What I Tell My Patients About PEA for Chronic Pain Relief (Palmitoylethanolamide)
Naturopathic Medical Doctor
If you have chronic pain, joint pain, nerve pain, or migraines, there is one natural compound backed by over a dozen clinical trials you need to know about.
This video explains the science behind PEA, a natural pain-relieving compound shown in clinical trials to reduce chronic pain, nerve pain, joint pain, and even migraines. Learn how it works, what dosages were used in research, and how it compares to common over-the-counter and prescription pain medications. If you or someone you know struggles with persistent pain, this supplement may be worth exploring with your healthcare provider.
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CHAPTERS
00:00 The Problem With Common Pain Medications
00:41 What Is PEA and Where Does It Come From
01:05 PEA as a Broad Spectrum Pain Reliever
01:27 Clinical Trial Results Across Multiple Pain Types
01:59 PEA for Joint Pain and Nerve Pain
03:12 Can PEA Help With Migraines
03:56 Safety Profile and Long Term Research
04:33 Recommended Dosages and Combining With Other Supplements
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✅ About Dr. Mark Stengler.
Welcome to my natural health channel, Dr. Mark Stengler! I’m Dr. Mark, a Naturopathic Medical Doctor and best-selling author with nearly 30 years of experience in integrative medicine. Here, I share expert insights on natural health, nutrition, and the power of integrative medicine—blending conventional and holistic approaches to achieve optimal wellness.
Honored as the 2021 Doctor of the Decade by the International Association of Top Professionals and a former advisor for Yale’s Complementary Medicine Outcomes Research Project, I will guide you on your health journey with trusted advice and evidence-based natural therapies.
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MEDICAL DISCLAIMER: This video is for general information and educational purposes only and does not constitute the practice of medicine, the giving of medical advice, or the establishment of a doctor-patient relationship. The information provided is NOT intended to be a substitute for professional medical advice, diagnosis, or treatment, and is NOT intended to treat, diagnose, cure, or prevent any disease or medical condition. Always seek the guidance of your physician or qualified healthcare provider with any questions you may have regarding a medical condition. Do not delay or disregard seeking professional medical advice based on anything contained in this video. Do not make any changes to your health regimen, medications, or supplements without first consulting your physician or healthcare provider. Dr. Mark Stengler assumes no liability for any direct or indirect losses, damages, or adverse outcomes that may result from use of the information in this video. All content is provided for educational purposes only and is subject to change without notice.
Full Transcript
Introduction to PEA for Pain Relief 0:00
Are you suffering from pain, chronic pain? And you're looking for natural ways to relieve your pain. Well, as you watch this video, I'm going to go through a breakthrough in the natural product industry for a supplement known as PEA. So as watch the video you are going understand the science behind PEAs and why it's really a valid way to help to decrease your levels. You know, so many people have problems with chronic pain, sciatica, low back pain neck pain. Various reasons why people had pain and millions of Americans resort to using non-steroidal anti-inflammatory drugs, you know the ibuprofen, the Tylenol.
Then there's the prescription medications, especially the opioid family. And we all know what a problem that has been for addiction and even death for so much people. But what do we have in the natural products, in a natural supplements, which is really effective for pain? Yes, we have things like bromelain. We have turmeric, which is decent. But really the best by far, in my opinion, is PEA.
What PEA Is and How It Works 0:48
And PE A stands for palmitoyl ethanolamide. This is a natural substance, a national agent you find in foods like egg yolks, for example. You find it in soy lecithin, albeit in very small amounts. but you can concentrate it and take it into supplement form. The studies on PE are quite amazing and there's many of them. So let's go over the things that PE can do for you. First of all, PA is known as a broad-spectrum analgesic, so it has a general pain-relieving effect. More than that, it's also anti-inflammatory.
In addition, its neuroprotective. It helps to not only relieve nerve pain, but protect the nerves from damage. randomized controlled trials or well-designed studies. Patients had different types of pain that they studied. They had gynecological pain, say like menstrual cramps, neurological pain so nerve pain pain of the muscles and skeleton, and also irritable bowel syndrome where you get that abdominal cramping type of paint.
Clinical Evidence for General and Joint Pain 1:44
And what they found in nine of 11 studies was that TA had significant pain relieving effects. Now in those studies, the dosage that was used ranges between 300 to 1200 milligrams daily. Also, PA has good studies on for joint pain. In 2021, they did a randomized double blind study comparing 350 milligrams of a type of PA product compared to placebo for reducing joint and adults. And in this two week study, They found that the pain scores were significantly reduced in taking PEA versus placebo. So definitely it's a supplement you should use if you're having more than mild joint Now, nerve pain, I've mentioned before, and they've done eight clinical trials involving over 1300 people, And they found that PA was safe and effective for treating sciatica pain low back pain and carpal tunnel syndrome.
And let's face it, those of us in clinical practice, we know those conditions can be difficult to treat. In addition, they did a study of 636 patients who had sciatic. and they used doses of 300-600 mg of PEA and compared it to placebo.
PEA for Nerve Pain and Sciatica 2:44
And after three weeks, those who took the PEAs at 600 mg a day had a 60% reduction in their pain levels. Well, I hope you're enjoying the video. If you are looking for quality supplements, go to my website drstengler.com and there you can see the nutritional supplements I've been using with my patients for many decades. They involve a lot of scientific research. Many of them I have created myself. So again, thank you for watching the Well, how about migraine headaches? That's certainly a type of pain.
And migrain headaches are difficult to treat sometimes with natural products. But PA did very well. In 2022, they did a double blind study comparing PA to placebo for adults with migraines. So at the start of a migrane, when a Migraine was coming on, the participants took the PA at 600 mg or placebo. and then they record their pain scale every 30 minutes for four hours or until the migraine went away.
PEA for Migraine Headaches 3:34
If the Migraine had not resolved at the two-hour mark, then a second dose was given. So what they found was those who took the PA resolved more headaches, had a lower pain score, and reduced the need for acute migraines medication more significantly than placebo. Again, that's really putting it to the test when you can help migrain headaches. Now, what about the safety of PEA? Because when you look at pain relieving products, especially the pharmaceutical drugs, obviously they have problems for liver toxicity, kidney toxicity can create heart problems, clotting problems.
But PEAs very safe. Matter of fact, over 50 years, the size has shown up to 1200 milligrams a day really does not have any harmful effects. In one study, the researchers stated the following, quote, numerous clinical trials involving more than 1500 subjects have demonstrated no adverse effects with doses of 300 to 1200 milligrams per day being studied extensively in both healthy and sick populations.
Safety, Dosage, and Final Recommendations 4:24
So anyways, PA is very safe and it's quite effective. I use it a lot with my patients. For those with acute and chronic pain, I'll use PA around 600 milligrams a day up to 1,200 milligrams today. That's more acute, serious type pain. Sometimes I'll combine it with a highly absorbable turmeric product as well. That's a nice synergistic combination. In any event, if you're suffering from pain, talk to your health care provider about the use of PEA. It really is quite a breakthrough in the natural product industry.
For more videos on terms of chronic health disease, acute health problems, problems with pain. See more video on my YouTube channel.
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