Full Transcript Introduction and Dr. Jen Flegaru2019s Background 0:00 This is Dr. 0:00 Jen Flegar and she's a DO in Nashville and we're going to talk about peptides and other related subjects that she is interested in. 0:10 And she has a book that we are going feature. 0:12 So Dr Jen, do you have a little background that you want to give us? 0:17 Yeah, so board certified in emergency medicine and integrative medicine. 0:21 About a decade ago, I did a fellowship in integrate medicine, still practiced in the ER while opening up my integrator medicine practice. 0:32 And now we live in Nashville. 0:35 We moved from Ohio about nine months ago and I have a virtual practice And my interests are, you know, niching down. 0:44 I came from just general integrative medicine practice because there wasn't anyone in Northwest Ohio providing that. 0:51 And now more hormone-based, specifically perimenopause and peptides and longevity. 0:57 So I love dealing with all of those. 1:01 Okay, great. 1:02 So I have a strong interest in learning more about peptides. 1:05 I've been to a few sort of introductory lectures about that, and I do carry one. 1:17 So my focus has been on the 7-step blueprint to optimal health. 1:22 And so my current fan base, I guess you could say, are familiar with that because I've been talking about that since 2018. So I want to share the screen 1:33 and show this document where peptides can fit into the seven-set blueprint. 1:40 Let me blow this up a little bit more. 1:42 This was given to me by an MD. 1:44 He also uses peptide. 1:46 And the first step of the seven steps is step one, which is diet. 1:50 And like you were mentioning, peptide prep. 1:53 So what does that mean in your office? 1:56 Yeah, peptide prep means you're not just gonna take someone, you know, off the internet and say, hey, let's do peptides and they're gonna eat the same, 2:06 they are gonna sleep the, same they gonna do all the things and you gonna just think that peptids are going to miraculously change all that. 2:13 I mean, that is what I'm seeing in the peptid world right now. 2:16 We have influencers recommending peptida, we have non-clinicians, non providers, none physicians recommending peptides. 2:24 And I think peptides should be for everyone, but I also think that they can be used, they could be mismanaged, especially now that their trendy. 2:33 So peptide prep is we're looking at sleep. 2:36 How can we optimize sleep before peptids? 2:38 We might bring in peptidized to optimize these things. 2:41 But first, we need to do the low hanging fruit. 2:44 and create habits, lifelong habits. 2:46 So we're going to look at sleep, we are going look nutrition, are we doing breath work, meditation, prayer? 2:52 Are we moving our bodies? 2:53 So first we need to do that because, for example, you're not going put someone on a growth hormone secretagogue and not have them work out or lift. 3:02 They're just going to gain weight because they're not going gain muscle. 3:05 So, I mean, there's certain things that we need to make sure and play, and I call that peptide prep.
What Peptides Are and How Theyu2019re Used 3:11 And my peptid course that I have on my website, which is very inexpensive, it's literally just to teach people what we to do when we look at peptides. 3:21 I've been prescribing peptids for almost a decade. 3:24 It's very important to Optimize when and how you use peptides because one of the downsides of peptide is they're expensive. 3:34 So we don't want to just use something expensive and not have it work as well. 3:40 I've felt like peptids work better when used appropriately and a lot of this takes working with patients. 3:48 It takes that just stault and it takes that knowledge and we're not seeing that. 3:54 I know you see Dr. 3:56 Schmidt like, have you seen these influencers for peptides now? 4:00 They're getting paid to like promote specific companies. 4:03 It's almost like a pyramid scheme. 4:07 Yeah, but so you're saying we can't use these out of context, right? 4:11 You have to have healthy lifestyle choices and habits, and then the peptides will work better. 4:17 We got to back up though. 4:18 I need a really good definition of peptide. 4:20 What is it? 4:21 Oh, yeah. 4:22 So peptids are chains of amino acids. 4:24 Amino acids are the building blocks of protein. 4:27 Now, proteins are usually a lot of amino acids together, and then that gets broken down and utilized in the body. 4:35 Now, peptides are shorter chains of amino acids. 4:37 They could be, you know, a couple amino acid. 4:41 We have a peptide KPV, which is just three amino-acids, or they could longer. 4:46 Usually, 36 aminoacides is the cutoff. 4:50 So these are used in a body to kind of like a lock and key. 4:57 have biological processes happen, you know, go into the body and help the buddy do these processes, like go in to the DNA. 5:10 And this is different from medication, which is like a crowbar, forcing things, okay? 5:16 GHK copper, for example, is a peptide. 5:19 It can turn on and off gene transcription. 5:23 And it's very fascinating. 5:25 So this is what peptides do. 5:27 There's also bioregulators, which could be another day we talk about that. 5:31 That is really short snippets of amino acids, tissue-specific two to four amino acid. 5:37 They're, there's like kidney bi oregulator, heart ones, thymus, pineal. 5:42 so that's, they're really small in their tissue specific. 5:46 Now, peptides can, and bioregulators are oral, so taken by mouth, mostly. 5:51 What does that mean, though? 5:52 Biore regulators of the heart, what's that means? 5:55 So it's tissue specific. 5:56 So, it going in there and it helping that tissue with these short snippets of amino acids. 6:02 And it is helping with biological reserve, is what Professor Cavison would say. 6:09 The Russians have used these for a while. 6:11 Those are our oral bi regulators. 6:13 Now peptides, which are a little bit longer, some of these chains, they can be given in different ways. 6:21 So they could be give an oral which we see a lot more oral peptide so capsules were taking it by mouth. 6:28 We see we've seen a long more in the last five years because of the FDA restrictions on injectable peptides and getting them from FDA-regulated compounding pharmacy, 6:41 which is safe. 6:42 You can get peptide. 6:46 It doesn't mean that it's real and it says it is similar to supplements. 6:51 I just have patients go through a compound pharmacy so we know you're injecting into your body what it actually is. 6:58 There isn't any contaminants either. 7:02 So injectable peptides are kind of the original way to get peptide. 7:09 They work better, they work really well. 7:14 versus the other modes like oral, still good, it's still utilizing it a lot and still works well, but some of them work better injectable, 7:23 like thymus and alpha one, for example, and VPC 157 for tendons and ligaments works better, injectible. 7:31 You can also give intranasal, you can give topical peptides. 7:35 I love GHK copper peptide, I loved that topically for the face, for hair. 7:41 So peptids are really cool and it's kind of like drinking out of a fire hose when you start to dive into them, but it gets easier and the letters and numbers 7:53 will start roll off your tongue, right? 7:57 So the most commonly referred to peptide would be the GLP-1 licozempic. 8:04 So, the way that I see that, it's a glucagon-like protein, right? 8:08 That's what GLPs stands for. 8:10 Glucagon is a hormone for digestion that's enhanced when you do a low-carb diet. 8:15 When you a high- carb diet, your insulin is very high, glucogon is low, then you'd do low carb and it switches. 8:21 That how I CLP1, these are This is a medical therapy to try to mimic a low carb diet. 8:29 Am I off on that? 8:30 Is that correct? 8:31 Yeah, or fasting or exercise can increase GLP-1. 8:34 There's a probiotic in the gut called anchormancia, and that can increased GLp1 production in a guy.
GLP-1s, Weight Loss, and Lifestyle Support 8:43 But you know what, like we have seen that semiglutide interzepatide, they are doing a little bit more. 8:50 They are modulating inflammation. 8:52 And they're doing other things where I think we've Hit a bad name for this was that too much at once and having it be a crutch because no one's changing 9:04 their diet and lifestyle and and this is because who came in who? 9:09 Came into the system the drug companies, so they're the highest dose You know who knows what else is in there? 9:16 Um, I, that's why I use compounded with my patients. 9:19 I know it's pure semi-glutide. 9:21 It's puriters, appetite, and we are having them on the lowest dose for the short amount of time. 9:26 And the patients that I'm using GLP ones with a lot of my. 9:31 Women patients, they're impairing menopause. 9:33 Maybe they have PCOS, insulin resistance. 9:36 They've tried fasting, eating well. 9:39 The peptide prep, we've balanced their gut, done everything. 9:43 We've even tried metformin, tried berberine, and they are stuck. 9:48 And that will just help them get over that bump, help with the food noise and have them, get habits situated, and get the habits incorporated into their life. 10:00 And then we get them off and wean them. 10:03 and they're not on super high doses because what we've seen with the GLP-1s is that patients' body composition was changing for the worse. 10:13 What I mean with that is they were losing muscle and not just fat. 10:17 And you can see these people walking around, they look like baggy, saggy. 10:24 They don't have muscle, and that we know muscle we need for longevity. 10:29 So it's very interesting that, you know, I mean, here's the honestly here is the hardest thing Dr. 10:34 Smith, like anyone could get a GLP one tomorrow delivered to their house if they want, but it doesn't mean they should. 10:41 And it does it they're not doing it correctly. 10:44 So my non negotiables, if someone's starting on a glp one, they have to be lifting weights, like in the weight room. 10:51 Lifting weights. 10:52 They have eat protein. 10:54 So 120 grams a day, try for 30 each meal, they to have be eating protein, which also means they shouldn't be on such a high dose of a GLP-1 that they're 11:04 so nauseous they can't eat at all, Which happens a lot if you go to a med spa or get the prescription, you can adjust the dose. 11:13 I'd like them to be on creatine, like a good creatines five grams a day and something called Pepti Strong, which is a peptide from the fava bean which 11:23 helps maintain muscle. 11:25 So they have to do these things to maintain muscles mass because I do not want them just to lose weight. 11:33 I want to change their body composition and fix the insulin resistance is the big thing. 11:39 That's a brilliant way you just said so. 11:42 But I'm assuming most doctors don't do all the things that you said. 11:45 They just put people on the drug and then good luck, right? 11:50 Yeah, you get the results. 11:51 You get results of weight loss, but a lot of it is muscle mass. 11:54 Yeah. 11:55 And it's out of control. 11:56 Yeah, or they get short-term weight loss and they're losing muscle and then they try to get off the shot and gain the weight all back because the food 12:07 noise comes back, because they haven't changed their body composition. 12:10 It's just very interesting. 12:12 The other thing that I've done recently with my perimenopausal women is that we might just do a low-dose GLP-1 just during the luteal phase. 12:22 So the Lutea phase is the second half of the cycle. 12:25 where your body is a little bit more insulin resistant, and you have those food cravings, which some women, you know, stress or whatnot, 12:36 they give into it. 12:37 They eat a lot of sugar, They binge on sugar. 12:39 So if they have a bit of GLP-1, we just cycle it those two weeks. 12:43 they they do so much better and this is what women are telling me they're like that is when I have my food noise if I'm just taking it then I do better 12:52 I can stay on my protein on diet and I don't know I just love it I love sinking Some of the supplements some of these peptides with a woman cycle because 13:05 they're not like men they don't have twenty four hours same hormone release it's different every day and that luteal phase. 13:14 You know we can look at papers we look out whatever people are saying on the internet but women when i'm working with women. 13:21 they do struggle sometimes with that part of their cycle and all of those studies everything goes out the window because it becomes an emotional response 13:31 you know food does and and they're busy so it's nice when we can use peptides to assist when they've been trying everything because I I know you've probably 13:43 seen this, like you might not believe that a woman standing in front of you who's overweight has tried everything. 13:51 You might think that they go home and they eat all day, but some of these women are at such a calorie deficit, they're so insulin resistant, 14:01 or I just had a patient that had mold toxicity, so was gaining weight while eating at a caloric deficit. 14:08 their body's just holding on to all this. 14:10 So, you know, sometimes we will use the GLP-1 peptides to get them over that bump and then they can start healing better. 14:19 But yeah, it's hard, and this is why we have to look at each patient separately, which is what you and I do versus the conveyor belt of conventional insurance-based medicine. 14:29 Right, so when you're saying use it to you get over the bump, how long? 14:35 Like they would be on that For a few months only yeah yeah sometimes a couple months I have patients on they stay on a low dose for a year. 14:46 Usually not much longer than that sometimes we pivot away from that and say hey like is there something like root cause that we need to adjust is this. 14:55 you know, do we need to try a different diet? 14:57 Do we to change things up? 14:59 A lot of the times it's with women. 15:01 It's just stress. 15:02 So we are going to balance out their parasympathetic, you get that activated more. 15:08 I mean, it is pivoting and then we could throw in other types of peptides too, to help if we think that they are gaining weight because they're just not 15:20 motivated to work out. 15:22 We can work on mitochondrial health with some mitochondria-derived peptides like MOTC or SS31. 15:29 we could increase muscle mass with a growth hormone secretagogue, Epimorlin CJC1295 as an example, take that five nights a week to help with muscle growth. 15:41 So there's different things to pivot from, but where I think the concern is, is that, you know, I was at a conference with a bunch of DOs and one of the 15:51 older DO's, his alarm went off for his blood glucose monitor. 15:54 And I'm like, Oh, hey, like how's that stuff going? 15:57 And he's like well, well I am on the highest dose of wagovi. 16:00 I've lost a lot of weight. 16:01 But then he was eating a donut for breakfast. 16:06 That's not gonna help. 16:08 So this is where this as a concern, because I mean, now, like, honestly, we're at the point where anyone can get everything and anyone could put anything 16:19 into an AI, you know, and be an expert, but it's Not wisdom. 16:24 It might be knowledge, But we are lacking wisdom right now. 16:27 I think when it comes to peptide. 16:30 Right, yeah, we're lacking wisdom in a lot of things. 16:32 There's so much data, single data points everywhere, right? 16:36 Like a trial and a study and survey and it's like we'll put it all together into a system that makes sense. 16:44 So having said that, If you don't mind, I'd like to go back to this list here. 16:49 Because in my system, it's primarily around cleaning, right? 16:55 Detoxing. 16:56 So it is almost like step one and two are preparing for cleaning. 17:01 And then the last step is cleaning the cells. 17:04 Then step O is optimization for enhancing nutrition. 17:08 But like, why would somebody take a, you know, vitamin pill if they got four foot tapeworms in their gut or if the have mercury and cadmium in themselves? 17:17 Yeah. 17:18 Yeah, so. 17:20 See, mentioned so energy mitochondrial enhancement for step two, he mentioned MOTC and then SS 31, right? 17:27 Mm hmm. 17:28 Yes. 17:29 So give us a little rundown on what those are. 17:31 Yeah, MOTC, I would start with that one, and then you could always follow up with SS31. 17:37 So they're mitochondrial-derived peptides. 17:41 And MotC activates AMPK, so it helps with metabolic flexibility, really good with fatty liver disease, it's really with metabolism. 17:51 This helps weight loss too, a metabolic support. 17:56 I love MOTC for actually kidney disease. 18:00 There's a lot of studies on this. 18:01 I think that this is something that should be given to anyone with any stage kidney problems because the kidney is one of the most mitochondrial dense organs. 18:13 So it's very helpful with that. 18:18 It also helps with mitochondria and stabilizing the mitochondrial membrane. 18:23 So that's also a mitochondrion-derived peptide that is used. 18:27 That also help with the fatigue and the energy. 18:32 It could be part of that step one of your process or are we on step two. 18:37 But those could definitely help because we're revving up the powerhouse of the cell and improving that.
Mitochondrial, Gut, and Immune Support Peptides 18:46 Okay, cool. 18:47 And then for drainage, oral bioregulator. 18:49 So when I say drainage I'm talking about kidney function, liver function and lymphatic system. 18:54 you know, sinuses. 18:55 I could see that. 18:56 Yeah, I mean, you could do some of the the oral bioregulators you can do. 19:02 Um, yeah, kidney, You could, do, um, stomach. 19:07 You can, to different ones. 19:09 And you, can you do pineal and thymus? 19:11 So the, so the world by regulars are kind of like glandulars. 19:14 That's is it? 19:15 Yeah. 19:16 Yes. 19:18 Yeah, so that could help for that. 19:21 Also, if you go back to that, because that is step is technically drainage. 19:28 Yeah. 19:30 So then step four for support. 19:33 Yes. 19:34 If you're doing more intestinal cleaning and you are going to be getting out like parasites and SIBO and Candida, is that what? 19:42 Yeah, yeah. 19:43 And ideally, I mean, ropeworms, but most of pudica seed is an herb that does a great job. 19:48 But I was hoping some kind of peptide for support and assist. 19:53 So you mentioned lorazetide and BPC-157. 19:56 Yeah. 19:57 Bpc- 157, you would take it orally for that support, and that would help the tight junctions in the gut and support inflammation in that gut. 20:09 is naturally occurring in the gut and very helpful. 20:12 So that would aid with that. 20:15 Also, lorazotide really is great for tight junctions. 20:20 If you have a lot of intestinal permeability, that is going to just seal it right up whenever I have like a stomach ache or I'm like, 20:29 oh, maybe I ate something off. 20:31 I always take a lorazetide. 20:32 Or if I thought I was like gluten bombed, I'd always travel with lorozetides. 20:36 So I mean, but lerozotide is also, it's actually looking to get into a drug. 20:42 It's in phase three trials through the FDA. 20:45 which hopefully it's still available for at reasonable price when that goes through. 20:51 But lorazetide, it is also good for kidney. 20:55 They're saying autism, Crohn's, all sorts of places, right? 20:58 Because it helps tight junctions of the cells. 21:00 So it makes the body do what it supposed to do and only have selective permeability versus Like everything is permeable because we're so inflamed. 21:12 So that one's great. 21:13 Also KPV is great, that's that tripeptide I spoke about. 21:19 so KPB, it's actually really good for inflammation and I'll use it with gut health also. 21:27 It's one that sometimes I will throw it in early on patients. 21:33 because it's really good for inflammation, especially like mold patients, almost like antihistamine kind of response. 21:44 So it really helpful for that. 21:47 It's a derivative from alpha melanocyte SH, which is low in those mold, patients especially in their NERS. 21:55 That one, I like that one. 21:56 I just think it calms down inflammation. 21:59 And it is very good like any acute inflammation even like joint inflammation, I've had it work well on patients because it's anti-inflammatory. 22:08 Nice. 22:09 Awesome. 22:11 Cool. 22:11 All right, so step five, that's cleaning the body of immune challenges from head to toe. 22:16 So parasites, virus, bacteria from had to tell. 22:19 Yeah. 22:19 Yes. 22:20 Thymus and alpha one definitely for supporting that. 22:23 That is derived from the thymis gland and as we age, we have thimus gland involution and it is a good part of our immune health, 22:34 and there's a thymus bioregulator, but thimus in alpha one is an injectable, which is great. 22:43 This is one that has been looked at during the pandemic. 22:47 It was being used in China for patients that were very sick in the hospital and it was working very well. 22:54 Then the FDA pulled it away from the compounding pharmacies and now we're able to get it at select ones again. 23:01 It's also something that I have patients that have cancer, I put them on thymus and alpha one so their immune system is more revved up and ready to fight 23:11 the cancer. 23:12 As we know cancer is a breakdown of our immune systems, basically, so that is really helpful. 23:20 Also, you can just cycle it. 23:22 I'll have patients use it if they have an autoimmune disease and use that along with the other gut health bioregulators or peptides that we spoke about, 23:33 the oral ones that will help. 23:35 So, yeah. 23:36 Thymus and Alpha-1 would definitely just be great for that systemic support for sure. 23:41 Yeah, let me throw this in. 23:42 So I have a variety of supplements that, like I've Thymex from Standard Process and Thymos PMG. 23:50 Those are the glandulars of the thymus gland. 23:54 And then here I put it, I typed in IPS, standing for intestinal permeability support for the step four next to the lorazetide. 24:02 There's supplements they have lamb intestine in them. 24:06 We have these glandular and the technology of that goes back to 19 teens and 20s. 24:12 But now we have the peptide, so I don't know if you know why... 24:20 So peptides being more expensive, probably more effective, faster, more powerful than the glandulars. 24:26 Do you have experience with glandular? 24:28 Do have a comparison between the two? 24:33 Some glandulars that I've seen with patients, like, you know, I like MP thyroid and stuff. 24:39 I think with some of the glangulars, maybe they're too big of proteins and not as specific enough. 24:45 And then more I have found with some glandulars for thyroid, they weren't consistent enough and they were very inconsistent and that caused my patients 24:57 problems when they would come to me on them. 24:59 So I'm more I think I just want it to be very, very specific. 25:05 So that's my experience with more glandulars versus the bioregulators. 25:12 They're just very cell specific, you know what you're getting, how they're going to work. 25:17 The thymusin alpha-1. 25:20 That's a peptide, not a glandular. 25:22 Right. 25:24 And then how large is that peptid? 25:26 How many amino acids is it? 25:29 Mm, not off the top of my head. 25:30 And so the purpose of that would be to rejuvenate the thymus gland. 25:34 Like, what does it do? 25:35 Yeah, it helps support the immune system. 25:40 So it's going to help. 25:41 It's gonna work like a thimic protein similar to the bioregulars. 25:45 There's also thiamid gin that is oral. 25:48 so it can help activate and support. 25:51 The immune systems again, because when we age, we lose that thimas. 25:56 Yeah. 25:57 You know, we lose that and things like obesity, things, like metabolic imbalance and that can also cause our thymus and immune health to decline. 26:11 And this is aging too. 26:14 You know our immune system and this is why we get you know diseases of aging and a lot of them are thymic related such as cancer. 26:23 Right and maybe so I've given people the thimex glandular and it's like their body goes through Like the flu, like they're sweating and they are killing 26:34 off organisms from head to toe. 26:36 So that's it's good that there's like it is parallel, right? 26:39 Parallel thinking. 26:41 Yeah, yeah, nice. 26:42 Okay, so step six, toxin binding. 26:46 You mentioned these three and then at the top says clearing senescent cells. 26:50 What's the senestent cell? 26:53 Yeah, senescent cells are like zombie cells in our body. 26:56 So if you think of a zombie, you know, they're dead, but they won't go away. 27:00 Then they just cause ruckus and inflammation there and aging. 27:08 off and get those away. 27:10 FOX04 can help with that. 27:14 That one's harder to get, I feel like, but that one could be used for that, and it's important to clear these senescent cells that can cause inflammation. 27:24 But really, when we look at clearing senesen cells, supplements work. 27:28 So there's senolytic supplements that could help that you use for five days of the month that supplements, the herbs, and that can help. 27:37 Also, fasting can clear out senescent cells. 27:42 We call this the fancy word autophagy. 27:44 Autophage basically means taking out the trash for cells and clearing those cells, but if we're eating 24-7, We don't get in that process of autophagy. 27:57 We're not supposed to be eating all the time. 28:01 Americans do, right? 28:02 So we never clear out those bad cells and take out that trash. 28:06 So then we have cellular debris and that's causing inflammation. 28:11 Think about if you left you know, garbage in your house for a couple of weeks and never took it out. 28:17 Like it's you're going to smell and see the effects of it. 28:21 Oh, yeah. 28:22 Yeah. 28:22 So so we're not taking out our cellular trash. 28:25 It's a problem. 28:26 You had mentioned supplements that you would take for five days to clear out these cells. 28:32 Well, like it would give me an example like what brand or what what's the name? 28:35 Yeah, there's one that I mean, I'm blanking on the one because I was using one. 28:39 Oh, qualula is one they have a pretty good synolytic. 28:45 I'm trying to think of the other one that I used for a while and you can type it in, you know, or I could give some of those later, 28:52 but quality law is a pretty good one. 28:55 They're bigger. 28:55 And then for females, I'd want you to take senolytics during the first half of your cycle, the follicular phase. 29:02 So I like to time even some supplements like senoletics with that, cause it's gonna, it sounds like a stress on the body, 29:09 But you are taking out cellular trash. 29:11 Though I liked to do that in the fullicular face for women. 29:15 Nice. 29:16 Okay, so we haven't, have we talked about Matzi yet? 29:19 Yeah, that was one of the groups, the mitochondria. 29:23 We named her one of our cats after Motzi. 29:26 Oh, did you? 29:27 Yeah, so she she because we found her in my office is stray. 29:31 So we have a cat named Motzy and then a Cat named Foxo for and Then a Kat named Mito, but for short for mitochondria.
Senolytics, LL-37, and Cellular Cleanup 29:39 I just like to mess with like, I don't know. 29:42 Like to name animals weird things. 29:43 Then it's a talking point like Oh want to hear about peptides anyway. 29:48 Yeah, I had a dentist who had white lab and he named that dog sugar. 29:52 Oh, no, that's true. 29:56 Yeah. 29:57 I mean, got to keep him in business. 30:00 Yes. 30:00 So then l thirty seven. 30:02 so tell us about that for cleaning out cleaning up the inside of the cells. 30:06 Yeah. 30:07 So LL37 is a really intense biofilm disruptor. 30:12 It can really disrupt mitochondrial membranes. 30:15 In fungus, viruses, it's actually interesting. 30:18 I was digging into studies because I'm sure you're the same. 30:23 What do we like to do? 30:24 We like read PubMed studies for fun. 30:26 But Ll37, I think I hypothesize in the next decade with some of these really resistant candida fungal infections, you know, 30:38 the super candita you read an article about every once in a while on the news. 30:43 Like I think LO37 would be the answer to that because it is such a strong biofilm disruptor. 30:48 This one, honestly, I don't use a lot. 30:51 We were talking earlier about like how many peptides do I use? 30:55 I'm like, well, probably like 20, but some them not a lots, like we keep them in our pocket. 31:00 So you can get these internasally. 31:02 I have a patient that has really bad like marcons in her nose. 31:07 We've tried a lot of different things and she feels a better after when using the LL-37 and after that it really cleared out a of that. 31:18 You can also inject this too but you really want to go low, start low and go slow with this and only use it, you know, for a short time, 31:29 like two weeks max. 31:30 I mean, this is just a very strong one. 31:33 And this also, I couldn't imagine using LL37, higher up on your protocol list because you'd feel miserable. 31:42 You would get a Hertz reaction. 31:45 You know, so this is something that is like a like if something's chronic, you would use LL 37 for you know hand in hand with your doctor and use it slow 31:56 because it is so strong. 31:57 Okay, interesting. 32:00 Yeah. 32:01 And, and I've had colleagues that have, you know, used it too fast, too early and like not good reactions to that. 32:08 So you definitely need to use it. 32:11 Just give this one, the respect, respect that it deserves, I would say. 32:16 And just do the other six steps before that so your body's prepared for it. 32:20 Okay, so here's step O, optimization. 32:22 So the idea of step 0 is to add in minerals and glandulars to support the body as they're going through detoxing and then when they are done cleaning the 32:32 some maintenance. 32:33 Does the term peptides fit with the terms maintenance or optimization? 32:38 Yes, optimization, longevity, fun, and fun stuff. 32:41 So you could do TB 500. This is basically thymus and beta 4, we like to call it, this is for like repair. 32:53 So you could do this with BPC 157 is like a Wolverine combo they call it. 32:59 Your patients are feeling good, they're optimized. 33:00 They're like, okay, I want to start lifting and I wanna lean down and just look so good. 33:05 And I'm gonna optimize. 33:06 You could put them on that. 33:07 you can put on a growth hormone secretagog such as epimoralin, semimoralin, CGC 1295. so you you do that five nights a week. 33:19 um, two day break, which, you know, talking about just everyone's a peptide expert right now, we were out to dinner with some friends and this guy really buff, 33:29 really gym rat. 33:30 And he's like, Oh yeah, I'm taking, You know. 33:32 I think it was taken in Sarah Moreland. 33:35 He's like, yeah, I take it just every night and or no, he didn't even take every day. 33:39 He took it in the morning. 33:40 I'm like Okay, first of all, you need to take the best time to it because it's a growth hormone secreted it helps your own body secrete its growth hormones. 33:49 It's not we're not giving growth Hormone. 33:51 You want to Take it at night on an empty stomach because that's going to mimic the natural pulse of growth. 33:57 Horman between 10 p.m. 33:58 And 12 a.M. 34:00 And five days a week and then off to because the receptors need to reset they need that break if you're just on the gas pedal that's not good. 34:08 So it's another thing about peptides is you do want to rotate them. 34:12 You don't want So those are great. 34:19 A fun one for optimizing like if you want to optimize sexual function would be PT 141. Love that as a nasal spray. 34:31 You can inject it. 34:32 It's actually FDA approved. 34:34 drug for female climatic disorder, but one of the side effects of injecting it is nausea. 34:42 So kind of defeats the purpose. 34:45 Um, so I, I get good results with patients using it intranasally, um, and add oxytocin in there, a little oxy tosin. 34:53 and male and females can use that like 30 minutes prior to intercourse. 34:58 So those are some fun ones. 35:02 Oh, five amino 1MQ, that is a peptide for mitochondrial health. 35:08 Also some lipolysis or fat burning properties. 35:12 That is an oral peptid that you can get compounded. 35:17 The five-amino 1 MQ is great. 35:21 I feel like I have some patients where they're like, I love it. 35:25 I want to be on it all the time. 35:26 It's great for me. 35:28 And then some people are like eh, didn't really notice a difference. 35:30 So, but yeah, have a lot of high performing patients that love five amino one MQ and do really well with that. 35:38 Nice. 35:40 That's a whirlwind of amazing data. 35:42 She's been working with peptides for 10 years. 35:45 Mm hmm. 35:46 Awesome. 35:47 Yeah, I really appreciate this. 35:48 So let's talk about peptide and hormones. 35:50 Is that the relationship there? 35:52 Like for female perimenopause? 35:55 Mm hmm. 35:56 Oh, yeah. 35:58 Yeah. 35:58 And when we when look at peptides with perimenopause, we want to support the individual and like what's happening to them. 36:07 So if they're having problems, you know, with their gut health first, obviously, find the root cause, make sure there's no toxins, 36:13 parent sites, infections, Candida mold, but we can support that with BPC-157 and KPV, lorazetide, there's lots of choices. 36:23 Women that are aging, their skin changes, you know, we're getting older, our skin is changing. 36:28 So GHK copper peptides are great for that. 36:32 GHk is the tripeptide and then copper, it has a high FNA for copper. 36:38 That's why it's going to look blue. 36:41 There's scalp GH K copper You can put it on your face. 36:45 There's cream for the body. 36:47 It's actually In the studies, they've shown that it increases follicle growth and actual the diameter of the hair follicles growing. 36:59 It helps with wrinkles, it helps skin damage, and it also helps wounds. 37:04 So I always carry a bottle of GHK copper with me if we're going on vacation, anything, because it help with wounds, sunburn, 37:13 aging. 37:15 My kids know what it is and they know to use it. 37:20 So muscle loss, I would say, you know, pepty strong. 37:23 It's an oral peptide that is from a plant peptides from the fava beans. 37:29 That's great for muscle growth and recovery. 37:33 Joint pain and inflammation, which comes with age. 37:36 BPC-157 injectable, KPV can help with that. 37:41 And then the growth hormone secretagogues that I spoke about, and then terzepotide and semiglutide, the GLP ones, that can helps in pairing menopausal
Optimization, Hormones, and Perimenopause 37:53 with hormones while we're getting hormones balanced, while our fixing diet and stress, which is rampant in midlife for women. 38:02 then we can layer in some of those to support them. 38:06 But yeah, so all of these are helpful just depending on what's going on with the individual patient. 38:13 I think that's key too to come up with these individual plans and rotating them and moving through midlife hormones and then into longevity is the goal. 38:25 want to talk about pricing. 38:27 So the injectables are more expensive than the oral, right? 38:31 But the injections are going to be more effective. 38:33 Give us some like ballpark figures for pricing on both oral and injectable. 38:38 And then the sprays to intranasal. 38:40 Yeah, yeah. 38:42 Um, Yeah. 38:42 It depends. 38:43 You want To go to an FDA know, a compounding pharmacy that has FDA approval. 38:53 Okay. 38:53 And make sure you're getting what you getting, because there there's actually been like some in Ohio, there was this med spa that got shut down because 39:02 they were getting semi-glutide from China, you know? 39:05 And then injecting it in there, like, oh, You have to come in once a week for your shot and charging hundreds of dollars. 39:13 who knows if it was even what they said it, was or if It had contaminants in it. 39:16 So it's very interesting. 39:18 But I would say for like the GLP ones, they're a little bit more expensive, like per month, it might be, you know, for four to $500, depending on the dose 39:26 you're on. 39:27 MOTC, yeah, four or $ 500 for six week course, but you only going to do that one to two times a year. 39:33 Intranasal PT 141, I think a couple hundred for that. 39:39 We say four two 500, first six weeks course meaning the whole six Yeah, not per shot. 39:47 Because that's the thing with my patients. 39:50 You get the vial, it's a multi-dose vile, you keep it in your fridge, your drawing it up yourself. 39:54 It's individualized for a lot of these and they have the control and the power, right? 40:00 They have to draw it off, they The oral peptides are going to be, you know, 100 to maybe 150 for 30 days worth. 40:11 So yes, less expensive. 40:14 You want to take those on an empty stomach. 40:17 And that's the thing, like you want make sure you're doing the other things. 40:22 Like if you are eating gluten, which opens up the tight junctions and activates the And then you're taking lorazotide for your gut inflammation, 40:32 which blocks insulin and tightens up the tight junctions. 40:36 That doesn't make sense. 40:38 Yes, you'll feel a little better, but why are you spending money on this? 40:43 So this is where it's not just a... 40:48 I'm gonna just take them and I'll be better for it. 40:53 Actually, you have to do work like everything in life. 40:56 I mean, not to say you can't take all the peptides you want and have a horrible lifestyle and eat however you like. 41:02 It's just not going to be as effective and they're expensive. 41:07 We want to respect that these things cost money and use them properly and get safe peptide too. 41:13 Yeah, nice. 41:14 All right, cool. 41:16 Anything else that you want to say regarding hormones? 41:21 Sure, yeah, hormones, perimenopause, just make sure you're working with someone that has proper training and is testing appropriately, 41:29 not just going by symptoms. 41:32 If you are getting a topical application of hormones you need to be testing saliva, and not serum. 41:37 So a lot of different tips and tricks when it comes to hormones because we still have to have knowledge and make that we are still getting the right care. 41:46 Because with the explosion as you have seen, of integrative and functional medicine, everyone is opening a wellness practice, 41:57 but they might not have the training and they may not experience. 42:01 So you can still get burned and I see it a lot. 42:05 That's why people are listening to your YouTube. 42:07 They want to be informed. 42:09 Grab a copy of the perimenopause reset and go through a whole lot in there. 42:15 about hormones and how to get hormones safely, how they navigate midlife too. 42:22 Yeah, what's your favorite lab test? 42:24 You said saliva, but what brand? 42:28 I'll use ZRT or doctor's data. 42:30 I guess Vibrant just came out with their saliva hormones, so I want to see them. 42:37 use a few different to just make sure you know keep it not one-sided but i usually use the rt and yeah yeah i've had women come to me regarding hormones 42:49 and i say i don't really deal with hormones i mean i'm fixing up organs and organs can be happier and work better and then hormones can balance but if 42:57 you want some kind of a you knows estrogen progesterone cream or whatever go see a a good doctor and um I just had I had a patient, 43:07 this is a couple years ago, she demanded that I run an extensive hormone panel so I picked a saliva one. 43:13 I didn't want to do it but we did it and I said look your symptoms are not from hormones just based on like my experience and what she was saying and sure 43:22 enough like everything came back pretty normal and she is very disappointed and i was like well you know like you got some other physiological things going 43:31 on so Yeah, but yeah, I appreciate that. 43:34 Yeah. 43:35 It's good you checked at least because a lot of women they are gaslit, you know, by their conventional doctors and at the start of perimenopause, 43:44 it's always the same. 43:45 They're always put on birth control and an antidepressant. 43:49 And they need neither of them. 43:51 Yeah. 43:53 What about the women's study back in, was it 20 years ago, and they stopped it early because it was causing strokes and cancer or something? 44:02 And the problem was the synthetic progesterone. 44:08 Yeah. 44:08 And so like, and now they're saying, oh, that was a mistake. 44:11 It was totally safe and we should start doing it again. 44:14 Yeah, um, the women's health initiative was awful. 44:17 So they were using estradiol, which is bioidentical, but they we're using progestins, pro-thrombus formation and effects on the heart. 44:30 Progestin, they are still prescribing them. 44:34 is not progesterone, which is bioidentical. 44:37 So that is, yeah, that was devastating for women's and women health. 44:42 And I will still see women overdosed on estradiol and some still getting it oral,which is crazy. 44:50 Now they're pushing the patch, if you look at the ingredients on an estrdiol patch it's all derived from petroleum, So all the patch ingredients that you're 45:02 putting on your body twice a week, you are literally applying endocrine disruptors versus a compounding pharmacy where you can get a cream, 45:10 which has coconut oil-based cream and non-petroleum-base, Versa-Base is very non toxic. 45:17 So, like I said, follow the money and see where all these patch Pushing, patch pushing, I like that actually. 45:27 All these, you know, they pick the curate female physicians for this agenda. 45:34 I'm very, very hesitant on this, but yeah, so this is what I am combating. 45:42 So wait, the problem was, 20 years ago I thought, well okay, The problem is progestin plus the estrogen, that estradiol, 45:49 and that was what was causing you know, major pathology, right? 45:53 Yeah. 45:54 But but why? 45:56 And is it was it true or was that false? 45:58 Because now people are saying, oh, that women's health initiative was a disaster and it's totally fine to do progestins. 46:04 And I don't know what they can. 46:06 Oh, no. 46:07 What are the problems? 46:09 Right. 46:09 So now but now, people were saying well, the women health initiatives, That was the problem because they didn't use projesterone or a bioidentical. 46:17 They used projestin. 46:18 That's a problem. 46:19 Right? 46:20 Yes, yes. 46:20 And but it's crazy still because it almost like you know when doctors said that smoking was healthy and they let you smoke in the doctor's office so it 46:32 was like these doctors like have to die off before we Oh, totally. 46:36 Yeah, yeah, science advances by funerals. 46:38 That's a quote from a long time ago. 46:41 Yes. 46:42 And I mean, we see we saw this with the pandemic and you know, this is just like a whole thing. 46:47 So because I still see women just if they don't have a uterus. 46:52 This is the thing, if you get a hysterectomy and they just put them on estradiol without progesterone, and that is not good either. 46:59 Our body needs pro testosterone. 47:00 It's balance. 47:01 We need it for breast health. 47:03 And that, that's another thing I'm still seeing is I'll have women come to me and they're like, well, I don't need progesterone because I didn't have a uterus. 47:10 So I need to protect that from, you know, endometrial cancer or pro testosterone. 47:14 Like, what about your breasts? 47:16 So that that is another hurdle. 47:19 I always go low and slow with hormones. 47:24 Women are also being way overdosed on testosterone. 47:28 These testosterone pellets are like a big thing in med spas and that is very dangerous and unnecessary. 47:36 So we're just seeing a lot of craziness right now in the hormone world. 47:42 So there was a time when there's a multi-level marketing company pushing progesterone cream, and there is a woman, she was trying to get everybody to buy it, 47:49 including men. 47:51 Men need projesterones too. 47:52 I got my husband putting it on the inside of his elbows, right? 47:55 And then within a year or two, people are testing sky high, crazy high projesterones. 48:02 So yeah, that was long time ago. 48:04 Oh, I mean, that's the thing, like the internet will say whatever they want to sell something. 48:10 And yeah, it's very scary out there. 48:14 So you always have to look at like, what are they selling? 48:16 And why? 48:18 What are their credentials? 48:19 and are They honest about their credential? 48:22 So that is what people have To do when looking at peptides, hormones, everything, right? 48:28 You mentioned your book, where can people get your Yeah, they can go to Dr. 48:33 Jen book.com or healthy by Dr Jen, either of those. 48:39 And I'd like to hang out on Instagram mainly at integrative Dr mom, integrate of DR mom. 48:45 Okay, nice. 48:46 Very nice, thanks for being on Dr, Jen. 48:48 I appreciate it. 48:49 Thank you. 48:49 That was awesome. 48:51 Totally awesome, I loved it, did you like? 48:55 Yeah. 48:56 No, i love I love being interviewed.
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