Full Transcript Peptides vs. Hormones 0:02 I want to address, cuz I know somebody's 0:02 I want to address, cuz I know somebody's going to ask, we're going to address it 0:03 going to ask, we're going to address it 0:03 going to ask, we're going to address it right now, the peptide gold rush and 0:07 right now, the peptide gold rush and 0:07 right now, the peptide gold rush and clarify the difference between a peptide 0:09 clarify the difference between a peptide 0:09 clarify the difference between a peptide and a hormone, because the terms are 0:11 and a hormone, because the terms are 0:11 and a hormone, because the terms are often used interchangeably. 0:13 often used interchangeably. 0:13 often used interchangeably. Now, a peptide is simply a short chain 0:16 Now, a peptide is simply a short chain 0:16 Now, a peptide is simply a short chain of amino acids. Remember protein, amino 0:19 of amino acids. Remember protein, amino 0:19 of amino acids. Remember protein, amino acid, peptide. 0:21 acid, peptide. 0:21 acid, peptide. Peptides can act as signaling molecules 0:23 Peptides can act as signaling molecules 0:23 Peptides can act as signaling molecules in the body, but not every peptide is a 0:27 in the body, but not every peptide is a 0:27 in the body, but not every peptide is a hormone. 0:28 hormone. 0:28 hormone. A hormone, remember, is that chemical 0:30 A hormone, remember, is that chemical 0:30 A hormone, remember, is that chemical messenger released by a gland or 0:33 messenger released by a gland or 0:33 messenger released by a gland or specialized tissue, and it travels 0:35 specialized tissue, and it travels 0:35 specialized tissue, and it travels through the body, and it changes the 0:37 through the body, and it changes the 0:37 through the body, and it changes the activity of another cell or organ. 0:40 activity of another cell or organ. 0:40 activity of another cell or organ. Some hormones are peptides. Insulin,
Examples of Peptide and Steroid Hormones 0:44 Some hormones are peptides. Insulin, 0:44 Some hormones are peptides. Insulin, glucagon, growth hormone, and GLP-1 are 0:47 glucagon, growth hormone, and GLP-1 are 0:48 glucagon, growth hormone, and GLP-1 are all peptide-based hormones. 0:51 all peptide-based hormones. 0:51 all peptide-based hormones. Other hormones, including your estrogen, 0:53 Other hormones, including your estrogen, 0:53 Other hormones, including your estrogen, progesterone, testosterone, and 0:54 progesterone, testosterone, and 0:54 progesterone, testosterone, and cortisol, they are steroid hormones, and 0:57 cortisol, they are steroid hormones, and 0:58 cortisol, they are steroid hormones, and they're made primarily from cholesterol. 1:02 they're made primarily from cholesterol. 1:02 they're made primarily from cholesterol. So, peptides are classified by what
FDA Peptide Advisory and Compounding 1:05 So, peptides are classified by what 1:05 So, peptides are classified by what they're made of, and hormones are 1:08 they're made of, and hormones are 1:08 they're made of, and hormones are classified by what they do. Now, you've 1:12 classified by what they do. Now, you've 1:12 classified by what they do. Now, you've recently heard that an FDA advisory 1:14 recently heard that an FDA advisory 1:14 recently heard that an FDA advisory committee recommended allowing certain 1:16 committee recommended allowing certain 1:16 committee recommended allowing certain peptides. A lot of anti-aging clinics 1:20 peptides. A lot of anti-aging clinics 1:20 peptides. A lot of anti-aging clinics and functional medicine, all these 1:21 and functional medicine, all these 1:21 and functional medicine, all these people have been doing BPC 157, TB 500, 1:25 people have been doing BPC 157, TB 500, 1:25 people have been doing BPC 157, TB 500, there's a bunch of them. 1:26 there's a bunch of them. 1:26 there's a bunch of them. Um and and so now everybody got cuz 1:29 Um and and so now everybody got cuz 1:29 Um and and so now everybody got cuz everybody was kind of flying in the 1:30 everybody was kind of flying in the 1:30 everybody was kind of flying in the gray. 1:31 gray. 1:31 gray. Now everybody got excited cuz they go, 1:33 Now everybody got excited cuz they go, 1:33 Now everybody got excited cuz they go, "Oh, the FDA just approved these 1:36 "Oh, the FDA just approved these 1:36 "Oh, the FDA just approved these peptides as medication." No, it did not. 1:39 peptides as medication." No, it did not. 1:39 peptides as medication." No, it did not. To be To be very clear, what the FDA 1:43 To be To be very clear, what the FDA 1:43 To be To be very clear, what the FDA recommended was allowing certain 1:45 recommended was allowing certain 1:45 recommended was allowing certain peptides to be used by compounding 1:48 peptides to be used by compounding 1:48 peptides to be used by compounding pharmacist. So, that's a regulatory 1:51 pharmacist. So, that's a regulatory 1:51 pharmacist. So, that's a regulatory decision about whether a substance can 1:53 decision about whether a substance can 1:53 decision about whether a substance can be potentially compounded or made. It is 1:56 be potentially compounded or made. It is 1:56 be potentially compounded or made. It is not an FDA approval of the peptide as a
What Approval Really Means 1:59 not an FDA approval of the peptide as a 1:59 not an FDA approval of the peptide as a medication and it certainly does not 2:02 medication and it certainly does not 2:02 medication and it certainly does not mean that the compounds have completed 2:04 mean that the compounds have completed 2:04 mean that the compounds have completed rigorous human clinical trials that are 2:06 rigorous human clinical trials that are 2:06 rigorous human clinical trials that are required to really establish for those 2:09 required to really establish for those 2:09 required to really establish for those of us that really want to know before 2:11 of us that really want to know before 2:11 of us that really want to know before you just throw everybody on everything 2:14 you just throw everybody on everything 2:14 you just throw everybody on everything it's they're really required to 2:15 it's they're really required to 2:15 it's they're really required to establish an appropriate dose a proven 2:18 establish an appropriate dose a proven 2:18 establish an appropriate dose a proven benefit remember risk versus reward is 2:21 benefit remember risk versus reward is 2:21 benefit remember risk versus reward is there a proven benefit what's the 2:22 there a proven benefit what's the 2:23 there a proven benefit what's the long-term safety 2:25 long-term safety 2:25 long-term safety and is there medication in interactions 2:28 and is there medication in interactions 2:28 and is there medication in interactions or is there oncological safety that 2:30 or is there oncological safety that 2:30 or is there oncological safety that means what's this going to do with any 2:32 means what's this going to do with any 2:32 means what's this going to do with any cancer cells that are floating around in 2:33 cancer cells that are floating around in 2:33 cancer cells that are floating around in your body 2:35 your body 2:35 your body for several of these peptides 2:37 for several of these peptides 2:37 for several of these peptides a lot of the enthusiasm is still based 2:39 a lot of the enthusiasm is still based 2:39 a lot of the enthusiasm is still based on animal research some laboratory 2:42 on animal research some laboratory 2:42 on animal research some laboratory findings and short-term clinical 2:44 findings and short-term clinical 2:44 findings and short-term clinical experience by some doctors people think 2:45 experience by some doctors people think 2:45 experience by some doctors people think they're seeing things okay but you've 2:48 they're seeing things okay but you've 2:48 they're seeing things okay but you've got to know they have not been approved 2:50 got to know they have not been approved 2:50 got to know they have not been approved and we don't know a lot about them
Safety, Cancer Risk, and Tissue Repair 2:52 and we don't know a lot about them 2:52 and we don't know a lot about them so the distinction is especially 2:54 so the distinction is especially 2:54 so the distinction is especially important when we talk about compounds 2:56 important when we talk about compounds 2:56 important when we talk about compounds that are promoted for tissue repair so 2:59 that are promoted for tissue repair so 2:59 that are promoted for tissue repair so these are the peptides they'll go oh 3:01 these are the peptides they'll go oh 3:01 these are the peptides they'll go oh it's going to repair this tear this 3:03 it's going to repair this tear this 3:03 it's going to repair this tear this problem that you've got if it's if 3:04 problem that you've got if it's if 3:04 problem that you've got if it's if they're promoted for tissue repair new 3:07 they're promoted for tissue repair new 3:07 they're promoted for tissue repair new blood vessel formation something we want 3:10 blood vessel formation something we want 3:10 blood vessel formation something we want to stop in cancer 3:12 to stop in cancer 3:12 to stop in cancer and if they're also saying it's going to 3:14 and if they're also saying it's going to 3:14 and if they're also saying it's going to help growth signaling or mitochondrial 3:16 help growth signaling or mitochondrial 3:17 help growth signaling or mitochondrial stimulation something that theoretically 3:20 stimulation something that theoretically 3:20 stimulation something that theoretically now might assist in healing healthy 3:23 now might assist in healing healthy 3:23 now might assist in healing healthy tissue could behave very differently in 3:26 tissue could behave very differently in 3:26 tissue could behave very differently in somebody with an active cancer 3:29 somebody with an active cancer 3:29 somebody with an active cancer a history of cancer or an undiagnosed 3:31 a history of cancer or an undiagnosed 3:31 a history of cancer or an undiagnosed malignancy
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