Full Transcript Introduction to Dr. James LaValle 0:00 Welcome back to the Bioregulator and Peptides Summit folks 0:03 joining us today in we are so lucky to have him is Doctor 0:07 James LaValle, a clinical pharmacist, board certified clinical nutritionist 0:11 and one of the most respected voices in metabolic and integrative medicine. 0:15 He's got over 40 years of clinical experience. 0:18 James is the author of over 26 books, including the landmark 0:22 Cracking the Metabolic Code, which I'm pretty sure is one of the first books 0:25 I ever bought long before I was in this space. 0:28 And he's the mind behind the metabolic code, a model 0:31 for uncovering the hidden barriers to true health and longevity. 0:35 He currently serves as Chief Science Officer at Lifetime, chair 0:39 of the International Peptide Society, and he's the clinical co-chair 0:44 of the American Academy of Anti-Aging medicine, 0:47 otherwise known as a forum, 0:49 along with adjunct 0:50 faculty roles at the George Washington University School of Medicine 0:53 and for nearly two decades, the University of Cincinnati College of Pharmacy. 0:58 He's been named National Clinician 1:00 of the year and a Forums Educator of the year, and recognized 1:03 among the 50 most influential pharmacists in the country. 1:07 Now, given his leadership in peptide therapies and metabolic health. 1:11 There's truly 1:12 no one better to help us dig into the science of these small molecules. 1:16 We are so lucky to have him here. 1:19 So, you know, busy executive, 1:22 you know, phones going off, pagers going off. 1:26 I'm busy. 1:27 Get me through this mess. And then he gets through. 1:30 The end of the day, he's told that he has a coronary artery 1:34 calcification score of plus 700, which is pretty big, right? 1:38 He's pretty clapped up. 1:39 And he gets back to my crew, which is now going to do 1:42 the lifestyle nutrition support. 1:46 And the first thing he said to me was, he comes in like a tail dog with a tail 1:51 between his legs and he goes, I'm not going to have to eat tofu, am I? And. 1:58 And literally not, not, not the tofu is bad. 2:01 I guess if you if you air fry it or something, I don't know. 2:04 But anyway. But the point being is, I think 2:06 a lot of times people don't understand that. 2:10 Yeah. 2:11 Their numbers come back and they're shocked. 2:14 You know, many times they're shocked at, you know, their homocysteine is elevated, 2:18 their C reactor proteins up, their insulins out of, 2:21 you know, it's kind of trending in the wrong direction. 2:24 They're making a bunch of bad actor lipids or kidney functions off. 2:27 This is what I see all the time. 2:29 It's not like it's a rarity anymore. 2:31 It is commonplace. 2:33 And I think it's because people don't understand meta formation. 2:38 You know, we've been taught 2:39 you're if you're thinner, you're like, hey, my metabolism is good. 2:43 And, you know, metabolism is really the sum total. 2:46 All the biochemical reactions going on in your body right now 2:50 that have been created since the time you were born. 2:54 All those pathways in your mother's womb to now create your expression today. 2:58 And then it is influenced by what you do to yourself, right? 3:04 How we eat, how we exercise, how we sleep, 3:07 how we stress, how we love or not like all that stuff. 3:10 And then what the environment does to us mold, bio toxins, 3:15 environmental burden, glyphosate, Badwater or whatever. 3:19 Right. 3:19 And so because people don't think of it that way, they just don't 3:25 look under the hood and, and get that lab test and see what's going on. 3:30 I mean, just like basic advanced labs, I'm not talking about, 3:34 you know, going and asking for a toxic metal test or a pesticide test. 3:38 They don't even go and get things where they look at their advanced lipids, 3:42 or look at their C reactor protein or their homocysteine. 3:44 And these are core things that we know if they're elevated, 3:48 you are accelerating your aging. 3:51 I mean, that's the funny thing I've got about all the other stuff, 3:54 like biological age test, I think they're still being perfected. 3:58 I don't think they're there yet. 4:00 But here's what I know. 4:02 If you're glucose is spiking up and down by wearing like a CGM monitor, 4:07 or you have a glucose above 90 fasting, that alone means you're 4:14 probably going to be shortened in your longevity quotient. 4:18 Just that a pretty low bar, right? 4:20 Like the continuous glucose monitor, I think is one of the most powerful tools 4:25 people have at their disposal, just as a source of data.
Metabolic Health, Stress, and Hidden Lab Markers 4:29 Right? Yeah. 4:30 And I think where people get into trouble is it's even like 4:34 with sleep scores and stuff, they take it as a judgment and it's it's. 4:38 Yeah, exactly. 4:39 You know, like it's it's a data point. 4:41 And I think that especially with your high, our high performers, 4:45 these are people who they're doing a lot right. 4:48 But they're doing too much too hard and right. 4:54 Like honestly, you know, I 4:57 like, look, I just got really sick for a month. 4:59 And if I look back at the runway that led to that sick and it's not a direct line 5:04 like lots of other things contributed to this, right? 5:09 I didn't know what it was like to have personal time. 5:12 Yeah, I said me some shit. 5:14 Like I did not know what I forgot 5:18 what it's like to cook a meal for for my family or to stop. 5:22 That's huge. 5:24 Yeah. I mean, you know what? 5:25 I had to learn that, you know? 5:27 But, you know, I'm older than you, so I'm just telling you from the wise 5:32 old man in the sea here that I know. 5:36 Honestly, I had to. I had to learn. 5:39 You know what? After. 5:41 Because I get up early, you know, I'm still getting on it pretty early. 5:44 It's like there's no good that comes out of my brain after 630 at night. 5:49 I'm going to shut down, cook dinner, 5:52 sit down, relax, let my brain cool off. 5:56 And I had to learn that because I was big. 5:59 I was one of those, you know, I mean, I wrote 26 books. 6:02 I mean, you know, it's like one of those people, right? 6:05 You know, five databases. 6:07 I mean, it's like, what can I do next to show that I'm smart, right? 6:10 And not, you know, and not realize there's more to it than that. 6:13 And I think the high performers, I just know when we had the living Longer 6:18 institute people that we see would retire because they were like running 6:22 like a bull. 6:23 Very successful many times within two years ended up in a 6:27 like a coronary event or another event. 6:31 Yeah, yeah. 6:32 Like the system falls apart 6:34 because I think what happens is it gets over, it gets you. 6:38 Don't you know, 6:39 I came up with analogy for the human body and tell me what you think. 6:42 It's like a giant Jenga game and. 6:45 Well, and so you're, you know, as you go through life, 6:48 the little you're poking and it's a bit more confidence, you know. 6:52 Right. 6:53 But you're building you're building weaknesses. 6:56 But the cool thing about the human body is it compensates. 6:59 And it'll rob Peter to pay Paul any day, to keep, 7:03 to keep giving you what you want until that. 7:07 Right. 7:07 And I think that that that nervous tension, 7:10 that over performance that go go go go go. 7:13 It's like this electricity that keeps things moving more than they should. 7:18 And all of a sudden when you stop, there's like a coming of like 7:23 there's a, there's an accounting that happens. Yes. 7:26 And I think that's very well said. 7:29 You know, it's. 7:30 Yeah, I've spent a lot of time talking about the nervous system 7:33 these days, like parasympathetic sympathetic tone. 7:35 And people get stuck in sympathetic tone. 7:38 And your sympathetic nervous system is supposed to be kind of a pulsing 7:42 nervous system, not a full on nervous system. 7:45 And so when you stop that run for the white tiger, you know, hey, I'm retiring. 7:51 Well, now your body's no longer being asked. 7:54 It's like asking a racehorse to run at full speed forever. 7:58 Right? 7:59 We don't expect a racehorse to do that because they break down and then they get 8:02 either they get into Glue factory or put out. 8:04 And that's what happens with us. 8:06 Because if we push too hard, 8:07 too long, one of the values of peptides, one of the values of doing lab 8:12 tests, eating better nutrients, biomedical hormones 8:16 helps us put that dress back in the box. 8:20 If we're smart enough, you know, get the circuit breaker box, 8:24 get get all the fuzes it blue turn back on. 8:28 Yeah, but it still takes a you know, the biggest thing I try 8:31 to get people to understand is there are no shortcuts. 8:34 There's no. 8:35 And if we ever think there. 8:37 Yeah. 8:37 If we ever think there's going to be some fountain of youth pill, 8:41 we're way too complex. 8:42 There's too many inputs into our body. 8:44 You, you you do have to get back to that accountability. 8:47 Like what you were saying earlier. 8:48 If you don't do that and then apply 8:52 sensible tactics that you can say, 8:55 I feel better, I'll keep doing that, I feel better. 8:59 That's kind of how I know. 9:01 I mean, honestly, I know it sounds wobbly. 9:02 I have people coming to me all the time and bringing in 9:04 like 30 bags of stuff they're taking, like, what? 9:06 Do you feel better? 9:08 No, but they were so nice. 9:10 Well, know that you're the only. 9:13 The only metric we use is are your lives better and do you feel better? 9:18 And what are your symptoms? 9:20 Are they going away? Are you sleeping better? Are you. 9:22 Are you not crashing midday? 9:24 Are you thinking clearer? 9:25 You know. 9:25 Do you still have your your your joint swollen still, you know, 9:29 and I think we people are desperate out there. 9:33 And so they're just trying all kinds of stuff and we just lose that thought of, 9:37 you know, we got to get our bodies out of that chronic duress and stress response. 9:42 And Xanax isn't going to do it. 9:45 No, no, 100%. 9:47 It's the above the line below the line. Right. 9:49 Data is above the line and how you're feeling. 9:51 Well, data is below the line. 9:52 And how you're feeling performing is above. 9:54 So let's go back to your metabolic model, which is your 9:59 you know, it's one of your big things. 10:01 So you describe your work as finding the metabolic roadblocks. 10:05 Right. 10:05 So there's these things that people bump up against. 10:08 And sometimes they do 10:10 what they're supposed to and sometimes they just keep bumping. 10:13 So who was the what was the first patient pattern that you saw 10:16 that made you realize that the system was just missing it? 10:19 Like they were just missing the point? 10:22 Yeah. 10:23 You know, it's interesting probably 1993, because I did my first lecture on it 10:29 in 97 and then wrote the book Metabolic Code in 2002. 10:34 And now the new editions coming out. 10:36 I think I own you, a book from a long time ago. 10:39 Yeah, yeah, it's a long time, but it's still very relevant. 10:42 But because I don't think it's things have changed. 10:45 Here's what I found. Wow. 10:47 So you're stressed out. 10:49 Your cortisol is elevated, 10:50 your insulin is up, your glucose is up, and your thyroid is down. 10:55 You're tired. 10:55 You're gaining weight, and you crash midday. 10:58 And now you can't control your hunger and appetite. 11:01 And this is why. 11:02 Because as cortisol goes up, insulin receptor sensitivity goes down. 11:07 You release more insulin, you store fat, and as cortisol goes up, 11:11 you make more inflammatory compounds in your brain. 11:14 And now all of a sudden 11:15 you got neuroinflammation and cognitive cloudiness, mitochondrial loss. 11:20 And as cortisol goes up you lose T4 to T3 conversion. 11:24 And now your cells can't power the mitochondria 11:27 because you don't have by right hormone T3. 11:29 And that's why. 11:31 And that was the like the the layup. 11:34 Because I kept explaining to people why they had cravings. 11:39 You know like the why does the reward cascade occur. 11:43 Because look I mean it's the same as it was before. 11:46 Everybody was struggling with their weight. 11:49 It's 42 is 40 years ago, 42 years ago. 11:52 Everybody's struggling with their weight. 11:54 Everybody's can't figure it out. 11:56 Exercising more and eating less wasn't getting the weight off people 11:59 until they went into a starvation medical diet at 800 calories. 12:02 And then they got ghrelin rebound, and then ended up eating their way back 12:06 to being overweight again, you know, and and so from there, it just started. 12:12 I just started, you know, realizing that our body is just a system of systems, 12:16 just as you had said earlier, you alluded to 12:19 and you're only as good as your weakest organ. 12:22 Yeah. 12:22 And you can't like, I just saw something come out, which it was on YouTube 12:27 or something, but it was a presentation on the heart 12:31 gut kidney connection. Right. 12:34 So there's all these connections you can make. 12:37 I just modeled it in a way that was in the literature. 12:41 So, you know, adrenal, thyroid, pancreas is about cortisol 12:46 insulin, glucose and thyroid hormones and then got immune. 12:51 Brain is about the relationship between the crosstalk signaling 12:55 between the brain and the gut and the immune system being the mediator. 12:59 That and when it gets skewed, moods change. 13:03 Inflammation occurs in the gut, gut gets permeable. 13:06 More allergies, more inflammation. 13:08 You know, you trigger your your your microglial cells in your brain. 13:12 So what I did was I define these networks, looked at labs 13:17 and had all my grad students for about ten years look at things. 13:21 Yeah, I love I love grad students. 13:23 Well, they're all smarter for I to I mean, look, at the end of the day. 13:26 Everybody knows together. 13:28 Right, exactly. No. It's great. 13:31 And so what I did was I started to look at cross correlations because, 13:35 you know, I love this thing of we test 200 things. 13:39 We test, you know, it isn't how many things you test. 13:44 It's if you can identify the patterns 13:47 of dysfunction within the labs. 13:50 We're still a little archaic. Oh, your glucose is up. 13:52 That's bad. 13:53 Your D is down. I'll give you that. 13:56 And what I really set out to do was do what's called Bayesian modeling. 14:01 Just accelerated lab pattern identification 14:04 using five networks people learning phis and threes. 14:09 I, I partially did it because I wanted people 14:13 to quickly understand what I was trying to convey to them. 14:16 Where are you? 14:17 Metabolically broke. 14:18 Hey, you're adrenal thyroid, pancreas. 14:20 We call that triad one that's out of control. 14:23 You got you scored high both on symptoms and labs, and they came together. 14:29 And this is where you're broke. 14:31 And this is why you feel tired today. 14:33 You've gained weight, you're sluggish, and you can't control your appetite. 14:38 So what do we do for that person? 14:39 Just to see if it's being driven. 14:41 So if it's being if it's being driven strictly by stress. 14:46 Right. What what do we do. 14:48 No other triads are involved. 14:51 And I'll talk about how that progresses in a second. 14:54 Give them something to dampen their stress. 14:57 So are you 14:57 someone who's stressed in craves food, or are you stress and perseverance? 15:02 If you persevere, rate. 15:03 You're more of a person, maybe an asshole gone to person. 15:07 If you're a craver, maybe you need during the day. 15:10 The biggest problem people do is they don't understand. 15:14 You have to dampen your stress all day long to not be running from a white tiger. 15:18 So something like 15:20 ashwagandha, holy basil. 15:22 That's the dampen your stress. 15:24 If it's out of kilter, you're having cravings. 15:27 If you weren't having that, hey, I don't have any symptoms. 15:31 I just know I'm running really hard. 15:33 That's more like the adaptogens, 15:34 like ginseng and ashwagandha or ginseng and rodeo, right? 15:38 I'm protecting against the future break. 15:41 And then if it's glucose and insulin, obviously. 15:45 I mean, GLP ones are super popular now because people got too far. 15:50 They ignored all this and now they're glucagon was unopposed. 15:54 But there's a lot you can do before that. 15:56 You can get people on modified, low carb, low allergen, anti-inflammatory diets. 16:00 You can get them moving. 16:02 You can get them getting their chromium peak magnesium and zinc. 16:08 Several things will help. 16:09 The ancillary receptor berberine can do it. 16:12 You know, bitter melon can do it. 16:14 And then you can move to the PEPs, 16:16 like if you need a peptide because you tried everything 16:19 and nothing budged on your weight, well that and your glucose is still off. 16:24 You know, like nothing is working. 16:26 Yeah, fine. Yeah. 16:27 Move to it. Or if you're significantly overweight. 16:30 And then of course for thyroid, a lot of times for me 16:33 when we correct cortisol, when we correct cortisol, thyroid kind of comes back. 16:39 Because what happens is I think, you know, thyroid is the dog wagon, the tail. 16:43 It's the HPA axis that's doing it right. 16:46 It's the hypothalamus pituitary adrenal axis telling you. 16:50 Right. 16:51 Like literally doing job. Yeah. Yeah. 16:54 And you said it beautifully. 16:55 Your body is a system of countermeasures. 16:58 It'll rob Peter to pay Paul. 17:00 It's slowing down your thyroid because the cortisol 17:03 that's releasing the adrenaline is making your heart rate go up. 17:07 And your body's intelligence knows we only get so many heartbeats as males. 17:12 So there's an intelligence to this that's there. 17:16 And then of course when your stress gets bad enough and your gut gets 17:22 permeable enough and now you're making more lipopolysaccharide in the gut, 17:28 the lipopolysaccharide attaches to the thyroid and creates 17:32 Hashimoto's food antigen induce thyroiditis. 17:36 So that's triad one. 17:38 Adrenal fibroid pancreas stacking on triad two got immune brain. 17:43 So what I try to do is just create more elegant ways for people 17:47 to quickly understand how they can utilize integrative strategies. 17:52 Yeah. 17:52 And that's that's the whole purpose of hey, fix this one 17:57 that's broke and it may have a downstream effect on everything else. 18:01 And what I've and you know, we've been fortunate. 18:04 It's it's so funny when I first adopt I first started talking about this earlier. 18:07 He's like, oh my God this is so complex. 18:10 Now everybody because of the last 18:12 five years of kind of systems biology is coming around. 18:16 People go, wow, you made this really easy. 18:19 It's the same, exact same program. 18:22 I mean, we've created more and more advanced rules 18:25 because as we learn and see thousands of patients doing it 18:28 well, we're finding the rules and allowing that to happen. 18:31 But it's actually been great because what you're doing is 18:35 every symptom could go into a buckets 18:38 of different organs of the body, right. 18:41 So when you answer that one symptom question, 18:44 it's moving with different weight in a lot of directions. 18:47 Same thing with labs. 18:48 And then what you're doing is you're you're pooling 18:52 those labs together like a string of pearls. 18:55 Your glucose is 95. 18:57 All right. 18:57 60% risk of being diabetic. 18:59 But your insulins ten your C reactive proteins three 19:03 your kidney your GFR your kidney filtration is 60. 19:07 You have a 130 over 90 blood pressure. 19:10 Right. 19:11 You all and you're making bad after lipids your LDL particle size 2000. 19:16 Yeah. 19:16 Everything's like I really better work 19:18 on this insulin resistance because I just strung together 19:22 all the things that says I'm way down the funnel, way down the funnel. 19:28 And that's metaphor. 19:30 You may not be feeling anything, 19:32 but you're already down the funnel getting ready to hit that inflammation. 19:37 Because for all of the ballyhoo, we're going to live the 125 19:43 you know, 19:43 all that excitement I can't get right now. 19:46 We can't get an average person
Metabolic Code and Systems Biology 19:48 live past 77 in the US, 19:49 and the last ten years is riddled with tons of meds that they aren't 19:53 feeling really that great. 19:54 So can we please just start with moving the needle 19:58 to an 80 year old, healthy individuals and average person? 20:02 We get there and I'm all for living like I want to live long. 20:08 Sure it is, but sure. And who feels good? 20:11 We're missing it. 20:12 Yeah. No, I'm all in with you. 20:14 So I love this. 20:15 And do you think I. 20:17 You're going to leverage AI to make this even more simple? 20:20 Oh, I already am. 20:21 You already am. 20:22 Okay, that's what I'm thinking. What am I thinking? 20:25 I that's what we do. 20:26 Yeah, yeah. 20:28 Do is you have the black box and you leverage the AI over on over top of it. 20:33 So that because you have 20:34 the complexity of the rules and then the AI gets to refine the rules. 20:38 Because the problem is when you start with AI, 20:40 there's so much crap out there that you start getting dirty. 20:44 Yeah, yeah, yeah, yeah. 20:45 You got to be disciplined with the AI. 20:47 But I do like you can like the good of AI is really good 20:53 and the bad is really bad. 20:55 So and it's going to 20:57 it's like anything else, you know, 20:58 it's like it's comes down to the person using it. 21:01 Absolutely. 21:02 They have discernment and the knowledge and the wisdom to understand 21:06 if they're getting crap or are they getting quality back. 21:10 Okay. 21:11 So where do clinicians and bio hackers both over 21:15 complicate things and where they oversimplify it? 21:19 Where are you seeing this? 21:21 Well, I mean, I think the bio hackers just think like, 21:25 oh, I take this for this pathway and that's going to make it happen. 21:30 Whereas there's a convergence of what we've been doing, 21:34 genetics and pathways that are going on in human beings. 21:38 It isn't like I'm going to do these five peptides. 21:41 It's fixing these five things, and then I'm on my way. 21:45 And so I think that's one area is over 21:48 simplification of downstream and upstream events. 21:52 I think also not far enough upstream and downstream like people only go so far. 21:58 Right. 21:59 They don't go to I, they don't go to the end of the line. 22:03 And if you don't understand the end of the line, 22:05 not to mention the forks in the road, you can kind of create, 22:09 I think you can create overexpression on one side, 22:13 or you can create a block somewhat like, you know, like there's, there's 22:18 we and I've and I'm and I'm going to speak from the inside 22:20 because I would have been a bio hacker for quite a while. 22:23 I've stepped away from it to a point. 22:26 And I think, and I've learned this from talking 22:29 to people like you and Elizabeth and all these people that, you know what? 22:34 If you don't get the whole pathway, if you don't get to the end of the road, 22:38 you don't get the pathway. 22:39 And then you've got to understand what are the other 22:42 inputs into the pathway, because the other things you're taking 22:45 could be impacting those as well. 22:46 Like it's, it's, you know, it's it's both beautifully elegant and wildly complex. 22:52 And to your point, the just take this so that you can do that 22:56 and you stack ten of those on top of each other. 22:59 You've you've now possibly created a muddy soup that, 23:03 yeah, if you're lucky does nothing or. 23:06 Yeah, worth doing something bad. Yeah. 23:08 But you know, I mean honestly what I found 23:11 and I look, I, I work with two populations, kind of like 23:15 high performing people that would kind of be their self-proclaimed bio hackers. 23:20 And I look at myself like pharmacy like a good like I was trained before. 23:25 You're allowed to have calculators. 23:26 We had to make all our own compounds. 23:28 We had a we took. 23:30 Yeah, we had to take 23:31 I mean we had to take where medicinal chemistry understand receptors. 23:35 Right. 23:36 I felt like I was trained as a bio hacker, but I don't really I'm not really that. 23:40 I'm just a clinician that is trying to figure out 23:44 what receptors are on off and how do we turn them back 23:49 to their proper position to create homeostasis. 23:54 It's not about. 23:55 I think a lot of people will mess up. 23:57 They go, optimize, optimize, make them loose mitochondria with them 24:01 like racehorses. 24:02 It's really about homeostasis. 24:05 You just want to create balance in your chemistry, because a lot of times 24:09 people were taking things like mitochondrial peptides 24:11 and they haven't even repaired the mitochondrial cell membrane yet. 24:15 They don't even. 24:16 So they're just leaking a bunch of free radicals. 24:19 And and you know, it's there 24:21 once again, whipping that racehorse that's already ran two miles too long. 24:25 And instead of a step by step progression of understanding, 24:31 what is the what are you trying to accomplish from top to bottom? 24:34 Let's unpack that a little bit because I think that's really important. 24:37 Right? 24:37 I'm going to jump around a bit here because we're not a side section. 24:41 I don't care like when it comes to know because mitochondrial peptides 24:45 are like my pet peeve, right? 24:46 Because Mozzie, on paper, 24:49 you read about it, you're like, I want that, I need that. 24:53 It's going to help me to lose weight. I'm going to be better at the gym. 24:55 Everything in my life is going to be better. 24:58 Go get me in it. Fit me in it. 25:00 How much do I take? How much do I need? 25:02 And what you just said is so critical 25:06 to the equation that the way I my you know, again, I'm 25:10 talking analogies because I'm not a pharmacist, but and just for the record, 25:14 I think pharmacists in this space are the most valuable are MV Pete's 25:19 because you guys get pathways so better than anybody else. 25:22 But you know, if your mitochondria to 25:25 your point is not primed, it's like gunning an engine that's gunky. 25:30 That's out of all that's full of junk. 25:34 And our plugs are missing right. 25:36 What's happening? 25:37 You're you're destroying the engine. 25:39 So maybe we can help without going into, you know, exhausted tail, 25:44 but help people to understand before you go gunning your mitochondria, 25:48 because you may have mitochondria that's underperforming. 25:50 And to your point, we want them to over perform. 25:53 We want them to just work because when they work they're freaking awesome. 25:57 So so what what's the order of operations? 26:01 What are the steps people really need to take, 26:03 and how do they kind of figure out what they, you know, that they need this 26:07 before you go to the gunning the engine with the something like 26:11 and I just want to bring up the reason they go to like getting the mitochondrial 26:15 peptides right away is because at the bottom of the funnel of metal 26:22 is the loss of mitochondrial 26:24 biogenesis, you lose mitochondrial production, 26:28 you have ragged mitochondria, you lose your NAD to NAD ratio. 26:35 And that makes you more prone. 26:36 If you get a virus or a bug or an insult, you make more inflammatory cytokines 26:41 right away, right? 26:42 So that so at the bottom of the funnel is, hey, my cells don't make energy. 26:47 So yeah. 26:49 So if you're so thinking about mitochondria I think I always start 26:53 with phospholipids like your your mitochondrial inner 26:56 membrane and outer membrane phosphatidylinositol phosphate title 27:00 or the inner membrane choline outer membrane. 27:03 And it makes sense because if we have environmental burden 27:06 or excessive inflammation, our cell membranes 27:10 are getting damaged because of inflammatory signaling. 27:13 And that inflammatory signaling can come from being exposed to something 27:18 like an environmental toxin, LED mercury and whatever mold, right. 27:24 Anything. 27:24 It could be a line, it could be excessive stress 27:28 that is now broken my gut down and now I'm leaking. 27:33 I'm making lipopolysaccharide. 27:35 The breakdown of the bacteria releases that into your tissues, 27:40 and it attaches to your tissues and organs, 27:43 and then releases the signal 27:47 to increase inflammatory cytokines, which damage your cell 27:50 membrane, compromise the signaling into the mitochondria. 27:55 And one minus is signaling. 27:57 Because of excessive damage occurs, telomeres shorten. 28:01 So telomeres in mitochondria are going like this. 28:05 And so the first step is phospholipids repair the membrane. 28:11 The next step I would do is make sure 28:14 I have adequate magnesium CoQ10. 28:17 Yeah. 28:18 You can obviously look at mitochondrial catalysts like your life in a 28:21 if you want PCBs 28:24 amazing and clean own especially if you use it in the 28:28 in the micro version because it absorbs better. 28:31 Really good for acting as primers to get that Krebs 28:35 cycle mitochondrial function moving again. 28:39 Yeah. Right. 28:39 So and there's other there's a few other nutrients to but those are key. 28:43 Yeah. 28:43 And then once you get you kind of the membrane you're 28:47 providing nutrients to the mitochondria that they need right. 28:51 So we're feeding we're feeding. 28:53 And then you want to think about well 28:57 what's damaged them to begin with. 29:00 Did you take out take away the source of the insult 29:04 because you can pump all the nad mo USC you want into somebody. 29:10 And if the source of the sources of the damage 29:14 are continuing to play out, well, you're just going to keep getting 29:19 damage. 29:20 I mean, I think Henry Patel's me screen is really interesting because of it. 29:25 You know? 29:25 I mean, I think it's interesting that it does a good job of scoring, like where 29:29 your mitochondria kind of broke, but then but then the job is, 29:34 you know, I was so fortunate to have mentors 29:37 that screwed my head on right and said, do it in organized way, Jim. 29:43 Idiot. 29:43 That's how they said it to me, literally. 29:46 And it was it. 29:47 Did they have bio toxins and mold exposure? 29:50 Has it created epigenetic changes in the immune system 29:53 that you need to fix on that? 29:54 First you need to soak up the inflammations out of the liver. 29:58 What what do you need to do. 30:00 Is it metals, pesticides you know, got dysbiosis. 30:04 Is it all of it. Email you of it. 30:06 And if it is how order that correctly 30:09 so you can unwind the source and you you can get by. 30:15 You may need to support mitochondria 30:19 when you're trying to get rid of the source activity, because you need 30:25 mitochondrial energy in order to do and to run your immune system. 30:30 So that's where you think of, you know, 30:34 you know, SS 31 or Motsi or NAD 30:38 or or injectable nicotinamide ribose side. 30:42 You, you start to nurture those mitochondria. 30:45 But you kind of have to repair the mitochondrial 30:48 cell membrane, get the nutrients that it needs. 30:52 Calm down. 30:53 While you're doing that, you should be at least 30:56 cleaning up like really gross inflammation signaling. 30:59 My cortisol is high. 31:00 Because I'm stressed out and I'm not sleeping fine. 31:03 Correct that right. Here. 31:05 Take these things during the day. 31:06 Here's what you do at night. Get your stress under control. 31:09 Get your glucose under control. Get your insulin under control. 31:12 Get those main drivers of meta inflammation under control 31:16 because they may not be ready to do like serious detoxification 31:19 yet like it's a process to get people there. 31:23 Now sometimes people are in really bad shape. 31:25 They have Parkinson's or which, 31:26 you know, obviously a mitochondrial disorder, right?
Mitochondrial Repair and Recovery Priorities 31:28 They have Parkinson's disease or they were getting ALS or dementia. 31:33 That's when it's really in bad shape. 31:36 And you may not have the luxury of, you know, doing it step by step. 31:39 You got to jump in faster, harder, 31:42 make more dramatic, you know, you know, programing to help that person. 31:46 Correct. 31:46 But I think the biggest thing that we see is people go, oh 31:51 if taking my C's good. 31:53 Taking Motsi with SS 31 with NAD with CBN two for one. 32:00 One is gotta be good right. 32:03 It's like more more and more and more and well 32:06 and I'll take a higher dose or I'll take it. 32:08 Yeah. Or I'll take a higher dose. 32:10 I'll take it more often or whatever the case may be. 32:13 So all right I know we're not talking about quick things, 32:17 but if you have a quick win lever for the person who's kind of stuck 32:21 in inflamed right now, like their sleep or is it sleep, is it glucose, 32:25 glucose control recovery or the stress physiology. 32:29 What's what's the for the person who's the number one thing driving it. 32:32 Because you can't because you can't separate. 32:34 As soon as your stress is out of control, your glucose is out of control. 32:38 And if your glucose is out of control, you're driving more cortisol. 32:40 Because every time your cortisol, every time you eat 32:43 and you spike your glucose, you spike your glucose. 32:46 The most inflammatory event that leads to heart disease 32:49 is postprandial spikes in glucose. 32:51 And cortisol is released at the same time. 32:54 So there's so to me, like if you take out environment, what we've lost is eating. 33:02 You know, first of all we eat too much. 33:04 We eat too often, we eat too late. 33:05 We picked the wrong foods. We don't move. 33:08 I mean, we jump on our golf cart, 33:10 jump on our golf cart to go get the mail at the end of the driveway, right? 33:13 I mean, we order our food. 33:14 We don't even go to the grocery store and walk around, right? 33:18 I mean, it's crazy. 33:19 So I think back to living like the human. 33:23 You know what? We talked at the beginning. 33:27 You know what? 33:27 I'll tell her. I'll tell you. 33:28 This is another I can't help because. Cracks me up. 33:30 Got this. 33:31 Whoop. 33:31 I'm always doing this stuff because of my role 33:33 at lifetime, being a two science officer 33:35 for a lifetime, I'm always looking at all this stuff. 33:37 And you can get wound up in this and, you know, it's like, 33:42 it doesn't matter what I do. 33:43 I can't get to the 100% sleep thing because I never sleep 33:45 more than seven hours. Seven hours is my sweet spot. 33:48 I'm 95% efficient. 33:50 I sleep stress free. 33:52 Why am I worrying about getting to nine hours? 33:54 That stresses me out. But. 33:57 But anyway, I get my I do my workouts and I have a strange score on a hoop. 34:03 They give you a strange score and yeah, it's 1716. 34:07 Maybe a hard work out. 18 I buy a house. 34:10 It's got a fence around part of the backyard. 34:13 I have this big zero radius turning works. 34:16 It's a pretty big property. 34:18 It doesn't fit through the through the gate into the backyard. 34:24 Yes, yes, I love that thing. 34:27 Yeah, exactly. And I so I bought a writing. 34:30 I mean, I bought a push mower. 34:32 I thought I'm going to get a push mower, I'm going to push mo. 34:35 And I just really because everybody used to push mow. 34:40 Everybody used to have a lot more about the push. 34:42 I got done push rolling, and my strange score was just as high 34:49 as if I had done a moderate, slightly 34:52 hard workout because I kind of fair amount. 34:56 But you see, that's what we've cut out of our life. 34:58 Yeah, I remember I, you know, if I wanted something, 35:00 I had to walk about a half a mile up to the corner store. 35:04 I had to cut the grass. 35:06 I rode my bike. Right. 35:08 We don't do any of those things now. 35:10 And I think that so lifestyle combined with, 35:16 you know, stress, blue light like emails. 35:20 People say things on text, you get all wound up 35:23 and you take it out of context and you're like jacked up at somebody. 35:27 We have all these triggers and buttons that hit us, man. 35:30 I mean, the, you know, everything from that to traffic. 35:34 Yeah. 35:35 The stress response to me is the beginning of metaphor for most people. 35:40 Yeah. I think I would agree with you there. 35:43 It's it's the root right and primitive nervous system in a modern world. 35:48 And frankly, it drives the eating sometimes. 35:50 And like, it's the thing that it stops you from sleeping. 35:52 It drives the eating, it paralyzes you, whatever the case may be. 35:56 So I think I will. 35:58 I'm gonna I'm gonna concur with you. 36:00 So if you only had five markers 36:05 to spot early inflammation risk, what makes the risk the list? 36:09 I think we've already talked about this. 36:10 So you can go through this really quickly. 36:12 Cortisol even morning cortisol doesn't 36:15 have to be a morning cortisol before 9 a.m.. 36:18 Yeah. 36:18 Glucose insulin C-reactive protein 36:22 and homocysteine because the other ones that I think are important 36:27 all were a reflection of when those ones are bad. 36:30 So your kidney function goes down 36:32 when cortisol, glucose and insulin and homocysteine are up. 36:35 Lipids get bad when you're insulin resistant 36:38 and you make a lot of cortisol, right. 36:39 So a lot of the other inflammatory markers to become like downstream from those, 36:44 you know. 36:45 Yeah. What about DHEA. 36:48 Talk to me about that. 36:49 I mean I love the he is a is a marker because it's 36:53 because obviously if your data is good, it means your brain 36:57 is being protected from the ravages of elevated cortisol. 37:00 Right. 37:01 The DEA protects, you know, the hippocampus 37:04 from being damaged by cortisol. 37:08 So when data tanks, it means that a, you're 37:14 using up your reserve to make sex hormones and protect your brain 37:19 because you're using it for cortisol, 37:21 you're using it for sexual moans, you're using it for metabolism. 37:24 So when it goes low, I mean, I think it's an important 37:27 marker DHEA sulfates an important marker. 37:30 Yeah. 37:31 And so that's that ratio between cortisol and DHEA. 37:35 Like if cortisol is high you need that DHEA there. 37:38 And then the big thing I tell people is when it gets bad enough the court 37:42 that the ratio gets low because your cortisol, your awakening 37:45 response drops and you're out of data. 37:48 So it's kind of a biphasic thing, right. 37:52 Where initially the cortisol to data ratio when it's really big is bad. No. 37:58 Yeah it's bad. 37:59 And then but when at the end point at the end 38:02 point right where that's low, that's really bad. 38:05 That means the immune system is a mess. 38:08 You know you've got your neutrophils are low. 38:11 You can't respond to an illness. 38:13 You find yourself run down from working too hard not taking any personal time. 38:19 And then all of a sudden something hits you and you go wow. 38:25 Yeah, yeah. 38:26 That's interesting. 38:27 It's funny, we don't talk about Da that much. 38:30 And it's it's a very interesting little molecule that is plays a big role. 38:34 So we talked you mentioned advanced lipid markers before. 38:37 I'd love to like unpack those a tiny bit for people before 38:41 we get to our next section. 38:42 So little a Appleby LPL two like when do they when when do you see those things. 38:48 And you're like, oh this this we got a good. 38:51 Yeah. 38:52 So I mean once again LPA somewhat hereditary. 38:56 But I don't agree that you can't change the number. 38:58 I mean I've seen plenty of people where we changed their lifestyle, 39:01 got them on nutrients, 39:03 got their insulin resistance under control and that number dropped. 39:06 Interesting. 39:07 So so you look at it lipid particle size 39:10 the size of your LDL cholesterol pretty important. 39:14 And the way I explain it, it's like you have a tennis net 39:16 on the inside of your arteries and it's tennis net. 39:19 And how many softballs can you throw to a tennis net? 39:23 Not many. Yeah. 39:25 And then how many baseballs can get through a tennis net? 39:28 Yeah. 39:29 Still not many unless you throw really hard. 39:33 What about a ping pong ball? 39:36 Yeah, well, ping pong ball might get through, 39:41 but what if you're throwing into a tennis net? 39:45 Yeah. 39:45 And so LDL particle size, the more that you make inflammatory chemistry, 39:52 the more insulin, the more cortisol, the more insulin resistance, 39:57 the more BB sized LDL cholesterol you make. 40:01 And you can just throw them right through the inner lining of the artery. 40:07 And when your cortisol is elevated and your sympathetic dominant, 40:13 you make more inflammatory macrophages 40:17 which attack that lipid that got in there. 40:20 And then you create calcification. 40:22 So the particle size is important. 40:26 That's one. 40:27 Yeah. 40:28 Now the lipoprotein fractions are a reflection of inflammation. 40:33 So apolipoprotein B 40:36 is a pro-inflammatory lipoprotein. 40:39 So you don't want to make a lot of that. 40:42 But it's the same issue. 40:44 It's like you know and look one of the things that happened 40:47 it's age dependent is women lose their estradiol 40:51 and progesterone and testosterone and men lose their testosterone as they're aging. 40:55 That's influencing a lot of this, too. 40:59 So, for example, even women not to digress, but even women 41:02 for for mitochondrial function, estradiol is critical 41:07 to function. 41:10 Yeah. 41:10 No, I mean, so so the point being is hormones 41:13 start playing a role in these Vance lipids. 41:17 So then you have LP two, 41:21 which is kind of a carrier for oxidative compound. 41:25 The best way to think of it it's a bucket. 41:27 It's trash bucket. 41:28 And and you know the higher that is and I tend to look at it like, 41:34 hey, if you're approaching the like upper third, lower 41:37 fourth quartile of normal, it's kind of getting bad. 41:40 You know, the way I always tell, I try to give it to people. 41:43 If you're a mile away from the Grand Canyon, you take a single step. 41:46 It's not a big deal. 41:47 Take a single step when you're a mile away from the Grand Canyon. 41:50 But if you're on the edge of the Grand Canyon, you take that same single step 41:53 that not such a good outcome on that single step. 41:55 And that's how your labs are. 41:57 So how close are you moving 42:01 to creating more catastrophic issues 42:05 and and so, so LP two you get up in that fourth quartile. 42:09 It's like, hey, we ought to be cleaning up that insulin resistance. 42:13 Where is the inflammation? 42:15 Where is the metabolic inflammation coming from that's 42:18 driving the production of these bad actor lipids. 42:22 Now lipoprotein little A is gained a lot of popularity 42:26 because it turns out it's an independent risk factor for an acute event. 42:32 You could have perfectly clean blood vessels because we're brainwashed 42:35 into thinking, oh, it's all about the plaque. 42:39 Yeah. 42:40 It's not, you know, and you did have perfectly clean pipes 42:44 and your LPL, your LP little ways up and you get to have a coronary event. 42:49 You're still at risk. 42:50 And now history of diabetes, family history of diabetes 42:54 certainly influences that one. 42:56 So but a lot of times people don't get those. 42:57 They just get like LDL, HDL, total cholesterol and triglycerides. 43:02 Oh yeah. Everybody. Yeah. Yeah. 43:04 Everybody should get an advanced lipid panel. 43:07 I don't I don't think it's I don't think it's advanced. 43:09 I mean writing about it for 25 years. 43:11 I mean it's not it's not so advanced. 43:14 I think people should be doing it and they're not, you know, for sure. 43:19 Yeah. 43:19 No, I'm, I'm, I'm I'm with you on that one. 43:22 I keep scratching my head wondering 43:23 when are they going to make it standard of care. 43:26 Yeah. 43:26 You know, when is it going to be as important as anything else? 43:29 Like because we have the information, like why? 43:33 Why aren't we using it? 43:34 Well, it is our number one killer. 43:36 Still heart disease. 43:39 And you also use other stuff like HDL is it's interesting if the DLLs are small 43:44 or you're making a whole bunch of them 43:47 like over a hundred and, you know, 43:49 and I actually look for toxic metals in that. 43:52 Interesting. 43:52 Because it's a response to toxic metals, the bodies. 43:56 That's the thing, right? 43:57 We don't realize that cholesterol is something that the body is using 44:01 to try and fix a problem. 44:02 I think people have been kind of told, oh, cholesterol is good or bad 44:06 or whatever it is, but your body actually makes cholesterol for a purpose. 44:11 It kind of needs it. 44:13 Yeah. 44:14 That's called your every cell membrane in your body. 44:16 And it's how we make our hormones. So yeah. 44:19 And interesting toxic metal to study. 44:22 Yeah. 44:23 And I'm, I'm by no means here to break the dogma of the lower 44:27 the dogma, the lower the cholesterol the better. 44:30 But there was that huge European study showing that when people had total 44:35 cholesterol of 220 to. Two. 40. 44:36 They lived longer, which is higher, right? Yeah. 44:39 Yeah, yeah. 44:40 It wasn't there a study that also showed that elderly people that had the lowest 44:44 cholesterol had the highest chance of depression and dementia, 44:48 like it actually completely works against the brain. 44:52 Well, I mean, it makes 44:54 the bottom it's not paying off like we need the cholesterol. 44:57 Yeah. 44:57 No, I mean, what we need to do is stop clacking processes without thinking. 45:02 You take the cholesterol out, like, how do we stop meta formation 45:07 and stop the immune system from getting so aggressive and attacking things? 45:13 Right. 45:13 Because, you know, heart disease is an inflammatory process, right? 45:17 Yeah, yeah. 45:17 And I think people don't get it, you know. Yeah. 45:20 And you've been saying it all along. 45:21 It's the elevated chronically elevated cortisol. 45:24 It's the leaky gut keeps coming up. 45:26 You keep talking about the leaky gut and the LPs like it's these are 45:30 things that just keep coming back and they feed each other. 45:34 Yeah, right. 45:35 It's a beautiful dysfunction. 45:37 I mean, look LPs, they've been writing about LPs 45:42 in the clinical rich literature for at least. 45:46 I mean, I know I started talking about a 20 plus years ago, 45:51 at least 20 years. 45:52 I mean, the American Diabetes Association even published a paper that showed 45:56 the higher the lipopolysaccharide in your blood, the more the metabolic 46:02 syndrome characteristics you took on direct correlation 46:06 like pre-diabetes, pre hypertensive 46:09 obesity, mood disorders, hyperlipidemia. 46:12 Right. 46:13 So and but yet nobody is. 46:16 And lipopolysaccharide is associated with the development of dementia. 46:20 It crosses the blood brain barrier. 46:22 It triggers inflammation. 46:24 You make the lectern three galectin three accelerates the inflammation.
Advanced Lipids, Inflammation, and GLP-1s 46:28 And now your neurons are crippled very quick. Right. 46:30 And but but we we don't even tell people what diabetes 46:34 to take a probiotic much less fiber prebiotic. 46:38 How do you really correct your microbiome and get diversity. 46:41 They just are given more meds. 46:43 And it's one of the problems with all these people out there 46:47 shooting up GLP ones. 46:49 And that's the only thing you're doing to fix their glucose dysregulation, as 46:52 they're not appreciating that their gut is broken down by the time they're there. 46:58 Yeah. 46:58 And their access is probably broken down. 47:01 And they have sleeping issues. 47:03 And so they go off the med and everything comes right back. 47:09 Yeah. 47:09 You know, the way I like to talk about GLP ones is it's an opportunity. 47:13 Because when you're on the one you've slowed down the train of damage. 47:18 So this is your invitation to do the work in a world 47:22 where not actively breaking down. 47:24 And if you do that work and you reeducate your palate 47:28 and you build better habits and you adopt better, 47:31 you know, because you've gotten rid of the food noise. 47:33 So maybe now you can make better choices. 47:35 And like, if you can do all those things and get in, 47:39 and it comes down to what you said earlier, and millions of people, 47:42 like so many of us, say nothing's going to replace doing the work right. 47:46 But if you can turn the work 47:47 into the way that you live and your lifestyle, and you can reframe it 47:51 as the way that you take care of yourself, those GLP ones are the silver bullet. 47:56 They really are. 47:57 Like, it's the golden ticket to longevity. 48:00 I call it a lifeline. 48:02 I mean, it's it's a lifeline. It really is. 48:05 Because and what we've done, you know, I mean, obviously I've taught the 48:09 the GLP one certification program and, you know, 48:12 spearheaded data they form for the last five years 48:15 where we really dive into how do you do all those things, diet, exercise. 48:19 And then in the Meira centers at lifetime, 48:23 we're we're showing people losing weight and not losing lean mass 48:28 because because first of all, GLP ones 48:31 do not cause lean mass loss. 48:34 I mean, thank you. 48:35 Multiple studies showing that they actually help you gain 48:38 lean mass if you eat enough protein while you're on them. 48:41 But it's it's the fact of exercise, getting their lifestyle straightened out, 48:47 helping them with a diet, holding them to accountability 48:51 and then moving them through, doing all the things that you just said. 48:56 And then they come out the other side not needing the drug 49:01 because you titrated that drug, that GLP one, only to the amount 49:05 you needed to lose 2 to 3 pounds a week and then you can trade 49:08 off, you've learned your new lifestyle and it and it works. 49:12 And look, I've come a family of obese type two diabetics. 49:17 I have every bad gene snip every. 49:21 I'm serious. It's crazy. 49:23 And I know, like for me to keep myself, 49:27 I mean, I wouldn't be too good if I was getting up on stage at A for 49:30 em and didn't look good for a senior citizen, right? 49:35 Right. I gotta you gotta look the part, right? 49:38 I gotta work, you gotta work, I gotta like, yeah, I'd like to eat more. 49:42 Yeah, I wouldn't mind exercising a little less, but I actually like doing both. 49:47 I like exercise, I adopted, you know, living in a family 49:51 that had a world famous chef. 49:52 I already love good food, but I just had to learn what was the right 49:57 good food. 49:58 I just think that until we get back 50:02 to understanding, it's work, but it's worth it. 50:07 Yeah, yeah, it's it's 50:10 the it's the work of of living the great life. 50:13 It's I think it's a free frame and, 50:16 and getting the life that you, that you want. 50:20 Okay. I don't want to run out of time. 50:21 I want to jump to the peptides because I think 50:23 we need to have a conversation about that. We've been talking for a while. 50:26 I'm jacking. 50:27 I'm just jumping to my peptide section because I want us to dive into that. 50:30 You're too much of a gold mine for this. 50:32 It's the good news is we did the mod, see? But let's start. 50:34 Let's back up a little bit and talk 50:35 about the biggest misconception you see in peptide 50:40 right now the expectations, the sourcing, 50:43 the safety or using them instead of fixing the like, you know, 50:46 let's you get I'm giving you like a two minute rant. 50:51 Like what is making you crazy right now in this peptide conversation 50:54 that's out there, everything you just said. 50:58 Oh, wow. 50:58 No, I mean, look here, here, here, here. 51:00 First of all, it they can be magic bullets, 51:05 but for the metabolic ones, there are no magic bullets like BPC. 51:08 If you have an injury, yeah, it's going to help your injury heal no matter what. 51:13 But the better metabolic shape you're in, the less chronic inflammation 51:19 you're in, the even then, the better the BPC works. 51:23 Yeah, right. 51:24 If there's a biomechanical issue, like I tell people, look, if you've got 51:27 if you've got a like, you've got something going on in the joint. 51:31 And now this is really irritated because of misplacement. 51:35 If you don't correct that imbalance, the BBC is going to help you. 51:38 But then it's like a GLP one. 51:40 It's going to help you while you're using it. 51:42 And then when you stop, yeah, you're going to tour all over this. 51:46 You're back. 51:47 Yeah. It's that whole thing. It's interesting. 51:49 Remember I was at the NBA summit a few years ago 51:51 talking, and I, and I quote the this thought of 51:54 you can never separate biomechanics from biochemistry. 51:58 Right. 51:59 If you're creating pain because of structural issues, 52:02 those signals are the same as if you created them biochemically. 52:06 Right. 52:07 But so anyway, 52:08 the first one is the big misconception thinking of them as magic bullets. 52:13 When I started teaching at Peptide Society, I was big 52:17 on understand what nutrients you need to make that peptide work better. 52:21 Thank you. Yeah. 52:23 Because nobody we all forget that peptides aren't essential, right? 52:29 We make them in our body. 52:30 But like the external use of a peptide is not essential. 52:33 Magnesium is essential. 52:36 You know B6 is essential, right? 52:39 We do. 52:39 You have nutrients on board that are going to help you. 52:43 And it could be any more collagen or any number of things. 52:46 Right. It could be any number of things depending on what you're doing. 52:49 But the bottom line is the more you can think globally, the better. 52:53 And nobody does that. 52:54 The other thing is, is the stacking of peptides. 52:57 Young people that are using peptides, too many, too strong a dose, 53:02 getting them from research houses which don't have to 53:05 they don't need to spend $100,000 in validation 53:10 in order to prove 53:12 they made a safe batch of products. 53:15 So when you made something for human use, you you have all this testing 53:20 you have to do to validate that your method is there. 53:25 And then, you know, there's. 53:27 And then every time you do that method, you have to retest the product. 53:31 And that's another 2025 grand. 53:33 When you when you're a research peptide, you don't have that same mandatory rigor. 53:39 Yeah. So some of you don't. 53:41 Yeah for sure. Exactly. 53:43 And so that to me creates a big a a big problem. 53:48 Secondly there dangerous drugs. 53:51 People shouldn't be buying injectable products out on the internet 53:55 and injecting them in their body without any oversight. 53:59 I mean, people don't realize once you inject something in your body, 54:02 it induces a level of what's called immunogenicity, 54:07 meaning that if that peptides not clean, if it has too much LPs in it 54:11 and no toxin in it because 54:12 and no thoughts and ends up there, you got to filter it out. 54:15 Your immune system is going to go haywire when you inject that. 54:19 And it's potentially life threatening. Yeah. 54:22 And then it's what how much are they doing? 54:25 And then it's, you know, how many how often there's so many variables. 54:31 And it's a lot of people. 54:33 I got to be honest, I never realized so many people 54:37 were into peptide research because they're all over social media. 54:41 There are these people. They must have been their whole lives. 54:43 They were researching on peptides and now they're talking about them. 54:47 And but it's not that it's like the it's like the and look I get it. 54:52 But it's like the but I also don't get it 54:55 because injecting things is different than taking a pill. 55:00 Right. Like the topical Pep. 55:02 They're like peptides are topical oral bio regulators. 55:06 I have less, you know, a little bit less of a threshold on that. 55:09 But the problem is injections, research grade people, you know, pulling it up, 55:16 having a picture of it on Facebook saying, is this the right amount? 55:20 I realize if it's a top one, you could be creating pancreatitis. 55:25 Life threatening things can occur. 55:28 This is not so there. 55:30 That's my two minute rant. 55:32 Yeah, I can't help it. 55:33 I could go on another ten but I won't. 55:35 No, no, let's let's stop because we're going to give people some more stuff. 55:37 But I think that, you know, to put it into context for people, 55:42 if you're not, if you're thinking of getting into this world of, of 55:47 of these really powerful signaling molecules. 55:50 I just want you to think that if you can take micrograms of a compound, 55:56 float it in a 10th of a milliliter of liquid and introduce it into the fat 56:02 in your belly, and instantly, like with oxytocin, within a minute 56:07 you're going to get a head rush, you're going to get hot. 56:11 You're going to feel like, think about how powerful 56:15 these signaling molecules are in your body, 56:17 which is their beauty and the reason why to be respected. 56:22 Right. 56:23 And that's right. 56:24 You know, they're being right now. 56:27 What what I'm afraid of, what I fear right now is they're being diminished, 56:31 like brought down to a cool, fun, almost like a party trick. 56:36 And we need to pull back a little bit. 56:38 Right. We need to. 56:41 And I'm hoping the balance is going to come before something 56:44 bad happens or somebody gets hurt. 56:46 And I mean, look, BPC 157 I don't think we'll ever really kill anybody. 56:50 But at the end of the day, you know, it's it's it's a little bit 56:54 what we talked about earlier is what demands 56:56 are you putting on your system and are you feeding. 56:59 Are you supporting the demands with what it needs 57:01 so that you don't overtax something by accident? 57:03 And maybe let's talk a little bit about you talked about an allergic reaction 57:08 when I, you know, 57:10 you can have an allergic reaction to a peptide even if it's clean. 57:14 And I think the big players there are CJC 1295 57:17 like the growth hormone secreted by CJ 1295, 57:22 even thymus 57:22 and beta four I have found quite 57:25 can be a little more prone to driving reactions in people. 57:30 And I'd love you 57:31 to address that a little bit, because there's this underlying thing 57:34 that says, oh, these are naturally occurring in the body. 57:36 You can't be allergic to them. They're fine. Yeah. 57:38 And the thing is, is 57:39 even if they're naturally occurring in the body, 57:41 once you put them in an injectable form 57:42 and you put them in a needle and you shoot a menu, 57:44 that's not it's a different process of getting it in your body. 57:47 Now your body looks at it potentially as something foreign. 57:52 And so, you know, that's why, you know, if you get a rash from something, 57:57 it's kind of funny. 57:58 When you're a pharmacist, you know, you have to learn these practical things. 58:01 Well, you got a rash from doing that. 58:03 Stop doing that. 58:05 Yeah, it's real simple. 58:08 You know, that's my clinical pharmacy background, right? 58:12 It hurts when you go like that. 58:13 Oh, don't go like that. 58:15 And then we'll fix why it hurts when you go like that. 58:18 Right. 58:18 But but I think that's the biggest issue is people ignore those signs. 58:22 And that's a problem. 58:24 And it is a legitimate thing on the Cogs, especially if I'm on CJC. 58:30 If you notice yourself getting a wheel or a hive, you have to stop 58:34 because the next time it could be your airway closes. 58:37 I mean, it's that simple. 58:39 And so I think that's where that lack of respect 58:42 and I do agree with you, it's people think they're like their dietary supplements. 58:46 It's like the next level of a dietary supplement. 58:48 These are powerful drugs. 58:52 They're just they're drugs 58:55 that offer a bigger upside and a lot less downside. 58:59 And that's why a lot of peptides are now in healthcare. 59:04 And that's why insulin, the first peptide 59:07 in healthcare, has created so much value. 59:11 They because our body have recognizes them. 59:14 There's less of like a foreign material just blocking something occurring. 59:19 Right. Yeah. 59:20 So that part is you know, really what I think people need to understand. 59:25 And, you know, and like in general, I have to be honest, 59:29 I haven't seen a lot of people like when we testified before 59:33 FDA gushed about a year ago. 59:36 At this point, I collected over a million scripts 59:40 from nine pharmacies without a significant adverse event, 59:46 meaning, you know, somebody hospitalized got their die. 59:50 Not a single one. 59:52 Did they have a side effect? 59:55 Yeah. Well, you know, you're drinking water. 59:57 You can have a side effect. Yeah. 59:59 You know, each of many potato chips. 1:00:01 I mean, it's always possible that you get that. 1:00:05 But there wasn't there wasn't any big adverse events that were reported. 1:00:10 And that's what I think the beauty of peptides are. 1:00:12 But I do think in general it once, not just once they're injected. 1:00:18 You got to do it under supervision. 1:00:20 Like somebody needs to know what they're doing, telling you how to do them. 1:00:25 So there's watching to see 1:00:27 is this accomplishing our goal when you're taking this. 1:00:29 Yeah. Is this going in the right direction. 1:00:33 Yeah. 1:00:33 Is it the right thing right now for you? 1:00:35 100%. 1:00:36 VPC miss, there were a couple we talked about before we started recording that. 1:00:41 I just I'd like to blow them up right here, right now, please. 1:00:44 And thank you. Cool. 1:00:45 Because I'm tired of hearing people talking about them, 1:00:51 and I'm not a pharmacist, 1:00:52 so you've got more gravitas than me, so they'll listen to you. 1:00:55 So the first one, and as I think it's a nuance 1:00:59 that somehow people have misinterpreted in the literature. 1:01:02 BPC 157 one of the things, one of the many beautiful actions 1:01:07 that it performs in the body. 1:01:08 I've always learned, is that it upregulates the expression of growth 1:01:12 hormone receptors, which is part of how it helps with healing to soft tissue.
Peptide Safety, Misconceptions, and BPC-157 1:01:19 Maybe somewhere along the line, somebody skipped a few words 1:01:22 in the sentence and decided that BPC 157 increases the release of growth hormone. 1:01:27 Can we please just put that baby down to rest 1:01:30 by at a beautiful bouquet of flowers and by forever? 1:01:33 I think that's why they aren't using it in any professional sports 1:01:37 is because of that statement right there. 1:01:40 Because if it if it increases growth hormone release, that's going to ban it. 1:01:45 But if the receptors are just functioning better, meaning that my body 1:01:52 is just accepting what I'm naturally releasing better, what's the problem. 1:01:57 Right. 1:01:57 And so yes, it upregulates 1:02:00 growth hormone receptors, but it's not a secreted Gog like Surma. 1:02:06 Ellen Ellen CJC 1295 formerly Tessa Maryland. 1:02:11 Right. Yeah. 1:02:12 So all of those you know yeah they caused that but not VPC. 1:02:18 And it's such a shame you know, because particularly in professional sports 1:02:21 where BPC has neuroprotective effects, it can help Heelys. 1:02:26 It like it's so beneficial for those guys. 1:02:28 It helps with healing the gut which you know, an extreme athlete 1:02:32 is going to have a leaky gut just because of all the stress that they're under. 1:02:35 It's you know, I don't know, I hope that someday somebody comes to their senses 1:02:39 and allows it because it makes me sad. 1:02:42 These guys and some of them get suspended because they they get suspended 1:02:46 for using it. 1:02:47 You I mean, I've seen people heal. 1:02:51 I mean, my sons Liz Frank injury I mean a big foot injury 1:02:56 and he healed and like 40% of the normal time. 1:03:02 Oh yeah I mean it was amazing. 1:03:04 And and they he and you heal better. 1:03:08 Like, the tissues heal better and they protect you if you're getting 1:03:13 cortisone shots so that your college and and connective tissue doesn't dry out. 1:03:18 There's so many benefits to it. 1:03:20 It would help so many athletes. 1:03:22 And you know I, I wish that that one was different. 1:03:26 But you know, I have people call me all the time and ask, hey, 1:03:29 can I use, you know, say work with, you know, a lot of forces 1:03:33 and professional teams and like, no, can't do it. 1:03:37 And I'm telling you, you can't do it. 1:03:40 I'm not telling you wink, wink, you can do it. 1:03:43 But no, no, no, don't. 1:03:44 I'm really telling you don't because they will pick it up on you people 1:03:48 they went that they cannot test for. 1:03:51 Well how do they look for. 1:03:53 They left like tablets. 1:03:55 So I don't think the other population that benefits a lot from BPC. 1:03:59 I mean everybody does in, in the right at the right 1:04:02 time is the is our elderly population. 1:04:05 Oh, without a doubt. 1:04:07 Like my mom and dad, I have on occasion helped them through some stuff. 1:04:12 And and they're medical people 1:04:15 kind of scratch their hats and wonder how did that happen? 1:04:18 Right. 1:04:20 But it works like, I mean, you know, I mean, the beauty is, is 1:04:24 I think in health care now, there is at least that thought of, 1:04:28 we don't know what you're doing, but you're better. 1:04:30 So keep doing it right. That kind of thing. 1:04:33 I like that instead of kind of that strict scolding 1:04:37 that used to be the case of, you know, there's no evidence. 1:04:40 I mean, we, you know, we've written an international peptide society. 1:04:44 It kind of spirited my staff and I 100 monographs 1:04:48 with all the full text studies on peptides. 1:04:50 Wow. And rated by the level of evidence thousands of pages we've done. 1:04:55 So the evidence is out there. 1:04:57 The other thing on BPC that everybody talks about 1:05:00 is all it can induce cancer. 1:05:02 It's going to increase cancer formation. 1:05:06 Number two, it doesn't it does not. 1:05:08 It's called a it's selective angiogenesis meaning it's 1:05:13 selective in the way it promotes blood vascular. 1:05:17 Pretty like it's going to help get blood flow to your muscles and tissues. 1:05:21 But it doesn't feed organ. 1:05:24 It doesn't feel like a tumor. 1:05:25 So and there's papers on it. 1:05:27 It's over and over again. 1:05:29 But there's this thing of, oh, this peptide 1:05:32 causes, you know, can feed or cause cancer. 1:05:36 You had mentioned when we were chatting before 1:05:37 TB for, you know, TB for thymus and beta for, 1:05:41 I mean, it's there around the tumor to try to fight the tumor. 1:05:45 Yeah, exactly. 1:05:46 But you know, it's I'm shocked at this, at how these words 1:05:50 sometimes come out of medical people's mouths like this. 1:05:54 Talk about not understanding a pathway. Right. 1:05:56 It's really it's disappointing. 1:05:59 And you wonder sometimes or people just trying to get eyeballs because it's the, 1:06:04 you know, the literature is very it's pretty clear 1:06:07 there is quite a lot of evidence that, yes, that's why you're Achilles. 1:06:11 That gets no blood flow, will actually heals. 1:06:15 Exactly. Right. 1:06:17 Like this is why it will be to the muscle and connective tissue in the bone. 1:06:22 Right. 1:06:22 So I know and that's under that injury. Right. 1:06:25 And and yeah. 1:06:26 And I think why I've enjoyed teaching it a forum for the last 25 years. 1:06:31 And you know and being a co-chair is. 1:06:34 I have a lot of docs come there and when the light bulb goes off. 1:06:39 It's like 1:06:39 that's the most rewarding thing when I have a practitioner come 1:06:42 and they say, hey, you know, you change the way I practice and I love 1:06:47 doing medicine again because now they have solutions 1:06:50 and people come back and say they feel better. 1:06:52 They're not just managing them with a drug. It's like hey. 1:06:54 And once again we have two health care systems. 1:06:57 How do we keep people? 1:06:58 Well, and once you're not well, we got to manage it. 1:07:01 Still, we still got to love you. Yeah. 1:07:04 We can't, you know, it's like this. 1:07:05 It's this yo sick care system. Horrible. 1:07:08 Know when people are sick. 1:07:10 I know my family, my brother, my father. 1:07:13 Both their lives saved by modern medicine. 1:07:15 Yeah. Listen. Yeah, right. 1:07:18 But the problem is we don't do enough on how to keep people. 1:07:22 Well, it's that simple. 100%. 1:07:25 Do you want to talk a little bit about different modes of administration for BPC? 1:07:29 Because that's another thing that people incessantly. 1:07:32 And I'll tell you a tiny story first and then I'm going to let you roll. 1:07:35 Sure. 1:07:36 So I, I decided my mom and dad, you know, they're in their late 80s. 1:07:40 It was time for them to do a gut healing thing. 1:07:43 And so I have a supplement manufacturer I really like. 1:07:48 I gave them it's a, it's a stack with built with BPC 1:07:51 and a bunch of other peptides that are really focused on the gut, 1:07:54 so sent it to them. 1:07:56 My mother, of course, doesn't listen to everything I say. 1:07:58 So she doubled the dose and after two and a half three weeks, 1:08:01 I get a call from her saying, we need more of that stuff. 1:08:04 I'm like, yeah, like, hey, which stuff are we talking about? 1:08:08 Because I send this stuff. Spent a lot of stuff. 1:08:10 Yeah. Which one, which one and why? 1:08:13 And she said, well, you know, those pills that you get. 1:08:16 And so she, I figure out it's the BPC stack. 1:08:19 And she said, well, and she had, she had just really injured her shoulder. 1:08:23 So she's 87 years old not healing very you know, she's okay. 1:08:27 I mean she's great, but she goes, well, 1:08:29 my shoulder stopped hurting and your father's back stopped hurting. 1:08:33 Yeah. 1:08:33 And and you know, all our Instagram 1:08:36 warriors out there saying or VPC doesn't work on anything. 1:08:40 Anything is one pan. 1:08:41 And then the other camp says it'll never touch a physical 1:08:45 like musculoskeletal issue. 1:08:47 So yes, the injectable and maybe transdermal might be better, 1:08:52 but I'd love you to speak a little bit to some of the different modes 1:08:55 of administration of BPC 157 and yes, it can be used orally. 1:09:00 Yes, it's going to help. 1:09:01 It's kind of going to go where it needs to go. Yeah. 1:09:03 I mean, yeah, I mean BPC absolutely. 1:09:06 People have used it orally and have seen benefit from it. 1:09:09 And you know, there's different ways that you can administer that. 1:09:12 You can do it as a capsule. 1:09:13 We were involved in developing a liposomal solid state tablet that, 1:09:17 you know, that doesn't go through first pass effect. 1:09:20 It absorbs into lymphatics. 1:09:22 And so it was a that actual 1:09:25 delivery system was worldwide patent pending on all drugs, 1:09:29 all nutrients for small molecules and peptides. 1:09:32 And so we started it. 1:09:35 Yeah. You can get you can get it. It's pretty cool. 1:09:37 But so the point being is then there's yeah, you can use it topically. 1:09:41 But people thinking the BBC orally isn't going to help your gut. 1:09:45 It's kind of funny because when you swallow it, it goes through your gut. 1:09:48 And BPC actually stimulates the mucosal 1:09:53 to produce more mucus and repair. 1:09:55 And so you take it that way. 1:09:57 And guess what happens? 1:09:59 70% of your inflammatory response is coming from your gut anyway. 1:10:02 So as you calm down the inflammation signaling in the gut, you help 1:10:06 global signaling. 1:10:07 And the fact is you're sending those signals. 1:10:11 Once again, our body is a system of systems. 1:10:14 You're sending those signals to the Myakka, 1:10:17 which is the muscle network, to say, hey, 1:10:22 I don't hurt so much now. 1:10:24 Right? So yeah, it's totally, you know, 1:10:26 people would say, oh, BBC is an oral doesn't work. 1:10:30 You know, that's once again, bro bro. 1:10:37 And then but then of course, under the supervision of the right person, 1:10:41 injectable does tend to be the most effective and efficient, 1:10:44 especially on a two day injuries. 1:10:45 I mean, honestly, I've seen enough of the light 1:10:50 delivery that I think on chronic injury it could catch you up pretty quickly. 1:10:54 But on the acute stuff, of course, an injection 1:10:58 is the way to go and hopefully we're going to get that back. 1:11:01 There's a lot of rumblings that we're going to get some peptides back. 1:11:04 I'm sure hoping that happens so that, you know, it's easier for people to get them. 1:11:08 And if we can get them in compounding pharmacy and that stops 1:11:14 research pharmacy, then by default scripts get written and it's under supervision. 1:11:19 That'd be my dream. 1:11:21 Yeah. Okay. 1:11:22 I'm that's not a bad dream. 1:11:24 I'm okay. 1:11:25 So another question. What are your red flags? 1:11:28 That someone is using peptides to override recovery signals 1:11:31 and dig a deeper hole that happened ever did? 1:11:35 Oh, yeah. 1:11:37 Yeah. 1:11:37 I mean, I think the red flags to me are they're still sore too long. 1:11:42 They're doms. So they get like that. 1:11:44 They're delayed on onset. Muscle soreness is off. 1:11:47 Their reaction times are off. 1:11:49 Their heart rate isn't you know, is going up. 1:11:53 Still two minute heart rate recovery is not good. 1:11:56 I look for a lot of those autonomic things like hey, where's your you know, 1:12:00 what's your two minute heart rate recovery? 1:12:01 Where's your resting heart rate. 1:12:03 What's your heart rate variability like. Right. 1:12:05 How saw are you. 1:12:07 I mean all those things kind of tell you, especially if people are taking it 1:12:10 that they're trying to kind of mask recovery. 1:12:13 Yeah. 1:12:14 You know it's still going to it's still going to show because it doesn't 1:12:18 necessarily reset the autonomic nervous system. 1:12:22 Yeah. No. 1:12:23 Are there labs that you would run before. 1:12:25 Do you think people should run 1:12:26 or should be run before people use peptides like is there 1:12:30 are there any lab markers that I mean, I mean definitely on the metabolic side 1:12:35 with the GLP, once the blood sugar, the even inflammation, all of that stuff. 1:12:40 But with any like, do you think IgG4 one is a valid marker before someone's 1:12:45 going to throw, even though it's not an exact analog to growth hormone? 1:12:51 Do you think that there's any validity to looking at IGF 1:12:53 one before somebody uses a growth hormone security dog? 1:12:56 Because I get that question a lot, right? 1:12:58 Especially from people with teenagers. 1:13:00 I'm like, they don't need growth like they're making it, but do you see that? 1:13:05 And and even in an older person, their idea of one might be great. 1:13:09 Yeah, right. 1:13:10 I don't you know, the problem is, is I found it such a friable number 1:13:14 I you're offline our and it can be really different you know. 1:13:19 So I think like the and a lot of times we don't realize research 1:13:23 labs can be different than what's available commercially. 1:13:27 So for example lipopolysaccharide there's no serum 1:13:30 available commercially if you only get an antibody test for it. 1:13:34 And that's not the same thing as what all the literature said. 1:13:36 So they're different assets. 1:13:39 Yeah. Yeah. 1:13:40 So I'm not as big like I let's put it this way. 1:13:45 Once somebody's got their insulin resistant and their iPhones going high 1:13:49 because they're getting their pre cancer, I start getting worried about that. 1:13:53 So I'll measure them. 1:13:55 And people that are insulin resistant and want to add secreted gods. 1:14:01 It's like well let's see where your IGF one is at right now. 1:14:04 You're already through the roof because we know that that goes up 1:14:08 when you start creating the Warburg effect or more cellular 1:14:12 kind of aerobic glycolysis, cancer behavior chemistry. 1:14:16 But I mean other than that I don't worry about it as much. 1:14:20 I'll look at things like, you know, if we're looking at, you know, using, 1:14:24 you know, peptides for healing, metalloproteinase nine, 1:14:27 metalloproteinase three, looking at metallic protein ACS, 1:14:31 which are the connective tissues, inflammatory markers. 1:14:35 You know, I'll look at those if I'm using something like thymus and alpha one. 1:14:40 You know we teach that you know you can look at neutrophil lymphocyte ratios. 1:14:46 You can, you know, kind of start to characterize what are we looking for. 1:14:51 What are we looking for. 1:14:52 Their well, 1:14:53 you know, your neutral site ratio is like how hard are you being pushed. 1:14:57 Right. So if you're a neutrophils are real high. 1:14:59 You're in a chronic state of inflammation. 1:15:02 The trail low. 1:15:03 It means you've lost your resiliency to respond. 1:15:06 And so you know you kind of want to be in the middle. 1:15:10 And and just like that DHEA ratio right. 1:15:14 And then you know you could certainly look at white blood 1:15:17 cell counts and see where they're at. 1:15:20 You could look at 1:15:22 if you want to get really elegant cytokine panels, advanced cytokine panels. 1:15:27 But most people just honestly I don't do a lot of it anymore. 1:15:31 I mean, I look at regular labs 1:15:33 and then if I need to check metals or check for bio toxins, 1:15:36 maybe things that are environmental burden to the body I check for. 1:15:40 But a lot of times, I mean, I'll do a galectin three because it it's 1:15:44 highly correlated to increasing diabetes and dementia risk. 1:15:49 You know, 1:15:49 look at things like a depicting because it correlates mitochondrial output. 1:15:54 But, you know, I think for a lot of people, 1:15:57 you know, the first step is, is, well, what am I using this peptide for? 1:16:01 Oh, I'm healing an inflammation. 1:16:03 Well, let's look at inflammatory markers in your body. 1:16:05 Where's your CRP at. 1:16:07 Where you know, where is your nine out. 1:16:09 You know, where is your call to at. 1:16:12 You know like you can get markers for inflammation in tissue 1:16:16 let's say non immune. 1:16:18 Like it's not an A and A or rheumatoid factor 1:16:21 or a C3 A or C4 a, I hurt myself. 1:16:25 It's not been getting better. 1:16:26 What could I measure. Right. 1:16:28 And so I think you do that. 1:16:29 And then metabolically look the scale works good 1:16:33 if you're trying to lean yourself out measure you know, get a body comp. 1:16:36 Are you are you improving lean mass I want to take 1:16:39 you know, I want to take screening guys improve my lean mass okay. 1:16:42 Is it working? 1:16:44 Did you measure it? Measure measure it. 1:16:47 You know the measure. So because here's the thing. 1:16:49 People spend a lot of money on these things. 1:16:52 Yeah. 1:16:52 Like, you know, I mean, I it's like I don't you want to know if it's working? 1:16:57 Yeah. No, for sure. It's a lot of money. 1:17:00 So I want to spend a minute on the liposomal chewable peptide 1:17:03 angle a little bit. I want to talk about that a little bit. 1:17:05 You've mentioned it a couple of times. 1:17:07 And then we're just going to go into we're going to finish up. 1:17:10 So you you. 1:17:11 So Metabolic elite has a patented oral liposomal tablet. 1:17:15 Do you want to talk to people a little bit about why is it different.
Oral Liposomal Peptides and Delivery Innovation 1:17:18 How is it bypassing. 1:17:19 Is it is it a Google tablet that basically 1:17:23 so it's chewable. 1:17:24 So it is you are swallowing it and yet. 1:17:26 So fill us in. 1:17:27 Yeah. Yeah. 1:17:28 So it was funny 1:17:29 I first found it this technology because I was looking for a way to deliver 1:17:34 Gen R3 because I had developed it as a nasal spray known as synapse. 1:17:38 And and you know, which is great 1:17:40 for decreasing microglial activation, but you couldn't take it orally. 1:17:44 There's just you had to take too much of it. 1:17:46 And this stuff was super expensive. 1:17:49 So I found this pharmaceutical scientist that had developed this. 1:17:52 He had patents on it. 1:17:53 And what it does is it he patented it for all compounds 1:17:57 because it delivered difficult to difficult to deliver compounds. 1:18:02 Either class for compound scenes didn't absorb or taking small molecules 1:18:08 and be able to get them 1:18:09 into the micelles in the limb and not go into first pass effect. 1:18:13 And that's what you know what? 1:18:16 So it's a multi-layered and I did not develop it. 1:18:19 I'm just saying the scientist developed it. 1:18:21 I looked at application 1:18:23 and I looked at it and went, wow, that could be really interesting. 1:18:28 So I developed it and with them added that synapse. 1:18:31 And as the very first thing we did, 1:18:32 because it's a small molecule, difficult to absorb. 1:18:36 People loved it. Their cognition was better. 1:18:38 They just like that, almost like the nasal spray. 1:18:41 Nasal spray. Once again you hit your head. 1:18:44 You've got, you know, you know, your early dementia. 1:18:47 You probably want to use the is great. 1:18:48 Otherwise, the tablet ended up working just as well. 1:18:51 And we just did our first person in a trial where we we did it 1:18:57 and we saw 40% improvement 1:18:59 in cognitive processing and wow two doses. 1:19:03 Yeah. So it's pretty cool. 1:19:05 So you're kidding. 1:19:06 Then we started playing with it and adding things like semaglutide 1:19:11 with the compounding pharmacy using Surma Ellen. 1:19:15 We did testosterone where we could do physiologic doses 1:19:19 like five milligrams tabs of testosterone as a life is all tablet 1:19:23 and and you chew it and you're just matching the circadian rhythms. 1:19:28 So you chew it in the morning and you chew a smaller dose in the afternoon, 1:19:32 and you're matching your natural circadian rhythm, and it clears out at night. 1:19:37 That's one of my big believer in biomedical hormones. 1:19:40 But there are people that are sensitive to just like having, you know, nonstop 1:19:47 signaling because of that hormone being deposited via injection. 1:19:51 And once again, there's room for all these types of delivery systems. 1:19:57 Pellets work because people want convenience. 1:20:00 I like this because there's people that don't tolerate pellet. 1:20:04 Sometimes they get acne from that kind of stuff. 1:20:06 And we you can do this. 1:20:09 And our first person that we actually started doing every half hour 1:20:13 but draws 1100, 700, 1:20:17 500, 400, 700 because we gave a smaller dose second one. 1:20:23 And so we're following these folks now. 1:20:26 And it's turning out there. 1:20:28 Their liver enzymes don't go up. 1:20:29 They don't build more iron. 1:20:31 They're you know, they're hemoglobin doesn't go crazy 1:20:34 because it's because it's following your diurnal pattern. 1:20:37 And that's one of the things of the last ten years is trying to figure out 1:20:42 what's why. 1:20:42 Apatow an so amazing it resets as a peptide your diurnal pattern. 1:20:47 So we started playing with using this, 1:20:52 you know, liposomal technology to deliver peptides. 1:20:57 You know you know and and we're finding it enhance their effectiveness. 1:21:01 You know. 1:21:02 So it's really an interesting work that he did. 1:21:05 They developed it for oncology drugs and for pain meds 1:21:08 because you could take less of it and reduce the risk of adverse event. 1:21:13 Yeah. 1:21:14 So the last question on this is in the white paper you contrast 1:21:18 liquid liposomal versus versus the tablet. 1:21:23 And it has to do with stability right. 1:21:25 And particle size. 1:21:25 Do you want to just address that a little bit. 1:21:28 There's there's 1:21:28 liquid liposomes all over the place which I mean we're not going to try them. 1:21:32 But there's if there's a distinction there that's to be made I think. 1:21:35 Yeah. Yeah. 1:21:36 Yeah. 1:21:36 There is I mean so we know the particle size of this liposomal tablet. 1:21:40 We've done electron microscopy and for copy on and against a variety of 1:21:44 compounds, it maintains the particle size at under 100 nanometers, 1:21:49 which is the particle size you need to get across your cell membrane. 1:21:52 And in many cases they're like 57 nanometers super small. 1:21:57 The problem with liquid liposomes and this is nothing against liquid liposomes. 1:22:03 But you hear the term liposome and you think everything's 1:22:06 it's all one thing and they're not. 1:22:07 Yeah. Liquids tend to agglomerate they. 1:22:11 So when you make a life of zone they use these electrical charges to separate stuff 1:22:16 separates the particle and it disperses it. 1:22:19 Well, the problem is, is that the laws of attraction, 1:22:23 the particles start coming back over time, and then you start building 1:22:27 bigger and bigger compounds. 1:22:29 And all of a sudden, after you've made it nine months later, 1:22:32 the product is too big to absorb. 1:22:35 It's a blob. 1:22:36 And yeah, it's a big bob and you can't absorb it. 1:22:39 It's like 3000 nanometers instead of 50. 1:22:41 And so, you know, that's the 1:22:43 which is the kind of same story is the tennis net, but in a positive way. 1:22:47 And this situation, 1:22:49 you want small nanometers to absorb things into the cell membrane. 1:22:52 If they're real big, they can't get in. 1:22:55 And that's a real yeah. 1:22:58 It's been a great innovation. 1:23:00 It's continuing to evolve. 1:23:01 It's pretty fascinating. 1:23:03 We're working on a multi weight lipid 1:23:06 that you that you can put a compound in. 1:23:10 Rub it on your skin and it pulls all the way down 1:23:14 into your tissue to get into your bloodstream too. 1:23:17 So it's pretty. 1:23:18 It's been it's part of one of my I guess my big passions 1:23:22 is I love technology and software analytics and all that. 1:23:26 But then I love a receptor. 1:23:30 Well, circle your full circle okay. 1:23:33 Last few quick questions here. But let's make these. 1:23:36 We're going to go and fire for the end here. 1:23:38 If you zoom out five years what will be the best. 1:23:40 What will the best longevity clinics be doing that today's 1:23:44 clinics are not providing more adherence and guidance 1:23:48 so that people stay on their program and actually change their behaviors more, 1:23:53 instead of just handing them programs and expecting them to do it. 1:23:57 Okay, what's the next meta inflammation blind spot? 1:24:01 You think the public will realize too late unless we change the narrative 1:24:04 right now? 1:24:04 Wow. Honestly, I think there's something to electromagnetic pollution. 1:24:09 You know, I've been watching it for a long time. 1:24:12 Actually, my one mentor in Germany was big on it. 1:24:16 So I think that you kind of have to watch, you know, and I'm not saying 1:24:20 go extreme because we're all getting hit with 5G and whatever. 1:24:23 When we open up, we see all the networks. 1:24:25 But you know, having your phone next to your head, you know, always having 1:24:29 these kind of things on 24 hours a day, like all that kind of stuff. 1:24:33 I think, you know, you look at how many people 1:24:35 just have their phone with them all the time 1:24:37 and have other kind of devices with them all the time.
Longevity Clinic Trends and Closing Resources 1:24:40 I know there's an awareness that's floating up in the professional sector. 1:24:44 I don't think the public's anywhere near aware on that. 1:24:48 Yeah. Got it. 1:24:50 All right. One biomarker you think is underrated. 1:24:52 Just one mean platelet volume. 1:24:54 One biomarker you think is overhyped. 1:24:56 Cholesterol. 1:24:56 One daily habit that gives the best ROI for inflammation. 1:25:00 Learn that life is about joy I love it. 1:25:04 The most common mistake high performers make with recovery 1:25:07 they don't do what they need to recover. 1:25:09 Not enough sleep. 1:25:10 They don't eat. 1:25:11 Not asleep. 1:25:13 Yep. The question you wish every patient asked in the first ten minutes, 1:25:17 when they sit down in front of their medical professional wish, 1:25:20 they asked, are you going to really pay attention to what I'm going to tell you? 1:25:25 Thank you. 1:25:26 This has been a great conversation. 1:25:28 We've covered a lot of ground. 1:25:29 Thank you. Yeah. Let's go. 1:25:31 I feel was fine. 1:25:33 Thank you so much. I want to do it again. 1:25:35 You have to invite me back. 1:25:37 Oh, yeah. 1:25:37 No, we're doing a part two 100% that you can count on it. 1:25:41 So in the meantime, where can people find you? 1:25:44 Where are there any resources you'd like to share with people and all the things? 1:25:50 And yeah, it's a book on peptides. 1:25:52 Peptide Handbook, available on Amazon. 1:25:55 Written two additions to that. 1:25:57 Obviously the metabolic codebook still out there and really good. 1:26:00 And it actually talks about all this stuff. 1:26:01 But the new one will be out this year. 1:26:03 Handbook on Your Blood Never Lies, a book that how to read a lab test for help. 1:26:08 Yeah, right. 1:26:09 That big a lot of people, a lot of providers use that. 1:26:12 Actually, I wrote it for consumers and then Jim. 1:26:14 Com and then the real Jim Lovell on Instagram has got so many posts 1:26:19 where I'm going over stuff, I didn't even know how to do it. 1:26:23 My son's got me out on all that stuff. 1:26:25 I mean, I didn't even realize anything about any of that stuff. 1:26:28 So he's. 1:26:29 Yeah, he's got me out there now. 1:26:31 And, you know, fortunately, few people want to listen anyway, so it's good. 1:26:35 Okay. 1:26:36 Well, I'm going to ask one more question, one more thing, 1:26:38 because people are going to ask for the Life is On tablet of BPC 1:26:41 or whatever else that is by prescription, through a compounding pharmacy 1:26:45 and a physician. 1:26:45 Or is that something, an OTC product? 1:26:48 Yeah, I mean it really right now you can get it 1:26:52 through a vaccine, through a physician. 1:26:55 I mean, the BBC orals is still kind of in a gray area. 1:26:59 So metabolic Elite is still making it. 1:27:01 But as soon as we get clear guidance, they may not be making it anymore. 1:27:06 That's a company my son runs. 1:27:07 I mean, it's just it isn't. 1:27:09 Nobody's doing anything about the capsules. 1:27:11 I mean, so I just I don't know what's going to happen from that. 1:27:13 But you get you can get it there for now. 1:27:16 Yeah. For metabolic elite. Com. 1:27:18 Right. Amazing. Thank you. Yep. 1:27:22 All right. Sorry. 1:27:23 Thank you so much. 1:27:25 It's been great. 1:27:26 And I can't wait for part two. 1:27:28 Yeah. Let's do it.
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