REAL Science Behind NAD+

🔹 About This Episode:

In this episode of the Longevity Podcast, I sit down with biomedical engineer and longevity entrepreneur Courtney Van Bussum to unpack the real science behind NAD+ metabolism and why the current obsession with boosting NAD+ through supplements, infusions, and precursors may be missing a critical piece of the puzzle. We explore the complex biology behind NAD+, NADH balance, the salvage pathway, and the role of enzymes like CD38 and NNMT in regulating cellular energy, inflammation, and aging. Courtney explains why simply increasing NAD+ levels isn’t always beneficial—and how pushing the system too hard can actually disrupt cellular balance.

We also dive into the hidden role of methylation in NAD metabolism, why many people may not respond well to common precursors like NMN and NR, and the emerging science behind molecules such as 1-MNA that may support microvascular health, nitric oxide production, mitochondrial function, and metabolic resilience. We discuss practical strategies for protecting your NAD system through sleep, circadian rhythm, exercise, ketones, and metabolic health, as well as the limitations of current NAD testing and biomarkers. If you want to intelligently optimize energy, immunity, and longevity—without falling for the hype—this episode will change the way you think about NAD+ supplementation.

If you want to try Endotelio 1-MNA and save 10% click here and code NAT10 will be entered for you at checkout.

🔹 What you will learn:

→ Why simply boosting NAD+ with NMN, NR, or IV infusions may not work—and how it can actually disrupt your NAD⁺/NADH balance
→ The hidden role of methylation, CD38, and NNMT enzymes in NAD metabolism—and why these factors determine whether supplementation helps or harms
→ How emerging molecules like 1-MNA, along with sleep, circadian rhythm, exercise, and ketones, can support cellular energy, mitochondrial health, and longevity

🔹 What We Discuss:

Welcome and introduction to Longevity Podcast … 00:00:00
Challenging beliefs about aging and cellular health … 00:12:00
Deep dive into NAD+ biochemistry and cellular function … 00:13:08
NAD+/NADH balance: Why both matter … 00:15:24
Why NAD+ declines: Not just aging, but increased degradation … 00:18:26
The role of CD38 and NMNT enzymes in NAD metabolism … 00:20:14
Controversy and confusion: NAD+ precursors (NR, NMN) and IVs … 00:22:28
Methylation’s hidden importance in NAD supplementation … 00:30:55
Supplementing 1-MNA: Understanding dosages and applications … 00:50:54
Assessing NAD+ status: Biomarkers and limitations of testing … 00:53:01
Lifestyle ROI: Sleep, exercise, and circadian rhythm for NAD preservation … 00:57:14
Ketones: Beyond performance, supporting cellular energy and longevity … 01:06:03
Future of NAD science: Anticipating new insights and risks … 01:11:45
Confidence and humility: Advice for navigating the longevity field … 01:18:52

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🔹 Learn More From Courtney Van Bussum below:

• Website: https://ohphealth.com/products/endoteliol-1mna?sca_ref=9986562.lm23X9vLd2&sca_source=NatNiddam
• Instagram: https://www.instagram.com/ohphealth/?hl=en

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🔹 Thank You To Our Sponsors For Making This Episode Possible:

• Qualia Creatine+ by Qualia Life – A clinically formulated blend of two highly bioavailable forms of creatine plus magnesium and electrolytes to support lean muscle, cellular energy, and brain health—especially for women over 40 who naturally produce less with age. Go to http://qualialife.com/nathalie and use code NATHALIE to save up to 50%, plus an additional 15% off.

• Complete Liver Complex by LVLUP Health – supports your liver’s natural detox pathways so your body can reset after the holidays without suffering. Go to https://lvluphealth.com/?ref=nat and use code NAT for 20% off.

• Gut Essentials Bundle by Just Thrive Health – This powerhouse duo pairs the only probiotic clinically proven to arrive 100% alive in your gut with science-backed Digestive Bitters to reduce bloat, curb cravings, and support better energy fast. Take the Just Thrive Feel Better Challenge and save 20% at http://justthrivehealth.com/NAT20 with code NAT20.

🔹 Find more from Nathalie:

• YouTube: / @nathalieniddam9630
• Join Nat’s Membership Community: https://www.natniddam.com/the-longevity-community
• Sign up for Nats Newsletter: https://landing.mailerlite.com/webfor…
• Instagram: / nathalieniddam
• Website: NatNiddam.com
• Facebook Group: / biohackingsuperhumanperformance

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