Biohack Your Detox DNA

Brendan Moorehead

My pleasure. Thanks for having me.

Kashif Khan

So Brendan Moorehead has been diving deep into this topic, and I’ve been excited about this conversation in terms of toxins in our food supply. So thank you for bringing this forward to us because every single person needs to know this, right?

Brendan Moorehead

Yeah, agreed. So I had the opportunity to interview Dr. Joseph Pizzorno a few years ago, and he’s been a naturopathic doctor for I believe over 40 years. He founded the Bastyr University up in Washington state. And in recent years he’s been saying like his main messages, as far as you can tell from reviewing the literature on many diseases, the primary cause of disease is mitochondrial function, dysfunction rather, caused by toxicity, toxins from our environment and our food, but primarily from food and water. So which of course is our environment. But so food is a big part of it. And shockingly actually, organic food is not entirely exempt from exposure to some of these toxins. And there’s a couple–

Kashif Khan

And that was.

Brendan Moorehead

For that, that I can get into in a minute. Yeah, go ahead.

Kashif Khan

Yeah, no, it was surprising to see because it’s so prevalent that I mean, you really don’t know where to go anymore and what’s safe and what’s not safe. Like you openly say that even organic foods, there’s certain things you have to look out for.

Brendan Moorehead

Yeah, so the problem with, so I wanna say first organic is far better in general than food as far as exposure, but we have this small molecule called glyphosate. It’s very, very, very mobile. It’s in rain water and it’s 65 or 75% of rain water in the United States. So that’s getting to everything. It’s also in the water, in the you know, irrigation ditches. So it’s going from one farm to another. They also spray herbicides like glyphosate on the ditch channels to control weeds as if the weeds are really a problem there. And so that’s poisoning the irrigation water, and then you have the issue. This is gonna be perhaps an eye opener for some people, but organic farms can use manure from animal.

Kashif Khan

Right?

Brendan Moorehead

That manure does not be from organically raised animals. It can be conventionally raised animals. So everything that’s going in the mouth of those animals and coming out the other end is going onto organic farms. That includes a lot of conventionally raised grains. And those grains are drenched in you know, glyphosate and atrazine, which is another herbicide. And which damages complex is two, three, and one, two, three and five of the mitochondria. And the other thing about what goes on to conventional crops that ends up in conventional manure is drum roll please, sewage sludge. So sewage sludge is allowed to be, you know, applied as fertilizer to conventional props and it’s called bio solids. 

That’s kind of the euphemism for it. And the thing about bio solids is there’s a lot of heavy metals going into bio solids from, you know, just municipal water supplies, industrial, you know, basically everything gets flushed down the toilet and many things that come out, the tailpipe of industry goes into municipal water supplies and ends up in sewage sludge slash bio solids. And the EPA has come up with a concept that they call sludge magic. And that sludge magic is the idea, the magical thinking that the organic matter, poop, of the organic matter in sewage solids, bio solids binds irreversibly and immobilizes irreversibly, all the heavy metals that are there.

Kashif Khan

Oh, wow.

Brendan Moorehead

Right, so arsenic, lead, cadmium, mercury, I think maybe thallium. I’m not sure, but those are those top four. The arsenic, lead, cadmium and mercury are pretty high in sewage and bio solids. So that’s going in and contaminating the conventional soils. And by the way, conventional soils get a lot of cadmium as well, because they’re when I say conventional or conventional soils or conventionally grown food, I just mean, you know, mainstream, chemical, highly mechanized, industrialized agriculture. So the phosphate fertilizers that are mined, so the ore often contains a good deal of cadmium. So cadmium comes along for the ride to the non-organic, you know, the conventional farms in the world. And so you get a higher amount of cadmium in the soil and legumes in particular, soy preferentially absorb a lot cadmium.

Kashif Khan

Oh, man.

Brendan Moorehead

So women with osteoporosis actually have been found to have been eating, typically they have a lot of cadmium in their kidneys, 16 year half life in the kidneys for cadmium, and it damages the ability of the body to convert 25 OH vitamin D to 125 OH vitamin D, which is the calcitriol, calcitriol, however you pronounce it, version that is actually the, ultimately the active form that is used to manage calcium. So, women with osteoporosis very often tend to be high soy consumers, and that’s, so that’s the mechanism there. So back to sludge magic. That’s how the heavy metals via phosphate fertilizer and bio solids are getting into organic food via the gastrointestinal tract of conventionally raised cattle and manure.

Kashif Khan

That is so mind blowing.

Brendan Moorehead

And then, so then–

Kashif Khan

Yeah.

Brendan Moorehead

So then organic, non-GMO soy is gonna be potentially high in cadmium because that, you know, there’s gonna be some higher cadmium in organic soils that are using manure.

Kashif Khan

Honestly, my brain is a little fried right now because it’s turning into sludge, you know, because there’s so, when you think about it, how do you escape all that? You know, it’s like, so prolific.

Brendan Moorehead

Go to Mars. That’s the solution. Just throw this planet aside and go to Mars. They don’t have an atmosphere there or water, but you know, we’ll get by. So how you get around this? So are we going straight to bio hacking?

Kashif Khan

Why not Brendan? I’m everybody’s jaws probably already dropped and now it’s like, what do we do about this?

Brendan Moorehead

Yeah. Lemme get back to you on that.

Kashif Khan

Yeah.

Brendan Moorehead

So, you know, having metals is, you know, it’s actually quite a trick to get heavy metals out the body and you don’t just wanna attack it with DPS and MSA. And there’s, you know, there’s these chelation clinics that they’ll just attack with that. And it can really mess people up ’cause they may not ready for that. Some people can handle just fine, but a lot of it has to do with their, the relative efficiency of their detoxification enzymes, which of course a big company can help shed light on as far as like, which, you know, snips you have and which of the GST, the you know, based enzymes that conjugate glutathione in phase two liver detoxification?

Kashif Khan

Right.

Brendan Moorehead

And so those transferase enzymes. And, but if we’re gonna look at it at going after heavy metals, you have to go all the way back and say, how inflamed is the person. Because if the person’s really inflamed, they’re gonna be really sensitive and they may react to just about anything. If you’re mobilizing metals, they can react to even good NRF two promoters, you know, like some kind of cruciferous vegetable extract. They can get inflamed from that, ’cause it’s just moving things too fast. So you have to deal with your inflammation. So one of the things that’s actually kind of cutting edge, a lot of practitioners are starting to use. I don’t know if a lot is the right word, but the at least someones I’m following are starting to use peptides.

Kashif Khan

Right.

Brendan Moorehead

So BBC, KPV are two oral peptides. You can take oral, you don’t have to inject. And then there’s others, TB frag 17, and stuff that are anti-inflammatory and can help calm down the neuro immune activation that has been generated by Lyme disease or just dysbiosis, you know, if somebody has really bad, really imbalanced gut bacteria, and then they have intestinal inflammation, which is by the way, aided and embedded by glyphosate because glyphosate is an antimicrobial that disproportionately kills beneficial bacteria, more than dysbiotic bacteria like klebsiella and pneumoniae. Now that organism and others may be more prone to producing more beta glucuronidase, which undoes your livers handy work by deconjugating the toxins that have been conjugated by the glucuronidase step as a glutathione.

Anyway, the glucoronidation the UDT enzymes and those toxins tend to be the fat soluble toxins like mycotoxins. So if somebody has mold toxicity, which is pretty common, then that can be deconjugated in the gut and then reabsorbed. So glyphosate is doing that. It’s causing dysbiosis. And if it’s causing dysbiosis and if it’s causing intestinal permeability, which is which dysbiosis does by itself, but also glyphosate upregulates zonulin which is a signaling molecule that tells the tight junctions in the gut to open. And it’s done, you know, judiciously when the body is normally regulated. So just, you know, judiciously samples what’s in the gut, but if you have glyphosate, upregulating it a lot, they just stay open and stuff comes through, and there’s more lipopolysaccharide from you know, the exterior of gram negative bacteria. And that is very inflammatory to the liver. 

So then the livers inflamed, and then one of the things that happens in that is some of the membrane transporter proteins in the hepatocyte membranes where they’re transporting bile conjugated toxins, and phosphatidylcholine into the biliary canaliculi, which is like the you know, headwaters of the whole, you know, biliary tree that drains down into the gallbladder. Those membrane proteins under inflammatory conditions can retract inside the cell and then toxins are not getting out. So as phase two conjugates are backing up and then phase one inter activated intermediates are backing up, and that’s where like the cytochrome P 450 enzymes in phase one are typically oxidizing something and making it temporarily more toxic, but more reactive. So it can conjugate more easily in phase two. And then the, when phase one intermediates back up, that’s really damaging to the hepatocyte and eventually to save itself or to push it back in the bloodstream, because as we all know, dilution is the solution to pollution. Even the liver knows that, right?

Kashif Khan

Yeah.

Brendan Moorehead

No, but that’s what happens when there’s anxiety in the liver, when you’re in a crisis state, you’re just like, well just dilute it for now.

Kashif Khan

Yeah, yeah.

Brendan Moorehead

So anyway, so now this stuff’s in the bloodstream and guess what? Glyphosate makes things, makes the blood brain barrier also more permeable and a preferential preferentially helps aluminum and other certain other toxins get into the brain, but aluminum in particular, and cadmium get into the lip into the kidney cells. So basically glyphosate’s making things more permeable, making everything absorb more toxins, and it’s also indirectly causing and pretty directly, too, causing the liver to have this breakdown and function because one of the study from P 450 enzymes, don’t ask me the number right now. I don’t try to memorize these things. I just know they’re there and I can look ’em up, but it’s one that makes bile acids. So glyphosate directly impairs bile acid production. 

It’s also directly impeding certain cytochrome P 450 enzymes that are involved with among other things beginning the bio transformation process of estrogens and getting them out of the body ’cause the body won’t like estrogen is in cycles, especially in women because there’s a period when the body, the female body needs growth signals, estrogen is essentially a growth signal, and then it needs to come back down. So it’s just this pulsatile wave. So female body needs to get rid of estrogen in a timely manner. But when you have glyphosate in the picture, that’s not gonna happen. Or it’s gonna get, or the pathways are gonna get deranged and you have more of the estrogens getting converted to the more toxic metabolites, like the four and the 16.

Kashif Khan

Right,

Brendan Moorehead

So, and then COMT has to come in, catechol-O-methyltransferase to, and that’s the phase two part of handling those glucoronidation can be involved as well with estrogens, but the COMT part comes in. And then if you have a bad COMT enzyme, a slow COMT enzyme and or if you have methylation issues, which would affect the supply of adenosylmethionine, Sam E, which COMT uses to methylate these things, then you’ve got double, triple trouble.

Kashif Khan

Yeah. You know what’s incredible? Everyone has to appreciate what they were just given access to because I think everybody agrees that people are sicker now because of our food, right. And there’s a lot of people still arguing that maybe that’s not true. That environmental health is not a concern, but what we don’t hear, we hear the genetics of it that there’s certain detox pathways, glutathione, you know, glucuronidation, the methylation pathways, all these things that support or don’t support what we’re facing, what we don’t hear, what you just laid out the exact insults, like exactly what is happening step by step and the way you just laid it out, it’s undeniable. Like here’s exactly what’s happening. 

And here’s why it’s a problem, right. And that’s what everybody needed to hear I believe because there’s always a little bit of gray area in environmental health. Why does it make me sick? I think one of the areas where there’s still controversy, where there shouldn’t be. And I think because of the sort of incentives or needs to make sure that we don’t all know the truth is with, you know, early childhood development with children. And that’s where the word glyphosate really gets used the most, right, in terms of functional medicine, et cetera. So what have you seen in practice in terms of, you know, the current child growing up today? Is the child different, are outcomes different? Is there a giant change in what’s happening in, you know, sort of environmental health versus their outcomes?

Brendan Moorehead

Well, I’m probably not the best person to ask that in terms of my practice, because I have not been working with children, but I, you know, I do know that so for example, back to Dr. Pizzorno.

Kashif Khan

Sure.

Brendan Moorehead

You know, quoting from the research, anybody can pretty much look this up as well, but the organic phosphate pesticides, they’ve done research on children of mothers that had some, you know, everybody has some level of organic phosphate pesticides. The children born to mothers with the highest level, I think they were using quintiles. So the women with the highest in the highest quintile or phosphate pesticides in their body compared to the women in the lowest quintile of organophosphate pesticides, the difference between those two cohorts or those two groups was a seven point difference in IQ in the kids.

Kashif Khan

Wow.

Brendan Moorehead

Of those to mothers. So organic phosphate pesticide has a big impact on the children’s IQ. And seven points is a big difference. People that, I don’t know how they come up with this estimate, but estimate that that’s essentially equivalent of a kid working hard and getting straight A’s and a kid working hard and getting C’s. So the difference in the prospects in life for those two children vastly different. It’s beyond tragic, and there’s… and there’s also been a study also, you know, I obviously I get all of my examples from Dr. Pizzorno, just kidding. I’m on a tear with him right now. So there was research done in, I think Seattle Washington, where they had children that were eating non-organic and they put them, they were eating like 75% conventional, I think it was. And they went to 75% organic or something like that. Or maybe it was a hundred, I’m not sure maybe it was 90, but anyway, they made a big shift from conventional toward organic and in 30 days, there the quantity of pesticide in their body dramatically plummeted. 

So, you know, assuming we’re dealing with kids that have reasonably good genes and stuff, ’cause obviously there are some kids that are pathological detoxifiers, kids with autism that have messed up detoxification. So that kind of rapid shift may or may not occur. We may not have it as fast in autistic kids, but that, but there’s actually a, like a documentary called secret, I think “Secret Ingredients” that Jeffrey M. Smith created of the Institute for Responsible Technology. So in that movie, they focus on one family and they had an autistic child and the mother and father also had some health issues and just by going organic, their health issues resolved. They must, they probably did a few other things that I’m not recalling, but that was one of the main things that they credited for their son becoming. I think he was basically no longer diagnosable as autistic by the time he was like 11 or something. And it, you know, it’d been about a five year period. So it was a delightful result.

Kashif Khan

That’s incredible. And this is a coming from a place where the belief is, it’s not reversible. It’s something that you have, right?

Brendan Moorehead

Right.

Kashif Khan

It’s a condition versus your body reacting to poor choices and poor choices are not necessarily the fault of the parent if you’re doing what everybody else is doing, but your child may not be wired for those things, right?

Brendan Moorehead

I would say we have to be really sensitive on the topic of autism because first of all, I don’t want to be interpreted to say that all you have to do is go organic and it’s that simple.

Kashif Khan

Right.

Brendan Moorehead

It’s not that simple most of the time. And it’s also not just a matter of, I would say of just of choices. Although if it’s diet then yeah, that’s choices, but there’s other, there’s typically other factors involved with autism and the genetic analysis is super important, but they’re also discovering that, you know, there’s, depending on who you listen to, like, you know, this group of autistic children, my God, 80 plus percent or whatever had Lyme pathogens, and then this other study is like, oh my God, the glyphosate levels were astronomical. Or, oh my God, all of these kids, they went autistic within three weeks of this particular vaccination, just all these factors that seem to have, but so it’s kind of like any disease can be caused. Almost any disease can be caused by almost any toxic insult to the body that dysregulates the body. So it’s not as one cause of autism. But if there’s one, the one that correlates the highest is glyphosate.

Kashif Khan

Right.

Brendan Moorehead

It’s crazy. It’s the, it’s as close to a correlation coefficient of one, as you can get. I haven’t seen anything higher it’s 99.7 or something like that. If you look at the graph or when they, when glyphosate, you started to really escalate in the, I think it was mid eighties or mid eighties.

Kashif Khan

Right.

Brendan Moorehead

I think it was mid, it was either 86 or 96. And I don’t know why I can never remember that one, but you look at it. They both just start to take off right at that point, glyphosate and autism. And the thing about glyphosate is, and then the other thing about autism is they find a lot of aluminum in the brain and a lot of, but aluminum. So, you know, there’s, so there’s the hypothesis. Well, there’s a lot more aluminum in the next generation or the like of vaccines when they got rid of the mercury part, right? That’s another story. They didn’t really fully get rid of the mercury part, but it’s not on the label anymore. 

And so, and then they started using aluminum as the official adjuvant and glyphosate transports aluminum into the brain. Glyphosate transports all kinds of things into the brain because it makes the blood brain barrier leaky. That’s probably, if there’s, if glyphosate is like the main cause it’s because of that mechanism and then whatever else can get into the brain, including Lyme pathogens or whatever Lyme gets right into the brain with, or without glyphosate, but glyphosate will help get in there for sure.

Kashif Khan

Yeah, I think your point, people need to understand that everyone’s looking for that cure, that switch to turn on or off. And this is why it’s such a tricky subject and referred to as more of a spectrum than a condition because so many things cause it, and what we need to look at is not the things, but the genetic profile of that child who couldn’t cope with whatever happened to be the trigger. It just, if something came before that, if it, whether it was Lyme, mold, you know, glyphosate, whatever it was, the order came in is the order that you’re gonna discover that it affected them. So it’s really understanding your innate wiring capacity to deal with any toxic insult and then knowing what all the potential insults are, right. 

And there’s many of them, and this is why it’s hard to point your finger on a cause, called the cause is really the inability to deal with all of this stuff, all the things you’re talking about. So one thing I wanted to ask you about is you did something incredible. You hosted a summit called Eat for Earth, and a lot of people are still buzzing about that, blown away. And you talked about how our food system is endangered. The planet is endangered. People drew a lot from that summit and it really changed the way they think. Can we dive into some of the things that you uncovered there?

Brendan Moorehead

Yeah, sure. So in it much of what I said just now from quoting from Dr. Pizzorno was part of hit one of, well, two of it, I did two interviews with him, okay. So he’s in there and those were great interviews. First one’s a little bit grainy ’cause the webcam one is, laptop while I was traveling was an older one. I’m like, oh my God, this one’s so grainy. But the content was great. And you know, what really blew me away hands down was getting to meet and talk to Walter Jehne twice. Walter Jehne is a scientist from Australia, and he, so Australia has this Commonwealth Scientific and Industrial Research Organization. I think that’s what CSIRO stands for.

Kashif Khan

Okay.

Brendan Moorehead

So he was both a soil scientist and a climate scientist and a very, very intelligent guy. And, but he is able to make things really clear and simple. And in our conversation, we talked about how, when it comes to climate water dominates the… the equation as far as heat retention by the planet.

Kashif Khan

Okay.

Brendan Moorehead

Water vapor is a far more powerful greenhouse gas than carbon dioxide but the climate models were based on carbon dioxide because, you know, back in, they started doing that after Carter wanted there to be, you know, commissioned a task force, I guess to investigate. Anyway, so it start, they basically made the assumption well, hydrologic cycles are too complex and massive for us to model. So we’ll model carbon dioxide. We’ll assume that as carbon dioxide, carbon dioxide’s greenhouse effect is amplified. That’ll then cause more water vapor, which will then amplify that cycle. But then they have to keep adjusting the model because it doesn’t really work that well. So, but the real kicker is that the greenhouse effect is only a counselor. I think it was, he said 4% of climate dynamics and energy flux, heat flux. So the rest of it is what? It’s hydrological cycles. Not, now water vapor is a greenhouse gas, but water is acting also over here as in other ways. 

So you have the flux of energy up into the atmosphere via transpiration, which is the water that’s moving up through plants and getting transpired into the atmosphere. So that’s one way that water is moving. The heat is moving into the atmosphere it’s being carried by the water vapor. And yes, the water vapor behaves as a greenhouse gas. But how is that heat actually getting out away from the planet? Mainly via rain events that open up an aperture in the atmosphere of all the greenhouse gases. And I’m not sure if I’m explaining that part correctly, but during rain events, a bunch of heat escapes into the upper atmosphere out into space. So that’s, there’s like this flux of heat from the earth back out into the atmosphere. And it depends on healthy soils, healthy plants, healthy ecosystems, transpiring, water into the atmosphere. And then it depends on normal cycles of storms and so forth, opening those apertures in the atmosphere. So heat can get out from the lower atmosphere, into the upper atmosphere and back out into space. 

So that’s basically, and those hydrological cycles, he named about 10 of them. And I wish I could say I had memorized them at the, but I think I had them memorized a few years ago. And now I don’t recall any one, but I gave you the gist, but, and there are things that we’re doing that are impairing that process. One of which is we’re creating what he calls humid hazes, persistent humid hazes, and that’s occurring via the dust that we’re putting in the atmosphere by desertifying the planet. And also by burning things like forests and cane fields and grasslands. So we put a lot of particulate matter up there. And then diesel, you know, we burn a lot of diesel. So that puts a lot of particulates up there. And that is creating these abnormal types of clouds. We could call them the humid hazes that don’t rain. So then you have far fewer of these events, which in the tropics would happen like daily, right? If you’ve lived in the, if you ever spent some time in the tropics, especially during the wet season for that particular tropical area, it’s like every afternoon, it rains.

Kashif Khan

Yeah.

Brendan Moorehead

It cools down. So it heats up, it’s building, it’s getting humid storm, storm brews. You have that four o’clock rainstorm, cools off. That’s not happening as much anymore. So they’re having abnormal rain patterns like deficiency of rain in, you know, in tropical areas. And so that’s, that was like a big aha from Walter Jehne is realizing that how climate actually works is not what we’ve been told. And yes, there’s a heat problem. And yes, there’s a carbon dioxide problem. But actually, and this is coming from another one of the interviews. The carbon dioxide issue is less the greenhouse gas effect and more so the fact that the ocean absorbs a lot of this excess carbon dioxide, like the majority of it and it in water, it turns into carbonic acid. So the oceans are acidifying. And if that happens faster than the organisms can take the carbonate and put it into shells and you know, exoskeletons, which then to the bottom of the ocean, as they die. If it’s accumulating too fast, the carbonic acid, then the pH drops acidity increases. 

And at a certain point it’s dissolving their exoskeletons and their shells. So already we’re seeing that, for example, pteropods, p-t-e-r-o-p-o-d-s, pteropods. So there’s pteropods, they’re little tiny snails. They’re a plankton planktonic organism. They’re like snails. They’re the base of the food web and the like Arctic type areas and like subarctic, like Pacific Northwest. So all the, I think krill even. I’m not, no, I’m not sure that krill is kind of more of an equivalent organism. So small fish and then salmon are eating the small fish and then the seals are eating the salmon, the orcas are eating the seals and the salmon. So that ecosystem is at risk if the pteropods dissolve, you know, and their populations crash. Another one is the… the algae, not the algae, the what do they call them? I’m totally blanking out. I had, unfortunately I had horrible insomnia last night, getting up yesterday, and I’m a fast oxidizer. So my adrenaline just goes crazy when I’m hungry.

Kashif Khan

Yeah.

Brendan Moorehead

So anyway, these photosynthetic planktonic, photosynthesizers that build a, like a little shell and exoskeleton around them.

Kashif Khan

Okay.

Brendan Moorehead

And those old exoskeletons are at risk of dissolving. I think some of ’em already are, and we’ve seen in some oceans of the world, like a 40% phytoplankton, that’s what they call them. Phytoplankton, phyto, meaning they’re like plants and they photosynthesize plankton, meaning they’re, you know, planktonic things floating around in the ocean. So the phytoplankton 40% dropped. This was as of 2010. I have not seen anything reported since then. So I don’t know if everything’s like copacetic for the moment or if they don’t want to talk about it, because there are some scientists that are like, yeah, we’re all dead. It’s just, it’s all over except for the shouting. And we’ve gotten until 2040 or 2050. I mean, that’s what some scientists have said, and I hope they’re wrong. And, but, and I tried to interview one of ’em. They wouldn’t like, there’s a couple scientists. They just didn’t wanna talk to me. And I figured because they probably just don’t wanna ruin everybody’s day, ’cause they’re gonna say something really negative, you know? 

But hopefully that’s not the reason they didn’t say yes to the interview, but it might be very dire. So that was one of the things we talked about in the conference. But the other thing is, okay, so you’ve got these really horrible stories that, oh, shit, things are happening that are really bad. And we didn’t know about them. We didn’t know about the phytoplankton, the pteropods we, you know, et cetera. The other flip slide is this is back to Walter Jehne. We just have to regrow the, what he calls the soil, carbon sponge soil. Soil is carbon that we can draw down all kinds of carbon from the atmosphere. He says, we can, you know, if we did the right thing on one billion hectares, which is about a fourth of the total agricultural land, including pastures, and a lot of this could be done in pastures. This could be a lot harder to convert the thinking and the practices of farmers on arable land, but on it’s it’s probably easier to get pastoralists to do their grazing differently. And there are ways of grazing animals that are profoundly beneficial to soil compared to really bad grazing habits that just ruin the soil. 

So there’s a good way and a bad way to do everything. Cows are not the enemy. It’s management, bad management is the enemy. So bottom line is we can rebuild the soil, carbon sponge and the whole photo synthetic machine and the transpiration machine that, you know, these technologies let’s say natural, the planet had it all figured out whether God did it or you know, evolution, whatever, it all worked perfectly. And all we have to do is stop interfering and get the soils working better. ‘Cause then we’re actually gonna have a cooler surface on the planet and we’re gonna have a functioning heat flux back out into the atmosphere. And we can suck a lot of carbon dioxide back out of the atmosphere into the soils. I think what I was about to say is Walter Jehne says, yes, we can draw down 20 gigatons of carbon every year. That’s twice our net emissions–

Kashif Khan

Wow.

Brendan Moorehead

Carbon is the atmosphere. So this if we could just get everybody focused on this, we could fix everything in a decade.

Kashif Khan

Oh wow. And yet you’re not hearing about this anywhere.

Brendan Moorehead

No, and we have this stupid distraction. You know, one of the things I was gonna say is like, in terms of like to echo, you know what Pizzorno said about toxins being the main cause of disease. And I think in an alternative world, we kind of know that, but it’s like the rest of the mainstream’s like, no, it doesn’t matter what you eat. No, no, it just happens. You know, disease happens. We can’t do anything about it, but we’ll treat you. But anyway, so you know, the World Health Organization, which, you know, has kind of lost much of their credibility recently, but they did some good research. They’ve done lots of good research over the years. And one of the things they concluded quite a few years ago is that toxins are like one of the main causes of disease. But anyway, now we have this other WHO sponsored thing that’s really distracting that yeah, so I think a lot of attention’s been drained away from that, from the planet.

Kashif Khan

That’s mind blowing, you know, when you think about all we hear is beef is bad. Beef is a source of all of our problems.

Brendan Moorehead

Worst message possible. It’s really, it’s just greed because I don’t think it’s just stupidity. I think that… There’s sort of an unholy alliance between the tech elite because they, you know, and just in general investors, you know?

Kashif Khan

Yeah, yeah.

Brendan Moorehead

It’s the next frontier. Monsanto’s been working and others like it have been working on owning food.

Kashif Khan

Right.

Brendan Moorehead

The one thing they had not yet conquered, I mean, ’cause they conquered a lot of crops and a lot of other things. They hadn’t conquered animals.

Kashif Khan

Yeah.

Brendan Moorehead

Can we just turn, can we just make all of our meat in a factory using intellectual property that we own? Bingo, nice new industry. Nice new frontier. Awesome.

Kashif Khan

Yeah, no kidding.

Brendan Moorehead

Really good for investors. That’s what .

Kashif Khan

So, I mean, if somebody hears this term eat for earth, like you’re about sort of.

Brendan Moorehead

Oh, well. Well, I had a Lume Cube and it just didn’t have as much battery life as I–

Kashif Khan

Okay, no problem. So when we talk about eat for earth at an individual level, you know, every, anybody that’s listening to what just happened here, I’m sure is, you know, gonna be compelled to say, well, what can I do? So how do you start? How do I eat for, how do I do what I should be doing?

Brendan Moorehead

Yeah, just go on a really long fast. So, well, first of all, the first step is well, you could go organic. So that’s like a baby step. For some people that might be a big step, but next step or a parallel step would be, get to know your farmer. They don’t have to be organic if they’re still, if they’re doing organic things, they don’t have to be certified organic. So if farmer’s markets, you can try to, you know, gauge whether you trust what somebody’s telling you and talk to them about how they grow things. And a lot of people say, yeah, you know, we don’t use this. We don’t use that. We use a little bit of this. We’re learning about regenerative agriculture. We’re not certified organic yet. We might do that. We’re, it’s, you know, it’s a lot of money to get certification, whatever. So you can get some, you know, feel that out. 

Now, there are some labels, some certifications that have been coming out the last few years that pertain to quote unquote regenerative agriculture. So what is that? So there’s, and there’s differences of opinion there. And unfortunately there’s this divide where the… I’ll just say the vegan and veganic movement that is very against using animals is very, and I think they have a point in being kind of concerned that regenerative agriculture tends to always claim that animals need to be part of the process. I think that animals are an important part of the process when it’s appropriate. And you can, there’s a whole conversation there, but I also don’t think that we should say that veganic agriculture is not regenerative because animals aren’t involved. I think we need to have a more key cohesive definition, a more inclusive definition of regenerative agriculture. 

That does not say that one of the pillars of organic agriculture is that you use animals and you use the manure, but it’s a great, as long as you’re not putting, you know, conventionally raised crops through those animals, bio solids, you know, heavy metals and stuff, then it’s great to use animals. And I won’t get, unless we really want to, I won’t get into like why animals are such amazing for so amazing for soil fertility. But organic agriculture generally has to do with, I mean regenerative agriculture generally has diversity. So you use diversity. You don’t do mono cropping. You have a lot of plants because that creates a lot of diversity in the soil organisms and you just get better, healthier soils. The other thing you do is you keep the ground covered at all times. And not or non regenerative agriculture, both conventional and organic, they’re constantly clearing the, all the crop off, all the crop, you know, waste, the stubble. And they’re just leaving this open soil to oxidize and put carbon dioxide in the atmosphere.

Kashif Khan

Right.

Brendan Moorehead

Kill the soil organisms. So whatever you gained in that growing season in soil life, you didn’t kill it with the sun and the you know, desiccation and corruption and whatever. So you gotta keep soil covered. And you it’s funny, I haven’t even looked at the four principles. They’re like four main principles. I haven’t looked at them in a while. So keep soil covered. You got diversity, typically include animal impact and so forth. And gosh, what else? There’s something else in there. So it’s embarrassing as heck. I haven’t even thought about the four principles, but again, like I’m totally sleep deprived and actually hungry once again, even though I just are few hours ago. So yeah, so regenerative agriculture look for, so there’s the regenerative organic certified, ROC label.

Kashif Khan

Okay.

Brendan Moorehead

Then it’s the, it’s ecological outcome verified, EOV. That comes from the Savory Institute as part of their, we call it land to… This is so… Yeah, I’m totally spaced because of this hunger.

Kashif Khan

Yeah, don’t worry. I don’t know the amount of output from your brain in the last little while. And most people would be asleep by now.

Brendan Moorehead

I hope I’m not putting other people to sleep.

Kashif Khan

No, no, no, what I mean is just, there’s so much you’ve laid out on the table. It’s like mind blowing, how you retain all of this, like the super computer that’s between your ears, you know?

Brendan Moorehead

I have to look this up, land to.

Kashif Khan

Yeah, let’s look it up.

Brendan Moorehead

Anyway, savory.

Kashif Khan

So while you’re looking it up, I mean question.

Brendan Moorehead

I can type and search and talk and think, sometimes anyway.

Kashif Khan

So I’m sure some people will notice that your headrest looks like it’s highly textured or maybe, you know, something going on there, but it’s, that’s your, it’s literally right behind you. Is that a mitochondrial light?

Brendan Moorehead

Oh, this?

Kashif Khan

Yeah.

Brendan Moorehead

And this is, by the way it’s Land to Market. That’s sort of the name of the program within which the EOV program resides. This is five different frequencies of red and infrared LED lights from Platinum LED’s.

Kashif Khan

Yeah, okay. ‘Cause I think it’s important to point that out because at the very beginning, what you said is that, you know, we are currently in a state where our poor mitochondrial function is causing all this disease, right? And a lot of that has to do with food. So we’re focused on fixing our food. So you’re just finished telling us some things we can do to eat better, but it’s so difficult to get things right. When it comes to food, especially with what’s being offered and who knows what it’s gonna look like in a few years with all the forces that you’re talking about that are trying to make changes, right. So there’s, you also have to work out the other half that assume that you’re not getting the best. And then what can you do to support the damage being caused? Like what you’re doing right behind you, right.

Brendan Moorehead

Yeah, so let’s get into more of that. So I was talking about, you know, how can you source better? How can you source your food better? So like, how do you get these things outta your body, the toxins that you’ve accumulated? And, you know, part of it is also, you know, the other, the other part of the equation with conventional food and also to a degree with organic food is that the mineral nutrient density is not what it was. So there’s a graph that was created by a guy named August Dunning, PhD, and it’s out there on the internet on slide share. If you Google his name and you look for Eco Organics, it’s the name of a company that he had where he, and he was telling the story of nutrient depletion. And he shows that from early in the 19th, early in the 20th century to, I think year 2000, it was basically in some minerals and 85% decline. But if you look at some of the reports, you can find on the internet, they just look at like seventies to nineties or fifties to seventies or whatever. 

The USDA doesn’t seem to make it easy to find the data that he found. ‘Cause if you look at that broad swath of time, you’ll see a dramatic drop. And it correlates with the increase in mechanization where they start chopping up the soil more, more intensely with tractors stuff. And then applying the first wave of fertilizers, and then the first wave of pesticides. All these things had damaging effects on the soil’s ability to deliver micronutrients. So why is that important? Because at the foundation, this is not the only factor in metabolism, but we are enzyme machines. And that is a term I’m borrowing from Dr. Pizzorno. And so enzymes often require a cofactor and often that cofactor is a mineral. So if we’re short on minerals and glyphosate chelates minerals, once it’s patented as a chelator, in particular really goes after manganese and iron and cobalt and molybdenum and you know, there’s actually a lot of minerals that goes after that just binds to them. So we need these minerals to run our detoxification enzymes.

In particular, selenium’s pretty important. Manganese, well, let’s see. Yeah, manganese for certain, antioxidant enzymes, and of course there’s B vitamins. That’s easier to get, you know, from food. It’s not as depleted in food, but so you wanna make sure that you have, that you test your minerals and your vitamins and your toxic burden to see where you’re at. I would say that’s like a first step is people should know where they’re at. And of course look at their genes because you have, you know, disadvantageous genetic variance, you may be where the enzyme’s a little bit inefficient. And sometimes that inefficiency is its inefficiency at binding to its cofactor. So maybe if you can supply for cofactor, but that depends on whether it’s a vitamin or a mineral. You don’t wanna oversupply it, certain things. You can, but you can kind of oversupply riboflavin safely, and that’s gonna help support MTHFR. That’s gonna support that’s, you know, the methylation of folate, support GSR, which is recycling glutathione ’cause that requires riboflavin. So there’s a lot of, there’s certain practitioners that have been for decades just giving people a ton of riboflavin. So like Frank Shallenberger in Carson City, Nevada, he’s big on just giving people a lot of riboflavin, a few other things he does of course, but that’s just like one thing I thought that’s really smart. 

‘Cause if you look at riboflavin, it’s just, it’s pervasive as far as what it’s used for. It’s so important to mitochondrial function, energy production, and that the you know, we used to get a lot from eating more beef liver and things like that. So our more modern diet is maybe a little bit lower in riboflavin than traditionally. So again, you know, test these things, see where your genes are at, check your inflammation if you’re, and you know Malik, if you’re a really sensitive person, you may want to use things like peptides. You want to do things like that to simmer things down. If especially if you just react to everything, ’cause like some people they’re gonna get great results from like broccoli seed extract and milk thistle and taking, you know, this product or that product that combines, let say milk thistle, and you know, diindolylmethane from which is a modification of indole-3-carbinol from cruciferous vegetables, you know that upregulates nerve two and helps to balance, you know, these things you can take in certain ratios to balance phase one and two detoxification pathways in the liver. 

And that’s another point is like, it’s good. It’d be a good idea to figure out before you embark on detoxification, are you currently a pathological detoxifier? Which means you, your phase one is more active than your phase two or more efficient let’s say. And so you have a, if you have a tendency for phase two to not be able to keep up with phase one, then you get an accumulation of these–

Kashif Khan

Right.

Brendan Moorehead

Activated intermediates, and that’s really dangerous. And so those people get worse when they try to detoxify. So it’s important to figure that out and then sort like, okay, I may have to actually take a few things to calm down phase two and other things to raise, excuse me. I met phase one to calm phase one down and upregulate phase two. When I had like full on chronic fatigue syndrome. I used to notice that on certain afternoons where I was just like, I felt so heavy and so dead. And like, I just like, I couldn’t do a fricking thing. If I ate grapefruit, I would suddenly go, I just instant improvement in my, and I could start the function again. And I did not know what that was about. 

I just somehow intuitively gravitated to try and grapefruit as something, you know, and it has naringenin or is it naringen or naringenin? Anyway, it’s a bioflavonoid thing. I think it’s classified as a flavonoid, and it down regulates some of this cytochrome P 450 enzymes or maybe just one key one, I’m not sure. And so that could potentially resolve a state of pathological detoxification and help to rebalance things just by chilling out or overactive cytochrome P 450. And it’s not necessarily over, it’s only overactive for the context because if phase two can’t keep up, then it’s overactive in that context.

Kashif Khan

Yeah, It’s really cool how you can really get personalized. And when you truly do things for what you need, it’s so effective because you’re dealing with the root as opposed to the pain point. What you talked about, you know, that phase one and phase two, you made me, you reminded me of something that we learned in our research which is in the glutathione pathway, the GSTM one gene it’s potential. There is potential to have a copy number variation. You may not even have the gene, right? And we learned something very odd, that people that had both copies that were, you know, supposedly doing well were directly correlated with having autoimmune conditions. And this seemed odd because we would think that these people do a good job but this is exactly what you’re saying. They’re hyper detoxers. Where is it going? Right, If there’s no exit, right, and that’s why we’re saying, if you’re gonna get into a detox regimen, you better make sure you’re pooping and peeing properly before you start.

Brendan Moorehead

Yeah, that’s the fun thing is open those drainage path, right?

Kashif Khan

Yeah, and so, yeah, so what you’re saying is right on, and people need to know that it’s, you gotta be functional, don’t go in blind and say that this pill or this YouTube video, and only solve one piece of the puzzle. And the beauty is that it’s not that complex. If you wanna put the pieces together, like you’ve been listening to Brendan for a little bit here and you’ve already been told much more than I’m sure you’ve heard previously. So it’s the puzzle pieces are there just need to make sure you’re doing it well and A to Z, not just one piece or one segment and then try to figure out why it didn’t work, right? So, you do still practice, right? You see patients?

Brendan Moorehead

Yeah, I don’t call ’em patients because I’m not doctor, but yeah.

Kashif Khan

So, what do you call ’em?

Brendan Moorehead

Actually, I call them members.

Kashif Khan

Members.

Brendan Moorehead

I have a program. So they’re a member in the program. I run it through a private membership association.

Kashif Khan

Okay, very cool. And so that’s awesome because that’s what it should be. You know, if you’re coming to your health, it should be an ongoing quarterback as opposed to someone calling you when they broke something, right, which is kind of what we deal with medical as is like, I can do whatever I want, and when something breaks you have to fix it. That’s your job. Meanwhile, I’ll do whatever I want. So in your work, do you deal with a lot of women?

Brendan Moorehead

Yeah, women actually.

Kashif Khan

Okay, so that’s, I wanted to dive into that because everything we talked about so far, right, and then add on top of that, I’m a woman, right? Meaning that all of the hormonal considerations, which for sure exist in men, but estrogen dominance and toxicity. You touched on the four and 16 hydroxy estrogen, right?

Brendan Moorehead

Yeah.

Kashif Khan

So is what I’m saying, even something to consider that the sort of the outcome is much worse for women? Are you seeing that it’s, there’s more nuances or more detailed work required?

Brendan Moorehead

Yeah, they do have that added complexity. And they are even, go ahead.

Kashif Khan

So all I was gonna ask was that, is it that existing call of female hormone conditions like fibromyalgia, endometriosis, PCOS, all this stuff is just being exaggerated in nature or is it just another layer of problem they have to deal with?

Brendan Moorehead

I’m not sure if I understand the question.

Kashif Khan

Meaning that I am not me, but a woman may be wired for fibromyalgia genetically and based on her habits and the current reality of now our exposures, is that same woman now suffering for a much more aggressive version of fibromyalgia, or is this environmental exposure just causing new problems that they wouldn’t have had if they weren’t in this environment or this food environment?

Brendan Moorehead

Well, I think it’s kind of both, if I’m understanding the question. So, I mean, ’cause all these things like fibromyalgia and so forth, did we have these things 50 years ago? Or–

Kashif Khan

Right.

Brendan Moorehead

You have to go back 70. Like, no, I don’t even think there was a diagnosis of fibromyalgia in the world, you know what I mean?

Kashif Khan

Right.

Brendan Moorehead

Maybe there was, but it was like really rare.

Kashif Khan

Yeah.

Brendan Moorehead

So what changed? You know, things have been changing gradually over the last a hundred years, and there’s been an escalation of things and there’s you know, the uptick in glyphosate usage, for example, major, major watershed point where just it’s just regulating so much stuff, and so… and the female cycle’s very sensitive to a lot of different things. And one of the whole classes or categories of toxic substances are xenoestrogens, meaning right, foreign estrogens. So a lot of these things, you know, like phthalates, BPA. Mercury a is a metalloestrogen. It has estrogenic effects. So as these toxins that are estrogenic accumulate, they’re just really whacking out female systems. Mycotoxins, so mold toxins are highly estrogenic, in particular certain ones. I think it’s zearalenone, I think is the one that’s highly estrogen. And so why are we having so much problem with mycotoxins? 

We’ve had mycotoxins for eternity, but according to Dr. Dietrich Klinghardt, I’m not sure if I think this was, he said he was putting research that he did with another doctor where they put, they exposed mold to EMFs, electromagnetic frequency. So they had some mold, they did not expose it to, and some mold that they did expose to that electromagnetic frequency and the excretion of mycotoxins went up like 600 fold or something. And the toxicity of the particular mycotoxins went up. Like there was some change in the molecules that made it more toxic. So we have an exponentially higher exposure to toxicity from molds, apparently from EMF. So that’s just in the last few decades that we’ve had this massive avalanche of EMF exposure. This keeps intensifying. And the explanation of that, the theory behind this is that these organisms perceive like, you know, they can feel these frequencies and they perceive it as attack and they just defend more. ‘Cause that’s what mycotoxins are about. They’re just defending their territory.

Kashif Khan

Right.

Brendan Moorehead

You know? The most famous mycotoxin the world is tetra, is the penicillin. So penicillin was, is a mold toxin that kills bacteria. ‘Cause the mold’s like, nope, this is my turf. Get out, you’re dead. It’s very effective against bacteria. And so they have a lot of things that are very effective at killing other organisms.

Kashif Khan

So when it, when something’s that complex, like you’re dealing with the hormone issue is the foundational starting point. Then there’s the other food, environmental exposures, EMF, all this stuff, where do you start? Do you start with the actual condition or do you believe that the condition is a sort of, you know, it’s a outcome of all of this and let’s start here or do you have to do a kind of in tandem?

Brendan Moorehead

Well, I like to get the whole picture in view. So I do a super detailed assessment of history. The person’s history, their family, you know, history as well. They’re just more in broad strokes for the family, you know, all their symptoms, symptom clusters, look at their old lab test to figure out what lab test might be next. But, and just get that whole picture and start to come up with hypotheses about what the causality is. But ultimately whatever’s going on, there is kind of a general hierarchy, a sequence to go through. So I mentioned that you want to quell neural inflammation. That’s kind of in general job number one. And if it’s present, because that’s just, it’s just making the person too sensitive to everything. They can’t, the body’s in this defensive posture, and even benign supplements can be, they can react to. 

And if they’re in a mold environment, like you have to look at, is there current exposure? That’s like another one of the job number ones is, is there current exposure? You gotta get them out of that. So a lot of people have mold exposure, and they don’t know it. And it’s not like you can necessarily always just smell it. Oh my house stinks. I know I’ve got mold. It’s not that easy. And then there’s a lot of resistance. People have a lot of resistance to even looking. They don’t wanna entertain that idea. Like, no, I could never move. Well, guess what? You might just die there then, or just really suffer for 20 years and then die. But the, so that’s another one. There’s a lot of there’s, you know, there’s a lot of focus on heavy metals, but that’s not necessarily the first thing to go after.

So you want to get this the major inflammatory influences and mycotoxin is way up there. And then as we mentioned, look at well, look at the genetic picture. So could there be vulnerabilities that are causing them to be more likely to get dysregulated into oxidative stress and inflammatory pathways as a result of having the mold exposure or other toxins, which could be heavy metals, like I said, but so there’s certain pathway. I won’t get go there right now, but keeping with the sequence, then you want to, if the person, then you wanna strengthen the foundations because the person’s energy needs to be adequate in order to detox and for the immune system to function normally. And, you know, start to combat the infection that maybe it’s not been able to defeat. Or sometimes the infection has been actually reasonably well controlled, but their nervous system and their neuro immunology is still hyperreactive to the vestiges, even just fragments. 

There’s this one guy, I think his name’s Bruce Patterson that I’ve have understood to be, to have found that in Lyme and in COVID, most like long haulers, the, it’s the monocytes, I think that are carrying around fragments of the organisms that they’ve destroyed, but they haven’t been able to get rid of it. So it’s still an antigenic stimulant. It’s causing the body to be reactive to this pathogen that’s basically maybe gone or at such a low level. And so you have, so that’s where back to the top where we’re like, hey, maybe use peptides to remodulate the immune system. Then you can start to go after residual toxicities and stuff, once things are calmed down. So then, so where was I with the strengthening the energy, and you wanna do that carefully? 

So you support adrenal function, maybe support thyroid function, support mitochondrial function, but don’t push it too hard because the thing is, these people are typically, if somebody’s really messed up, I’d say these people, but I’m thinking of the population of people with chronic complex illness where, you know, it’s chronic fatigue syndrome ish kind of thing, maybe Lyme, I’m not sure, maybe it’s mold, too. And the there’s this thing called the cell danger response, or it’s a, it’s more of a concept. We don’t know that it is the you know, I think, but it’s a really great, well founded idea. There’s a lot of evidence behind it that the body goes into certain stages of responding to a threat. One of them is it transforms mitochondrial function from energy producing to defensive mode. And if you push them, they’re just gonna do more of that, which is produce more reactive oxygen species.

Kashif Khan

Right.

Brendan Moorehead

They’re not gonna produce more energy. They’re just gonna produce more inflammation and oxidative stress. So you don’t wanna push the mitochondria. You can support them a bit with like antioxidants, certain ones like CoQ10 and lipoic acid and so forth, vitamin C, but don’t like throw a bunch of L carnitine and stuff like that. There’s a time for that, but it’s probably not in the, with somebody’s in cell danger response, which is also gonna manifest in things like what they call CIRS. What is that, chronic? I always use the abbreviation, but it’s Chronic Inflammatory Response Syndrome. So that’s a concept of Dr. Richard Shoemaker. Now, not everybody follows, you know, his model. Some people find fault with it, but it’s as far as like how he treats it, but it’s a good model for as far as like what’s happening, this chronic inflammatory response and there’s mass cell activation. So all of these kind of fit into the same pot. 

They’re just different ways of organizing how you look at it. The bottom line is you have to calm things down and then you have to support energy in a gentle way. So the person can begin to detox. And once things get settled down, then you can do some detox. And again, like you were saying, you’ve got to open the drainage pathways. So if you look at yourself at a funnel, you know, your poop is coming out at the bottom. And then somewhere up here, you’ve got the gallbladder, the liver and the gallbladder. You’ve gotta have that bile secretion working well. And so unfortunately, glyphosate and some heavy metals are impairing all that. And if you’re dysbiosis, that’s impairing it. So one of the, after you get probably the first step in improving drainage in, you know, getting the bowels moving is simply to go and try to correct dysbiosis if it’s there, because that’s just gonna keep dysregulating the liver with the lipopolysaccharides.

Kashif Khan

Right.

Brendan Moorehead

So you’ve gotta deal with it. So that’s why, you know, all they say, all disease begins in the gut and you start with the gut. That’s largely true, but there are some things that are even higher priority, like trying to calm down the neuro immune response. Some of this, you can do all at the same time, but addressing that dysbiosis so that the emunctories to use an old fashioned term, will work and keep moving things out through the gastrointestinal tract and liver. You don’t want to burden the kidneys too much, you know? And when there’s overflow from the liver, then the kidneys are getting damaged because they’re not, you know, they are a detoxification organ, but they’re not meant to be the primary one.

Kashif Khan

Right.

Brendan Moorehead

Heavy metals are extremely damaging to the liver like cadmium as we mentioned. So, and then once you get that stuff moving, it’s good to also get the lymphatic system moving. So learning some lymphatic self massage, and there’s some machines out there that help with lymphatic drainage. That can be useful, especially if there’s, if there’s a pathogen load because a lot of those pathogens may be hanging out in the lymphatic system. So as you’re killing them, you wanna make sure they’re getting out of the yeah. And moving quickly. So what happens is they get dumped back into the bloodstream from the lymphatics and then go to the liver. You can’t have a congested liver. You know, you have to have that working before you work on lymphatic drainage.

Once you get all that going, it sounds really complex, but you know, it’s just kind of one, two, three, you just, you just knock it off. Some people can get stuck on one for a while. And some people just move quickly through and you know, they can be like in, you know, zero to 60, you know, all the way, all the way in top gear in a week or two. So it just depends the individual. And then, so how do you get this stuff out? Well, there’s different things you can use. As I mentioned to balance phase one and two, and to upregulate, let’s say glutathione, you know, production and conjugation, by the way, on the topic of glutathione is really important. There’s too much emphasis on just supplying glutathione.

Kashif Khan

Right.

Brendan Moorehead

The thing is, if you can’t recycle it, oxidize glutathione is an oxidant and it combines with oxygen to produce superoxide. And that is one of the key drivers of inflammatory stress. There’s this whole cycle, this whole pathway where EMFs life save indirectly via NF kappa beta. I think certain heavy metals, et cetera. IL-6 and Interleukin six, which was stimulated by COVID among other things. And infectious, all these things are causing the body to go into an attack, defensive attack mode, where it takes NADPH oxidide, oxidase, NADPH oxidase. Easy for me to say, let’s call it NOX. So the NOX enzyme is taking NADPH, and oxygen is creating superoxide because it’s gonna use that to shoot things. It’s gonna go crazy, come out guns blazing shooting at, you know, perceived pathogens or pathogens. And so we have this upregulation of superoxide, which can be caused by something that’s not even a pathogen like EMF’s, right? 

So this is another dysregulatory influence of EMF’s, but so NADPH is getting routed from, instead of participating in regenerating and recycling glutathione, it’s now creating superoxide and then superoxide is supposed to be controlled by superoxide dismutase enzymes. So there’s another place to look at your genes. See if that’s an issue. Plus, look at your manganese. You need your manganese for superoxide dismutase to work. And then if it’s not. So what those super, what superoxide dismutase is supposed to do is turn superoxide into hydrogen peroxide. And then the peroxidase enzymes like glutathione peroxidase, like the thioredoxins and like catalase they can then take the hydrogen peroxide to water and oxygen. 

So that’s how things work for us to control the oxidative in the oxidation, the oxidants that we’re producing intentionally. The water is intentionally producing oxidants to go after an invader or perceived invader. And, but these things can get dysregulated. You can have deficiencies of the cofactors, like selenium, which is a cofactor for the peroxidases and copper and manganese, which is our cofactors for two versions of the catalase enzyme. And then you have, so here’s what happens. So if superoxide is getting produced in excess, it’s not getting shunted off into hydrogen peroxide. And then water and oxygen, then through a variety of steps, there’s a few steps. It goes and combines with nitric oxide. So you have superoxide superoxide combining with nitro oxide to produce peroxynitrite.

Kashif Khan

Right.

Brendan Moorehead

So that’s the peroxynitrite cycle. And that’s being implicated in more and more diseases. So it’s like a new frontier, like, oh my God, we see peroxynitrite upregulated in all of these conditions. So that’s another thing that’s being discovered. And it’s, and how did I get on that topic? I guess I was basically saying that that there’s all these things that can be happening that are keeping, distracting the body’s resources from detox.

Kashif Khan

Yeah.

Brendan Moorehead

Because now you’re using up the NADPH, there’s a guy that calls it the NADPH steal. Bob Miller calls it NADPH steal, ’cause it’s stealing the NADPH resources over to that war time use instead of peace time. Peace time use would be antiaging, you know, detoxification, water skiing, you know, whatever with your energy. So. And where was I?

Kashif Khan

Yeah, no, I mean, everything you’ve laid out, this is stuff where people wanted to know the actionable side of it, meaning that these are all bits and pieces that you hear right, in different conversations, but we don’t know what to do with it, right. And I, yeah, really honored that you gave us this time because you made it so clear, so concise. Right, and the you’ve condensed.

Brendan Moorehead

I don’t know about concise, but .

Kashif Khan

Well concise meaning in the way that, the number of things that you just laid out, you know, we could have just talked about one portion, like the you know, like you said COMT like just that. And, but you gave us the whole map. And if anyone replay this, listen to it three, four, five times ’cause you’ve been given the map, here’s exactly how, what you need to do and start working on it bit by bit by bit, start working out on the, or in the order you were told. So you don’t cause yourself a, you know, a plug up or clog up, you know, do it in the right, the right fashion. But this is it, Brendan. It’s it’s obviously we know that food is a concern. We know that from glyphosate to everything else, that’s being ingested, not only through our food, but through our skin and through what we breathe. 

There’s no doubt that chronic disease in general, it’s a part of life now where it used to be an anomaly, right? Like you said, fibromyalgia, wasn’t a thing 70 years ago. It’s now a given, you know, some kind of hormonal disruption and hormonal disease. So long story short is I want to thank you because this was mind blowing for me. And I hope everybody enjoyed it as much because you were able to really actionable, in an actual way I should say, deliver here’s exactly what you do. Right, here’s all of it. Here’s what you’ve been, your members have been benefiting from. And we just gotta sneak peek into. And I should ask you that maybe before we go, how do people work with you if they want to?

Brendan Moorehead

Well, good way to connect would be to actually download the free report.

Kashif Khan

Right.

Brendan Moorehead

So, and I think I’m changing the name from how to stop agricultural toxicants from killing you. Why eating organic cause not enough and how to biohack your DNA to protect yourself or something long like that to just, I think I’m simplifying it to biohack your detox.

Kashif Khan

Right.

Brendan Moorehead

So look for that. One of those, either the real long title or the short title and download that. So that’s gonna present what I’ve just discussed in more detail and in a more organized fashion. And it’s it’s each topic is done for each concisely, but there’s a lot of detail there. And then it comes into some pretty detailed steps people can take. And then, you know, also, so there’ll be links in that to, you know, where they can go to schedule a free–

Kashif Khan

Right.

Brendan Moorehead

Conversation. I actually have meant to embed my scheduling form on a particular. You know, they could go to bioindividualblueprint.com. On its own website right now, but it will be in a moment. So, and it does forward to a page that’s functional. So bioindividualblueprint.com. Also check out the Eat for Earth event. You’ll get on my newsletter there. Go.eatforearth.org if you wanna sign up for a free viewing period of those Eat for Earth interviews that we talked about.

Kashif Khan

Right?

Brendan Moorehead

And what else? Yeah, and I wanna say that, you know, I love the DNA Company’s concept of storyboarding, right. And because that’s essentially what I’ve been trying to do is there’s these different stories. There’s these cycles, each cycle is a story. It’s this thing that could be happening as a result of these various influences. And you kind of gotta map all these things, figure out you don’t necessarily have to map ’em all, but it’s a good idea to look at your genes and look at your symptoms and figure out, okay, it looks like maybe the peroxynitrite cycle is happening and there’s, you know, you could look at, you can look at certain tests where look, if there’s DNA damage evident in certain metabolites that show up in urine, and that would be potentially caused by peroxynitrite because it, and the carbonate radical, which comes off of that, which is off of that cycle, which are damaging to DNA. But yeah, so, and that’s, but generally I work with people in as both in one on one and in group context in a group program. And so those are some options we can talk about if you, if one of the listeners wants to.

Kashif Khan

Yeah, that’s amazing. We’re gonna share the link so people can download that guide that you produce. And I’ve signed up for the newsletter myself because I’m anxious to learn more. I suggest everybody does. It’s a blessing that you have access to information like this when we’re all struggling. The reason you’re here today is to figure out the why, like what’s going on. Well, here it is. You know, you, you have access to it. Thank you again, Brendan. This was incredible. It was, you know, all the answers that I personally was looking for, you sort of laid out and more. So thank you again for your time.

Brendan Moorehead

Oh, my pleasure. Thanks so much for having me.