Full Transcript Pace of Aging and Epigenetic Results 0:00 But we also can figure out now what we call a pace of aging. 0:03 In other words, we can compare a person's biological aging to a standard calendar year aging, and so we determine if you're in a situation where your epigenetic 0:17 age is accelerating and you are aging biologically faster than your calendar aging This is my results. 0:27 Again, people can't see this, but in 2020, again, I'd been on the peptides for four or five years. 0:34 My pace of aging was 0.92. In other words, i was aging each year 8% slower than my calendar aging. 0:42 in 2021, it improved a little bit and I was, aging 9% lower. 0:45 2022,I was ageing 11% And my last test, the latter part of this last year, 2024, I was aging at 0.79, which is 21% slower than my calendar aging. 1:04 And that's because of the peptides. 1:06 Yeah, exactly. 1:07 I mean, that is notable. 1:12 This one is kind of a before and after. 1:14 Again, like Mark, this is someone else in the program where at their baseline testing, he was ageing 12% faster. 1:22 than his calendar age, and then about two years later, he was aging 10% slower, so a significant turnaround. 1:31 And I won't go into this one, Nathalie, it's a lot of detail that shows basically over a period of a year, huge improvement in this person's... 1:42 Huge wins. 1:43 Huge, big wins here. 1:44 I mean, this is a person who started off at a DNA methylation age nine years older than their chronological, one year, they were now only three years older
Before-and-After Biological Age Improvements 1:58 than their chronological age. 1:59 So is that the right person? 2:00 Am I looking at the thing? 2:02 Yeah, no, you're looking correctly. 2:04 Look at what we call the immune age, that's that secondary test. 2:09 The DNA extrinsic, yeah. 2:11 He had a really good epigenetic immune, age 10 years less than his age but then look a year later, he was now 18 years Wow. 2:22 And his pace of aging went from 12% faster to 10% slower. 2:26 That's a massive delta. 2:29 Yeah, and I would say this is pretty typical. 2:31 I'm going to show you in a moment a slide that has the results for the whole 124, but this, you know, not cherry-picked, 2:36 this pretty much what we saw. 2:41 This is what we call symphony age. 2:42 This particular lab, again, technology advances and so forth. 2:47 So what this lab was doing was they were able to then take 11 of the organs and systems and determine an epigenetic age for each one of those 11 systems, 2:58 and chart them. 2:59 And so the person's current age was 63, but they identified that there were one, two, three, four, five, six of including his lungs, 3:10 musculoskeletal, inflammation, kidney, and hormone age, that were a number of years older than his chronological age. 3:19 And he had a couple of them that where much younger, like his liver was four years younger than current age And so we're able to break it down at this 3:29 point and this is incredibly helpful to me because when I'm putting together the protocol based on telomeres and epigenetics, 3:37 I can target then for this individual I would be using more of the lung peptide Musculoskeletal, inflammation, so forth, 3:46 kidney and so on. 3:46 The metabolic, even like the pancreas, the liver.
System-Specific Epigenetic Age Breakdown 3:50 Yes, all that. 3:51 So it gives me some tools that I can be very specific when I'm creating these protocols. 3:56 Although, just one thing that's really interesting to me is that his liver age is four years younger, but his metabolic age, 4:04 it's six years higher. 4:07 Significantly, yeah. 4:09 Yeah, interesting. 4:11 So, but now what's again, you know, technology advances and so a lab called Generation Lab where I'm actually doing the beta testing now. 4:21 They've, they have a 25 page clinical study peer reviewed and they've been doing this for a little while. 4:30 But I don't take that by itself. 4:32 I've got to do my own testing. 4:35 But they're giving you a pace of aging by system. 4:40 That's pretty dramatic. 4:42 Versus the last test that was giving a global pace in aging, which is also very helpful. 4:48 In terms of targeting your attention on different systems, this would definitely give you some insight. 4:57 It does, and again, it gets incorporated into the protocols that I put together. 5:03 Outside of the peptides, of course, people having this information can do other interventions and be focused elsewhere in terms of what they can, 5:12 in those that are elevated or faster aging. 5:18 I know that your audience can't see all this, but there are 19 different systems and organs that they've been able to determine an epigenetic age of and 5:31 mark those that are aging at a faster speed than those who are younger. 5:36 This person was 44, I think, as I recall. 5:38 I was his chronological age. 5:40 Is this a man? 5:45 Yes, it's a man. 5:46 So then why would they get a reproductive system age on ovaries and uterus? 5:54 Let me take a look and make sure it is a male. 5:56 Just a second. 5:56 No it has to be a woman. 6:00 Because he's a pretty remarkable guy. 6:02 Yeah, he is. 6:04 I just grabbed one of what we call the system age breakdown sheets. 6:09 Actually, we threw this in this morning. 6:11 Well, I'd be curious. 6:18 On the reproductive system, what they would say on a postmenopausal woman versus a premenapausa woman, because post menopause, 6:26 I don't know how meaningful it would be that your system ages older.
Group Study Results and Mortality Risk 6:31 You would think that it'd be just by virtue of the fact that's it's pretty much out of its prime years. 6:39 Yeah, I'm going to connect you up. 6:42 I think you're going find this fascinating. 6:44 But this is just how, as we all know, this how technology works. 6:48 It just gets more specific and broader, more detailed, and more accurate and so forth. 6:54 So we're beta testing this one. 6:56 And if the beta tests turn out the way I they will, then we'll be switching our whole system over to them. 7:07 So the epigenetic study, 124 participants, the average decrease for the whole group in epi-genetic age was 4.67 years. 7:18 Now, that doesn't sound very impressive when we're looking at telomeres, you know, where you get 20, and so forth, but if you're getting a 4,67 we would 7:35 say epigenetic age benefit based on harvest work and so forth, that can turn into a 50 or 60%. I think this one turns into 56% decrease in all cause mortality risk. 7:48 I'm not aware of anything out there that actually can match that. 7:54 Yeah, no, it's pretty dramatic. 7:56 And you know, obviously it depends. 7:58 If the person was showing up 10 years older and now they're only five years old, Obviously, you're going to be better off if you are below the line, 8:08 if your younger than your chronological age, but it still represents a massive decrease in risk and hopefully gives you the impetus to kind of keep moving 8:18 so that you can get below that line. 8:20 Yeah, absolutely. 8:21 And notice, because this was a more recent clinical study, we did the cutoff at two years. 8:29 if a person's on it for four years, what's their result going to be?
Reframing Aging Expectations 8:33 And you're right, the people who are at risk are those who have an older epigenetic age than their chronological. 8:40 And to able to reduce that by more than 50% is just really remarkable. 8:48 So the review of both the telomere and the DNA methylation or the epigenetic age is that in the Telomeres, over a three-year period of time, 8:56 we were able to lengthen people's telomeres by almost 22 years. 9:01 And epogenetically over two-years period time we we're able reduce their epigene age significantly, but more importantly, 9:10 reduce the all-cause mortality risk by 56%. It's pretty sweet. 9:18 So this slide just shows the kind of what we call current aging expectations. 9:27 This is how people view aging. 9:29 They start off as an infinite young person, middle-aged, and then they start declining and they're frail and so forth. 9:36 Cavinsen and I don't believe that this is everyone's fate. 9:40 We think that with the bioregulators, and also when I say the bio regulators, you still have to do a lot of other things to be healthy, 9:46 as you and have talked about. 9:47 Thank you. 9:47 You've got to clean up the diet and so forth. 9:51 But this how Professor Cavinson and see things where a person hits middle age, they start getting older, They clean up their life with bioregulators and 10:01 diet and all the other technical things that are becoming available and they end up having extended life by 10 or 15 or 20 more years.
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