Full Transcript Introduction to Dr. Nafysa Parpia 0:00 Welcome back to the Bioregulator and Peptide Summit everybody. 0:02 I am so excited to introduce our next speaker because this conversation 0:07 since right at the intersection of everything we are here to explore. 0:11 Doctor Nafysa Parpia is a natural doctor and a partner physician 0:16 at Gordon Medical Associates, one of the most respected integrative 0:20 medicine practices in the country, known for tackling the most complex, 0:25 chronic and misunderstood conditions in medicine today. 0:29 Suffice to say that courage is not something in short supply over there. 0:33 A lot of doctors don't even want to go there. 0:35 Doctor Parpia specializes in chronic, complex illness, 0:39 thinks Lyme disease, co-infections, mold toxicity, 0:43 autoimmunity, MCA's and long Covid, which we're going to talk about today, 0:47 and the intricate web of dysfunction that weaves them all together. 0:52 What makes her work so relevant to 0:54 this summit is that she approaches healing at the cellular level, 0:57 looking at mitochondrial dysfunction, immune dysregulation, 1:01 and the very biological terrain that peptides and bio regulators 1:05 are uniquely positioned to address 1:07 when used at the right time and in the right way. 1:11 She is a sought after speaker, educator, and clinician who bridges the gap 1:15 between cutting edge science and real world patient outcomes. 1:19 Her patients are often the ones who've been told 1:21 there are no answers, and yet she finds them any way. 1:25 Today, she's going to share her 1:26 clinical insights on how bio regulators and peptides fit into the treatment. 1:30 Specifically, we're going to talk about MCA's. 1:33 And at the end, we're going to touch on long Covid as well. 1:36 And I promise you, 1:37 this is going to change how you think about what these compounds can do. 1:41 And if you're a clinician, how you apply them in practice 1:44 please help me welcome doctor Nafysa papaya. 1:48 Thank you so much for taking the time to be here. 1:50 Nafysa, thank you for having me. 1:52 Such a pleasure. Always. 1:54 All right. 1:55 Well, let's start with if you could please just define to people. 1:59 If people are not really familiar with MCUs, maybe let's give them a short 2:02 definition of MCUs. 2:04 What's going on and go from there. 2:07 Great. 2:08 So MCUs mast cell activation syndrome. 2:11 This is when the body's alarm system in their immune 2:16 system gets stuck in the on position. 2:19 So patients start reacting disproportionately to foods, 2:23 sense chemicals their own hormones stressors. 2:28 And there's no rhyme or reason to why this happens. 2:32 People get very confused because they then have symptoms across 2:36 virtually every system of the body. 2:38 And there's a reason for that is because mast cells exist in virtually 2:41 every system of our body, in our gut, in our brain, in our bones. 2:46 They're wrapped around our nerves, in our genital urinary tract. 2:49 So when we have symptoms in virtually every one of these systems, I'm 2:52 thinking about mast cell activation syndrome. 2:55 And I've yet to meet very many patients
What Mast Cell Activation Syndrome Is 2:58 who have a diagnosis like long Covid, chronic fatigue syndrome, fibromyalgia, 3:04 various autoimmune conditions, chronic Lyme and co-infections 3:08 who do not have mast cell activation sentiments rare that they don't have that. 3:12 So we need to work on this for all of these patients 3:16 in order for them to be able to tolerate the treatments, 3:19 because if you've got MCUs, they're even going to reject their treatments, 3:23 whether it's peptides or bio regulators or herbs or nutraceuticals 3:27 or pharmaceuticals, anything gets rejected. 3:31 So we have to calm that first. Beautiful. 3:33 So how do you do that? 3:34 Like, I mean, you know, because the temptation is to say, 3:37 let's just stabilize those mast cells, right. 3:39 And I think that's probably the first step, except that the step 3:43 before that is identifying or you tell me, 3:46 is the step to identify what's triggering the mast cell activation. 3:51 Or do you just say, look, we just got to stabilize these things 3:55 because regardless of what's triggering them and we don't even 3:58 and you may not even know all the things that are triggering them, 4:01 is it possible to stabilize them and then kind of start 4:04 to figure it out, like how do you figure out where to go first? 4:07 What's first, the chicken or the egg? 4:09 You know, it's such a good question. 4:11 I'm always testing my patients to find out what those insults are. 4:15 Now, with these patients 4:16 that have these diagnoses I just listed, they've got multiple insults going on. 4:21 They've got multiple low grade chronic infections going on. 4:24 Usually I seen Lyme and co-infections, parasites, issues 4:28 with mold, multiple different viruses, particularly in the herpes family. 4:33 They have different colonization and different sites of their body. 4:36 This is very common. 4:38 The sinuses, the gut, the gentle urinary tract, some people, the lungs. 4:42 So I'm looking for where that slew of chronic infections are in these patients. 4:48 They also have a high load of environmental toxins 4:51 microplastics, metals, glyphosate solvents, pesticides. 4:56 They have high levels of stress and trauma. 5:00 The trauma of being sick itself is enough to cause some immune dysregulation. 5:04 They also many of them have had adverse childhood events, 5:07 but many of them have not had a big T trauma. 5:10 Could just be the little T 5:11 traumas that they're nervous system is super sensitive to. 5:14 So when I'm going back to your question, right, I, I want to do all this testing 5:20 because I need to understand exactly what the insults are. 5:23 There are many, many insults causing the mast cells to flare. 5:27 So I'm going to do their general labs first, their CBC, 5:31 their their their thyroid panel, their sex hormones, the basics. 5:36 And I'm going to stabilize mast cells while I'm waiting for the other labs 5:41 to come in to determine what those multiple insults are, 5:45 because it's going to be different for each patient. 5:49 Yeah. 5:49 No that's I mean yeah. 5:51 So it's a bit of chicken and egg at the same time. 5:53 So and I guess you know 5:54 what's interesting is I think that what happens with a lot of patients 5:58 with MCA's and correct me if I'm wrong is you're kind of fine until you're not. 6:02 And so your body's able to tolerate some of these things 6:07 for a period of time, and everybody's got a different threshold. 6:11 And at some point the buckets 6:12 going to overflow based on whether it's a new traumatic event 6:16 or it's a new one of these pathogens or one of these factors, 6:21 all of a sudden just overwhelms the body's capacity to deal with it. 6:25 And everybody's going to have a different threshold. 6:27 And I'm guessing 6:28 in your patient population, the threshold becomes quite low. 6:33 It does. 6:34 So for some people, it's this one day all of a sudden, 6:38 and I can remember the day and then give me the date. 6:40 This is when my life changed and I became sensitive to everything for other people. 6:44 It was this slow, insidious process. 6:48 They could eat 20 foods and now they're down to five foods. 6:51 And that process took 3 to 5 years. 6:56 So everyone's. 6:58 Yeah, yeah. 6:59 That's crazy. 7:00 The way the way it appears is different. 7:02 Okay. 7:03 So what we the promise at the beginning of this episode was that 7:06 what we were going to talk about is at what point is it appropriate
Finding Triggers and Stabilizing Mast Cells 7:11 to bring in some of these tools, like the peptides and the bio regulators? 7:16 Because I think that in the space of peptides and bio regulators 7:20 right now, there's a general there's well, there's two camps, right. 7:24 There's the camp of they're not tested. 7:26 They haven't been tested on humans. 7:27 They're useless and or dangerous. 7:29 And then in the second camp, 7:31 you have people that are like, oh my God, this is the solution to all my problems. 7:35 And all I need to do is get my hands on these peptides, come, hook or by crook, 7:39 throw them at my body. 7:40 My body is going to know what to do and I'm off to the races. 7:43 I would say that the people on the right live in their own little world. 7:47 The people on the left are potentially 7:49 setting themselves up to get really uncomfortable because. 7:53 Right, you're gonna you could throw yourself, 7:55 your body into a complete tailspin by using the wrong thing at the wrong time. 7:59 So maybe if you could not by giving us the prescription, let's say, 8:03 but by helping us to build a roadmap for people about the steps 8:08 that you're following to kind of decide when is someone ready 8:13 for whether it's a peptide or a bio regulator. 8:16 Maybe you want to talk a little bit about which peptides and bio regulators 8:20 you do eventually 8:21 find to be helpful in these situations, but then we'll back up 8:24 and talk about what's this order of operations that you kind of follow. 8:27 And we know testing is at the top here, but what comes after that. 8:31 Right. Absolutely. 8:32 What I want doctors listening to understand and remember is 8:36 that peptides are signaling molecules. 8:38 I think doctors forget that because we're used to being in this mode 8:42 of using substances. 8:43 It could be medications, nutraceuticals, supplements. 8:47 We use them to either push a pathway or to suppress symptoms. 8:51 But we don't want to use peptides to do that. 8:53 They're actually not going to do that. 8:55 I think of peptides as the language 8:58 that cells use to speak to each other. 9:01 And so I want doctors listening to keep this in mind, 9:04 because that then informs the way that I put together to treat peptides 9:09 and by regulars for this particular patient population. 9:14 So the second thing I want doctors listening to understand 9:17 is that the clinical effects of these peptides 9:21 and the by regulators, it's going to be shaped by the terrain 9:25 that those peptides and viral land in. 9:28 So the first thing we have to do is consider men 9:31 a list of their entire system. 9:33 So I want to I want to consider gut integrity, mast cell stability, 9:38 inflammatory burden, autonomic regulation, mitochondrial state, 9:43 vascular function, hormonal adrenal balance. 9:47 Because these things, these areas are going to affect 9:50 the way the peptide behaves. 9:53 And so people with long Covid and Marcell activation syndrome, 9:57 they they often have well, they always have immune dysregulation 10:01 hyperactive immune system a weak immune system simultaneously hyperactive 10:06 because they have massive activation syndrome. 10:08 They have autoimmune and weak as they can't mount 10:10 the appropriate immune responses to kill the infections they want to. 10:14 It's a paradox, right? 10:15 Like paradox. And it's overactive. 10:17 And on the other hand, it's 10:18 not it's not doing its job, which I guess is where the term dysregulated comes in. 10:23 It's. Yes. 10:24 Yeah, absolutely. 10:25 And it's there that I want to start now. 10:28 They also have a dysfunction hormonal imbalances, 10:32 mitochondrial stresses, neuroinflammation, connective tissue issues. 10:36 They've got all of this going on. 10:38 And so I, I always wanted to start by modulating the immune system first. 10:45 Because when we kill infections or when we send 10:49 repair signals, they can be seen as a threat to patients who have 10:54 some trying to to take that sense of threat 10:58 down in the nervous system and in the immune system. 11:03 So I'm actually using peptides right away to treat mast cell activation. 11:09 Because remember, everybody listening, everything is a threat to these patients, 11:14 but not not substances that are going to calm mast cell activation syndrome. 11:18 So you really so so what are some of the things. 11:22 And because we also we have two populations listening to this right. 11:25 We have your potential patient and we have practitioners. 11:29 So for people who are listening what are some of the compounds 11:34 they might be able to tap into 11:37 to try and kind of calm and stabilize the mast cells, just to help them 11:42 to kind of get the brain power to find someone like you to work with. 11:46 Yeah, I love giving this information out because then people 11:50 can educate their doctors or doctors. 11:52 Listening can can now work 11:53 with their patients in that same way because I can't take everybody. 11:58 So so I love to spread this information. 12:01 So I used to always want to treat the immune system first. 12:05 Right. 12:05 And if I gave people my patients herbs first 12:09 say quercetin or luteal they would often or vitamin C, 12:14 they would often reject those herbs because there maybe because vitamin C 12:18 and Kirsten are supposed to stop a histamine reaction. 12:23 Right? Right. 12:24 But there are they are sensitive to the multiple chemical components of herbs 12:28 or of whatever else is in that vitamin C, whatever filler, 12:33 even though it's not a toxic filler, sometimes even the capsule. 12:37 So yeah. Right. 12:39 So the first thing I'm doing is actually healing leaky gut, 12:44 because antigens can escape 12:48 a leaky gut and go into circulation 12:51 and then trigger mast cells across the rest of the systems in the body. 12:56 So I'm using La Raza Tide now. 12:58 Sure, I could use Slippery Elm, I could use glucosamine
Using Peptides and Bioregulators in Sensitive Patients 13:03 because those help with leaky gut as well. 13:05 But there's been nothing more efficacious in my experience than La Raza Tide. 13:10 And sometimes I can add those herbs on after. 13:13 But I'm starting with lorazepam because I know my next step is 13:17 then mast cell activation syndrome and using Lexa Knox, 13:22 for example, that is a peptide that's a mast cell stabilizer. 13:25 It helps with allergic sinusitis. 13:29 It helps with insulin stability. 13:32 And these patients have all of those issues as well. 13:35 So I might bring La Raza on board first then I'm Lacs Knox. 13:40 So what's interesting about Alexa Knox just is this is a repurposed drug right 13:45 isn't it. 13:46 Like Knox wasn't it originally. 13:48 Was it a canker sore? 13:50 Yeah. Medication. 13:52 Yeah. Yeah it was. 13:53 And now it's all of a sudden it's this superhero in dealing with MCUs. 13:58 So really it really is. 14:00 And then I'm also using things like Finn 14:04 and Crumlin finding the appropriate appropriate dosage for the person. 14:07 Or maybe I might use Ax or sometimes I have to use Allegra 14:12 that will come from these drugs will come from the compounding pharmacy 14:15 because we don't want additives and fillers and dies. 14:18 It's going to reject all of that. 14:21 Now, I've been doing this this meaning treating mass 14:25 activation syndrome using peptides for the past ten years for my patients. 14:31 Prior to that, I was treating mass activation syndrome as well. 14:34 I didn't have I didn't have a Knox and have CFPB 14:38 and it was slower to treat. 14:42 So I might bring KPBS in a little bit later. 14:46 CFPB has wonderful mast cell stabilizing properties, but 14:49 it also has antimicrobial effects against Candida and some staff species. 14:54 And these patients are not ready for a kill of that 14:59 I guess I'm not ready for antimicrobial action yet. 15:01 They're going to be 15:03 to it. 15:04 Yeah I want to give you a patient story about CFPB actually. 15:07 So this patient is down to 5 or 6 foods. 15:11 And she had diarrhea for 20 years. 15:15 Been to multiple gastroenterologists multiple allopathic 15:21 and functional medicine doctors multiple nature paths over 20 years. 15:25 And she was diagnosed with Candida. 15:27 She's had all the work cuts, colonoscopies, everything biopsies. 15:32 The only diagnosis that came back was candida. 15:35 And she would have diarrhea eight times a day for 20 years. 15:38 What a way I know. 15:41 So I gave her DV and of course 15:44 she's not somebody who can tolerate an entire capsule. 15:48 So I said, all right, start with half a capsule. 15:51 Half a capsule was too much. 15:53 It gave her more diarrhea. 15:55 So I said, okay, not it's not that 15:58 this is the wrong medication for you're not the wrong peptide for you. 16:02 It's that I believe it's the right peptide, but just the wrong dosage. 16:07 So they're the CFPB. 16:09 I gave it to her to stabilize mast cells. 16:11 I gave it to her to kill some of that Candida in her gut. 16:14 Half a cat was too much. So we went down to toothpick tips. 16:17 By the time she got to, the third toothpick dip literally 16:20 opened the capsule, dip a toothpick and put in your mouth 16:23 the diarrhea had resolved. 16:25 Gone a toothpick dip. 16:27 Oh my. 323. Whatever. Any. 16:33 That's wild. 16:34 And so were you able to get this CFPB compounded for you 16:37 so that there were no fillers. 16:38 Because god forbid you're dipping your toothpick in the 16:41 in the filler part, not in the CFPB part. 16:44 You know it's just integrative peptides CFPB wow. 16:48 And okay yeah. 16:50 So it was enough to work. That's fantastic. 16:52 It was enough to work. 16:54 Yes it was amazing. 16:56 So I'll bring CFPB and also to stabilize the muscles. 17:00 Now once the mast cells are stabilized with those peptides leaky gut is healed. 17:04 And I also am going to bring in bio regulators because I want 17:08 you know, the thymus fire regulator is going to help stabilize 17:12 the immune system, the central nervous system, by a regulator. 17:16 I have given that to patients who have migraines, it's 17:18 taken away their migraines. 17:21 So this is really important. Right. 17:23 And the pineal bio regulator, it's going to help them 17:27 with their migraines as well as going to help calm 17:30 their hormones, regulate their hormones which are all in out of source as well. 17:34 So these are by regulators that are more stabilizing for the system. 17:39 I'm not giving them by regulars or peptides that that are asking 17:44 their systems to work harder, repair kill infections. 17:49 I'm I'm giving them ones that are calming, that are soothing. 17:53 Yeah. 17:54 Well and the bio regulators are particularly well suited to that. 17:56 Right. 17:57 Because typically they're not boosting anything. 18:00 They're they're trying the work of the bio regulators 18:03 to normalize, not so much to boost or suppress. 18:06 Right. 18:07 And I want to say another thing about the bio regulators, because we have 18:10 bio regulars for virtually every system of the body 18:14 I am, that offers me a new way to think about these patients, right? 18:20 Of course, I thought about the systems of the body, but I thought about it 18:23 based on the labs that I would see and based on a physical exam. 18:27 But now I can actually think, hey, what system needs healing? 18:32 What bio regular can I give to them to heal that system? 18:35 And for anyone who wonders if they work or not, they work. 18:40 They absolutely work. 18:41 I see I've witnessed them work over the past few years. 18:45 And clinician. 18:47 Yeah. Yes, that is so powerful. 18:49 Now, when you're talking about bio regulators, are you typically 18:52 using the natural oral bio regulators 18:55 or do you use the synthetic injectable bio regulators. 18:59 Or do you use a mix like what's your what's your feeling 19:04 on these different categories of bio regulators. 19:08 So what my patients have told me it mirrors what what I've read, 19:12 which is the synthetic ones to start with, 19:16 are actually going to be more tolerable to highly sensitive patients. 19:20 And then the more naturally derived ones, they're going to work faster. 19:24 And I don't want to give them things that are going to work too fast, 19:27 because that could be too fast for their systems to handle. 19:30 Yeah, I think the synthetic also is easier to dose titrate. 19:34 Yeah, right. 19:35 It's easier to pick a much slower a lower dose with I mean to begin with 19:41 we're talking about microgram dosages versus with the naturals. 19:45 You're looking at milligram dosages 19:47 and you're also getting lots of other stuff with it. 19:49 So yeah. 19:50 And I know that in the Russian literature they do 19:52 talk about the natural bar regulator. 19:54 They actually mentioned that it might be it might take a little longer 19:57 to see the effect of the natural, but it's it might be a bit longer lasting. 20:02 Right. 20:03 But I wonder if what you're seeing also is that they they react. 20:06 They may react more to the natural 20:08 because there's more than just that one amino acid chain in there. 20:12 So there's more things to respond to. 20:15 That's what I think is going on. 20:18 Yeah. 20:19 Yeah. 20:19 So the synthetics and again I mean you're, you know, it's it's this is I love it. 20:24 You know, you're interviewing someone and it matches up 20:27 with what you're learning and what you're reading. Right? 20:29 That I love with a very sensitive population, 20:32 the synthetic counterintuitively, the synthetic might be 20:36 an easier thing for them to tolerate than the than the natural form. 20:41 And they have to say, I have some vegan patients. 20:43 It's very hard to heal when people are vegan. 20:47 It's hard to get the diet right. 20:49 They don't have enough proteins in their system 20:50 or enough sulfur in their system to help with their detox pathways, 20:54 and don't have enough amino acids to help with their detox pathways. 20:59 And so I'm happy that the synthetic ones exist for the patients, 21:04 because I've seen people improve by leaps 21:07 and bounds with the synthetic ones. 21:10 Fantastic. Yeah. Okay. 21:13 So let's get back to our patients. 21:15 So what we started with was gut healing. 21:18 And maybe and it's interesting because a lot of people will hear healing 21:23 and they go straight to BPC. 21:24 157 you actually went straight to La Raza, which I think is really important 21:30 for people to hear because it is specific to ceiling those tight junctions. 21:36 BPC 157 has more broad ranging healing effects, but
Gut Healing, Detox Support, and Repair Peptides 21:39 raza tied really, really, really, really is. 21:42 It's almost like single mindedly which is unusual 21:45 for peptide goes to seal the tight junctions. 21:49 I'm so happy you noticed that and said 21:52 that because BPC 157 if not all of them, 50% of these patients, 21:58 if they take that first, they get jittery, 22:01 they get anxious, they feel wired so they can't sleep at night. 22:05 If they if they don't take it up, 22:07 you know, if they take it before 2 p.m., usually they're okay with it. 22:11 But that doesn't stop the jittery ness. And I had to. 22:14 Why would that be? 22:15 Well, I think it's because it's rapidly altering the gut brain axis. 22:19 It's increasing nitric oxide. 22:21 It's got these dopamine and vagal signaling. 22:24 And so until the mix is stabilized, 22:28 until the autonomic stabilized, until leaky gut is healed there, 22:33 these patients are going to perceive those signals from BP 22:35 157 as, as a threat. 22:39 Yeah. Too much of a challenge. 22:40 And so we said that we were going to talk about long Covid a little bit. 22:44 Where do you see 22:45 the overlap here with your MCA's patients and your long Covid patients? 22:49 Aside from the fact that maybe long Covid patients develop mixed, you know, do 22:54 I have yet to to meet a long Covid patient who does not have mix in my 23:01 right? 23:02 In my mind, there are two types of long Covid patients to two subcategories. 23:08 One category is they did well with the with the long Covid stacks they see 23:12 online, or they did well at Doctor Bruce Patterson's clinic or a long Covid clinic. 23:18 They did well at Stanford or Johns Hopkins with some LDN 23:23 with, you know, some some just a few treatments, maybe some. 23:28 God bless. 23:30 They did. 23:30 Well, these people have issues because of only 23:34 spike protein or the Covid virus itself. 23:38 Right. And they're easily treatable. 23:40 People who have issues that are larger than just the spike protein mediated 23:47 issues like persistent inflammation or micro clots, well, 23:53 they don't do well with the typical stacks or at the long Covid clinics 23:57 because other things happen to them in the process of getting long Covid. 24:02 So we know that spike protein wakes up dormant infections. 24:06 Somebody could have been tick and had Lyme 20 years ago and had no idea 24:11 because their immune system could keep it in check. 24:12 And they had Epstein-Barr virus 24:14 and mycoplasma immune system kept these microbes in check. 24:18 Along come spike protein and it wakes up these other infections. 24:21 So now they have a bunch of other chronic infections they didn't even know 24:25 they ever had. 24:28 They have reservoirs, maybe in multiple systems 24:31 of their body of spike or the virus itself. 24:36 They've got the micro clots and they have persistent inflammation 24:40 in every system of their body. 24:41 So now what do we do? 24:44 These are the people who fail the stacks. 24:46 So people might have read about this long Covid peptide by a regulator stack. 24:51 Right. 24:51 It starts with HL3 seven and is an alpha one. 24:55 And they're given the vascular by 24:58 bio regulator. 24:59 And then they're given the lung bio regulator. 25:01 Maybe they're given some micro clot support from the same. 25:05 Right. Yeah. 25:06 So so first of all, most of my patients when they've been given to 1 or 37 this 25:13 well they're taking it to treat chronic infections. 25:16 But when chronic infections are treated neurotoxins are released. 25:21 Bio toxins are released. 25:24 Our own immune system is going to respond with more inflammation. 25:28 But these patients are stuck in a loop of persistent inflammation. 25:32 So now when I start to kill chronic infections, 25:36 it's going to increase inflammation. 25:38 They're going to get sicker. 25:39 So I want I want the doctors listening or the patients listening to to understand. 25:44 We don't treat chronic infections the same way that we do acute infection. 25:49 If someone comes in and they have acute Covid, sure. 25:52 I'm going to start thinking about Paxlovid, right? 25:56 But if it's chronic, I can't treat 25:59 that infection the same way as though it's an acute infection. 26:03 I've got to calm the mast cells first. 26:05 Heal the key, got first work on the autonomic first. 26:09 And I can use peptides to do all of those things. 26:11 And by regulators 26:12 to do all of those things, as we talked about earlier, once that set, 26:16 then I can come in and start to use HL3 seven and thymus and alpha one. 26:22 Now the vascular bio regulator, 26:26 some patients, they take it and then right after they take it 26:31 they get hemorrhoids or they get migraines. 26:34 That's crazy. 26:36 Yeah. 26:36 So if anyone does, layers don't work. 26:38 Excuse me. 26:39 They're working. 26:40 Okay. Clearly it's working. 26:43 So what's causing that? 26:44 Because we don't 26:45 you know, we typically say very, very few if any side effects ever. 26:49 But this is a very special population. 26:51 Very. 26:53 So tell us about this. Yeah. Yeah. 26:55 So the buyer regulators they're going to increase endothelial signaling. 26:59 They're going to increase nitric oxide. 27:01 They're going to improve circulation. 27:02 It's going to change capillary perfusion. 27:05 So all these good things the blood vessel by regulator does right. 27:09 And so for the people who didn't have problems with MCA's 27:14 or lymphatic flow or constipation 27:18 or not having enough cofactors for detoxification, this works beautifully. 27:22 But if if you have MCA's 27:26 lymphatic issues, decent anomia, 27:29 all of these beautiful signals from that bio regulator could be seen as a threat. 27:34 And will we stabilize all these things? 27:36 So we have to stabilize MCAS, stabilize the autonomic, 27:41 and also support the detox pathways of these patients before we can even start 27:46 to consider giving them the blood vessel by a regulator 27:50 to 1 or 37. 27:53 Yeah. Yeah. That's that's so incredible. 27:55 So the classic bio regulators just so classic peptides. 28:01 Sorry. 28:01 So because I think, you know the bio regulators as you said 28:05 I mean you you weave them through like for central nervous system 28:09 support for immune support for blood vessel support the pineal gland for this. 28:14 But the main the big hitters here on MCA's and long Covid 28:18 probably are also going to come mostly from the signaling peptide population. 28:23 Right? Yes. Right. 28:25 So and I just want to recap a bit for people because we're supposed 28:29 to keep these, you know, this is this should be like a two hour interview. 28:33 We're going to keep it under 45 minutes. 28:35 But I just want to recap that the first order of operations 28:39 very often is stabilizing and sealing the gut. 28:42 So we're starting with tide. 28:45 We might add a little bit of CFPB in there to help to reduce inflammation. 28:50 But it's going to 28:50 have to be only teeny tiny because of those antimicrobial effects. 28:54 You talked about a repurposed drug like I'm Lexa Knox. 28:57 That can be very helpful early in the game. 29:00 What about things like like phospholipids like to help with the cell membrane. 29:05 Like like something like a PC oil for example with the. 29:10 Yeah, 29:11 that comes in after I've supported their detox pathway. 29:14 So I'm looking at their their cofactors of detoxification, 29:19 their minerals, their B vitamins, their amino acids. 29:22 I'm looking at their genes, I'm looking at their detox 29:26 pathways, their inflammatory pathways.
Long COVID, Chronic Infections, and Treatment Sequencing 29:29 I also want to understand if they're in a state of oxidative stress, 29:33 if their glutathione is in a state of oxidative stress. 29:37 So I'm looking at all of these things. 29:39 And very often 29:40 I want to give them phospholipids or I want to give them 29:43 phospholipids intravenously because that can help so much. 29:47 But when we do that, we start to then elicit a detoxification response. 29:52 Then we can mobilize the toxins that were fat soluble 29:56 and recirculate them if their detox pathways are not supported. 30:01 We've got to bolster that first. 30:02 So from all those labs I'm looking at, plus their genetics, I'm deciding, okay, 30:07 are you ready for that? 30:08 Phosphatidylcholine or not yet. 30:11 Are you ready for glutathione or not yet? 30:13 If I give them glutathione right now, usually glutathione. 30:16 Phosphatidylcholine are given together, particularly intravenously, 30:19 not in the same bed, but right after one another to help with detox. 30:23 If the glutathione is in a state of oxidative stress, 30:26 I could give them more glutathione, but they're just going to their 30:29 system is going to whip that back up into more oxidative stress. 30:33 So I love to use the peptides and the by regulators to help with that 30:38 oxidative stress. 30:39 Actually, I might use bring in TB for 30:42 at that point I might bring in BPC 157. 30:46 At that point. 30:47 GHQ can help with that as well. 30:50 But we have to remember that these are the repair peptides. 30:53 And again they can be seen as a threat. 30:56 So we have to bring those in after we've come. 30:59 The mast cells. 31:00 Yeah. 31:00 Also with TB 31:01 for one of there's one of the fragments actually will destabilize mast cells. 31:06 Right. 31:06 And so I know this from sad personal experience. 31:11 And you know, you end up sitting there going what? 31:13 What? No. Everybody says this is so amazing. 31:16 How is this creating lumps in my body and and a rash and a this and that. 31:21 And so I think again, 31:23 this is another highlight that we really need to underline for people listening 31:27 who may be dealing with MCUs, they may be new to the space. 31:31 Understanding that thymus and beta four as part of its healing process 31:37 can destabilize mast cells, which is fine in a healthy person, but 31:41 actually will be a problem for those of us 31:43 who have mast cells that are maybe a little too reactive. 31:47 Yes, absolutely. 31:48 And how could I forget to bring in GLP one agonists? 31:53 Low, low dosages of them can absolutely help with Marcel. 31:59 Activation syndrome can help bring down in inflammatory response. 32:04 They can cross the blood 32:05 brain barrier and bring inflammation down in the brain as well. 32:09 Oh, by the way, of course I'm also using Cmax and Clank. 32:13 I can use those pretty early on if I'm using 32:17 the injectables, the nasal sprays. 32:20 A lot of things have colonization in their sinuses. 32:23 So even though the nasal sprays 32:24 are are easier to use than the injectables are a little more pleasant. 32:28 If you've got mold in there or bacteria in there, you don't want a bio film. 32:33 The nasal sprays aren't going to work so well. 32:35 So all right, Pro tip guys. 32:38 All right. 32:39 And I don't I want to back up to the GLP. 32:41 Your mention of JLP. 32:43 This is where that microdosing really really could be helpful. 32:48 And can we define please. 32:50 What is a micro dose. 32:51 Because a lot of people are walking around thinking a starting dose 32:54 as a micro dose or half a starting doses of micro dose. 32:57 And my understanding 32:59 from you and other physicians in this space is that a micro dose is micro. 33:03 Are we talking a 10th, a 20th, a pinprick, like what are we talking for? 33:08 Micro. 33:09 So for me, I know we just made that definition of right. 33:12 Here's a micro dose. 33:13 Well typical micro dose that I'll start with my patients is a tense. 33:18 Some people who are very sensitive. 33:19 It could be a 20th of a starting dose of a starting dose. 33:25 Now some people I just don't want them to lose any more weight. 33:29 And so those that I'm really just going to start with at a 20th 33:33 and then go on slowly increasing as tolerated. 33:39 And usually they never go up to a full dose. 33:41 They don't need to but they don't need to. 33:43 So and so just to recap again, in this case 33:47 the P is not there for fat loss. 33:51 It's not there to reduce appetite. 33:53 It's not there for any of the to reduce cravings. 33:56 It's really there. 33:58 Like tell us a little bit 33:59 about what are the benefits you're seeing for your patient population 34:03 with this tiny amount of this very powerful compound. 34:07 Right. 34:07 People are telling me my vibrations under my vibrations under my skin are gone. 34:13 I used to think that sounds like Bartonella. 34:15 Bartonella will do that, right? 34:17 But give them a little bit of g g 34:20 I almost a GHQ because GHQ will do that as well. 34:24 So do what it'll cause vibrations or it'll help with the vibration, 34:28 help with the vibrations. 34:29 It'll help with the neuropathies. 34:30 So I've seen that GHQ and low doses of GLP one. 34:34 Agnes, those two together will help with neuropathy. 34:38 That is amazing right? 34:40 Like until the advent of peptides these patients had to suffer 34:45 through neuropathy sensations until we killed all of their microbes. 34:51 But now, with the advent of peptides and bio regulators, 34:54 we can be more sophisticated in the way that we treat these patients. 34:58 We can stabilize them, calm their immune systems, and get them ready 35:02 to kill all those bugs that we, I think eventually do need to kill. 35:06 Yeah, I've got a story about 37. So 35:12 here's 35:13 the patient who had an invasive syndrome. 35:16 Two so she had Aspergillus type of a mold in her lungs. 35:20 So you'd be okay throughout the year. 35:23 Then came allergy season. 35:25 She had more activation syndrome. 35:27 So allergy season for her was just the worst possible. 35:31 And and during allergy season her 35:35 the aspergillus in her lungs would bloom. 35:38 So she'd been to pulmonologists. 35:42 She'd been to entice again functional medicine 35:46 regular doctors, users given steroids. 35:49 You're just going to have to live with this. 35:51 And here are some steroids and and take some histamine 35:56 blockers and allergy season. 35:57 And that's the best we can do. Right. 35:59 And it was tested and you could test it. 36:01 It was tested in her sputum. 36:03 So she comes to me and I say, all right we're going to do this. 36:07 We're going to calm your mast cells first. 36:09 And it's going to be so that during allergy season, it's 36:13 not going to be it's not going to take your whole life down 36:17 because allergy season. 36:18 So everything I talked about I wasn't using the GLP one agonist yet. 36:23 It was this was probably five years ago. 36:25 And so I'm like Laura's Tide CBV. 36:31 She was on BBC 157 and stabilizing her muscles, adding BPC at the right time. 36:38 She was also taking Finn and Crommelin and other 36:41 histamine blockers, so she needed a well, everybody who needs 36:45 who is being treated by who's treated for a well-rounded protocol 36:49 using many different methods, right, to to treat this at the same time. 36:54 So Marcel's are stabilized. 36:56 Now I say, okay, let's bring in some thymus and Alpha one. 37:02 It's time 37:03 to start killing these chronic infections. 37:06 So low dosages just twice a week. 37:09 Okay, now it's time to bring in some 37. 37:13 Again, low dosages just two times a week, three times a week. 37:17 And allergy season came. 37:20 No Aspergillus in her lungs. 37:22 She did a sputum test. 37:24 It was gone. 37:25 That is the power of the right. 37:28 And so were you. 37:30 Was she nebulizer it or was she actually injecting it? 37:33 Injecting it? Wow. That's interesting. 37:36 That's crazy because Ella, 37, definitely is a double edged sword. 37:40 You meet people all the time who went to high to fast with L 37 37:44 and ended up like in bed for three days or something. 37:47 Horrible. 37:48 Yes. So careful 37:49 because it's perforating the cell walls of a broad spectrum of microbes. 37:53 So that means you're killing multiple different microbes at the same time. 37:57 You have to be careful. 37:57 But not only that, if someone has a propensity to Soria 38:01 arthritis, and I believe 38:02 probably any other autoimmune condition, it can potentiate that. Wow. 38:06 So we have to be so careful.
Microdosing, Safety, and Clinical Outcomes 38:10 This is an art. 38:12 It is right. 38:13 I mean, you need to understand the science so that you can apply the art and that. 38:17 And that's where all your years of experience really come in. 38:21 You know, when you've seen when you and I mean, you've never seen it all, 38:25 but when you've seen so much that it gives you a broader toolkit. Yes. 38:30 You know, I use the word dangerous. 38:31 It's not I don't want anyone to 38:33 think this is going to kill you if you take a normal dosage. 38:37 It's not dangerous in that sense. Right? 38:40 It's just like a small s danger, like, okay, you might be in bed. 38:44 You're you're psoriasis. 38:45 What's known that. Yeah. 38:47 That that reversible hopefully. Yeah. 38:51 Although I've seen people respond badly to BPC 157 and I suspect there 38:56 in this population and it can last for quite a while. It. 39:00 Yeah there are 39:01 there was back in the day when I had my Facebook community, 39:03 there were other Facebook communities that were only made up of people 39:07 who'd had negative reactions to BPC 157, and they were the most baffled 39:11 of the people using peptides because they were like, okay, 39:14 everybody says it's it balances the dopamine, serotonin and Gaba systems. 39:20 I become homicidal when I use this stuff. 39:23 What's going on? 39:24 Or they or they have anhedonia where they just didn't care about anything anymore. 39:28 Or like you said, they'd be anxious or agitated. 39:31 One guy was like, if I bring out the BPC, my dog goes hides on the bed. 39:35 Like, you know, it was it's really interesting. 39:39 But now what? 39:40 You're what's coming out 39:41 now from physicians like you is the understanding that 39:44 in these populations of people that are hypersensitive, 39:47 whose systems are just hypervigilant and just waiting for an excuse, 39:53 these types of compounds that can be really great 39:55 become a negative if they're not used in the right place at the right time. 40:00 Yeah, right. 40:01 What I want to be clear to everybody listening is that this is with anything. 40:04 Okay. It's not that. 40:05 Oh peptides and via regulators are dangerous. 40:08 It's that when we're dealing with this patient population, everything, 40:12 everything we do must be 40:13 thought out with such detail and really felt into intuitively. 40:18 At the same time, there's got to be a mix of science and intuition, 40:23 knowing that the same thing can happen if you give a patient 40:26 a medication or an herb or a nutraceutical. 40:30 Today I'm talking about with peptides and by irregulars. Why? 40:33 Because I'm so excited by them. 40:34 Because over the past ten years I have seen no other substances 40:38 work to heal these patients as quickly. 40:41 So patients whom it would have taken five years for me to treat 40:45 now two years with the advent of peptides and bio regulators. 40:48 That's why I'm so excited about them. 40:51 But the pitfalls of using them 40:54 will be the same as the pitfalls of using anything else. 40:58 When you're dealing with the highly sensitive patient load. 41:01 Love it doctor papaya, as always a pleasure. 41:05 We're going to have to stop here. 41:07 And I know everybody's screaming at me going, what do you mean you have to stop? 41:11 Keep going. 41:12 We will, we'll do we'll do another podcast together. 41:15 Have. No. 41:16 We did do a podcast together. 41:17 You can go look for that episode as well. 41:20 But for now we're going to have to leave it at that with doctor. 41:24 So for everybody listening here, where do they find you?
Where to Find Dr. Parpia and Closing Remarks 41:28 How do they learn more? 41:29 Do you have a website, a newsletter, an Instagram account? 41:32 Tell us. Yes. 41:34 They find us at GordonMedical.com. 41:37 That's our website. 41:38 We have patients to patients coming from all over the country, 41:41 all over the world to our clinic for these mystery cases. 41:45 We have the Gordon Medical Forum scored in medical. 41:48 That's where we do our forums and our podcasts and our Instagram. 41:53 We haven't paid enough attention to Instagram. 41:55 We're kind of starting to now. You're fine. 41:57 You've got lots of other things going on. 41:59 And yes, your podcast, please tell us the name of the podcast. 42:02 Yeah, it's simply the Gordon Medical Forum. 42:05 Smart. 42:06 And you are on my podcast I am I know we did. Yes. 42:10 Thank you so much for your time today. 42:12 Thank you for sharing your wisdom and I look forward to speaking again soon. 42:16 Thank you. Thank you so much.
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