Full Transcript Introduction to menopause genetics 0:00 Welcome back to Menopause Mastery. I 0:01 want you to picture, you know, maybe you 0:04 in your 40s or maybe another woman in 0:07 her 40s. And on paper, everything looks 0:10 absolutely correct. Everything's right. 0:12 She's eating a whole food. She's eating 0:14 a clean diet. She's lifting weights 0:16 three days a week, prioritizing her 0:18 sleep, and tracking her recovery. But 0:20 over the last 18 months, her body feels 0:22 like it's operating under a completely 0:25 different plan. and she's going through 0:27 all of the pmenopause and menopausal 0:29 symptoms. And when she goes to her 0:31 doctor, everybody says, "Hey, you know, 0:33 you look completely normal." It's part 0:34 of the transitional myth. And for years, 0:37 when women have wanted to dig deeper, 0:39 they turn to a lot of different kind of 0:41 testing. And many of them turned to 0:44 generic direct to consumer DNA testing. 0:47 And maybe you've done one. Maybe you're 0:49 like me and you've done a bunch and you 0:51 spit in a tube, you send it off and you 0:53 get it back and you get either a 50-page 0:55 report with single genes and single 0:58 answers and it all looks like a bunch of 1:00 gobbledygook and it doesn't actually get 1:02 you closer to what your understanding is 1:04 of your body. Or you pay exorbitant fees 1:06 for 10 genetic snips that doesn't really 1:10 give you a lot of answers and is so so 1:12 narrow in its focus that it's actually 1:14 missing the point. And so what I'm here 1:16 to talk about today with Dr. a Tracy 1:18 study of the DNA company is how to look 1:22 at your genetics and how to have a 1:24 genetics test that actually makes a 1:26 difference. The DNA company created a 1:29 test that actually has what we call a 1:31 polygenic score, which is these genes in 1:34 action in a group and in combination. 1:36 And Dr. Steady is an expert in this 1:38 arena and functional genomics. She's 1:40 also an expert in acupuncture and 1:42 Chinese medicine with over two decades 1:44 of experience helping women navigate 1:47 pmenopause and menopause using those 1:50 techniques along with functional 1:52 genomics to be able to personalize their 1:54 diet lifestyle nutrition plans. And so 1:57 today, we're going to get rid of some of 1:58 those myths about estrogen 2:00 detoxification, even the MTHFR gene, and 2:03 how to actually look at a polygenic 2:05 MTHFR gene, and how to dig through this 2:08 information and understand how these 2:10 different genetic areas like 2:12 cardiovascular risk, mood, exercise, and 2:15 recovery, detoxification, all go 2:18 together so you can make better 2:19 decisions. So, join me today on 2:21 Menopause Mastery. 2:24 Dr. steady. You know, genetics has been 2:27 really popular for quite a while. I 2:29 would say probably 15 years, you know, 2:31 15 16 years ago was the first time like 2:33 genetics became commercially available. 2:36 You know, whether it's 23 and me and you 2:38 know, all the multitude of different 2:39 companies. I think I started doing 2:41 genetics when like pathway genomics came 2:43 out or whoever it was. I think the first 2:45 one. What brought you to genetics? You 2:48 know, from your background, I have 2:51 always found it a little bit 2:52 interesting. I remember the first time I 2:53 heard about dopamine receptors and DRD2 2:56 was in grad school. So I was looking 2:58 back through my notes and I think that 2:59 was 2005 or something like that that I 3:02 was like, "Wow, you can tell so much 3:03 about genes." But what what brought me 3:05 to it this round was that there was 3:08 something going on with my immune system 3:10 and I couldn't figure it out. And I 3:12 couldn't figure out if there was a 3:13 hormonal component because of my time of 3:15 life or if it was just chronic Lyme 3:16 disease or what was going on that I just 3:19 couldn't seem to fully heal. So, I 3:22 decided to do the testing and I thought 3:24 the information was so interesting and 3:26 cool that then I became a certified 3:28 functional genomics practitioner. 3:31 Oh, that's awesome. That's awesome. 3:32 Yeah, I think it's um you know, I was 3:34 always very interested in it all the way 3:36 back multiple times in school, you know, 3:39 and I I think early on when they started 3:41 the human genome project, I was hoping 3:43 that it would be very deter like anybody 3:45 else, you're like, "Oh, we're going to 3:46 find all the light switches and you 3:48 know, each one's going to have an 3:49 individual thing. So, we're going to 3:50 find the answer to human life, right? 3:52 And all the things that go wrong with 3:54 us. And I and I think that, you know, 3:56 once we got deeper into the data and it 3:58 was like, wait, we don't really have 4:00 that many genes and they aren't single 4:02 in nature and that it's these all these 4:05 pathways. And so, to some degree, it's 4:07 by far more complicated 4:10 and also not at the same time because 4:12 most of our genetics are shared, you You 4:14 know, so if you look at the span of 4:15 humans, like 99% of our entire genome is 4:18 the same. And you know, we share about 4:20 95% of that with a frog, 4:22 right? You know, it's like, wait, you 4:25 know, but but I think I think, you know, 4:27 the first thing that I'd love to get out 4:29 of the way is, you know, the idea of 4:31 genetics testing because there's so many 4:33 companies out there and there's, you 4:35 know, I think a lot of subtifuge out 4:36 there. I think there's a lot of 4:37 primarily just because there's 4:39 a lot of people just selling these very 4:41 very limited sort of you know gene kits 4:44 that have like 10 genes are like this is
Why polygenic testing beats single-gene reports 4:46 the only thing you need right this is it 4:48 this is all it answers all the questions 4:51 and you know h how do you look at that 4:53 genetics kind of environment and 4:55 especially kind of talking specifically 4:57 about the DNA 360 and how that is very 5:00 very different than most of the 5:02 available tests that people probably 5:04 have already done. 5:06 What I really love about it is it's 5:08 polygenic. So, we're not just taking one 5:10 snip or one gene into consideration when 5:13 we're making an assessment of someone's 5:15 tendencies, right? And also, we're 5:18 looking at at the whole pathway. So, for 5:20 so, let's say methylation is my favorite 5:22 example because a lot of people will 5:25 just say something about MTHFR, right? 5:28 And that's it. And that's as far as the 5:30 story goes. And then they're shoving 5:32 methylated vitamins down people's 5:34 throats like their candy and it's a B 5:36 vitamin so it's water soluble. You'll 5:38 feel fine. And then you have some people 5:40 who are not feeling so great as a result 5:42 of that because the rest of their 5:43 methylation cycle can't support the 5:46 level of methylation that someone is 5:48 doing. And so, you know, we're really 5:50 trying to look at the whole person and 5:52 we're doing it by looking at how the 5:54 genes interact with one another and 5:56 really more like a a family or a recipe. 5:58 here's how all of these spices work 6:00 together to create this flavor. And 6:02 that's what the assessments are more. 6:04 It's not deterministic. It's not saying 6:06 we're assessing that you will end up 6:09 here. It's more like here's the flavor 6:11 of your genes and here's how you can 6:14 change that flavor. Add some lemon 6:15 juice, right? Like if you put too much 6:17 salt in it. So that's really that's one 6:19 of my favorite things about it. It's 170 6:21 different data points that we're looking 6:23 at, but it's really how they're put 6:25 together that's so special. 6:27 >> Yeah. And I think I think that's so very 6:29 important. Like you brought up MTHFR and 6:31 I and I literally know a gentleman. His 6:33 name's Teodoro Botaglier and he just got 6:36 another new role, but he was at at the 6:39 Baylor system for a very long time here 6:41 in Dallas. And he was one of the first 6:43 researchers actually isolating MTHFR 30 6:46 years ago, like 30 years ago. And and 6:49 looking at it, whether it was 6:51 reproductive health or everything else. 6:53 And you know and and the idea that a 6:56 singular gene acts in its in its 6:58 exclusion to everything else is number 7:00 one never could be possibly how the body 7:02 works. But I think it you know in many 7:04 cases brings on adverse events. And I 7:07 think the methylation gene is the 7:08 perfect example of that that you know 7:11 one one person with a particular 7:13 polygenic score can't even handle 7:16 methylated folate more or less 7:18 methylated cabalamin despite possibly 7:21 having genetic mutations there because 7:22 of the other ones in the in the family 7:24 further either further up the pathway or 7:26 further down and you know and I think 7:29 that in today's far you know basically 7:31 pharmarmacological 7:33 dosing of vitamins especially you know I 7:36 run into people and they're like, "Well, 7:37 my, you know, my practitioner told me I 7:39 needed, you know, 15 milligrams of 7:43 methylolate." And I'm like, "Never 7:44 possibly in human existence could we 7:47 possibly consume that much folate. 7:50 That's tens of thousands more than what 7:52 somebody needs." And it's it is scary 7:54 because I think people are taking these 7:56 super physiological doses based on a 7:58 single gene or you know one or two 8:00 things that they picked up about 8:02 genetics assuming that it's going to be 8:03 great when they're kind of overstepping 8:06 what could possibly happen in nature. 8:08 Yeah. The the other place that I see 8:10 this happening is with DIM, 8:13 >> which is that a lot of people if they 8:15 hear that they have more of a tendency 8:18 to metabolize estrogen in a certain way, 8:20 they might be taking 250 to 500 8:24 milligrams of DIM a day while they're 8:25 doing BHRT and they're wondering why 8:27 their symptoms aren't resolving. And 8:29 it's it's it's that's not the whole 8:31 picture. Even if someone does have a 8:33 tendency in that direction, and even if 8:36 maybe a little bit of DIM isn't a 8:38 terrible idea, dim might be too strong, 8:41 you may be better off eating broccoli 8:44 sprouts or doing sulforophane or any 8:46 number of other things, right? It's it's 8:48 not there isn't a one gene, one answer 8:52 thing out there in the way that we're 8:54 working with functional genomics. So, 8:55 this is different than um if it's a 8:57 chromosomeal thing or or something like 8:59 that. Obviously, there are genetics that 9:01 it is deterministic, right? But that's 9:03 not what we're talking about when we're 9:05 talking about functional genomics and 9:06 there there just isn't that onetoone 9:08 correlation of thing. 9:09 >> Yeah. You know what? We should probably 9:11 back up because I know a lot of my 9:13 listeners are probably very familiar 9:14 with genetics, but we might have some 9:15 new miss listeners. So, let's talk a 9:17 little bit about what's the difference 9:19 between, you know, like chromosomeal 9:21 errors, genetic genetic diseases, 9:24 genetic cancers, and then what we're 9:26 talking about when we're talking about 9:27 functional genomics. So certain things, 9:30 you know, I don't want to get into a 9:31 whole genetics lesson, but some things. 9:35 >> So if obviously if someone has a 9:37 chromosomeal thing happening, that's at 9:39 at a different scale than a SIP and that 9:42 is and and they are going to um have 9:45 certain characteristics and certain 9:47 things that are associated with a change 9:49 in their in their DNA like that, right? 9:52 And there's if you test for that, that's 9:54 how it's going to show up. And granted, 9:56 there can be differences in presentation 9:57 there, but it's it's it there it's going 10:01 to happen, right? And with um with some 10:03 of the testings for cancer, it's it's 10:05 it's about likelihood. You have this 10:07 percentage higher risk of this type of 10:10 cancer if you carry this type of gene 10:13 mutation. And even that some people who 10:15 for instance who carry the BA gene don't 10:17 end up with breast cancer and some 10:19 people who don't end up with breast 10:20 cancer. So once again, that there's a 10:23 little bit more wiggle room, but it's 10:24 important testing because people want to 10:26 know how to take care of themselves and 10:28 how to screen and how frequently, right? 10:31 So it it changes how we go about taking 10:34 charge of our health, right? And then 10:36 there's functional genomics and that's 10:38 basically the premise that these are 10:40 your tendencies and here are the 10:42 lifestyle levers that you can pull in 10:44 order to make your tendencies work for 10:48 you instead of against you. because 10:50 we're living in a world that is so 10:53 different from what our ancestors were 10:55 dealing with, right? So, all of these 10:57 things were really important back when 10:59 they developed and were passed on. Uh 11:01 but we're we're living in a different 11:03 time. And so, some of the useful things 11:05 are we don't know what they were because 11:07 we're not living in that time anymore. 11:09 and some of the other things that have 11:10 come into existence since then like air 11:13 pollution and water pollution and 11:15 pesticides and all of these things. 11:17 Plastics weren't really a part of of the 11:19 picture back then. So, our bodies have 11:22 to be treated differently. And knowing 11:25 what our bodies tend to do lets us know 11:27 which levers are most important to pull, 11:30 how to pull them properly, and how not 11:32 to make, I don't want to say errors, but 11:34 how how not to make the decision about, 11:37 you know, taking 15 g of folate when 11:41 that's not what your body wants because 11:43 we also have this opportunity to use
MTHFR, methylation, and supplement overuse 11:46 supplements and and lifestyle to to help 11:49 ourselves. So, we want to make sure 11:50 we're walking in the direction that is 11:52 going to help our body the most. 11:54 >> Yeah. I think it's, you know, because a 11:56 lot of times people perceive these any 11:58 kind of mutation, right? And there's not 12:00 a single human on the planet that 12:01 doesn't have some, right? Just period. 12:04 They think of it as I got the bad gene. 12:06 I'm going to air quote bad gene. But we 12:08 have to remember our ancestors, whether 12:10 we're from the Philippines or we're from 12:13 northern, you know, Europe or we're from 12:15 subsahara Africa, our environments, our 12:18 foods, our environments, our weather 12:21 experience, all of those things were 12:22 radically different. Our exposure to 12:24 sunlight, the only reason why people 12:26 have lighter skin is they had shorter 12:28 times of period exposure to sunlight. 12:30 So, our melanin production was actually 12:32 less. Period. Full stop. But because of 12:36 that, you know, somebody that has darker 12:38 skin has the ability to make vitamin D 12:40 and synthesize it at a much different 12:41 level, different vitamin D receptor 12:43 activity. All of those things that our 12:47 ancestors needed in order to make it 12:49 here and it was good until our 12:51 environment became what it is today, you 12:53 know, in many many cases. And I think 12:55 that's so so important because it's it's 12:58 not the harbinger of doom. It's just, 13:00 hey, don't live your life like you're 13:03 Keith Richards when you're not and you 13:04 don't have those genes. He's the guy I 13:06 pick on. I swear to God, somebody 13:08 introduced me to Keith Richards because 13:09 I'm always like, he must have the most 13:11 amazing genetics, 13:12 >> right, 13:13 >> for partying. Like, he's got to have 13:14 like every liver pathway just is like 13:16 rock solid, 13:18 >> you know? Absolutely. Partied harder 13:20 than most people could ever imagine is 13:22 still rocking and rolling. I'm like, I 13:23 pray that I might be that way, but I I 13:25 already don't have the tolerance for it, 13:26 so I know that's not true. 13:28 >> Yeah. You and me both, sister. I'm no 13:30 Keith Richards either. [laughter] So, 13:32 >> yes, 13:33 >> but but if you know that you're not, 13:35 then you don't live like you are and 13:38 then have regrets about that later, 13:40 right? If if you know, that's one of the 13:41 things. If you know certain detox 13:43 pathways are not super strong, you can 13:46 you can take care of yourself better. 13:48 You know, if you know that you're going 13:49 to you are more likely genetically 13:51 speaking to develop a an adverse effect 13:55 from a statin, then you may there may be 13:59 some other kind of medication and you 14:01 can talk to your physician about that if 14:02 you're suffering from high cholesterol. 14:04 And you know, some of the genes in our 14:06 in the cardiovascular panel are really 14:08 helpful in that way. Lipoprotein A 14:10 genes, someone who is suboptimal in 14:12 those, it it doesn't mean that that 14:15 anything terrible is going to happen to 14:16 them. which just means you might want to 14:18 get screened a little bit younger for 14:20 certain cardiovascular things. Get your 14:22 lipoprotein A tested, maybe do a calcium 14:25 cardiac score a little earlier than 14:27 someone else, especially if you have a 14:29 history in your family of cardiovascular 14:32 events. Right. So, it's empowering. It's 14:34 like what what can I do with the 14:36 information about myself? 14:38 >> Right. Right. Yeah. Like I I mean I was 14:40 very fascinated I would say on the other 14:42 side of that because I'm adopted. I have 14:43 no ability to look into my family 14:46 because they're not genetically the same 14:48 and say what is my overall risk pattern 14:50 going to look like, you know, and you 14:53 know, and so that that's what drove my 14:55 interest because I was like, I have no 14:57 idea so I can at least find out and make 14:59 those changes. But I I would say even 15:01 more so if you have heart attack or 15:03 stroke history in your family, it's time 15:05 to d buckle down and understand your 15:07 genetics potentially for cardiovascular 15:10 disease for sure. Like that's a that's 15:12 one that you have a lot of agency. I 15:14 mean there's many, but you have a lot of 15:15 agency over it as long as you understand 15:18 it and know what to do. And I think a 15:20 lot of people either take one view where 15:22 they're like, "Forget it. I don't want 15:23 to know." Or I I'm I'm going to have 15:25 this cuz my family had it. And that's 15:27 not true either. And I think that's 15:29 where people need to understand the 15:30 power of yes, you might have it in your 15:33 history, but was was it because your 15:34 family smoked? Like my dad was a smoker. 15:36 he was going to have cardiovascular 15:38 disease, you know, because when you 15:39 smoke like that, it's like breathing car 15:41 exhaust like all day every day. You're 15:44 going to destroy your arteries. But, you 15:46 know, now that we've had like a large 15:48 amount of population that aren't doing 15:49 some of those things that we know are 15:51 fully damaging, we're starting to see 15:53 where those genetics are probably 15:54 playing out in a much greater way than 15:57 when everybody smoked, including your 15:58 doctor. Well, and that's where make 15:59 linking up some of the things about the 16:01 genes because when people talk about 16:03 APOE, a lot of times I think they see 16:06 that more like a sentence of some kind 16:09 for something and instead looking at the 16:11 interplay, how does it how does it 16:13 interact with your inflammatory tone? 16:16 How does it interact with your 16:18 cardiovascular profile with things like 16:20 lipoprotein A, with how you respond to 16:22 inflammation, with what you're likely to 16:25 respond in terms of nitric oxide 16:27 production and hypertension and all of 16:30 those things together and blood sugar 16:32 regulation. I mean, we have the 16:34 metabolic panel and the insul insulin 16:37 resistance panel. That's that's once 16:39 again really important information. I I 16:42 knew from experience that I didn't do 16:44 great with starches. Sure enough, I've 16:47 got all the worst genes for 16:49 carbohydrates that you can have and 16:51 saturated fat. So, lucky me. You too. 16:54 I'm double on all of those. And I I 16:57 remember I remember years ago when I 16:58 first did my DNA co and I was laughing. 17:01 I said, I've always said that I needed 17:02 to eat air because I was like, if it's 17:04 carbs, straight to my ass. If it's if 17:05 it's if it's that straight to my I was 17:08 just like, no matter what I do. But you 17:10 know what it is? I look at that. You 17:11 want to know why that allowed me to 17:13 survive some really cold winters in my 17:15 family, my ancestors in Ireland.
Chromosomal disorders vs functional genomics 17:18 Probably made it through the potato 17:19 famine just fine because we could hold 17:21 on to some extra body fat. You know, 17:22 there's a reason, right? Absolutely. 17:26 Absolutely. And now we don't we don't 17:27 need that. So, we just have to, you 17:30 know, live a little bit differently in 17:32 order to not have our bodies think that 17:34 we're suffering again from something. 17:36 Because that's the other thing that I 17:37 see with people is that then they might 17:38 overcompensate and not eat enough of 17:41 anything or nothing with fiber or you 17:44 know there are all of these things that 17:45 people are doing that I think really I 17:48 was you know so I was doing keto for a 17:50 while when I was for first in perry 17:51 menopause and then I got my gene report 17:54 and I was like oops maybe with my 17:56 cardiovascular report doing keto isn't 17:58 such a good idea and it's also more 18:00 likely to make me gain weight. So that 18:02 was just an interesting thing for me to 18:04 note during that time which was such a 18:08 turbulent time. Early pmenopause for me 18:10 was really really rocky. 18:12 >> Yeah. Mine is 18:14 >> Yeah. And so I was just looking for any 18:16 kind of answers that I could get. And 18:18 learning how my body metabolized 18:20 estrogen, learning how my body wanted to 18:23 eat. These were big big things for me at 18:26 that particular time because 18:28 >> I was just trying all the fad things 18:30 even though I'm a practitioner. You get 18:33 desperate. You're like 18:34 >> I am out of control. I need to take 18:37 charge of this. I'm going to try 18:38 anything at this point. And really I 18:40 just wish I had done the genetics test 18:41 sooner. 18:42 >> You said that because you know a number 18:44 one I think there's a prevailing wisdom 18:46 that if somebody's a practitioner 18:48 nothing ever happens to them. I'm like 18:49 wait wait wait the reason why we are one 18:50 is because we needed to work on 18:52 something. But number two, I think, you 18:54 know, and I I would say this is true of 18:56 all people, right? We all have whatever 19:00 level of education around health and 19:01 nutrition and other stuff. And when 19:03 everything's working, okay, we're like, 19:05 okay, my working knowledge of what I 19:08 know is working right. And then if you 19:10 add somebody like yourself or me, we've 19:12 got a ton more schooling, probably more 19:14 than we ever needed about what this 19:16 subject matter. And when the wheels go 19:18 off the bus, we are not immune to the 19:21 latest Tik Tok craze, the latest dietary 19:24 craze, the latest because it's always 19:26 based in a little bit of science. Yes, 19:28 there is even a diet that made it into a 19:31 publication about eating ice cream as a 19:33 dietary food, right? There is plenty of 19:36 subtifuge in in medical research. But 19:40 when you when you're in that state, and 19:42 I would say most women in pmenopause, a 19:44 lot of women, we get to this point, it's 19:46 like the wheels are off the bus. My my 19:48 body is gaining weight. Like I will do 19:50 anything at this point to feel like I 19:52 have some control because what I thought 19:54 was real is no longer real. And so you 19:57 and I are not immune to that. I did 19:58 keto. I was just like, well, let me see 20:01 what happens with hardcore keto, you 20:02 know? And I I gained probably 10 lbs and 20:05 my cholesterol went from like 205 to 20:08 320, 20:10 right? All the markers went nuts just in 20:12 a matter of like 2 months. And and it's 20:14 because of that APO A2 and and its 20:16 interplay with APOE. I have a 24 so I'm 20:19 2% of the population, you know, you know 20:22 what I mean? But there was all this, you 20:23 know, my inflammatory tone, all that 20:25 other stuff was triggered. And you know, 20:27 and I think, you know, too many of us 20:29 are sort of just grasping at straws 20:31 trying to figure out and so we're we're 20:34 easily subject to the latest ad on 20:37 social media in particular because 20:39 they're all designed to sort of pull at 20:40 those strings for everybody. So, I think 20:42 for any woman that might be listening 20:44 that's like, I just feel like I'm, you 20:47 know, playing whack-a-ole. Maybe part of 20:49 the big whack-a-mole is you don't know 20:51 how you were wired to begin with and 20:53 what was really protective to your 20:54 ancestors that isn't being triggered 20:56 properly now. 20:57 >> Yeah. And I think that one of the things 20:58 genetics does is to help us ask better 21:01 questions, right? How are hormones being 21:04 produced and activated? Can they 21:06 communicate with the cells? You know, 21:07 what what's the receptor like? Can they 21:09 be metabolized and and eliminated 21:11 efficiently? What are they binding to 21:13 and how strongly? And and then there's 21:15 the rest of the environment that this is 21:18 happening in. And I think that 21:20 pmenopause and menopause time of life is 21:22 when a lot of other things shift. 21:24 Thyroid can shift. Metabolism can shift 21:27 not only because of the hormones, but 21:28 just because sometimes that can happen 21:30 for people where they're they're aging a 21:33 little bit. Maybe their mitochondria has 21:35 gotten to a point where it's a little 21:36 tired and their the detoxing that 21:38 they've been doing up until this point 21:41 that may not be as strong as they'd like 21:43 it to be, it catches up with them, 21:45 right? And so it's sort of this this 21:48 sweet special spot that we can get 21:50 ourselves into where sorting all of that 21:53 out becomes a lot easier with more 21:56 information and different kinds of 21:58 questions. 22:00 >> Absolutely. You know, one of the things 22:01 that I wanted to dig in a little bit 22:03 was, you know, talking about polygenic 22:05 scoring. So for everybody listening, you 22:07 know, we have mutations that we can get 22:09 either your wild type, more common or 22:11 less, right? Which is the mutation. And 22:13 then the polygenic score is these these 22:15 combination of genes together and how 22:17 they influence kind of whether we're 22:19 going north, south, east or west, 22:21 whatever direction. But particularly I'm 22:23 interested in having a conversation 22:25 around kind of the polygenic activity 22:27 between our hormone metabolism and also 22:31 where it interplays with the things we 22:33 think about with brain chemistry, right? 22:35 Your neurotransmitters because there's 22:37 an incredible overlap both at receptor 22:41 sites but detoxification. The entire 22:43 pathways overlap. You know testosterone 22:46 and and dopamine go through similar
How genetics shapes cardiovascular and metabolic risk 22:48 pathways along with estrogen. And so, 22:51 you know, I because a lot of times women 22:53 will feel, especially in pmenopause and 22:55 menopause, I'm anxious, I'm irritable, 22:57 I'm depressed, and they kind of latch on 23:00 to it's, oh, it's the serotonin. And 23:03 it's the medical industry has done that. 23:05 You know, they're like, oh, well, you 23:06 just need an anti-depressant, then you 23:08 need a sleep medication, then you need 23:09 an anti-anxiety pill because you're 23:11 getting anxious. When it is this 23:13 incredible overlap. So what do you see 23:15 at the DNA company that is is some of 23:18 the kind of leading patterns that happen 23:20 here that may explain a lot of the mood 23:23 and neurological symptoms that are 23:25 usually the first harbingers of 23:26 pmenopause. So because of the pathway 23:29 overlap when something goes out of 23:31 balance it's going to affect everything 23:33 else. So for instance in pmenopause 23:36 a lot of times and there are always 23:38 exceptions to everything progesterone 23:40 goes down first and estrogen does this 23:44 fun little thing where it will spike and 23:47 trough in a different kind of rhythm 23:50 than it did when people were ovulating 23:52 regularly and having more rhythmic 23:55 cycles. So instead of it spiking just 23:58 before LH and FSH um and triggering 24:01 ovulation cuz it has to get to a certain 24:03 threshold before that happens and then 24:05 going down nicely like a well- behaved 24:07 estrogen and having progesterone rise 24:10 after ovulation. You can have estrogen 24:14 spikes at any point in the cycle. You 24:16 can have troughs at any point in the 24:17 cycle. So when you have those spikes, 24:19 some of the same detoxification needs to 24:22 happen to that estrogen that h that 24:24 happens with uh things like 24:25 norepinephrine 24:27 um and that happens with dopamine, 24:29 right? So the and especially if you have 24:32 slower comp, which is just just one 24:34 gene, but but it's sort of important for 24:37 for this particular thing because it's 24:39 important for all of those things. And 24:41 so the poor little comp can sometimes 24:44 get a little bogged down by estrogen and 24:47 then you could be stuck in fight or 24:48 flight for longer uh when when you're in 24:51 this norepinephrine situation or you 24:54 your maybe dopamine is is clearing 24:56 differently than it was in the past. So 24:58 there that's one of the places that I 25:00 see this and and the same is true for 25:02 testosterone which then also can stay 25:04 higher rel you know sometimes it's the 25:07 last soldier right and so uh so relative 25:10 to other things it can be higher and you 25:12 can run into the same sorts of things so 25:14 it that's why knowing the genetics you 25:17 you then don't want to be putting other 25:19 things that further slow down the the 25:22 metabolism of these substances into your 25:25 body at the same time. So, you know, 25:27 there are a lot of longevity supplements 25:29 that have a ton of queretin in them and 25:32 that also slow can slow down comp and 25:34 kind of bog it down. It gives it more to 25:36 to work on. So, someone is trying to do 25:38 this wonderful thing for themselves. 25:40 They're like, I'm going to do this 5 25:41 days out of the month. And I'm not 25:43 saying that that's going to necessarily 25:44 harm them, but they may notice that the 25:48 result of that is more of a mood issue 25:51 than would be expected if they weren't 25:54 doing that. So, it's it's all about 25:56 timing of of your interventions and 25:59 looking at who you are and where you are 26:01 in your life and what's happening. Okay. 26:03 So, I'm going to defend the slow comped 26:05 people. They call it the executive gene. 26:07 There's a lot of us, just so we're 26:09 clear. 26:10 >> Slow comped, 26:11 >> right? You're Yeah, you're like squirrel 26:13 and I have to do three things at once. 26:16 But but often those are the people that 26:18 are are playing roles in in executive 26:21 environments because they have to keep 26:23 multiple plates spinning. But you know, 26:25 here's something that I've found 26:26 anecdotally and I'd be interested to see 26:28 if you see the same thing that the slow 26:30 comped people get very used to their 26:32 chemistry, 26:34 right? Because it's kind of like getting 26:36 a little bit of crack all day long. And 26:37 when things are volatile behind that, 26:41 and most of this is going to be estr 26:42 estrogen's volatility behind that, what 26:45 they often feel despite the fact that 26:47 they're sort of in this, you know, kind 26:49 of exacerbated stress response, they 26:52 don't get the buzz off of it anymore. 26:55 And so then what do they reach for? 26:57 Stuff that makes it worse. They're like, 27:00 I need some tyrrosine. I need something 27:01 to help my dopamine. I'm not feeling. 27:03 And then Kathy, they they'll hit it from 27:06 all sides and they truly honestly make 27:08 it worse because they're looking for 27:10 that that balance that they felt, right? 27:14 Because some of the bigger movers are 27:16 probably fluctuating behind the scenes, 27:18 which is like testosterone and estrogen. 27:20 And I think it's interesting because 27:21 most people go, "Oh, no, no, no. They 27:23 feel they feel ramped up. They're going 27:25 to want something." I'm like, "No, no, 27:26 no, no, no. The ramped up people like 27:28 feeling that way. They're used to it. 27:30 And it's how they've gotten it's their 27:31 winning formula. It's how they got here, 27:33 right? That's how they got stuff done. 27:34 But when it starts getting wonky, if 27:36 you're one of those people and you're 27:37 like, "Somebody just unplugged my jets." 27:40 You are probably a slow comp and you you 27:42 need to hit it from multiple directions 27:44 so you don't feel like somebody bottomed 27:45 you out while you restore balance, you 27:49 know. Yeah, that's so interesting 27:51 because then sometimes the estrogen 27:53 result can make you feel really brain 27:55 foggy, right? And and kind of cranky and 27:58 stuff like that. And so there's this 27:59 edgginess. But I am also homozygous slow 28:02 comp. So I I did recognize a little bit 28:05 of myself in [laughter] what you were 28:06 saying. You you know 28:08 >> totally me. 28:09 >> If you use if you use your stress in a 28:11 proactive way and you can feel like 28:13 super human because of it, then when you 28:16 don't feel like that anymore, it can 28:18 feel like a loss. So So that's that's a 28:20 very interesting thing to uh to think 28:22 about. For sure. 28:23 >> Yeah. But I think I think for anybody 28:25 that's kind of in that zone because 28:27 somebody else that might be a fast comp, 28:29 they just often can get overwhelmed by 28:32 things because their their feel-good 28:34 stuff doesn't stick around very long and 28:36 you know and and so you know I think you
Hormone metabolism, detox pathways, and mood 28:38 know it goes both ways but that that 28:40 certain behavior type of that slow 28:42 comped person like I can pretty much put 28:45 money on it every time. I'm like, I got 28:46 a thousand bucks. [laughter] 28:48 I mean, I'm so pumped. I can feel it cuz 28:50 I'm that way. I am that person, you 28:52 know? I'm like, do not make me feel like 28:54 I'm unplugging my jets because that is a 28:56 really uncomfortable feeling. Now, I 28:58 work very hard on the other side to 28:59 balance that out with, you know, stuff 29:02 that drives kind of calming of the 29:03 parasympathetic drive. But I will not 29:06 allow for that to happen by choice 29:08 because it makes me feel just really 29:10 terrible. 29:13 Yeah. 29:15 Yeah. Yeah, that's so interesting. 29:16 >> You're not going to see me downing a 29:17 bunch of queretin, right? I'm not going 29:18 to do anything. I don't care if it helps 29:20 my longevity and and helps gets rid of 29:23 scinesscent cells. I'm not doing it, 29:27 >> right? 29:27 >> Unless I'm vacationing. And what a 29:30 vacation you'll have. 29:32 >> Exactly. [laughter] 29:33 I'll just be laying out somewhere on a 29:35 mattress like, "Oh my god, what am I 29:37 doing in a pool?" That's hilarious. 29:42 That's so true. But I but I you know I 29:44 think the take-home message for 29:46 everybody that's kind of listening to 29:47 us, it's 29:49 the way we feel, the way we go about our 29:52 lives, the way we even live within our 29:55 environment is very much a combination 29:58 of our genetics. And when you feel like 30:00 a canary, that's a sign that you have 30:03 some unique genetic pathways. They're 30:05 not in concert with how you're living. 30:09 Not necessarily. Sometimes it's things 30:11 you can fix. Sometimes it's things you 30:12 can't fix, you know. So, you know, 30:14 sometimes we can't change where we're 30:15 living and how we're living and things 30:16 like that, but it's it's something isn't 30:18 congruent with your environment or food 30:20 and other stuff that that your body is 30:22 not necessarily wired to be optimized 30:24 in. And I think that's the important 30:26 part. 30:27 >> Yeah. And some things really do point to 30:29 more testing. Dio2 makes you, you know, 30:32 if if you're sub-optimal there, maybe 30:34 getting a a test to see if you're 30:36 converting T4 to T3 quickly enough is a 30:39 really good idea. you know, there there 30:41 are very practical applications to a lot 30:43 of these things. And so when people 30:44 aren't feeling quite right, I mean, 30:47 personally, I think that everyone should 30:48 should get this test done when they're 30:50 infants so that their parents know how 30:52 to take care of them best. If my parents 30:54 had had been able to do that for me, I 30:56 would have not had as many ear 30:57 infections as a child because gluten and 31:00 dairy are not my friends and I was 31:02 eating a lot of that my entire childhood 31:04 and just having these very chronic 31:06 things happening. But it doesn't matter. 31:08 You can be 70 years old and it's still a 31:11 good time because then it gives 31:13 information about bone health and about 31:15 what kind of exercise your body likes in 31:18 what proportions and just a ton of 31:20 information that can really a I think 31:24 that when people feel seen when they 31:26 look at our reports 31:27 >> and they're like yeah that is me and and 31:31 then they're like they there's 31:32 self-acceptance there right and B if 31:36 you're given a blueprint of how to take 31:38 care of yourself. People are always 31:39 saying things like that. You know, I 31:40 wish that my kid came with an 31:41 instruction manual. This a little bit is 31:44 one, right? It's like, well, here here's 31:47 here's a starting place for that. And it 31:50 and no matter how old we are, having a 31:52 little bit more information, I was able 31:53 to change some things in my 40s. Now I'm 31:56 50 and I feel better than I did in my 31:58 early 40s and even probably in for a 32:01 significant portion of my 30s. And it's 32:03 because because I'm living more the way 32:05 that my body wants to. 32:07 Yeah. Could you imagine? Yeah. The all 32:09 the behavioral and mood things that are 32:11 that are that show up through your 32:13 polygenic score, like how much you would 32:15 change your parenting based on how your 32:18 child was going to react to your attempt 32:21 at control. Because let's face it, 32:22 that's what parents want is control. And 32:24 kids are going to act differently based 32:26 on their genetic pathways. 32:29 Well, and even in my relationship, 32:30 knowing that that the partner that I was 32:32 with when I had the testing done had a 32:35 completely different response to 32:37 cortisol and uh noradrenaline 32:40 norepinephrine than I did. So, because 32:42 it took me longer to clear and because I 32:44 was a little bit more reactive on my HPA 32:46 access to cortisol and a little bit 32:48 slower to put on the brake, he cleared 32:51 really fast everything. So, you know, if 32:53 if something happened, he'd be like, 32:55 "Well, why are you still upset that that 32:56 person almost, you know, drove us off 32:58 the road or something like that?" And 33:00 I'd be like, "Well," and then once I got 33:01 my genetics done, I was like, "That's 33:03 because it takes me longer to to clear 33:05 to calm these chemicals down and to 33:07 clear them out of my system." And for 33:08 him, it was like that, right? And so, 33:10 just knowing, 33:12 >> right? So, 33:13 >> I'm married to somebody who is not 33:15 right, it's gonna stick for a long, long 33:17 time. And he's always like, "How do how 33:19 do you just get over that?" I don't 33:20 know. I'm just done, you know. I was 33:22 like, okay. I was like, I don't know, 33:25 you know. But knowing that then then it 33:27 helps it helps you have empathy and 33:29 understanding for how somebody might act 33:31 in a particular way or show up in the 33:34 world. 33:35 >> Yeah. In either direction, right? It's 33:37 like, how can that not still be 33:38 bothering you, right? I didn't say that 33:40 anymore. I was, you know, I didn't I no 33:43 longer wondered. It was like, oh, okay. 33:45 It's just biology, right? this that's 33:47 just how you were designed versus how I 33:49 was designed. 33:51 >> Exactly. Exactly. Now, let's dig in 33:53 because I I we I talk about it quite a 33:55 bit, but but we've kind of danced around 33:56 it. Let's talk a little bit specifically 33:58 about hormone metabolism and how you 34:02 really look at it at the DNA co and how 34:04 you sort of put those pieces together to 34:05 help people understand how they're wired 34:08 around their hormones. 34:11 >> Absolutely. So the first thing that we 34:13 look at is hormone production and 34:15 activation. So you know there are some 34:18 genes that are around steroid hormone 34:21 synthesis and then you know there's one 34:23 SIP 19A1 which is around aromatase 34:26 activity. So that's going to convert 34:28 testosterone into estrogen. Some people 34:30 do that much more quickly than other 34:32 people. And so this is one of the 34:34 reasons why people's responses to things 34:38 can be really different. So someone who 34:40 for instance is taking HRT and they 34:43 decide to incorporate some testosterone, 34:46 if they're a more of a fast converter of 34:48 that testosterone, it can have a 34:50 different effect from someone who is 34:52 more of a slow converter. And and that's 34:54 something that I think is really 34:56 important when people are speaking to 34:57 their doctors about dosage and things 35:00 like that is that there's this there is 35:02 a difference in how these things are 35:04 produced and then then how they're 35:06 bound. you know, we look at which is 35:10 about androgen receptors and if the 35:12 androgens are floating around but 35:14 they're not really binding well, if that 35:16 that sensitivity isn't there, people may 35:18 have a harder time putting on muscle. 35:20 Um, and and then you have to also look 35:22 at SHBG, you know, and then how tightly 35:25 are these things bound? how much is 35:27 actually available for tissue use versus 35:30 being trapped by this this binding 35:33 globbulin and just hanging out like a 35:36 little bit like they're on a roller 35:37 coaster that they can't get off of and 35:39 they're not it's it's not making it to 35:41 where where it's going to be as useful 35:43 as you might want it to be. So, so 35:45 knowing that hormones don't just need to 35:47 be present, they have to be able to 35:49 communicate and almost like be heard by 35:51 the body in order to do what they're 35:53 supposed to do. And then there's 35:55 metabolism and elimination. 35:58 And so, you know, we have 36:00 we we talk about estrogen toxicity. And 36:03 people get a little freaked out by that 36:05 term. And so, I just want to explain 36:07 that that doesn't mean you're going to 36:09 be toxic. It doesn't mean you shouldn't 36:10 take HRT. It doesn't mean any of those 36:13 things. It means that you you 36:14 genetically have a tendency to instead 36:17 of metabolizing down one pathway, 36:19 metabolize down one or more of these 36:22 other pathways where then it's a little 36:25 bit harder for it to become water 36:27 soluble and and leave the body. It 36:30 doesn't mean it's impossible. It doesn't 36:32 mean you're you're not doing it through 36:33 the through the pathway that's easiest 36:35 or anything like that. It just means 36:37 watch out for these symptoms uh because 36:39 you might need to do lifestyle things in 36:43 order to mitigate this, right? And then 36:45 there's the the rest of the metabolism 36:49 and elimination through sulfation, 36:51 glucaronidation, glutathione, and 36:54 methylation. And fortunately, we have 36:56 multiple ways that we can finish uh that 36:59 we can do the phase 2 detoxification. 37:01 So, even if someone shows up on their 37:03 report that they're not great at one of 37:05 them, it doesn't mean that you're out of 37:07 luck. And this is one of the I love the 37:09 Dutch test, but one of the limitations 37:11 of it is that it's only showing it's 37:13 only showing this one way. And so, if 37:16 someone gets a not great score there, 37:19 they're thinking, "Oh, no. I'm building 37:21 up all of these things." Right? And 37:23 there are these other pathways that they 37:25 can leave. And and it also doesn't take 37:28 into consideration the gut, you know, 37:30 and I know that you and I talk about 37:31 this and about, you know, betagluconase 37:34 and things like that and and about 37:35 elimination, which is phase 3 37:37 detoxification. So knowing your 37:39 microbiome tendencies is helpful there, 37:41 but also getting testing done. So how I 37:44 think about it is if we know that we 37:46 have a genetic tendency, 37:49 we can then do other testing to see 37:51 what's actually happening. It's not a 37:53 it's not a life sentence, but it's a 37:55 tendency. It's okay. We need to pay 37:56 attention to this, right? It's like a a 37:59 signpost. It doesn't mean that that's 38:01 your destination. It means you could go 38:04 that way. If if you head down this 38:05 highway long enough, eventually you're 38:07 going to reach Arkansas. I don't know
Exercise, recovery, and stress response differences 38:08 why I picked Arkansas, but if you make 38:10 another turn, you're not going to get 38:13 there. You're going to end up in 38:15 Saskatchewan. I don't know what kind of 38:17 a turn you would have to make in order 38:18 for that to happen, but but that's how 38:21 drastic it is, right? that that you have 38:23 you have options in terms of how things 38:26 turn out and and it doesn't need to be 38:28 something that's really concerning. But 38:29 we do we look at all of those things and 38:32 then we look at how inflammation is 38:34 playing into this and you know 38:36 glutathione creation versus utilization 38:40 and how the mitochondria are functioning 38:42 and all of these things are really 38:45 important for pmenopause and menopause 38:47 and hormonal health in general as well 38:50 as sleep. I mean, sleep can be affected 38:52 by hormones, but it also affects 38:54 hormones and stress and hormone health 38:57 isn't about avoiding stress certainly, 38:59 but knowing how you recover or don't 39:01 from stress as easily. I mean, all of us 39:04 recover from it eventually, but if it's 39:06 taking you a little longer than knowing 39:08 how to how to manage that and how to 39:10 prioritize it as something to look at 39:12 because in during times of hormonal 39:15 fluctuation, those types of things can 39:18 seem really big. It can seem like 39:20 there's a magnifying glass being shown 39:23 on how people process their cortisol. It 39:26 likewise with thyroid. You know, these 39:28 are it's like a spotlight being shown 39:30 there. And so, if you know these things 39:32 ahead of time, you can you can tell what 39:34 to focus on. Same thing with blood sugar 39:36 and and some of the cardiovascular 39:38 things. And all of these are connected. 39:40 It's almost like it's all part of one 39:43 body. 39:44 >> Yeah. Imagine that. No, I think that's 39:46 really important because you know 39:47 because again medicine has been siloed. 39:49 You know you have a gastronurologist, 39:51 you have a cardiologist, gynecologist. 39:53 Nar do they meet and never will they 39:55 ever talk about the same thing. But I'm 39:57 like okay a woman has hormones so 39:59 therefore that means that their hormones 40:01 affect every body system including 40:03 cardiovascular all these other things 40:05 and you can't separate them. You know, I 40:08 I mean, I can tell you betaglucaronidase 40:11 research and the ability to excrete 40:13 estrogen through glucaronidation and 40:15 sulfation, especially sulfation, has 40:18 associations with inflammatory pathways 40:20 and backwards all the way back to like 40:22 Alzheimer's risk. It's loose, it's 40:25 loose, there's like signals there, 40:27 right? and it's because we don't have 40:28 enough research. But like there's 40:30 combinations there that are that are big 40:32 that cross all these other barriers, but 40:35 we just don't have the data particularly 40:37 in women's health yet because we just 40:38 haven't funded it. But you know, like I 40:41 look at it and I go, okay, I have I just 40:43 did not win the genetic lot. I do not 40:45 have Keith Richards. You know, I have 40:47 pretty rough kind of, you know, 40:49 cardiovascular genetics. I have six 40:51 copies of 9P21. It's like, oh, okay. 40:53 Like I never knew that. I did triathlons 40:56 and I wondered why I felt terrible doing 40:57 them. I'm like, "No wonder." I still 41:00 cycle, but I don't do it very often. You 41:02 know what I mean? Like there, but you 41:04 know, but now, you know, and it's and 41:06 it's made worse when you're inflammatory 41:08 and you've got all these other cascades 41:09 going on in pmenopause and menopause. 41:13 >> Absolutely. Yeah. I couldn't do really 41:15 big exercise things suddenly. And that's 41:18 my my for me it's it's 9P21 and my 41:20 mitochondrial report, you know, is is 41:22 not ideal. So, I can build up to things, 41:26 but I can't just bike straight up a hill 41:28 or I'm going to get a migraine and have 41:30 to, you know, go to bed and feel really 41:32 sick and awful. And I think it's it's 41:35 because of of some of my detox and 41:37 inflammation and mitochondrial things 41:39 and but it's okay. I still consider 41:41 myself athletic, right? I just have to 41:44 do things my way. 41:47 >> Yeah. Like I'm an explosive like I'm an 41:49 explosive athlete, right? So, I can I 41:52 can attack on a bike pretty much any 41:54 given time. Just don't ask me to go all 41:56 out for a really long period of time, 41:58 you know, because I don't have I don't 41:59 have any endurance genes whatsoever, 42:01 right? And so, you know, but again, I 42:05 would have liked to have known that. I 42:06 would not have put myself through a year 42:08 and a half of Olympic distance triathlon 42:11 training. Like, got that t-shirt done. 42:14 Don't need to do that again. I should 42:15 have not done it in the first place. 42:18 >> Right. Well, and some of the social 42:20 bonding stuff too, like some of the 42:22 genes that are in some of the reports 42:24 are about does socialization help you to 42:28 alleviate stress or maybe it's going to 42:30 end up causing a little it's maybe it's 42:33 not that beneficial to you, right? So, 42:35 and sometimes people then overuse that 42:38 where 42:39 >> the bonding feels so good that then they 42:41 want to kind of solve other people's 42:43 problems rather than all day long rather 42:46 than trying, you know, kind of managing 42:48 their feelings, right? That becomes 42:50 their stress relief. Um, and they can we 42:52 can overuse a good thing at 42:55 [clears throat] any point. All of us 42:56 have these really strong parts of our 42:59 ourselves, but sometimes there's a 43:01 little bit of balance that's needed. And 43:03 if we can see that uh then we can we can 43:06 better we can better do the balancing 43:08 act. Right. 43:09 >> Right. Right. Well, and chances are 43:11 you're probably in a partnership with 43:12 somebody that has a different social 43:14 bonding tendency. I don't know why that 43:17 is, but that's how we end up connecting. 43:18 Probably because we'd kill each other 43:20 for exactly the same, you know, right? I 43:23 know if I was around somebody who's just 43:24 like me, we'd probably wear each other 43:26 out for sure [laughter] 43:29 because my like from a socialization 43:31 standpoint, I I need people. I don't 43:34 have to be interacting directly, but I 43:36 need to be in the vicinity of people on 43:37 a regular basis. I can definitely do 43:39 isolation and time alone, but my 43:41 husband's like pretty much a nine on the 43:43 introvert, and you know, one is good. 43:46 That's all I really need, you know, and 43:48 so we have we have at this point in our 43:50 life a lot of separate social things. I 43:52 go do stuff and leave him at home, you 43:54 know, because it's better for both of 43:55 us. 43:56 >> Absolutely. Absolutely. And I think that 43:59 that one of the other benefits in terms 44:01 of hormone stuff is that certain people 44:04 are going to be more 44:06 responsive andor sensitive to certain 44:09 ways that things are administered 44:11 because of liver stuff or skin stuff or 44:15 gut stuff or whatever the thing is. how 44:18 they receive their hormones is can also 44:20 be impacted by genetics. And so for 44:22 practitioners to be able to understand 44:24 some of those things is really helpful 44:26 in terms of the individuality. 44:29 >> You know, I know that you guys really 44:30 look at people as individuals when 44:32 you're you're doing hormones and and so 44:35 do we at the DNA company because 44:36 otherwise like the the rule of this well 44:39 it works for 80% of my patients like 44:41 what about that 20%. I swear they're all 44:43 coming to us. 44:44 >> I know. I'm like no no no we have the 44:45 outliers. We are the we take care of the 44:47 outliers because yeah, you know, well, 44:50 you know, well, because the people that 44:53 don't seem to have symptoms don't know 44:55 to look for individualization
How the DNA company test works and where to get it 44:58 because they're not necessarily 44:59 triggered by something, you know, and 45:01 it's the unfortunate truth because if 45:02 they feel well, they might be able to 45:04 feel even better. Or maybe not. We don't 45:06 really know. But we know the people that 45:08 are like, I tried that and that doesn't 45:09 work come seeking, right? So they come 45:11 to DNA company, they come to Manurva, 45:13 they come to Living Well Dallas, you 45:15 know, because they're like, "What I've 45:16 been told to do is not working for me, 45:19 you know." Absolutely. It would be sort 45:21 of like, you know, two people working at 45:22 a perfume counter and one of them comes 45:24 in and they're just like crying and 45:26 their nose is congested and they're they 45:28 can't breathe because of of all of the 45:30 smell of perfume and another person is 45:32 totally fine, right? And that right 45:34 there is that that's real. that happens 45:37 to people and it's not that one person 45:39 is pretending to be sensitive to like 45:43 get more breaks or something. It's it's 45:45 that that's how their body is responding 45:47 and it's it's genetic and it's not their 45:49 fault. 45:50 >> Absolutely. Absolutely. So, if somebody 45:53 was listening and they're like, "Oh my 45:54 gosh, you know, I think I need this." 45:56 Let's talk a little bit about how the 45:58 test is ordered. What do they have to 45:59 do? So, so tell us a little bit about 46:01 that because you have the new new 46:02 version which has more genes, more 46:04 polygenic scores. So, so if somebody had 46:07 their test done three years ago, they 46:08 need to do the new one, you know, I 46:11 mean, if they want more information, 46:13 yes. You know, so we still sell, we call 46:15 it the DNA 180, um, because it has about 46:17 half as many genes that are looked at as 46:19 as the new test, and it still is a 46:22 really good entry point for someone who, 46:24 you know, doesn't want to feel 46:26 overwhelmed by the number of genes, but 46:27 it's not as complete. It's it's a more 46:29 clearer picture with more connections 46:31 made. So it's more specific to the 46:33 person the more genes are looked at, 46:35 right? It's just a the analogy we give 46:38 is that it's like rabbit ears on a TV as 46:41 I date myself. Uh versus a satellite 46:44 versus cable, you know, it it things get 46:47 more and more clear as as things go on. 46:50 And so both tests are saliva based and 46:53 you it's just a cheek swab. It gets 46:55 ordered either through the company 46:57 website, the DNA company.com, or from 47:00 any of our many participating providers, 47:03 one of which, you know, Dr. Dr. Murray 47:05 is one of our very preferred providers. 47:08 You do the cheek swab, you mail it back 47:10 in, and then in 7 to 10 days, lab days, 47:14 which you know, it's 6 days a week that 47:16 the lab runs, you you have these 47:18 answers, and that comes up in our 47:20 portal, and then all of the reports are 47:22 there. So, you don't need to be a 47:24 medical professional in order to get 47:26 something out of being tested, right? 47:29 It's not like you're just given this raw 47:32 piece of, you know, just letters and 47:34 that don't mean anything to you. The 47:36 interpretation is done for you of the of 47:39 the report and the assessments. You 47:41 know, this is you have a a higher risk 47:43 of, you know, 47:46 cardiac risk or you have a a lower risk 47:49 of being celiac. you know, we we have 47:51 all of these different assessments that 47:53 are done and you don't need to worry 47:55 about which genes are involved in it, 47:57 although we do tell you, but you you 47:59 don't need to be able to to know 48:00 anything about them in order to benefit 48:02 from the testing. And I do encourage 48:05 people to to get it done for their kids 48:07 and grandkids and siblings, and you can 48:10 compare notes and say, "It's no fair. 48:13 You can digest gluten better than I 48:15 can." You know, fun conversations like 48:17 that. 48:18 >> Absolutely. Yeah. And and like we've 48:21 been saying, you know, it's just another 48:22 way to understand kind of how you're 48:24 wired so you can make better choices 48:26 because we're all trying to live a 48:28 longer health span. And this is a good 48:30 way to sort of narrow that down so you 48:32 also know your big ticket items that you 48:34 want to go look at. You can go run tests 48:36 on everything, but let's figure out the 48:37 big things, the big ones that we 48:39 probably need to watch first. 48:41 >> Absolutely. Prioritizing uh prioritizing 48:44 what to do and when. And we also do a 48:46 lot of education. You know, we have we 48:48 have Dr. Murray on all the time. We have 48:50 a a master class with Dr. Murray and Dr. 48:52 Hornman coming up in in May. Dr. Murray 48:55 was just on our she summit which was an 48:57 all day Saturday event. Um and we have 48:59 three free webinars every week um where 49:02 all we're talking about is different 49:04 things about genes, how it interacts 49:06 with this, what it has to do with 49:07 inflammation and autoimmune disease and 49:09 menopause and all of the things. So, you 49:11 know, if you want to know more, that's a 49:14 really great way to to see what we're up 49:16 to and what we're doing. Absolutely. 49:18 Well, Dr. Steady, this has been 49:20 fantastic. You and I, God knows we've 49:22 spent so many hours on [laughter] live 49:24 webinars. 49:26 Yes, we have. We've spent a lot of time 49:29 together. It's been great. And I'm I'm 49:31 so happy that we got a chance to talk 49:32 about this and and so we will make sure 49:35 to put information in the show notes and 49:38 say the website so everybody knows 49:40 exactly where to go in case they can't 49:42 get the show notes. 49:44 www.thednaccomp.com. the DNA company.com 49:47 spelled out th hhe dna and then 49:50 alloftheword company.com. 49:53 >> Perfect. Perfect. And then we will have 49:55 that in the show notes and that's where 49:56 you can go and get your lab test and get 49:59 started and and get some answers if you 50:02 haven't had them before. And if you have 50:04 done a DNA test, I can pretty much 50:06 guarantee because for a while there we I 50:08 would do a lot of people's just to kind 50:10 of compare and see even where they made 50:12 like I was like that's actually not the 50:14 way the genetics work in that pathway 50:15 because they can make mistakes on 50:17 interpretation. But even if you had one 50:20 you're like it doesn't seem complete or 50:21 it doesn't seem leg you know to kind of 50:24 answer all the questions you want. It 50:26 may be because they're looking at genes 50:28 individually and that has always 50:29 frustrated me. You know, I' say take 50:31 B12, don't take B12, take methylated 50:33 B12, take hydroxy B12, take Cabalamin, 50:36 like all of these like, okay, which one 50:38 am I supposed to like judge, 50:40 >> right? Yes. Yeah. you then have to do 50:43 the interpretation yourself, which is 50:45 why having us do the interpretation for 50:47 you, we can look at the entire 50:48 methylation pathway and make a 50:50 recommendation about that based on 50:52 everything, not just one gene that then 50:55 is contradicted by the next gene. So, 50:57 >> yes, absolutely. Well, Dr. Steady, thank 51:00 you so much. 51:02 >> Thank you for having me. You're welcome. 51:04 You're welcome. Okay, everybody. If you 51:06 are listening online on your favorite 51:09 podcast platform, don't forget to leave 51:11 some five-star reviews. And if you 51:13 happen to be watching us on YouTube, 51:15 please subscribe so you don't miss the 51:17 next episode. And leave us a comment. 51:19 And if you'd like to see certain 51:21 information being covered on Menopause 51:23 Mastery, leave it in the comments there 51:25 and I will add it to recording schedule. 51:27 And we'll see you next week.
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