Full Transcript Introduction to the Lyme and Alzheimeru2019s case study 0:00 Hello everyone. 0:01 My name is Doctor Richard Horowitz and I am the co-host of this year's 0:03 2026 Doctor Talks Healing Lyme Summit. 0:07 The topic of this year's Lyme Summit is the Neuroinflammation Brain Protection 0:11 Summit, and I'm sharing with you some really exciting information for me. 0:16 Maybe, honestly, one of the most exciting things I've shared in decades 0:20 because of the implications from this case study that we recently 0:24 submitted to the Journal of Alzheimer's Disease Case Studies, 0:27 where we reverse Alzheimer's markers in a patient with chronic Lyme disease 0:31 using the short term oral DAPs on combination therapy. 0:35 So this study, it was printed it out just so I can go through the study 0:39 a little bit with you and explain to you what the study shows. 0:43 But it's very, very exciting information because many of you know 0:47 that one of the worst side effects that you have from 0:50 Lyme disease is your memory and concentration. 0:53 People go have word finding problems. 0:56 They walk into rooms and they can't remember why they walked in. 0:59 There's a lot of problems with remembering numbers, right? 1:01 Phone numbers walking into rooms again. 1:03 So it's it's a question of like how do we improve cognition. 1:07 How do we not only improve fatigue and joint pain and muscle pain, 1:11 but especially cognition? 1:12 Because the medical literature tells us 1:16 that up to approximately one quarter of the Alzheimer's cases 1:19 that are out there, I'll share with you some of these statistics shortly. 1:23 Some of these statistics show that up to one quarter of these 1:26 Alzheimer's cases may actually be due to Borrelia burgdorferi, 1:29 an associated spark that's like identical to spark in the mouth. 1:33 So it's really, really important that we understand 1:36 not just, hey, I have chronic Lyme disease. 1:39 My memory's not working. 1:41 But is there a danger going forward where 1:44 we may develop dementia type symptoms later in life? 1:47 Now, I want to be clear. 1:49 This is a case study. 1:50 One study that we presented that we submitted to the Journal of Alzheimer's 1:54 Disease Case Studies, 1:55 in a patient who met all the criteria for chronic Lyme disease 1:59 as which I explained to you, and we cannot generalize 2:03 from this one case study and say that everyone's 2:06 going to be at risk of dementia if you have Lyme. 2:08 That is not what I'm saying. 2:09 But what I am saying is I'm going to show you a literature review
Why Lyme may affect cognition and dementia risk 2:14 and go through this with you to explain to you why I think it's important. 2:17 We need more research in this area. 2:20 Why? If you're a patient who has chronic Lyme disease 2:23 with post-treatment Lyme disease syndrome, you ask your doctor 2:26 to check for these new Alzheimer's markers that are now available through your lab. 2:30 For the specific markers we're talking about 2:33 is Peter one £0.81 Tau 217 2:38 neuro filament light beta amyloid 4240 ratios. 2:42 And if you suspect that you may have a genetic predisposition for Alzheimer's, 2:47 you can also check your ApoE 2:49 markers, your genetic markers, 2:51 to see if you have a higher risk, which is the apo e4 four. 2:55 So in this case study that we submitted improving biomarkers 3:00 in a patient with chronic Lyme disease LDS the background is is that several years 3:05 ago, Doctor Eva Ciampi reported in the medical literature with colleagues 3:10 that Borrelia had been found to co localize with Alzheimer's 3:14 markers in brain tissues with biofilm, amyloid and p tau. 3:19 Now, the reason this is important is because the Alzheimer's rates 3:23 are going up. 3:23 It's supposed to double in the next 20 to 30 years. 3:26 And it's a big problem because years ago, the government had told us 3:30 that about 46 million Americans had preclinical dementia, 3:34 and there are no clear cures for Alzheimer's disease. 3:37 Right now, people are looking at how do we take out 3:40 beta amyloid by using monoclonal antibodies. 3:43 But, you know, the standard drugs that they use for Alzheimer's, 3:47 like using memantine, namenda or acetylcholinesterase inhibitors 3:51 like aricept, they may help a bit with the memory concentration, 3:55 but they don't stop the process, 3:56 which goes forward over time, where people eventually get worse and worse. 4:00 Memory, concentration. 4:01 As time goes on. 4:02 These drugs help with symptoms, 4:04 but they don't change the pathological process. 4:06 So knowing that there have been researchers and especially Judith MacLeod, 4:11 who has published multiple articles, which we'll talk about in a minute 4:15 on how Lyme disease has been found to be associated with Alzheimer's. 4:18 And this study was very important, 4:20 published by Iva shopping in a group several years ago that when they looked 4:24 at autopsy tissues of both Alzheimer's and Parkinson's disease, 4:28 they found that amyloid beta and biofilm was associated with Alzheimer's. 4:32 Now, what's interesting to me about this is we had proven, 4:35 based on culture studies that I did with Iva Shopee's group years ago, 4:40 that daps on combination therapy hits these biofilm persist, 4:43 or forms of Lyme disease, but we never had any evidence 4:47 that we could reverse any of these Alzheimer's markers. 4:50 And shortly before I stopped one on one clinical practice write, I 4:54 now am primarily doing 4:55 consultation medicine like Neil, Nathan and certain other doctors. 4:59 And for those of you interested,
Background research linking Borrelia to Alzheimeru2019s markers 5:00 you could learn more about the consultation service. 5:02 The guy on my website can get better.com and looking up to the consult service. 5:08 But the reason we became interested in 5:10 this is because these markers only recently became available. 5:13 So I started checking some of our line patients 5:17 who had either not yet done some combination therapy 5:20 or who were partially through the option, but had not completed the therapy. 5:24 They either didn't get through the full nine weeks of double dose 5:27 option combination therapy, or they had Bartonella. 5:30 They had not finished all the pulses for Bartonella. 5:32 They had not completely cleared mold toxins in other words, 5:36 Alzheimer's disease. 5:37 And we published this, by the way, in this paper, 5:40 all 16 factors 5:42 that I have shown to be associated with chronic Lyme and also we published 5:46 this in long Covid back in the journal microorganisms back in 2024. 5:52 We're now publishing that all 16 factors 5:55 are also associated with Alzheimer's disease. 5:58 Now, this is really important because this means that you don't 6:01 just have to accept a diagnosis. 6:02 When a doctor tells you they think you have a demented illness, 6:06 you now have options. 6:07 By looking at these 16 factors and figuring out 6:11 where is the inflammation in the brain coming from? 6:14 Is it coming from bacteria like Lyme disease? 6:17 Bergdorf. Right. 6:18 Bartonella, chlamydia pneumonia, by the way, has been associated 6:21 with Alzheimer's disease. 6:22 So have viruses like herpes virus one, herpes virus two, 6:26 halves seven and eight, and fungal infections have been associated. 6:31 They found fungal species in the brains of certain Alzheimer's patients. 6:35 Just like parasitic infections like Top so have been associated 6:38 with cognitive issues. 6:39 But it's not only infections. 6:41 They've also found that things like environmental toxins like 6:44 pesticides, can cause amyloid production in the brain. 6:48 So all 16 factors 6:50 on the model have been associated with Alzheimer's. 6:53 And I published this in this case study. 6:55 So again this is one of the most important take homes from this case study. 7:00 And also the fact that for the first time we showed in this patient 7:04 that we could reverse this. 7:05 So the objective of this study was to determine whether DAPs on 7:09 combination therapy, a biofilm persist or antibiotic regimen 7:13 with good penetration into the central nervous system 7:16 can improve power levels and peripheral inflammatory 7:20 markers like rheumatoid factors, which our particular patient had, 7:24 whether we could reverse this in a patient with chronic Lyme disease TLDs. 7:29 And our patient happened to meet all the criteria 7:32 for chronic Lyme post-treatment Lyme disease syndrome. 7:35 She had the symptoms for about 15 years, she added M rash 7:39 she was Elisa positive x Elisa positive 7:42 very high in fact CDC positive IGN Western blot positive, 7:46 CDC positive IgG Western blood positive, CDC immuno blot positive. 7:51 So in other words, 7:52 every potential marker for post-treatment lung disease syndrome plus rash.
Patient case details and biomarker testing 7:57 This patient had she had had elevated 8:00 rheumatoid factors in her blood showing ongoing inflammation. 8:04 And she complained of joint pain. 8:06 And when we checked her Alzheimer's markers, 8:08 her Peter 217 marker was elevated at .33. 8:12 The reason this is important is because Peter 217 is showing up 8:17 is one of the most important factors that if you have this marker 8:20 15 to 20 years down the line, 8:22 the odds of having a demented illness is going to be much higher. 8:26 Right? 8:26 So she had this marker and she was complaining. 8:29 She actually she said, doc, 8:31 I don't even think I have major memory concentration problems. 8:34 I think my meditation is actually helping my memory concentration. 8:38 It wasn't until she actually did the nine week taps on combination therapy 8:42 that she said to me afterwards, oh, my memory concentration is much clearer now. 8:47 What I thought was happening with my meditation practice actually was not true. 8:51 The daptone actually improved my cognition, 8:54 and we also showed we reversed Peter levels into the normal range. 8:58 First time this has ever been proven right. 9:00 This is big news in the medical literature. 9:03 Even. 9:03 Again, if it's one case study, 9:05 we have to prove this in a multicenter, double blind, placebo randomized trial, 9:09 but still important, exciting information which I believe will be proven to be true 9:14 because all the prior studies we published on Dobson, 9:17 the number one statistical evidence, 9:20 the number one factor that that on help was always cognition. 9:23 It always showed up at around 70% of the patients approved the cognition. 9:27 But now we have proof 9:29 that we're actually starting to reverse some of these markers. 9:32 So in this particular patient and this was a 60 year 9:35 old female who had a history of chronic blind LDS. 9:38 She also had evidence of early Kiya but B0. 9:42 But BCA titers were elevated at 1 to 164 bit BCA micro T. 9:46 She had evidence of two Bartonella species, Bartonella quintana 9:50 and Bartonella hensley. 9:51 Her titers were elevated, although fortunately 9:53 she did not have evidence of active Bartonella 9:55 when she took the protocol, otherwise it would not have been as effective, 9:59 and she also had evidence of Cox yellow 10:02 fever, which again, the 10:03 titers went down over time and these titers were there 10:06 despite treatment with Doxycycline and Mallon 15 years prior. 10:11 So we looked at her rheumatoid factors before and after 10:15 they basically reversed from 33 to, down into the normal range. 10:19 And her Peto level, which was elevated at 0.33 10:23 normal ranges, less than 0.15 came down to 0.12. 10:27 Three months after finishing Dobson Combination Therapy, 10:30 where she said to us my joint pain is better. 10:33 The rheumatoid factors reversed her memory and concentration was better, 10:37 and the p tau 2017 levels reversed now again, over time. 10:42 Really, to do this study properly, 10:43 we need to follow patients much longer term to see what the effects are. 10:47 But it's the first time anyone has ever proven
Treatment results and reversal of inflammatory markers 10:50 in the medical literature that we can reverse these types 10:52 of inflammatory markers that are associated with Alzheimer's, 10:56 in the literature. 10:57 Now, why is this important in general? 11:00 Well, we know that Lyme disease, Briley Bergdorf, right, 11:03 has now been found, according to a BMJ Global Health, 11:07 that 14.5% of the global population has now been found to be exposed to Lyme. 11:12 One out of seven people 11:14 we know, according to the CDC, that it's about 476,000 people, 11:19 but that the Medicare rates are seven times higher. 11:23 This comes directly 11:23 from the CDC that theoretically means there are millions of Medicare people. 11:28 And again, as I mentioned to you earlier, this would be the population. 11:31 They found that in prior studies, up to 42% of people 11:35 55 years old had a chance of going on to develop dementia. 11:39 This is ridiculously high numbers, and we know it's coming from infections 11:43 and from five mental toxins, but no one has really looked at it 11:47 from the perspective of how do we unleash the disease? 11:50 The root causes of where's the root causes coming from of dementia? 11:54 And what can we actually do about it? 11:56 So now we're proving for the first time that if Lyme is the number one factor. 12:00 Now this patient, by the way, also had heavy metals. 12:02 We reversed her heavy metal exposure. 12:05 She did a six hour urine DMZ challenge and we gave her kills 12:09 with the MSA and some EDTA years before. 12:12 But she still had some of these cognitive issues. 12:14 Again, it wasn't as clear to her until a few finished 12:17 apps on how much her brain had been affected. 12:20 But we did work on these type of neuro inflammatory markers, 12:23 and we did work on heavy metals as best we could, 12:27 but she still had these problems going forward. 12:29 So we know that the symptoms of chronic Lyme disease 12:32 TLDs overlaps other particular chronic fatigue. 12:37 Musculoskeletal illnesses like chronic fatigue syndrome, 12:40 fibromyalgia, long-covid, mold toxicity. 12:44 So again, my advice for people who'd been diagnosed with a chronic fatiguing 12:48 musculoskeletal neuropsychiatric illness, please make sure you're being checked 12:53 for really Bergdorf Frye, for Bartonella, for all of the viruses 12:56 we're talking about, but being checked for all the factors on the 16 point 13:00 M6 model, because in my new book, Ending Chronic Illness. 13:04 Right. You can see it here. 13:05 We just got it from the publisher from Simon and Schuster, 640 pages. 13:10 It's my most expensive work, and you can find more about it on ending 13:13 Chronic illness.com, and it's available for preorder at this point, 13:18 we discuss in there the ABCs of Chronic Disease Medicine, 13:23 and in one of the chapters, A is for A.D.D., ADHD, 13:28 autism, allergies and ALS, allergies and Asthma and Alzheimer's. 13:33 I discuss how the 16 point EMRs model applies to all these different diseases. 13:38 So again, this article that I'm publishing in the Journal of Alzheimer's 13:41 Disease Case Studies.
Broader implications for Lyme, dementia, and chronic illness 13:42 We go through this in much greater detail in my book and in Chronic Illness 13:46 of how to look at what was actually found in the medical literature. 13:50 And by the way, 13:51 this book has approximately 2000 scientific references backing it up. 13:55 We will have the references on my website. 13:57 Can get better backing this up, 13:59 but we know that patients with chronic Lyme disease PTSD 14:03 can have associated changes, because Judith McCloskey has shown 14:07 that some of these patients with Alzheimer's may go on and have 14:11 problems with amyloid production in the brain. 14:13 And again, this group showed that a beta amyloid P tau and biofilm was associated. 14:19 And again, this is autopsy studies. 14:22 But there had never been an in-vivo a live patient who took a oral 14:27 biofilm persistent drug regimen like that, some combination therapy. 14:31 And we're finally publishing that we can reverse this, at least in the short term. 14:35 Again, there's a lot more to do in this area, 14:38 but very exciting preliminary evidence. 14:40 So considering that Alzheimer's disease is presently affecting 6.9 14:44 million Americans or older and expected to grow to 13.8 million Americans, 14:50 and that now you can check these Alzheimer's markers in your brain 14:53 by doing these blood tests. Request to LabCorp. 14:56 I think it's extremely important that for the Lyme patients and also the Lyme 15:00 that's out there that are listening to this mini talk, you go to quest. 15:04 Quest is actually my preferred lab to do this. 15:07 Please check that. Peter 181. 15:09 I can give you actually the codes for those who are listening. 15:13 The code for Peter 181 is number 13690. 15:19 The code for Peter 217 15:22 is quest code number 13825. 15:25 The quest code for beta amyloid ratio is 42. 15:30 40 is number 11786. 15:33 The quest code for neuro filament light is 13979. 15:38 And if you have what seems like you may have genetic 15:40 predisposition by ApoE e, you can check your genetic markers. 15:44 And chance the quest code is number 12563. 15:48 So please consider checking these markers. 15:51 Speak to your doctor about this 15:53 and if you are a Lyme doctor out there, please check your patients 15:57 and whether you are using whatever therapies you are using, 16:00 whether it's own or not, we now need to be doing is standardizing the protocols, 16:06 because knowing that Borrelia burgdorferi is one of the potential causes. 16:11 And according to the studies that I have in this case report, 16:15 the level of getting Alzheimer's is 13 times more frequent. 16:18 If you have an infection with Borrelia burgdorferi, 16:20 approximately one out of four patients with Alzheimer's, it may be due to Lyme. 16:23 Again, we're going to need larger 16:25 studies to prove this, but that's what the preliminary science is showing. 16:28 We need to be checking everyone at this point. 16:31 And then whether you are doing alternative therapies, natural therapies, 16:35 antibiotic therapies or using persistent drug regimens 16:38 like that on combination therapy, I would suggest strongly 16:42 you check these markers before whatever therapeutics you're using, 16:46 check them months later and see if you're making a difference. 16:50 Because ultimately, what we need to be doing in medicine is getting to the root
Recommended Alzheimeru2019s blood tests and clinical next steps 16:54 causes, not just treating symptoms, not just calling this 16:58 Alzheimer's dementia and saying, here's your namenda, here's your acetal colonies. 17:02 Ace inhibitors with aricept or using lecanemab. 17:06 For me, it's not enough. 17:07 I want to know what are the factors underlying dementia, 17:11 because many times you may find that there was it called B12 deficiency. 17:15 The were heavy metals in mold causing your cognitive issues 17:18 which happens to many of our patients. 17:20 Lyme and Bartonella was playing a big role in cognition. 17:23 But now we need to see 17:25 in a much larger study, both in the eyelid stocks and other docs out there, 17:29 we need to see whether we can reverse these markers and then publish this. 17:33 And please, for those who are interested, please contact us at our website 17:38 and also at medical@hvac.com. 17:41 That is our email for our office. 17:43 So if you're a doctor interested in participating in a larger study, 17:46 and we will be including these type of Alzheimer's biomarkers 17:50 when we reapply for an NIH randomized, multicenter, 17:54 placebo controlled trial of combination therapy. 17:57 Because I think it's extremely important now to show that not only can we help 18:02 those who have a chronic, fatiguing musculoskeletal cardiopulmonary 18:06 neuropsychiatric illness, but we may be able to stop 18:11 some of the long term ramifications like dementia and 18:14 a certain percentage of this population using some combination therapy. 18:19 So for those, again, for those patients who are worried about some combination 18:23 therapy, about the side effects, please see the mini talk that I did 18:27 on high dose taps on combination therapy of how we reverse the side 18:31 effects of Hertz's anemia, rashes and hemoglobin Amia, 18:35 and also the mini talk that I did on using lower dose some combination 18:39 therapy to get used to using them so that you do not deny yourself. 18:44 One of the most effective oral protocols I have ever found 18:48 for treating chronic Lyme shields. 18:50 And again, for more information and for looking at the documentaries 18:54 and all of the studies that we published on Dobson, 18:58 please again, see our website can get better.com 19:00 I have all of these studies published under the consultation service. 19:04 And if you have a doctor, all of my studies, by the way, are published. 19:08 So you do not need to use the consultation model. 19:10 I am not looking for business here. 19:12 I'm telling you this simply because some doctors are not comfortable 19:16 using this. 19:17 All of my protocols are published in the medical literature 19:19 so your doctors can use this. 19:21 I have many doctors using the protocols effectively, 19:24 and you can look at the podcast 19:26 that I did with Doctor Lamar's and Doctor Charlie Bissell 19:29 the year before, and the great results that they are having. 19:32 So again, I wanted to just give you a mini talk on the use of DAP, 19:35 some combination therapy for reversing inflammation like rheumatoid
Call for larger studies and closing remarks 19:39 factors, and out 2017 in this case study 19:42 that we submitted to the Journal of Alzheimer's Disease Case Studies. 19:45 Very exciting that we may have a new use for DAP, some combination therapy, 19:50 because it turns out that Borelli Bergdorf Frye 19:53 has been associated with amyloid peto and biofilm. 19:56 And now we have preliminary evidence that not only can we get 20:00 you better with Lyme disease, but we may and I say may be able to prevent some long 20:05 term complications, especially when we're in the middle of an Alzheimer's epidemic, 20:10 just like we're in the middle of a chronic Lyme disease epidemic. 20:14 This requires a lot more studies, but very exciting. 20:17 I'm so happy to share with you this information on our Healing Lyme Summit. 20:21 So again, this is Doctor Richard Horowitz, the co-host for the Doctor Talk 20:25 Healing Lyme Summit 2021. 20:27 We're talking about the Neuroinflammation Brain Protection Summit. 20:31 Thank you for joining me. 20:32 I look forward to seeing you again on another one of our talks. 20:36 Bye bye.
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