The Self-Cleaning Heart: How To Activate Autophagy For A Healthy Heart

Introduction to fasting and the summit 0:00

- Well everybody sit tight, don't move buckle up. This is gonna be a really really good 30-40 minutes I'm bringing the best of the best and one of the hottest topics in medicine for the reverse your heart disease naturally summit. And we're gonna be able to talk about reversing a lot of your health issues summit at least the science and the actual practical strategy. So I have with me one of the world's leading scientists and a topic that is literally as hot as any topic fasting, calorie restriction, fasting mimicking diets.

We're going to explain the difference in some of these terms Joseph Antoun, MD and CEO of L-Nutra company and beautiful Plano, Texas. Thank you for joining us, Dr. Antoun. - Thank you Dr. Kahn. Always a pleasure. And hopefully we're going to change somebody's life today. - Yeah. Many people now I we could fill easily half an hour with your academic scientific career. But why don't you give everybody just you know, two minutes on your training and your involvement now in science world in this particular field of science. Yeah. Well I'm an M.D treat patients all day.

And I wanted to be a cardiologist like yourself as well. And then and then doing my rotations, I started thinking about, well I'm putting I wasn't familiar with functional medicine, what you do. I was more on the on the allopathic side and we were putting people on pills every day for the rest of their lives and I wanted to change the health care system in a more preventative and true curative system. So when I did my Masters in health policy and masters in public health and started career in health system reform and advocating for to changes in the health care system.

And that that's not easy to do, you need to incentivize the system towards prevention and

Dr. Antoun's background and mission 2:06

create products so that products gets into policy and reimbursement. And it was like, what is the product for prevention? What is that one product that for one intervention it can help people stay healthy long or or truly cure health conditions. And after 15 years of traveling the world looking for it. A lot of researchers and top scientists were pointing at Valter Longo with the fasting, mimicking nutrition, it was a dietary intervention. But having the power of medicine and both in prevention and potentially now we're going to talk today about therapeutic fasting but potentially in therapy. I got fascinated by the topic of fasting and the science of healthy aging and rejuvenation and ended up after they carry a little bit with the biotech industry and see owing a consulting company in health care, decided to join a neutral fasting nutrition company and his mission to change the world through nutrition for longevity and here I am today.

- So for anybody that possibly hasn't heard that name, Valter Longo, PhD in University of Southern California half a year and a gerontology research center in Milan Italy half a year obviously native born Italian but spending nearly 30 years now in the United States. The highest funded researcher and nutrition in the United States from our Institutes of Health and other locations and probably one of the most esteemed if not the number one most esteemed scientist. So his relationship to L-Nutra was, he was the founder? - Yeah so Valter is the head of the longevity institute at USC. He started thinking about longevity 25 years ago coupled with nutrition and nutrition is the only product we put in our body every day.

So that was his actually tailored food to be the number one longevity driver and the number one for medicine and supplement to medicines. And and when he discovered the power of fasting and the fasting nutrition, he and USC decided to found L-Nutra our company L is longevity through nutrition and they founded it just to make the discoveries you know available for people around the world and and they stay very separate so it's all donated um all the all the ownership shares with that Dr. Valter donated back to create cures foundation and and all the science now we have 18 universities joining so we have the Stanford and the U.

C. L. A And the U. S. C University of Milan and Genoa in a lot of top universities in the world, they form this network of research on nutrition and they're studying our programs and random clinical trials to bring them to patients or to consumers to change their life with food. - And I have to say this with a little bit of comedy. The only copy of Dr. Longo's best seller international bestseller I had in my office was the Italian edition, the longevity diet. I'm sure for those of you that don't read fluent Italian there's an amazing English version and probably other languages.

It's more of an orange colored book and it's truly, I have so many copies in my office. I think it's the number one most read book coming out of my cardiology clinic is the longevity diet by Valter Longo. And I highly recommend it because you know we can't possibly talk about all that went into his background that culminated in L-Nutra and now you running what is a increasingly impactful company but you know people know fasting. I'm hungry, I'm hangry. I'm kind of upset but now we're talking about fasting as a therapy and may be

Valter Longo, L-Nutra, and the science network 5:55

defined for a couple of minutes. What would a scientist say is fasting? How long do you go with diminished or no calories for a scientist to say that's a human. There's three kinds of fasting. - There's the normal no food and if you ask any, you know any person on the street. What is fasting you know the the more physiological definition is when you start seeing ketones in the body. So you're you're you went you know long enough and typically this happens you know 14 hours 15, 16 hours when we do keto measurements is when we start detecting them.

Again it depends if you're skinny high metabolism, you exercise, you're gonna start getting those earlier if you have a little bit of you know more reserves and more glycogen in the body and your metabolic rate is low and you're not exercising that day you're gonna need 18-20 hours or more or longer. But we start seeing ketone production detectable in the blood. Between that 12 to 16 hours there's a third definition of fastening which we came up with or Professor Longo came up with is and this is where it allows you to consume some nutrition but that nutrition did not spike the recognition of the body of food. So when you eat the cards trigger insulin it's an anabolic you know and it's a signal of the presence of carb it's a growth hormone and then you eat proteins I. G. F. Insulin like growth factor increase.

So when you eat carbs and proteins typically these to spike in the body and they tell the body, hey, there's at the systemic level. We can go into an embolism. There's there's food at the cellular level. There are three main pathways for the cell to detect food the pKa And the rest of the tour pathways. And you know the tour is accelerated a little bit more by the protein, whereas the pKa And the rest by carbs. So the new definition of fasting with food is can you eat without using a spike in insulin?

And IGF So is how the fasting mimicking diet was born. It was a special nutrition technology that actually increases barely increases insulin and stays long and barely increased IGF and stays, you know, plateaus. And the similar pathways the pKa the tour and the grass pathways, they're not overly triggers so that the cell does not feel satisfied and that's now the new molecular definition or similar definition. - So for those listening, you can avoid a spike in insulin, avoid a spike and I. G. F. One by not eating at all.

But Dr. Longo and your team worked on a fasting mimicking diet that by keeping the protein content of a five day diet and the added sugar content of a five day diet very low. You get the physiology of a fast or nearly the same physiology, but you're not completely devoid of calories. I mean, I've never gone five days of not eating anything. I've done five days of eating the prolon fasting mimicking diet and can function very well as hundreds of thousands of people can give testimony to. So I mean it's brilliant. I mean that this actually happens.

Tell us about how we actually know this. The 2017 human randomized study what somebody might expect by taking a box of Prolon for five days and then eating carefully on the sixth day and then rejoining humanity, eating a clean, healthy diet for the rest of the month. And what did that study show?

What fasting means and how FMD works 9:26

- Yeah. And and people ask us why you why, why you want us to fast with nutrition? Why the invention of the fasting, mimicking nutrition of the fasting mimicking diet. You mentioned the name of the products called Prolon the entire objective is to help you go longer on a fast while not taking the risk of the fast if you water fast, you know, you have the the hungry, you mentioned the emotional side effects the hunger, the pain, the headaches. But there's also risk of hypo, you know, glycemia and lower blood pressure, et cetera. So this is where the food comes in to make it safe and compliant.

But why you want people to go for the five days, it's actually to cross the day two and three where the body says okay on day one and two, I always say you have a checking account savings account and a credit. The checking account is glycogen. So the first couple of days the body goes directly to glycogen to tap into calories to compensate the fast. Then it goes to fat. That's your savings accounts and then deliver those biblical genesis helps you a little bit with some credit. And that's enough for the first two days where there's enough of compensation mechanism. But then on day two, the body saying, I'm depleting my my reserve pretty fast and ask the cells to go and look for intracellular ways of saving energy is better performing.

And using the reason organelles in that process called out of A G. Or cellular rejuvenation. And it's a big word today. Won the Nobel Prize in medicine in 2016. And it starts around day to a lot of people think that if they do intermittent fasting, they pushed the 16 hours, 18 hours, they're getting into Auto Fiji. That's not happening 99.9% of the cases. It starts around day two or three. Again, we go back. If you're skinny, high metabolic rate you exercise, you might start reaching that on day one or between day one and two, you have more reserve. It takes you three days to touch on that.

But the power of the parole on five days is your most. People get a little bit 73% of Americans have some way to shed. So it's a great way to shed the weight. It's a great way to protect lean body mass. And now there's a pattern because fasting is a stress. The growth hormone is high. The muscle tone is there. You're nourishing withdrawal on the muscle. So you preserve lean body mass. As a cardiologist is so important for you because the biggest problem when people buy it, they lose muscle and fat and then they regain the fat but not the muscle. They become more insulin resistant and they go back to the next diet and they lose another cycle of muscles.

So with chrome on on the metabolic side, you're losing a lot of fat fast, you're preserving the body mass. But You're pushing yourself to rejuvenate, which is a critical improvement of biological age. And that's the essence of why we're a longevity company and why prolonged because the better you is a younger you you're not concerned about your first heart attack at age 40 and at age 35, you're not concerned about Alzheimer's at age 35, you're not concerned about most cancers at age 20. So the younger you is definitely the healthier you is is a you that has the power of you know, stem cell rejuvenation.

A younger cells are better performing cells and prolonged goal is to help you metabolically very fast. This is why now over over 14,800 clinics in the us are registered to recommend problem with us is a major metabolic benefit and we're gonna talk about that. But also it's very important that we clarify, there's a major cellular benefit when you fast, every cell of the body is going through that cycle because every cell lives on calories and every cell tries to resume. We need to survive, which is biologically helping you go slow down your age or get a step backwards and that's probably one of the best things you can do to prevent the onset of running. - Alright well that was an incredible provocative overview of what has been learned you know for now.

Like you said it's taken decades to create the fasting mimicking diet. And I think commercially available now is prolonged for is it fifth year anniversary and not quite yet. Fifth year. - Yeah actually it was the sixth this past month and we just crossed the one million on sold - Wow. You know we're gonna interview Dr. Alan Goldhammer from True North and talk about inpatient monitored water fasting for days to weeks. And they've had tens of thousands of people in 30 to 40 years. There's a clinic in Germany that is treated in the past 50 plus years. Maybe a quarter million people with inpatient carefully monitored water fasting. Nobody's doing these prolonged fast at home under any medical advice. But you've already reached one million in five years which is the practicality and the science. It's not a compromise.

I mean nobody has yet to my knowledge on five day water fasting versus five day pro on fasting mimicking diet. But I think you and I suspect we get relatively similar physiology even though you're allowed to eat a little bit within this amazing white box. Right? - It's actually very interesting a lot of people say and why there's no fasting mimicking Grishin versus just water fast. The I. R. B. Board is unethical Now today to push unless you mentioned the clinics that can do it. So if you're under clinical supervision definitely.

But you don't want to send people home and tell them live your normal life and exercise and run and it's just a water fast. But it's amazing in mice. We've done that and you see in many ways the fasting nutrition actually doing better and people is the intensity of fasting. Maybe they're closer. But what's very important I always say it's a funded rejuvenation with prolonged because if yourself wants to rejuvenate they're gonna still needs the minerals the vitamins if the muscle. And this is where where it's so critical.

People don't talk about muscle protection with with nutrition and diet which which to me is the most important thing. If every time you want to a little bit diet or lose some weight you're gonna lose muscle. That's the biggest disaster you can do because you're going to regain the weight pretty fast and just lose muscle and that's a vicious circle that people get into. Now if your water fasting. Yes there's the stress growth hormone is high, the muscle is pushed a little bit to grow but there's no food and so on water fast you're not going to have to you're not gonna have enough ammunition for the muscle to preserve the scroll on the fasting mimicking nutrition.

A lot of people ask us how come you have a little bit of high carb and the soups at night. This is where you want to spike a little bit further the insulin. And this is a big secret in the formulation because at night you have high growth hormone, you couple a little bit with a little bit of higher early kind of, you know, minuscule spike. And then the muscles are getting all the push and this plant based protein in the product. So the muscle is actually getting nourished and getting pushed to be preserved. And this is why you get out of it with fat cut but not muscle cut.

- So I think you've made a beautiful case, but I want to make sure that everybody just writes us down the science and a randomized study and in many animal studies is you lose fat with the five day fasting, mimicking diet, particularly visceral fat, which isn't only around the waistline and internal organs. That's where much of it is, where everybody wants to lose an inch or two or three.

ProLon study results and metabolic benefits 16:50

But you're not sacrificing muscle mass because we have data that as you get older, preserving muscle mass is critical. So it's like the perfect diet tool to lose visceral fat and not muscle mass. Whereas other programs, you know, just result in an overall loss and like you say, you get 70 years old and you try and regain your muscle mass. No easy job there and maybe impossible and maybe detrimental long term to shape. - You know, in random controls. We went against Mediterranean diet every day and and or five days and we went against medicine, you know, as you know, we just published with University of Heidelberg in Germany on diabetes and it took roll on just six months, meaning five days, only a month for six months, 30 days total to take 67% reduction in medication to drop HB one C by 1.4 and to decrease insulin resistance by 59%. And we always get these questions, how come you're superior to an everyday diet? How come just five days do all this?

And again, two secrets. Secret number one, you lose weight fast, but it's, you know, cutting fat, you're protecting muscle. Number two, you're getting your body biologically younger you at the younger age you were burning fat better. You were correcting yourself better. You did less mistakes, the less prone to chronic diseases. So the cellular rejuvenation key is very important. And cutting only fat while protecting muscle is key as well. - So if I ran into an elevator in an elevator and I saw you wearing a prolonged shirt and I said, what the heck is that? We're not saying it's a therapy yet, even though you just quoted a new publication, it's not an FDA approved therapy like insulin or Metformin. But I mean, what are some of the areas, I mean, what would you tell that person? It's a five day fasting, mimicking diet that can and some of the benefits you're allowed to say with the current regulations that you live within with the FDA. - I'll give you the elevators answer but I want to clarify that regulatory, it's changing and I'll tell you what has changed.

The problem is a five day fasting, mimicking nutrition that will help you get the benefits of fasting while you're consuming food. And these benefits are four categories. Number one is the fat loss while you're protecting lean body mass. Number two is a healthy aging and cellular rejuvenation. And that's based on the 2016 Nobel prize. And the data that we have number three, there's a big emotional transformation with Roland. You've worked with many patients on Poland and they will tell you, I just I just feel amazing. I feel empowered.

I've achieved. The diet is only five day. I always say this day one there's a day five and they feel empowered. They feel they have a better performance and better self esteem. And I can talk a lot about that because we have trials on depression and and and others that we just concluded and the fourth benefit is really changing your relationship with food when you do pro long you're saying, you know what I've done five days of a plant based diet. I wasn't addicted to big plates. I wasn't addicted to late night snacking and I just did it. So why to go back to my old habits.

So changing relationship with food is the fourth and and major um not least in major benefits with. So that's the elevator pitch. I want to go back to what you mentioned which is how to claim. You know and what are we allowed to claim And and you know, 67 months ago associations came together I think the American political diabetic association and others. And they came up with this definition of diabetes or disease remission and regression. And the definition is it's a lifestyle medicine intervention in non pharmaceutical and the definitions and non pharmaceutical intervention and that you actually if you show science you can you're allowed to talk about disease remission and aggression.

Disease regression means you need less medication, disease remission. It means you need no medication and you can see how this definition is actually probably was created to to say, okay if treatment and cure is left for medicine, diabetes obviously is a is a weight related lifestyle related disease. Most of it in the solution to diabetes was never built in a pill that as you know, most of the pills that just facilitate the migration of glucose from the blood to the tissue which in many cases end up stored in more fat and more insulin resistance.

So we don't see a lot of cure in diabetes from medicine. We see a lot of reversal and regression or lifestyle exercise, healthy eating etcetera and behavioral change. So they created this definition diabetes remission and regression. It's based on needing needing less medication or no medication. And this is how we're launching our diabetes program in Q one of 2023 is gonna be the fasting that we can die with a dietician to support and an app. And that program is going to be the first ever program to induce diabetes remission of aggression.

- So right as people are listening to this, they will want to go over to l-nutra.com or prolonlife.com and study this new available city of a disease management program for type two diabetics. I see over your right shoulder and I've got one right here. There is actually a one day Prolon called reset for those. I mean, how would you describe the people just putting their toe in the water before they jump in or doing this? We're not going to necessarily induce oughta Fergie and cellular regeneration.

But why did you design there to be a one? - It was, it was a popular request by the way, a lot of folks saying before I step into five days of fasting nutrition, can I try I can experience it for one day. Can I prepare my body for a healthy premium plant based protein diet. A lot of Prolon owners are saying, I don't want to go back to my necessary to all the time to my pizzas and pastas and burgers. I wanna maybe once a week or twice a week. And, and as you know, in Europe, it comes a little bit more from religious background.

They call it the 52 or the 61 fast as well where people twice a week, they do two days of fasting in them, in the, in the Christian rods. It's a Wednesday and Friday. A little bit of Muslim brad's, it's a Monday and Thursday. I think the prophet used to, used to fast. I'm not sure about the exact days, but it migrated from religion and end up being an intermittent fasting practice where it's called 5 to 5 days to eat whatever you want during the week and two days during the week. You fast a little bit of nutrition that is under 600 calories for male, 500 calories for female. A lot of people love to do the sixth one eating hay, I eat unhealthy and sometimes, you know, I overachieve during the weekend and go out and on a Monday, I want to reset. I want something to kind of wash out my sins or

Clinical uses, diabetes remission, and Reset 23:58

rebalance. So that's, this is how we launched this reset. And honestly got accelerated by NBA players, they were, I don't want to mention the big, big superstars in the NBA that we're buying prole on the five days and we're like, it's impossible that they're when they're active. We know there's a lot of professional players in all the leads, the major leagues, that role on when they're injured when an off season, they just want to cut fast fat. And we called the coach and we said, how come these big giant players that needs 6000 calories a day doing Croll on, He said, no, I just buy the box and every monday I put them on one day in order to watch the weekends partying, you know, habits. And so the combination of the science, a combination of history and, and, and, and the five do and the sixth one, a lot of people wanting to balance after prolonged to this product very clean plant based in a full day. Obviously a lot of us have got got issues and I don't wanna get into the details of, of what happens there.

But from a gut from away from a balanced perspective and from training yourself whether getting into prolon or keeping the benefits of for if you want to do it after the five. - And I don't know if I see it over your right shoulder. I brought one. There is a product that you guys make all the fast bar, which is an adapted basically the breakfast that you eat when you do the reset or the full five day parole on different. But tell us, I mean I'm still fascinated by the, you know, so much of l nutra is based on human randomized studies and you have one for this bar as a substitute.

So tell us what was the thought and what did you actually observe? Because I still think it's amazing. - They call us the fight of nutrition because of that every product we put out there, we do randomized control on including the bar that you just showed and there's nobody in the market controls and patterns. We have a pattern about olympic fasting. But the goal is a lot of people with the crazy and they're reading about out of Beijing and the science that honestly comes from parole on the five days that a lot of folks and coupled with the science on intermittent fasting away, it lost a lot of folks, a lot of Americans and people around the world started doing intermittent fasting and trying to get to 16 and 18 hours.

Again, there's not a major artificially happening there. Although this is what has been marketed, but it's a good way sometimes too if you want to lose weight to skip the morning in the morning breakfast. Although the recent science will tell you eat in the morning and at lunch and a little bit less and dinner. So front load your calories instead of downloaded towards the end. But if you want to skip breakfast and keep the same amount of calories, not over binge, then that's that that's probably a good way to get a good way to go. We don't believe in water fast.

We don't believe we do. We do obviously believe but fasting. But because you have a technology now that gives you the benefits while nourishing your essential organs. We came up with a fast car. So a lot of people skipping breakfast in the morning. They're starving at the same time. The essential organs. The brain, there are the kids. These organs have to work and they're calling for calorie. That's why you lose a little bit of weight. There's no switch happening there. We did the fast bar to provide the body with plant based proteins some carbs and some healthy mid chain fatty acids, fats for the brain so that you go through the morning fast in a healthy way in a compliant way. You don't get your headaches and your fingers and your and your fingers. - And yet in your study you the subjects maintained a low insulin level and a higher ketone level as if they had basically skipped that more meal. But they did 200 calorie bar.

That is very delicious. And it's very often my eight a.m. With a black coffee pre clinic. Yeah. It's a way to start the day. - I actually so we did another trial with coffee. We haven't published it. It's still if you do the black coffee you can add a little bit of stevia to it but not milk or sugar. And you do it with a fast bar. Your glucose is absolutely flat like water and your ketones. They barely a little bit dips that significant. But then they go overshoot over a water fast because of the fast part is designed to accelerate the fasting with mid train natural and healthy from academia ingredients. - It's truly, you know, if you didn't understand how profound the science coming out of your company and Dr.

Longo's research where you might say this is marketing and magic, but it's it is magic but it's based on nutrient technology science that so profound. And I if we had another half an hour we go into the cancer studies and the brain studies and all the areas of muscle and athletic performance studies. But I encourage everybody to continue to be a student. Maybe just because this is a reverse your heart disease naturally summit, let's finish with what you would tell. You know, you're an MD PhD, you can give medical advice or maybe you're lecturing to a crowd of cardiologists. What are possible ways that incorporating the five day fasting, mimicking prolonged died into a cardiology practice could benefit patient avoiding our disease or with our disease. - Well, I think 73% of patients statistically show that they have a little bit of overweight and then some 40% are metabolic syndrome, pre diabetic and a good 11,12% could be already in diabetes And that's the continuum where we love to position the fasting nutrition to support with because you're hitting on multiple angles. You're hitting on the the the fat loss one preserving muscle, any other diet you put them on.

First of all, they drop out is very high because they have to be on it every day. Number two, they're losing muscle at the same time. Number three they intervene, they impose on their lifestyle and and that's not a sustainable way for most people. Number two, you're helping the body coping with all the implementing processes. You know, fasting used to be in the books of autoimmune and inflammation in the old days and we see a lot of um improvement in the markets of inflammation. Body, which is important for both preventative and acute instead of in cardiology.

# three is really the power of cellular rejuvenation and regeneration again. The we in medicine and you and I went, you know, decades, a little bit to medical. We everything we we got trained on is that maybe a little bit of genetic predisposition and then given medicine towards it.

Fast Bar, intermittent fasting, and product science 30:38

I think what we're discovering is most diseases are related to lifestyle and aging and and the fasting mimicking fishin hits on both. It's very important to keep that body a little bit biologically younger because that's how it can deal better with how to stock less calories into fat battle inflammation support the reservation. We don't have data on your reservation or others. But a younger body is a body that's better. There is less prone to chronic disease and can better deal with acute settings and or post post. So it's a key to impact the shorter metabolic benefits and metabolic health. It's a key to impact to preserve the Muslim water while improving the body to better deal with any man.

- You know, having used pro on in my cardiology preventive clinic now for five years, I will say it has been one of the most powerful tools and I agree with you both the physiology and the psychology, the ability of the patient to get back in the driver's seat and determine their health and realize they don't need to overeat and they don't need to eat late and they don't need to eat tons of meat because it just is joyful that this is a very clean plant forward program. So obviously it jived right away when I read about it maybe last little bit that will shut it down.

You have a sister company if I can call it that called nutrition for longevity. And I'm not sure everybody listening and a lot of people listening know about it. So why don't you just riff on that for a moment and what that offers. - So a lot of people doing Prolon said I wanted to go back and eat healthy food and you inspired us is why the fastbar and reset where if you want to continue fasting after Prolon you continue with the fasting nutrition pipeline the one they reset the fasting bar but a lot of people they want to go back and eat you know pescatarian, flexitarian diet everyday healthy food. So we decided to put together this company called Nutrition for Longevity and basically merges three concepts concept number one is clean ingredients. We want to make sure that everything resource, it's organic, it's gluten free, it's a clean sourcing of ingredients.

Number two is the longevity formulation designed by Valter Longo as you know Valter studies centeneers around the world and and he travels all over the world to meet with them study the diets and we have a formulation which we believe is common to a lot of centeneers And again it's that border zone between pescatarian and flexitarian. So plant based and and some nuts within the gums and nuts within the plant based then fish is the main source of proteins and sometimes but really you can add other sources of meat.

And this is where the longevity formula sits on and then on top of that the third layer is we tailor the food the world's health condition based on the American heart association. American diabetic association and other associations. So we have tailored nutrition for kidney disease for heart disease for diabetes for cancer and this trio you know made us really shine very fast and 3.5 years to be one of the nutrition of choice for you know CDC And Medicare, Medicaid and many insurances and we we we became eligible for reimbursement in November of last year.

In between November and this august we already kind of past 59 insurances that they signed us for reimbursement. They're now paying for us as food is medicine. They pay food for a patient eligible for the

Cardiology applications and Nutrition for Longevity 34:18

food, the patient can get the food like a drug, no copay, no payments and we deliver the food every day. - So they are fully prepared delicious meals. You have amazing coffee. Amazing extra virgin olive oil I've sampled. And what you just said is incredible because it's actually I mean why would an insurance company offered to pay for it for a patient with a medical condition if there was an evidence but it's really probably one of the best examples between the five day fasting mimicking diet and nutritionforlongevity.com that Hippocrates food is medicine. You guys are just making it real making it available, making it meaningful. So I just want to say thank you so much.

Tell the person that wants to hungry for more. They want to learn more about Valter. He does have a website doesn't he? - Yeah ValterLongo.com to createcures.org He's active on twitter on Instagram I believe as well in a lot of videos including ted talks on YouTube. Amazing amazing you've been, in professionals changing the world and donating all of it back to into fund new cures as well and keep the pipeline alive. - And then if somebody wants to look at the, we've talked about three products the five day fasting, mimicking diet, the fastbar, the reset and I guess with nutrition for longevity would be the fourth product line. Where would be the best site to find that and learn more? At a high level if you want to read about the mission of the company and the product pipeline, you go to l-nutra.com.

L is for longevity dash nutra dot com. You can see the mission of the company and most importantly read the science. There's a science section there, which is second to none. There's no other probably interesting company has as many clinical trials and papers as we do. If you want to read specifically about each product, you can go to prolonfast.com for Prolon, you can go to prolonreset.com, for the one day fast or the fastbar.com, Nutrition for Longevity is nutritionforlongevity.com. You can see all the meals there and the benefits. - This is the only company that's a fasting company that everything's delicious. It seems the ultimate oxymoron but fantastic.

Well, thank you for your time. You're a busy man, you're all over the world and really, really changing. And this idea of aligning what you're doing with health insurance companies to make it available and actually a covered benefit is just wonderful. Good luck on the diabetes project. And from everybody at this summit reverse your heart disease naturally. Thank you very much. - I appreciate you very, very much Dr. Kahn.