Full Transcript Intro to Genetics and Metabolism 0:00 I think most women over 40, you're going to have a higher cortisol response when you are like running 4,000 miles a week. 0:07 But you know, we look at particular genes and we did talk about this on a previous episode, but genes like A, D, R, B2 and B3, 0:15 they govern fat cell response to exercise signals. 0:18 So impaired variants here mean that breakdown doesn't respond well to adrenaline even during intense exercises. 0:24 Welcome to Beyond the Scale, where real health gets deeper than just the numbers. 0:29 I'm Dr. 0:30 Darren Dubiak. 0:30 And I am Alexandra Dubyak, and we are not only partners in life, but also passionate partners and integrative care. 0:37 Blending faith, family, functional wellness, And a little life with our dogs. 0:41 Because true healing happens beyond the scale. 0:46 All right, guys. 0:47 Welcome back to Beyond the Scale. 0:49 Again, I have Dr. 0:50 Piper Gibson, who is joining us today. 0:52 If you guys have been following us on Beyond The Scale, we know that we have done this series on the Aimprint, and the aimprint is the genetic testing 1:04 that is offered here at Body By Aim 360. Dr. 1:06 Gibson in her own right, I will say is a genius in the genetic world, right? 1:11 She's a great educator. 1:12 She has been teaching this for many, many years. 1:15 And Dr Gibson and I have two different client bases, we were just talking about this off air where You know, body, my aim 360. And so what Allie and I do, 1:25 it's very metabolic and hormone facing, right? 1:28 So Dr. 1:29 Gibson, again, tell people what you specialize in for your clients, especially in the genetic testing room, please.
Meet Dr. Piper Gibson and the Aimprint 1:36 Yeah, so I specialize in working with children and families whose children struggle with things like anxiety, ADHD, OCD, 1:43 with a very specific specialization in tick disorders and Tourette's. 1:47 And so we're looking at these neurological syndromes with kids that are really not truly neurological. 1:53 So you and I look at some similar genes, but I'm looking a totally different set of genes for a different reason when I am looking to genetics for my clientele. 2:02 Gotcha. 2:03 And then you know, guys, how Dr. 2:05 Piper and I met is through mutual friends and mutual colleagues where they say, listen, you guys are really, really forming the structure of genetic testings 2:14 in the country. 2:15 How much more can we educate? 2:16 And I think there's so many, and, I talk about it on every episode. 2:20 So many celebrities pushing so things, right? 2:24 What's right for me, what's for my clients? 2:26 I'm telling you, being a client of my own company and going through the same print, it was really life-changing for me. 2:34 So let's get into the fun one. 2:38 What's Aimprint? 2:39 Dr. 2:39 Gibson, we already did the top 10 genes that we look out on Aim print. 2:45 Let's go over this. 2:47 Why do diets keep failing you? 2:52 I mean, this is the million dollar episode. 2:56 If everyone, this is the million dollar episode. 3:00 And you know, I always tell people anymore, they're failing because it may be genetic. 3:05 Don't you agree? 3:06 I totally agree. 3:07 They're not following the right diet for their genes and it makes a difference. 3:12 And that's where I go back to. 3:13 You know, you have celebrity one or even this person that it's the next hot thing, like should I, go high, high fat, low fat? 3:23 Nothing but animal organs and blah, blah. 3:25 But, nobody knows. 3:27 But do we know? 3:29 And that's why this genetic test is so important. 3:31 So listen, I want to get right into it. 3:33 I wanna go carb and fat-tolerant. 3:36 More or less, why does keto work for some and backfire for others?
Why Diets Fail for Different Genes 3:40 Yeah, and this is where we are using your genetic panel as a blueprint, as our roadmap to map this out. 3:47 One of the things that I think is going to be a great reference is for people to go back and listen to the previous episode where we talk about like the 10 3:53 top genes on your test. 3:55 But let's look at some examples. 3:56 So example, FTO genes, we know that people who have this homozygous variant, so on you test panel, it's red, its bright red. 4:04 It's like, oh, stop right there. 4:06 So when we have those variants on this panel, it really looks at people who are going to benefit more from a low carb diet. 4:16 So we know this high carb, they're just going have this harder problem with these high carbs. 4:20 For this person with an FTO variant, low carbs is going be better. 4:24 But there's multiple genes that you are looking at on the panel. 4:27 We know somebody who might have a red, A, C, S, L, five, this indicates the inability to metabolize- Say that five times very quick, 4:39 yes. 4:40 I know, right? 4:41 This really kind of reduces our ability to metabolism fat for energy. 4:45 So someone who has this variant as like, oh, I'm going to do the keto diet, their body may struggle to use the fat as fuel efficiently, 4:52 leading to things like fatigue, brain fog, and poor adherence. 4:55 And so Yes, we can look at these genes and what your response is going to be to a lower carb diet or a keto diet. 5:02 And we really want to find the sweet spot for these people between both. 5:07 Yeah. 5:08 You know, and you're right. 5:09 Like, you know we talked off air of how horrible I felt on keto, right? 5:14 But we saw as soon as I gave myself a little bit of carbs, I fell fantastic. 5:20 And having my own test on myself, it was eye opening because I am that person. 5:26 I'm that. 5:27 you know, fat, protein, a little bit more carbs. 5:29 So talking about that, the mixed macronutrient result, like what's that look like clinically, you now, in a pie chart? 5:38 Yes. 5:38 So that, and that's kind of one of the cool things that we can look at is those percentages. 5:42 And so when we're looking at, so for this particular patient, for example, you know, they have a 48% response on their high carb and they had a 55 response 5:52 in their low carb. 5:53 We can see like they're better for low-carb, just a little bit lower for the high- carb And then, but neither run high, we know that their fat response 6:01 is quite a bit lower, it's 33%. So what does that look like? 6:04 We want to do moderate carbs at about 40%, moderate fat at 30%, higher protein. 6:10 It's not an extreme diet, But this person is failing diets because every popular diet pushed them to the extreme that they're genetics are not supporting. 6:19 And so that's really the core value of the Aimprint is it is removing that guesswork from that dietary structure. 6:24 Yeah, and I love it. 6:25 And that makes sense because so many people think, one, they think if it's, if they have to go all in or nothing. 6:31 If they don't go in all or anything, then they'll fail.
Fasting Response and Genetic Fit 6:34 Right? 6:34 And I see so much times that's just not the case. 6:37 You know, we made a name for ourselves at Body by Aim and the aim method for doing these things, getting the right foods for you. 6:46 Now, not only from a blood work standpoint, but also genetically. 6:49 Next, I want to get into something that actually helps me significantly, right? 6:54 And I found out why because genetically I scored very high for it, which is the fasting response. 7:00 So is fasting actually backed by genetics or is it a one-size-fits-all? 7:07 It really can be backed by genetics. 7:10 It's not necessarily a one size fits all. 7:12 I also think it's just not your genetics, but I think age and sex matters, like if you're female or male. 7:17 But when we are looking at this, things like PPARA is, if have a normal, it is in the green, this is a natural, normal metabolic adaptation for using fat 7:28 as fuel. 7:29 and during fasting. 7:31 So, you know, it really kind of lends a green light to that concept. 7:34 But when we go back to the ATSL5 gene, good lord, It creates friction in fat metabolism. 7:41 These two findings together really suggest to us fasting could help, but it needs to be done slowly because we have to adapt. 7:49 So, you know, if you're incorporating fasting, considering doing it gradually, we can look at these two genes and then have a plan. 7:55 So instead of just one day being like, I'm going to fast for 15 hours, genetically, it may not work out for you. 8:02 And it maybe that you need to increase that gradually over time. 8:05 Absolutely. 8:05 And you know, Dr. 8:06 Gibson, there's definitely doctors, you and I, I know we're part of corporations, in part, what do you want to call it? 8:14 I guess, advanced testing where we have a lot of peers and a lots of pioneers in that fasting role. 8:20 I always just say, it can't be all or nothing. 8:22 There has to be a way of going into it. 8:25 The AIM prank finally proved that, so I appreciate that. 8:29 Appetite and craving.
Appetite, Cravings, and Satiety Genes 8:30 So what happens when multiple genes are impaired or just not working? 8:38 Right. 8:39 Again, we're looking at this layering concept of how these genes all functioning together. 8:44 For our make-believe person today, there's a gene called HTR2C. 8:50 This is where we have serotonin receptors that are less responsive. 8:54 Reducing our fullness signaling. 8:56 and then we have an LEP gene that can really look at slightly lower leptin production. 9:03 And then the leper gene or LepR, this is your lepton receptor gene, and this can be less responsive even to what is produced. 9:11 So when we look these independent variants and these issues that are going on in the satiety system, This person is not overeating because of lack of discipline. 9:21 Their biological fullness signaling is genuinely muffled at multiple levels. 9:26 It's like, yeah, so clinically this changes everything. 9:29 We know for somebody like this, high protein, hi fiber, structured meal timing, targeted supplements all become therapeutically necessary. 9:37 it's not just a nice to have. 9:39 So now you have these genes that we can look at how they work together, how are they functioning within the body. 9:44 And then we consign this really individual diet plan. 9:48 Gotcha. 9:49 Last but not least, and I want to come back to all four of these again, but when we know why diets may be failing us, it's certain reasons. 9:57 And one of the big reasons I'd always tell people is you have to think there has to be over 300 or 400 types of different exercises, 10:03 right? 10:03 You could do from riding bikes to swimming to anything. 10:07 I used to often be stalled by patients, I would pay a million dollars. 10:11 if I knew exactly what exercise was right for Darren to do, right? 10:16 And why would you not then spend all your time and effort in doing that? 10:19 So now there's the aim print. 10:21 And with the Aimprint, there is an exercise response gene. 10:25 So why do some people lose nothing from exercise despite working harder and harder at it? 10:33 And I see that a lot in my practice, Viper, where especially some of my women over 40 are like, I've been running three miles every day for the past seven years. 10:42 I'm actually gaining weight, Darren. 10:44 You know, why? 10:46 Well, one, we have to look at cortisol response and that. 10:49 And, and I think most women, over forty, you're going to have a higher cortisol respond when you are, like running four thousand miles a week.
Exercise Response and Fat Loss 10:57 But, you know, we look at particular genes and we did talk about this on a previous episode, but genes like A, D, R, B2, 11:03 and B3, they govern fat cell response to exercise signals. 11:07 So impaired variants here mean that breakdown doesn't respond well to adrenaline even during intense exercises. 11:14 So if this person is in the red, it can also impact their blood lipid levels and their cholesterol. 11:21 And so exercise being essential for patients' fat loss and mood, but diet being a primary lever when we're looking at things like cholesterol, 11:29 so. 11:30 Exercise can help so many different things, but when we're looking at these particular genetics, it can helps us design that perfect workout plan. 11:37 Should you be doing a HIIT exercise, or would you better off doing moderate exercises over a longer period of time? 11:45 So when you can look at that genetics it's going to help us narrow down what your real exercise plan should be. 11:51 And again, with working with our health coaches and the AIM method and and they metabolic reset protocol or food program that we have our patients. 12:00 Again, having the information from a genetic standpoint is imperative for just not us helping you, but for you for a lifetime. 12:08 You know, we actually were blessed to have a couple pro athletes to be patients of mine. 12:13 And right now we have, a young guy on the hockey team who's 26 years old, right? 12:19 And he is desperately constantly trying to gain weight. 12:22 I'll remember some of these guys by burning four to 6,000 calories per game, Right? 12:27 But for some reason this young gentleman, this pro athlete just cannot gain weight. 12:33 We did his genetic testing, his aim print a couple of weeks ago, and it was the biggest aha moment because it gave him an absolute roadmap. 12:41 Because remember, these guys are functioning at the highest capacity you can be at, right? 12:47 So from a standpoint of just not diets failing you from weight loss perspective, but also in gaining weight. 12:54 Like what is the perfect program, the Perfect genetic setup for that person on their food. 13:00 So I wanted to definitely put that into this episode because. 13:05 You know, yes, we are very large weight loss practice in the state of Pennsylvania, but I do have patients of mine coming in saying, 13:12 well, I just can't gain weight either, right? 13:14 And that's a big shift. 13:16 And we see from a genetic standpoint, after we analyze all the blood, there's lot of aha moments for us as practitioners, 13:23 you know? 13:24 There really isn't. 13:25 I just kind of mapped out something similar for one of my clients. 13:27 So I have a 17 year old client who wants to be a Navy SEAL and he is an athlete right now. 13:32 Baseball, football, all of the things. 13:34 And mom was just really stressed about how do we get enough calories and food into this kid? 13:39 And when you know the genetics, you are able to map it out.
Athletes, Weight Gain, and Personalized Plans 13:43 Exactly. 13:44 So she was so excited and she sent me this message and was like, oh my God, I was overwhelmed until I saw what you did for me. 13:50 I see this map and this makes it so much more doable. 13:54 This is exactly what this kid needs to be able to succeed. 13:59 And it was neat because the aha moment I had was, and it so great because this young man actually brought his mother to the appointment. 14:06 And you know, she says, well, that means he could eat whatever he wants then, right? 14:10 I mean, you're telling him he needs to eat three to five. 14:13 I'm like, not necessarily. 14:15 Right. 14:16 They got it when we really broke down some of these genomes. 14:20 And if funny enough, the mother actually even said who herself in her own right was a collegiate athlete in the eighties when she just said, 14:27 well, I actually, even had some of these issues. 14:30 So it was, it, was really neat dynamic. 14:33 Having mother and son and again, mother being a Collegiate Athlete and the son being, a pro athlete. 14:39 It was. 14:40 Really, really cool. 14:40 Was a great experience for us and for myself personally. 14:43 to treat them. 14:44 But listen to me, this was our third episode, right? 14:49 Our third video podcast in this series of the Aimprint. 14:54 The next episode is going to all be about genetic testing and medication and weight loss medication. 15:02 It's going be one of most incredible episodes. 15:05 I can't wait to get to it. 15:06 Next time, Dr. 15:07 Piper and I are going close out the aimprint series on that. 15:11 Listen, guys, thanks for following us. 15:13 If these items that Dr. 15:15 Gibson and I are talking about intrigue you or exciting, please call us, go to BodyByAim360.com. 15:23 Check out Dr Gibson in her practice. 15:26 She has been a great friend of Body By Aim and myself personally.
Closing Thoughts and Next Episode Preview 15:31 she is absolutely brilliant in this field of genetics and always humble for you to be on the show. 15:36 So I thank you so, so much. 15:38 And until next time guys. 15:40 We'll see you later. 15:41 Thank you. 15:42 Thanks for spending time with us on Beyond the Scale. 15:45 If today's episode helped you see your health differently, like the show, share it, and we'll see you next time on beyond the scale.
Comments