Spermidine UNLOCKED: Reverse Aging, Boost Immunity & Thrive After 40 l Leslie Kenny l Ep #420

🔹 About This Episode:

In this mind-blowing episode of The Longevity Podcast, I sit down with pioneering mitochondrial scientist Dr. Natalie Yivgi-Ohana to explore the incredible science behind mitochondria—the tiny cellular powerhouses that control energy production, hormone signaling, immune function, and the aging process itself. We dive into the fascinating origins of mitochondria through the endosymbiotic theory, why they are inherited from our mothers, and how mitochondrial dysfunction is now linked to many of today’s biggest health challenges, including chronic disease, neurodegeneration, metabolic disorders, and infertility.

Dr. Yivgi-Ohana also reveals groundbreaking advances in mitochondrial medicine, including mitochondrial transfer and mitochondrial transplantation, therapies that may transform the treatment of rare diseases and potentially age-related conditions. We explore mitochondrial biomarkers, metabolic flexibility, stem cell exhaustion, mitochondrial-immune communication, and lifestyle strategies to protect your cellular energy systems. If you want to understand how mitochondrial health influences longevity, vitality, and resilience, this conversation uncovers the science shaping the future of medicine.

Leslie has a generous offer for you, when you visit oxfordhealthspan.com/BIONAT20 and use code BIONAT20 at checkout you’ll get 20% off.

🔹 What you will learn:

→ Why biological age matters more than chronological age — and how inflammation, immune resilience, and lifestyle choices determine how fast your body actually ages.
→ How spermidine activates autophagy, your body’s powerful cellular clean-up system that removes damaged cells, supports mitochondrial health, and promotes longevity.
→ Why common longevity practices can backfire for stressed or autoimmune-prone individuals — plus practical strategies to optimize thyroid health, diet, fasting, and daily habits for healthy aging.

🔹 What We Discuss:

Welcome, show intro, and overview … 00:00:00
Leslie Kenny’s health journey and reversing disease … 00:00:30
Biological vs. chronological age and the immune system … 00:04:55
Impact of trauma and stress on aging … 00:11:51
Overcoming prognosis: lifestyle and scientific interventions … 00:18:02
Diet, tracking, and removing triggers … 00:22:21
The overlooked importance of thyroid health … 00:32:23
Dangers of overdoing fasting and hormesis … 00:40:21
Autophagy basics and the cellular cleanup crew … 00:44:06
Spermidine’s role, sourcing, and supplement quality … 01:10:19
Optimizing longevity habits and daily routines … 01:29:44

🔹 References:

• Go to https://www.natniddam.com/podcast/k8l3xquze0a3gudprlsv0ti3w6ezl0 and check the description

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🔹 Learn More From Leslie Kenny below:

• Website: http://oxfordhealthspan.com/BIONAT20
• Instagram: https://www.instagram.com/oxfordhealthspan/

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🔹 Thank You To Our Sponsors For Making This Episode Possible:

• Tro Zzz by Troscriptions – A fast-acting sleep troche that dissolves in your cheek and combines melatonin with compounds like honokiol, adenosine, cordycepin, CBD, CBN, and 5-HTP to support deep, restorative sleep when travel, stress, or late workouts throw things off. Head to https://troscriptions.com/?rfsn=6675818.a3231d&utm_source=refersion&utm_medium=affiliate&utm_campaign=6675818.a3231d and use code NAT10 for 10% off your first order.

• BEAM Minerals – Low energy often starts in the mitochondria. Support cellular energy with a bioavailable liquid mineral supplement — and get 20% off at http://www.beamminerals.com/NAT20 with code NAT20.

• Nature’s Marvels Bioregulators – provide gentle, organ-specific support — and the Liver Bioregulator is a favorite this season for supporting detox pathways and metabolic flow. Head to https://profound-health.com/?Aff=Longevity15 and use code NAT15 for 15% off your first order.

🔹 Find more from Nathalie:

• Join Nat’s Membership Community: https://www.natniddam.com/the-longevity-community
• Sign up for Nats Newsletter: https://landing.mailerlite.com/webfor…
• Instagram: https://www.instagram.com/nathalieniddam/
• Website: https://www.natniddam.com
• Dr. Bill Lawrence Episode: https://www.youtube.com/watch?v=jr2rcC1lNyM

#TheLongevityPodcast #Longevity #Spermidine #Autophagy #Biohacking #HealthyAging #ImmuneHealth #CellularHealth #ReverseAging #NathalieNiddam