Full Transcript Welcome and neuroinflammation overview 0:00 Hi everyone. 0:00 Welcome to the Healing Lyme Summit 3.0. 0:05 I am your host, Doctor Myriah Hinchey, and I'm here 0:09 with my co-host, Doctor Richard Horowitz. 0:12 And today we're going to talk about neuroinflammation and the link between 0:18 chronic Lyme disease and Alzheimer's, as well as neuro inflammation in general. 0:24 So thank you so much for joining me, Doctor Horowitz. 0:27 My pleasure. 0:27 Good to see you as always. 0:29 Absolutely. 0:30 So chronic Lyme disease patients often have inflammation 0:34 as the underlying cause of most of their symptoms. 0:38 Let's talk a bit about how that inflammation affects 0:41 symptoms of cognition, including brain fog. 0:46 Yeah. 0:46 So when people complain of symptoms of I'm tired, 0:50 I have muscle aches, I have joint aches, 0:52 I have nerve pain, tingling, numbness, burning, stabbing sensations. 0:56 I can fall asleep. 0:57 I keep waking up in the middle of the night, my can't remember words. 1:00 I'm walking into rooms and forgetting why I walked in. 1:03 They have word finding problems, number of problems. 1:05 All of this is basically from inflammation. 1:08 So Lyme disease and in our case and I think it's your practice too. 1:12 It's not just Lyme that's driving the inflammation. 1:14 I mean in most of our cases Bartonella is just right behind that. 1:17 Probably 80 to 90% of the cases. 1:19 But B.C. 1:20 is not too far behind that, probably at least 70 or 80%. 1:23 And then, you know, we're also seeing reactivated viruses like some of the long 1:27 Covid patients have had reactivated Epstein-Barr herpes virus six. 1:32 But we're also seeing inflammation coming from all toxins from heavy metals. 1:35 So inflammation is not just coming from Lyme. 1:38 But Lyme is one of the major factors that's driving the inflammation. 1:41 And the reason 1:43 I wanted to do this summit with you, and specifically talk about this today, 1:47 is because Alzheimer's disease is a big problem, 1:50 you know, not only just in the United States, 1:52 where they're expecting the numbers that the US numbers from years ago 1:56 is that there was 46.5 million people with preclinical dementia, 2:01 46.5 million people with preclinical dementia. 2:05 And when you look at the studies on Alzheimer's, 2:07 the rates doubled roughly in the last 12 years. 2:11 They're expecting like 55 million people in the world 2:14 based by 2060, that are beginning to be demented. 2:17 So it's the fifth leading cause of death, and we talk about it all the time. 2:21 But I think 2:22 when we talk about Lyme disease, nobody's really ever put together the fact 2:25 that it is actually one of the causes of why someone may get Alzheimer's. 2:29 And I'll give you a perfect example. 2:31 We're going to talk about a couple of cases today, including a case study 2:34 that I submitted to the Journal of Alzheimer's Disease Case studies. 2:37 One of my patients in Massachusetts was diagnosed with Alzheimer's disease, 2:42 and the neurologist who saw him had a he had a positive 2:45 F18 Pet scan showed amyloid production. 2:48 The neurologist never checked him for Lyme or Bartonella. 2:52 The neurologist never checked him for mold. 2:54 In other words, he never checked him 2:56 for any of the 16 absence factors and started him on lecanemab, 3:00 which is this monoclonal antibody that, you know, pulls out amyloid. 3:04 But the problem is 15 to 20% of the cases can get brain bleeds and brain shrinkage. 3:09 And it doesn't stop the process from going forward. 3:12 So I said to the patient and the family, let's do a Lyme immuno blot. 3:16 It lit up like a Christmas tree. 3:18 His Bartonella immuno blot was positive. 3:20 His Bartonella fish was positive. 3:22 And we just got back all toxins that are off the wall elevated. 3:26 So he's got multiple factors driving inflammation. 3:29 So if you're a line patient and you have chronic Lyme disease, 3:33 post-treatment Lyme disease syndrome, and you're complaining of symptoms 3:36 fatigue, joint pain, muscle pain, nerve pain, sleep disorders, memory, 3:40 just know that inflammation is really one of the major reasons why you have it. 3:45 And the reason I keep talking always in the last 3:47 this point couple of decades about the SIDs model is 3:51 the inflammation is usually not just coming from Lyme disease, 3:54 but one of the most interesting things we're going to discuss today
Lyme, inflammation, and Alzheimer's connection 3:57 is just a couple of years back that even Ciampi and her group discovered, 4:01 and this is autopsy cases, not live cases, that amyloid 4:06 P2 phosphorylated tau and biofilms were found for Lyme disease 4:12 in the brains of people, autopsy patients with Alzheimer's and Parkinson's. 4:16 So we have proof that Lyme disease may be one of the underlying causes. 4:21 And we'll talk in a second about how frequent I think that is. 4:24 But the fact is, is that up until a couple of years ago, 4:28 we didn't have easy biomarkers in the last two years. 4:31 I started going to quest and LabCorp and looking at some of these biomarkers 4:35 that are now widely available. 4:37 And I've got I've got the codes for everybody today. 4:39 So you can listen to this talk 4:41 and you can kind of write down the codes and speak to your doctor about it. 4:44 I'll talk to an end just in a second about it. 4:46 But instead of doing spinal taps, very invasive. 4:49 We're going for F-18, Pep scans. 4:51 You now have the ability to go to quest or LabCorp. 4:55 And I specifically like Quest Labs a bit better based on the lab 4:57 quest testing I've gotten. 4:59 But you can check markers like ApoE e to see what does your genetic risk 5:04 of Alzheimer's if it's for for you have a higher genetic risk. 5:07 You can check a marker called P-Town 217. 5:11 This marker is highly associated with beta amyloid in the brain, 5:15 and has been shown that if you have an elevated P2 17, 5:18 the odds of becoming demented 15 to 20 years later is quite high. 5:23 And the case I'm going to talk to you about today, that was that was her case. 5:27 This is a 60 year old woman came to me for 15 years, mild Lyme symptoms. 5:33 You know, she had an M rash, was treated, but still had some joint pain. 5:38 Rheumatoid factors were elevated. 5:40 And she had she told me her condition she thought was fine. 5:43 So over the years we were using Byron White IRBs. 5:47 We were using Beyond Balance herbs. 5:49 We were using Cowden herbs. 5:50 We using all kinds of natural things 5:52 because she wasn't sick enough to do antibiotics. 5:55 And there came a point when these biomarkers became available from quest. 5:59 I said to her, you know, I started checking my line patients, 6:02 and I noticed that over 50% of the patients were starting 6:05 to test positive for these biomarkers of inflammation. 6:10 And I said, would you be willing to do it? 6:11 She said, sure. 6:13 So she did the test and her for 2017 was elevated above range. 6:18 Beta amyloid was normal, but because of the P 6:21 and because she had a family history of Alzheimer's, although her marker, 6:24 she was ApoE e3 three and her grandmother had Alzheimer's, 6:27 she decided to do daptone. 6:29 And lo and behold, we saw a lowering down of the tau. 6:33 217 three months later. 6:35 Now for those of you listening to this, this may not mean a lot to you, 6:39 but this is the first case study that has ever been published 6:43 in the medical literature 6:44 that we can go in and we can reverse these type of Alzheimer's 6:47 biomarkers and hopefully prevent cognitive decline later in life. 6:50 Now again, it's going to need to be proven in a multicenter, double 6:54 blind, placebo controlled trial. 6:56 But we're talking that, you know, about a study 6:59 now that has really, really big implications for people. 7:02 So I want you to make sure that you and I had a chance 7:04 to kind of go into this in detail and share it with people. 7:07 Yeah, I know this is great. 7:09 So you mentioned two of the markers. 7:11 Since we're already talking about it, why don't you be complete with that list 7:15 that our listeners can actually ask their doctors 7:19 to test them for at quest or LabCorp? 7:23 Yeah. 7:23 So the the other marker so you can get a beta amyloid ratio. 7:27 In fact, I'll give you I wrote down the codes here from quest. 7:30 The beta amyloid ratio code, 4240 is 11786 7:35 beta amyloid 4240, ratio number 11786P tau 7:41 217 that we were describing the number. 7:44 The code from quest is number 13825. 7:48 Again pitch out 217. 7:50 Number 13825 P-Town 181. 7:54 The number is number 13690. 7:57 Again. 7:58 Number 13690 neuro filament light. 8:02 Another marker of neuroinflammation. 8:04 That quest code is number 13979. 8:07 It's called NFL Neural Filament light. 8:09 Number 13979. 8:11 And if you want to check your genetic markers for eight bogey it's number 12563. 8:16 So these are the markers that we started doing on our patients. 8:20 And again I started doing this towards the end of my one on one clinical career. 8:24 Right. I've now moved into consulting model. 8:26 So unfortunately 8:28 we did not have the chance to do before and after markers in these patients 8:32 because most of my patients had already done adoption combination therapy. 8:36 So this woman had put off doing DAP seven for 15 years. 8:40 The only reason she basically did it was because 8:43 her rheumatoid factor was still elevated with some joint pain. 8:46 The tau 217 was elevated and I said, listen, 8:49 I don't have any evidence that we are going to reverse this, 8:53 but I will tell you, based on what I've read in the literature, 8:56 that they know with Alzheimer's disease and autopsy studies, 8:59 they found Lyme, they found biofilms, they found peto, they found beta amyloid. 9:04 I said, and we know that that zone has great penetration into the brain. 9:08 The number one effect from DAP shown statistically significant 9:11 is improving cognition. 9:13 I said, you're one of the few patients who has never done it. 9:16 Would you be willing to. 9:17 She did it. And again, we checked the markers. 9:19 Three months later, her rheumatoid factor reversed back down to normal. 9:23 Joint pain got better and interesting. 9:25 You know, we didn't. 9:26 Again, we didn't know she had cognitive issues 9:28 because she thought her meditation practice was contributing to her 9:32 her good cognition. 9:33 She said to me afterwards, and I put this in the paper that we reported 9:37 that she found that she was definitely clearer, like the word recall was better. 9:41 So what she was assuming was taking good care of herself. 9:45 I'm meditating, I'm exercising, I'm getting enough sleep. 9:47 I was like, no, I absolutely see a difference. 9:51 Really fascinating. 9:52 Yeah. 9:52 So those so those are the markers that you want to speak to your doctor about. 9:55 And I want to be clear with people don't freak out 9:59 if you do these tests and they come back positive. 10:02 It's not like we're going to talk today during this talk with Maria. 10:05 We're going to talk about what you actually can do for this. 10:07 Because Alzheimer's is not a death sentence. 10:10 I'm publishing in the literature. 10:12 This is also in the case study that we're reporting 10:14 to the Journal of Alzheimer's Case Studies, that all 16 factors 10:19 that we've been talking about for chronic Lyme now 10:22 in my bestselling books, why can't I get better? 10:24 How can I get better? 10:25 We'd be discussing it also in my new book from Simon 10:28 and Schuster, which will be out later this year called Ending Chronic Illness. 10:31 I have a whole section in the book on Alzheimer's 10:34 and how all 16 factors on the M6 model are associated. 10:38 So if these markers come back positive,
Biomarkers for Alzheimer's risk and testing codes 10:40 you're not going to all of a sudden just worry, oh my god, 10:43 I have to go on Aricept or Namenda or some of these drugs that are out there. 10:47 What you need to do is go back and say, where is the inflammation coming from? 10:52 Check your genetic markers for eight bogey, but check for infections. 10:56 Do I have chlamydia pneumonia a chlamydia pneumonia is also 11:00 an intracellular infection that's been associated with Alzheimer's. 11:03 Just as Borrelia Bergdorf right. 11:05 And even then to call a aspire keeps from the mouth 11:08 each pylori cue fever Cox yellow Brunetti. 11:11 It's one of the tick borne infections. 11:13 It's published in the Medical literature that it is associated 11:16 with Alzheimer's dementia. 11:17 But so is herpes virus one, herpes virus six, herpes virus seven CMV. 11:23 So there's viruses that are associated. 11:25 And there are again antiviral treatments that may be able to help in that case. 11:29 The point being, if you do get back these markers, 11:33 you don't just go to a neurologist and say, put me on namenda 11:37 put me on an acetylcholinesterase inhibitor, 11:39 because that does not change the course of Alzheimer's. 11:42 It may improve your memory, but it's not going to change the clinical course. 11:45 You actually need to find out where the inflammation is coming from. 11:49 So I think that's the most important point, 11:51 because in the patients that I checked before, we finished one on one practice 11:55 and I've got ten of them here 11:56 briefly, I'll talk to you about some time during the talk today. 11:59 Three of those patients who finished apps on the PTL levels were fine, 12:04 and the beta amyloid ratios were completely normal. 12:07 But in seven of them who never finished capstone, 12:10 they did have these elevated markers, whether it was beta amyloid, 12:14 PTL 181, PTL 217, or neuro filament light. 12:18 I'll go into some of those cases later. 12:20 But but it's important to kind of think about this, because 12:24 when you go to your doctor now for treatment for Lyme, 12:26 there's so many treatments out there. 12:28 What I'm suggesting is we now need to kind of not necessarily 12:32 raise the bar, but add this piece of information, 12:35 just like you would check for co-infections, 12:37 just like you would check for mold and heavy metals. 12:40 And many times we check autoimmune markers like 12:42 antinuclear antibody, rheumatoid factors, which this woman had. 12:46 She was not CCP positive. 12:48 She did not have the autoimmune marker for rheumatoid arthritis. 12:51 It was not an autoimmune. 12:52 It was an autoimmune problem she had from the Lyme, 12:55 which reversed when she finished the absent. 12:58 So again, I think these markers now need to be incorporated 13:02 because the Alzheimer's rates we're talking about, 13:05 they're going up significantly as time goes on. 13:07 It's the fifth leading cause of death in America going forward. 13:11 And I think now that we know that Lyme Borrelia burgdorferi can be associated, 13:15 and we know that Daptone has great penetration into the brain, 13:19 I need docs out there to start looking at this. 13:21 Obviously, the randomized, multicenter study will help us to determine 13:25 right with longer term follow up to whether what we found actually 13:28 is going to hold up right in the scientific literature. 13:31 Right? 13:32 So I think, you know, the take home point from all of 13:35 that is that there are markers and we can have these markers tested, 13:39 and they can actually give us clues before the full 13:43 on, you know, disease process has taken over. 13:48 So we can look at these, we can use these to screen. 13:51 And if we see that they're elevated, we can use them as warning signs. 13:55 But also a guide as to how to how to help that patient. 13:59 So if you do have these markers elevated you should be looking for all of the, 14:05 you know, Berlioz, all of the co-infections, 14:09 all of the viruses that often will overrun the body 14:12 when the immune system has been skewed from one of these vector borne diseases 14:17 and obviously we have to get to that root cause we have to look 14:21 at eliminating these infections, but also we have to deal 14:25 with that neuroinflammation that is driving the process. 14:29 Because I think the thing that we've left out so far in this conversation 14:33 is that the development of beta amyloid plaque and RPE tau 14:38 is actually the body's innate defense 14:41 to trying to deal with these organisms 14:44 presence in the brain, because they shouldn't be there. 14:48 But when they can get there through a leaky blood brain barrier 14:54 because of the neuroinflammation, it turns into this vicious cycle. 14:59 So while we're trying to identify and eliminate these underlying causes, 15:04 there's a whole host of things that we can do to deal with the neuroinflammation 15:09 and actually start to, you know, pull out the beta amyloid plaque, 15:13 like using curcumin, using Chinese skullcap, using green tea. 15:19 And then, amazingly, these same agents actually help to decrease tau as well. 15:25 So as Doctor Horowitz said, don't freak out 15:29 if you come back with these markers, it's not a death sentence. 15:33 Use them to guide you and work 15:36 with your practitioners to really get to the root causes. 15:40 The root infections that are driving this actual like normal process in the body, 15:46 that your body is literally trying to protect you from these organisms. 15:51 Wouldn't you agree, Doctor Horowitz? 15:52 No, absolutely. 15:53 And let me just read this is directly from the article that that I submitted. 15:57 Let me just show you the 16 factors. 15:59 You have a sense of what this is. 16:00 So we talked about Clemente pneumonia. 16:03 We talked about Lyme disease driving amyloid production in the brain. 16:07 Each pylori Cox yellow Brunetti two fever herpes viruses. 16:10 So toxoplasmosis, right. 16:12 One third of the world's population has been exposed to talk. 16:14 So it's not always active. 16:16 But if it is active, it's it's been shown to be one of those causes 16:20 fungal infections, Candida infections Malaysia this other fungal species 16:25 that have been associated, 16:26 they actually find these fungal species in the brains of Alzheimer's patients 16:29 on autopsies, environmental toxins, air pollution like fine particulate matter. 16:34 So heavy metals, pesticides have been associated with amyloid 16:37 production and tau microbiome abnormalities. 16:40 Decreased diversity and abundance of your beneficial bacteria. 16:44 So you could do a GI map. You can do a CD assay. 16:46 You can look at the microbiome 16:48 to see whether you've got the right type of short chain fatty acid bacteria 16:52 that lower inflammation, intestinal hyper permeability with leaky gut. 16:56 You were mentioning the the leaky blood brain barrier. 16:58 This is also a problem with leaky gut. 17:00 With or without mast cell activation. 17:02 Vitamin mineral deficiencies, B12 deficiency, B6, 17:05 B9, folic acid, vitamin D, vitamin E 17:09 all published in the medical literature associated with Alzheimer's dementia. 17:13 Not getting to sleep, which is a problem with Lyme disease, 17:15 of course, where you don't fall asleep or wake up frequently. 17:18 That will drive some of this phosphorylated tau in the brain, 17:22 and beta amyloid and finally, the ten downstream effects on the M6 model 17:27 that have been associated is mitochondrial dysfunction, 17:30 hormone and immune dysregulation, autoimmunity. 17:34 Liver disease like nonalcoholic steatohepatitis, 17:37 fatty liver, which is affecting a third of the world's population. 17:41 It causes insulin resistance, which has been associated also 17:44 with problems with dementia, neurological psychological trauma, and dysfunction. 17:49 Autonomic dysfunction. 17:50 As we see in many of our patients deconditioning and pain syndromes. 17:54 So every one of the 16.6 model factors have been associated with Alzheimer's. 18:00 So if you do again, these markers, you go to your doctor 18:03 and you go, I have to be checked for all of these things. 18:06 And if it turns out that 18:07 the Lyme is active and you've not used a persistent biofilm regimen, 18:11 what I am suggesting is that your doctor wants to do it before 18:14 and after with these markers, and then we can accumulate the data.
Case study: reversing inflammatory markers with treatment 18:18 And again, it can be published in the literature. 18:20 So where can our listeners find that complete list. 18:25 Well, 18:26 hopefully this article by the time the our Lyme summit is out in May, 18:30 the article should normally be published in the Journal of Alzheimer Disease 18:33 Case Studies, but also the Alzheimer section. 18:36 All of these are found in my new book and in Chronic Illness. 18:39 The website is ending Chronic illness.com and the book will be out later this year. 18:43 But interestingly enough, what we found with the 16 point 18:47 map is it's not only affecting chronic Lyme patients with PTSD. 18:52 We published two years ago that it's associated with long Covid. 18:56 All 16 factors are seen in Long-covid. 18:59 And before 18:59 I got the contract for Simon and Schuster to do this book, we knew Alzheimer's. 19:03 That was the one that I pitched the book. 19:06 But since then, we discovered that the 16 point 19:08 M6 model is associated with ADHD, with autism spectrum disorder, 19:14 with allergies and asthma, with the three B's Borrelia, Bartonella, 19:17 but Busia with disease, cancer, cardiovascular disease, 19:22 chronic fatigue syndrome, myalgic encephalomyelitis, fibromyalgia, digestive 19:27 disorders like Crohn's, ulcerative colitis, functional medicine disorders, 19:31 Autoimmune disorders like rheumatoid arthritis and M.S.. 19:35 Hormonal dysregulation. 19:37 In other words, all of the things that we find in our Lyme patients 19:40 that are causing chronic illness in this country and across the world. 19:43 When I did a deep dive in the medical literature, 19:46 and I have approximately 2000 references backing this up, in fact there's so many 19:50 they can't even put them in the book. 19:51 They're putting it on my website. 19:52 All of these different diseases. 19:55 Right? 19:55 Including long Covid, including hormonal dysregulation. 19:58 All 16 factors are showing up in all of these diseases, which is amazing. 20:02 It means we now have the ability to have a paradigm shift. 20:06 So if you are a line patient who has A.D.D. 20:09 or you're a mother with Lyme disease, 20:11 you may have passed on the line to your child. 20:13 And we've seen this happen with autistic kids. 20:15 I have some of the practitioners out there that have used low dose nap zone 20:19 and seen that sometimes the brains do work up in the in these children. 20:22 The point being, we now have a new model for chronic illness. 20:26 So in this case we're talking about Alzheimer's. 20:28 But all of the 16 factors and exactly how they relate, 20:32 they will be in the paper that will be published 20:34 in the Journal of Alzheimer's Case Studies and also an end in chronic illness. 20:39 That's amazing. 20:40 That's such a you know, as I told you, when I first laid eyes on your book, 20:44 like this book is needs to be a desk top reference for physicians. 20:49 And, you know, it's funny, like, as a naturopathic doctor, I mean, your 20:53 the way that you're approaching this, this is kind of like the way 20:56 that I was taught, taught to approach really 21:00 any illness, you know, when you're, when you're working somebody up. 21:04 So, you know, it's so important to look at all of the pieces of the puzzle 21:09 and do personalized, individualized medicine, 21:12 like with that patient sitting right in front of you. 21:15 So I'm so glad that you have this as a reference for our. 21:18 Yeah. 21:18 I mean, 21:19 when I spoken to natural paths in the past, 21:21 it seems like I'm more in line with the naturopathic population than I. 21:24 Sometimes you are even with my own and but it's in what's 21:27 so strange about it is, you know, that the health care costs in this country, 21:30 18% of our GDP is is health care costs, 21:34 and 86% of our health care costs are chronic disease. 21:38 70% of our health care costs are relate to deaths in this country. 21:42 And we have no model for chronic illness. Right. 21:44 So the the levels of chronic illness keep going up. 21:47 1 in 2 Americans has one chronic disease. 21:50 Two, I think it's about 25% of Americans have two or more. 21:54 So we're dealing with a chronic disease epidemic in this country and in the world. 21:59 And there's no like model to be addressing it. 22:01 What we've done in medicine, unfortunately, is we name the disease 22:05 and we throw drugs at it. 22:06 And I have nothing against the pharmaceutical industry 22:09 that some combination 22:10 therapy uses a lot of these drugs, but that's not the root cause medicine. 22:14 Root cause medicine means you 22:16 name the disease and get to the underlying 16 factors. 22:20 So then maybe you still will use some of these medicines. 22:23 But there's also when I have stories informing every chapter in this book, 22:26 these are personal patients. 22:28 Over 41 years of seeing 13,000 of these chronically ill patients, 22:32 where we've reversed the ad in these patients and the autism spectrum 22:35 disorder got better and the allergies got better, and the migraines got better, 22:39 these are all just informed by you didn't get through all the 16 factors. 22:43 So instead of just here's your migraine medicine. Right. 22:46 Oh you you're missing magnesium. 22:48 You needed you had mitochondrial dysfunction. 22:50 You needed CoQ10. 22:51 Your blood sugar swings with mast cell disorder was driving your migraines. 22:55 We don't think you think this way. 22:57 And I think this way, but it's just not been taught, I think, in medical school. 23:01 So you're right. 23:02 I mean, I, 23:03 I hope this book gets into the hands of doctors 23:05 and patients is kind of like the next Burke manual of 23:07 when you have something wrong with you, look up the 16 root causes. 23:10 Because in the book I described not just the pharmaceuticals, 23:14 but all of the pathways, all the inflammatory pathways. 23:17 By the way, what's interesting, I didn't mention this. 23:19 I found when I was doing the research that even though there are 16 factors 23:24 underlying all these chronic diseases, including Alzheimer's, 23:27 there are 16 inflammatory pathways 23:30 underlying the 16 M6 factors. 23:33 So a lot of times you and I have talked about NF kappa. 23:36 It's one of these inflammatory pathways. 23:38 Turns on TNF alpha, interleukin one interleukin six IL 17 drives inflammation. 23:44 The Nrf2 pathway that lowers inflammation. 23:47 And in Alzheimer's, this third pathway is called Nlrp3 inflammasome. 23:52 So the beta amyloid and phosphorylated tau that's clogging up your neurons 23:57 when you can't think is coming from inflammation in the brain 24:00 from microglia, these small cells in the brain 24:03 that turn on a third inflammatory pathway called the NLRB inflammasome. 24:08 And you and I have discussed in another episode here 24:11 how we shut down the NLRB three inflammasome, right. 24:14 Using low dose naltrexone, low dose melatonin, some of the IRBs 24:17 you just discussed. 24:18 But also that zone is in neuroinflammation inhibitor. 24:23 So in a study that was done about four years ago in Korea with over 24:27 3000 leprosy patients, they followed them for 15 years. 24:31 The leprosy patients who took rifampin and DAP zona, 24:34 which is part of the adaption protocol, that's how I got it. 24:37 The rates of Alzheimer's disease were like six times less. 24:40 If they took taps on the leprosy patients 24:44 that didn't take that zone, the Alzheimer's rates were off the wall. 24:47 Now they were suspecting that the reason the Alzheimer's was stopped by DAP zone, 24:52 right, is because it was acting as an LRP three inflammasome inhibitor. 24:57 It was stopping the inflammation in the brain, 24:59 driving beta amyloid, driving phosphorylated tau. 25:03 Now, we don't know whether those Korean patients had Lyme disease or not. 25:06 We don't even know how many of the 16 eminence factors they had. 25:10 But interestingly enough, you hear about all these Alzheimer's drugs. 25:13 You never hear about that. 25:15 So and I had a patient in the Midwest, she's 80 years old. 25:19 She's one of the ten patients I was going to discuss today. 25:22 She took 25mg of DAP zone, which for me 25:25 is almost like homeopathic DAP shown like literally no side effects. 25:28 You don't notice it. 25:30 And she told me after a year, year 25:31 and a half, she said, my memory is so much better. 25:34 But we recently tested her. 25:36 She came to see me in New York 25:38 right before I finished clinical practice, and we tested her. 25:41 And one of her Alzheimer's markers, or PDL 181, was elevated. 25:45 And I said to her, listen, you clearly noticed your memory was better 25:49 from even the low dose zone. 25:51 And she's not even 25:51 noticing a lot of memory issues, but couple of word finding problems, 25:55 which you might say at 80 years old is normal. 25:57 But can we do better? 25:59 I said to her, listen, you really need to consider doing the higher dose zone. 26:02 But then we tested her and we're finding mold. 26:04 And so the point being, you don't just accept the diagnosis, right. 26:09 You don't just accept your cognitive issues. 26:11 Get to the 16.6 model to find out what's underlying the inflammation. 26:16 And then we may have other options. 26:18 For some people it may be some combination therapy. 26:21 This is again one case study, 26:23 but the first one ever published 26:25 in the medical literature that we can reverse p tau 2017, 26:29 which is the most important biomarker that people go on to dementia later on. 26:33 So it's it's really exciting information for the line community 26:37 that this is something that not just makes you feel better with fatigue 26:41 and joint pain, but might and I say might, 26:44 might be able to prevent cognitive issues and dementia later on in life. 26:49 Yeah. 26:49 And I mean, that's just I think even knowing 26:52 these markers, looking at them more as a screen. 26:55 Right, so that you can prevent because earlier you had said 26:59 that these markers could predict like severe dementia or Alzheimer's. 27:03 Wasn't it like over a decade later? 27:06 Yeah. 27:06 It's like even 15 to 20 years later, the PTO 2017, it's 15 to 20 years 27:11 down the line. So if you're someone who finds it, 27:13 this is not an immediate like death sentence. 27:15 You're going to develop Alzheimer's, but it does mean 27:18 that you have something going on in your brain, right? 27:20 You've got inflammation going on 27:22 and now you got to figure out where the inflammation is coming from. 27:25 So again, the standard medical model, which I don't use 27:28 or you don't use where you name the disease and throw drugs at it, 27:31 it's about getting to the underlying inflammation. Right. 27:34 Where's what are the 16 point m sense factors. 27:37 And you know what's interesting is Judith McCloskey. 27:39 Years ago, she's published 4 to 5 articles that there's 27:42 absolutely no doubt that Lyme has an association with Borrelia. 27:45 When they did autopsy studies, they found that line was ten times 27:49 more frequent, right? 27:51 When they were looking at these autopsy cases of these Alzheimer's. 27:53 So we know that there's an association, she called it by Cox and Hill's 27:58 criteria that it's indisputable there's a statistical relationship. 28:02 It is one of the causes. 28:04 And they found that 28:05 in the Alzheimer's cases they looked at, it was ten times more frequent. 28:09 People had chronic Lyme disease. 28:11 So you know that the politics, the dysfunctional medical politics 28:14 of Lyme, unfortunately, you know, is it a chronic, persistent infection? 28:18 Is it not a chronic, persistent infection? 28:20 What causes it? 28:22 It's hurt the Alzheimer's research also because it is 28:25 a chronic persistent infection. 28:27 And if you're going to deny that these biofilm persist,
Root causes, the 16-factor model, and treatment approach 28:30 your forms in the brain that create beta 28:33 amyloid, that increase Peto that are now being talked about for ever. 28:37 Shopee's group and doctor McCloskey, it's important to know that there may be. 28:42 Again, it's one case study. 28:43 We can't say much, but it's exciting because I didn't know 28:47 whether I was going to be able to reverse that. Pete out 2017. 28:49 It's never been done right. 28:51 So it's like, wow, maybe this is going to be something that will affect a lot. 28:57 Millions and millions of people may be able to get better from this. 29:01 But also the woman who was 80, who did low dose 29:03 DTaP, someone who said to me my memory improved, you know, maybe 29:07 in the in the study they did in Korea, it was 100 of them, right. 29:11 They treat leprosy with 100, not double dose, 200 not high dose 29:15 used for Bartonella maybe 100 of DAP shown is all people need. 29:20 Instead of worrying about the can of Mab in these drugs 29:22 that are very expensive and shrink your brain and cause brain bleeds. 29:26 So there's, there's, 29:27 I think new things we can talk about here that's really quite exciting. 29:31 But we chose the Neuroinflammation Brain Protection Summit and talk about 29:36 this was because of some of this 29:37 that is now showing up that when I started testing my Lyme patients 29:41 and seeing so many of them were starting to have these markers, 29:44 I have a 50 year old woman in Connecticut who's a professor. 29:48 She did a two week DAPs on pulse. 29:50 She had Bartonella. 29:51 I said to me, because she never wants you to do the full protocol. 29:54 She said, oh, I feel so much better. 29:56 I tested her her out to 181. 29:59 Marker was elevated. She's 50 years old. 30:02 And I said to her, listen, you got to follow up with your doctor here 30:05 and finish the protocol and look at the 16 factors. 30:09 But, you know, when we go to the doctor and you check your blood pressure 30:12 and you check your cholesterol, 30:13 and you go for mammography to rule out breast cancer and colonoscopies 30:17 and teach you to rest the exams with PSA for prostate. 30:20 It's not on the list of things your doctor normally does, which is to say, 30:24 how is my, how's my PTO and my beta amyloid doctor? 30:27 It's not standard medicine. Why? 30:30 Because they don't know what to do for you. 30:32 They have no idea if it comes back positive. 30:34 It's like, well, what do we do? 30:35 I'm suggesting that you go through the 16 point message model, 30:39 which has been published in the literature to be associated with dementia, 30:43 and then may be considered the nine week oral dapt, some combination therapy 30:47 and some of the herbs. 30:48 Right, Maria, that that you're using that also have scientific validation. 30:51 Right. 30:52 You know, it doesn't make sense to me when we can measure the markers 30:57 and we know that these markers, like beta amyloid and p tau 31:01 are reacting in response to an organism. 31:05 Right. What? 31:06 I just doesn't even make common sense to me 31:09 as to why we wouldn't go through and 31:12 look for all of the various organisms 31:15 that could be causing this response in the body, right? 31:19 Because then we would be doing real root cause medicine 31:23 instead of using a monoclonal antibody to kind of like clean up the mess 31:27 without turning off the sink. 31:29 You know, like to me, it's like using the lecanemab is like, you know, 31:33 we're we're mopping up the floor, but like, we haven't turned the faucet off. 31:36 That's making the sink overflow. 31:39 Exactly. Right. 31:40 It make it makes no sense to you or me, 31:42 especially because infections caused beta amyloid. 31:45 We talked about this in another podcast that the beta amyloid is protective. 31:49 Your body is actually creating it to try and shield off the organism. 31:53 Except the problem is, is it keeps accumulating. 31:56 It then starts to drive phosphorylated tau and the neuronal connections 31:59 just don't work overtime. Right. 32:01 But but you're right. 32:02 You root cause medicine in this case is going to be essential. 32:05 Especially with the numbers of Alzheimer's cases 32:07 that are expected to double in the next 25 or 30 years. 32:10 Yeah. 32:11 So tell our listeners a little bit more about these ten patients, 32:15 that you're going to talk to us about. 32:16 And do you want to say anything more about the study 32:20 and your paper that you've so the main thing about the paper 32:24 is that when I went through this patient, who is roughly 60 years old, 32:29 she had never won again, one of the few had never done daptone. 32:32 She had an elevated rheumatoid factor with joint pain, but CCP negative. 32:36 She did not have rheumatoid arthritis. 32:38 She had an elevated p tao 217 one of the most important markers 32:43 that, you know, gives you a chance of having dementia later on. 32:46 Again, 15, 20 years down the line. 32:48 And again, she wasn't even complaining of cognitive issues. 32:51 But she also, by the way, had two Bartonella species. 32:53 She, her Bartonella hensleigh and Bartonella quintana were positive. 32:57 She had evidence of exposure to Q fever. 32:59 Cox yellow Brunetti. 33:00 All of these organisms can be associated with amyloid production and dementia. 33:05 And she also had heavy metals we chelating her years ago for lead and for mercury. 33:09 So we looked for all these M sets factors, and we dealt with all the factors 33:14 that we could. 33:15 And she was doing so well. She would come in once a year. 33:17 She was at one of these chronically ill patients. 33:19 She would come in and go, oh, I got in a car accident. 33:22 I need a little physical therapy because my knees not working. 33:25 But she was saying, I'm all stiff, but, you know, I walk every day. 33:28 I'm doing great. 33:29 It wasn't actually until we checked these biomarkers 33:33 and the detail came back, and I didn't even think to do like a mini cog exam. 33:37 You can do these small, mini mental state examinations to check cognition, 33:41 because she wasn't even complaining of cognitive problems. 33:44 And lo and behold, we do the protocol. 33:47 Three months later, I check the quest Labs. 33:49 The number of the p tau 33:50 reversed down to normal first time published in the literature. 33:54 The rheumatoid factors now were negative, meaning we reversed 33:57 peripheral inflammation and theoretically reversed neuroinflammation. 34:01 Right. 34:02 So it's it's a really it's an amazing case study 34:05 because we have proof, for the first time ever, Shopee published 3 or 4 years ago 34:09 that we're finding beta amyloid pito and biofilms on autopsy. 34:14 Patients with Alzheimer's and Parkinson's. 34:17 But we never had an in vivo person who's alive 34:21 who took a biofilm, persistent drug regimen like that, 34:24 some combination therapy and said, well, okay, can we reverse these markers? 34:28 What happens? It's the first time. So it's huge. 34:30 But now I need naturopaths, eyelids, doctors, all the doctors out there 34:35 who are listening and all the patients listening. 34:37 Again, don't freak out because based on what I've seen, you probably 34:41 got about a 5050 shot that these markers may come back positive. 34:45 But just like if your cholesterol is elevated, 34:47 you're going to get on a diet and exercise program and you 34:50 might consider a stat new to reduced rice, whatever it is you're going to do. 34:53 Bergamo the point being, there are things you can do. 34:57 This is not a life sentence that my life is over, but 35:01 it does require now going through the 16.6 factor and it's Maria said. 35:05 You can check for chlamydia, pneumonia, you can check for H. 35:08 Pylori, you can check to see if Borelli Bergdorf Frye is active. 35:11 These are all things that you can do. 35:13 And then saying, okay, these biofilm persistent drug regimens. 35:16 Horowitz has been publishing on them for ten years. 35:19 I do have a consultation model and believe me, not looking for work. 35:22 As I told Maria earlier, before we got on, I had 75 emails 35:26 yesterday of people calling me from all over the world. 35:29 I published these articles in the peer review literature. 35:32 So it's open access. Your doctors can read them. 35:34 They don't necessarily have to contact me, but if they need my help, right, 35:39 I am available. 35:40 You just go on 35:40 the can get better.com website and look under the consultation service. 35:44 But all ten articles on them, 35:47 how it lowers down the biofilm persist your forms in culture. 35:50 The tough study 35:52 showing that we were able to cure Lyme in the mouse model, 35:55 when they failed oxy cycling and then the eight other studies 35:58 that we did, about 350 retrospective patients 36:01 showing that memory concentration, improve fatigue, improve joint pain, improve 36:05 muscle pain, neuropathy, improve fever, sweats, chills, but busier symptoms. 36:10 Mood. 36:11 We've published this all over the last ten years. 36:13 It's taken me about a decade to tweak the adaptation protocol to get it to be 8 36:18 to 9 weeks, and then if it's Bartonella, it's short term two week pulses. 36:23 And again, the full protocol are written out again, 36:26 apart from microorganisms, September 2023 and the journal microorganisms, 36:32 April 2024, when I have three case studies showing how, again, 36:36 we've reversed 36:37 the symptoms of chronic Lyme, I have a Substack called Medical Detective. 36:41 It's free to sign up the five Bartonella Substack that I did, 36:45 numbers four and five had the entire protocol written out in detail. 36:51 And number five is for the two week post for active Bartonella. 36:54 So I've got all of this out there published for you. 36:57 Your doctor can access it. 36:58 And if your doctor has any questions, please have them contact me at my email 37:02 medical at each VHA SI.com. 37:06 It stands for Hudson Valley Healing Arts Center. 37:09 Thank you. 37:10 So switching gears, a little bit, since Alzheimer's is the fifth leading 37:15 cause of death in Americans 65 and older, 37:19 and we also know that Medicare patients have up to seven times higher rates 37:24 than what is generally reported with Lyme disease. 37:28 What do you think HHS and the health department 37:32 should be doing at this point regarding this epidemic? 37:36 And the link, like the pretty blatant link between the two? 37:41 Yeah, I from my perspective, what HHS needs to be doing at this point, 37:44 because our Secretary of Health, Kennedy, 37:47 has really said he doesn't like the medical model. 37:49 Using in fact requires medicine. 37:50 I don't I've not had a chance to speak to him, 37:52 but I bet based on what I know from Casey Means and people around 37:55 him, well, you and I are discussing today a root cause medicine. 37:58 I mean, he focuses a lot on diet and exercise, which is great. 38:02 You know what? 38:02 We're in the middle of a Lyme epidemic, and the Medicare rates are seven 38:06 times higher. 38:06 So if the CDC is saying 6000 people, roughly a half a million 38:10 a year are getting Lyme, it's seven times higher in Medicare. 38:14 I don't know what that means 38:15 is at 3 million people per year in Medicare are getting Lyme. 38:19 And we know that Lyme has been associated with Alzheimer's, 38:22 where the rates are ten times higher and that they're finding on autopsy. 38:26 One quarter of all Alzheimer's cases under autopsy are due to Borrelia burgdorferi. 38:30 Lyme. 38:31 What it means for me, for HHS is get a randomized, multicenter, 38:34 placebo controlled study of dapt some combination therapy done, 38:39 and add these Alzheimer's biomarkers. 38:42 With Peter 181 Peter 217. 38:45 Amyloid 4240 ratios, neuro filament, light and epi status 38:50 to these five markers in a randomized, multicenter, placebo trial. 38:55 So you're not only looking at how is the fatigue, how is my pain, 38:59 how is my cognition? 39:00 You can measure it with, you know, some of the very short measuring like mini cog. 39:05 You can measure these things. 39:06 But now we can measure the biomarkers before and after. 39:09 And and if you do it in a placebo study, we will not only see 39:13 how well people do with chronic Lyme, but we will have an indication 39:17 whether we can in fact reverse inflammation in the brain. 39:21 Right. So it's blocking Elara. 39:23 Inflammation may be taking down the load of Borrelia in the brain. 39:27 We have a study that absolutely needs to be done.
Research, HHS action, and practical guidance for patients 39:30 I had submitted an R 34 grant last year. 39:33 I'm sorry to say it was turned down by the NIH reviewers. 39:37 I'm not sure Kennedy Kennedy knows this. 39:39 It took me four months 39:41 working with Eva Garland, consulting through my five and one C3. 39:44 We paid him 39:45 like $32,000 for me to get this study done and go through all the hoops. 39:49 They still denied it. 39:51 I was giving them it was a quarter million dollars I was asking for. 39:55 So now I have to reapply 39:57 and I have certain people I spoke to in the government 39:59 who are going to look for other funding opportunities. 40:01 But we've got an Alzheimer's epidemic. 40:04 We've got a Lyme epidemic. 40:05 HHS needs to look at this research that's been published right, and say, 40:09 okay, the time has come. Let's not put this off. 40:12 Let's get some reviewers on board, 40:14 basically who said, yeah, this is an important study to do. 40:17 Yeah, absolutely. 40:18 So what were your final words of advice be to our listeners 40:22 who either themselves or have a loved one that suffering 40:26 from chronic memory, concentration, focus their shoes? 40:30 What sort of work up? 40:32 I know we've already gone through it, but summarize what would you recommend 40:36 they do first and how do they talk to their physician? 40:39 So most doctors they'll 40:40 they're going to start with simple things like where's your B12 level. 40:43 Let me check your folic acid. How's your thyroid function. 40:46 Do you have hypothyroidism. 40:48 They're going to start with some of the easy stuff. 40:49 Get a CBC, a bio chem profile. 40:52 But ultimately what we found in doing this deep dive in the medical literature 40:56 is that all 16 factors that I've published for chronic Lyme 41:00 and that I published full on Covid are associated with Alzheimer's dementia. 41:05 So what you just need to do with your doctor 41:07 is go through all of these 16 factors. 41:09 The first six, by the way, of infections, environmental toxins, leaky gut, mast 41:14 cell activation, microbiome issues, sleep disorders, vitamin mineral deficiencies. 41:19 Those are the six. 41:20 I call them 41:21 the rivers of inflammation that drive or that cause an ocean of inflammation. 41:25 You go through those with your doctor piece by piece, 41:28 and then you look at the ten downstream effects of the inflammation. 41:31 Do I have mitochondrial dysfunction, which has been, by the way, 41:34 associated with Alzheimer's? 41:35 There are doctors out there looking at low dose methylene blue, 41:38 which we use in the Daptone protocol to reverse mitochondrial dysfunction, 41:42 because you're finding that some of these Alzheimer's patients are getting better 41:46 supporting the mitochondria without necessarily trying to pull out 41:50 beta amyloid. 41:51 So you look at the mitochondria, you look at your hormones, 41:53 you look at your thyroid, all of your hormones, by the way, 41:56 your adrenal sex hormones. 41:57 We know that when estradiol goes low in menopause, it affects memory and mood. 42:02 Right. So that's important to look at. 42:04 Especially the black box warnings were now taken off a recently by HHS because the 42:09 reanalysis was it was not quite as bad as they thought. 42:12 But you look at neuro issues, psychological issues. 42:15 Do you have fatty liver? 42:16 I check any of my patients who have elevated liver functions. 42:20 I send them for an ultrasound, and many times 42:22 they come back with fatty liver. 42:24 That requires weight loss. 42:25 But insulin resistance, right, is one of the causes 42:28 of Alzheimer's dementia and it's associated with fatty liver. 42:32 Just go through the 16 point message model with your doctor 42:36 making sure you're getting to sleep, exercising properly, keeping sugar 42:39 out of your diet, stopping insulin resistance. 42:41 But the point being, it's not a life sentence. 42:44 There are things you can do instead of just going to your doctor 42:47 and getting drugs like aricept, the Namenda or Lecanemab. 42:51 There's actually something you can do by going to the 16 point M6 model, 42:55 checking these biomarkers, and then using a biofilm, persist 42:59 your drug regimen like that. 43:00 Some combination therapy. 43:01 And the way I've always done medicine is what would I do 43:05 for myself or my wife if I had these markers? 43:08 That's what I would do, I would do. 43:09 My wife, at this point is eight years in full remission from the Daptone protocol. 43:13 She was sick for 25 years. 43:15 So I know that it's possible for people to go into long term remission. 43:19 This ridiculous debate is Lyme. 43:21 A chronic persistent infection has now implant right. 43:24 It's impacted even the Alzheimer's research 43:27 and our Alzheimer's of this epidemic. 43:29 We're having Alzheimer's also. 43:30 So it's just time to get a roundtable together 43:33 like they did for Lyme a couple of months ago with HHS. 43:36 And look at the data and say, we can do better. 43:39 So it's an exciting time. 43:40 And again, for people that are interested in reading about it, 43:43 this book from Simon and Schuster, Ending Chronic Illness, is 640 pages long. 43:49 I guarantee you anyone who doesn't like this book 43:53 and doesn't think it's useful, please send it back and I will refund your money. 43:56 At this point in time, you will not believe what I put in this book. 44:00 This book will help you with differential diagnosis. 44:03 It will tell you if you have resistant properly, why it's there. 44:06 If you've got resistance, migraines, resistant, GI symptoms. 44:10 Every major chronic disease is analyzed according to the 16 point model, 44:14 showing how all of the factors are there and it gives you natural supplements, 44:19 diet, exercise, natural ways of dealing with it, not just pharmaceuticals. 44:23 For me, it's the most comprehensive 44:25 kind of medical tome I've ever created, and it's kind of my gift for the world. 44:29 It's my gift for all of you who are suffering. 44:32 So I'm kind of excited for everyone to read it and tell me what you think. 44:35 But I think you're going to find it provides clues for chronic illness 44:39 that most people said, well, we can't really do much better. 44:41 And the fact is we can do better. 44:43 So this is about hope, right? 44:45 It's about hope and healing. 44:47 So I'm really excited to share it with everyone. 44:49 And the website is can get better 44:50 for the consultation service but ending chronic illness.com. 44:54 If you want to take a look at the book, 44:56 wonderful and the book should be out by the end of the year, 44:59 it will be out by October and I'll be starting book tours 45:01 and speaking engagements will be starting soon with Simon and Schuster, 45:05 and I'm starting to get on a lot of podcasts at this point. 45:08 Likely based on my talk with Mark Simon, I'll be flying out 45:11 to Austin, Texas to do a podcast with Mark about it. 45:14 So yeah, I'll be I'll be out there kind of talking to people 45:16 about what's in the book and, and basically how to use it. 45:19 That's great. 45:20 And everything that we've talked today, again, 45:22 it really does apply to all chronic disease. 45:26 And you know, we're talking about Alzheimer's 45:28 and we're talking about neuroinflammation. 45:30 But just think of all of the other neurodegenerative diseases and illnesses 45:37 that are, you know, have neuroinflammation as a piece of the puzzle 45:42 for their root cause, you know, so this can apply to things like A.l.s. 45:47 and Parkinson's and amass and right, and all of these other neuro 45:52 inflammatory, immune, dis regulating sort of driven phenomenon in the body. 45:59 This isn't just, this is and chronic fatigue syndrome, 46:03 myalgic encephalomyelitis and fibromyalgia share the same symptoms as chronic Lyme 46:07 as does long Covid, as does mold of fatigue, joint pain, muscle pain, 46:12 sleep disorders, neuropathy disorder, Nami with Pots, memory 46:16 concentration problems. So hold on. 46:19 If you've been diagnosed with chronic fatigue, fibro 46:22 and you have not checked these biomarkers that we're talking about today 46:25 of neuroinflammation and they're positive, maybe even if your chronic fatigue 46:30 and fibro was due to herpesvirus six or EBV initially, 46:34 how do you know that Lyme or Bart or mold or other things are not underlying it, 46:38 and that 46:38 this is something you can do to reverse potential cognitive decline later on? 46:42 I mean, it gives people 46:43 like a whole new map of looking at whatever your chronic illnesses 46:47 we even found with hiatal hernias, Crohn's disease, ulcer, 46:50 every GI disease I looked at, we looked at some of the big ones. 46:53 The GI chapter in this book has a that's 30 or 35 pages long on Sibo 46:59 and Cf0 and hiatal hernia and Crohn's 47:01 and all these diseases and how the M sits factors are underlying 47:05 what happens to your microbiome where to vitamin mineral. 47:08 So it's kind of like when you know this wood line 47:11 people don't come in which has Lyme disease. 47:13 They have all these overlapping chronic illnesses. 47:16 This is a way it's a different lens of looking at it. 47:19 And it's a paradigm shift, right, of how we look at chronic disease and basically 47:23 keeping us all healthier, hopefully, and and happier as the years go on. 47:26 So it's exciting. 47:27 It's not a gift I expected to get to the world. 47:29 It was an unexpected finding because when I got the contract 47:33 from Simon and Schuster, I didn't know that autism had all 16 factors. 47:37 I didn't know that ad, I didn't know that Crohn's had it. 47:40 It's kind of like, oh my God, nobody knows this. 47:42 I need to get this out to the world. 47:44 It's really exciting. 47:46 It's really Berlioz, you know? 47:47 And it's one of the things that I've been saying for years, 47:49 like if we just focus on killing these organisms and we think that 47:54 they're the only root cause are, oh, we finally found the root cause. 47:58 You know, I always say at one time 48:00 they were the root cause, but now they've changed the terrain. 48:04 They've changed the cells of every organ, every organ system in the body. 48:08 And so now you have to act like a detective and go in and figure out, 48:13 okay, what of this patient sitting in front of me? 48:17 What pieces of their puzzle? 48:19 How has their terrain been altered? 48:21 And now all of these things that you find are also 48:25 now root causes that have to be addressed 48:29 to be able to resolve the infections and reset the immune system in the end, 48:35 so that when you're done 48:36 with your antimicrobials, the infection can't just grow back. 48:39 Right. 48:40 And we're taking care of all of these viruses 48:43 that become so high because the immune system is in, 48:47 you know, keeping them dormant as they should be once 48:50 they've gone through their acute phase. 48:52 So I'm so excited to get your book and to read your book. 48:56 And it really like it proves my point that I've been talking about for years 49:00 that we have to address the whole person, all the pieces of the puzzle, you know? 49:05 And for you, that's that 16 point I'm model and it's just so exciting. 49:11 So thank you for putting that all together for everybody. 49:15 Oh, it's my pleasure. 49:16 And again, if you're a patient or doctor listening out there, please speak to your 49:20 physician today about these biomarkers that we talked about today. 49:24 I think very important. 49:25 I think just as again, you go for your blood pressure and your cholesterol check. 49:28 We're in the middle of a dementia epidemic, 49:30 and we specifically chose to label this conference the Healing Line 3.0. 49:34 But looking at neuroinflammation and protecting the brain, 49:38 because we now have ways of doing that in ways that we just didn't have before. 49:42 So thank you for posting. 49:43 Yes, I really appreciate it more. 49:45 Yeah. 49:45 And you know, this is such a scary disease. 49:48 And these are really scary statistics. 49:51 So to know that there is actually something 49:55 that you can look at as a marker decades before, 50:00 you know, the worst part of the illness and then something you can do about it 50:05 again, like the message from 50:06 this should really be, hope to all of you that are listening. 50:09 So absolutely. 50:11 Thank you everyone for joining us. 50:12 Thank you so much, Doctor Horowitz, 50:14 and we'll see you soon on another episode of the Healing Lyme Summit 3.0. 50:19 Take care. Bye bye.
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