Full Transcript Introduction to Exosomes and Miracle Cases 0:00 Hey there, welcome to the Recharged Biomedical Podcast. 0:03 I'm Dr. 0:03 Edward Park, and if you're curious about regenerative medicine, you've come to Hi everybody, this is Dr. 0:19 Ed Park, the host of the Recharged Biomedical Podcast. 0:22 And for today's episode, I'd like to talk about some miracle cases in exosomes. 0:27 This should elicit some eye rolls. 0:29 Everybody in the field of medicine, of healing, has their great anecdotes, and I'm no exception. 0:37 We'll end with my mom, who I think very happily and somewhat surprisingly has recovered from her horrible back condition. 0:45 But before that, let's talk about why exosomes would work. 0:50 So as many of you know, I am a doctor. 0:53 I started with training on stem cells, but I didn't find them as effective. 0:57 And over the last seven and a half years, i've been treating people with exasomes. 1:01 Exosome are how stem cell communicate with other cells to get them to de-differentiate and act younger for a time, even stem-like, 1:09 and this can result in regeneration of nerves, muscles, tendons, ligaments, cartilage, et cetera, which is why over 3,900 procedures and over 830 people 1:22 have trusted me and many of them repeat customers, including mom, who's approaching almost 50 treatments. 1:28 So we'll get to the great pictures and anecdotes, but first let's talk a little bit about evidence. 1:33 Okay, so the nature, as you know, of human experience is that we are storytelling creatures. 1:41 my conversations with AI have revealed. 1:43 AI suffers from a lack of persistent memory, of personality, or childhood trauma. 1:49 So it doesn't assign valences in the same way. 1:52 If we take it way, way way back to the origins of Ed Park, when I was about 10 months old, my family, mom, dad, brother and sister left on a road trip
Why Exosomes May Work 2:01 for about six weeks. 2:02 And I think that probably had some formative kind of effects on me in terms of bonding. 2:09 So I had to survive to bond with my new host family. 2:13 And when my real family came back, I wouldn't go to them for lack of trust. 2:17 What does that mean? 2:18 Perhaps nothing, but if you're a child psychiatrist, it might mean a lot. 2:22 I that's informed my way of attachment through the years. 2:25 Okay, enough about me. 2:27 My point is that humans live in a world of anecdotes i was just traveling in vietnam and in thailand and vienna my rented motorcycles and you would not 2:37 believe the way that people can put themselves there so many scooters and. 2:42 The dust and tourists everyone just goes when they want to go and ever wants it more. 2:47 with the exception of these extraordinarily long traffic signals. 2:50 So really, it's all just chaos. 2:53 And it teaches us something that there are no normal rules. 2:56 Likewise, I had a treatment two days ago with a doctor whose third treatment, we helped his shoulder, and he said, Ed, why aren't there any randomized 3:05 controlled trials? 3:05 Let's get this done. 3:07 And while I am definitely appreciative of the nature of evidence-based medicine, the answer to that is quite complicated. 3:15 So what was he saying? 3:16 He was saying that in order to really understand truth, we need to have a randomized controlled trial. 3:22 We need one case where ideally the patient and the practitioner are blinded to the treatment and see how the results vary. 3:34 This, of course, is the gold standard in evidence-based medicine. 3:37 And as an aside, I was enamored of this. 3:40 One of my early heroes was David Grimes, who helped to sort of invent evidence based medicine, and before that, what were we doing? 3:49 We were doing evidence base medicine but largely was based on dogma and anecdotes. 3:54 So quick confession, when I'm talking about it, it's just anecdots. 3:58 Over the 3900 procedures, i've seen some miracles and we're going to get to that real shortly. 4:04 But as fate would have it, I actually did a job interview with David Grimes in North Carolina Research Triangle, and he put me up for a position to go 4:13 to El Salvador, for Family Health International and the USAID program. 4:18 I went to el Salvador and taught for week in Spanish about the benefits of IUDs. 4:25 As fate had it my mentor, Dr. 4:27 Alan Rosenfield, who was also the son of the founder of We're not the founder, but the head of OBGYN at Beth Israel. 4:36 He was our mentor for the School of Public Health in New York City, Columbia. 4:42 And he invented the IUD in the seventies and gave it to Brazil and Mexico. 4:46 So when I was in El Salvador, which is a neighboring country, I actually met a gentleman who invented one of the anecdotes. 4:53 This is what it's all about, anecdots. 4:56 In order to discourage what he thought was a board of patients or the IUD, he told women that a baby was born with a cross in his hand,
Anecdotes, Evidence, and the Limits of RCTs 5:04 you know, the, uh, I U T and he was very proud of this. 5:08 So anyway, for a week I attempted to use evidence-based medicine to explain why. 5:13 The IUD actually causes an inflammatory reaction that kills sperm, does not kill fetuses or embryos. 5:19 But the power of that is that in El Salvador, that story and others like it had promulgated to the point where no one used IODs. 5:27 Whereas if you go to Mexico, the use is very, very high, 80 something percent. 5:33 Sometimes they'll pop them in right after your fifth baby without telling you, but that's a whole nother issue. 5:38 So we are ruled by anecdotes, you know? 5:41 Some people believe they put a man on the moon and Nixon was talking real time to them and they did it five more times. 5:48 Other people maybe not so convinced. 5:50 So, you know, some people will say if a glove doesn't fit, he must have quit. 5:55 And other people say, well, where's your randomized controlled trial? 5:59 So anyway, all that aside, AI and I talk a lot about epistemiology, which is the study of what can be known and ontology, 6:07 what really exists. 6:09 So we will touch upon those themes in a bit. 6:14 Ironically, after being an expert for the government and whatnot, the Government came after me for IUD usage in the local community. 6:21 I was treating about half my patients were indigent, Latin American, mostly Mexican patients, and the providers would use IODs from Tijuana, 6:29 which was gifted by Alan Rosenfield and Family Health International. 6:34 to Mexico so these FDA approved or registered factors would make them for very cheap like 70 cents and I asked some of the leading clinicians in my practice 6:44 what are they doing because we're getting charged 360 bucks and yet we have to get reimbursed 300 bucks for every IUD and they're the same thing just plastic 6:53 and copper And they said, well, we just go to Tijuana. 6:56 So I did that. 6:57 And over the course of like 14 IUDs, over many years of practice, they did a sting operation and I wasn't able to practice OB-GYN because Medicare said 7:08 I could treat their patients, but I couldn't be paid. 7:11 I had to resign from my medical practice. 7:13 My 17-year OBGYN practice so it kind of would have been a dark night at a lowest point. 7:18 But at that point, the TA65 had really taken off for me and transitioned into medicine of regenerative nature. 7:27 So we're seven minutes in, and I have just told you my origin story. 7:31 So let's go into what evidence really is. 7:35 Now, everyone would like a randomized controlled trial. 7:38 In fact, when I go to these conferences, stem cells, but especially the International Society of Extracellular Vesicles, 7:46 people look at me like persona non grata. 7:48 They're like, how can you be such a cowboy? 7:50 How can treat people? 7:51 Well, it's just based on anecdotes. 7:53 And I didn't do anything that I did to myself seven and a half years ago. 7:56 injecting my knee, my shoulder, and my Achilles. 8:00 And indeed, anytime something happens, even to the point of brain damage, I will treat myself and it appears to help anecdotally. 8:06 It's important to realize that in the evidence-based realm, anecdotes are still evidence. 8:12 Lower quality, sure, but over the course of seven and a half years of practice, we've amassed a lot of good anecdotal evidence, 8:19 which we'll share with you in a bit. 8:22 So yes, there are about a dozen FDA trials going through with MSC exosomes, and hopefully we can have off-label use once any of those gets through. 8:31 But the whole landscape of intellectual property ownership, of the secretion of a cell, not even a patented thing is dubious and unknown, 8:42 let's just say. 8:44 I think that I'd like to start with some great pictures from my phone. 8:49 As I lean forward, I don't see the bald patch I used to see. 8:53 So I had my mom, she was too much of a sadist, so I have to take the needle from her, and it looks like I've grown more hair in that baldpatch,
Personal Background and Shift into Regenerative Medicine 9:02 which I only revealed through podcasting. 9:06 If you look at me, I'm 59 and I just spent three weeks playing seven rounds of golf and riding hundreds of kilometers around on motorcycles in Vietnam. 9:14 I think I am okay health-wise. 9:17 Whenever there is an injury I will treat it and it will go away. 9:21 What does that mean? 9:22 Why do I have all this black hair? 9:24 I had some whiskers that are white, but I think it's because I've been taking 18 years of TA65. 9:31 You may disagree, I do think that it helped me to lose my visceral fat, so now my subsistence on pizza, beer, and donuts doesn't affect my visual fat as much. 9:41 And I seem to be staying young in that regard. 9:44 Also I can read this close up without reading glasses. 9:48 These are for astigmatism, which is very unusual for someone of my age. 9:53 And indeed, when I was 40, I had reading classes and I. 9:57 Was getting gray hair. 9:58 So is that relevant information? 10:01 Perhaps, perhaps not. 10:02 It is what I attributed to. 10:06 So I think we have to be very humble about what we know, what think what know. 10:11 One of the interesting things in the last dozen years, I met a lady, Antonia, who after 10 years of knowing her, she said, 10:18 oh, we were related in a past life and that's a whole other story. 10:23 The first time I met her 12 years ago, I didn't believe in spiritualism per se or Kundalini awakenings, but she did a treatment on me, 10:31 which consisted of her saying, you're safe, just breathe. 10:33 And she was ostensibly moving energy. 10:36 During that first 30 minutes, went back to what psychiatrists would think is a golden ticket. 10:42 I went to childhood, perceived trauma as sort of the ghost of Ebenezer Scrooge, saw my mom and dad in conflict situations and resolved that. 10:52 as the child who was being imprinted and traumatized. 10:55 And I realized afterwards she said, if you tell anybody that I healed you, I will sue you. 11:00 I thought, oh, she's just being humble. 11:02 But it's quite true. 11:03 She had no preconceived notion. 11:05 she didn't tell me anything. 11:06 Didn't say, tell about your childhood. 11:08 It was an auto program of my spirit trying to be cleansed or healed. 11:13 The remarkable thing was it caused a buzzing in my body of electricity, which some people call, couldn't want any awakening. 11:20 And I thought, well, isn't that weird that I went back to the childhood, reassessed everything, gave a different valence, 11:26 and for the first time since I can remember, I was able to look in the mirror without negative judgments. 11:31 So that was quite the interesting experience. 11:34 If we talk about epistemeology, didn't used to believe in reincarnation. 11:40 Now I'm sort of 50-50, reserve judgment. 11:44 So many people a couple years ago came out of the woodwork and were telling me very vivid and specific stories about it that I've kind of moved the needle on. 11:51 So with that kind as a leitmotif, try not to be too skeptical about what you know. 11:56 It is plausible and the majority of world, as my friend Tamara used to say, does believe in reincarnation. 12:03 So let's scroll through my phone and see a couple of great cases. 12:07 Speaking of hair loss, here is a gentleman who came to me, works on movie sets, and had a lot of physical trauma, which we did multiple injections, 12:16 so many all over his body, including his plantar fasciitis. 12:19 And after that helped us resolve all that, he said, can you do anything for my hair? 12:24 And I said sure, we'll try. 12:25 In all fairness, I used a product which is no longer available, amniotic fluid exosomes with regular exostomes, these are the results. 12:34 Now he came back and said, as people often do, oh, I think it's just a row game. 12:38 I asked him, have you ever taken row games before? 12:40 He goes, yeah, been taking it for years. 12:42 So that tells you the attribution bias was like, hey, know this stuff works, don't want to pay for it anymore, and I'm good now. 12:49 There's one good case. 12:52 Another patient here on my phone is a lady who came to me after Bell's palsy, which is the paralysis of many different regions or reasons on the face.
Case Studies: Hair, Bell's Palsy, and Gut Issues 13:02 And six weeks later, this is her face, so she was quite happy with that. 13:05 Another one I love to show is Hungarian man who cared to be at the very beginning of my practice, maybe six years ago, and he wasn't expecting anything. 13:13 He was suffering from leaky gut, To his credit, over the next two, three weeks, he documented all these amazing images of his eczema clearing up, 13:23 his spider veins on his legs clearing, up his appearance becoming less inflamed, and his diarrhea and leaky gut symptoms completely resolved. 13:35 I think the only reasonable explanation was something I didn't used to believe in. 13:39 Even after interviewing Perlmutter and hearing patients talk about gluten sensitivity, I was like, this is kind of overdone, 13:46 isn't it? 13:47 But since then, there are some people who have leaky gut, who are leaking food in there, causing a mast cell activation and these kind-of untoward symptoms. 13:57 And when I show people these images, they're like this has got to be fake or Photoshopped, but I assure you, it is not. 14:05 Another great interview we did recently was with Isabel Amico, and I think, you know, things happen for a reason. 14:12 And so I met her about two years ago through Melissa and Duncan, who are proprietors of the Chimera Labs exosome company that I use. 14:21 They asked me to help her. 14:22 It helped her with her menstruation. 14:24 She was eight years menopausal with very low anti-malarion hormone. 14:30 And since then she's received many injections, perhaps 12 of high dose exosomes, and it has caused her to begin cycling after an eight year period of amenorrhea 14:41 and a strong family history of ovarian failure. 14:43 Even cooler than that, she just got back a month ago from three months in Poland doing Dancing with the Stars, was able to avoid injury, 14:51 also taking TA65 at the time. 14:53 and was one of the most interesting and fun chapters of her life. 14:56 And she continues to get treated, I just treated her two days ago with IV and with nasal. 15:02 The nasal's helping her think better and complete her brilliant comedy screenplay. 15:07 So check out her podcast where she describes that. 15:10 I think you'll be fascinated. 15:11 We have many people, speaking of nerves, where we're going to be at the IMMH, or the Institute for Mental Something Health, 15:20 and we are going be talking about autism. 15:24 One of my colleagues took the online training course, which many of you are in, and he helped his son, who is non-verbal and autistic. 15:33 And he's helped dozens of his own patients in this practice. 15:36 It's really, in his opinion, transformed it so much so that he added three modules to our online trading course for doctors. 15:44 He'll be giving a lecture at the conference on mental health in October. 15:49 Anecdotally, another great interview was with Jody Ripko, who she didn't really talk about the benefits, but also has a profoundly autistic non-verbal 15:57 son whose social anxiety, whose apraxia, fine motor skills greatly improved, and she is treating other families and kids as well. 16:05 Which brings me to a kid I don't have a picture of, for treatment in a clinic in New York, and he had his mom and two aunts hold him down. 16:14 He was so kinetic, like 70 pounds, 12 years old, was afraid of what I might do to him. 16:20 That he wouldn't allow me to even come close to them. 16:23 But now his Mom is administering nasal inhaled because he's no longer combative and is much less anxious. 16:30 And interestingly, he developed autism after a COVID vaccination and was neurotypical until the age of nine and now at 12. is finally emerging from this 16:42 profound hyperkinetic combative autism. 16:47 Another person, there's very few who've taken high-dose exosomes over many years, but I call him the most interesting man in the world. 16:53 You know, the Doseckis commercial. 16:55 He looks like the actor, probably even better looking. 16:58 Very muscular. 16:59 And he was training in his 70s on Muscle Beach with football players like Lyle Alzato.
Hormonal, Neurologic, and Autism-Related Cases 17:05 Has been a concert promoter. 17:07 I called him, The World's Most Interesting Man. 17:09 Knows Gavin Newsom and his wife quite well. 17:12 about that. 17:13 But he has gotten a lot of exosomes over the years and he believes it works. 17:19 He just turned 80 and has been telling me about his dating life for many years. 17:22 It's kind of like he and I are both struggling with the apps and the catfishing and all that but at any point he finally found some dates and he was bragging 17:34 in a way I can't describe about his exploits and it's quite gratifying to know that not only is the gray hair going away on his head, 17:41 his eyebrows, and his belly, but he had six years of no erections, meaning no morning erection, no erections when your bladder is filled, 17:49 because of probably nerve damage from eating a lot of fish. 17:53 And the fish, the larger fish could concentrate the mercury. 17:56 So he had mercury poison, which he actually had to detox himself out of. 18:02 But now he is dating a 36 year old and apparently everything is swimmingly well for him in that department. 18:10 We get to finally my mom, who three months ago could not walk. 18:14 She had been in the, she discovered about four years ago, casino gambling, and she would spend five days a week, 18 hours a day just hunched like this. 18:23 hitting the machine and that her back did not like. 18:26 And this is a woman who is status post, meaning she had about 16, 18 years ago, a lumbar fixation with Harrington rods. 18:35 So she has a history of back problems, but this lifestyle caused two discs to herniate so much so that three months ago she couldn't walk. 18:42 I had to literally give her a piggyback ride from the parking lot to my apartment where we did an epidural treatment. 18:48 And this testimonial, which I'll show you, says that within 10 minutes, some of the nerve pain was decreased. 18:55 We see that a lot. 18:56 Wasn't severe. 18:57 But the last two days, the pain... 18:59 The last 2 days I cannot even walk. 19:01 Shooting down your back, rating to the inner knee, right? 19:05 L3. 19:06 Yeah, L 3. I see the picture where shooting pain comes down. 19:12 So we did the shot, what, 10 minutes ago? 19:14 15 minutes? 19:15 Yeah. 19:16 By the way, I couldn't cross my leg. 19:20 It was painful. 19:24 You can cross it now. 19:25 Yeah. 19:25 Okay. 19:26 Good. 19:27 No headaches. 19:27 So that means we didn't puncture the lumbar sac. 19:30 That's good. 19:31 All right. 19:32 We are trying to make it, you know, the cat back position like as much as possible. 19:38 And I, did I charge you extra? 19:40 Cause you're my mom. 19:42 You're trying the charge less, but this is worth it. 19:46 12,000. See the side neck, spinal punctured 12 thousand. 19:50 They charge it all right? 19:52 Okay, good job. 19:54 I think it's worth it. 19:56 Ten thousand. 19:57 I don't mind paying you ten thousand I'm not joking. 20:01 My pains are almost gone. 20:03 Wow, that's great. 20:05 Great. 20:06 And I did your taxes for free. 20:08 Yeah. 20:09 Geez, what a bargain. 20:12 But really, it wasn't to the point where she could even stand living. 20:17 She was very, very depressed. 20:19 Well, she didn't really do depression, but she was not happy. 20:22 To put a $5,000 deposit on a wheelchair van, was gonna buy a wheel chair, saw a back surgeon who quite disingenuously said, 20:32 well, why get an appetizer when you can get the whole meal? 20:34 Let's just do another spinal fixation. 20:36 For those that know, More fixation of the lower back mechanically will just cause cascading stress above and below But she doesn't listen because she is 20:46 a tiny tiger mom And so she got a second injection of epidurals and now fast forward three months later. 20:52 She is doing fine I didn't think necessarily it was going to work. 20:57 I also have the placebo effect. 21:00 And I'm trained in the Western tradition of skeptical evidence-based medicine. 21:04 So with an N of zero, how can I say that even though most people do get better from epidural ejection, my hope was that it would heal the disc, 21:13 heal ligaments keeping the discs in, and relax whatever inflammation there was on the nerves. 21:19 And I am very happy to say that she at 89 is now pain-free, her sciatica is gone, and something must have happened. 21:26 You may not believe it, but that is the case. 21:29 Indeed, when I came back from Vietnam three, four days ago, I said, oh, you don't have to pick me up from the airport. 21:35 And yet she rallied and around midnight, this 89-year-old woman got in her car and picked me at LAX and is still very, very sharp and very very on it in 21:44 terms of her business. 21:45 and her life, and luckily she got the deposit back on the van. 21:50 So I said, Mom, if you go into a wheelchair, that's it. 21:53 You're going to lose functionality. 21:55 If you're into major surgery, you might not emerge the same. 21:58 And for some crazy, non-evidence-based reason, she is fine and we're grateful for that.
Mom's Recovery and Closing Thoughts on Exosomes 22:07 At the end of 22 minutes, I hope I've described to you why I think exosomes are good. 22:13 You may not believe, but you know, the majority of my patients are repeat customers and they repeat because like Dave Asprey here, 22:20 his back and his whatever glute no longer hurt. 22:24 We treat people's knees and then they come back for something else. 22:27 So it is my contention that this is like a panacea and it can help, doesn't always, can't help in a lot of different things. 22:35 It helps to believe, but just like my Kundalani faith healing, you don't need to know what's going on for the body to have a positive effect. 22:43 Because even though all those scientists and serious people at the Existome Conference would not even give me the time of day, 22:52 they at at same time cannot dispute the animal studies, the science, basic mechanism of how Exisomes work to heal us and to repair. 23:03 It's up to you whether you want to try it, whether want you to learn it to treat your patients. 23:09 Yeah, it's a low quality of evidence, but nonetheless, if you are somebody who is struggling with neuropathy and your neuopathy goes away, 23:19 like my good friend Gloria, who was an OBGYN surgeon who I met many years before, had debilitating facial nerve, actually trigeminal nerve pain, 23:30 was on multiple meds and wanted to die, and then one nasal exosome treatment just resolved that apparently. 23:38 or you could believe that it was something else. 23:39 But at any event, what we do is often helpful, not always. 23:45 Having faith in the therapeutic relationship and the mechanism helps. 23:50 Again, even if you get a bunch of new hair growth, you can attribute it to whatever you want. 23:54 You can choose to believe, choose not to But we're out here doing something that is not without scientific evidence, not with a plausible mechanism. 24:02 And by all of what we used to call in public health coax postulates or the ability to determine whether something is causal or coincidental, 24:11 it seems that we are able to help a lot of people by using exosomes. 24:16 So anyway, if you like this content, like and subscribe, hit the notification bell. 24:20 Love to see you in the next episode. 24:22 As synchronous as you would have it, a person just contacted me, their assistant, to interview them and see if I can get the title right. 24:30 It's exactly the theme of what I wanted to talk to you about today. 24:37 And so I think next week's podcast will be, what happens when normal doesn't explain the patient? 24:44 A founder's search for answers. 24:47 So I ask you all to take a leap of faith, just a tiny one. 24:51 And you can read my book, Exosome Songs of Healing, to understand the mechanism. 24:55 But yeah, ethically, you know, we don't overcharge. 24:58 We try and customize, but I do think that there's a better than not chance that can help with a variety of conditions and that's why it's so gratifying 25:09 to be practicing medicine in space and hopefully this will have some meaningful results for practitioners, for patients, 25:16 loved ones, etc. 25:18 So, Dr. 25:19 Ed Park signing off, rechargebiomedical.com. 25:22 You can also find me on Substack at d-r-e-d-p-a-l-k, I believe. 25:27 Take care. 25:28 Thanks. 25:30 I've spent years studying how cells age and why we age, and about cell communication. 25:36 Exosomes are now changing the way we understand cell communications and providing an opportunity for us to reverse some of these problems. 25:44 Pick up a copy of ExoSomes' Songs of Healing and in simple English I explain how this is working and the future of medicine. 25:53 go to www.rechargebiomedical.com, subscribe to my sub stack at DREDPARK and watch my YouTube channel at DRPARK65. 26:05 Thanks so much. 26:06 Many clinicians are getting interested in exosome therapy and they hesitate for good reason. 26:12 Questions like, does this work? 26:14 What forms do I need? 26:15 How much should I charge? 26:16 how do i stay out of trouble? 26:18 All these questions are addressed in my online course. 26:21 That's why I created it to help you get started. 26:24 The online courses is your permanent turnkey resource to get start either treating yourself, friends and family or to expand your practice and help more 26:34 people as well as increase your revenue. 26:35 Thanks for tuning into the Recharge Biomedical Podcast. 26:39 If today's episode got you thinking, you'll love my book, Exosomes, Songs of Healing. 26:44 It's packed with cool analogies, full color illustrations, and all the science you'll need to understand how exosomes are changing the game in aging and 26:53 regenerative medicine. 26:54 You can grab it in paperback, ebook, or audiobook, whatever works for you. 26:59 Now head over to www.rechargebiomechanical.com to check it out. 27:05 And don't forget to like and subscribe so you never miss another episode. 27:09 See you next time.
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