Science of Ketosis: Regain Your Metabolic Health & Age Backwards

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The ketogenic diet has become a household term, often associated with rapid weight loss and an effective means of shedding stubborn fat. However, as my guest on this episode of The Empowering Neurologist, Dr. Dominic D’Agostino, will explain, there is so much more to the ketogenic lifestyle than simply dropping a few pounds. We’re diving deep into the science of metabolism, insulin sensitivity, and how our lifestyle choices impact long-term health, particularly brain health.

Dr. D’Agostino is a leading researcher in the field of ketogenic therapy and metabolic health. His work has shed light on how nutritional ketosis can be used not only for weight management but also for optimizing brain function, enhancing endurance, and even supporting neurological conditions. His expertise brings a fresh perspective on why maintaining metabolic flexibility is one of the most important things we can do for our overall well-being.

While many people adopt a ketogenic diet for its well-documented benefits in weight management, its effects on metabolism reach far beyond simple fat burning. Nutritional ketosis helps the body transition from relying primarily on carbohydrates for energy to efficiently burning fat and producing ketones, an alternative fuel source for the brain and muscles.

As Dr. D’Agostino will discuss, one of the most crucial aspects of metabolic health is insulin sensitivity. When insulin function is compromised, the body struggles to regulate blood sugar levels, leading to increased risks of obesity, type 2 diabetes, and even cognitive decline. By keeping insulin sensitivity in check through dietary choices, fasting, and exercise, we can enhance our metabolic health and lower the risk of chronic disease.
The brain is an energy-intensive organ, and its function is directly influenced by our metabolic state. Research has shown that ketones provide a more efficient and neuroprotective fuel source for the brain compared to glucose. This is particularly relevant for conditions such as Alzheimer’s disease, epilepsy, and even traumatic brain injury.

By making intentional choices about what we eat, how we move, and how we recover, we can take control of our metabolic health and improve our longevity.

This episode of The Empowering Neurologist is packed with cutting-edge insights from one of the leading experts in ketogenic research. Whether you’re already following a ketogenic lifestyle or simply curious about how metabolic health impacts brain function, you won’t want to miss this conversation with Dr. Dominic D’Agostino.

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TIMESTAMPS
00:00 Introduction
02:21 How Dr. D’Agostino Went From Seizure Research To Nutrition Science
03:31 From Drug Failures To The Medical Power Of Ketosis
05:15 What Ketones Really Are And Why They’re A Metabolic Game-Changer
09:37 Why Ketogenic Therapy Is Now In 400+ Clinical Trials Worldwide
12:21 GLP-1 Drugs, Weight Loss, And Keto: What They Do To Your Metabolism
15:10 Inside A Ketogenic Body: Fat Burning, Fuel Switching, And More
17:25 How Lowering Insulin Turns On Fat Burning And Ketone Production
20:03 Why Ketones Keep The Brain Stable And Cravings Under Control
23:54 The Right Amount Of Protein For Muscle, Aging, And Staying In Ketosis
27:03 Do You Actually Need Fiber? The Carnivore Diet And Gut Health
30:00 How Ketosis Reduces Inflammation And Repairs The Gut Barrier
34:31 Genomics of Ketonics: Beta-Hydroxybutyrate’s Epigenetic Power
45:38 Allulose: The Sweetener That Lowers Blood Sugar And Boosts GLP-1
52:03 Why MCT Oil Might Be The Most Underrated Keto Hack Available
54:30 Conclusion

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Dominic D’Agostino, Ph.D., is a tenured Associate Professor at the University of South Florida (USF) Morsani College of Medicine in the Department of Molecular Pharmacology and Physiology. He teaches medical neuroscience, medical physiology, nutrition and neuropharmacology. He is also a Senior Visiting Research Scientist at the Institute for Human and Machine Cognition (IHMC) to assist with their efforts towards optimizing the safety, health and resilience of the warfighter and astronaut. His primary research focuses on developing and testing nutritional and metabolic-based therapies for a variety of disease states and advancing the use of metabolic-based therapies into human clinical applications.

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