Full Transcript Nitric Oxide Basics and What Depletes It 0:00 So again, if you're using mouthwash, you have to stop. 0:02 Switch from a fluoride-free toothpaste or fluoride toothpaste to fluoride-free toothpaste. 0:07 Stop using antacids. 0:09 Find a way to work with your physician to wean off of them, whether it's over-the-counter prescriptions. 0:13 And then use continuous glucose monitors. 0:16 Anything that causes an increase in blood sugar, don't do that again. 0:19 Because glucose is glue, as the name implies. 0:22 It sticks to things. 0:23 It sticks to enzymes and proteins and renders them dysfunctional. 0:28 So if you do those four things, no fluoride, no mouthwash, no N acids, and no sugar in your diet, then you've released the brakes on the body's ability 0:37 to naturally produce. 0:46 Welcome, everyone, to the Longevity Leaders podcast. 0:49 I'm your host, Dr. 0:50 Rudy Mueller, and today we have a special guest that I'm very excited to interview, Dr. 0:54 Nathan Bryan. 0:56 Now, Dr. 0:56 Bryan, I have been in your classrooms at seminars for years, from A4M to IFM to, you know, integrative in the Congress for Integrated Medicine out of New 1:10 York City. 1:11 That's right. 1:11 I have seen you and utilized your products for a while. 1:15 So it's such a pleasure to be able to actually have you here. 1:18 Thanks for following me. 1:19 It's been a journey and it's great to be with you. 1:22 So I would think that, I don't know, father, the grandfather of nitric oxide, I've been doing it a long time. 1:29 You have been. 1:31 So if you could, just give us a little bit of background on yourself, where your research, where you started out with research, 1:37 coming across nitric oxide as being an important molecule for the body, and then where we're kind of headed today. 1:43 Sure. 1:43 Well, you know, I'm a small town Texas boy, went to school at University of Texas, got a degree in biochemistry, then quickly realized the job market for 1:51 a bachelor's degree in biochemistry wasn't great. 1:53 I enrolled at LSU School of Medicine. 1:55 I completed a PhD in molecular and cellular physiology. 1:59 And it was at that time, this is the late 90s, early 2000s, and a Nobel Prize had just been awarded for the discovery of nitric oxide. 2:06 So it was an interesting time, it was an exciting time in physiology and biochemistry. 2:11 And so that's really what started my interest in nitric oxide. 2:14 I was training under a pharmacologist. 2:17 I met Lou Ignaro, one of the guys who shared the Nobel Prize, and I finished my PhD on really developing analytical methods where we could detect really
Dr. Bryanu2019s Research Journey and Discovery of Nitric Oxide 2:26 low levels of nitric oxide in biological tissues. 2:29 And then from there, I did a fellowship at Boston University Medical Center, really trying to still understand nitric oxide in vascular biology. 2:39 And then from there, I was recruited for my first faculty position at the University of Texas Health Science Center in Houston by Fred Murad, 2:45 one of the other guys who shared the no-go prize. 2:47 And so Dr. 2:47 Murad was my department chair for a number of years. 2:49 And that really started our research because I was at what's called the Institute of Molecular Medicine. 2:56 And we were charged specifically to understand the mechanism of the disease to the extent that you could develop rational therapies. 3:04 And so we started figuring out, number one, how the body makes nitric oxide, number two, what leads to a natural loss of its production. 3:11 And then once we understood that, then and only then could you start to develop rational product technology. 3:16 Or drug therapy, which is where we're at now. 3:18 Right. 3:19 And so with nitric oxide and that whole process, what particular conditions were you seeing, okay, the nitric oxide is something that we are depleting 3:29 or is a depletion of nitric oxide that may be contributing or even foremost causal or primary to this symptom sign generating? 3:38 Is there a particular thing that really jumped out at you early on? 3:41 Well, early on, the data came from in animal studies, so we could knock out the enzymes that makes nitric oxide and then look at the symptoms or the phenotypes 3:50 that develop from that. 3:52 So in a moment, if these animal models were deficient in nitric oxide, the enzyme that produces nitric oxide, they develop instant resistance, 3:59 diabetes, high blood pressure. 4:02 They seem to not perform as well cognitively in terms of maze and memory recall. 4:07 So that told us that nitric oxide was more than just a vasodilator, right? 4:11 It was an incredibly important signaling molecule that controlled a number of things from insulin signaling and metabolic disease and cognition, 4:20 high blood pressure, erectile dysfunction, exercise, and tolerance. 4:23 So those are the key observations, and then even later on, we and others discovered that there's oral bacterium that are responsible for maintaining optimal 4:32 nitric oxide production. 4:33 So then we started to interrogate, okay, what about all these antiseptics? 4:38 What about overuse of antibiotics? 4:39 What about fluoride in our toothpaste, which kills the microbiome? 4:43 So today, we understand that anything that destroys the oral microbiome, or any microbiome for that matter, causes systemic disease. 4:50 And we can partly explain that through the inhibition of nitric oxide production. 4:54 Yeah. 4:55 So early on, when first hearing about nitric oxide before hearing your lectures, it was L-citrulline, L-arginine were trying to utilize to boost nitric 5:05 oxide levels. 5:05 There was no great test to look at nitric oxide available to the clinician that's in practice every day. 5:12 So, but now, I mean, you have just hit on some amazing things here when it comes to, well, why does nitric oxide become depleted? 5:20 Or to what are some of those contributing factors in the oral microbiome being one of the major ones? 5:25 And so we realized very soon after hearing your conversation or a lecture, well, L-citrulline and L-arginine Yeah, those companies don't understand the 5:34 basic biochemistry. 5:35 Exactly, yeah. 5:36 And so there are other things that we can be doing to help support this. 5:40 And not just from, hey, take this supplement to increase your nitric oxide levels, but what is that root cause upstream driving factor? 5:48 If you're a medical doctor, nurse practitioner, chiropractor, or other health expert that's stuck in a broken system, There's a better way. 5:56 The Freedom webinar shows you a proven five step system to build a seven figure virtual health practice or how to modernize your current brick and mortar 6:08 practice without the burnout. 6:10 Learn to create high ticket programs, automated income, residual revenue, and attract clients ready to work with you. 6:18 Book your million dollar strategy session today by clicking the link in the description. 6:28 Yes, so today we look at what's disrupting the enzymatic production of nitric oxide from the nitric oxide synthase enzyme and what's destroying the oral microbiome. 6:39 And if we can maintain normal enzymatic function and we can maintain a healthy microbiome, not just in the mouth, but in the gut, 6:44 on the skin, everywhere, then we can optimize human performance. 6:49 And so if we give the body what it needs, remove from the body what it doesn't need, the body heals itself. 6:55 And medicine and science has made it way too complicated.
How Oral Microbiome Health Affects Nitric Oxide 7:00 But no, so that's what we're focusing on now is, and we certainly understand the enzymology and the biochemistry. 7:05 How do we restore and maintain optimal enzymatic function? 7:09 And then how do we maintain an optimal oral microbiome? 7:12 And many times it's not implementing new strategies, it's stopping the things that we know are disrupting that. 7:20 In terms of affecting the enzyme, we have to stop eating a high sugar, high carbohydrate diet. 7:25 Anything that leads to an increase in blood sugar, we know completely causes endothelial dysfunction and NOS dysfunction. 7:33 And then, you know, the simple things like getting rid of fluoride in your toothpaste, getting rid of fluoride in the drinking water. 7:38 If you're using mouthwash, you must stop. 7:40 And then the other big contributor to nitric oxide deficiency is RN acids, the proton pump inhibitors, the omeprazole, pentopra, 7:47 the protonics, Prevacid. 7:49 You know, these are now over-the-counter medications, and they're very dangerous. 7:52 Yeah, meant to be taken for seven to 10 days. 7:54 People take for seven to 10 years, right? 7:57 15, 20. Oh, I know. 7:58 And now the clinical data show us that people have been on these drugs for three years or longer have about a 30% to 40% increase in heart attack, 8:05 stroke, and Alzheimer's. 8:07 It's not increased risk, it's increased events. 8:10 And then mechanistically, we know that's happening because it's completely shutting down nitric oxide production. 8:15 And so how does the body convert nitrates, nitrites into nitric oxide? 8:22 Well, in the 1970s, it was the first discovery that when we consume nitrate-rich vegetables, that the kidneys reabsorb about 25% of that. 8:31 And then they intentionally concentrated in our salivary glands. 8:35 And in the 1970s, we didn't know why the body would intentionally do this. 8:39 But today we understand that there's nitrate-reducing bacteria that live on the crypts of the tongue. 8:44 And by the way, nitrate is inerting humans. 8:46 If you don't have the right bacteria and you eat nitrate-rich meals or take nitrate capsules, which many companies are selling, 8:53 you just excrete it out in your sweat, your urine, and your feces. 8:56 So in order for diet to provide a nitric oxide benefit, we must have the right oral microbiome. 9:02 Because these bacteria are converting nitrate into nitrite, and this is a two-electron reduction. 9:07 And again, with two out of three Americans using mouthwash, 99 out of 100 people using fluoride toothpaste, 73% of the municipalities in the US putting 9:16 fluoride in their drinking water, the majority of the people don't have the right oral microbiome. 9:21 So they're not getting the nitric oxide cardioprotective benefits of their diet. 9:25 And if they're taking things like beets or beet capsules or nitrate capsules, they're not getting a clinical benefit from it. 9:34 And then the other thing is if you don't have sufficient stomach acid production, you don't get the benefits of it. 9:39 And there's over 200 million prescriptions written for antacids every year. 9:43 200 million prescriptions written for antibiotics every year. 9:46 And now two out of three Americans are using over-the-counter antacids. 9:50 So the point here is that everything we're doing is inhibiting nitric oxide production. 9:56 What are the results? 9:56 Two out of three Americans have an unsafe elevation in blood pressure. 9:59 Nine out of 10 Americans are unfit, metabolically unfit. 10:02 50% of the men over the age of 40 report erectile dysfunction. 10:06 I mean, we're a mess. 10:08 And we've provided an explanation that partly explains why Americans are so unhealthy. 10:15 Yeah, and it's a lot of the removal of these things from our everyday life to be able to address it. 10:22 And so when you're testing, if you're looking at nitric oxide levels, I remember these strips. 10:29 Is that a valid way to? 10:31 You know, I developed those strips back in 2010. So I filed patents. 10:37 I was still, in fact, with the University of Texas at the time. 10:40 And in about 2012, I abandoned the patents. 10:42 The University abandoned those patents because, number one, it's old chemistry. 10:46 It's called the grease reaction. 10:48 What we're doing is looking at a diazo compound form from nitride and a sulfanilamide that turns pink upon it. 10:55 So what we're measuring is salivary nitrite. 10:58 So they're not nitric oxide test strips. 11:01 as they're advertised. 11:02 We're not detecting nitric oxide, because nitric oxide's a gas, right? 11:07 But what we thought at the time was it gives us an indication of the presence or absence of these oral nitrate-reducing bacteria. 11:15 But the challenge we ran into, and the reason I abandoned the patents, and the reason I don't use the test strips anymore, 11:20 is because if you've got an active oral infection, we're going to pick up a local immune response in the oral cavity, and it's going to turn that test 11:28 strip bright pink. 11:30 But yet people present clinically with symptoms of nitric oxide deficiency. 11:34 They may turn this test strip pink, but they've got ED, they've got high blood pressure, they're diabetic. 11:40 And so it gives them a false sense of security because systemically they're nitric oxide depleted, but in their saliva, because of an active oral infection, 11:49 they light up the test strip. 11:51 So, you know, it's still a good tool, I think, because there are no false negatives. 11:56 If you test negative and you don't turn colors on the test strip, then it tells us you're nitric oxide deficient. 12:02 But it doesn't tell us why. 12:04 Is it because you like the bacteria? 12:05 Is it because you're taking an antacid? 12:07 Is it because you're using mouthwash or fluoride or you have endothelial dysfunction? 12:11 I mean, I know how to do that. 12:12 I can interrogate that and get the answers to it. 12:14 But now these companies that are out there selling these test strips, they don't understand what they're actually measuring. 12:19 Okay, that's good to know. 12:21 Is there any test that we can look at and even if we have to infer as a secondary test to look at nitric oxide levels or is it just based off of signs 12:30 and symptoms and it's pretty straightforward that we might be having? 12:32 Well, there are some really important functional medical devices that look at what's called flow-mediated dilatation. 12:39 And so there's a number of these FDA-cleared medical devices on the market, but what it's looking at is how responsive your blood vessels are to certain
Testing Nitric Oxide and Functional Vascular Measures 12:47 agonists like shear stress or brief periods of ischemia. 12:50 So I always recommend those because those are functional tests. 12:53 They're not biochemical too. 12:54 The endoped is one example. 12:56 There's others, and that's called ischemic pletmisography, so we occlude the blood flow and the brachial artery for five minutes, 13:02 we release the cuff, and then we look at the degree of vasodilation. 13:06 And then there's some non-aschemic plenistography looking at arterial compliance and pulse wave and augmentation index. 13:12 But all of these are functional measurements on vascular health. 13:17 But what we try to preach is, pay attention to symptoms. 13:21 Because if you have ED, you have nitric oxide deficiency. 13:24 If your blood pressure is above 120 over 80, that's some degree of nitric oxide deficiency. 13:29 If you have insulin resistance, that's a symptom of nitric oxide deficiency. 13:33 But really, I tell people there's only two people in the world who need nitric oxide. 13:38 There's the people who are sick and want to get better, and then there's people who are well and don't want to get sick. 13:42 So if you fall in one of those two, then you should consider nitric oxide as a potential, not just treatment, but a prophylactic kind of daily regimen 13:52 to maintain optimal nitric oxide production because honestly, The food that's grown in America is nutrient depleted. 13:58 We're exposed to toxins, EMFs, herbicides, pesticides, environmental toxicants that are almost always kind of compromising our ability to naturally produce 14:08 nitric oxide. 14:09 And destroying the bacteria that help produce it. 14:11 And destroying the microbiome. 14:14 Very interesting. 14:16 Okay, so what are the solutions for someone that is wanting to support the nitric oxide, whether they are sick and need to get well or well and want to 14:24 avoid being sick? 14:26 What are the solutions and what are the strategies here to be able to raise nitric oxide? 14:30 A supplement, a tablet, what's your go-to? 14:34 Well, our first is always kind of diet and lifestyle, right? 14:38 Because my belief is about chemists and physiologists is if you give the body what it needs and remove from the body what it doesn't need, 14:44 there's no need for supplementation. 14:45 There's no need for drug therapy. 14:47 Let the body heal itself. 14:49 But because of the conditions we live in, that's almost You know, it's not realistic. 14:55 So again, if you're using mouthwash, you have to stop. 14:58 Switch from a fluoride-free toothpaste or fluoride toothpaste to fluoride-free toothpaste. 15:03 Stop using antacids. 15:04 Find a way to work with your physician to wean off of them, whether it's over-the-counter or prescription. 15:09 And then use continuous glucose monitors. 15:11 Anything that causes an increase in blood sugar, don't do that again. 15:14 Because glucose is glue, as the name implies. 15:17 It sticks to things. 15:18 It sticks to enzymes and proteins and renders them dysfunctional. 15:23 So if you do those four things, no fluoride, no mouthwash, no N acids, and no sugar in your diet, then you've released the brakes on the body's ability 15:32 to naturally produce. 15:34 But we can stimulate that. 15:35 We can activate it. 15:36 Modern physical exercise. 15:38 We used to say 20, 30 minutes of moderate intensity exercise a day is sufficient. 15:41 Now, you know, four to six minutes of high intensity interval training. 15:46 You increase your heart rate. 15:47 You increase your breath rate. 15:48 Nasal breathing. 15:49 You know, because we have this enzyme nitric oxide synthase in our upper airways and the epithelial cells. 15:54 And when we nasal breathe, it activates these enzymes and we generate nitric oxide. 15:58 And if we mouth breathe? 16:00 And if you mouth breathe, not only are you bypassing the sinus, but you're destroying the microbiome. 16:05 You're fully oxygenating the mouth, changing the environment, changing the ecology, and you get halitosis, you get dysbiosis, 16:12 and we know the dangers of mouth breathing. 16:15 Right. 16:15 And then the other is 20, 30 minutes of direct sunlight a day. 16:19 And then, yeah, when all else fails, we have product technology that does it for you.
Lifestyle Strategies to Restore Nitric Oxide 16:24 Okay. 16:26 So one of the things that I'm curious about when you talk about going fluoride free toothpaste, if we're trying to address the oral microbiome, 16:33 what is, is there a strategy? 16:35 Is there a toothpaste that you would recommend that helps like a prebiotic or a probiotic toothpaste or? 16:40 Yeah, I've been dealing with that for 20 years, so I've been using a non-fluoride toothpaste for 20 years, but when I looked at the ingredients on the 16:48 ones I was using, and I tried a dozen or more of these, there were still things in there that seemed to destroy the microbiome, 16:55 the biofilms. 16:56 So that's a year, well, probably two years ago, I started on this journey. 16:59 How do we develop a microbiome-friendly nitric oxide activating toothpaste? 17:05 And so I launched this a couple of months ago. 17:08 It's called Cario Smalls. 17:09 This is great. 17:09 Okay. 17:10 Yeah. 17:10 So it's fluoride-free, number one. 17:12 It's hydroxyapatite-based, so it re-mineralizes the teeth. 17:15 But we also put components in there that are prebiotics that allow for these non-pathogenic commensal bacteria to repopulate and improve the diversity. 17:24 Because in a paper we published in 2014, we showed that the greater the diversity of the oral microbiome, so we were doing tongue scrapings and then culturing 17:32 these bacteria, the better the blood pressure management. 17:36 So, how do we improve the diversity of the microbiome? 17:38 How do we improve the numbers and communities of these nitrate-reducing bacteria? 17:44 And that's the purpose of the CardioSmall toothpaste. 17:47 It's a prebiotic. 17:49 It kills the pathogens because we're providing a source of nitric oxide while you're brushing your teeth. 17:53 And most pathogenic bacteria are sensitive to nitric oxide. 17:57 It binds to the iron sulfur centers of them, shuts down the respiration, where the non-pathogenic commensal of nitric oxide producing, 18:03 so they're resistant to it. 18:05 So now we've got a solution to selectively kill oral pathogens while maintaining healthy, diverse, non-pathogenic commensals. 18:13 And we're modifying the salivary pH, which is a huge problem. 18:17 So you're getting a, you know, it's a two-pronged approach, killing two birds with one stone in the sense that you're, I mean, 18:22 yes, you're remineralizing teeth, but the focus here is killing the bacteria that can be causing a problem and getting rid of those as well as repopulating 18:31 through the... 18:31 Yeah, and creating an environment where the natural ecology of the bacteria, where the ecology can support the healthy microbiome and diverse. 18:40 So no, that's a huge undertaking for us because a lot of people aren't looking for nitric oxide products, and I think that's why education and awareness 18:49 is so important, but hopefully everybody brushes their teeth. 18:53 And these are once a day or hopefully twice a day. 18:56 So if you can now integrate this nitric oxide focused toothpaste and just replace your existing toothpaste, what we're finding is that their blood pressure 19:05 comes down. 19:06 And hypertension is the number one driver, the number one killer of men and women worldwide because if we're restoring the oral microbiome, 19:13 we're enhancing nitric oxide production and we're supporting healthy blood pressure. 19:17 So that's a major step. 19:18 And think about the public health impacts of that and the global policy and the impact, the economic burden on treating cardiovascular disease and diabetes, 19:28 which are symptoms of nitric oxide deficiency. 19:31 Then next year, I developed a mouth rinse that basically is going to do the same thing because even though the toothpaste does a very good job of freshening 19:39 your breath, improving teeth mineralization, and supporting healthy microbiome, there's still people who just want to use a mouth rinse before they go out, 19:47 before they go on a date. 19:48 They just like that feel. 19:50 Two out of three Americans are using mouthwash now that's killing 99.99% of the bacteria in their mouth, as the commercials tell us. 19:58 But how do we create a rinse that supports the microbiome, kills the pathogens, and leaves you with a fresh breath? 20:05 So we finally cracked that code. 20:06 We're doing stability studies now, but similar things. 20:09 We're finding in people who have resistant hypertension, you switch to our toothpaste, you use our mouth rinse, your blood pressure comes down. 20:17 And it's a nitric oxide related phenomenon. 20:19 I mean, that's huge. 20:20 That's huge. 20:21 I remember, you know, when we first started down this road of nitric oxide as a practitioner, yes, I mentioned L citrulline, 20:28 L arginine, but then utilizing these different tablets or capsules to try to boost it, which would give you a temporary boost,
Microbiome-Friendly Toothpaste and Mouth Rinse 20:33 but wasn't getting to the root issue. 20:36 Yes, we would have a temporary improvement maybe in our athletes and their ability to withstand an aerobic exercise because they feel better with the nitric oxide. 20:45 Yes, we have a lowering of the blood pressure temporarily. 20:48 But with this, this is getting to the root issue. 20:53 The motive is, it's very difficult to change habits. 20:57 It's the most difficult thing to change one's habits. 21:01 But implementing these very simple strategies, the things you do on a daily basis, brush your teeth, use the mouth rinse if you will. 21:08 just simply utilizing a better form of this, now your body is going to improve its ability to make nitric oxide. 21:14 And then once people see the results, it's easier to maintain these practices. 21:19 They're going to feel better, their blood pressure is better, they're going to be able to work out better, they're going to have more energy, 21:23 their sex life is going to improve. 21:24 And now they've got a motivation because they're seeing the differences, they're feeling the differences, so what did I do different? 21:30 I started this, I focused on nitric oxide production, and I'm reaping the benefits. 21:34 No, it's just replacing. 21:36 You're not having to replace it. 21:37 Right. 21:37 And that's a huge thing to add to change. 21:39 Just replace. 21:40 Yeah. 21:40 And then in the future, you know, we're developing drug therapy. 21:42 We're going to develop other products, you know, like a nitric oxide-friendly deodorant, not an antiperspirant. 21:50 But, you know, people develop... 21:53 odor because of bacteria, dysbiosis. 21:56 I haven't used a deodorant and antiperspirant in more than 25 years, and I don't have body odor because I'm supporting a healthy microbiome and I'm not 22:04 allowing the colonization of the odor-causing bacteria. 22:08 Same thing with the gut bacteria. 22:10 People who have odorous feces have dysbiosis. 22:13 And so again, understanding how do we support the microbiome instead of destroying it, it leads to overall better health. 22:21 Sure, absolutely. 22:22 Well, Dr. 22:23 Bryan, it was an absolute pleasure when you see your book here, The Secret of Nitric Oxide, so practitioner lay person friendly. 22:30 It is. 22:31 I've taken really the complex science and distilled it down into a lay version, sixth grade reading level. 22:38 But the motivation of this book was twofold. 22:40 Number one, communicate the latest science on nitric oxide. 22:43 Because as we touched on, there's a lot of misinformation out there on how do we restore nitric oxide production. 22:48 So in the book, I tell the story of what nitric oxide is, how it was discovered, what led to a Nobel Prize, and why everybody in the world should be concerned 22:57 about their own nitric oxide production. 23:00 But then in that journey, I've told my story of discovery, of how the simple discoveries and observations we've made in the over 100 peer-reviewed publications 23:10 that we've published, how that led to these discoveries to really lead to natural products that restore nitric oxide production. 23:18 And now, as we move through the FDA for drugs for heart disease, we've got a drug for Alzheimer's, and we make a topical drug for diabetic ulcers and non-healing wounds, 23:26 but really it's for so people understand, how do we go from here to here?
Book, Products, and Closing Remarks 23:31 And to build trust and show the science and the pathway that led to these discoveries, to where people know that when we develop products and we put products 23:39 to the test, that if your body can't make nitric oxide, we do it for you, but then we fix the reason your body can't make it. 23:45 Excellent. 23:45 Excellent. 23:46 Getting to the root cause. 23:47 Functional medicine. 23:48 And then even the naturopathic, it all begins in the gut. 23:52 Right? 23:53 Sure. 23:53 Microbiome. 23:54 That's awesome. 23:55 Well, thank you again, Dr. 23:56 Brian. 23:56 I appreciate all the work that you do. 23:57 I look forward to seeing where your N101 products continue to develop. 24:02 Deodorant sounds great. 24:03 Mike's son, who's 11, needs it back. 24:05 It's those early teenage years, yeah. 24:08 No, but you can get the book wherever books are sold. 24:10 Amazon, Barrington Noble, nathansbook.com will provide a link. 24:13 Awesome. 24:14 Thank you very much. 24:15 Thank you, Rudy. 24:16 Thank you for tuning into Doctor Talks. 24:18 We hope today's episode has enlightened and inspired you on your path to optimal health. 24:23 Each day is a new opportunity to make choices that empower your well-being. 24:27 For more insights and strategies, subscribe to our podcast and visit our website, www.doctortalks.com. 24:36 Stay connected, stay healthy, and join us next time on Doctor Talks, real talks from real doctors on the issues that matter to you most.
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