Full Transcript Introduction to Dr. Russell Jaffe 0:00 the cause of atherosclerosis, coronary artery disease, all cardiovascular diseases. 0:08 stem from sugar imbalance, you probably know about that from hemoglobin A1C, but then inflammation, which is really repair deficit. 0:16 If you look at inflammation from the lens of the pathologist, You see five different harms. 0:21 When you see the opportunity to repair deficits, the symptoms go away when the connective tissue, Which means collagen and elastin, 0:31 are repaired. 0:32 This is Dr. 0:33 Talks. 0:40 Hey, everybody. 0:41 Good day to you. 0:42 Please stand, sit, move, but do not leave your screen whenever you're watching. 0:47 You're going to have one of the most fascinating and provocative topics and interviews we've done. 0:52 And if you don't know Dr. 0:53 Russell Jaffe, you are going love him at the end of this segment, and you going want to follow him. 0:57 Going to want read his books and maybe explore his vitamin company. 1:00 I say that unabashedly because I'm one the biggest fans. 1:04 Bachelor's, MD, PhD, Boston University, advanced training at National Institutes of Health, Advanced Training in Anatomic Pathology, 1:12 plus An enormous amount of Eastern medicine, formal training, acupuncture, mind, body, a very unusual combination of solid academic Western medicine and 1:25 very ancient and healing Eastern Medicine that culminated in him writing many papers, many books, at Think Tank, the Health Collegium, 1:33 and a wonderful integrative vitamin company called PERC, B-E-R-Q-U- E. 1:38 Which I'm a big fan of and have been through the certification process, which I'd encourage anybody in the health field to explore. 1:45 It was just fascinating. 1:46 If you want to know about acid base load and many other topics, Dr. 1:50 Jaffe may be the world expert on. 1:51 So welcome, welcome. 1:52 We're going to blow apart everybody's thinking on heart disease today, right? 1:57 I'm going to try. 1:58 Yeah, but in a thoughtful and academic way. 2:01 I mean, I said to somebody I interviewed, you can't talk about reversing heart disease unless number one, You can measure it. 2:09 And number two, understand why it develops. 2:12 Then you apply strategies to halt or reverse. 2:15 What's driving it? 2:16 And you're going to, we had some great imaging talks because that's how we can actually measure and now actually document reversal in this current decade 2:25 more accurately than ever. 2:26 But you are going tell us to rethink the very origin of cardiovascular disease, predominantly atherosclerosis. 2:33 So take it away. 2:34 Talk about repair deficits, oxidative damage, metabolic acidosis to a general public audience. 2:42 Well, thanks for the opportunity. 2:45 Yes, I am cross-trained. 2:46 I was curious and skeptical, but to feel, to find, explore, research, and document that we are looking far downstream.
Rethinking the Causes of Heart Disease 3:01 We look through the lens of the pathologist. 3:03 Now, i'm a clinical pathologists, not an anatomic pathologyist, But i am a Clinical Chemist Pathologist, doubly board certified. 3:13 But what I discovered along with the cross training was that causes are very different than symptomatic consequences. 3:22 And if you treat the symptoms, you will never ever get to the cause. 3:26 Now, what's the cost? 3:28 The cause is too much bad and not enough good. 3:33 What does that mean? 3:34 Because of atherosclerosis, coronary artery disease, all cardiovascular diseases, stem from sugar imbalance, you probably know about that from hemoglobin A1C, 3:47 but then inflammation, which is really repair deficit. 3:53 If you look at inflammation from the lens of the pathologist, You see five different harms and hopelessness. 4:01 When you see the opportunity to repair deficits and remove the consequences, the symptoms go away. 4:10 when the connective tissue, which means collagen and elastin, are repaired. 4:16 And the rest of you is repaired in that process, because it's all of us. 4:22 Mind and body, yes, for full disclosure, I'm a man of science and a men of spirit, and I find them complementary, not competitive. 4:33 So I think everybody listening, you know, was just fascinated by what you just said and is also probably familiar at least broadly with the term inflammation. 4:43 The middle word is flame, the immunologic system, maybe specifically that which is geared to react to cardiovascular pathology is overactive, 4:52 but because there is pathological going on. 4:55 But when you talk about repair deficit, are you talking about Trace mineral deficiencies, nutritional deficiences, genetic physician have weak collagen, 5:05 which is the structure of arteries. 5:07 92% of lifetime health is epigenetic lifestyle. 5:12 8% is transgenerational influences and genetics. 5:16 So I'm going to talk mostly about epi genetic lifestyle, Because if you get that right, it corrects most of the genetic problems as well. 5:25 So to be specific, we start with four self-assessments, which define whether you are in balance or out of balance. 5:33 And then we move on to eight, just eight tests, cover all of lifestyle epigenetics, all the 92% you can do something about. 5:44 And we use those eight tests to either, we interpret those tests based on the best outcome goal value. 5:51 I don't even look at the statistical range from the lab because it confuses me, but I want to know whether your hemoglobin A1C is less than 5%, whether 6:01 you're HSCRP is 0.5, whether homocysteine is 6, your lymphocyte response assay, which my lab does specialize it in, whether you're tolerant or intolerant 6:13 to what you are eating, because what your eating might be eating you. 6:17 Then you need to know your vitamin D, you to need know how much acid is coming out in the urine first in morning after rest. 6:26 You need you know what omega 3 index is and then there's an odd test, a urine test an easy to do test called 8-oxoguanine which measures damage in your DNA. 6:37 And in answer to your question, it depends on how much antioxidant you need, how many minerals you'll need. 6:44 How much anti-nutrients you're taking in. 6:48 You want to reduce the anti nutrients, you want it increase the good protective nutrients. 6:53 Ascorbate is the maternal antioxident that chaperones and restores all other antioxidants.
Four Self-Assessments for Health Balance 7:02 So we developed something. 7:04 Vitamin C. 7:05 comes in different versions and you... 7:07 Well, oh no, I'm only talking about Nature's ascorbate. 7:10 I am only taking about nature's vitamin C. 7:13 i'm talking only about fully buffered, fully reduced L-ascorbates. 7:17 Most of what you get on the shelf, even in the health food store, is vitamin c. 7:22 It is Vitamin C, but it's damaged. 7:24 Its damaged because it is made in air, not under a nitrogen blanket. 7:28 its damaged, because ascorbate requires a healthy low oxidation state. 7:43 You can make tons of vitamin C that is damaged and I don't recommend. 7:49 I'm only talking about nature's ascorbate, which means fully buffered, fully reduced L-ascorbates, as in not D-ascorbate not 50% D which is the synthetic 8:01 version of vitamin C, very cheap, but half of it doesn't get into your body and it's irritating to the digestive tract. 8:08 So you must have nature's ascorbate. 8:11 And I will talk extensively, if you want, about nature version of antioxidants and what does that mean, and minerals and cofactors, 8:23 what are the essential co-factories, because this can be explained in simple language. 8:31 The chemistry, that's a bit complex. 8:33 I'm not gonna get into electron donors and electron recipients. 8:37 If you wanna talk to me about that, I am happy to talk about it on another occasion. 8:42 Well, you know, again, we've already had a university hour of information in our first 10, 12 minutes. 8:48 I want to go a little deeper with you in your very well thought out eight predicted biomarkers of health and longevity. 9:01 handout on those eight and I review them with almost every patient. 9:05 And I tell them why we're getting advanced labs because these are predictive science-based measures. 9:11 But you said something about five minutes ago, first about, I think you called it four pillars of pathophysiology of maybe all diseases or heart disease. 9:19 Can you just flesh out what that comment was? 9:22 Cause I don't think we heard it. 9:24 Yeah, the headline is physiology before pharmacology. 9:29 I'm not opposed to good medicine, I am not to prescription medicines when they're helpful and needed. 9:36 But most of the time what we need is to induce repair, which means more antioxidants, more buffering minerals, and more cofactors, 9:45 reducing the harmful bad anti-nutrients that we're bathed in in the 21st century. 9:52 And that's why we wrote the book called How to Thrive, as opposed to Just Survive. 9:57 Eighty plus percent of people are surviving today. 10:00 They're just getting by. 10:02 they don't really feel well.They don t get restorative sleep. 10:05 T hey're not really very pleasant to be around because they d n't feel them. 10:11 The get by, day by day. 10:14 they're in survival mode. 10:16 So when we want to get people out of survival and into thriving, We start with four self-assessments, just four. 10:24 Very simple, very inexpensive. 10:27 What is your digestive transit? 10:29 How long does it take from the time you eat until you poop? 10:32 how much ascorbate does a take to do a cleanse? 10:35 What we call the C cleanse. 10:37 This is a global measurement of how anti-oxidant you need to deal with the oxidative stress that you're under that, you may not be aware of. 10:47 Then there are two more. 10:51 We wanna know if you're well hydrated. 10:54 You can decide whether you are well-hydrated in two seconds if know what you doing. 11:02 So these four self-assessments are very inexpensive, they're very easy to do. 11:06 They confirm for most people that they are out of equilibrium, that are of balance.
Key Biomarkers: A1C, Vitamin D, CRP, and Homocysteine 11:14 And what I want is to get them back into balance using physiology before pharmacology. 11:20 I'm already, people are saying, where can I get that information? 11:23 I know you don't have five hours with- No, no, No. 11:26 No no no. 11:28 I want to tell people, I am looking, i'm cheating. 11:31 iI'm looking at your website, PERQUE.com and there's a heading called the alkaline way, which is a wonderful ebook you wrote. 11:42 And then there is this section there called self tests. 11:44 and what you just said, People can take the time and go through and actually do those four tests of their physiology before pharmacology and find out their 11:55 transit time, their hydration. 11:57 So I just want people to know there's a lot to think about and it's all nicely laid out on your website. 12:03 Of course, you've got it there to make it easy for people. 12:06 We're trying to Make it Easy for People to Making the Transition from Sick Care to Healthful Caring. 12:15 Let's go a little slower for people listening. 12:18 I want everybody to take out a piece of paper, but I assure you, if you go to PerkPERQE.com, these eight biomarkers are going to be there for you to learn 12:29 about and study a bit more. 12:30 But let's through those. 12:31 They're urine and blood tests. 12:34 that predict longevity and overall health. 12:37 So I'm looking to my right and I see hemoglobin A, average three month blood sugar, glycation, easily available blood tests. 12:46 What's the optimal level and how predictive is that for health and longevity? 12:51 Hemoglobin A1c should be less than 5%. If you keep it less then 5%, you will live 20 to 30 years longer at low cost because you'll avoid diabetes. 13:03 It turns out that blood sugar and insulin are less reliable than hemoglobulin A 1c. 13:10 There are rare cases where hemoglobin A1C is not reliable because red cells are being destroyed too quickly and then you do fructosamine, 13:18 but please go to PERC or go DrRussellJaffe.com. 13:23 to learn more. 13:24 Right. 13:25 And I will say, anybody listening can ask their nurse practitioner, physician assistant, gynecologist, family doc, internist, 13:33 or endocrinologist or, God forbid, their cardiologist and say can you please check my hemoglobin A1c. 13:39 I would say ... Cardiologists today know about hemaglobin, A 1c, but they're trying to get it to lesson seven and I want it be lesson five. 13:47 Yeah. 13:48 And interestingly, we now have a number of drugs developed for diabetes, the lower the hemoglobin A1C that are being repurposed to congestive heart failure 13:59 and other syndromes. 14:00 So we actually are accidentally lowering hemaglobin. 14:03 That is helpful. 14:07 And that is helpful, but it is not as helpful as the physiologic restoration of sugar balance, which is what I recommend, 14:14 and which does even better. 14:16 So yes, we have a number of drugs that lower hemoglobin A1c, But then they interfere with your digestion or B12 uptake or magnesium up take. 14:26 They are two-edged. 14:28 they help and they harm. 14:30 And I want to help without harm, And I would say in my practice, where for at least a decade, every patient has gotten a hemoglobin A1c, 14:39 well under 10% have a haemoglobulin A11c under five. 14:43 So we got a lot of work to do to optimize them. 14:45 A lot a work do, and that's about right. 14:48 80 plus percent of people are out of balance. 14:51 Occasionally you meet someone who is pretty healthy and they're in balance and want to stay in-balance and should. 14:58 Probably the two most familiar of the eight predictive biomarkers, let's say vitamin D, everybody's heard. 15:04 I hope most people have had that checked. 15:07 What's your optimal level of vitamin B for health, longevity, functional age? 15:13 We absolutely know the question and we know, the answer, although it's controversial 50 to 80. This is 90 grams per deciliter. 15:21 50, 80 is the healthy range. 15:24 The average American is low. 15:26 There was an article in the New York Times that said recently, you shouldn't even test because everyone is low, therefore it's normal. 15:34 That means statistically average normal to be low. 15:38 So don't measure, don' know, Don't care. 15:41 I was very disappointed in that article. 15:44 And that was written by a very fine science writer. 15:53 Yeah, absolutely. 15:55 One is statistically true. 15:57 I used to teach statistics. 15:59 You know, you can make it interesting if you make relevant, but the word normal has a meaning in math that is different than in common parlance. 16:07 And I'll bet the readers of the New York Times took it to mean normal as in healthy. 16:12 and I'm saying the healthy vitamin D range is 50 to 80. We absolutely know that. 16:17 you don't want too much. 16:19 It's almost always the Goldilocks scenario. 16:22 Just right is just right. 16:24 And I will again offer from a whole lot of vitamin D blood levels in patients. 16:28 Unless patients are supplementing, even those that are in sunshine states, and even some that have outside jobs, it's very rare to see 50 to 80 without supplementation. 16:39 Even if you're a lifeguard on Tel Aviv beach, you probably need supplements because many people, Michael Halleck, Dr. 16:46 Sunshine says that over 40 or 50 million Americans don't absorb vitamin D from their gut. 16:52 So they must take drops under the tongue to get it to the brain first and then the body. 16:57 And then you can correct into the 50 to 80 range. 17:00 How many drops do you need? 17:01 Well, as much as you to need to you get you into 50-80 range and you measure vitamin as soon as a month. 17:08 It shifts very quickly. 17:09 It's actually a neuroendocrine hormone. 17:13 We call it a vitamin, but it's really a neural endocrin hormone, right? 17:17 Let's move on to another one. 17:18 I think most people will have familiarity with and hopefully know their blood level. 17:22 The high sensitivity CRP, C-reactive protein, optimal level for longevity. 17:27 Everybody should strive for. 17:31 Five, this is the work of Mater and Rafi, two guys from Harvard. 17:39 They showed that the average CRP is not sensitive enough at the low range to be meaningful to guide care, but the high sensitivity CRPs is, 17:49 and it should be less than 0.5. Okay. 17:51 Easy test to ask your medical team to get for you. 17:55 Then we maybe get one more that I would say would be maybe two more easy to your homocysteine blood levels. 18:01 Simple blood test. 18:03 Every lab does it. 18:04 What are we shooting for in that situation? 18:08 Well, Kilmer McCulley showed in the 1960s that if your homocysteine is low, your methionine will be high, you're methylation will adequate and good. 18:19 And so we want a homocistine of less than six so that methylation and cardiovascular repair can take place. 18:26 We may have to alter diet, we may to use supplements to reach that optimal level, correct? 18:35 And nature supplements, always nature's form of the supplement.
Omega-3 Index, Urine pH, and Oxidative DNA Damage 18:39 They are essential. 18:41 they are called essential because we can't make them. 18:44 We have to take them in. 18:46 Justice is that this is a segue, but your preferred version of vitamin B, which is sometimes needed to lower homocysteine to the optimal. 18:58 Well, of course we need B complex, but with regard to vitamin B12, it's always nature's form, which is hydroxylcobalamin, 19:05 never methylcobilamin never acetylcabolamin. 19:08 Never other things, cobalamins. 19:12 It turns out it is fairly easy to pharmacologically and negatively influence methylation. 19:20 Methylcobalamin causes hypermethylation. 19:22 That means too much methylation. 19:24 So always nature's form, always hydroxo, never a mixture of different B12 forms, that's just a gimmick. 19:33 So nature's form of B12, hydroxocobalamin. 19:36 Thank you. 19:37 What do I recommend? 19:38 Hydroxo-cobolamin and we, again, we have little dots that go under the tongue and get dissolved before swallowing to go to the brain first and then the 19:49 body and to get adequate B-12 and B complex. 19:52 That'll get a few people to scratch their head because they go look at their B complex and it may not be hydroxyl B12, but take a look. 19:59 It's out there. 20:00 Of course, PERC makes the optimal formulations. 20:04 What about one that's a little trickier to get from your primary care doc in omega-3 index, but it is available at Quest and LabCorp. 20:13 I find the hospital labs do not run it right. 20:16 They don't offer it. 20:18 So again, I would refer people to the two big national labs, Quest, and lab corp. 20:23 What's the optimal result we'd like for health and longevity as a biomarker? 20:29 Right. 20:29 More than 8%, according to Bill Harris, who developed the Omega 3 index, is desirable. 20:36 I happened to measure in at 13.4. So I called up Bill Harrison. 20:41 And I said, it's 13 point four better than eight. 20:45 He says, we don't have enough people up at your level to know, but we think that's better. 20:49 So definitely more than 8%. We take in too much omega-6 by a lot and too little omega 3 by too. 20:56 Little. 20:57 Right. 20:57 We want to up the omega three. 20:59 It usually means supplements. 21:04 Right. 21:04 You can eat your chia and your ground flax and you're walnuts and greens. 21:09 And you can take vegan algae based omega-3 supplements. 21:13 Of course, there are very pure fish based, anchovy based grill based Omega- 3 supplements, but it's probably going to require something beyond an average diet. 21:23 I find again that the single most common nutritional deficiency in my patients is extremely low Omega 3. Nobody gets taught. 21:32 You need it, you don't make it. 21:33 You better find a source one way or another. 21:35 Okay, let's get exotic. 21:38 Just to put a very important point in, the omega-3 supplement must be distilled under nitrogen to remove harmful ingredients and to protect the Omega- 3 21:50 from damage, from oxidation. 21:52 So most omega-3 supplements are damaged because they're produced in air. 21:57 It's much cheaper. 21:59 it's hard, it is actually pharmaceutical quality to distill under nitrogen to get the highest concentration omega 3 with the minimum amount of toxic metals. 22:11 Let's do the last three of the big eight and one or two more questions. 22:14 One that's simple to do. 22:16 First morning urine pH, pee in a cup, a pH test strip, get a result. 22:22 Anybody can do it. 22:23 Of course you sell the test strips at perc.com. 22:26 They're very inexpensive. 22:28 What does that tell us and what's the optimal result? 22:31 The optimal results is a urine pH of 6.5 to 7. 5. If you're below 6 point 5 you are too acidic and you need more magnesium and choline citrate. 22:41 if you above 7 point five consistently you might have catabolic illness and we should reverse the tearing down of the body by catabolic illness. 22:51 So again, the Goldilocks scenario, 6.5 to 7. 5, you increase magnesium and choline citrate if you're below that, and you reverse catabolic illness if your 23:00 above that. 23:02 And I will say if for reasons your doctor orders a simple your analysis and it happens to be your morning urine, it does report the pH, 23:10 but you can do this test at home. 23:12 Maybe the first one we go this, you must do that. 23:14 At home on a fresh urine. 23:16 If you take a urine and bring it to the lab and let them analyze it, the chances are overwhelming. 23:25 The chances of their overwhelming that the ph will be off. 23:31 Because bugs are growing and things are changing and metabolism occurs. 23:35 The reason that we recommend a less than a dollar a day test, which you do yourself fresh. 23:44 That's accurate. 23:46 We used to teach people at NIH how to measure their urine fresh, not even send it to the lab which took half an hour. 23:56 You'd be surprised how much change in metabolism can occur. 23:59 You want to do a urine pH fresh. 24:03 you either pee on the strip or better, more aesthetically pleasing, you pee in a dry cup and then you quickly put the drip in and measure it. 24:12 And then I recommend you keep a log of what your daily urine pH is and how you're feeling. 24:18 And you will probably notice that you feel better the days when your pH 6.5 to 7. 5 and the day is when it's below or above that, 24:27 you'll feel worse. 24:28 Interesting. 24:29 That confirms that nature's alkaline way really works. 24:35 You use that term, but I want to remind the audience, there's a wonderful ebook you have at perc.com and drrusslejaffee. 24:42 com called The Alkaline Way. 24:44 I've read it, I would highly recommend it. 24:47 For sake of efficiency, we've got two more biomarkers for health and longevity. 24:53 Uh, they're a little more sophisticated and I want to give people the chance to study them. 24:57 They're on your website, the Oxyguanine and the, I wanna give it to Elisa. 25:03 And I wanted you to read that a bit more challenging to find them, but if I can ask you, sir, for example, Questlab offers a urine test called isoprostanes. 25:13 widely available as a marker of oxidative stress. 25:17 Do you find that interchangeable with oxoguanine or there's something unique?
CoQ10, Antioxidants, and Heart Repair 25:21 No, it's not interchangeble. 25:23 Curiously, in the 1970s, I did work with rhomboxanes and isoprostanes in our animal models of heart disease. 25:32 I'm quite familiar with the difference. 25:36 Isoprosthanes come from fatty acids. 25:39 They're a reflection of your omega-3 to omega 6 balance. 25:43 Isoprostanes are interesting, but they do not tell you whether your DNA is being oxidatively damaged or not. 25:52 Whatever they are, they don't tell about that. 25:55 The 8-oxoguanine test is a urine test that tells you about damage to the DNA. 26:01 It also tells that you might need more ascorbate and magnesium to protect the dna, But it's specific for DNA Whereas isoprostanes are a global measure 26:14 of how your fatty acids are metabolized. 26:17 And they're interesting, especially to me who's interested in cardiovascular disease, but they don't tell you about the nucleus. 26:24 I want to get to two we've chatted before, about you have a lot of people listening. 26:30 Are taking supplements and some aren't, and a lot are taking CoQ10, Coenzyme Q10 as a cardiovascular, maybe general health support supplement. 26:40 You have some comments to say about whether you seek out ubiquinol or the more widely available Ubiquinone, the standard Coq10 you might find in a big 26:52 box store, but many vitamin companies. 26:54 So tell us why ubiquinal is superior in your opinion. 26:59 Well, what you want is CoQ10 the way Falkers recommended it, which means micellized in 100% rice bran oil. 27:10 It turns out rice brand oil is unusual, it's a little expensive, but it keeps Coq10 available to come into the body. 27:19 If you want to think about CoQ10, think of the Librea Tar Pits. 27:24 Think about something that's very thick and viscous and not very soluble. 27:30 Most Coq10 is a placebo. 27:36 most Co Q10 doesn't really get into the body. 27:38 Right. 27:40 Of course. 27:40 If you want CoQ10 to get into the body, you must micellize it in 100% rice bran oil. 27:48 I actually combine Coq10 with ticoferol, vitamin E, because if you need Co210, then you probably need vitamin e. 27:56 Where do you meet it? 27:59 In the mitochondrial battery of the cell. 28:02 This is very important. 28:04 Detoxification occurs because of CoQ10, and when Coq10 is low, detoxification doesn't happen as well. 28:11 Co Q10 10 is necessary to shuttle the electrons that produce the ATP, which is the work molecule of the body. 28:18 So we want ATP. 28:21 But we get with the ATP one proton, one acid molecule that gets pushed out of the mitochondria into the cytoplasm. 28:29 And if there's plenty of magnesium to buffer that, it's okay. 28:34 But if the acid continues to build up and magnesium is not there to mitigate it, to reverse it. 28:42 The proton gradient, that's a little complicated, but the proton grading is what keeps the battery alive and working. 28:50 The proton gradient collapses. 28:52 The mitochondria goes to sleep to protect itself. 28:56 And now you're left with what's called Emden-Meierhoff or sugar metabolism, which will get you to survival, but not to thrive. 29:05 And I, again, urge people to go over. 29:08 You do make a very fine product. 29:10 I use Perk MitoGuard. 29:12 That is the form of CoQ10 with the proper form vitamin E and vitamin A you were just referencing because you've done your work. 29:20 So let's shift to maybe the last bullseye here. 29:23 Talking about, again, reverse your heart disease naturally. 29:27 We're a plant forward group here, what top nutrient or nutrients in your opinion should always be part of a toolbox for a healthy heart? 29:39 A toolbox or a health heart starts with ascorbate. 29:41 You might need other antioxidants, but you definitely need ascorbate, nature's form. 29:49 Then you need B complex, all the B's, balanced Bs. 29:53 Beatrice Trump Hunter taught us this 40 years ago. 29:58 In addition to balanced bees, you might need more B12 or B6 or thiamin. 30:05 Now you can do functional tests of each of these nutrients. 30:11 I'm not going to get into that right now, but that you can document that people need more B12, B6, thiamine, niacin, whatever, 30:21 folate. 30:23 I am a big fan of ascorbate, E-complex, and cofactors like CoQ10. 30:31 Adequate to reach, restore, to rehabilitate the levels in the body, because today We're under assault from lots of toxins that deplete the antioxidants, 30:44 the buffering minerals, and the cofactors. 30:46 They get depleted. 30:48 So we have to up the good and decrease the bad. 30:52 That's provocative. 30:54 I think it'll really interest people. 30:56 Your view on the role of the molecule cholesterol in atherosclerosis. 31:01 Cause, innocent bystander. 31:04 Where's your take as a very, very bright man on that? 31:08 Well, let's start with what most people believe, which is what Don Fredrickson taught when he was director of NIH, Which was the diet heart hypothesis. 31:19 The amount of saturated fat or the amount cholesterol that you ate influenced your blood cholesterol and triglyceride levels. 31:29 Except when people changed their lifestyle, their lipids changed. 31:35 So the diet heart hypothesis, which assumed a genetic cause for hypercholesterolemia, turns out to be profoundly out of date and incorrect. 31:46 And most of the rest of world has given up on this idea, but Don Fredrickson kept it alive. 31:51 Now I worked with Don Fry, Bob Mailey, and the three of us redefined heart disease in the late 70s. 31:59 Bob Maley coined the term lipoprotein, so he's kind of important in regard to blood fats. 32:06 Don Fry is the guy who showed that at bifurcation points in blood vessels, turbulence occurs when blood pressure goes up and atherosclerosis is accelerated. 32:15 That was Don fry. 32:17 My role was to show that changes in the blood clotting predicted heart disease years to decades before the catastrophe. 32:26 And what caused platelets to be too reactive? 32:28 A lack of vitamin C, a lack magnesium, lack essentials, and too much oxidative stress. 32:33 Too much. 32:34 Now we studied foxhound dogs. 32:37 We studied eucatan pigs. 32:40 Why? 32:41 Because the studies we were doing required animals, not human animals. 32:47 study animals. 32:48 It turns out that foxhounds don't get atherosclerosis, and so if you find it, you did it to them. 32:54 And Yucatan pigs have a cardiovascular system very much like people, having nothing to do with the pig, it just happens to have cardiovascular systems 33:02 that's very similar to a human. 33:04 They do get spontaneous athroscleroses. 33:07 We showed that cholesterol didn't matter.
Cholesterol, Oxidized Lipids, and the Path to Thriving 33:10 But oxidized cholesterol, a small amount of oxidize cholesterol buried in your total cholesterol will kill you. 33:17 So we pay a lot of attention to antioxidants to prevent oxidized cholesterol from forming. 33:23 It turns out that magnesium is an antioxidant that protects essential fats in transit. 33:28 And if you don't have enough magnesium, your essential facts get oxidised, which means damaged. 33:35 Then they become atherogenic. 33:37 Only when they're damaged do they becomes harmful. 33:40 So the notion of cholesterol at 200 or LDL at 100, they are easy numbers to remember. 33:46 They're using numbers to teach. 33:48 They have almost nothing to do with atherosclerosis. 33:53 Half the heart attacks occur with people below 200 cholesterol, half the hearts occur to people above 200. So what's magical about 200? It turns out that 34:02 cholesterol is easy to measure. 34:04 We've been measuring it for half a century or more. 34:08 But what is important is to measure the oxidized cholesterol, which almost never gets measured. 34:12 And if the oxidation cholesterol is zero, Which it should be if you're taking in enough antioxidants and not too much heavy metals and toxic metals, 34:20 your oxidize cholesterol will be zero. 34:23 and that means your risk of atherosclerosis will less. 34:26 Then I want you to be in repair mode. 34:28 I wants your collagen and elastin to get repaired. 34:30 i want your basement membrane to Get repaired, I Want yourselves to Be energetic and able to detoxify. 34:39 Conventional medicine doesn't pay enough attention to cause. 34:43 Convention medicine is so occupied with fighting with the symptoms and suppressing and reversing the symptom of ill health that The reason we started the 34:55 PIH Academy was to get doctors to understand cause, not consequence. 34:59 I think we have covered just some phenomenal ground. 35:03 You've written incredibly insightful books. 35:06 Again, the title of your newest book, I have it sitting next to me. 35:09 Right, Thriving in the 21st Century. 35:11 We want you to thrive in... 35:13 Yeah, and a lot of what we've talked about, there's more depth, but I found it a very readable book and would recommend it to everybody. 35:21 And the two websites where people can go deep on biomarkers and tests and supplements are which two? 35:28 Yes, PERQ, P-E-R-Q-U- E, perq.com, p-e-r-q-u- e. 35:32 com, and then drrusslejaffe. 35:36 You have to put in drrusslejaffe.com because Russell Jaffe is a poet and I am not. 35:42 But Dr. 35:43 Russell, Jaffee will get me on YouTube. 35:45 We have a website that presents this information in accessible forms, both for consumers and for professionals. 35:53 So I hope today has been an appetizer. 35:56 I hoped today had been of interest and therefore you will dig more deeply to prove that this is true. 36:04 I think that's a great term. 36:05 It is indeed an appetizer because it would require, you know, literally hours and hours. 36:10 But this has been great. 36:11 So thank you for your time and your education and you're really unique background and experience. 36:17 I Think we have upgraded the health of a lot of people and they're going to go over to perc.com and learn more. 36:22 A lot a urine checkers are going come out of this. 36:27 All good. 36:28 The more we can know about ourselves, the more preventive and proactive attention. 36:37 When I'm concerned, I am concerned mostly about me. 36:41 I want people to know about themselves and then share the good news that together, you and I can speed the transition from sick care to healthful caring. 36:51 We can look at the causes, not just the consequences, and we can avoid the catastrophes. 36:58 All right, we'll leave it at that and have a tremendous day. 37:01 You've shared so much. 37:03 Thank you for tuning into Dr. 37:05 Talks. 37:05 We hope today's episode has enlightened and inspired you on your path to optimal health. 37:10 Each day is a new opportunity to make choices that empower your well-being. 37:15 For more insights and strategies, subscribe to our podcast and visit our website, www.DrTalks .com. 37:24 Stay connected, stay healthy, and join us next time on Doctor Talks, real talks from real doctors on the issues that matter to you most.
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