Full Transcript Summit Introduction and Guest Welcome 0:00 Hello and welcome back to the Future of Menopause Menopause Medicine Summit. 0:05 We changed the name this year. 0:06 This is our fifth year and I keep stumbling on. 0:09 The name used to be called Mastering the Menopause transition. 0:11 Now we're the future of menopause medicine. 0:14 And I think today's talk is like so right in line 0:18 with the future of menopause medicine. 0:21 And many of you probably already know doctor Dale, Bredesen, 0:25 he is just a pioneer. 0:29 He's a New York Times best selling author. 0:32 He created the breed and protocol, his work, 0:36 and how we think about Alzheimer's and cognitive function 0:40 has just transformed so many lives, so many clinicians lives, 0:45 who then can go use his work to help their own patients. 0:48 And so I just have there's so much good to say, but I want to get to the meat 0:53 and potatoes of what he's up to because there's some exciting stuff. 0:57 So I've been doing this 0:59 menopause summit for five years and you have been on my list. 1:02 And so I'm just so grateful that we finally were able 1:06 to synchronize schedules and have you come join us here on the summit. 1:10 So thank you so much for being here. 1:12 Thank you so much. 1:12 Doctor Steele's great to talk to you. Yes. 1:15 So let's just jump in. 1:18 You were starting to tell me that there's new stuff going on. 1:21 And for anyone who doesn't know who you are. 1:23 Why don't you just give a brief 1:25 introduction of your work and what you're doing and why? 1:30 Why was it so important for me to have you come and speak 1:34 about brain health and Alzheimer's on a menopause summit? 1:38 Yeah. Thank you. 1:39 So, yeah, I ran a lab for 30 years. 1:42 I'm a neurologist and neuroscientist by training, and we studied for 30 years. 1:47 What are the molecular fundamentals of neurodegeneration? 1:52 Why do you lose synapses? 1:53 Why do you lose neurons? 1:55 As you know, this has been the area of greatest biomedical therapeutic failure. 1:59 As people often say, everyone knows a cancer survivor. 2:03 No one knows an all timer survivor. 2:04 So whether it's Alzheimer's, frontotemporal dementia, Louis body 2:08 disease, cortical basal syndrome, progressive supranuclear palsy, ALS 2:13 just go right down the list. 2:14 These are all untreatable terminal illnesses, 2:18 and about 15% of the population dies of Alzheimer's. 2:22 So it dwarfs the pandemic about. 2:25 Oh, you know, 2:25 over 1 million people died, as you know, during the pandemic from Covid. 2:29 But we have of the currently living Americans, the statistics say 2:33 that about 45 million of us will die of Alzheimer's.
Bredesen's Neurodegeneration Framework 2:38 So it's it's a horrible situation. 2:40 And so way back in 2011, 2:44 we kind of came to the conclusion, after all this work with fruit flies 2:49 and transgenic mice and cells and all this, 2:52 that all timers have been kind of misunderstood. 2:56 The idea was that, oh, it's a misfolded protein. 2:59 It's reactive oxygen species, it's herpes. 3:02 You know, 3:02 there are dozens of theories 3:04 about what it is, but none of them has ever led to improvement. 3:07 What we saw is that you have this remarkable synaptic network. 3:12 You have about 500 trillion synapses in your brain, 3:17 and that this is really a network insufficiency. 3:20 You know what's happened as we've evolved over the years, 3:24 you know, from our ancestors, we always evolve 3:27 toward better performance at the expense of durability. 3:31 So we have these incredible brains so you can store more in your brain 3:37 than over 2000 home computers. 3:41 Imagine lining up 2000 homes, and you can store 3:44 more in your three and a half pound brain than to over 2000. 3:48 So it's incredible what humans can do. 3:50 Similarly, you know, there's a subnetwork that's for motor modulation. 3:54 That's the one that fails in Parkinson's. 3:57 There's one for power amplification. 3:59 That's the one that fails in ALS. 4:01 So you can see what what Alzheimer's really is is a network insufficiency okay. 4:07 So there's all these things that are on the supply side 4:10 including hormones of course trophic factors, 4:13 nutrients, oxygen, mitochondrial function, blood flows. 4:17 Go go through the list, dozens of things. 4:19 Then there are dozens of things on the demand side. 4:22 So if you've got inflammation, infections, 4:25 that increases the demand on that system. 4:27 So as soon as you start taking the supply to low and the demand too high. 4:33 What do you think happens? 4:34 You now back down on the number. 4:37 And if you don't understand that and you don't look for the right things, 4:41 you just keep doing that. 4:42 And so people end up with dementia and death. 4:45 So we started saying, okay, if that's the case, 4:48 could we simply evaluate all these things, increase the various supply pieces, 4:54 decrease the various demand pieces, and actually turn things around. 4:59 And so I saw Patient Zero very first one after we had been turned down for a trial. 5:04 Because this was too complicated. 5:06 It was more of a precision medicine or functional medicine sort of approach. 5:11 And of course the earbuds always say, we want you to do one thing. 5:14 Well, this is not a one thing disease. 5:16 This is a network. 5:18 And you don't you don't deal with a network with a hammer. 5:20 You deal with it tweaking, tweaking here and there and here and there. 5:23 So Patient Zero came to see me in April of 2012. 5:28 I was shocked when she got much, much better as she said 5:31 her memory improved was better than it had been in 20 years. 5:35 She was 67 at the time. 5:37 She's now 82 and she's because she was just ready to turn 68 when I saw her. 5:41 She's 82. 5:42 She is doing great. 5:44 She just walked across the United States from the Pacific Ocean 5:48 to the Atlantic Ocean. 5:49 You can see this if you go to Judy Walks and amazing. 5:53 And she is now going to walk across England next month. 5:57 Oh my God. 5:58 So yeah, she's she's amazing. 5:59 And so we've now had thousands of people come through this. 6:03 And this is a precision medicine type of approach. 6:06 So you have to look at 6:07 and the big ones as you know, are anything that creates inflammation, 6:11 any sort of systemic infection, poor oral microbiome, chronic sinusitis, 6:17 leaky gut, tick borne illness, any of those sorts of things. 6:21 Metabolic syndrome is a big one. 6:23 And then the second one is anything that creates toxicity. 6:26 So then that's the three is, you know, inorganic organics and bio toxins. 6:30 And then the third one is reduction in energetics. 6:34 So poor blood flow, poor oxygenation sleep apnea a very common contributor. 6:39 So we determine all of these and then we address what is there. 6:44 So it's personalized. 6:46 And we've now had done three trials all of them extremely successful. 6:50 You can read. 6:51 The first two are already peer reviewed and published and online. 6:55 The third one we just posted the preprint. 6:57 And actually the third one we compared the outcomes. 6:59 This is a randomized controlled trial. 7:01 The first two were proof of concept and the. 7:04 We compare this to other trials looking at Cohen's d which is an effect size. 7:09 So it's what's the effect size of the interaction. 7:11 And the thing that came in second, 7:14 we were 90 above that and everything else was lower than that. 7:18 So it was by far the biggest impact on cognitive decline. 7:23 And we did the same thing as other trials. 7:26 These were people 7:26 who had MCI and early dementia, which is kind of the standard now. 7:30 So to be fair, we didn't take people who were in end stage dementia. 7:34 And we encourage people, please come in early. 7:38 We recommend everyone who's over 35 get evaluated. 7:43 And look, if you're 65 and you're doing great. 7:45 Don't wait. 7:46 Get evaluated. 7:47 I'm now 74. So I just had my blood test. 7:51 I just had you've got now biomarkers that weren't available 7:54 even a couple of years ago. 7:55 So you can check your towel. 7:57 217 your AP, your NFL. 8:00 And you can see it's just like a hemoglobin A1. See. 8:03 But it's for your brain instead of for diabetes. 8:05 So this is a new era share. 8:07 And this is something we've never been able to be done before. 8:10 We don't have to wait for this to catch up with us. 8:13 And of course, Bart is a huge player. 8:17 And if you've got a moment, I'd like to tell you 8:19 about one specific syndrome that is very closely related to 8:26 yes, please, please, I'm all ears. 8:28 The one thing that we saw in actually published 8:31 this several years ago, we started seeing people. 8:35 These are almost all women, and they're all from the late 40s 8:39 to the late 50s, typically around the time 8:42 of perimenopause, menopause or shortly after menopause. 8:46 And they were showing up with a syndrome. 8:49 They ended up having Alzheimer's. 8:51 But the syndrome was atypical for Alzheimer's. 8:54 Often it would start with depression and so they would be treated for depression. 8:58 They say, oh, you just have depression. 8:59 And then they would say, wait a minute, 9:00 this person, they're having trouble with their cognition.
Menopause, Alzheimer's Risk, and Inhalational Causes 9:04 They often would present with a non mystic 9:08 about two thirds of people with Alzheimer's present with memory loss, 9:12 but about one third will present with executive function or prosopagnosia 9:16 problems. 9:16 Recognizing faces or problems, word finding, navigation, things like that. 9:23 And so many of these people were coming in with problems with executive function. 9:28 They couldn't plan, 9:29 they would lose their jobs because they couldn't plan things anymore. 9:32 And so when they started evaluating, they said, hey, what is going on here? 9:36 They end up with Alzheimer biomarkers, Alzheimer Pet scans. 9:40 So these people do have Alzheimer's, but is an atypical form of Alzheimer's 9:45 that occurs with menopause and often starts with depression. 9:50 Interestingly, as you know, ApoE4 is the common genetic association 9:55 with Alzheimer's, and that represents about two thirds of Alzheimer's. 9:59 And of course, women also represent about two thirds of Alzheimer's. 10:03 But these people, often they would be ApoE4 negative, 10:07 not all of them, but they're instead of having mostly ApoE4 10:11 positive, it was about it was more like about 5050. 10:15 So it didn't seem to be a big increase. 10:17 So many of these would be a 33 that weren't thought to be at increased 10:22 risk for Alzheimer's. 10:23 Nevertheless, we're coming in at 52 is a kind of the most common age. 10:28 I would see them and they were coming in with you. 10:30 I can't work my iPhone, I can't plan things. 10:33 And when we would look at them, 10:34 they would often have very significant atrophy in the brain. 10:38 And those people turned out as we started studying them, 10:42 they turned out to have what I labeled inhalational Alzheimer's disease. 10:46 So these people all have turned out to have 10:50 mycotoxin exposure and or tick borne illness. 10:53 And they they can do very well. 10:56 They have relatively young, healthy brains. 10:58 Otherwise if they get with the appropriate detox, 11:02 they get the appropriate treatment. 11:04 If they have tick borne illness. 11:05 And bright really helps them a lot. 11:09 And as you know, the pregnancy, 11:10 the progesterone is particularly helpful for detox. 11:14 And of course the estradiol particularly important for hippocampal support. 11:18 So these things are important, you know, and as we're starting to go 11:21 through all the data, one of the most important 11:24 mycotoxins is okra toxin A 11:27 and that one's made by Aspergillus or Penicillium. 11:31 You know, most of us don't know if we have exposure to that. 11:34 We don't know if we're living with Penicillium 11:37 and Aspergillus until we now start having some problems. 11:41 And it turns out that okra toxin A, which the mechanisms are fascinating. 11:46 It is an inhibitor of protein synthesis. 11:49 As well as preventing the re-up take of glutamate 11:53 which causes this excitotoxicity that, by the way, 11:57 excitotoxicity has been known to be part of Alzheimer's for years. 12:02 In fact, that's how Manticore works by adjusting that down. 12:06 So these people have this exposure and you can get this through inhalation. 12:11 You can also get it through ingestion. 12:13 So eating the wrong things. 12:14 And then of course you can also get it a third way from having endogenous 12:19 mold in your sinuses or in your gut is typically where these hang out. 12:24 So it's very important to find out if you do have exposure to this. 12:27 And the okra toxin A turns out to be a hippocampal neurotoxin. 12:33 So it actually does impact especially the very area of the brain 12:38 that is associated with Alzheimer's disease. 12:41 So I think it's very important for people to be aware of this. 12:45 So they catch it as early as possible. 12:48 You know, you have someone who's telling you, I'm really depressed. 12:51 I'm 52, 12:52 I'm going through menopause, I'm really depressed, 12:53 but I'm also having a little trouble at work. 12:56 You want to jump on that 12:57 and find out if this is what's going on, because it's so treatable. 13:01 And as you know, like any other chronic illness, 13:04 the longer you wait, the harder it is to get things reversed. 13:09 Well that's fascinating. 13:11 So how are you testing okra toxin? A? 13:14 Are you doing urine testing? 13:16 Are you doing antibody testing or how are you both. 13:20 Both. 13:20 And we've really followed 13:22 you know, we've really followed Doctor Richie 13:23 Shoemaker and Doctor 13:24 Neil Nathan and a number of the patients that I've worked with. 13:27 We consult with Doctor Nathan 13:29 because he's such an expert in this area and he's had great success. 13:33 And of course, he's written a number of books on things like the 13:37 the healing, the sensitive patient, that sort of thing, 13:40 and which are, which are so important in this whole field. 13:44 He's actually got a new one coming out. 13:45 So the, you know, understanding this, and we typically do it by urine, as you 13:49 said, urinary mycotoxins. 13:51 But it's also helpful sometimes to look at the antibodies in 13:54 the blood as well and get an idea, you know, where are you living. 13:58 Because so many of us don't realize. 14:00 And, you know, we've had a number of people where they improve and they go. 14:04 We had, for example, 14:06 a woman recently where she was on for six years and did absolutely great, 14:10 and then she really clearly had some back step, some decline again. 14:14 And I was like, what's going on? 14:16 Well, it turned out she had a reexport. 14:19 And so she had had new leaks in her roof. 14:22 And when they identified those and address those and she 14:26 then got back on her detox, she's done very, very well once again. 14:31 So these, these things, it's important partly because 14:35 standard of care medicine has not yet recognized this, 14:39 despite the fact it's a very common contributor to cognitive decline. 14:43 And so, 14:44 you know, more and more data are coming, but the associations are undeniable. 14:49 When you don't treat this, you don't see improvement. 14:52 When you do treat it as part of an overall precision medicine protocol. 14:57 You do see improvement. 14:59 And I see okra toxin A is epidemic. 15:04 It's almost like if I don't see it in a urine test, I start scratch. 15:08 Like, that's weird because I just see it. 15:11 It's in everyone and it is. 15:14 And there's such miskin like, I live, we're here in Arizona and so many people 15:19 think, oh, I'll move to Arizona because it's dry and there's no mold. 15:22 And we have a huge problem with mold here in Arizona. 15:27 Well, of course, Doctor Ackerley is right there with you in Arizona. 15:29 And she is a, you know, a real world leader in mycotoxin related illness. 15:35 Yeah. 15:36 So I want to just go back because you said something really important. 15:39 I just want to have you say it slower so the ladies can write it down. 15:43 You mentioned those couple of blood markers 15:46 that they could ask their doctors to run. 15:49 Yes. So it was the 17. 15:53 Yeah. 15:54 So let me explain those 15:55 because they're actually really important and they've just become available. 15:58 I mean, I remember, you know, 15:59 over 50 years ago when hemoglobin ANC was first being used, right? 16:03 And everyone was like, hey, wow. 16:04 We can we can now look at this and get an idea relatively early. 16:08 And of course later. 16:09 Then people started looking more and more at fasting insulin. 16:12 So you can look even earlier. 16:13 So are what's happened 16:15 is the markers where you used to have to do a spinal tap and you know, 16:19 who wants to get a spinal tap every few years? 16:21 I don't. 16:22 And so the idea now is, hey, will 16:24 these things actually show up in the blood and we can identify them? 16:28 And now there is a tremendous amount 16:30 of work, multiple multiple publications on association. 16:34 And so here's what's happened. 16:36 If you look at and there are really four major biomarkers, 16:40 if you look at to 217, that will tell you if it's in a specific range 16:46 over a certain amount that you have amyloid, the association is 16:50 with the amount of amyloid in your brain, which isn't a perfect marker. 16:55 The amyloid is an antimicrobial peptide. 16:58 It's there to fight the pathogens that you've been exposed to. 17:02 But it's telling you, you know, this is 17:05 you're on your way because it does decrease your synapse number. 17:09 It does bind to complement C1. 17:12 Q it is there. 17:13 It can have an inflammatory effect. 17:16 It is a synaptic removal effect.
Blood Biomarkers for Early Detection 17:19 It is a mitochondrial inhibitory effect. 17:22 It is it interferes with insulin signaling. 17:25 So it is part of your immune system so that you can get an idea. 17:29 So so tau 217 is fascinating 17:32 because tau is one of these proteins that has multiple jobs. 17:37 It's a little bit like if you go back to the Revolutionary War, 17:40 remember the Minutemen. 17:41 So these guys were there as farmer or as blacksmiths 17:45 and then boom, grab your rifle or go out to fight the British. 17:49 So this is like Tau. 17:50 What Tau does is it's normal day job is to batten down. 17:55 It's a it's like bolts on your microtubules. 17:58 So when you're holding and you're putting your neuritis out and you're 18:02 making these stable, you put tau along these things. 18:05 Now what happens. Pathogens come along. 18:08 Oh my gosh. 18:08 You got to now bring your immune system in to fight these things. 18:12 So you phosphorylate your tore. 18:16 It changes its charge. 18:18 It changes its shape. 18:21 It pops it off the microtubules 18:24 which then can can retract. 18:27 And it now becomes the phospho Tal 18:30 becomes an antimicrobial protein. 18:34 So it is involved with killing various pathogens now. 18:39 So you can pick when that phenomenon has happened. 18:41 And literally what we found in the lab is you literally have a whole set of things 18:47 for a mode that is connection mode and a whole set of things for protection mode. 18:52 It's no different than going from sleep to wakefulness. 18:55 A whole set of things change. 18:57 You're in sleep mode because you do certain things 18:59 well in sleep, such as detox. 19:01 Now you're in wake mode. 19:03 You do different things very well in wake mode. 19:06 Same idea here. 19:07 There's a whole set of things that happens in connection mode. 19:10 You're making new connections, you're maintaining them all this sort of thing. 19:14 But oh, you've now got all these pathogens. 19:17 You're going to have to put that aside for a moment, 19:19 unfortunately, and you're now going to have to go into protection mode. 19:23 And that's what's happening in Alzheimer's disease. 19:25 You are chronically in this protection mode. 19:28 So you are making amyloid. 19:30 You are making phospho tau. 19:32 You are trying to go after these pathogens. 19:35 You are changing. 19:36 You are reducing the trophic side of things. 19:39 Unfortunately, to use all of your wherewithal 19:44 now to fight these various pathogens and insults. 19:47 Same thing. 19:48 If you don't have enough support, you don't have enough blood flow, etc. 19:52 you can't maintain that connection mode. 19:56 So that's so. 19:57 So now what we're picking up in the blood is one of the sites. 20:00 And by the way, there are multiple sites on Tor that become phosphorylated. 20:04 But 217 happens to be the one that is most associated with amyloid. 20:10 Now when you get even beyond the part that's associated with amyloid, now 20:15 it's associated with amyloid and tau tau these the tangles. 20:20 So it's actually saying not only have you had to make amyloid against these things, 20:26 but you've taken that next step toward a pro-inflammatory state, 20:30 which is going to be more associated with cognitive decline. 20:34 So that's why if you see it over the years, 20:36 you can see it early before it goes up very much and we see it. 20:40 We're able to bring it back down. 20:42 You don't want to wait for it to be super high. 20:44 So that's one thing that's so helpful about. 20:47 And it's specific typically almost always 20:50 Alzheimer's, although there are a few other things that can bump it up. 20:54 And the ladies can ask their regular physician to run this at LabCorp. 20:59 You can. 21:00 So to be fair, LabCorp has a knock off the ones that actually the guys 21:04 that actually did all the research on this and have published and have done by far 21:08 the most validation and have the most sensitive test, that's neuro code. 21:13 And the easy you can get that directly. 21:15 Actually, you can actually get that directly if you go to get a brain scan. 21:21 So that gives you three things. 21:23 So phospho Tal which is about Alzheimer's and pre Alzheimer's. 21:28 Then the second one is 21:30 so that's 21:31 glial fibrillation acidic protein very much complementary to the other one. 21:35 That's not coming from the neurons that's coming from the the glia. 21:39 And it tells you that there's inflammation and attempted ongoing 21:44 repair in your brain. 21:45 A very good thing to know. 21:47 It's a very early marker. 21:49 So if you're a GFA is bumping up but your towel is still normal, okay. 21:53 Something's going on in the brain. 21:55 It doesn't tell you what it is, but you need to look further 21:58 to see what may be creating some inflammation. 22:01 The third one is NFL neuro filament light, 22:05 and that one will tell you if there's ongoing neuronal damage. 22:10 So for example, when I see people where all three are high, 22:13 they have very active Alzheimer's. 22:15 But I'll often see people where the Tao is high. 22:19 But the gap and the NFL are low. 22:22 So you have a more quiescent form. 22:25 And let's get in there and make sure that you turn things around. 22:28 The fourth marker is a beta 42 to 40 ratio. 22:33 Now the issue with that one, although it provides complementary 22:36 information, the issue is there's very little change in it. 22:40 Whereas the towel it's a robust test. 22:43 The A beta 4240 doesn't change much that one. 22:47 It goes down when it's abnormal, but it is an early marker. 22:50 So some people will include that one, others will not. 22:54 But those are the four major ones. 22:56 And the great news is, unlike even a few years ago, there are now blood 23:01 based biomarkers that you can get to see if you're on your way. 23:05 And again, just like everyone should know their hemoglobin A1, 23:09 everyone should know their tau. 23:11 217 if you're over 35, just get it every five years. 23:15 You know, to do it every five years is not onerous. 23:18 And you'll be able to see, oh, wait a minute. 23:20 You know, things are things are not looking as good as they were. 23:23 Because the great news is Alzheimer's disease doesn't come on overnight, 23:27 as you know. 23:28 And so we now know that it starts the pathophysiology 23:31 starts 20 or more years before the diagnosis. 23:37 So I'm asking for 23:38 myself as a doctor and other doctors are listening. 23:41 And then for patients who are listening, we shouldn't be running these 23:46 through like LabCorp request we should do get a brain scan. 23:50 This neuro code, it's going to be more accurate. 23:53 Is that what I'm hearing? 23:54 It's more sensitive. 23:55 It's more well validated. 23:57 Absolutely. Great. But, yeah, you can do it. 24:00 You know, you can do a quick knock off if you do it through the standard. 24:02 Yes, but this is the gold standard. 24:05 And these this one, this one also. 24:07 The other thing is this has several things that the others don't. 24:10 So this has a report generated that it will explain all the pieces to you. 24:14 It also if it's if you have even mildly abnormal,
Assisted Living Reversal Program 24:19 you will get a call from someone to say how can we help you next? 24:22 Nobody else 24:23 does that besides the, you know, besides what was set up with neural code. 24:27 So that's why we work with them. 24:29 Because, you know, we had our choice to work with everybody. 24:32 They're the ones that have the best test. 24:34 They're the ones that have the best follow up. 24:36 So that's why I recommend this. 24:38 But yeah, you can do one of the others if you like. 24:41 Fantastic. Okay. 24:43 That's very, very valuable. 24:45 So we were talking before we started 24:48 filming and I think it was some important 24:51 you were mentioning a study going on at the assisted Living. 24:56 Yes. And I'd love for you to share that with us. 24:59 Yeah. 25:00 So, you know, as a neurologist, the common story I would hear 25:03 was someone would go, they were having a little bit of trouble. 25:06 Then they would say, okay, I'm going to go to System Living and boom, 25:09 they just they fall off as you know, they would just fall right off the table. 25:12 Things go down. It's you know, it's stress. 25:15 It's a new environment. 25:17 They are often given zombified drugs. 25:19 As you know, the circadian are changing. 25:22 The diet is horrible. 25:23 It's an absolute mess. And people just decline. 25:26 So the question is can we do better? 25:28 Shouldn't assisted living be much better? 25:31 So several years ago, Dennis, who is the CEO 25:35 at a facility in in Fresno, amazing guy. 25:39 And he actually heard a couple of podcasts that I did and said, wait a minute, 25:43 you can actually do something about cognitive decline? 25:46 Wait a minute. 25:46 So let me do that for the people here. 25:48 So he then started looking into this. 25:51 And when we treat people we typically go, there are seven basics. 25:55 And then there are two specifics. 25:56 And the seven basics are, you know, plant rich, mildly ketogenic diet exercise. 26:01 You want to have both aerobic and strength training sleep. 26:04 You have the, you know, the four key targets. 26:06 You want to have at least seven hours of sleep, at least 90 minutes of REM, 26:09 at least 60 minutes of deep sleep, and at least a SpO2 of 94%. 26:14 I checked mine every morning. 26:15 See how I did last night? 26:17 And then you want to have stress reduction brain stimulation. 26:22 You can do with red light or brain train 26:24 or things like that detox and some targeted supplements. 26:27 And you know, supplements aren't a cure, but they are helpful when you're looking 26:32 at people who have low omega threes or low vitamin D or low zinc, 26:36 which is so common, low magnesium, another common one, and so forth and so on. 26:40 The armamentarium is huge now and growing for what we can do. 26:46 So Dennis said, you know, I got to do this. 26:48 And I should mention, you know, 26:49 the specifics are infections, what's causing inflammation and toxins. 26:54 And we want to address those. 26:55 Then it's going to be different for each person. 26:57 So that's the overall idea. 26:59 So we started a program there at the vineyards. 27:02 And they just had the cohort what I call cohort zero. 27:06 So it's the first group of ten. 27:08 And he actually has chefs that are now doing a what we call keto flex 12 three. 27:13 It's a plant rich, mildly ketogenic diet. 27:16 And by the way, we've just published a paper on this because it's 27:19 had such good effects on your support, on your metabolic flexibility. 27:25 As you know, you need glucose or ketones. 27:27 And many of us after 40, we're not utilizing either. 27:32 And in fact, you look at a Pet scan for Alzheimer's, 27:35 that's what the signature is, the lack of glucose 27:38 utilization in the temporal and parietal regions of the brain. 27:41 So there's your signature. 27:43 So we can restore that. 27:45 Both the ability to utilize ketones and the ability 27:48 to utilize glucose by having an appropriate overall protocol. 27:53 So he's got a couple of wonderful chefs who prepare this wonderful stuff 27:57 and these people. 27:57 So the first six months 27:58 now this is a 12 month program, but we just got the data back 28:02 from the first six months. 28:03 And it's absolutely striking. 28:05 So they had dramatic improvements in their insulin sensitivity. 28:09 Their homa IR on average went from 3.0, 28:13 which is abnormal, to 1.29, which is completely normal. 28:18 It was striking and they lost weight. 28:21 Their cognition was better. 28:22 So their memory scores were statistically significantly improved. 28:27 Their overall cognition was statistically significantly improved. 28:32 So multiple metabolic markers. 28:34 So I went down there to visit them just last week and sitting in that room. 28:39 So Teles ten people, each one of them went through their own personal stories. 28:43 We have some film on this, so it'll come out as being edited right now. 28:47 So you'll get the snippets and stuff. 28:49 Wait till you see this. It's incredible. 28:51 One guy said, I've had diabetes for 30 years, gone. 28:54 Another one said, you know, my memory is so much sharper than it's been. 28:58 One woman said to me, I came in here as a fat, old 29:02 ugly lady, and I now fit into the dresses I wore at my wedding. 29:08 I mean, just to hear these people, and they're all happy 29:12 and interacting with each other. 29:13 I never thought I would see that at an assisted living facility. 29:17 And, you know, I want to give great credit to the doctor, Heather Sanderson. 29:22 Heather came to our course when we first started this years ago. 29:26 She is a fantastic NPY and doing great job at Salisbury 29:30 with her partner with her business partner, Doctor Rachel Houston. 29:33 The two of them are fantastic and doing. 29:36 You know, I always follow all the outcomes. 29:37 They're getting great outcomes on their phones. 29:40 And so 29:41 she had the idea years ago for Marama, which was an assisted living facility. 29:45 Now Marama has been sold in closed unfortunately. 29:48 But she's going to open another one, I hope. 29:50 But she was really the the vanguard and said, you know, we should be doing this. 29:54 And she got some wonderful, you know, some wonderful improvements there. 29:59 But nothing was ever published from what happened at Marama. 30:03 So we're very interested. 30:04 Of course, you always need to show proof, you know, 30:07 is this just a fairy tale or is something really going on? 30:11 But when I saw the data and then I listened to these people 30:15 and there were people in the room as they were telling their stories 30:18 that were crying, because when was the last time you went to an assisted 30:22 living facility and people said to you, I'm so much better than when I came in. 30:26 I mean, this is within, you know, my hope is within this next few years, 30:32 everybody at assistant living Facilities will be doing this sort of thing 30:36 because it really does make a difference. 30:39 As you know, you eat a lot of junk, you sit around, you get depressed, 30:43 you do nothing, and people give you these drugs to quiet you down. 30:47 Things don't go well. 30:49 That's not a surprise 30:50 when you do the right things and you're getting the right sleep. 30:53 And they're working with the health coach. 30:55 The health coaches make a huge difference. 30:58 They worked with Lynn KMS, who is a fantastic health coach, 31:02 and with Wendy Davis, who's a fantastic nurse practitioner, and these guys, 31:06 they had the whole team there. 31:07 They had the right chefs, they had the right coaches, 31:09 they had the right, the right nurse practitioner. 31:12 They just turned around and did so, so well. 31:15 So it's great to see. 31:17 And this is proving to us that we can all do much, much better. 31:21 And of course, when the families come in, instead of them seeing decline, 31:25 they're seeing improvement. 31:26 Like, wow, you know, my mother still recognizes me, you know, 31:29 that sort of thing, 31:30 or my husband still recognizes me or my wife still recognized me, what have you. 31:34 And so it really is a heartwarming story to hear these guys. 31:39 And by the way, people would say, not only did my memory get better, 31:42 my arthritis went away in our we just finished 31:46 a randomized controlled trial for people with MCI 31:49 and early Alzheimer's at six different sites around the country. 31:52 And that was one of the things that Doctor Kat Toups was, who was the leader of the 31:57 of the six sites, pointed out, she had some people who were scheduled 32:02 for joint replacements, 32:03 and after the trial they didn't need the joint replacements. 32:06 So we're all seeing health can be improved 32:10 and cognition can be improved when you are doing the right things. 32:15 And at the assisted living, this was just dietary change. 32:19 This wasn't even giving them hormones. Correct. 32:22 So this was the yeah that's a great point. 32:24 So this was just the basics. Now what happened. 32:26 You can build on those. 32:27 And yes, some of them will absolutely be very good candidates for. 32:32 And actually you know what? 32:33 I have to go back and look. 32:35 It's possible that one of them did get one or even maybe two. 32:38 I'll have to check with Wendy, who is the one who followed with them. 32:41 But you're right, the vast majority of them did not get Bart. 32:46 So this was doing what we call the basic seven diet exercise, 32:50 sleep, stress, brain training, detox, and some targeted supplements. 32:53 In some cases, they did have some infections or some toxins. 32:56 So they had those addressed as well and they responded beautifully. 33:02 It's just fantastic because as I was telling you before we went live, 33:05 I had this this dream of just going to all the assisted 33:08 living and sprinkling hormones for everyone. 33:11 And I think, you know, I think the work you're doing, it's 33:14 like they, you could put assisted living out of business, right? 33:19 Like if people get this kind of treatment before they even go into assisted living, 33:24 they won't have a need for assisted living because they'll have all their faculties 33:28 with them. 33:29 And they could, you know, live independently. 33:32 And, you know, 33:33 I think that there will always 33:34 be people who don't do that and they will need assisted living. 33:37 But this particular facility, by the way, has independent living, 33:41 assisted living, memory care. 33:43 And they're actually Dennis is now building an entirely new building 33:49 that will be for cognitive support that will be using this approach. 33:53 So we're very excited to see that. 33:55 So I don't think we'll ever put assisted living out of business. 33:58 I think what we'll do is we'll change it to a happier place. 34:03 As you know, assisted 34:04 living has been an area that's just about depression and sadness. 34:08 I don't know if you saw recently there there was a new series 34:12 that was called The Burrows that was about assisted living. 34:15 And, you know, the guy was just grumpy and saying, you know, it's interesting. 34:19 They say, you know, we're going to have a new life here, he said. 34:21 We just go to die. 34:22 Well, that, you know, that's needs to be changed. 34:25 And what we saw with this cohort is that it can be changed. 34:29 This is not pie in the sky. 34:30 It's something that is already started. 34:33 And so if you can if you go to a place that has this approach, 34:37 you really can have a much better situation. 34:40 And by the way, in Marama, one of the people, 34:42 one of these initial people who came through 34:45 came in, had had some cognitive decline, went on the protocol, got better and left
Resources, Testing, and Closing Remarks 34:51 and said, okay, I don't need to be at this assisted living anymore. 34:54 So that's the future 34:55 where it's a place where people can come and go, not just come and die. 35:00 Yeah. It's amazing. Yeah, there's going to be on this word. 35:02 I'm interviewing Heather as well. Oh, great. 35:04 Yeah, she's a dear friend and. 35:06 Yeah. Amazing. Heather was amazing. 35:08 I love working with Heather and Rachel. They're fantastic. 35:11 Yeah. Well, this has just been. 35:13 I'm like, you know, just so beneficial. 35:15 Just the depth of your knowledge, the the hope you're giving from 35:19 this assisted living story, the practicality 35:23 of getting your labs tested and really knowing what's going on. 35:27 And, you know, just myth busting that Alzheimer's is a death sentence 35:33 and that there's not underlying things that can be addressed 35:36 is just such a gift to everyone listening to the world. 35:39 So any less things you want to share with the women listening? 35:44 Yeah, it's a new era. 35:45 Please don't wait. 35:46 And one thing you can do, 35:47 there's a free online cognitive assessment that everyone can do. 35:51 Go to my CQ test, CQ like Cognitive Quotient, 35:55 my test free online 35:58 cognitive assessment because as you know, this can sneak up on you. 36:02 So yes, if we're all proactive, 36:04 we can really dramatically reduce the global burden of dementia. 36:08 Beautiful. 36:09 Oh, and where can the ladies watching? 36:12 Where can they follow you and learn more about what you're up to? 36:17 Yeah, lots of places. 36:18 So I have four books out at the end of Alzheimer's. 36:21 The end of Alzheimer's program, the first Survivors of Alzheimer's. 36:24 We have seven people who wrote their stories, amazing stories to read. 36:27 And then the new one, the Ageless Brain, which is for all of us to say, okay, 36:31 how do we make it so that we don't have cognitive decline as we age? 36:34 We want for everyone to have their brain span as long as their lifespan, of course. 36:39 And then you can see on doctor Dale Bredesen on. 36:43 So you can see that on Facebook, on X, on Instagram, all of those. 36:48 And then there's also work on, on YouTube. 36:51 You can see as well from a number of the, the interviews, who just talked to Doctor 36:54 Richard Horowitz 36:55 a few days ago about his remarkable work with chronic Lyme and cognitive decline. 37:00 So lots of places that you can find the work awesome. 37:04 Well, go follow him, everyone. 37:06 Continue the learning. 37:07 Go do the cognitive test. 37:10 Do all the things this is, you know, 37:11 one of the most important talks we've we've had on the summit 37:15 about, you know, protecting and saving and healing your brain. 37:18 So thank you, Doctor Bressan, for being here. 37:21 I'm super grateful. 37:22 Thank you everyone for be here being here as well. 37:25 And I love you all. 37:28 And we will be back with another talk. 37:30 So stay tuned.
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