Full Transcript Podcast Introduction and Guest Welcome 0:00 Mitochondrial health is at the pinnacle of one of the things that we really need to be looking at. 0:05 And if you miss it, it's terrible because I've seen it where like, you look at your like functional medicine labs, right? 0:11 You look all your inflammatory and your lipids and all this kind of stuff and this person looks great. 0:16 Then you run their mitochondrial and it is horrendous. 0:20 You're listening to the Lifestyle Medicine podcast with Dr. 0:23 Ivan Rusilko, brought to you by Access Lab, where we explore new perspectives at the forefront of personalized health care. 0:33 Well, welcome back to Lifestyle Medicine Podcast. 0:35 I'm Dr. 0:36 Ivan Rusilko. 0:37 We're powered by Access Medical Labs. 0:38 And if your physician's not checking labs, they're not a physician. 0:41 Today, I've got a treat for you, Dr Poziotopoulos. 0:43 Again, that's a mouthful, but he's actually the owner, the founder, and the main man at the Pozzio Institute, which is almost as interesting as our main 0:51 topic today, just the analytics, something that I hold near and dear to my heart, what I think is the cornerstone of longevity medicine. 0:56 Doctor, thank you so much for being with us. 0:59 You're welcome. 1:00 It's a pleasure to be here. 1:01 Heck yeah. 1:02 So how is Chicago treated? 1:03 I have to ask. 1:05 Chicago is great. 1:06 it's an awesome city, you know? 1:08 Tons of culture and it is super clean and there's not too many people here and the two months of super cold keeps most of the people away. 1:17 I can't go wrong with that. 1:18 So it was funny, we were actually talking before we got this podcast, and we're talking about senolytics and kind of shooting the breeze. 1:23 And then we kind got into the positive institute. 1:25 I'm almost as intrigued in that as I am in senlytic. 1:28 Could you explain how you came up with the idea of the posio institute and what it actually entails? 1:34 Sure. 1:34 You know, I went through functional medicine training like everybody else. 1:38 What I found was that If you just treat everybody a la carte, they're kind of running the show, you know, when they are going to show up, 1:48 what they going do. 1:49 And it doesn't optimize people and you're not going reduce what's called single points of failure. 1:54 At least engineers talk about that in aerospace. 1:57 So I wanted to use aerospace algorithms because engineers that use Aerospace Maintenance Engineering algorithms, They reduce single point of failures drastically. 2:08 They improve optimization, they improve longevity, efficiency, all across the board. 2:14 And so you follow algorithms. 2:16 So I want to use those same algorithms and I wanted to change them for human biology. 2:23 And the other thing I wanted to do is I want to talk to patients or prospective patients before they joined up and see did they have radical willingness
Poszio Institute and Medical Maintenance Engineering 2:33 to change their lifestyle, to take their medicines, communicate with us, show up regularly at regularly scheduled intervals, 2:40 just like your plane, if you own a plane or whatever. 2:43 That plane has to go through regularly scheduled maintenance and checks, and even the pilot has do stuff before they take off, 2:50 all that kind of stuff. 2:51 So this engineering that happens in all of science everywhere doesn't happen in medicine. 2:57 So I created the Institute to run off of these algorithms. 3:02 And, you know, what we get out of it is we. 3:04 Robust changes and their physiology. 3:07 That's great. 3:08 You find things. 3:10 We find it early. 3:10 If we find cancer, we'd find early, so if we can find these early we're going to do, We can deal with it. 3:15 I love that. 3:16 They're very, very cool. 3:17 And again, I think it's a systemic approach is formulary because again like we were talking earlier, one of my favorite terms are homo sapiens sapience, 3:25 you know, like, yeah, it is the same thing. 3:27 Like you're one model. 3:29 In aerospace, they got to deal with a million different models. 3:31 You're a one-model. 3:32 Everyone thinks that they're so different. 3:34 I have this gene, or I had that gene. 3:36 They are like 99.9% the Same. 3:39 It's like I'll deal what the small differences are. 3:42 Same instruction manual with minor differences, right? 3:45 Yeah. 3:45 And the other thing that I found with functional medicine that didn't like is everybody's getting a la carte and they're getting nickel and dined. 3:54 Oh, I want you to do this bottle of this supplement and that bottle, that supplement, and this and, this, right? 3:59 And then all of a sudden they were like, Oh I didn' know I was going to spend this money. 4:04 But we tell them upfront, it's going t cost this much money for the year. 4:08 Everything's included. 4:10 Right. 4:10 And even with their supplements and their medications, we package all of them for them to make it super easy. 4:17 They're given at different times of the day. 4:19 We're going to be rolling out later this year software that they just take their pack and they run over your phone. 4:26 That goes right into our data lake. 4:29 I love that. 4:29 You know, we have compliance data and a lot of physicians are giving out supplements. 4:33 They have no idea if people are compliant. 4:35 People lie. 4:36 Why they lie, I don't know. 4:38 Especially to themselves. 4:40 But like, you know you run labs, like you're not taking fish oil. 4:45 Very true. 4:46 Right? 4:46 But now like we know exactly like what are people doing? 4:50 And it just makes it easier. 4:51 We want to make things as easy as possible. 4:54 Yeah. 4:54 And again, like, especially with the technology of AI, you have all kinds of different computer softwares, this, that, and the other. 4:59 I mean, patients and doctors are becoming more technology aware of what health is. 5:03 It's like a wild west is slowly getting smaller and smaller, which I think is fascinating and scary at the same time. 5:10 You know? 5:10 It really is, I love that patients use AI. 5:14 But you know, we have our own AI that we've trained here. 5:19 And I'll be like, look, it's how you prompt your AI and what data sets it using. 5:25 So it was like you said to your, AI blah, blah blah. 5:29 But when I put it in, like what happens is different. 5:33 It's because the data that we've put in and we have it accessing all of the that would ever run from the beginning of a clinic. 5:41 Right. 5:42 And all the studies that we've looked at and all of our algorithms that We've done for medical maintenance engineering. 5:48 and so I want you to look into things and I wanted to kind of own your stuff, but at the same time, I actually kind Of believe what we're doing and you know, 5:55 understand it and be a member of the Institute and study this things that were giving you and then, you Know, go ahead and, 6:01 and play with your AI and stuff like that, But I'd rather you focus on doing the things That we are telling you. 6:07 Right? 6:07 For sure. 6:08 For Sure. 6:11 Yeah, no, I couldn't agree with you more than that again. 6:14 It's unique how how it's like evolving every day, you know, of course, there's this AI, then there is that AI. 6:20 This influencer said this, this doctor said, it just it is getting so convoluted of points. 6:24 Is it like, we need common sense medicine. 6:26 And I think what you're doing is breaking it down to the straightforward form, formulary. 6:30 We are homo, homosapiens, I love that. 6:33 So kudos to you on that one, you know. 6:35 And now, let's segue, go to left field out of right. 6:39 Let's talk about senolytics. 6:41 I thing senlytic is probably one of the most overlooked things right now in regenerative, functional, whatever you want to call it, 6:47 all these industries right know, so can you give us a brief overview of what senulytcs are and kind of, the idea of why treating them is so important? 6:57 So you need synthetic cells when you're being developed. 7:05 They're good for healing and for creating things like say like you're making a heart, right? 7:10 So you got a ball of cells, but you gotta make all these chambers. 7:13 And senolytic cells help kind of regulate, you know, what cells die so that things can fold over and do that kind stuff. 7:18 They are really great for wound healing. 7:20 Um, they're also really good. 7:22 For preventing cancer in certain circumstances, Right? 7:24 so you can't just get rid of senlytic cell. 7:27 they have a certain need. 7:29 The problem is that the older you get, the higher the population of these cells become. 7:34 Right. 7:34 So, you know, kind of like, uh, an overview would be like these are cells that don't want to die. 7:40 They don' to go away. 7:42 Right? 7:43 They're not playing ball, so they're n communicating with the cells tha are next to them. 7:47 You know? 7:47 So they'r saying, I don t want talk to you anymore.
Senolytics and Fasting Mimicking Diets 7:51 And they're secreting all kinds of things. 7:53 We call it the SASP, the Sinolytic Associated Secretory Thenotype. 7:58 And this is a bunch of like interleukins, you know, and cytokines, some enzymes and some other signaling proteins. 8:06 These are really damaging. 8:07 So they can interfere with the cells that heal you. 8:12 Microglia, astrocytes, you know, even parts of your immune system that it's like dealing with like joints and stuff like that. 8:20 Any metabolic tissue like liver, kidney, heart, brain, they really tend to disrupt that a lot. 8:27 And so we don't want them to proliferate. 8:30 A lot of this proliferation, the reason that they can stay alive is that, that are messing around with the mitochondria's ability to go through apoptosis. 8:38 through cytokine C, right? 8:41 And by doing that, then the mitochondria are having a hard time treating this cell off. 8:46 So we want to like, turn them down, make sure that they're not growing enough. 8:51 And then we have all of these protocols that we're using to target them. 8:56 In the near future, we'll be able to use some really great targeted drugs. 9:01 It's just right now, the drugs that were looking at in the future are these BCL2 family inhibitors, which we found from lymphomas. 9:08 But the problem with those drugs is there's some nasty side effects. 9:12 Yeah. 9:12 Right. 9:13 Thrombocytopenia, all kinds of other stuff, you know, general lysis syndrome, it's all over the place, right? 9:18 But we do have some really good targeted ways of dealing with them. 9:23 Fasting works amazing, because that turns on autophagy. 9:27 Could you expand on that just a bit more? 9:30 Because I know I get that question in my clinic all the time. 9:32 Well, is fasting going to do, this is a new thing for when it comes to synthetic cells. 9:36 So I'd love for you to kind of touch on how fasting can actually help your body reabsorb these cells? 9:42 Sure. 9:43 So when you're in a really well-fed state, you are churning out the molecular target of rapamycin. 9:50 Right? 9:51 So if you want to do some bodybuilding or something, that's great. 9:54 But the problem about that is that when turn up mTOR, You turn down autophagy. 10:01 so it means that all the senolytic cells can grow, pre-cancerous cells grow and your body's not doing anything about it. 10:09 Right? 10:10 So we want to do intermittent fasting. 10:13 So like, I love Prolon, you know, it's the fasting mimicking diet because we can do it like every quarter. 10:20 Right. 10:20 And you can, by doing that, we lower mTOR and turn up autophagy. 10:25 and here at the clinic, like I have like a rotation schedule of like growth versus lean, or what we call it, build versus the lean cycle. 10:35 Right. 10:35 And the lean cycle, we're on a low calorie diet. 10:41 We're also on low protein and low animal because animal proteins very high in methionine and Lucy, which Jack's mTOR. 10:52 Right. 10:52 Plant protein doesn't have those super high levels. 10:55 I mean, there are some things like tofu and stuff that have higher levels, but not like the animals. 11:00 So we kind of want to like lower that. 11:02 We also want put people on a low protein diet. 11:04 And I always tell people that like high protein, diet, short life, low-protein diet long life. 11:10 Right? 11:11 And it's all throughout the literature. 11:13 Right. 11:14 Um, and I don't know why all these other people are saying high protein. 11:18 It's crazy to me. 11:20 Uh, it doesn't really help you build muscle. 11:22 We know that more complex carbs help your build muscles. 11:25 So it's kind of like, um, you have to build a house and you need to say a hundred bricks to bill the house. 11:30 Bring 200. That's not going to help. 11:31 Now you got to deal with all those extra bricks. 11:33 Those extra bricks. 11:35 And so, you know, those extra Bricks and for you, You're going to make sugar in your liver. 11:39 You know you're gonna do all kinds of nasty, stuff. 11:42 Increase all this nitrogen in you body that you don't know what to do with. 11:46 It's going affect your kidneys and most of all, it's just going raise them to one. 11:50 Right? 11:51 So lower protein diet, especially during lean cycle, we end lean psycho with a fasting mimicking diet. 11:57 Now we do a little bit of build. 11:58 So we go up on the calories a bit. 12:00 We get people that like build up their muscles. 12:03 Right. 12:03 And then we repeat and by doing that, We can target a senolytic cells. 12:09 so at the, at, the middle of a lean psych or like that at end of the lean, cycle end to eight weeks, you do that fascinating. 12:18 During that time, that's when we hit them with a bunch of Centilix. 12:23 So Quercetin. 12:25 Meat, potatoes of this one. 12:26 Here we go. 12:27 Quersetin, Fizzetin Tethia Flavans and Desapnib. 12:32 Yep. 12:32 Desanib is great. 12:33 I love that combo. 12:34 So that's our little cocktail. 12:36 And we usually give that near the end of the fasting because about three days into a fasting mimicking diet or a water fast, 12:43 I just don't like water fasting anymore because Walter Longo kind of showed us that, you know, a five day water, fast. 12:49 You're going to lose a little bit of muscle and you're actually going have a bit more inflammation than you would if you do fasting. 12:57 Okay. 12:57 So, um, and get all the benefits of fasting, mimicing, And I'll tell you what my compliance went up dramatically. 13:05 I had like two or three people doing water fasts for five days. 13:09 I have like a hundred people. 13:13 Could you explain the main difference between the two for people who don't really know what a waterfast is versus the other one? 13:18 Sure. 13:18 So a WaterFast is basically, this is what you get for 5 days, right? 13:27 You know, and how about it? 13:28 And, you know I did it for many, many years. 13:31 Right. 13:32 And I used to do like a lot of fasting. 13:34 I had to a five day water fast every three months and every month in between, I would do a three day. 13:41 Okay. 13:42 Just found it was a little bit too much. 13:45 Now just in the fasting mimic gang, this came out of $50 million worth of research at Walter Lamos. 13:53 So they got a grant from the government. 13:58 You know, and they looked at all these different foods that could mimic this state of fasting. 14:06 And you get it, you know. 14:08 I don't know five to 600 calories a day. 14:11 Right. 14:12 Sometimes a little bit like day three. 14:13 It's a pretty much lower than that. 14:15 And it's all like soups and you know, some of these little bars and stuff like that, and, uh, you get some, a glycerin to help, 14:22 help with the muscles and. 14:25 You get a breakfast, little lunch, dinner, snack every day. 14:30 Right. 14:30 You get some olives and it's pretty tasty. 14:33 Um, and now all their soups are liquid. 14:35 And so you get five boxes, you know, day one, two, three, four, five, And you just follow it and you feel great at the end. 14:43 Inflammatory markers drop. 14:46 Average person loses like, I don't know like eight pounds. 14:48 Now you think like oh my God, that's terrible. 14:51 It's not, it is water. 14:52 Right? 14:52 Because you go through glycogen depletion. 14:56 And so all the glycogen after a couple of days has gone out of your muscles. 15:00 Well, what goes with the Glycogene is water. 15:03 That's why it's a carbohydrate. 15:04 Right. 15:05 And it just water loss. 15:07 But the average person loses almost a pound of visceral fat by the end of the fasting. 15:13 Okay. 15:15 To me, that's like profound. 15:17 Right. 15:18 So three days into this diet, your body's kicked in and autophagy is running strong. 15:25 And so your bodies already going after these bad cells instead of, I'm going to get these senolytic cells. 15:29 I mean, we'll get this pre-cancer cells and then you hit with all the senoliths. 15:34 and so we get at this really profound effect out of body. 15:38 Right after that is when we go into build cycle because we cleaned out all of the bad. 15:43 so let's build up the good. 15:45 And then we just repeat, rinse and repeat. 15:48 Rinse and Repeat. 15:49 Now, is there a way that you might clear too much at a specific amount of time so there's too many cells that are leaving the system that can overload 15:56 you or is that almost impossible? 15:58 I think you can only do that with really powerful drugs. 16:03 I've never seen it. 16:06 It's theoretical. 16:07 i think it's more theoretical if we start using these BCL2 inhibitors. 16:10 That's a real possibility. 16:16 There's people on to satin like a hundred milligrams a day for like years and years. 16:21 Yeah. 16:21 We're just using it a couple of times every quarter. 16:24 So it's not, it, not anything that's going to really cause. 16:27 Have you ever done it done the research on the Fox Oh four DRI or no. 16:30 Right. 16:32 I haven't played with it. 16:33 It's gonna be great. 16:34 You know, once we can dial it in, you know we're indirectly affecting Fox. 16:42 Oh, through the whole program. 16:45 Perfect. 16:45 And again, like, you know, I think the Santhinib and then in Corset and like we, we do a lot of the, uh, the Courset in IVs here, 16:50 which again are kind of focused on that. 16:52 I it's, it is fantastic. 16:53 The way it works plus everything else it does, minus the actual synthetic actions of it. 16:57 There's so much more that it can do as well. 16:59 Sure. 17:00 Right. 17:01 Um, and try to rotate lots of different things. 17:07 Cause there's always these feedback mechanisms. 17:10 Right. 17:10 And your body's always trying to find homeostasis, even though it can never, it's not, not theoretically possible to get home, 17:15 you know, stasis that like, your bodies always moving towards that. 17:18 Right? 17:18 And so if you hit something for too long, Your body is going to regulate. 17:23 So I love to pulse things on and pulse, things off, pulse on, pull things.
Mitochondrial Health and Performance Testing 17:28 You know, it's the same thing with like, you know. 17:30 Low calorie, a little bit more calories, right? 17:34 You don't have your lifting, lighter lifting more like calisthenics and that kind of stuff. 17:39 And your body responds really well to that. 17:41 Yeah, exactly. 17:42 So when it comes to the actual senolytics, can you explain how they focus on the actually cell itself and not healthy cells? 17:49 Yeah. 17:51 The senlytic cells are turning off that mechanism where they don' want to die. 17:58 Regular cells aren't doing that, right? 18:00 They're not turning off with that cytochrome C, so that's all working. 18:03 So when you're working with senolytics, they're targeting that mechanism of action in the mitochondria. 18:12 And the other cells are already fine, you are not going to target them. 18:17 We like to use metformin too, because metormin is more of a centimorphic. 18:23 The difference is, a senlytic is something that is going go kill those cells directly. 18:28 And a centimorphic is something that's going to kind of mitigate the issues of the release of all those compounds from that cell. 18:35 Exactly where I was going. 18:37 Now, did you focus on anything like mitochondrial enhancement while you were doing this? 18:41 I mean, just for disclaimer, I'm on the advisory board for, um, Versailles and, uh, versaille is the me screen test. 18:51 So Dr. 18:52 Hemal Patel created the me screen tests from a grant from NASA. 18:57 Cause before that you had to do a huge needle biopsy of your quad. 19:01 You know, that's not comfortable and a really sophisticated lab can only do like two of those tests a day. 19:08 So he was able to take serum and use serum. 19:13 And. 19:15 He was basically finding, you can talk to him more about this, but basically if you take a standard kind of mitochondria and you put it in your serum, 19:24 it'll function like you. 19:27 And so they found that by this assay that they came up with is about in 95 to 98% is accurate as a muscle biopsy. 19:37 So it can tell me like how accurate, like, how much energy can your mitochondria make? 19:42 How do they work under stress? 19:43 What kind of reactive oxygen species are being made? 19:46 Right. 19:46 How did they were out of those happen under your stress. 19:49 And so there's all these different categories that you can look at. 19:52 So I do that test here every quarter. 19:55 Because I think that mitochondrial health is at the pinnacle of one of the things that we really need to be looking at. 20:02 And if you miss it, it's terrible because I've seen it where like, you look at your like functional medicine labs, right? 20:09 You look all your inflammatory and your lipids and all this kind of stuff. 20:12 This person looks great. 20:13 Then you run their mitochondria and it is horrendous. 20:18 And so, you know, we come up with mitochondrial stacks and, there's all the lifestyle stuff you want to be doing. 20:24 Like you wanna be going your cold plunges and your saunas and you'll want make sure you do explosive work. 20:29 The one thing that I really have a hard time getting people to do. 20:32 And then once they do it, they get addicted to it is sprinting. 20:36 You know, when you get older, I would love for people to do a hundred yard dashes, but they pull hamstrings, right? 20:42 Cause they haven't been doing it. 20:45 Cool in the hammies, man. 20:46 Heck yeah. 20:47 And then you're screwed, Right? 20:49 So I have them sprint on a bike, or like on, on skier, because it's really, really hard to pull muscle on bike. 20:59 And so, but I want this like really high end output because you have about two to three seconds ATP, you know, about four to five seconds to create team phosphate. 21:11 If you're not at like a hundred percent output, You don't even tap into that. 21:16 Right? 21:16 Your body's just using glycogen. 21:18 Right. 21:19 And the mitochondria are like, whatever. 21:21 But when you're at a hundred percent output and you deplete the ATP and the creatine phosphate, mitochondrial freak out. 21:28 That's the stress that you need, the hermetic stress for them to divide and to become larger and more efficient. 21:37 I try to get people to do sprinting at least twice a week. 21:41 Then I also want them do deadlifts. 21:46 Right. 21:46 I'm just really good for him and, you know, bracing the core, the whole kind of thing. 21:51 And then mitochondrial stocks, kind like, um, PQQ, CoQ10, carnitine, taurine. 22:00 You know? 22:00 Like there's a bunch of stuff. 22:02 The most important thing is working on keviolin. 22:05 So the mitochondrial, they need certain fatty acids and the, mitochondria are just not sitting there talking to each other through quorum sensing. 22:14 They're talking directly to the cell membrane and they're also talking, directly, to nuclear membrane. 22:22 So they are kind of coordinating everything. 22:24 But if they don't have the right fatty acid for the cells membranes and for, in caviolan, it can't communicate. 22:32 And so, you know, we also make sure that they have enough like phosphatylcholine and phosphatylserine, right? 22:37 And, so that you can build these things up. 22:40 And that's all in those supplement packs. 22:42 We also tell them what dietary sources are good for that. 22:46 It's really awesome because once you start doing all this stuff, You notice that meter go way up and their mitochondrial score goes super high. 22:54 Now I know. 22:54 Okay. 22:55 You're doing well. 22:56 From an engineering perspective, I have a lot of engineering friends. 23:00 I probably would have been an engineer if I didn't become a doctor. 23:03 Um, there's a saying, it's like, give me enough energy and I can fix anything. 23:08 Very true. 23:08 And again, you kind of have to do these in tandem in a way. 23:13 You know what I mean? 23:13 And so your mitochondria making all your energy. 23:16 and so if your Mitochondria aren't functioning well, think about it like a factory, like okay, if all of a sudden I, have one third of the amount of energy 23:24 that I need, I'm going to have, to shut certain machines down. 23:28 Right? 23:29 And they were going to have to like, make it warmer because it can't run the air conditioning now. 23:32 And now, you know, and I can afford to, have these other people working. 23:35 You know this is a big problem because the older you get, the more damage is happening. 23:42 Right. 23:42 So you actually need more energy. 23:44 The older, but the old, do you, get the less energy you have available? 23:49 So it's one of the reasons that the oldest you'd get to faster, You get old. 23:55 What a conundrum. 23:59 Are you are you dabbing anything like when it comes to the actual mitochondria things like MOTC human in SS 31? Yeah, so I've done a bunch of these to 24:08 use a lot of those peptides even before like the FDA shut everything down. 24:13 And they're mild. 24:15 I wish that they were robust. 24:17 I really do wish they robust the supplements and the lifestyle Trump them so strongly. 24:23 They're just such a mild change, but they get touted. 24:27 Like they're massive because of the propaganda behind peptides. 24:32 Um, and not that I use peptide all the time. 24:34 Right. 24:35 But like, I've never seen them move a me screen that much at all. 24:40 Nothing trumps lifestyle. 24:42 I mean, like you said, I think you nailed it. 24:44 Sprints, deadlifts, things like that, getting good sleep, all that kind of stuff tramps any peptide hormone on the market. 24:50 Yeah. 24:50 And you know, i'm a big proponent of sauna because of the, you when you're in a sauna and you release heat shock proteins, 24:59 You can enhance how you fold protein. 25:03 The older we get, the worse protein folding happens. 25:07 So the ribosomes, they'll go make the protein, but then the folding gets all messed up. 25:13 But if you have enough heat shock proteins, your folding becomes really good. 25:17 You got to be in the sauna a lot. 25:19 I used to just say, okay, get in a sauna like three times a week, and now we have more data. 25:22 If you're in it seven times, it gets even better. 25:25 Wow. 25:25 So it's up to seven now. 25:26 I heard five was the gold standard. 25:28 Yeah. 25:29 It's like, you know, I'm just like. 25:30 You know now I try to get everyone to, get a really good quality infrared sauna. 25:35 with high tech house out of Boulder. 25:37 Cause I really like their emitters and you, know it low EMF and non-offgassing wood and all that kind of stuff. 25:44 But the reason I like infrared over regular sauna is the amount of time spent. 25:50 So if you swallow a thermo, like they had these little swallowable thermometers, so they can look at your core body temperature and you put somebody in 26:01 a good infrared and then you'd put someone in like say 190 degree regular sauna, right? 26:06 Eventually they'll both get to the same, you know, core, body, temperature, but the infrared gets there faster. 26:13 Faster. 26:13 Okay. 26:14 Right. 26:14 If you stay in the hot sauna you'll get higher. 26:17 It'll even get hotter. 26:19 But you don't need it. 26:21 Right. 26:21 Cause really all you want to do is detox and raise your heat shock proteins. 26:25 And we know if you're in too hot of heat, it's an extra stress. 26:29 So then you go in the opposite direction. 26:31 It's like, what's the right amount of stress? 26:35 What about steam rooms? 26:37 It doesn't raise temperature fast enough. 26:40 Okay. 26:40 Yeah. 26:42 But the infrared sauna, cause it cooks you on the inside. 26:45 You go to dinner somewhere where it is cold and they have the heater above you. 26:49 Right? 26:50 And you're instantly warm. 26:52 Right. 26:53 Cause you getting cooked. 26:54 So, uh, you know, I'll get in the sauna and I'm just stick my back right up against the emitter. 26:59 And, within a couple of minutes of sweating and you get into the regular sauna kind of takes a little longer. 27:04 right? 27:05 So it's like, it can get the same benefit, but like I noticed that like 25 minutes in my sauna is enough. 27:12 and the data from the infrared is about like 140 or above for 20 minutes. 27:18 And I just say, once you start sweating, that's when you can start the timer. 27:23 Oh, okay. 27:24 I like that, actually. 27:25 That's super good. 27:26 Now, when it comes to the whole mitochondria stimulation and the holistic therapy aspects, are there any dangers that somebody should watch out for? 27:33 Yeah. 27:34 You know, I wouldn't take quercetin and fisitin all the time. 27:38 It needs to be pulsed. 27:40 What's a good pulse schedule, would you say? 27:43 I would say for the average person, you know, one of the safest things that can do, and I know I'm throwing out a whole bunch of names here,
Lifestyle Tools, Supplements, and Sauna Protocols 27:49 but we're not doing CNN. 27:51 Do it. 27:52 I love the life extension product called Centilitikette. 27:56 Okay. 27:57 Um, there's a lot of data behind it because a lots of Querstin and Fizitin is not well absorbed and it needs to be in a formula that's been tested to have 28:06 high absorption. 28:07 Uh, the other reason you'll know whether or not it's working or is you don't have a loose stool. 28:12 You know, cause some of those cells will die and, you know. 28:15 I think that's kind of a good measure of whether or not you're getting it. 28:18 And so three capsules of that once a week is good. 28:23 and then, we do that for most of the time, but then we even take some time off of. 28:29 Well, like we're doing built. 28:31 Okay. 28:32 Right. 28:32 And so I think that's plenty. 28:34 You know, I'd think anything beyond that is more like if you had chronic inflammation and you didn't take extra quercetin or something like for that, 28:41 until you figured out like, where's the inflammation coming from? 28:44 Like what foods is causing this problem? 28:46 Or, you know is my stress too high? 28:48 Am I not in cold hearings? 28:49 I'm not sleeping well enough. 28:51 So you can figure that out. 28:52 I mean, it's fine to do some quersetin, but like the higher querson is like that it is a band-aid approach. 28:58 And it's great. 28:59 Sometimes you need a band-aid approach, but let's get rid of the band aid approach and get you more optimized. 29:05 Is there a way you can measure the amount of senescent cells you clear at the moment or not? 29:10 There's a test, there's bunch of different ones, right? 29:14 And, you know, There is like the top 10 SASP, Right? 29:19 IL-1, IL6, TNF-alpha, tissue growth factor beta. 29:25 You know there is a bunch that we measure. 29:27 There a lab that use, it's Cytodx. 29:32 and it has like pro-inflammatory and anti-flammatory cytokines. 29:36 So it gives me an idea of how well we're affecting the SASP. 29:42 We get that on the patients that are on this program. 29:47 It's a little expensive, but there's lot of clinicians following this and you have to have dry ice in your clinic. 29:54 which is dry ice for you know, you just have to make sure that it arrives frozen. 30:00 So you can do it without dry eyes. 30:03 You just, get two really great thick ice packs and just sandwich them and rubber band that thing and send it and hope for the best. 30:15 But it usually does work. 30:18 Okay, cool. 30:18 Cool. 30:18 Yeah, guys, I was curious. 30:19 I think diagnostic testing is the paramount for everything. 30:24 So when somebody comes to your clinic, are you testing for natural killer cells and different types of autoimmune issues or anything like that to kind 30:31 of set them up for the actual treatment? 30:33 Yeah. 30:34 We look at it sometimes. 30:35 And I just like using inexpensive testing through that because sometimes you have to go down the rabbit hole and those are really expensive tests. 30:43 But if you get true age, um, and you know, Ryan Smith set the set that up, right. 30:50 They test for a lot of this stuff and it's not direct testing, but it it, it good enough. 30:56 Right. 30:56 And I think that like. 30:58 If you're looking at like neutrophil lymphocytes ratios and neutrophyl, like, uh, monocyte ratios, you just reading your test, 31:06 your normal test pretty well. 31:07 You can kind of see if there's something. 31:08 Yeah. 31:10 And if you start seeing that senescence that's, then you can start that immune senesis, and then he can go down to rabbit hole and order a bunch of stuff. 31:18 But you'll see immune senescence in your normal labs and in, you know, what I call the age-adversal labs, right, your epigenetic biological tests, 31:26 like your glycogen age, make sure you're checking your Glycans, that cytodx look at your SASP, you know, and if that stuff's on point, 31:35 like your natural killer cells. 31:37 It's good enough there. 31:38 Yeah. 31:38 You know? 31:39 Like unless he had some weird genetic thing, but we also do shotgun genetics and everyone that comes in. 31:46 So full genome, just so we can look for all the weird stuff, it happens once in a while or somebody's got something that, 31:53 is really going to cause a problem. 31:55 And then we just try to come up with a plan for that. 31:58 Right? 31:58 Just to decrease that or, you know, try to mitigate that as best we can. 32:02 No, I think it's great. 32:03 Like, especially if you see certain things like, extremely chronic reactivated EDV, CMVs, someone with mold toxicities, all these different things, 32:10 they're going to have ass all day. 32:12 You know what I mean? 32:12 Like such a situation, like no matter what, You're gonna want to take them down that whole, senescent cell clearance aspect of it too. 32:19 So like you said, kind of make those associations. 32:23 Yeah, it's great. 32:23 You can measure MMPs, right? 32:27 Like MNP9 and MnP3 and stuff like that. 32:31 That's part of the site of DX, I think. 32:33 I I don't know. 32:37 You know, I just think the protocols work great. 32:40 Yeah, for sure. 32:41 It's just getting them to do it. 32:43 We all know we have them. 32:44 So you might as well clear a little bit of it, you know? 32:46 The older you are, shit, man. 32:47 Keep going with it! 32:49 That's why, we always like, that's how I do the interview, right? 32:51 Do you have radical willingness to this? 32:53 Because it's not easy. 32:55 I can't just give you a simple pill. 32:57 No, for sure. 32:58 Maybe one day it'll be Star Trek medicine and I can retire. 33:02 We still have a couple of these. 33:06 I'm actually coming to the end here. 33:09 Always like to ask everybody who's on here two questions for it. 33:11 And again, one's a unique one, and one is a basic one. 33:14 So the first one if you're a physician who is looking to get into something like this, or actually you'll come to your institute, 33:20 And you're coming out of the whole traditional medicine box. 33:22 What are some things you want to look at when it comes to jumping into this industry? 33:25 Like, you know, what are good places to learn or some good ideologies to take into building a practice? 33:30 I think right now a good place to learning is either Institute for Functional Medicine. 33:36 or American Academy of Anti-Aging Medicine. 33:39 I think those two have really good, well vetted programs to like get an overview of things. 33:45 The issue I have with those is they regurgitate all this information to you and they don't tell you what to do. 33:52 It's like, wow, go out and figure it out. 33:55 Yeah. 33:55 And so the project that I had going on right now is called the Institute for Medical Maintenance Engineering, IMME. 34:02 They can go on the website and look at IMMe. 34:05 And within a year from now, we're going to have a physician training. 34:10 So we'll going train physicians to be medical maintenance engineers. 34:13 And we are also going be giving them everything that they need. 34:17 Say I'm a Physician and I want to start something now. 34:20 I have to a business owner and then I'll have supplement stock and connect with all these pharmacies and it's a big pain. 34:28 What we will do is give them all the algorithms that I've built out. 34:32 and we're going to give them all the software so their patients have the app and all that kind of stuff. 34:36 And then all they do is they just sell out a sheet, basically like what supplements does this person get, what medicines does the person gets, 34:44 and then what hormones do they get and everything's fulfilled for them.
Training Physicians and Choosing the Right Clinic 34:48 I love that. 34:48 And all that other training we just give them. 34:50 It's the future. 34:52 That's going to happen soon. 34:52 The consolidation of knowledge, which I think is good because right now, like I always tell people, we're in the middle of the wild, 34:58 wild west and one of biggest markets on earth right. 35:00 Now there's so much miss and disinformation. 35:02 it's bananas. 35:03 You have people who aren't even physicians dictating like law here. 35:06 I mean, if I hear one more influencer tell me about a peptide, I'm going go crazy here, so I don't want that angle. 35:14 Yeah. 35:15 So, and we have, I've got about 12 people on the scientific advisory board. 35:20 Uh, Hemel Patel's on there. 35:21 We even, Aubrey DeGray is on. 35:22 Yeah, so we got some really great, uh, people. 35:26 It's a horsewood on that. 35:28 Most people know she's out there, you know, it's not just like, Oh, what does Alex say? 35:34 You know? 35:35 So this is all vetted out, you know, and we have it. 35:38 We have the algorithms, getting looked at by everyone, scientific community, at least people are, tenured physicians are there, 35:47 PhDs with tons of work. 35:49 So it's been looked up by a lot of people. 35:51 we had a huge data lake, we haven't AI on top of that data Lake and everything's integrated. 35:57 I just think that, physician coming through the program, they're going to be like, Oh, wow. 36:02 You know, this is great. 36:04 And it's just not, you know somebody regurgitating something for functional medicine that's been regrogated for 20 years. 36:09 Exactly. 36:10 Oh yeah, You couldn't be more right on that one. 36:11 So the second question is, let's kind of flip the script. 36:14 If you're a patient, working to come into this industry from traditional medicine, what are you going to sit there and basically tell them like, 36:21 This is what you should be looking for in your doctor, in you clinic, or basically, if you want to figure out how to really conquer this, 36:26 market and your health, is this what should find in a functional medical doctor? 36:30 Yeah, I would say, you know, ask your doctor like, okay, and you go on chat and just ask Chad or Brock or something to give you a little list, 36:39 right? 36:39 And just say what are the top 10 ways that people die? 36:42 Right. 36:42 And you show how are you going to prevent these things from happening? 36:47 How are we going look to see if this is going happen to me in the next few years? 36:51 And they should be able to tell you, like, we're going to give you a clear heart test. 36:54 We're gonna do this full body MRI. 36:55 And we are going do RGCC test to look for, you know, circulating tumor cancer cells. 37:00 You know? 37:01 And if they don't have a quick answer, they're like alright, that's a problem. 37:05 How are you going optimize my hormones? 37:07 Right? 37:10 And nothing against the people that are using injectable testosterone, but the data on injectible testosterone versus the pellets, 37:18 as far as cardio protection is concerned, it's kind of lacking, right? 37:22 And the other thing is like, It's highly dependent on people doing what you tell them. 37:27 Hardest thing to do, hardest thing is difficult, right? 37:30 But like when you're placing a testosterone pellet, like one, you can give a fraction of the amount of testosterone over 13 weeks in a pellete and you 37:39 canned an injection. 37:41 Right? 37:41 So that's less metabolized testosterone, which is good. 37:45 We don't want a ton of metabolize testosterone. 37:47 We also don't want to inhibit the feedback loop between your brain and your testes as much, you know? 37:54 So if I can give you less testosterone in a pellet in greater outcome, that's great. 37:59 Now, and there's people doing like estrogen pellets and not so much against that, but like. 38:05 The problem with that is there's only E2 pellets. 38:07 There's not E3 pellet. 38:08 And so you can't do that E two to E three balance for cancer protection. 38:14 God forbid somebody gets breast cancer or something like that and you're not getting that pelleted out. 38:18 No, for sure. 38:19 That's what I'm saying. 38:19 If there is no going back on that one. 38:21 Right? 38:23 And the other thing is like, I give hormone cream. 38:26 So I'll do my estrogen. 38:27 I do E 2, E 3, and I will do progesterone and cream, And I have them put it on their face and neck. 38:34 And we have a Vizia analysis here, and within six months, their skin age drops dramatically. 38:42 And their collagen production goes up, when their elastin production does up and it's amazing. 38:46 If you have the estrogen pellet, it can happen. 38:49 True, very true. 38:50 on that one. 38:51 I like that. 38:52 Again, like, you know, I've really enjoyed talking to you today because not only do you have, what's going on, your helping to empower physicians, 38:58 which is great, it's gonna increase efficacy across the board, but at least you're given information that's actually usable and certifiable, 39:05 i guess you could say. 39:06 Which is what I liked. 39:07 So, for all the physicians and everybody listening here, where can they find more information about your institute and about kind of everything you've 39:13 got going Um, they can, um, I have a ton of lectures on YouTube and they go to our web. 39:20 They can go PazioInstitute.com and there's like a list of videos there. 39:23 Um I'm always speaking somewhere. 39:26 So that's great. 39:27 And there are tons of really good podcasts that I've done. 39:30 Uh, so they do that. 39:32 There's some, there is some information there, you can on the Institute for Medical Maintenance Engineering website. 39:37 What's that name? 39:38 IMMEglobal. 39:39 com right now. 39:41 They can check that out and I would say stay tuned for the IMME for, the trainings that's going to be coming up soon and you'll be, 39:49 they'll get a certification and then you have access to the data lake and all this stuff. 39:54 Right. 39:54 And it'll, be so much easier because you won't have to have all of this crap in your office. 39:59 You know? 40:01 You don't have to be, you know, to worry about inventory and all this other stuff, basic stuff you will, but it's nothing like you have do. 40:09 Setting up a functional medicine office sucks. 40:13 That it does, man. 40:14 I hear you man, your god's ears. 40:16 Holy cow. 40:18 Well, we're trying to make it easier for the patients and try and make easier. 40:21 For the doctors. 40:22 Yeah, exactly. 40:23 It's the whole thing. 40:23 And I think it needs to be easy for both. 40:25 I mean, I, think with what you're doing, AIs, when you do it correctly, formularies, and like you said, the homo sapien sapiens kind of have like an actual 40:34 structured aspect on how to treat everybody. 40:35 it's great. 40:36 This is what this industry needs. 40:39 One of the really great things that I'm thinking we'll be able to do really well is we are going to try to pair people that want to start a business and 40:46 physicians together. 40:47 Love it.
Closing Remarks and Access Labs Outro 40:48 Right. 40:48 And so it's just like, okay, these guys got the money and they're going to open up the box, right? 40:52 And we're gonna pair them with a physician and the physician's gonna vest over X amount of time. 40:57 Your salary is going go up and then they have a percentage of the, of, uh, clinic. 41:03 So now you tied them together and physician doesn't want to leave because he's vested or she's invested and you know, and, 41:10 it works all around. 41:11 and Then you, know that you're, going be treating people properly because you are in the program. 41:16 I think it's great, man, you got yourself a good former there, my man. 41:19 I gotta say. 41:20 You take a long time. 41:24 It's been a real delight, guys. 41:26 Check everything out. 41:26 I mean, like, I'm gonna go on there and obviously nerd out a little bit more. 41:30 Thank you so much, my man. 41:31 It was so good to have you. 41:32 Again, this is the Lifestyle Medicine Podcast. 41:34 We're powered by Access Medical Labs. 41:35 You can find us on YouTube, Spotify, pretty much anywhere podcasts are found, you can us. 41:40 And again, just stay tuned. 41:41 check him out, This is really, really good stuff. 41:44 Not only the analytic aspect of it, the mitochondrial, we, that was a fun surprise as well, as the Institute and everything else. 41:51 So my, man, thank you again. 41:53 My pleasure. 41:53 Take it easy. 41:54 Bye bye. 41:55 Thanks for joining us today on the Lifestyle Medicine Podcast. 41:59 At Access Labs, every innovation we pursue is driven by one bold purpose, making personalized medicine more practical and accessible for patients and providers. 42:09 If this episode sparked new ideas or challenged how you think about patient care, awesome. 42:14 Follow the show and share it with a colleague who's ready to level up their practice. 42:18 Head over to our website at accesslabs.com and register your practitioner account today. 42:24 You'll get access to over a thousand routine and advanced biomarkers. 42:29 with 24-hour results. 42:31 When signing up, select Lifestyle Medicine Podcast as how you heard about us and score 10% off your first invoice. 42:39 Oh, and don't forget, drop us a review. 42:42 It helps more practitioners like you find us. 42:46 We'll see you next time.
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