of your favorite treatments. 42:08 And then this is really the foundation because if somebody is out there 42:13 sick and really struggling, then what you're hearing is, 42:18 is that at the beginning, we're thinking about 42:21 modulating your immune system as sort of step one. 42:26 Take walk me down that road a little bit. 42:28 Yeah. 42:28 And has anyone talked about that in the 42:31 in the summer we're going to talk about it better. 42:33 So just keep go all the way and here's a link. 42:35 But yeah. 42:36 And then so I have an e-book that I'm finishing up on Sears, but it really can. 42:42 They are, the Myanmar auditory Treatment of seizures or rapid treatment 42:46 series, whatever is going to be called. 42:47 But, so I'm finishing it up for, for a year summit. 42:52 And it really talks about how to, how to focus on this with, with peptides. 42:56 And but you can replace really serious with anything. 42:59 Honestly. 43:00 And it's really me and Marjorie. 43:04 So I kind of, you know, I do this so much, you know, 43:07 with the, the one you can really tell the health of the person. 43:11 I'm telling you, if you check their one day to heal, 43:15 immune system, that will tell you how healthy or sick that person is. 43:21 And, you know, you look at, 43:23 we're getting better test, but that triggers a function. 43:25 You know, you look at, in efecto, potentially as well, you know, how many, 43:32 infections they have and, also thyroid, 43:35 but and then the C4, a and you activate, and we also we find, 43:41 I mean, all these patients have immune activation regulation 43:44 and they have, you know, D-dimer super high, like long Covid 43:49 and see they all fit in this same pattern. 43:53 Long Covid is just like Lyme. 43:56 It's just like, you know, autism actually, and, and all these things. 44:01 So is that the immune system we have low 44:06 one H1 two or you know, there are balance in this article like this. 44:10 As you age from aging and involution of the thymus. 44:14 So the thymus in balloons and causes aging, you look at even 44:19 the CDC, states that 80% of age related illness, 44:25 sorry, 80% of people have at least one, 44:29 age related illness, which is due to the evolution of the thymus. 44:33 That's the CDC. 44:34 Okay. 44:35 If that's the case, why wouldn't you either? 44:38 Okay, rejuvenate the thymus if you can or give thymic peptides 44:44 like and prevent 44:46 the cause of all these age related illnesses right there. 44:51 The CDC says 80% of people have at least one age 44:55 related illness due to thymus involution. 44:58 Why not give thymus back to the patient, right, and fix that? 45:03 A meme system. 45:04 And you know, and you look at so it it's it's hard to believe 45:08 our, you know, nine 1012 but then drops around 1240 45:13 and that's all of a sudden you start getting all these diseases of aging, 45:17 whether it's, you know, cardiovascular disease, autoimmunity, cancer, 45:23 and, you know, there's a little lag in the medicine below. 45:26 And then it goes up, why not give the stomach peptides back and prevent that? 45:31 It just seemed like, hello. 45:33 Like it's a no brainer. 45:36 Almost like if you're if something else was really low, 45:40 if your testosterone was 50, we would support that testosterone back up. 45:45 If you're if you have no immune support going on in your body, 45:49 then ammonia is going to be the old man's friend. 45:53 But why not just lift your immune 45:56 support up and then suddenly, maybe there's no problem, right? 45:59 Unless there's. 46:00 Because big Pharma doesn't have a drug for it. 46:03 So they say, well, it's normal to be low like you do with testosterone. 46:08 Just keep lowering the normal range. Right, right. 46:11 And 46:14 and but unless it's, they have like a statin for cholesterol, 46:18 which they don't go by normal anymore, they'll go by to a normal level. 46:22 They take the population lowest, 2.5% and highest two and a half. 46:26 Those are abnormal. The rest is normal. 46:28 But with statins, they don't do that with cholesterol. 46:31 They don't do that because they have a statin to treat it right. 46:34 So they do optimal. 46:36 So really we should be looking at optimal. 46:38 But they would say that well it's normal to have low thymic function. 46:43 So you don't need dynamic peptides right. 46:46 But it's also normal to get cancer cardiovascular disease. 46:48 So don't treat those right. 46:50 So it's just it's hypocritical. 46:52 But unless you have a drug to treat it which 46:56 you know again with like cholesterol and stuff like that. 46:59 So they say what's optimal instead of what's normal. 47:02 And but with dynamic peptides it's yeah replace that. 47:08 You just anti 82%. 47:09 And you look at EPA talent combined with the thymic peptide. 47:14 Oh my gosh, the anti-aging effects like you know looked at people 47:18 with cardiovascular disease over 15 years with significant cardiovascular disease. 47:24 They gave them actually only six doses 47:27 of peptide and the pineal peptide and followed them. 47:31 And the people with significant cardiovascular disease, 47:34 the people that were on visible decline, 47:37 and the people on the two peptides just for six doses, 47:43 actually had improvement, 47:44 their cardiovascular symptoms, improvement in their quality of life, 47:48 dramatically less cancer, dramatically less cardiovascular events. 47:54 And then 47:55 the people that they actually gave further doses to, 47:59 they had a fourfold decrease in cancer and part of vascular disease. 48:04 I mean, it's just crazy. 48:06 And the stuff is so safe. 48:08 Are you talking about cabins in here? 48:10 Yeah, he's the greatest. 48:13 I think he's he's just like, one of the ten 48:16 most important doctors in the world for sure to me.
Peptides as immune modulators 48:20 And then what will happen is, is people are not going to be really aware of this 48:24 and for like another ten years, but it's just going to 48:27 his importance is going to grow over time. 48:30 I think. 48:31 So you're not important till you're dead. 48:34 Yeah. 48:34 But I maybe hopefully he's gonna stick around for a super long time. 48:38 So, Yeah. Well, that's my blessing. 48:41 Yeah, that's my wish, Professor Evans. 48:42 That, he should be taking the peptides. 48:45 It'll be like Yoda. 48:47 That's right. 48:48 But so then that that, 48:51 indicates a point that, 48:55 that maybe if, if that 48:57 immune, component is being supported 49:02 and then you're hearing that people have less cardiovascular events. 49:05 That's because cardiovascular disease is immune disease. 49:08 It everything's immune disease. 49:11 I promise you. 49:14 And so then within that then, 49:19 one thing that I'm 49:21 beginning to sort of talk to a lot of people about is, is that, 49:25 does that mean you need to be on thymic peptides all the time? No. 49:29 Okay. 49:29 Even just all the short boluses seem 49:32 seem to have some support, but so then, you know, 49:36 there's a lot of people that I work with sort of feel great most of the time. 49:39 But then something happens and the wheels are coming off the bus. 49:44 And so then being able to sort of manage through those moments and, 49:49 and there can be multiple things impacting that. 49:53 But then from a thymic, peptide perspective, 49:58 then, you know, you're one thing to think about a science novel, one 50:02 one thing to think about is the, the immune bio regulators. 50:07 Think again Christian Bale 50:09 on a one thing to think about then 50:13 and I don't really use thymus and beta for any anymore. 50:17 I'll use the fragments because I think the fragments are, more 50:22 anti-inflammatory, more potent, and, because 50:27 the tb4 is 50:29 basically a number of different peptides combined that it, 50:34 it has a section like the TPA for active. 50:37 Right. 50:38 AC as, DP, 50:41 you know, that we, integrated peptide cells 50:44 that that will lower growth, activate, immune monitoring. 50:49 But then there's a section on the TV for that actually stimulates 50:53 mast cells, is inflammatory. 50:56 And then they have and you look and you go through there some other domains 51:00 and then ages at the other end is also another one that is very rejuvenated. 51:06 So it's really a number of like five peptides combined. 51:11 Right. 51:11 And so then why not isolate down and take the one that you want. 51:17 That's that, that was I was that was, that was leading up to have you say that 51:21 because you and you've, you've used that, 51:24 you've used the time of some data for fragments a lot. 51:30 Yeah, yeah. An integrative peptide has that. 51:32 And then they're coming out with the aids, which the other, other, end of the, 51:38 the N-terminal to the C femoral, which is shown to be very rejuvenated as well. 51:42 Yeah. 51:42 So take the parts that you want and leave the parts you don't. 51:47 And the and now interestingly, because on the peptide front the 51:52 this this kind of dovetails into an interesting topic because 51:56 peptides are proteins and so big proteins, if you take them in your mouth 52:01 they're just going to get chopped up and absorbed, 52:04 which is why you you can't take insulin by mouth. 52:07 You've got to inject it with an insulin syringe. And 52:12 there's, 52:12 good bioavailability when you're injecting peptides subcutaneously. 52:16 But the small peptides and then especially either the fragments 52:21 or the, via or the via regulators or some of the other ones, like CPGs. 52:27 Okay. 52:29 I think are the, the best peptides. 52:31 There's less immune reactivity to them. 52:34 They they are better at regulating at an epigenetic level 52:39 because those are the ones they're going to go in 52:40 and actually have an effect at the genetic level in terms of the transcriptome. 52:45 And and then finally you can take them orally. 52:49 Yeah. And, and that's the thing. 52:51 So there is when they're like, 52:56 the BPC is kind of an anomaly that it's, 52:59 you know, 14, amino acids, but it absorbs 53:03 orally, whole and, 53:06 as long as it is, has a C related. 53:11 Right. 53:11 And there's the stable BPC, people are saying stable, 53:15 but if you have, salt like the, the body will naturally see the like 53:20 something that it wants to protect against, against enzyme degradation. 53:26 So if you don't acetylation it then it gets broken down. 53:29 So it's interesting to me that they're saying, you know, stable BPC. 53:33 And because the stable in the gut, at, you know, at very low pH, 53:38 but there's so many studies of BPC, see, it has been stable in the gut 53:42 for 24 hours or more, but they just happen to find out that it they say it's not. 53:48 But if it's not a C related, it's going to get broken down very quickly 53:52 by the, digestive enzymes in the gut. 53:55 But they're calling it stable BPC when it's really unstable. 54:00 BPC yeah. 54:01 And BPC will absorb whole, 54:04 TB for frag will absorb whole. 54:09 And it's interesting. 54:10 So the Cfpb so there's a nano 54:13 Cfpb coming out that is 54:19 ultra but not all true. 54:20 If you alter it it becomes a drug. 54:21 But that it is 54:25 like 100 times more potent, which is a very interesting. 54:28 And the body would do that on its own. 54:30 But you got to know what it did to do that. 54:33 So, KB, I love 54:36 and I always said it is going to be the best selling 54:39 and and it, it was huge, but now it's going to be a game changer, 54:45 I think with the super potent KB that's resistant to degradation 54:51 and, attach the receptor with 100 times affinity 54:55 and then talk to me, tell me about Cfpb 54:57 and just sort of like what as a peptide how how you think about that. 55:01 So so Cfpb is a fragment of MSH. 55:06 Well as I said, learning hormone, which you know, Shoemaker, 55:10 you know, talks about the anti-inflammatory work, 55:12 which is a core issue with his, with the whole protocol that he says is low. 55:16 Right. 55:17 All the things he does is trying to increase MSH in the Shoemaker protocol. 55:22 Right. 55:23 So. Well, if you can't give MSH, you can't one. 55:27 It will be broken down very quickly. 55:30 You get stimulation of melanocytes, which is sounds good. 55:34 You know, you get an atom one and two which are, 55:38 basically analogs of that and stimulates it. 55:41 You know, they called the Barbie doll peptide because you get reduced 55:45 inflammation, you get weight loss, you get increased libido and you get ten. 55:51 But it's great if you're young, but if you're older, you get dark spots 55:54 and all these things. 55:55 And I are taking it. 55:57 I'm A.D.D., so I'm like, this isn't working. 56:00 And all of a sudden I was, oh my God, I was so black. 56:03 I don't think, oh, my God is so weird, but, and a lot of like, I know Corey 56:07 Jr, talks about, you know, why somebody's arm and giving it 56:11 and, one at a time, one and two for Lyme patients. 56:14 You for a long time. 56:15 But and but you're getting that double edged sword 56:19 now you got you know, now they're all blotchy and stuff. 56:22 But k-p-d, 56:25 it's about, you 56:26 know, it's substantially more potent 56:29 and doesn't cause stimulate the melanocytes, but dramatically lee 56:34 anti-inflammatory but it also does not decrease. 56:38 It's like not giving up. 56:40 So steroid it increases the body's ability to fight an infection. 56:44 And it has huge antimicrobial antimicrobial effects. 56:49 Antiviral, antiparasitic, antibacterial. 56:52 It is like the ideal peptide that everyone should take. 56:58 And it's, 57:01 I think it's going to 57:03 like, just change the lives of so many people. 57:05 And so, the standard Cfpb is who has been out. 57:10 But it just it a run on. 57:12 And when that IP ran out 57:16 but they're going to get they should be in a week or two 57:21 hopefully for a for him. 57:24 Getting the, the potent version. 57:26 In fact I'll send you some I'd love to see what, what your thoughts are. 57:30 Because, I, I 57:34 when it just like it literally 57:36 this is going to be the best thing for so many people, but yeah. 57:40 So that that's going to be very anti-inflammatory being mandatory. 57:45 But they all work together. Right. 57:47 And and then you look at, you know, looking at the, 57:51 bio modulator defining peptides with the pineal peptides, 57:55 and then you add, you know, BPC, Cfpb, 58:00 and lower that inflammation. 58:02 Then you let's say they have sleep disorder, you know, delta sleep inducing 58:08 peptide mitochondrial dysfunction at a mitochondrial, 58:12 you know, not C ss 31. 58:15 And also you look at protecting against mold. 58:20 And Michael toxins. Right. 58:22 So the peptides will not only treat it but they'll protect you 58:26 and not allow the effects of the mycotoxins. 58:31 You know, increase IL six and, you know, 58:34 all the oxidative stress, the peptides will prevent that. 58:38 And also even, you know, activating the calcium channel, 58:43 and the basically, 58:47 we see what the MPs will stimulate calcium channel, the calcium channels 58:51 where you get flood of calcium in the cells, you get, you know, palpitations. 58:55 In fact, my, stepson, 58:59 he sorry, getting palpitations and racing heart. 59:03 And the Wi-Fi is right in his room, you know, and I'm telling people, 59:07 at minimum, turn off the Wi-Fi at night, you know, just unplug it or whatever. 59:12 And we did that, and then it stopped. 59:15 And, I've heard that. 59:18 I have heard that that's, I think that that's a big one. 59:22 Yeah. And electric cars, 59:25 it's like you're 59:26 driving next to a high tension wire, you know, and, 59:30 I have some case studies showing that people didn't get better. 59:34 And then I'm asking what car they drive an electric car, 59:38 and they stop and they get better. 59:42 That's interesting. 59:43 When I've, We'll have to keep a conversation on that going. 59:48 On a scale from 1 to 10 of being helpful 59:50 for mast cell activation, where would you put TPV? 59:54 9.5. 59:58 Really? 59:59 What do you think the mechanism of that is? 1:00:01 I think direct, suppression of NASL and also, 1:00:07 I mean, monetary. 1:00:11 So then that's so awesome to kind of think about 1:00:15 because the, the two things, the, 1:00:18 you know, that I think 1:00:22 a lot of patients with complex illness are struggling with. 1:00:27 Is pods. 1:00:29 They, they stand up and they get lightheaded 1:00:32 and their heart rate goes discombobulated 1:00:35 or they get mast cell activation. 1:00:37 Tell us what mast cell activation is 1:00:41 because that's a that's a useful one to for people to hear about. 1:00:45 Yeah. 1:00:45 And so the thing is with mast selectivity. 1:00:47 So mast cells are the cells 1:00:50 that will go in when you have injury or infection. 1:00:55 I mean they're good to and that's the thing. 1:00:57 Everything's a balance right. 1:00:59 Is that they stimulate inflammation 1:01:03 and they'll actually we 1:01:06 a lot of things that they, they weren't involved with 1:01:10 because they would basically, have basically, you know, 1:01:17 packets of histamine and they say, well, you know, they would release histamine. 1:01:21 That's what they thought their, their function was. 1:01:23 But it's not a lot of times they don't be granular at the histamine, 1:01:27 but they just they secrete a ton of inflammatory cytokines. 1:01:31 Right. 1:01:31 And so you stimulate the mast cells 1:01:34 and it just causes all this inflammation. 1:01:36 And this, 1:01:38 one 2017 shift in immunity. 1:01:42 But, you know, they thought it was always just mast cells were allergy, 1:01:45 but now they are way more important than that. 1:01:47 So NASA activation has, you know, all the symptoms 1:01:51 that you can pretty much imagine with, with everything. 1:01:54 And I think mast cell activation has a place in, 1:01:57 you know, chronic Lyme disease certainly sears all those things. 1:02:01 And the doctors who are experts on this and, 1:02:04 you know, with the Mast Cell Mastermind group, 1:02:07 some in the most intelligent doctors I've ever met.
Mast cells, POTS, and mitochondrial support 1:02:11 And but they're just stuck on directly stimulating them, 1:02:14 like inhibiting the mast cells. Right. 1:02:16 Look upstream because the biggest proportion 1:02:20 of the mast cell, similar to the mast cells, aren't abnormal. 1:02:23 The mast cells are. 1:02:24 They're not dysfunctional. 1:02:26 They're not crazy. 1:02:28 It's what's stimulating them. 1:02:30 Right. 1:02:30 So you want to look upstream and stop the stimulation, not 1:02:35 direct. 1:02:35 Yeah. 1:02:35 You can certainly you want to direct and suppress the stimulation of them. 1:02:39 But it stopped the stimulation. 1:02:41 But they just, you know, they're stuck, in here. 1:02:45 And so you manage the immune system. 1:02:47 It's just like, you know, part series or a marcel symptom. 1:02:51 You know, the, 1:02:54 you know, bladder, all that stuff. 1:02:57 And there's so many gastrointestinal is. 1:03:00 You fixed the immune system. 1:03:01 I don't even think about, like, pots anymore. 1:03:04 It's like people have pots, like, okay. Yeah, that will get better. 1:03:06 Okay. That's where it did it. 1:03:08 You know, and it just goes away because you treat the immune problem, 1:03:12 the mast cells dramatically get better. 1:03:15 So it's I rarely, you know, 1:03:18 I'll maybe give them Claritin to start with is just to do it. 1:03:22 But it's you look upstream and that's the key. 1:03:26 And, and there's, 1:03:29 host 1:03:31 of all of these medications that are histamine blockers like Benadryl 1:03:35 and Claritin and, and then, and then a whole bunch of other categories 1:03:39 of medications that, treat, 1:03:44 and, and, and calm down and stabilize mast cells. 1:03:48 But then also, I 100% agree that, 1:03:52 if you start to work at a cellular level 1:03:55 and upstream, and, 1:03:59 and I think that's part, 1:04:02 that's part by a regulator, that's part and things like CP v, 1:04:05 that's part of things like sort of the small fragments 1:04:09 that's even I think things like 1:04:12 K are help like, 1:04:16 yes, I think g k is, is pretty amazing, you know. 1:04:21 And it, it suppresses inflammation. 1:04:24 And I think that's going to have a bigger place. 1:04:27 It's more cosmetic right now. 1:04:29 But I think, it is 1:04:33 going to be a bigger player in anti-inflammatory. 1:04:36 Respects. I, I totally agree. 1:04:39 And you know, doing injectable 1:04:42 looking at, oral, like 1:04:46 we don't have the data right now to show that it can absorb, transdermal. 1:04:52 It seems to get through, depending on what study you look at, you know, but, 1:04:57 I think that's a huge, beneficial peptide as well. 1:05:04 And then we're going to 1:05:07 start to teach about what you can do 1:05:08 with all of these things from an intravenous perspective. 1:05:12 And, you know, there's, 1:05:15 you know, where 1:05:16 I would say the exciting thing is, is that we're really having 1:05:19 an international conversation at this point. 1:05:21 And then we're we're working with clinics and, and, 1:05:25 you know, multiple jurisdictions. 1:05:27 And so then, the, 1:05:30 the intravenous use of peptides is going to be, 1:05:34 I think, one of the defining game changers in terms of how we manage. 1:05:40 And I think that as we, embark on that, we're going to work, 1:05:45 we're going to have a lot of success, and it's 1:05:49 going to be it's it's easy. 1:05:52 It's it's it's so much easier to do 1:05:55 compared to a lot of the approaches that have been tried. 1:05:59 The traditional tried and true approaches of 1:06:02 antibiotics and things that that really disrupt 1:06:07 our internal biology in the process of getting better versus 1:06:11 just like little small influences that are working at a cellular level to 1:06:16 I love that you mentioned the the mitochondrial, you know, and 1:06:21 I don't know if you want to go into that a little bit more because I, 1:06:24 I feel that all of these, all of you, 1:06:29 we mentioned all of these things that can impact biology, 1:06:33 but they almost all drive mitochondrial dysfunction in some way. 1:06:37 And then if you have it and and even infections can steal energy from 1:06:42 from basically mitochondrial pathway, it goes hand in hand. 1:06:46 And you look at every illness, every age 1:06:50 related every, ability diabetes, 1:06:54 you know, neurodegenerative diseases especially 1:06:58 they all have mitochondrial dysfunction, all of them. 1:07:01 And so you look at, you know, look at the cell danger response. 1:07:04 And that is looking at that specifically. 1:07:07 But it just goes along with with everything. 1:07:09 And you modulate immune system. 1:07:12 You're going to get significant improvement in the mitochondria. 1:07:15 But why not also give mitochondrial peptides 1:07:20 and and things like SS 31 1:07:24 mods will protect the body from toxins like mold, you know, or line 1:07:31 and it will prevent that, or treat it if you have abnormality. 1:07:35 But it is a component of every illness. 1:07:38 They all have mitochondrial dysfunction and which also causes you know, 1:07:41 I've written all these review articles on low thyroid. 1:07:44 And but the issue is not the fibroid it's mitochondria dysfunction. 1:07:49 And you can't it's active transport into the cell. 1:07:52 So you don't transport especially T4 and less so T3 1:07:56 is because the mitochondrial dysfunction. 1:07:59 So it's I have this whole review on thyroid 1:08:01 but it's really about mitochondria. 1:08:04 You fix the mitochondria. 1:08:05 Your thyroid is going to be fine. 1:08:07 And as you, 1:08:10 you know, I've, I've spoken to so many patients 1:08:15 who sat out, who talk about fatigue 1:08:18 and then and then why do we have fatigue? 1:08:21 Because we have mitochondrial dysfunction. 1:08:23 And so then, you know, I spoke to so many people who said, oh, 1:08:26 yeah, I started taking SS 31. 1:08:29 Then I started feeling better. 1:08:30 And then part of that is, is that your energy comes up 1:08:34 and then things that regulate immune function, immune peptides 1:08:38 regulate that stem cells modulate the immune response. 1:08:44 Other cells that can be given can regulate immune response. 1:08:49 Exosomes or these cellular growth factors can regulate immune 1:08:55 immune function in response. 1:08:57 And so then suddenly begin to realize, 1:09:01 oh, we we have almost like a whole bunch of control panels and dials 1:09:06 where we can begin to carefully start to track numbers 1:09:10 and then manage that immune response, manage energy, and then kind of dial 1:09:15 people into feeling basically good and balanced and clear 1:09:19 and basically 1:09:23 the the thing 1:09:24 that I figure it out is once you do that, then all of a sudden 1:09:28 you basically feel good and then you start making great choices in your health. 1:09:32 It's like a now it is true when you if you don't feel good, 1:09:35 you just don't make the choices. 1:09:37 Period. 1:09:38 You know, and, I think it's totally true. 1:09:41 It's like I used to say when I first started integrative give gimme T3. 1:09:46 You know, basically, could help so many patients, right. 1:09:50 And then and now it's really giving peptides, 1:09:55 number one, some ozone, 1:09:57 stem cells, T3, maybe a little heparin. 1:10:02 We you can you you're in a fix. 1:10:04 You know, 80% of the people that have seen 1:10:07 15 doctors, you know, 1:10:10 now, that one was one. 1:10:11 And I it's a crucial, 1:10:15 crucial piece to think about in the arc of 1:10:19 that whole conversation is that 1:10:23 if you get in these infections, 1:10:26 then your immune system is overactive and it's making too many antibodies, 1:10:30 and it's kind of already to go fight that, 1:10:34 that, that infection 1:10:37 that realistically is not like a sepsis. 1:10:40 It's not an out of control infection. 1:10:42 It's a stealth infection that's just hiding out and and triggering you. 1:10:47 And so it triggers this overactive immune response, 1:10:50 which is why immune regulation is central to our perspective. 1:10:56 Now one thing that can happen is your mitochondrial does function low energy. 1:11:00 You feel terrible. 1:11:02 Another thing that can happen is things like pots and mast 1:11:05 cell activation, which can kind of derail your life in terms of feeling okay. 1:11:11 But then, 1:11:13 and this might could be like a final little theme for us to think about. 1:11:17 And you, you reference that. 1:11:19 But let take me through the hyper coagulant ability 1:11:24 that so many of these people have, which is why you mentioned heparin, 1:11:28 because the the blood becomes thick and then there's 1:11:32 a whole bunch of consequences to that. 1:11:34 And, and then that's an important piece of the puzzle 1:11:38 to pay attention to as we as we go through. 1:11:41 Yeah. 1:11:42 And, and so you mentioned is that, you know, chronic stimulation. 1:11:46 You get this, you know, reactivated infection, chronic stimulation. 1:11:50 And so that is the key 1:11:52 is if you still have chronic stimulation of an infection or toxin 1:11:58 and what the body's immune system does, 1:12:01 it downregulated one unfortunately. 1:12:04 So it's called, you know, T-cell exhaustion. 1:12:07 And it totally is. 1:12:10 Will happen when it matters the amount of the, 1:12:14 stimulus and the length of time. 1:12:17 So if, let's say you get a viral infection and your body gets 1:12:21 rid of it like it normally does, that doesn't happen if it doesn't, 1:12:24 for whatever reason and continues on, the T cells shut down. 1:12:31 So you get T cell exhaustion. 1:12:33 And that's what you see with all these chronic fatigue syndrome patients, 1:12:37 chronic Lyme mold patients, they all have T cell exhaustion. 1:12:41 You know, they also over time 1:12:43 get immuno senescence, which is a little different mechanism. 1:12:48 But where T cell exhaustion takes weeks to months, immuno senescence takes months 1:12:54 to years and occurs with aging, which you'll see like with diabetes. 1:12:59 Hartville your that the cells 1:13:02 they they don't die like they should normally. 1:13:06 That one sounds like natural killer cells will kill the cells 1:13:10 that are dysfunctional. 1:13:11 But if that's low, they don't. 1:13:13 So they hang around and they're not functional. 1:13:15 But not only just not functional, they get mitochondrial dysfunction. 1:13:20 And which then causes the mitochondria not to make energy, but to start 1:13:24 secreting all this reactive oxygen species and inflammation. 1:13:28 So these cells get, basically start 1:13:32 pumping out, inflammatory, 1:13:34 cytokines, and then it recruits other cells becoming senescent. 1:13:38 So they found that, for instance, the set of lytic which you kill, these 1:13:44 help the body kill the cells that are, in senescence, 1:13:49 that, all of a sudden you get heart failure. 1:13:52 Like 50% of the cells are immuno senescent, their cells and senescence, 1:13:56 and you kill those now that it starts working and reverses diabetes. 1:14:00 So there's so much money being put into this. 1:14:03 Basically set analytics that are killing that. 1:14:06 But what's the key to that? 1:14:07 Is that one needs to be high. 1:14:09 And so the body's not killing those. 1:14:12 And also with T cell exhaustion 1:14:16 it's the same thing but more short term. 1:14:19 But you can rescue those cells. 1:14:21 But they also they both have mitochondrial dysfunction. 1:14:24 And so fixing that is if you can stimulate them to improve 1:14:28 you can actually reverse the situation. 1:14:32 But so really the immune modulation is key 1:14:37 and it's the problem is, is that when you get it's very interesting. 1:14:42 And the studies are showing that if you get rid 1:14:44 of this infection or the toxin or whatever it is, you're fine. 1:14:48 But if it goes on now, you're get worse. 1:14:51 And so it's like a vicious cycle. 1:14:54 And then what? What? 1:14:56 And I think that like you'll hear we had a patient 1:14:59 that, was, a really nice person. 1:15:03 I had dinner with and then got a Covid vaccine 1:15:07 and, her had a fairly big 1:15:10 neurological thing, but, just thought I shouldn't say anything. 1:15:15 I gotta just keep doing it. 1:15:17 And so then the time came for the booster and then got a booster, 1:15:20 and then three hours later, had a stroke. 1:15:23 And I think there's a, significant 1:15:28 percentage of people who are somewhere on the spectrum of chronic illness that 1:15:33 because they're in a hyper global state, they're they're making treatment. 1:15:38 Their blood is thick, they're very susceptible to forming clots. 1:15:42 And so then doing, you know, we're talking a lot about managing
Coagulation, heparin, and peptide strategies 1:15:48 and modulating immune response, but then doing something 1:15:51 to think about how thick the blood is, I think is going to be and is. 1:15:55 Sorry, I didn't even answer the question you asked me. 1:15:57 Yeah. So what happens with this? 1:16:00 You know, basically the immune system causes immune activation of coagulation 1:16:04 in like, overwhelming number of patients. 1:16:08 So the body has developed this it it actually works to kill infection. 1:16:14 So it will lay down fiber and and trap the infections underneath the fibrin 1:16:19 and secrete secreting antimicrobial peptides into that layer on the vessels. 1:16:25 Right. 1:16:26 And so it will do that which is good in the short term and beneficial. 1:16:31 But over the long term, also I, Lyme and a number of infections 1:16:36 have developed ways that they either 1:16:40 cover themselves with fibrin and the body doesn't see them 1:16:45 or they'll stop, the coagulation process at a certain point. 1:16:49 So they don't they don't get trapped in that thing or, 1:16:53 basically stimulate it where it kind of bypasses. 1:16:56 So it's the coagulation is part of our immune system. 1:17:00 Right. 1:17:01 And so about 90% plus, 1:17:05 patients, chronic Lyme series, you name it. 1:17:08 Even our general diseases have immune activation regulation. 1:17:12 So the body lays down this fibrin, 1:17:15 which is beneficial in the short term and long term. 1:17:17 Now it's the body can't get at those infections 1:17:21 if they're able to resist all the, basically way that the body use that 1:17:26 to kill them, that they've, you know, evolved over, over the millions of years 1:17:31 and also nutrients can't get in therapeutics 1:17:34 can't get in, supplements, hormones, waste products can't get out. 1:17:39 And oxygen that usually takes two seconds. 1:17:42 Can cells now can take take up to two minutes. 1:17:47 And and so you look at the these patients that nothing works on them. 1:17:52 Right. Then you treat them with heparin. 1:17:54 You know, some basically, you know, 1:17:57 and enzymes and we break that down. 1:18:01 But all of a sudden, the things that you used before 1:18:03 that didn't work now work because they're they're actually getting in, 1:18:07 and you can do a little it's not, 1:18:10 totally perfect, but you can, 1:18:13 it's kind of like a party thing, but 1:18:16 but take your patient, put the pulse ox on them. 1:18:19 Right. 1:18:20 And they'll be like 100% water. 1:18:21 That's great. 1:18:22 But then you have them blow out all their air and hold their breath. 1:18:28 And when they do that. 1:18:30 So a normal person wants a healthy person, they will always after, you know, 1:18:34 a period of time will start dropping right. 1:18:37 And because the, the oxygen is cut off, going from, you know, you're not 1:18:41 breathing. 1:18:42 So going into the blood and then it should go into the cell. 1:18:45 So the blood coming back is low. 1:18:48 But people with the coagulation defect, you'll find that it doesn't drop or very 1:18:53 little like a normal person will drop like 15, 1:18:56 20, points on the, pulse ox. 1:19:00 But we have this coagulation like, drop, like 1:19:03 five points or less and, like, you know, that's good. 1:19:06 They got blood, they got oxygen, their blood. 1:19:08 No, it's not getting into the cells. 1:19:11 Yeah, this is an interesting theory. 1:19:14 But then eventually, if they hold their breath long enough, 1:19:16 then it will go off the cliff. 1:19:18 No, it doesn't. That's the thing. 1:19:21 Well, I mean, if they hold their breath long enough of it. Yeah. 1:19:23 Then it's big trouble. 1:19:25 But, it's interesting, and it it's, you know, 1:19:28 it depends on the of the person, but it it's a pretty good test. 1:19:32 But if you check, like, in the, 1:19:35 Shoemaker protocol tests, like three things that we really, 1:19:41 if you check, like, eight things, you know, eight, ten things. 1:19:44 And you'll find that really we assume everyone has it. 1:19:48 And but if they have anything abnormal, it shows and you treat it. 1:19:52 And oftentimes I've seen so many patients come in that have done 1:19:57 massive with some great doctors and nothing worked. 1:20:00 You give them a heparin also in the works also fertility. 1:20:05 Oh my God, we have so many fertility patients when you give them up a talent. 1:20:09 Right. 1:20:10 But, which shown to increase ovarian reserve, 1:20:14 we can increase, antimalarial hormone, but you give them T3 and heparin, 1:20:19 and it's people have had multiple IVF that didn't work. 1:20:25 Now they get pregnant. Naturally. It happens so often. 1:20:29 I love that. 1:20:30 And then that that goes to show that I think 1:20:36 I will use that Patel on 1:20:38 as a sort of a stress support, 1:20:41 almost like a, like a, a similar thing. 1:20:45 And, and then we'll microdose that often, you know, I mean I'll do grandma day, 1:20:49 but then I'll give ten milligrams a day during a big stress. 1:20:53 And then I found that to be fairly supportive 1:20:57 for, for a host of different things, from not sleeping to big stress, 1:21:02 it resets like so many things. 1:21:04 So in pinyin, I mean, it just, you know, there are more studies on that. 1:21:07 Patel and but carnelian, is shown to, reverse mitochondrial dysfunction, 1:21:13 predict the body against mycotoxins and which is right there with Apatow. 1:21:17 So we'll use both of those and, yeah, it's just that 1:21:21 and everything is again the pineal gland, 1:21:24 hypothalamic pituitary hormone function. 1:21:28 You know, and I think we're so kind of barbaric in that. 1:21:31 Well, let's look at cortisol level. 1:21:33 Let's look at testosterone. 1:21:35 We don't look at all these things going, you know, on the upstream. 1:21:39 Right. That's where you need to reset it. 1:21:42 And that's what these things do and which is. 1:21:44 So I'm so excited to, you know, talk about it. 1:21:47 And, I can't imagine, you know, being in California 1:21:51 where, you know, 1:21:52 it's, you know, the big pharma, 1:21:55 basically just peptides are so safe and effective. 1:21:59 They, you know, it's only state that we see disallowed a lot of them. 1:22:02 But, I'm going to go work around that. 1:22:06 But, it's game changing. 1:22:10 You know, any doctors listen to this? 1:22:12 It's like it will change your practice. 1:22:14 I would agree. 1:22:16 And so then and then it's kind of an adjacent. 1:22:19 Maybe we finish on this as an, as an a peptide 1:22:23 adjacent question because a lot of people will ask 1:22:27 about rapamycin and then about senescence. 1:22:30 And in general that a high level maybe. 1:22:34 Give me your thoughts on those topics of, of how you're thinking 1:22:38 about what, you know, herbal approaches versus meds. 1:22:42 Do you have a 1:22:43 have, how how how's that going for you? 1:22:47 And in terms of what I mean, in terms of because 1:22:49 maybe it's just started out with senescence without a license, 1:22:52 you know, so, yeah, I'm always trying stuff myself. 1:22:55 I don't believe until I try it myself, but, 1:22:59 Yeah, I think anti-aging is going to be huge. 1:23:04 You know, in the next ten years, 1:23:07 and peptides will be on the forefront. 1:23:09 And, you know, these anti-aging, effects where, you know, nad, 1:23:14 you know, boosting mitochondrial function, really pushing mitochondrial function. 1:23:18 And I think mitochondrial peptides do a better job than NAD. 1:23:22 And, I mean, all the things are good, 1:23:25 but it's like, yeah, how much stuff can you take, you know, 1:23:29 and like the, set analytics, 1:23:32 the stamina and, you know, by setting or curcumin, 1:23:37 I have to say, with the typical protocol, which they have to do 50mg, I have 200. 1:23:42 I took 200 and went 1:23:45 on it, to travel. 1:23:47 I thought I was going to die of horrible, but maybe because I have a bunch 1:23:51 of senescent cells, right? 1:23:52 You know, and, I know a doctor called me, 1:23:56 and he was, 1:23:59 they were doing, actual with it. 1:24:02 I've, 1:24:04 Dr.. Right. 1:24:06 Yes, yes, yes, yes, exactly. 1:24:08 And which I've been trying to get, 1:24:11 but I, I haven't found it, 1:24:13 but he got some they did IV and he felt horrible but not so great. 1:24:17 So and he had like diabetes or, you know, insulin related. 1:24:20 So I think he had a bunch of senescent cells and it just killed them all off. 1:24:25 And so he just felt like he was a, you know, foul verbal. 1:24:28 So yeah. 1:24:30 And and things like, you know, some peptides like, you know, the, 1:24:33 the fox, the fox, the poor, in human in I think it's going to be awesome, 1:24:38 but I can't find it less than, I mean, so expensive, you know, the dose, 1:24:43 ten milligrams a day, and it's like $300 and milligrams, you know? 1:24:48 But, I think the whole 1:24:51 anti-aging, movement is, is huge. 1:24:57 And I think it will, if they really embrace it and allow it 1:25:00 will will prevent all these like right now 1:25:04 we're on the the pathway to have 1:25:07 people just chronically ill, you know, whatever you want to call it. 1:25:12 They got chronic Lyme. 1:25:13 They got, you know, seers, they got autoimmune disease. 1:25:17 They got, you know, name it chronic fatigue syndrome. 1:25:20 And now it's just exploding right 1:25:23 then to turn that, I think this anti-aging movement, 1:25:28 which hopefully they'll allow peptides to be part of it 1:25:31 but will reverse it. 1:25:34 And then add sort of a high level. 1:25:37 If you kind of put together this conversation, I, 1:25:41 I think our goal was to talk about immune function today. 1:25:46 And I think that was a good 1:25:47 sort of introduction and a high level of thinking about it. 1:25:51 We're thinking about mitochondrial function. 1:25:53 We're thinking about senescence, we're thinking about autophagy. 1:25:57 We're thinking about kind of managing cell biology 1:26:00 and what I want you to hear about. 1:26:02 Some of those final things that we're talking about is we've got 1:26:06 yeah, we've got big meds that can affect that at, at a high, medium and low doses. 1:26:12 We've got supplements like quercetin and, 1:26:15 and, and things like that again to affect that. 1:26:18 And then you're going to have super healthy people with no problems 1:26:22 or you know, 1:26:22 you got peptides like foxo for DRI that will then take senescent cells out. 1:26:27 And so then you can impact these with healthy people. 1:26:32 And then they do it and almost nothing happens to them. 1:26:34 And sick people you do a little bit and then it can still affect them. 1:26:38 And so then now then anti-aging is going to be this thing 1:26:42 where we think about long term immune system management and modulation
Anti-aging, senescence, and GLP-1s 1:26:48 and then managing all of these aspects around biology 1:26:52 and then getting that dialed in and then just keeping that dialed in. 1:26:55 And then that's going to be like kind of the name of the game. 1:26:59 Because if you can do that, that solves like almost all the problems. 1:27:04 Yeah. 1:27:04 And the problem is with the model now is that you 1:27:08 don't get the med till you've got like they want to prove it. 1:27:12 For instance, you know, or whatever, you know, the, GLP ones, 1:27:17 unless you got diabetes, why not take it earlier and prevent, you know, it's like. 1:27:22 And I've had patients say, oh my God, I'm going to gain weight 1:27:24 so I can take this med and get it approved. 1:27:26 You know, it's like, so it's the model now is not to make you healthy. 1:27:32 It's to keep you alive after you're sick. 1:27:35 Yeah. 1:27:36 So then that's another peptide that, helps with blood sugar, 1:27:41 but kind of an amazing I've got some people have really experienced incredible 1:27:47 weight loss with that one. 1:27:49 Have you, have you also have I think it's awesome. 1:27:51 Yeah. 1:27:52 And just and I've learned too is that with the Gerd is the biggest problem. 1:27:58 And I had the worst problem occurred. 1:28:00 Let me check my H. Pylori positive. 1:28:02 And it's, you know, if, 1:28:05 if they have a problem with the gut and Gerd with it, look for H. 1:28:09 Pylori. 1:28:10 And, and H. 1:28:12 Pylori also causes immune dysfunction, you know, 1:28:16 and, it's a marker for immune dysfunction as well. 1:28:19 So, yeah, I know, I think a GLP ones are huge. 1:28:24 And then, and and then the other piece of that whole. 1:28:29 So the good thing about it, as is it's this incredible peptide 1:28:33 that helps manage blood sugar and stuff, and cars 1:28:35 can cause acid reflux, but it can also just cause nausea. 1:28:39 And so then I've also found that doing and, 1:28:43 you know, you talk to a pharmacist now like you don't need to go to lower dosing. 1:28:47 And then even doctor McElroy, was talking about like, 1:28:52 you know, he had a long experience using it at the county hospital. 1:28:56 And he says, you know, patients there just really never complained about it. 1:29:01 But then he said, you know, now people complain about it a little bit more. 1:29:04 And then we started going to lower dosing 1:29:07 and then working our way up on the dose very slowly, 1:29:11 because as a weight loss algorithm, then you're going to be on that longer. 1:29:15 And so then starting, 1:29:16 starting at a quarter a dose and then sort of working your way up. 1:29:21 May is sometimes a better strategy. 1:29:23 I know I, I think it's awesome 1:29:26 and that you find people and myself is if I'm on it, 1:29:30 I don't all of a sudden I'm like, damn, this game, you know, 5 pounds, whatever. 1:29:35 And you don't change anything. 1:29:37 And when I'm on that, my last 5 pounds, 1:29:41 you know, 1:29:41 and which results in lower inflammation, you know, other things. 1:29:46 So I think it is if it's like use right now, 1:29:50 it's like so hard to get approved unless you've got, you know, all these, 1:29:53 you know, diabetes with a kidney dysfunctional that. 1:29:57 But it should be used much earlier. 1:29:59 100%. 1:30:01 And then the and then that sort 1:30:04 of is an introduction to our next conversation. 1:30:07 Because then the, 1:30:09 the concepts that we're talking about in terms of complex illness 1:30:15 are basically the same concepts for anti-aging and the same concepts 1:30:18 for weight loss and living a long time and being super functional 1:30:22 and getting lots of stuff done. 1:30:24 And so now we just have to dial that in, and that just means optimal strategic 1:30:29 inputs early and then being being upstream and managing cell biology. 1:30:33 And the side effect of that is, is that basically 1:30:36 the the problems of our day become less prevalent? 1:30:41 I think that was a amazing, summary, 1:30:45 because it is the same stuff for we treat 1:30:49 the sickest patient is the same stuff we do for the aging patient. 1:30:55 Probably true. 1:30:56 So that was a great summary. 1:30:58 Well, yeah. 1:30:59 But yeah, you gave us a great summary today. 1:31:02 And, I'm delighted to know you. 1:31:05 And and I'm going to continue to follow everything you're doing 1:31:08 and keep talking to you because, I think, as you know, the, 1:31:13 the exciting I would say the most exciting thing for me, 1:31:17 is that, 1:31:20 you know, ten years ago was like pulling teeth 1:31:22 to try to figure out what protocols people were doing. 1:31:24 And now, you know, everybody's everybody is sharing information for the most part. 1:31:29 And then. 1:31:30 And that is going to lead to an exponential increase in information. 1:31:35 And, you know, that we're going to make the world a better place. 1:31:38 I look forward to continuing to learn and, 1:31:41 benefit from your clinical experience in the years to come. 1:31:45 Hey, thanks for having me, Matt. Awesome. 1:31:48 Awesome. Thanks 1:31:50 for.
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